References

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RESULTS 2007

SYNTHESIS OF THE WORK

Project no. 301/1.10.2007

SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF NEW ORGANIC

COMPOUNDS FROM HETEROCYCLIC CONDENSED SYSTEMS WITH BRIDGEHEAD

NITROGEN

NURC Code: ID_226

Director: PROF. DR. IOANA ŞARAMET

University of Medicine and Pharmacy Carol Davila Bucharest

Faculty of Pharmacy

Between October to December 2007, the research team had the next objectives:

1.

The study of literature data to develop optimal ways of achieving the proposed synthesis

2.

Preconditions for achieving the proposed synthesis aimed to elaborate the work protocols for the synthesis of new compounds.

Introduction

The condensed systems with bridgehead nitrogen which will be synthesized belong to thiazolo-triazoles

(I), (II) , triazolo-thiadiazoles (III) , triazolo-thiadiazines (IV), (V) . class

R

N N O

N N

N N

Ar

N

N

N

S

(Ia)

Ar

N

(Ib)

S

R

1

Ar

N

N

N

S

CH Ar

1

(II)

Ar

N

N

S

Ar

N

N

S

R

1

(IV)

Ar

2

N N

(III)

Ar

O

N

S

Ar = X S ; X= H, Cl, Br

HN

R

3 O

O

(V)

In order to achieve the synthesis of these compounds classes, the literature was studied, from which we are presenting a selective bibliography:

References

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613-616

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1058

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[1,2,4]triazolo[3,4b ][1,3,4]thiadiazines”, Russian J. Org. Chem ., 2003 , 39 (7), 1025-1028

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[49] Vainilavicius P., Smicius R., Jakubkiene V., Tumkevicius S. – „Synthesis of 5-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-

3-pyrimidinyl)-methyl-4-amino-1,2,4-triazole-3-thione and its reactions with polyfunctional electrophiles”, Monatsh. Chem .,

2001 , 132 (7), 825-831

Project Director,

Prof Dr IOANA SARAMET

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