Rodolfo Sacco, MD, Ph.D Gastroenterology Department, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy. r.sacco@ao-pisa.toscana.it Telephone: +39-50-997411 Fax: +39-50-997412 Subject: SUBMISSION OF A MANUSCRIPT FOR EVALUATION Dear Editor I am enclosing herewith a manuscript entitled “Likelihood of complete response for advanced liver cancer during sorafenib therapy: Case Report” for a possible evaluation and getting to the publication in “BMC Gastroenterology” With the submission of this manuscript I would like to undertake that the above mentioned manuscript has not been published elsewhere, accepted for publication elsewhere or under editorial review for publication elsewhere; and that my Institute’s Gastroenterology Department of Pisa University Hospital, representative is fully aware of this submission. Submitted manuscript is a Case Report We believe is worth of mentioning according to point 6 of instruction for the authors: “unusual case of an unexpected event in the course of observing or treatment a patients”. In fact to the best of our knowledge, it represents the first evidence of complete response to sorafenib in an elderly patient with advanced HCV-related hepatocellular carcinoma I wish you meet our manuscript interesting, please contact me if you need further clarifications/explanations. Regards, Rodolfo Sacco