Action Medical Research and Tommy’s welcome new White Paper on preterm birth US nonprofit organisation, March of Dimes and the World Health Organization, release new White Paper on the global and regional toll of preterm birth Two of the UK’s leading children’s and baby charities, Action Medical Research and Tommy’s, both welcome the White Paper’s statement that strategies for reducing death and disability related to preterm birth must be given priority.1 Premature birth is a serious and costly problem and more research is needed to improve understanding of the causes of premature birth, and to develop strategies to reduce and prevent it. The White Paper released by the March of Dimes, using data from the World Health Organization, reports that in 2005, almost 1 in 10 (9.6%) (an estimated 13 million) babies worldwide, were born prematurely.1 Premature birth has an enormous global impact, emotionally, physically and financially on families and it is one of the major causes of death in babies under one month. Approximately one million deaths in the first month of life, 28% of total newborn deaths are due to premature birth.1 It can also lead to long-term complications like cerebral palsy, learning difficulties and hearing and sight problems. The White Paper showed that the highest rates of premature birth are found in Africa, 11.9%, followed by North America, 10.6%, Asia, 9.1%, Latin America and the Caribbean, 8.1%, and Oceania (Australia/New Zealand), 6.4%, with the lowest incidence in Europe, 6.2%. Although Europe has one of the lowest rates, individual rates vary between the countries in Europe. The incidence of premature birth in the UK is higher than the figure for Europe and is estimated at between 7-8%.2,3 [Draft TBC] Commenting, Professor Jane Norman, member of Action Medical Research’s Scientific Advisory Panel and Director of the Tommy’s Centre for Maternal and Fetal Health Research says: “More research is needed to improve understanding of the causes of premature birth, to identify women most at risk of premature birth and also to develop treatments to prevent it. “Additionally, the extent to which the costs associated with preterm birth are an economic burden has received little attention until now. Current research shows that the costs of 1 preterm birth extend well beyond childhood and into adult life. The White Paper findings emphasise the importance of preventing preterm birth and highlight the need for co-ordinated and global strategic approach towards research”. There are many risk factors for premature birth including nutrition and body weight, a previous history of premature birth, infection and the presence of medical conditions, for example, diabetes and high blood pressure.1 However, women with no obvious risk factors deliver as many as half of all premature babies, a further indication that more research is needed to tackle this problem. A recent Tommy’s funded study, published in Pediatrics Journal, showed that the annual total cost of preterm birth to the public over the first 18 years of life is £2.946 billion.4 According to Tommy’s calculations, this means that the total incremental cost of preterm birth to the public sector is estimated to be £939 million per year.5 . There is a challenge in collating data on the incidence of premature birth as few countries have good health statistics and information systems or birth surveillance registries. This is the first attempt to estimate the worldwide burden of premature birth and March of Dimes and the World Health Organization have agreed a two stage process, with the publication of the global and regional estimates, followed by a second document containing country level estimates that will be published in 2010. --Ends-- For further information please contact: Case studies of parents who have had premature births and, spokespeople are available for interview. Tola Awogbamiye at Action Medical Research Tel: 01403 327 493 Email: tola@action.org.uk Nina Diringer at Tommy’s Tel: 020 7398 3448 Email: ndiringer@tommys.org NOTES TO EDITORS: Action Medical Research Action Medical Research is a leading children’s charity. For nearly 60 years we have been instrumental in significant medical breakthroughs including the development of the UK polio vaccine and ultrasound scanning in pregnancy. Our research helps babies and children affected by disease and disability. One of our key aims is to fund research into serious conditions including premature birth, and other conditions that threaten unborn babies’ lives, 2 and find the best ways to care for those babies who need extra help at birth or in the first year of life. www.action.org.uk Tommy’s At Tommy’s we believe it is unacceptable that one in four women loses a baby every year. We want to give every baby the best chance of being born healthy, so we work to fund medical research into the causes of premature birth, stillbirth and miscarriage, and provide a free information service that educates all parents-to-be about health in pregnancy. Our information service is informed by our medical research and includes a telephone midwife service, a comprehensive website and free books and leaflets promoting health in pregnancy. www.tommys.org References 1 March of Dimes White of Paper on preterm birth: the global and regional toll; March of Dimes: New York 2009. NHS Maternity Statistics, England: 2006-07; referencing HES online, Maternity data, Gestation, Table 26 http://www.hesonline.nhs.uk/Ease/servlet/ContentServer?siteID=1937&categoryID=1053 3 NHS Maternity Statistics, England: 2007-08; referencing HES online, Maternity data, Gestation, Table 26 http://www.hesonline.nhs.uk/Ease/servlet/ContentServer?siteID=1937&categoryID=1053 4 Mangham LJ, Petrou S, Doyle LW, Draper ES, Marlow N. The cost of preterm birth throughout childhood in England and Wales. Pediatrics. 2009;123(2):e312-27. 5 How to calculate cost of premature birth: Incremental costs of pre-term birth (Average cost per preterm birth minus average cost per term birth), giving extra cost per preterm birth, multiplied by the number of preterm births. eg (£61391 – £41813) x 47982 = £939 million (See table 1.) 2 TABLE1 SCENARIO 1 - 2006 REALITY Number of live births Gestational Age Avg Cost Per Live Birth Incremental Cost Total Incremental Cost Total Cost 23 24 25 26 27 28 29 30 31 32 33 34 35 36 231 598 666 809 881 1,141 1,106 1,523 1,805 2,670 3,740 5,954 9,333 17,525 £19,760 £62,347 £72,645 £83,663 £94,904 £98,544 £95,364 £95,316 £88,981 £83,902 £67,179 £60,437 £52,086 £49,029 -£23,456 £19,131 £29,429 £40,447 £51,688 £55,328 £52,148 £52,100 £45,765 £40,686 £23,963 £17,221 £8,870 £5,813 -£5,418,320 £11,440,380 £19,599,761 £32,721,680 £45,537,190 £63,129,328 £57,675,765 £79,348,407 £82,605,951 £108,631,807 £89,621,882 £102,534,251 £82,784,364 £101,874,053 £4,564,560 £37,283,506 £48,381,570 £67,683,367 £83,610,424 £112,438,704 £105,472,584 £145,166,268 £160,610,705 £224,018,340 £251,249,460 £359,841,898 £486,118,638 £859,233,225 All Pre-term 47982 £61,391 £19,578 £939,401,883 £2,945,673,249 Term 621,618 £41,813 N/A N/A £25,991,713,434 All Births 669,600 £43,216 N/A N/A £28,937,386,683 3