Learning Guide for Acute Renal Failure/Vascular/Trauma CMJ 2010 1. What are the functions of the kidney? Name at least 6: (p. 1136-1139) 2. The kidney regulates acid-base balance of HCO3 and ___(name the ion). (p. 1138) Explain why metabolic acidosis develops in renal failure. P. 1200, 1207 Why does Kussmaul breathing occur? P. 1200, 1207 What role do prostaglandins play in renal disease/hypertension? Why? P. 1139 What category of drugs inhibit prostaglandin synthesis (have antiinflammatory effect) and thus may effect renal function (even lead to renal failure)? (p. 1139 & 1203) Why are ACE Inhibitors sometimes contraindicated in renal failure? p. 1203, 1210. 3. Where is erythropoietin produced? p 1139 What effect does ARF have on erythropoietin production? p. 1200 Why would Epogen/Procrit sc be ordered? (p. 1210) *Note-use generally for CKD What lab values (include all) do you expect to be altered? p. 1200 4. Activated Vitamin D is necessary to absorb Calcium in GI tract. If a client has ARF, what usual changes are seen in the client’s serum calcium level? Why does this occur? P. 1200 6. (Review) Key features of these disease processes: Lewis pp. 1166-1169; 1176-1177 Disorder Due to/Manifestation/Treatment Acute Poststreptococcal Glomerulonephritis Goodpasture Syndrome Chronic Glomerulonephritis Nephrotic Syndrome Vascular Disorders of the Kidneys: What percentage of the cardiac output do the kidneys receive? ________ p 1137 RNSG 2432 1 7. What are several risk factors for renal vein thrombosis (occlusion)? P.1175 What are some common manifestations/complications of renal vein occlusion? 8. Renal artery stenosis: What is the most common manifestations/complication of renal artery stenosis? P. 1175 9. Renal trauma: p. 1175 Why is the H&H important when there is renal trauma? (p. 1175/Notes) Describe the usual management of renal trauma. 10. Renal surgery: Nephrectomy What should the urinary output be if client has a bilateral nephrectomy? pp. 1188 & 1227 Why is TCDB & use of incentive spirometry important post-op? (p. 1188) 11. Define acute renal failure. What is acute tubular necrosis? (p. 1198-1199) 12. Complete the table-compare/contrast the various causes ARF: p. 1148; Tab 471 Type Pre-renal Cause/Management of Acute Renal Failure Causes (name several) Key Features-Mgt Intra-renal Post-renal 13. What lab test most accurately reflects renal function and how are they determined? (Include both serum and urine based (p. 1146-1152; Notes) 14. What is the normal serum phosphorus level? level? (p. 1146-1152; 1200, Notes) What is the normal serum calcium Explain why these values are altered when a client has acute renal failure (applies also to CKD). (p. 1200, p. 1210) How are these alterations “managed” include diet, medications? (p. 1202-1204, Notes) a. What is usual amount of protein permitted? b. What about sodium and potassium? c. How are calcium and phosphate levels managed-include meds? P. 1210 RNSG 2432 2 15. Summarize in ARF/Laboratory Studies/Priority Actions (Lewis p. 1199-1201Notes) *Include BUN, serum creatinine clearance; “Fluid challenge Typical onset & duration Critical lab Priority management ARF Stages results Issues Initiating Phase Oliguric Phase Diuretic Phase Recovery Phase 16. How is fluid managed in acute renal failure once vascular volume and renal perfusion has been restored (after fluid challenge)- What formula is used to ensure that the client does not become fluid overloaded? (p. 1201 & 1203) 17. Why would a “fluid challenge” be used when a client is first discovered to have acute renal failure (may be anuric or oliguric)? (To discover this answer, read text, p. 1201 and Notes; note that the exact wording of “fluid challenge” is not used) Why would Dopamine may be given IV and what effect would it have on the on the kidneys? (Notes) 18. What is Kayexalate and when would this be used? Why is sodium bicarbonate used in ARF? What are indications for use of regular insulin and glucose IV: (Lewis p. 1202; Table 47.5) 19. Name some phosphate binders. When should phosphate binders be given and why? (p. 1210) What is risk of aluminum based phosphate binders? (p. 1210) 20. Why is a diet low in protein usually indicated for the client with renal failure? (p. 1202) 21. Identify medications/drugs that are known to be nephrotoxic. RNSG 2432 3