Science 10
Unit 2-Biology
Science 10-Biology
Activity 8
Worksheet on the Nucleus and DNA
10
Name ___________________________________
Due Date ________________________________
Use pages 344-346 of your Science Probe text to help you answer questions 1-15.
1.
The “controller” of the cell is the __________________________________________.
2.
Catalysts to speed up chemical reactions in the cells are called ___________________.
3.
Does one enzyme speed up a number of different reactions or just one type? ________.
4.
The nucleus controls the cells activities by controlling the production of ____________.
5.
The function of the nuclear membrane is to ___________________________________
_____________________________________________________________________.
6.
Molecules of ___________ within the nucleus control the production of enzymes.
7.
Each chromosome in the nucleus is made up of ___________ and a variety of ______.
8.
Human cells normally contain ___________ chromosomes.
9.
A strand of DNA is a huge chain made up of smaller molecules called _______________.
10.
Each nucleotide in a DNA molecule has a base as part of it. The four types of bases found
on these nucleotides are shown by the letters ___, ___, ___, and ___.
11.
What is meant by a gene?
Worksheet on the Nucleus and DNA
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Science 10
Unit 2-Biology
12.
Look at Figure 15.20 on the top of page 346. On the left of this diagram, DNA is shown as
a ladder. The right and the left side of the ladder consists of long chains made up of “P”s
and “S”s. Each “P” stands for a ________________ and each “S” stands for a ________.
The bases are symbolized by the letters __, __, __ and __.
13.
The actual DNA structure is not really like a ladder, but like two coils wrapped around each
other. This structure is called a double ___________________. This structure was first
discovered by two scientists ____________________ and ______________________.
14.
The number and order (sequence) of bases on each gene determine the exact structure of
the ___________________ “coded” by that gene. Each chromosome contains thousands of
genes, each one controlling the structure of one protein or enzyme made by the cell.
15.
What do you think could happen if a gene coding for a specific protein has a “mistake” or
“incorrect arrangement of bases” in it? ________________________________________
_______________________________________________________________________.
Now go to a computer, go to my Science 10 Website (from http://sd67.bc.ca/teachers/barcuri/)
click “Science 10”, scroll down to “Unit 2 - Biology”, scroll down to DNA activity, on the right
will be the websites that you need for this worksheet. Click on the one called “Nucleotides(1)”
Scroll down a little until you get to the titles “The Pyrimidines & The Purines” at the top of
your screen.
Now look at Question 12 on this worksheet:
The bases are symbolized by the letters __, __, __ and __.
The diagrams on the web page show you the chemical structures and names for the four bases found
on DNA.
16. The Names of the four bases found in DNA are ________________________________,
________________________, _______________________ & _____________________.
(Do not include “Uracil” This is not in DNA)
17. Draw the structure of Adenine (A) in the box:
Adenine (A)
Worksheet on the Nucleus and DNA
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Science 10
Unit 2-Biology
Now, go back to the Science 10 Web page and click on the site called “Nucleotides(2)”
In the first sentence on that page, the words “phosphate group” are underlined. Click
on the words “phosphate group”
18. In the box below, draw a simple diagram of a phosphate group:
A phosphate
group
Next, click the “Back” button near the top left of the screen. This shows a diagram of a
“nucleotide”.
19. Each nucleotide consists of three parts:
i. A nitrogen _________ (one of four types)
ii. A sugar called ___________________
iii. A ____________________ group
Now, go back to the Science 10 Web page and click the site called “DNA Animation”
You will see the molecule called “2’-deoxyribose”
Put your pointer (will change to a hand) over the top left black atom (Carbon) on the
molecule on the left (5’). Notice a “C” atom is circled on the right diagram. This is one of
the Carbon atoms that can attach to a phosphate group. (It says that right below.)
Now, pull the pointer down to the “C” atom on the bottom left (3’). This is another “C”
atom that can attach to a phosphate group.
Next, scroll down a bit until you see a little green arrow near the left side. Click it.
Watch the animation to see how the phosphate groups can add on to the deoxyribose
molecule.
Now, click the little green arrow pointing to the right. It says “go on” when you hold the
mouse pointer over it.
20. Deoxyribose molecules and ______________________ groups join together to form long
chains (or strands). These long strands are sometimes called the backbone of the DNA
molecule.
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Science 10
Unit 2-Biology
Now, click the “Go on” green button again.
Watch the animation closely. You will see how the four bases (A,T,C &G) can
attach to the right side of the deoxyribose molecule.
21. As you move down the strand, any one of the four bases ___, ___, ___ or ___ will join onto
the right side of each deoxyribose molecule.
- Click the green button (Go on) again to see what happens. The picture you get is only
a very small part of a very long chain (backbone) with bases attached to it.
- Hold the mouse pointer over the word “Backbone” and the backbone is highlited.
- Hold the mouse pointer over the word “Bases” and the bases are highlited.
- Click the green (Go on) button again and it shows a longer view of the backbone with
the bases added to it.
- The order of the bases on the backbone is called the “Genetic Code”
- A long section of this strand with the bases in a certain order (code) will cause cells to
make a certain protein for the body.
- Each long section that “codes” for a certain protein is called a “Gene”.
DNA is not just a single strand, but two strands form and join each other with their bases in
the middle. This looks a bit like a step ladder. Next, click the green (Go on) arrow again:
22. When two strands of DNA join, the base adenine (A) will join ONLY to the base
______________________( ) and the base cytosine (C) will join ONLY to the base
______________________( ).
The little yellow lines between the bases from the left and the right sides are called
hydrogen bonds. Hold the pointer over the words “Backbone” and “Bases” to see each
one of them highlighted.
Now, due to the hydrogen bonds, the two strands don’t actually form a flat “stepladder”. They
coil around each other and form what is called a “double helix”.
- Press the green (Go on) arrow to see this double helix structure of DNA.
Watch this animation for awhile.
23. DNA consists of a long double ________________ with the ___________bone of each
strand forming the “coils” and the __________________ in the middle, joined by
_____________________ bonds. A base “A” can only join with a base ____. A base
”C” can only join with a base _____.
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Science 10
Unit 2-Biology
24. The human genome consists of __________________________________ base pairs on
___________ chromosomes.
25. The order of the bases in the DNA is called the genetic ____________ and this order of bases
in each gene (long section of DNA) directs the cell to form a certain ___________________
for the body.
26. In the following, rather complex looking diagram showing the structure of a small piece of
DNA, circle and clearly label one example of each of the following:
i.
ii.
iii.
iv.
v.
A phosphate group
A deoxyribose (sugar)
A base
A nucleotide
A hydrogen bond linking two nucleotides
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Science 10
Unit 2-Biology
Next, move to the following site on the Human Genome Project and answer the following
questions: http://www.ornl.gov/TechResources/Human_Genome/home.html
27.
Review question 11 on this worksheet to find out what is meant by a gene. About how many
genes are there in human DNA? ________________________________.
28.
How many base pairs (eg. A-G, A-T etc.) are there in human DNA? __________________
When did the Human Genome Project start? _____________. When was the project
completed? ________________________. How long will it take to analyze all of the data?
____________________________________________
Next, go to the following site and use the information to answer the following questions:
http://www.ornl.gov/hgmis/publicat/primer2001/7.html
30.
Give 5 ways that genome research can be applied in molecular medicine.
1.
2.
3.
4.
5.
31.
Give 5 ways that knowing the genomes of microbes (microbial genome research) can help us.
1.
2.
3.
4.
5.
32.
Give three ways in which DNA information may be used in fighting crime.
1.
2.
3.
33.
Give 5 ways in which genome research helps us or can help us in agriculture.
1.
2.
3.
4.
5.
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Science 10
Unit 2-Biology
Now, go to the site: http://www.ornl.gov/hgmis/publicat/primer2001/8.html
34.
Outline some of the concerns people have about genome research.
35.
What is your opinion about gene research? Should it be continued. What should and
shouldn’t be done with it?
Now go to the site:
http://learn.genetics.utah.edu/units/disorders/sloozeworm/
36. A mutation is a permanent change in the ______sequence of a ___________.
A mutation could cause some of the instructions to the cell to be ______________
37. What are the two ways in which DNA can become mutated?
1. _____________________________________________________________
2. ______________________________________________________________
Now go to the site:
http://www.kidshealth.org/teen/your_body/health_basics/genes_genetic_disorders.html Scroll down
until you get to “What are Genetic Disorders”
38.
About how many diseases are presently thought to be hereditary? ____________________.
Give four examples of genetic disorders:
1.
2.
3.
4.
39. What is the practice of “Gene Therapy” trying to achieve?
40. In what way will knowing a person’s genetic information help with lessening the chances of
getting these genetically related diseases? (Use point form.)
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