James M. Williams, Ph.D. Curriculum Vitae Personal Information: Born: May 12, 1952 Pauls Valley, Oklahoma Family: Wife Children - Sammy Carol Williams married 12-31-73 James Tebe, born 9-22-78 Cecelia Jane, born 8-23-81 Samuel Michael, born 12-4-83 Present Address: Department of Anatomy Rush Medical College 600 S. Paulina St. 704 AAF Chicago, IL 60612 Telephone: 312-942-5501 Education: High School: Pauls Valley High School Pauls Valley, OK 1967-70 College: The University of Oklahoma Norman, OK B.S. (Zoology) 1970-75 Graduate: Department of Anatomy Indiana University School of Medicine Indianapolis, IN Ph.D. - 1980 Thesis advisor - Brian L. O'Connor, Ph.D. Thesis: Experimental Neuropathic Arthropathy: The Effects of Posterior Articular Nerve Transection on the Articular Cartilage and Subchondral Bone of Rat Knee Joints. Postdoctoral Research Fellowship: National Arthritis Foundation Department of Medicine Section of Rheumatology Indiana University School of Medicine Indianapolis, IN 1980-1984 Academic Appointments: 5/1/92 - present Associate Professor of Anatomy, Rush Medical College, Chicago, IL. 5/1/92 - present Associate Professor of Biochemistry, Rush Medical College, Chicago, IL. (conjoint) 5/1/92 - present Associate Professor of Internal Medicine, Section of Rheumatology, Rush Medical College, Chicago, IL. (conjoint) Awards and Honors: Fellows Award, American Rheumatism Association Central Region, 1982. National Arthritis Foundation Individual Postdoctoral Research Fellowship, Dept. of Medicine,Rheumatology Division, Indiana University School of Medicine. 7-1-81 to 6-30-84. Elected by the Rush Medical Class of 1987 to give the welcome address to the Rush Medical Classes of 1988, 1996, 1997. Scholl Foundation Rheumatology Fellowship, Illinois Arthritis Foundation, Rush Medical College, 1987-88. Scholl Foundation Rheumatology Fellowship, Illinois Arthritis Foundation, Rush Medical College, 1988-89. Travelling Research Fellow, Japan Rheumatism Association, 1993 Professional Societies: Christian Medical and Dental Society 1976 - present American Federation for Clinical Research 1982 - 1992 American Association of Anatomists 1983 - present Sigma Xi 1984 - present (Delegate to the National Meeting of Sigma Xi, 1984) Orthopaedic Research Society 1986 - present Osteoarthritis Research Society 1991 - present American Association of Clinical Anatomists 1995 - present Publications: Manuscripts: 1. Williams, J.M., D.L. Felten, R.G. Peterson and B.L. O'Connor. Effects of surgically induced instability on rat knee articular cartilage. J Anat 134:103-109, 1982. 2. Williams, J.M. and K.D. Brandt. Immobilization ameliorates chemically-induced articular cartilage damage. Arthritis Rheum 27:208-216, 1984. 3. Williams, J.M. and K.D. Brandt. Temporary immobilization facilitates repair of chemically induced articular cartilage injury. J Anat 138:435-446, 1984. 4. Williams, J.M. and K.D. Brandt. Exercise stimulates osteophytes and diminishes fibrillation after chemically induced articular cartilage injury. J Anat 139:599-611, 1984. 5. Williams, J.M. and K.D. Brandt. Benoxaprofen prevents osteophytes and fibrillation after articular cartilage injury. J Rheum 12:27-32, 1985. 6. Smith, G.N., Jr., J.M. Williams and K.D. Brandt. Interaction of proteoglycans with the pericellular (1 alpha,2 alpha,3 alpha) collagens of cartilage. J Biol Chem 260:10761-10767, 1985. 7. Williams, J.M. and K.D. Brandt. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically-induced articular cartilage damage. Arthritis Rheum 28:1267-1274,1985. 8. Smith, G.N., Jr., J.M. Williams and K.D. Brandt. Effect of polyanions on fibrillogenesis by type XI collagen. Coll Rel Res 7:17-25, 1987. 9. Williams, J.M., R.J. Katz, D. Childs, M.E. Lenz and E. J-M. A. Thonar. Keratan sulfate in the superficial and deep layers of osteophytic and non-fibrillated human articular cartilage in osteoarthritis. Calc Tiss Int 42:162-166, 1988. 10. Williams, J.M., C. Downey, E. J-M. A. Thonar. Increase in the level of serum keratan sulfate following the degradation of cartilage proteoglycans in the rabbit knee joint. Arthritis Rheum 31:557-560, 1988. 11. Williams, J.M. and E. J-M. A. Thonar. Early osteophyte formation after chemically-induced articular cartilage injury. Am J Sports Med 17:7-15, 1989. 12. Williams, J.M., K.G. Auerbach and A. Jacobi. Lateral epicondylitis in breastfeeding mothers. Clin Peds 28:42-43, 1989. (cited in the Yearbook of Pediatrics 1989) 13. Thonar, E. J-M. A., D.M. Manicourt, J.M. Williams, M.E. Lenz, M.B.E. Sweet, T.J. Schnitzer, L. Otten, T. Glant and K.E. Kuettner. Keratan sulfate as a marker for cartilage proteoglycan catabolism in osteoarthritis. J. Rheum. (suppl), 18:24-27, 1991. 14. Glant, T.T., K. Mikecz, R.R. Bartlett, F. Deak, E.J-M.A. Thonar, J.M. Williams, T Mattar, K.E. Kuettner and R Schleyerbach. Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide. Immunopharmacology 23:105-116, 1992. 15. Williams, J.M., J. Zurawski, K. Mikecz and T.T. Glant. Functional assessment of joint use in experimental inflammatory murine arthritis. J Orthop Res 11:172-180, 1993. 16. Williams, J.M., D.R. Ongchi and E.J-M. A. Thonar. Repair of articular cartilage injury following intra-articular chymopapain-induced matrix proteoglycan loss. J Orthop Res 11:705-716, 1993. 17. Homandberg G.A., R. Meyers and J.M. Williams. Intra-articular injection of fibronectin fragments causes severe depletion of cartilage proteoglycans in vivo. J Rheumatol 20:1378-1382, 1993. 18. Uebelhart, D., E.J-M.A. Thonar, D.W. Pietryla, D.R. Ongchi and J.M. Williams. Pyridinium crosslinks are increased in urine of rabbits injected intra-articularly with chymopapain. Osteoarthritis and Cartilage 1:185-192, 1993. 19. Kiester, D.P., J.M. Williams, G.B. Andersson, T.W. McNeill and E.J-M. A. Thonar. The dose related effect of intradiscal chymopapain on rabbit intervertebral discs. Spine 19:747-751, 1994. 20. Williams, J.M., M.E. Moran, E.J-M.A. Thonar and R.B. Salter. Stimulation of the repair of rabbit knee articular cartilage following matrix proteoglycan loss with continuous passive motion. Clin Orthop Rel Res 304:252-262, 1994. 21. Thonar, E.J-M.A., K.E. Kuettner and J.M. Williams. Markers of articular cartilage injury and healing. Sports Med Arthro Rev 2:13-28, 1994. 22. Ishiguro, N., D. Uebelhart, E.J-M.A. Thonar and J.M. Williams. Immunolocalization of atypical chondroitin sulfate chains reacting with the 3-B-3 monoclonal antibodies following chymopapain-induced injury in the rabbit. Osteoarthritis and Cartilage 2:285-288, 1994. 23. Xiao F, A Chong, P Foster, H Sankary, L McChesney, JM Williams, D Frieders and JW Williams. Effect of Leflunomide in Control of Acute rejection in Hamster-toRat Cardiac Xenografts. Transplant Proceedings 26:1263-65, 1994. 24. Plaza, V. L., E. J-M. A. Thonar and J.M. Williams. Experimentally-induced articular cartilage injury: The combined use of misoprostol and diclofenac as therapeutic agents.Amer J Therapeutics 3: 204-211, 1996. 25. Glant, T.T., J. J. Jacobs, K. Mikecz, J. Yao, S. Chubinskaya, J.M. Williams, R.L. Urban, A.S. Shanbhag, S-H. Lee and D.R. Sumner. Particulate-induced, prostaglandin- and cytokine-mediated bone resorption in an experimental system and in failed joint replacements. American Journal of Therapeutics 3:27-41, 1996. 26. Williams, J.M., Thonar, E.J-M.A., Uebelhart, D., Kocsis, K., Modis, L. The spatial orientation of the collagen network of articular cartilage is altered in rabbits following intra-articular chymopapain injection. Connective Tissue Research 34:105-117, 1996 27. Homandberg, G.A., Hui, F., Wen, C.., Kuettner, K.E., Williams, J.M.. Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: i. In vitro . Osteoarthritis and Cartilage 5:309-320, 1997. 28. Williams, J.M., Plaza, V.L., Hui, F., Wen, C., Kuettner, K.E.., Homandberg, G.A. Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: ii. In vivo. Osteoarthritis and Cartilage 4:235-240, 1997. 29. Rayan, V., Thonar, E.J-M.A. Thonar, Chen, L.M. Lenz, M.E. Williams, J.M. Regional Differences in the Rise in Blood Levels of Antigenic Keratan Sulfate and Hyaluronan after Chymopapain-induced Knee Joint Injury. (in press-J Rheumatology). Manuscripts: (submitted) 1. Chiba, K., Andersson G.B.J., Masuda, K., Momohara S., Williams, J.M., Thonar E.J-M.A. Thonar. A New Culture System to Study the Metabolism of the Intervertebral Disc. (submitted to Spine). 2. Kang, Y., Williams, J.M., Koepp, H., Kuettner, K.E., Homandberg, G.A. Hyaluronic Acid Suppresses Fibronectin Mediated Cartilage Chondrolysis to Human Cartilage in Explant Cultures. (submitted to Journal of Orthopaedic Research). Book Chapters: 1. Thonar, E. J-M. A., J.M. Williams, M.B.E. Sweet, B.A. Maldonado, M.E. Lenz, T.J. Schnitzer and K.E. Kuettner. Keratan sulfate as a marker for cartilage proteoglycan catabolism. In: Clinical Impact of Bone and Connective Tissue Markers. Lindh E. and Thorell, J. E. eds. Academic Press. New York, pp 229-234, 1989. 2. Thonar, E. J-M. A., J.M. Williams, M.B.E. Sweet, B.A. Maldonado, M.E. Lenz, T.J.Schnitzer and K.E. Kuettner. Studies of the Metabolism of Keratan Sulphate-Bearing Proteoglycans of Cartilage. In: Keratan Sulphate: Chemistry, Biology, Chemical Pathology", Greiling H and Scott JE, editors. British Biochemical Society, London, pp. 184-190, 1989. 3. Thonar, E. J-M. A., J.M. Williams, M.E. Lenz, M.B.E. Sweet, L. Otten, G. Campion, T.J. Schnitzer and K.E. Kuettner. Measurement of serum keratan sulfate provides important information about the metabolism of cartilage proteoglycans in vivo. In: Methods in Cartilage Research", (Maroudas, A. and Kuettner, K.E. eds.), Academic Press, New York, pp. 345-347, 1990. 4. Mettal, D., Scheuplein, F., Enzmann, H., Brune, K., Lenz, M.E., Thonar, E.J-M.A., Williams, J.,Mollenhauer, J.:Humorale Reaktionen bei spontanen und experimentell induzierten rheumatischen Gelenkerankungen.In: Gelenkzerstorung bei Entzundlichen Rheumatisahen Erkrankungen (Joint Destruction in Inflammatory Rheumatoid Diseases - Basic Mechanisms and Their Modulation by Therapy.) Edited by von Winfried and K.H. Emmert. Steinkopff Verlag Darmstadt, pp. 91-100, 1990. 5. Thonar, E. J-M. A., J.M. Williams, B.A. Maldonado, M.E. Lenz, T. Schnitzer, G.V. Campion and K.E. Kuettner. Serum keratan sulfate concentration as a measure of the catabolism of cartilage proteoglycans. In: Monoclonal Antibodies and Immunotherapy in Arthritis. Clinical and Experimental Aspects. (T. Kressina, Ed.), Marcel Dekker, Inc., New York, New York, pp. 373- 398, 1991. 6. Thonar, E.J-M.A., D.M. Manicourt, J.M. Williams, M.E. Lenz, M.B.E. Sweet, T.J. Schnitzer, L. Otten, T.T. Glant, and K.E. Kuettner. Serum keratan sulfate: a measure of cartilage proteoglycan metabolism. In: Articular Cartilage and Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J. G. Peyron and V.C. Hascall, Eds.) Raven Press, New York, pp 429-445, 1992. 7. Williams, J.M. D.R. Ongchi, D. Uebelhart, K.E. Kuettner and E.J-M.A. Thonar. Animal models of cartilage repair. In: Articular Cartilage and Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J. G. Peyron and V.C. Hascall, Eds.) Raven Press, New York, pp 511-526, 1992. 8. Thonar, E.J-M.A., M.E. Lenz, K. Masuda, L. Wang, D.M. Manicourt and J.M. Williams. Serum markers of cartilage changes in osteoarthritis. In: Osteoarthritic Disorders. (K.E. Kuettner and V. M. Goldberg, Eds.) American Academy of Orthopaedic Surgeons. Rosemont, IL pp 445-456, 1995. Abstracts: 1. Williams, J.M. and B.L. O'Connor. The effects of anterior cruciate ligament section and exercise on rat articular cartilage. Anat Rec 196:205A, 1980. 2. Williams, J.M. and B.L. O'Connor. The effects of partial articular nerve transection on the articular cartilage and subchondral bone of rat knee joints. Anat Rec 199:277A, 1981. 3. Williams, J.M. and K.D. Brandt. Iodoacetate (IA) causes osteoarthritis in guinea pigs. Anat Rec 202:204A, 1982. 4. Myers, S., T. Christine and J. Williams. The synovial villus in organ culture: a new system for the study of synovial cell function. Arthritis Rheum 25 Suppl S98, 1982. 5. Williams J.M. and K.D. Brandt. Effect of immobility on formation of osteophytes after intraarticular injection of iodoacetate (IA). Clin Res 30:810A, 1982. Selected for Fellows Award, American Rheumatism Association Central Society. 6. Williams, J.M. and K.D. Brandt. Exercise increases osteophyte formation but protects against fibrillation following iodoacetate (IA) induced cartilage damage. Arthritis Rheum 27: S52, 1984. 7. Williams, J.M. and K.D. Brandt. Protection by coricosteroids against chemically induced articular cartilage damage and osteophyte formation. Arthritis Rheum 28:S50, 1985. 8. Smith, G.N. Jr., J.M. Williams, and K.D. Brandt. Interaction of proteoglycans with the pericellular (1 alpha,2 alpha,3 alpha) collagens of cartilage. Orthop Trans 155,1985. 9. Williams, J.M. and K.D. Brandt. Intraarticular corticosteroids protect against chemicallyinduced articular cartilage damage and osteophyte formation. Clin Res 33:593A, 1985. 10. Smith, G.N, Jr., J.M. Williams and K.D. Brandt. Interaction between soluble 1 alpha, 2 alpha 3 alpha collagen and sulfated polyanions. Clin Res 33:884A, 1985. 11. Williams, J.M., E.J-M.A. Thonar, M. Dimuzio and K.E. Kuettner. Early formation of osteophytes following chemically-induced articular cartilage injury. Orthop Trans 10:358, 1986. 12. Williams, J.M. and R.G. Peterson. Composition of the posterior articular nerve of the rat knee joint. .Anat Rec 214:144A, 1986. 13. Williams J.M., R.J. Katz, D. Childs and E. J-M. A. Thonar. Topographical variations in proteoglycans from osteophytic and articular cartilage. Anat Rec 218:148A, 1987. 14. Williams, J.M. Tibial osteophyte formation after chemically-induced articular cartialge injury. Anat Rec 218:149A, 1987. 15. Dworksy, B.D. and J.M. Williams. Effects of long term chemically-induced articular cartilage injury. Anat Rec 218:38A, 1987. 16. Williams, J.M., C. Downey, E. J-M. A. Thonar. Elevated serum keratan sulfate in experimentalarthritis. Arthritis Rheum 30 Suppl S128, 1987. 17. Williams, J.M., C. Downey, E. J-M. A. Thonar. The concentration of serum keratan sulfate increases several fold following the loss of articular proteoglycans from a single rabbit knee joint.. Orthop Trans 13:156, 1988. 18. Fassbender, K., D. Pietryla, M. DiMuzio, M.E. Lenz, T.J. Schnitzer, J.M. Williams, K.E. Kuettner and E.J-M. A. Thonar. Affinity of cationic proteins of small and high molecular weights for anionic components of the extracellular matrix of articular cartilage. Orthop Trans 14:156, 1989. 19. Maldonado, B.A., J.M. Williams, L.M. Otten, M. Flannery, K.E. Kuettner and E.J-M.A. Thonar. Differences in the rate of clearance of different KS-bearing molecules injected intravenously in rabbits. Orthop Trans 14:161, 1989. 20. Hennessy, R.M., J.M. Williams, J.R. Kuszak, V. Young and K.E. Kuettner. Spontaneous Osteoarthritis in Guinea Pig Knees. Anat Rec 223:50A, 1989. 21. Williams, J.M., J.R. Kuszak, V. Young and K.E. Kuettner. Intra-articular iodoacetate induced articular cartilage injury in the rabbit knee. Anat Rec 223:124A, 1989. 22. Kiester, D., G.B.J. Andersson, T.W. McNeil, J. Williams and E.J-M.A. Thonar. Is the effect of chymopapain on disc proteoglycans dose related? Proc Int Society Lumbar Spine 27, 1989 and Ann Meeting North American Spine Society Trans 17-18, 1989. 23. Williams, J.M., M.E. Moran, E.J-M.A. Thonar and R.B. Salter. Stimulated repair of articular cartilage following matrix proteoglycan loss. Glycoconjugate J 6:451, 1989. 24. Williams, J.M., M.E. Moran, E.J-M.A. Thonar and R.B. Salter. Continuous passive motion stimulates repair of rabbit knee articular cartilage following matrix proteoglycan loss. Orthop Trans 15:127, 1990. 25. Williams, J.M., D.R. Ongchi and E. J-M. A. Thonar, Non-rigid immobilization preserves the integrity of rabbit knee and ankle articular cartilage. Anat Rec 226:110A, 1990. 26. Williams, J.M., Kiester, D., E.J-M.A. Thonar and G.B.J. Andersson. Is the effect of chymopapain on disc proteoglycans dose related? Orthop Trans 16:356, 1991. 27. Bewsey, K., J.M. Williams and G.A. Homandberg. Fibronectin fragments mediated damage to joint cartilage. Anat Rec 229:39-40A, 1991. 28. Williams, J.M., J. Zurwaski and T.T. Glant. Functional assessment of joint use in experimental inflammatory murine arthritis. Anat Rec 229:92A, 1991. 29. Zurawski, J., D.R. Ongchi and J.M. Williams. The in vivo effects of dimethyl sulfoxide (DMSO) on normal and chemically-injured joint tissues. Anat Rec 229:97A, 1991. 30. Ishiguro, N., D. Uebelhart, E.J-M.A. Thonar and J.M. Williams. Immunolocalization of atypical chondroitin sulfate chains reacting with the 3-B-3 monoclonal antibodies following chymopapain-induced injury in the rabbit. Orthop Trans 17:278, 1992. 31. Uebelhart, D., E.J-M.A. Thonar, D.W. Pietryla, D.R. Ongchi and J.M. Williams. Pyridinium crosslinks are increased in urine of rabbits injected intra-articularly with chymopapain. Orthop Trans 17:275, 1992. 32. J. Mollenhauer, C. Franzelius, A. Schulmeister, E.J-M.A. Thonar, J.M. Williams and K. Brune. Autoantibodies to chondrocyte membrane proteins in osteoarthritis and experimental animalarthritis. In: Articular Cartilage and Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J. G. Peyron and V.C. Hascall, Eds.) Raven Press, New York, pp. 708-709, 1992. 33. Ongchi, D.R., E.J-M.A. Thonar, C. Johnson, J.M. Williams and T.J. Schnitzer. Keratan sulfate content of synovial fluid after knee injury. In: Articular Cartilage and Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J. G. Peyron and V.C. Hascall, Eds.) Raven Press, New York, pp. 734-735, 1992. 34. Uebelhart, D., E.J-M.A. Thonar, D.W. Pietryla, A. Chantraine and J.M. Williams. Pyridinium crosslinks are markers of bone and cartilage degradation in rabbits injected intra-articularly with chymopapain. Proc Fed Eur Conn Tiss Soc 20/31, 1992 and Osteoarthritis and Cartilage 1:65,1992. 35. Williams, J.M., J. Zurwaski, K. Mikecz, T.T. Glant. Changes in joint function in experimental murine arthritides. Arthritis Rheum 35:S329, 1992. 36. Chen L-M., J.M. Williams, B.R. Bach, Jr., D. Manicourt and E.J-M.A. Thonar. Regional differences in the rise in blood levels of keratan sulfate and hyaluronan after chymopapain- induced knee joint injury. Orthop Trans: 18:712, 1993. 37. Williams, J.M. Animal models of articular cartilage repair. Abst Japan Rheumat Assoc. 37:255, 1993. 38. Xiao F, A Chong, P Foster, JM Williams, D Frieders, H Sankary, L McChesney, JW Williams.Leflunomide on acute rejection in hamster to rat cardiac xenografts. Proc. Amer. Soc. Transplant Surgeons 20th Annual Meeting, page 117, 1994. 39. Glant TT, RR Bartlett, K Mikecz, JM Williams, R Schleyerbach. Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide. (1993 meetings, Vienna, Austria, October 10-16, 1993.) 40. Williams, JM, J Vasarhely, D Uebelhart, EJ-MA Thonar, ME Lenz and L Modis. The spatial orientation of the collagen network of articular cartilage is altered in rabbits following intra-articular chymopapain injection. Orthop Trans 19:455, 1994. 41. Plaza VL, EJ-MA Thonar, KE Kuettner, JM Williams. Influence of sodium hyaluronic acid on osteophyte formation in experimental arthritis. Osteoarthritis and Cartilage 2:59, 1994. 42. Plaza VL, G Homandberg, F Hui, KE Kuettner, JM Williams. Intra-articular sodium hyaluronic acid partially blocks fibronectin fragment (Fn-f) mediated cartilage injury in vivo. Osteoarthritis and Cartilage 2:59, 1994. 43. G Homandberg, F Hui, JM Williams, KE Kuettner. Hyaluronic acid (ARTZ) suppresses fibronectin fragment mediated cartilage chondrolysis in vitro. Osteoarthritis and Cartilage 2:56, 1994. 44. Homandberg G, VL Plaza, F Hui, KE Kuettner and JM Williams. Hyaluronic acid (ARTZ) suppresses fibronectin fragment (Fn-f) mediated cartilage injury. Osteoarthritis and Cartilage 2:15, 1994. 45. Plaza VL, EJ-MA Thonar, JM Williams. Intra-articular injections of hyaluronan reduce chondrocyte loss and prevent osteophyte formation in the rabbit knee joint after chymopapain- induced injury. Orthop Trans 20:305, 1995. 46. Rayan V, EJ-MA Thonar, X Yi, JM Williams. In vivo effects of intra-articular chymopapain injury on articular cartilage of skeletally mature rabbits. Orthop Trans 20:358, 1995. 47. Homandberg GA, JM Williams, KE Kuettner. Fibronectin fragment induction of cartilage chondrolysis in vitro and in vivo and inhibition by hyaluronan. (presented at the Internationaler Expertenworkshop, Berlin, Jan 27-29, 1995-in press). 48. Plaza VL, V Rayan, EJ-MA Thonar and JM Williams. Long term protective effect of a high molecular weight hyaluronic acid (HA) in an animal model of articular cartilage injury. Arthritis Rheum 38:Suppl 9:S161, 1995. 48. Arsenis C, C Muehleman, J Williams, K Huch, T Schmid, KE Kuettner and A Cole. Morphological and Biochemical Studies on the Articular Cartilage of the Joints of the Foot. Trans Combined Orthopaedic Research Society 2:331, 1995. 49. Chiba K, K Masuda, GBL Anderson, L Wang, L Otten, D Pietryla, ME Lenz, JM Williams, S Momohara and EJ-MA Thonar. Nucleus Pulposus and Annulus Fibrosus Cells Cultered in Alginate: Characterization of Matrix Metabolism in Different Compartments. Trans Combined Orthopaedic Research Society 2:32, 1995. 50. Plaza, VL, V Rayan, EJ-MA Thonar, DG Karwo and JM Williams. Efectos tardios de la terapia con acido hialuronico de alto peso molecular en cartilage articular lesionado experimentalmente. (in press-presented at the XV Annual Meeting of SBR: Biological Society of Rosario, November 23, 1995, Rosario, Argentina.) 51. Rayan V, VL Plaza, EJ-MA Thonar, DG Karwo and JM Williams. Early Effects of Intra- articular Chymopapain Injury on Adolescent Rabbit Knee Joints. Orthop Trans 21:316, 1996. 52. Williams JM, VL Plaza, J Wen, DG Karwo and G Homandberg. Short and Long Term Effects of Multiple Intra-articular Injections of Fibronectin Fragments on the Articular Cartilage of Adolescent Rabbits. Orthop Trans 21:313, 1996. 53. Momohara S, K Masuda, ME Lenz, VL Plaza, K Chiba, JM Williams and EJ-MA Thonar. Synthesis and Turnover of Populations of Proteoglycans Synthesized by Adult Meniscal Cells and Articular Chondrocytes in Alginate Beads. Orthop Trans 21:17, 1996. 54. Chiba K, GBJ Andersson, K Masuda, JM Williams, S Momohara and EJ-MA Thonar. A New Culture System to Study the Metabolism of a Whole Intervertebral Disc In Vitro.. Orthop Trans 21: 190, 1996. 55. Chiba K, GBJ Andersson, K Masuda, S Momohara, JM Williams, and EJ-MA Thonar. A Comparison of the Effectiveness of Intervertebral Disc Tissues and Cells Exposed to Chondroitinase ABC and Chymopapain to Reform a Matrix. Orthop Trans 22: 150, 1997. 56. Uebelhart D., Zhang J., Thonar EJ-MA, Williams, JM. "Acute Degradation of Articular Cartilage in the Rabbit: Protective Effect of Chondroitin 4 and 6 Sulfate" Osteoarthritis and Cartilage 5:68,supplementA,1997. 57. Wachsmuth L., Raiss R.X., Williams J.M., Zhang J., and Homandberg G. Chondrolysis in Rat Knee Joints Following Injection of Rat or Rabbit Fibronectin Fragments (submitted to the 1998 annual meetings of the Orthopaedic Research Society). 58. Williams, J.M., Wachsmuth L. , Zhang, J. Raiss, R.X., and Homandberg, G. Cartilage Injury and Restoration of Matrix Proteoglycans Following Multiple Intra-articular Injections of Fibronectin Fragments. (submitted to the 1998 annual meetings of the Orthopaedic Research Society). 59. Kuo, E.C., Williams, J.M., A.A. Romeo. Cysts of the humeral head: a sign of rotator cuff disease or normal anatomy? . (submitted to the 1998 annual meetings of the Orthopaedic Research Society). 60. Homandberg, G.A., Kang, Y., Kuettner, K.E., J.M. Williams. "Hyaluronic acid suppresses fibronectin fragment mediated damage to human cartilage in explant cultures" . (submitted to the 1998 annual meetings of the Orthopaedic Research Society). Reviewer: Reviewer of submitted manuscripts for: Arthritis and Rheumatism The Journal of Orthopaedic and Sports Physical Therapy. The Journal of Orthopaedic Research Matrix Calcified Tissue International Connective Tissue Research The Anatomical Record The Journal of Arthroplasty Invited presentations: Local and State Meetings. 1. Repair of articular cartilage after chemically-induced injury. Department of Oral Anatomy. University of Illinois, May 10, 1984. 2. The Neurology of the Synovial Joint. The DuPage Easter Seal Treatment Center, Villa Park, IL, May 6, 1986. 3. Elevated serum keratan sulfate levels in experimental arthritis. Chosen to represent The Graduate College at The University Committee on Research Symposium during University Research Week, Rush Presbyterian St. Luke's Medical Center. April 28, 1987. 4. Workshop Participant: Surgery of the Hand in Cerebral Palsy. The DuPage Easter Seal Treatment Center, Villa Park, IL, October 10-11, 1987. 5. Role of the Anatomist in a Biomedical Setting. Department of Biology, Wheaton College, November 12, 1987. 6. Workshop Participant: Management of the Hand in Cerebral Palsy. The DuPage Easter Seal Treatment Center, Villa Park, IL, February 20-21, 1988. 7. Stimulated repair of articular proteoglycan loss. Chosen to represent The Rush Medical College at The University Committee on Research Symposium during University Research Week, Presbyterian St. Luke's Medical Center, April 17, 1990. 8. Careers in Biomedical Research. Career Expo. York Community High School. Elmhurst, Illinois. October 9, 1990. 9. Experimental Models of Arthritis: Early Detection and Repair. New Horizons in Health. 5th Annual Midwest Seminar. October 27, 1990. Sponsored by the A. Keith Brewer Foundation, Inc. 10. Careers in Biomedical Research. Career Expo. York Community High School. Elmhurst, Illinois. October, 10, 1991. 11. Anatomy and Physiology of the Human Breast as it Relates to Breastfeeding. Metropolitan Illinois Lactation Consultants, October 17, 1991. 12. Current Research in Osteoarthritis. Fourth Annual Gerontology Institute, Illinois Geriatric Education Center, University of Illinois at Chicago, Chicago, Illinois, May 15, 1992. 13. Functional Anatomy of the Human Breast as it Relates to Breastfeeding. Medela Corporation, McHenry, Illinois. November 16, 1992. 14. Anatomy of the Human Breast. Presented at "Breastfeeding: The First Step in Affordable Health Care." Rush University College of Nursing at the Rush Presbyterian St. Luke's MedicalCenter, Chicago, IL, February 25, 1994. 15. Workshop "On being the parent of a child with a disability." University of Illinois School of Physical Therapy. September 13, 1994. 16. A presentation on "The life of a scientist" to the Acclerated Chemistry and Advanced Placement Biology classes at the York Community High School, Elmhurst, IL. Instructor Dennis Smithenry, November 15, 1995. 17. A presentation on "Careers in Science" to the Medical Careers class at the York Community High School, Elmhurst, IL. Instructor - Katie Feigh,, November 22, 1996. 18. "Anatomy and Physiology of Human Lactation" Presented in the course NUR 511, Basic Concepts in Human Lactation of Breastfeeding." Rush University College of Nursing at the Rush Presbyterian St. Luke's Medical Center, Chicago, IL, December 12, 1996. National Meetings. 1. Repair of Articular cartilage after Injury. Department of Anatomy, Louisiana State University School of Medicine, New Orleans, February 4, 1986. 2. Panel Moderator. Bone Session. American Association of Anatomists Meetings, Washington, D.C., May 10-14, 1987. 3. The Neurology of the Synovial Joint. Neuroscience and Inflammation Group. CIBA-GEIGY, Summit, New Jersey. May 11, 1988. 4. Two models of chemically-induced articular cartilage damage. Inflammation Research Association, New York Academy of Sciences. New York, NY. May 12, 1988. 5. Stimulated repair of articular cartilage following matrix proteoglycan loss. Midwest Connective Tissue Workshop, Ann Arbor, November 4-5, 1989. 6. Experimental articular cartilage injury and repair. Department of Anatomy. Indiana University,January 15, 1991. 7. Articular cartilage injury and repair. Merck Sharp and Dohme. February 4, 1991. Rahway, New Jersey. 8. Panel Moderator. Skeletal and Cranial Anatomy Session. American Association of Anatomists Meetings, Chicago, IL, April 20-24, 1991. 9. Degradation and Repair of Proteoglycans in Cartilage after the Intra-articular Injection of Chymopapain into Rabbits. Merck, Sharp and Dohme Symposium on Degradation and Repair of Cartilage in Arthritis. September 4-6, 1991. Red Bank, New Jersey. 10. The Repair of Articular Cartilage. Intermedics Orthopaedics. Austin, Texas. October 12, 1992. 11. Experimentally-induced models of articular cartilage injury and repair. Greenwich Pharmaceuticals, Inc., Ft. Washington, PA, June 25, 1993. 12. The spatial orientation of the collagen network of articular cartilage is altered in rabbits following intra-articular chymopapain injection. Midwest Connective Tissue Workshop, Chicago, IL, October 22, 1993. 13. The use of intra-articular ARTZ as a chondroprotective device in chymopapain-induced articularcartilage injury. ARTZ Scientific Forum. (held in conjunction with the annual meetings of the Orthopaedic Research Society, New Orleans. February 24, 1994. 14. Experimentally-induced articular cartilage injury: The combined use of misoprostol and diclofenac as therapeutic agents. Misoprostol Research Symposium. Searle Pharmaceuticals. Deerfield Hyatt Regency. Deerfield, IL. April 14-15, 1994. 15. Animal models of cartilage injury and repair. The Department of Physical Therapy, Division of Rehabilitation Sciences, College of Allied Health, The University of Oklahoma, Oklahoma City, Oklahoma, June 16, 1995. 16. Biologic Mechanisms of Connective Tissues. IN: Management of Soft T issue Dysfunction. Course Director, Robert J. Friberg, Ph.D., PT. The Department of Physical Therapy, Division of Rehabilitation Sciences, College of Allied Health, The University of Oklahoma, Oklahoma City, Oklahoma, June 16-17, 1995.