2nd Pan-American Thalassaemia Conference May 7 – 9, 2009 – São Paulo – Brazil Preliminary Program Thursday, May 7 8h30 - Welcome and Introductions – Merula Steagall, Dr. José Orlando Bordin, Adriana Justo (FUNDATAL-Argentina), Ryiad Elbard (The Thalassaemia Foundation of Canada – Canada) & Gina Cioffi (Cooley’s Anemia Foundation - USA) 8h40 - Meeting Goals – Dr. Monica Verissimo, Dr. Sandra Loggetto and Dr. Antonio Piga 9h - Transfusion dependency: current assessment of its risks and future perspectives. - Dr. José Orlando Bordin (Unifesp – Medical School of São Paulo & SBHH - Brazilian Society of Hematology and Hemotherapy – Brazil) 9h45 - Endocrine dysfunction in thalassaemia major patients: an overview and clinical cases - speaker to be confirmed 10h30 - Coffee Break 11h - Update on survival in thalassaemia major – speaker to be confirmed 11h45 - Understanding the pathophysiology of transfusional iron loading and its difference from hereditary hemochromatosis - Dr. Renzo Galanello (Cagliari University - Italy) 12h30 - LUNCH 14h - Transfusional Iron overload: is it all the same? What are the differences in iron loading and its morbidity in thalassaemia major, sickle cell and MDS patients who are transfusion dependent? - speaker to be confirmed 14h30 - Iron chelation: how does it work, how we would like it to work. – speaker to be confirmed 15h - Iron chelation: a review of their efficacy in the clinical practice. - Dr. Antonio Piga (University of Torino – Italy) 15h30 - Iron chelation: adverse events and their management. confirmed – speaker to be 16h - Adverse Events with iron chelators: discussion of clinical cases. Chair: Dr. Isaac Odame (The Hospital for Sick Children – Canada) Deferoxamine: Dr. Giorgio Baldanzi (Hemepar – Hematology and Hemotherapy Center of the State of Paraná - Brazil) Deferiprone: Dr. Sandra Loggetto (Hematology Center of the State of São Paulo Brazil) Combination therapy: Dr. Monica Veríssimo (Boldrini Children’s Center – Brazil) Deferasirox: Dr. Antonio Fabron (Hemocenter, Faculty of Medicine of Marília – Brazil) 17h - Networking and Nutrition Break Friday, May 8 8h30 - Stem cell transplantation and gene therapy in thalassaemia: an update – speaker to be confirmed 9h15 - Thalassaemia Intermedia: Clinical aspects and management – Prof. Dr. Renzo Galanello (Cagliari University - Italy) 10h - Coffee Break 10h30 - Renal dysfunction in Thalassaemia: pathophysiology, assessment and management.- Dr. Sunil Bhandari (Hull Royal Infirmary – United Kingdom) 11h15 - Iron overload: does it has a role in the prognosis of hepatitis C? - speaker to be confirmed 12h - LUNCH 14h - Cardiac Dysfunction in Thalassaemia major - Dr. Malcolm Walker (University College London Hospital – United Kingdom) 14h45 - MRI: Its role in the management of iron overload – Dr. Juliano Lara Fernandes (UNICAMP - University of Campinas – Brazil) & Dr. Laercio Alberto Rosemberg 15h30 - Pulmonary hypertension - Dr. Malcolm Walker (University College London Hospital – United Kingdom) 16h - CLINICAL CASES - In this section, clinical cases will be presented by doctors who would like to discuss some aspect in the management of their patients Interactive session Chair: Dr. Isaac Odame (The Hospital for Sick Children – Canada) All the specialists will participate in this section 16h45 - Networking and Nutrition Break Saturday, May 9 8h30 - Hemoglobin F modulation in thalassemias (UNICAMP - University of Campinas – Brazil) - Prof Dr Fernando Costa 9h - Iron chelation in sickle cell disease - Dr Monica Veríssimo (Boldrini Children’s Center – Brazil) 9h30 - Iron chelation in hemochromatosis Faculty of Medicine of Marília – Brazil) - Dr Antonio Fabron (Hemocenter, 10h - Coffee Break 10h30 - CLINICAL CASES - In this section, clinical cases will be presented by doctors who would like to discuss some aspect in the management of their patients Interactive session All the specialists will participate in this section. 11h15 - Splenectomy: when should it be indicated? - Dr. Renzo Galanello (Cagliari University - Italy) 11h45 - Fertility and pregnancy in thalassaemia? - Dr. Antonio Piga (University of Torino – Italy) 12h15 - Closing Remarks Dr. Monica Veríssimo, Dr. Sandra Logetto, Dr. Antonio Piga & Merula Steagall 12h45 - Lunch