Program Director/Principal Investigator (Last, First, Middle):
Murphy, Kenneth M.
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Murphy, Kenneth M.
Eugine Opie First Centennial Professor of
Pathology & Immunology, Director of Immunology
Program-DBBS, Investigator, Howard Hughes
Medical Institute
eRA COMMONS USER NAME (credential, e.g., agency login)
kmmurphy
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Rice University, Houston, TX
Johns Hopkins University School of Medicine,
Baltimore, MD
Washington University School of Medicine, St.
Louis, MO
Washington University School of Medicine, St.
Louis, MO
B.A.
1978
Chemistry
MD/PhD
1984
Medicine
Resident
1989
Pathology
Post-doc
1986-90
Molec Immunology
A. Personal Statement. Research in Dr. Murphy's lab focuses on the development of distinct cell lineages
within the vertebrate immune system, primarily at the transcriptional level. Current lineages of interest include
T cell subsets, dendritic cell and macrophages, and the role of the ATF family of AP-1 transcription factors in
specification of these cell types.
B. Positions and Honors
Positions and Employment
1979-1984
Ph.D. Dissertation with Dr. Solomon Snyder, Dept of Neuroscience & Pharmacology, Johns
Hopkins University School of Medicine, Baltimore, MD
1978-1984
M.D., Johns Hopkins University School of Medicine, Baltimore, MD
1984-1986
Resident in Training, Dept of Pathology, Washington University School of Medicine, Barnes
Hospital, St. Louis, MO
1986-1990
Postdoctoral training with Dr. Dennis Y. Loh, Dept of Medicine, Washington University School of
Medicine, St. Louis, MO
1988-1989
Chief Resident, Anatomic Pathology, Washington University School of Med, St. Louis, MO
1988-1989
Instructor in Pathology, Washington University School of Med, St. Louis, MO
1989-1994
Assistant Professor, Dept of Pathology, Washington University School of Med, St. Louis, MO
1994-1999
Associate Professor, Dept of Pathology, Washington University School of Med, St. Louis, MO
1997-2003
Associate Investigator, Howard Hughes Medical Institute, Washington University School of Med,
St. Louis, MO
1999-present Professor, Dept. of Pathology, Washington University School of Med, St. Louis, MO
2003-present Investigator, Howard Hughes Medical Institute, Washington University School of Med. St. Louis,
MO
Other Experience and Professional Memberships
1993-1998
ad hoc Reviewer - NIH Scientific Review Group: Immunobiology (IMB) Study Section
1998-2002
Full Member - NIH Scientific Review Group: Immunobiology (IMB) Study Section
1997-2002
AAI Program Committee
2000-2001
AAI Nominating Committee
2000-2002
Chairperson, NIH Center for Scientific Review Immunobiology (IMB) Study Section
2005-2006
AAI Nominating Committee
2008-2009
NIH Scientific Review Committee – Scientific Review Group Immunobiology (IMB)
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle):
Honors
1975-1977
1977
1978
1978
1978-1984
1984
1988-1990
2009
Murphy, Kenneth M.
Board of Governors Scholar, Rice University, Houston, TX
Phi Beta Kappa
B.A. Summa Cum Laude, Rice University, Houston, TX
Z.W. Salsburg Memorial Award, Department of Chemistry, Rice University, Houston, TX
Medical Scientist Training Program Award, Johns Hopkins Univ Sch of Medicine, Baltimore, MD
D.I. Macht Memorial Prize, Johns Hopkins University School of Medicine, Baltimore, MD
Juvenile Diabetes Foundation Career Development Award
Distinguished Investigator Award, Washington University School of Medicine
C. Selected Peer-reviewed Publications (Selected from 180 peer-reviewed publications)
Bibliography
a.
Selected Peer Reviewed Manuscripts:
1.
Murphy, K. M. and S. H. Snyder. 1981. Adenosine receptors in rat testes: labeling with 3Hcyclohexyladenosine. Life Sci 28:917-920. PM:6261066
2.
Gould, R. J., K. M. Murphy, and S. H. Snyder. 1982. [3H]nitrendipine-labeled calcium channels
discriminate inorganic calcium agonists and antagonists. Proc.Natl.Acad.Sci U.S.A 79:3656-3660.
PM:6285357
3.
Murphy, K. M. and S. H. Snyder. 1982. Heterogeneity of adenosine A1 receptor binding in brain tissue.
Mol Pharmacol 22:250-257. PM:6292687
4.
Murphy, K. M., R. J. Gould, and S. H. Snyder. 1982. Autoradiographic visualization of [3H]nitrendipine
binding sites in rat brain: localization to synaptic zones. Eur.J Pharmacol 81:517-519. PM:7117385
5.
Murphy, K. M. and S. H. Snyder. 1982. Calcium antagonist receptor binding sites labeled with
[3H]nitrendipine. Eur.J Pharmacol 77:201-202. PM:7060638
6.
Sastre, A., K. M. Murphy, and M. M. Rusher. 1982. Myocardial muscarinic acetylcholine receptor:
choline and tris unmask heterogeneity of antagonist binding sites. Biochem Biophys.Res Commun.
104:383-388. PM:7073688
7.
Gould, R. J., K. M. Murphy, and S. H. Snyder. 1983. A simple sensitive radioreceptor assay for calcium
antagonist drugs. Life Sci 33:2665-2672. PM:6319847
8.
Gould, R. J., K. M. Murphy, I. J. Reynolds, and S. H. Snyder. 1983. Antischizophrenic drugs of the
diphenylbutylpiperidine type act as calcium channel antagonists. Proc.Natl.Acad.Sci U.S.A 80:51225125. PM:6136040
9.
Murphy, K. M., R. J. Gould, M. L. Oster-Granite, J. D. Gearhart, and S. H. Snyder. 1983. Phorbol ester
receptors: autoradiographic identification in the developing rat. Science 222:1036-1038. PM:6316499
10.
Murphy, K. M. and A. Sastre. 1983. Obligatory role of a Tris/choline allosteric site in guanine nucleotide
regulation of [3H]-L-QNB binding to muscarinic acetylcholine receptors. Biochem Biophys.Res
Commun. 113:280-285. PM:6602611
11.
Murphy, K. M., R. J. Gould, B. L. Largent, and S. H. Snyder. 1983. A unitary mechanism of calcium
antagonist drug action. Proc.Natl.Acad.Sci U.S.A 80:860-864. PM:6572372
12.
Murphy, K. M., R. R. Goodman, and S. H. Snyder. 1983. Adenosine receptor localization in rat testes:
biochemical and autoradiographic evidence for association with spermatocytes. Endocrinology
113:1299-1305. PM:6311515
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Murphy, Kenneth M.
Anholt, R. R., K. M. Murphy, G. E. Mack, and S. H. Snyder. 1984. Peripheral-type benzodiazepine
receptors in the central nervous system: localization to olfactory nerves. J Neurosci. 4:593-603.
PM:6321699
14.
Gould, R. J., K. M. Murphy, I. J. Reynolds, and S. H. Snyder. 1984. Calcium channel blockade: possible
explanation for thioridazine's peripheral side effects. Am J Psychiatry 141:352-357. PM:6322598
15.
Gould, R. J., K. M. Murphy, and S. H. Snyder. 1984. Tissue heterogeneity of calcium channel
antagonist binding sites labeled by [3H]nitrendipine. Mol Pharmacol 25:235-241. PM:6422256
16.
De Souza, E. B., R. R. Anholt, K. M. Murphy, S. H. Snyder, and M. J. Kuhar. 1985. Peripheral-type
benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal,
and testis. Endocrinology 116:567-573. PM:2981667
17.
Gould, R. J., K. M. Murphy, and S. H. Snyder. 1985. Autoradiographic localization of calcium channel
antagonist receptors in rat brain with [3H]nitrendipine. Brain Res 330:217-223. PM:2985193
18.
Murphy, K. M., L. L. McLaughlin, M. L. Michener, and P. Needleman. 1985. Autoradiographic
localization of atriopeptin III receptors in rat kidney. Eur.J Pharmacol 111:291-292. PM:3160595
19.
Gould, R. J., K. M. Murphy, S. H. Snyder, J. W. Strandhoy, and C. E. Dunlap, III. 1989. Differential
interaction of guanabenz with receptor binding sites in rat brain and kidney. Res Commun.Chem.Pathol
Pharmacol 66:3-19. PM:2559439
20.
Murphy, K. M., C. T. Weaver, M. Elish, P. M. Allen, and D. Y. Loh. 1989. Peripheral tolerance to
allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonaldeletion mechanism. Proc.Natl.Acad.Sci U.S.A 86:10034-10038. PM:2513571
21.
Murphy, K. M., A. B. Heimberger, and D. Y. Loh. 1990. Induction by antigen of intrathymic apoptosis of
CD4+CD8+TCRlo thymocytes in vivo. Science 250:1720-1723. PM:2125367
22.
Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation
of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic
system. Proc.Natl.Acad.Sci U.S.A 89:6065-6069. PM:1385868
23.
Iwabuchi, K., K. Nakayama, R. L. McCoy, F. Wang, T. Nishimura, S. Habu, K. M. Murphy, and D. Y.
Loh. 1992. Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.
Proc.Natl.Acad.Sci U.S.A 89:9000-9004. PM:1409596
24.
Kanagawa, O., B. A. Nussrallah, M. E. Wiebenga, K. M. Murphy, H. C. Morse, III, and F. R. Carbone.
1992. Murine AIDS superantigen reactivity of the T cells bearing V beta 5 T cell antigen receptor. J
Immunol 149:9-16. PM:1351503
25.
Hsieh, C. S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1993. Pathogen-induced Th1 phenotype
development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent. Int.Immunol 5:371382. PM:8494824
26.
Hsieh, C. S., S. E. Macatonia, C. S. Tripp, S. F. Wolf, A. O'Garra, and K. M. Murphy. 1993.
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science
260:547-549. PM:8097338
27.
Macatonia, S. E., C. S. Hsieh, K. M. Murphy, and A. O'Garra. 1993. Dendritic cells and macrophages
are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12
substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent.
Int.Immunol 5:1119-1128. PM:7902129
28.
O'Garra, A. and K. Murphy. 1993. T-cell subsets in autoimmunity. Curr.Opin.Immunol 5:880-886.
PM:7905272
29.
Shinkai, Y., S. Koyasu, K. Nakayama, K. M. Murphy, D. Y. Loh, E. L. Reinherz, and F. W. Alt. 1993.
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science
259:822-825. PM:8430336
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Murphy, Kenneth M.
Szabo, S. J., J. S. Gold, T. L. Murphy, and K. M. Murphy. 1993. Identification of cis-acting regulatory
elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol Cell Biol
13:4793-4805. PM:8336717
31.
Wang, R., K. M. Murphy, D. Y. Loh, C. Weaver, and J. H. Russell. 1993. Differential activation of
antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the
antigen-presenting cell. J Immunol 150:3832-3842. PM:7682585
32.
Wang, R., S. I. Abrams, D. Y. Loh, C. S. Hsieh, K. M. Murphy, and J. H. Russell. 1993. Separation of
CD4+ functional responses by peptide dose in Th1 and Th2 subsets expressing the same transgenic
antigen receptor. Cell Immunol 148:357-370. PM:8098671
33.
Bucy, R. P., A. Panoskaltsis-Mortari, G. Q. Huang, J. Li, L. Karr, M. Ross, J. H. Russell, K. M. Murphy,
and C. T. Weaver. 1994. Heterogeneity of single cell cytokine gene expression in clonal T cell
populations. J Exp.Med. 180:1251-1262. PM:7523568
34.
Murphy, E. E., G. Terres, S. E. Macatonia, C. S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G.
Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and
interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J
Exp.Med. 180:223-231. PM:7516409
35.
O'Garra, A. and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function.
Curr.Opin.Immunol 6:458-466. PM:7917115
36.
Bach, E. A., S. J. Szabo, A. S. Dighe, A. Ashkenazi, M. Aguet, K. M. Murphy, and R. D. Schreiber.
1995. Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell
subsets. Science 270:1215-1218. PM:7502050
37.
Bucy, R. P., L. Karr, G. Q. Huang, J. Li, D. Carter, K. Honjo, J. A. Lemons, K. M. Murphy, and C. T.
Weaver. 1995. Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype
development. Proc.Natl.Acad.Sci U.S.A 92:7565-7569. PM:7638231
38.
Dighe, A. S., D. Campbell, C. S. Hsieh, S. Clarke, D. R. Greaves, S. Gordon, K. M. Murphy, and R. D.
Schreiber. 1995. Tissue-specific targeting of cytokine unresponsiveness in transgenic mice. Immunity
3:657-666. PM:7584155
39.
Hosken, N. A., K. Shibuya, A. W. Heath, K. M. Murphy, and A. O'Garra. 1995. The effect of antigen
dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J
Exp.Med. 182:1579-1584. PM:7595228
40.
Hsieh, C. S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background
determines default T helper phenotype development in vitro. J Exp.Med. 181:713-721. PM:7836924
41.
Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K.
M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine
phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp.Med.
181:1755-1762. PM:7722452
42.
Macatonia, S. E., N. A. Hosken, M. Litton, P. Vieira, C. S. Hsieh, J. A. Culpepper, M. Wysocka, G.
Trinchieri, K. M. Murphy, and A. O'Garra. 1995. Dendritic cells produce IL-12 and direct the
development of Th1 cells from naive CD4+ T cells. J Immunol 154:5071-5079. PM:7730613
43.
Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of
interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol 15:5258-5267.
PM:7565674
44.
Openshaw, P., E. E. Murphy, N. A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995.
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T
helper 2 populations. J Exp.Med. 182:1357-1367. PM:7595206
45.
Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental
commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665-675. PM:7796298
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Murphy, Kenneth M.
Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature
383:787-793. PM:8893001
47.
Cleveland, M. G., J. D. Gorham, T. L. Murphy, E. Tuomanen, and K. M. Murphy. 1996. Lipoteichoic
acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway.
Infect.Immun. 64:1906-1912. PM:8675286
48.
Gorham, J. D., M. L. Guler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Frederick, W. F. Dietrich, and K.
M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2
type responses. Proc.Natl.Acad.Sci U.S.A 93:12467-12472. PM:8901605
49.
Guler, M., K. Murphy, and J. Gorham. 1996. Response: Resistance to Leishmania major in Mice.
Science 274:1392b-1393b. PM:17772042
50.
Guler, M. L., J. D. Gorham, C. S. Hsieh, A. J. Mackey, R. G. Steen, W. F. Dietrich, and K. M. Murphy.
1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development. Science
271:984-987. PM:8584935
51.
Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra.
1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp.Med.
183:901-913. PM:8642294
52.
Wenner, C. A., M. L. Guler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-gamma
and IFN-alpha in IL-12-induced T helper cell-1 development. J Immunol 156:1442-1447. PM:8568246
53.
Gorham, J. D., M. L. Guler, and K. M. Murphy. 1997. Genetic control of interleukin 12 responsiveness:
implications for disease pathogenesis. J Mol Med. 75:502-511. PM:9253713
54.
Guler, M. L., N. G. Jacobson, U. Gubler, and K. M. Murphy. 1997. T cell genetic background
determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1
phenotype development. J Immunol 159:1767-1774. PM:9257839
55.
Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R
beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp.Med. 185:817-824.
PM:9120387
56.
Wenner, C. A., S. J. Szabo, and K. M. Murphy. 1997. Identification of IL-4 promoter elements conferring
Th2-restricted expression during T helper cell subset development. J Immunol 158:765-773.
PM:8992993
57.
Gorham, J. D., M. L. Guler, D. Fenoglio, U. Gubler, and K. M. Murphy. 1998. Low dose TGF-beta
attenuates IL-12 responsiveness in murine Th cells. J Immunol 161:1664-1670. PM:9712029
58.
Murphy, K. M. 1998. T lymphocyte differentiation in the periphery. Curr.Opin.Immunol 10:226-232.
PM:9602313
59.
Ouyang, W., S. H. Ranganath, K. Weindel, D. Bhattacharya, T. L. Murphy, W. C. Sha, and K. M.
Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent
mechanism. Immunity 9:745-755. PM:9846495
60.
Ranganath, S., W. Ouyang, D. Bhattarcharya, W. C. Sha, A. Grupe, G. Peltz, and K. M. Murphy. 1998.
GATA-3-dependent enhancer activity in IL-4 gene regulation. J Immunol 161:3822-3826. PM:9780146
61.
Shibuya, K., D. Robinson, F. Zonin, S. B. Hartley, S. E. Macatonia, C. Somoza, C. A. Hunter, K. M.
Murphy, and A. O'Garra. 1998. IL-1 alpha and TNF-alpha are required for IL-12-induced development
of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice. J Immunol
160:1708-1716. PM:9469428
62.
Carter, L. L. and K. M. Murphy. 1999. Lineage-specific requirement for signal transducer and activator
of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells. J Exp.Med.
189:1355-1360. PM:10209051
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Murphy, Kenneth M.
Grakoui, A., D. L. Donermeyer, O. Kanagawa, K. M. Murphy, and P. M. Allen. 1999. TCR-independent
pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization. J
Immunol 162:1923-1930. PM:9973460
64.
Guler, M. L., J. D. Gorham, W. F. Dietrich, T. L. Murphy, R. G. Steen, C. A. Parvin, D. Fenoglio, A.
Grupe, G. Peltz, and K. M. Murphy. 1999. Tpm1, a locus controlling IL-12 responsiveness, acts by a
cell-autonomous mechanism. J Immunol 162:1339-1347. PM:9973388
65.
Guler, M. L., J. D. Gorham, W. F. Dietrich, R. G. Steen, C. Parvin, D. Fenoglio, A. Grupe, G. Peltz, and
K. M. Murphy. 1999. Loci influencing development of Th responses. Identification from in vitro analysis.
Microbes Infect. 1:79-88. PM:10847770
66.
Murphy, K. M., W. Ouyang, S. Ranganath, and T. L. Murphy. 1999. Bi-stable transcriptional circuitry
and GATA-3 auto-activation in Th2 commitment. Cold Spring Harb.Symp.Quant.Biol 64:585-588.
PM:11232335
67.
Ouyang, W., N. G. Jacobson, D. Bhattacharya, J. D. Gorham, D. Fenoglio, W. C. Sha, T. L. Murphy,
and K. M. Murphy. 1999. The Ets transcription factor ERM is Th1-specific and induced by IL-12 through
a Stat4-dependent pathway. Proc.Natl.Acad.Sci U.S.A 96:3888-3893. PM:10097133
68.
Randolph, D. A., C. J. Carruthers, S. J. Szabo, K. M. Murphy, and D. D. Chaplin. 1999. Modulation of
airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of
asthma. J Immunol 162:2375-2383. PM:9973518
69.
Seavitt, J. R., L. S. White, K. M. Murphy, D. Y. Loh, R. M. Perlmutter, and M. L. Thomas. 1999.
Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.
Mol Cell Biol 19:4200-4208. PM:10330160
70.
Yang, J., T. L. Murphy, W. Ouyang, and K. M. Murphy. 1999. Induction of interferon-gamma production
in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation. Eur.J Immunol 29:548555. PM:10064070
71.
Farrar, J. D. and K. M. Murphy. 2000. Type I interferons and T helper development. Immunol Today
21:484-489. PM:11071526
72.
Farrar, J. D., J. D. Smith, T. L. Murphy, and K. M. Murphy. 2000. Recruitment of Stat4 to the human
interferon-alpha/beta receptor requires activated Stat2. J Biol Chem. 275:2693-2697. PM:10644731
73.
Farrar, J. D., J. D. Smith, T. L. Murphy, S. Leung, G. R. Stark, and K. M. Murphy. 2000. Selective loss
of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat
Immunol 1:65-69. PM:10881177
74.
Glimcher, L. H. and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper
lymphocyte grows up. Genes Dev. 14:1693-1711. PM:10898785
75.
Moser, M. and K. M. Murphy. 2000. Dendritic cell regulation of TH1-TH2 development. Nat Immunol
1:199-205. PM:10973276
76.
Murphy, K. M., W. Ouyang, J. D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T. L.
Murphy. 2000. Signaling and transcription in T helper development. Annu.Rev Immunol 18:451-494.
PM:10837066
77.
Murphy, T. L., E. D. Geissal, J. D. Farrar, and K. M. Murphy. 2000. Role of the Stat4 N domain in
receptor proximal tyrosine phosphorylation. Mol Cell Biol 20:7121-7131. PM:10982828
78.
Ouyang, W., M. Lohning, Z. Gao, M. Assenmacher, S. Ranganath, A. Radbruch, and K. M. Murphy.
2000. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and
commitment. Immunity 12:27-37. PM:10661403
79.
Asnagli, H. and K. M. Murphy. 2001. The functional genomics experience (are you experienced?). Nat
Immunol 2:826-828. PM:11526395
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Murphy, Kenneth M.
Farrar, J. D., W. Ouyang, M. Lohning, M. Assenmacher, A. Radbruch, O. Kanagawa, and K. M.
Murphy. 2001. An instructive component in T helper cell type 2 (Th2) development mediated by GATA3. J Exp.Med. 193:643-650. PM:11238595
81.
Hurov, J. B., T. S. Stappenbeck, C. M. Zmasek, L. S. White, S. H. Ranganath, J. H. Russell, A. C.
Chan, K. M. Murphy, and H. Piwnica-Worms. 2001. Immune system dysfunction and autoimmune
disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol 21:3206-3219. PM:11287624
82.
Ranganath, S. and K. M. Murphy. 2001. Structure and specificity of GATA proteins in Th2 development.
Mol Cell Biol 21:2716-2725. PM:11283251
83.
Yang, J., H. Zhu, T. L. Murphy, W. Ouyang, and K. M. Murphy. 2001. IL-18-stimulated GADD45 beta
required in cytokine-induced, but not TCR-induced, IFN-gamma production. Nat Immunol 2:157-164.
PM:11175814
84.
Zhou, M., W. Ouyang, Q. Gong, S. G. Katz, J. M. White, S. H. Orkin, and K. M. Murphy. 2001. Friend of
GATA-1 represses GATA-3-dependent activity in CD4+ T cells. J Exp.Med. 194:1461-1471.
PM:11714753
85.
Zhu, H., J. Yang, T. L. Murphy, W. Ouyang, F. Wagner, A. Saparov, C. T. Weaver, and K. M. Murphy.
2001. Unexpected characteristics of the IFN-gamma reporters in nontransformed T cells. J Immunol
167:855-865. PM:11441092
86.
Afkarian, M., J. R. Sedy, J. Yang, N. G. Jacobson, N. Cereb, S. Y. Yang, T. L. Murphy, and K. M.
Murphy. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat
Immunol 3:549-557. PM:12006974
87.
Asnagli, H., M. Afkarian, and K. M. Murphy. 2002. Cutting edge: Identification of an alternative GATA-3
promoter directing tissue-specific gene expression in mouse and human. J Immunol 168:4268-4271.
PM:11970965
88.
Farrar, J. D., H. Asnagli, and K. M. Murphy. 2002. T helper subset development: roles of instruction,
selection, and transcription. J Clin.Invest 109:431-435. PM:11854312
89.
Murphy, K. M. and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat Rev Immunol 2:933944. PM:12461566
90.
Nguyen, A., W. R. Burack, J. L. Stock, R. Kortum, O. V. Chaika, M. Afkarian, W. J. Muller, K. M.
Murphy, D. K. Morrison, R. E. Lewis, J. McNeish, and A. S. Shaw. 2002. Kinase suppressor of Ras
(KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol
22:3035-3045. PM:11940661
91.
Arora, T., B. Liu, H. He, J. Kim, T. L. Murphy, K. M. Murphy, R. L. Modlin, and K. Shuai. 2003. PIASx is
a transcriptional co-repressor of signal transducer and activator of transcription 4. J Biol Chem.
278:21327-21330. PM:12716907
92.
Cho, J. Y., V. Grigura, T. L. Murphy, and K. Murphy. 2003. Identification of cooperative monomeric
Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. Int.Immunol
15:1149-1160. PM:13679385
93.
Gavrieli, M., N. Watanabe, S. K. Loftin, T. L. Murphy, and K. M. Murphy. 2003. Characterization of
phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required
for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem Biophys.Res Commun.
312:1236-1243. PM:14652006
94.
Kemper, C., A. C. Chan, J. M. Green, K. A. Brett, K. M. Murphy, and J. P. Atkinson. 2003. Activation of
human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421:388-392.
PM:12540904
95.
Watanabe, N., M. Gavrieli, J. R. Sedy, J. Yang, F. Fallarino, S. K. Loftin, M. A. Hurchla, N. Zimmerman,
J. Sim, X. Zang, T. L. Murphy, J. H. Russell, J. P. Allison, and K. M. Murphy. 2003. BTLA is a
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lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4:670-679.
PM:12796776
96.
Zang, X., P. Loke, J. Kim, K. Murphy, R. Waitz, and J. P. Allison. 2003. B7x: a widely expressed B7
family member that inhibits T cell activation. Proc.Natl.Acad.Sci U.S.A 100:10388-10392. PM:12920180
97.
Berenson, L. S., N. Ota, and K. M. Murphy. 2004. Issues in T-helper 1 development--resolved and
unresolved. Immunol Rev 202:157-174. PM:15546392
98.
Berenson, L. S., J. D. Farrar, T. L. Murphy, and K. M. Murphy. 2004. Frontline: absence of functional
STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha. Eur.J
Immunol 34:2365-2374. PM:15307169
99.
Ota, N., T. J. Brett, T. L. Murphy, D. H. Fremont, and K. M. Murphy. 2004. N-domain-dependent
nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat Immunol 5:208-215.
PM:14704793
100.
Chen, C., W. Ouyang, V. Grigura, Q. Zhou, K. Carnes, H. Lim, G. Q. Zhao, S. Arber, N. Kurpios, T. L.
Murphy, A. M. Cheng, J. A. Hassell, V. Chandrashekar, M. C. Hofmann, R. A. Hess, and K. M. Murphy.
2005. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature
436:1030-1034. PM:16107850
101.
Cheung, T. C., I. R. Humphreys, K. G. Potter, P. S. Norris, H. M. Shumway, B. R. Tran, G. Patterson,
R. Jean-Jacques, M. Yoon, P. G. Spear, K. M. Murphy, N. S. Lurain, C. A. Benedict, and C. F. Ware.
2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus
entry mediator cosignaling pathway. Proc.Natl.Acad.Sci U.S.A 102:13218-13223. PM:16131544
102.
Harrington, L. E., R. D. Hatton, P. R. Mangan, H. Turner, T. L. Murphy, K. M. Murphy, and C. T.
Weaver. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T
helper type 1 and 2 lineages. Nat Immunol 6:1123-1132. PM:16200070
103.
Hurchla, M. A., J. R. Sedy, M. Gavrieli, C. G. Drake, T. L. Murphy, and K. M. Murphy. 2005. B and T
lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in
anergic CD4+ T cells. J Immunol 174:3377-3385. PM:15749870
104.
Koo, T. B., H. Song, I. Moon, K. Han, C. Chen, K. Murphy, and H. Lim. 2005. Differential expression of
the PEA3 subfamily of ETS transcription factors in the mouse ovary and peri-implantation uterus.
Reproduction 129:651-657. PM:15855628
105.
Persky, M. E., K. M. Murphy, and J. D. Farrar. 2005. IL-12, but not IFN-alpha, promotes STAT4
activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2
gene. J Immunol 174:294-301. PM:15611252
106.
Sedy, J. R., M. Gavrieli, K. G. Potter, M. A. Hurchla, R. C. Lindsley, K. Hildner, S. Scheu, K. Pfeffer, C.
F. Ware, T. L. Murphy, and K. M. Murphy. 2005. B and T lymphocyte attenuator regulates T cell
activation through interaction with herpesvirus entry mediator. Nat Immunol 6:90-98. PM:15568026
107.
Sparks-Thissen, R. L., D. C. Braaten, K. Hildner, T. L. Murphy, K. M. Murphy, and H. W. Virgin. 2005.
CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma.
Virology 338:201-208. PM:15961135
108.
Tao, R., L. Wang, R. Han, T. Wang, Q. Ye, T. Honjo, T. L. Murphy, K. M. Murphy, and W. W. Hancock.
2005. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of
partially versus fully MHC-mismatched cardiac allografts. J Immunol 175:5774-5782. PM:16237069
109.
Barchet, W., J. D. Price, M. Cella, M. Colonna, S. K. MacMillan, J. P. Cobb, P. A. Thompson, K. M.
Murphy, J. P. Atkinson, and C. Kemper. 2006. Complement-induced regulatory T cells suppress T-cell
responses but allow for dendritic-cell maturation. Blood 107:1497-1504. PM:16239430
110.
Berenson, L. S., M. Gavrieli, J. D. Farrar, T. L. Murphy, and K. M. Murphy. 2006. Distinct characteristics
of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol 177:5195-5203.
PM:17015705
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Berenson, L. S., J. Yang, B. P. Sleckman, T. L. Murphy, and K. M. Murphy. 2006. Selective
requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1
responses. J Immunol 176:4616-4621. PM:16585552
112.
Deppong, C., T. I. Juehne, M. Hurchla, L. D. Friend, D. D. Shah, C. M. Rose, T. L. Bricker, L. P.
Shornick, E. C. Crouch, T. L. Murphy, M. J. Holtzman, K. M. Murphy, and J. M. Green. 2006. Cutting
edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are
required for termination of acute allergic airway inflammation. J Immunol 176:3909-3913. PM:16547224
113.
Gavrieli, M., J. Sedy, C. A. Nelson, and K. M. Murphy. 2006. BTLA and HVEM cross talk regulates
inhibition and costimulation. Adv.Immunol 92:157-185. PM:17145304
114.
Gavrieli, M. and K. M. Murphy. 2006. Association of Grb-2 and PI3K p85 with phosphotyrosile peptides
derived from BTLA. Biochem Biophys.Res Commun. 345:1440-1445. PM:16725108
115.
Hatton, R. D., L. E. Harrington, R. J. Luther, T. Wakefield, K. M. Janowski, J. R. Oliver, R. L. Lallone, K.
M. Murphy, and C. T. Weaver. 2006. A distal conserved sequence element controls Ifng gene
expression by T cells and NK cells. Immunity 25:717-729. PM:17070076
116.
Hess, R. A., P. S. Cooke, M. C. Hofmann, and K. M. Murphy. 2006. Mechanistic insights into the
regulation of the spermatogonial stem cell niche. Cell Cycle 5:1164-1170. PM:16721062
117.
Lindsley, R. C., J. G. Gill, M. Kyba, T. L. Murphy, and K. M. Murphy. 2006. Canonical Wnt signaling is
required for development of embryonic stem cell-derived mesoderm. Development 133:3787-3796.
PM:16943279
118.
Murphy, K. M. 2006. Stress management for T helper differentiation. Nat Immunol 7:553-555.
PM:16715064
119.
Murphy, K. M., C. A. Nelson, and J. R. Sedy. 2006. Balancing co-stimulation and inhibition with BTLA
and HVEM. Nat Rev Immunol 6:671-681. PM:16932752
120.
Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli, and K. M. Murphy. 2006. Th17: an effector
CD4 T cell lineage with regulatory T cell ties. Immunity 24:677-688. PM:16782025
121.
Hippenmeyer, S., R. M. Huber, D. R. Ladle, K. Murphy, and S. Arber. 2007. ETS transcription factor
Erm controls subsynaptic gene expression in skeletal muscles. Neuron 55:726-740. PM:17785180
122.
Hurchla, M. A., J. R. Sedy, and K. M. Murphy. 2007. Unexpected role of B and T lymphocyte attenuator
in sustaining cell survival during chronic allostimulation. J Immunol 178:6073-6082. PM:17475832
123.
Lepenies, B., K. Pfeffer, M. A. Hurchla, T. L. Murphy, K. M. Murphy, J. Oetzel, B. Fleischer, and T.
Jacobs. 2007. Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral
malaria. J Immunol 179:4093-4100. PM:17785848
124.
Morrow, C. M., C. E. Hostetler, M. D. Griswold, M. C. Hofmann, K. M. Murphy, P. S. Cooke, and R. A.
Hess. 2007. ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood
testes barrier function and testicular immune privilege. Ann.N.Y.Acad.Sci 1120:144-151. PM:17911411
125.
Simon, L., G. C. Ekman, G. Tyagi, R. A. Hess, K. M. Murphy, and P. S. Cooke. 2007. Common and
distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for
spermatogonial stem cell maintenance. Exp.Cell Res 313:3090-3099. PM:17574550
126.
Truong, W., J. C. Plester, W. W. Hancock, J. Kaye, S. Merani, K. M. Murphy, T. L. Murphy, C. C.
Anderson, and A. M. Shapiro. 2007. Negative and positive co-signaling with anti-BTLA (PJ196) and
CTLA4Ig prolongs islet allograft survival. Transplantation 84:1368-1372. PM:18049125
127.
Truong, W., J. C. Plester, W. W. Hancock, S. Merani, T. L. Murphy, K. M. Murphy, J. Kaye, C. C.
Anderson, and A. M. Shapiro. 2007. Combined coinhibitory and costimulatory modulation with antiBTLA and CTLA4Ig facilitates tolerance in murine islet allografts. Am J Transplant 7:2663-2674.
PM:17983390
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Weaver, C. T. and K. M. Murphy. 2007. T-cell subsets: the more the merrier. Curr.Biol 17:R61-R63.
PM:17240331
129.
Wilker, P. R., J. R. Sedy, V. Grigura, T. L. Murphy, and K. M. Murphy. 2007. Evidence for carbohydrate
recognition and homotypic and heterotypic binding by the TIM family. Int.Immunol 19:763-773.
PM:17513880
130.
De Trez, C., K. Schneider, K. Potter, N. Droin, J. Fulton, P. S. Norris, S. W. Ha, Y. X. Fu, T. Murphy, K.
M. Murphy, K. Pfeffer, C. A. Benedict, and C. F. Ware. 2008. The inhibitory HVEM-BTLA pathway
counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J Immunol
180:238-248. PM:18097025
131.
Deppong, C., J. M. Degnan, T. L. Murphy, K. M. Murphy, and J. M. Green. 2008. B and T lymphocyte
attenuator regulates T cell survival in the lung. J Immunol 181:2973-2979. PM:18713967
132.
Eo, J., K. Han, K. Murphy, H. Song, and H. Lim. 2008. ERM, an ETS transcription factor, is expressed
in granulosa and cumulus cells and serves as a transcriptional regulator of the cyclooxygenase-2. J
Endocrinol. PM:18492810
133.
Hildner, K., B. T. Edelson, W. E. Purtha, M. Diamond, H. Matsushita, M. Kohyama, B. Calderon, B. U.
Schraml, E. R. Unanue, M. S. Diamond, R. D. Schreiber, T. L. Murphy, and K. M. Murphy. 2008. Batf3
deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science
322:1097-1100. PM:19008445
134.
Lindsley, R. C., J. G. Gill, T. L. Murphy, E. M. Langer, M. Cai, M. Mashayekhi, W. Wang, N. Niwa, J. M.
Nerbonne, M. Kyba, and K. M. Murphy. 2008. Mesp1 coordinately regulates cardiovascular fate
restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell 3:55-68.
PM:18593559
135.
Nelson, C. A., M. D. Fremont, J. R. Sedy, P. S. Norris, C. F. Ware, K. M. Murphy, and D. H. Fremont.
2008. Structural determinants of herpesvirus entry mediator recognition by murine B and T lymphocyte
attenuator. J Immunol 180:940-947. PM:18178834
136.
Ong, C. T., J. R. Sedy, K. M. Murphy, and R. Kopan. 2008. Notch and presenilin regulate cellular
expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One. 3:e2823.
PM:18665263
137.
Oya, Y., N. Watanabe, T. Owada, M. Oki, K. Hirose, A. Suto, S. Kagami, H. Nakajima, T. Kishimoto, I.
Iwamoto, T. L. Murphy, K. M. Murphy, and Y. Saito. 2008. Development of autoimmune hepatitis-like
disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte
attenuator. Arthritis Rheum. 58:2498-2510. PM:18668554
138.
Schlesser, H. N., L. Simon, M. C. Hofmann, K. M. Murphy, T. Murphy, R. A. Hess, and P. S. Cooke.
2008. Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial
stem cell loss, and fertility in mice. Biol Reprod. 78:483-489. PM:18032421
139.
Steinberg, M. W., O. Turovskaya, R. B. Shaikh, G. Kim, D. F. McCole, K. Pfeffer, K. M. Murphy, C. F.
Ware, and M. Kronenberg. 2008. A crucial role for HVEM and BTLA in preventing intestinal
inflammation. J Exp.Med. 205:1463-1476. PM:18519647
140.
Tao, R., L. Wang, K. M. Murphy, C. C. Fraser, and W. W. Hancock. 2008. Regulatory T cell expression
of herpesvirus entry mediator suppresses the function of B and T lymphocyte attenuator-positive
effector T cells. J Immunol 180:6649-6655. PM:18453584
141.
Wilker, P. R., M. Kohyama, M. M. Sandau, J. C. Albring, O. Nakagawa, J. J. Schwarz, and K. M.
Murphy. 2008. Transcription factor Mef2c is required for B cell proliferation and survival after antigen
receptor stimulation. Nat Immunol 9:603-612. PM:18438409
142.
Cheung, T. C., L. M. Oborne, M. W. Steinberg, M. G. Macauley, S. Fukuyama, H. Sanjo, C. D'Souza,
P. S. Norris, K. Pfeffer, K. M. Murphy, M. Kronenberg, P. G. Spear, and C. F. Ware. 2009. T cell
intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding
microenvironment. J Immunol 183:7286-7296. PM:19915044
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Cheung, T. C., M. W. Steinberg, L. M. Oborne, M. G. Macauley, S. Fukuyama, H. Sanjo, C. D'Souza,
P. S. Norris, K. Pfeffer, K. M. Murphy, M. Kronenberg, P. G. Spear, and C. F. Ware. 2009.
Unconventional ligand activation of herpesvirus entry mediator signals cell survival. Proc.Natl.Acad.Sci
U.S A 106:6244-6249. PM:19332782
144.
Kohyama, M., W. Ise, B. T. Edelson, P. R. Wilker, K. Hildner, C. Mejia, W. A. Frazier, T. L. Murphy, and
K. M. Murphy. 2009. Role for Spi-C in the development of red pulp macrophages and splenic iron
homeostasis. Nature 457:318-321. PM:19037245
145.
McCartney, S., W. Vermi, S. Gilfillan, M. Cella, T. L. Murphy, R. D. Schreiber, K. M. Murphy, and M.
Colonna. 2009. Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated
activation of mouse NK cells. J Exp.Med. 206:2967-2976. PM:19995959
146.
Morrow, C. M., G. Tyagi, L. Simon, K. Carnes, K. M. Murphy, P. S. Cooke, M. C. Hofmann, and R. A.
Hess. 2009. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the
transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod. 81:871879. PM:19571261
147.
Saraiva, M., J. R. Christensen, M. Veldhoen, T. L. Murphy, K. M. Murphy, and A. O'Garra. 2009.
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and
ERK MAP kinase activation by high antigen dose. Immunity 31:209-219. PM:19646904
148.
Schraml, B. U., K. Hildner, W. Ise, W. L. Lee, W. A. Smith, B. Solomon, G. Sahota, J. Sim, R. Mukasa,
S. Cemerski, R. D. Hatton, G. D. Stormo, C. T. Weaver, J. H. Russell, T. L. Murphy, and K. M. Murphy.
2009. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 460:405-409.
PM:19578362
149.
Sun, Y., N. K. Brown, M. J. Ruddy, M. L. Miller, Y. Lee, Y. Wang, K. M. Murphy, K. Pfeffer, L. Chen, J.
Kaye, and Y. X. Fu. 2009. B and T lymphocyte attenuator tempers early infection immunity. J Immunol
183:1946-1951. PM:19587015
150.
Truong, W., W. W. Hancock, J. C. Plester, S. Merani, D. C. Rayner, G. Thangavelu, K. M. Murphy, C.
C. Anderson, and A. M. Shapiro. 2009. BTLA targeting modulates lymphocyte phenotype, function, and
numbers and attenuates disease in nonobese diabetic mice. J Leukoc.Biol 86:41-51. PM:19383625
151.
Tyagi, G., K. Carnes, C. Morrow, N. V. Kostereva, G. C. Ekman, D. D. Meling, C. Hostetler, M.
Griswold, K. M. Murphy, R. A. Hess, M. C. Hofmann, and P. S. Cooke. 2009. Loss of Etv5 decreases
proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave
of spermatogenesis. Biol Reprod. 81:258-266. PM:19369650
152.
Albring,J.C., Sandau,M.M., Rapaport,A.S., Edelson,B.T., Satpathy,A., Mashayekhi,M., Lathrop,S.K.,
Hsieh,C.S., Stelljes,M., Colonna,M., Murphy,T.L., Murphy,K.M. 2010. Targeting of B and T lymphocyte
associated (BTLA) prevents graft-versus-host disease without global immunosuppression. J Exp. Med.
PM:21078889
153.
Bar-On, L., T. Birnberg, K. L. Lewis, B. T. Edelson, D. Bruder, K. Hildner, J. Buer, K. M. Murphy, B.
Reizis, and S. Jung. 2010. CX3CR1+ CD8{alpha}+ dendritic cells are a steady-state population related
to plasmacytoid dendritic cells. Proc.Natl.Acad.Sci U.S A. PM:20679228
154.
Edelson, B. T., W. Kc, R. Juang, M. Kohyama, L. A. Benoit, P. A. Klekotka, C. Moon, J. C. Albring, W.
Ise, D. G. Michael, D. Bhattacharya, T. S. Stappenbeck, M. J. Holtzman, S. S. Sung, T. L. Murphy, K.
Hildner, and K. M. Murphy. 2010. Peripheral CD103+ dendritic cells form a unified subset
developmentally related to CD8{alpha}+ conventional dendritic cells. J Exp.Med. PM:20351058
155.
Ise, W., M. Kohyama, K. M. Nutsch, H. M. Lee, A. Suri, E. R. Unanue, T. L. Murphy, and K. M. Murphy.
2010. CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cellextrinsic mechanisms. Nat Immunol 11:129-135. PM:20037585
156.
Owada, T., N. Watanabe, M. Oki, Y. Oya, Y. Saito, T. Saito, I. Iwamoto, T. L. Murphy, K. M. Murphy,
and H. Nakajima. 2010. Activation-induced accumulation of B and T lymphocyte attenuator at the
immunological synapse in CD4+ T cells. J Leukoc.Biol 87:425-432. PM:19892849
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Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS,
Hofmann MC. 2010. Etv5 Regulates Sertoli Cell Chemokines Involved in Mouse Stem/Progenitor
Spermatogonia Maintenance. Stem Cells PM:20799334
D. Research Support
OTHER SUPPORT
MURPHY, KENNETH M.
OTHER SUPPORT
MURPHY, KENNETH M.
ACTIVE
Howard Hughes Medical Institute
9/1/10-8/31/11
Investigator
$706,449
Title of Research: Signaling in Lymphocyte Development
Major goal of this research is to study receptors and signaling pathways that control the development and activation of
lymphocytes.
Dr. Murphy does not receive salary support from grants, his salary is provided from HHMI funds.
5 U19 AI070489-03 (Holtzman)
7/1/06-6/30/11
2.10 calendar
NIH/NIAID
$185,412 (Proj 3); $141,365 (Core A) 17.5% (17.5%)
AADCRC Innate and Adaptive Immune Signaling in Asthma
The major goals of this project are to understand how innate and adaptive immune signals contribute to the
pathogenesis of asthma and thereby develop new therapeutic strategies for this condition. Project 3 will continue the
theme for immune balance and the proposal that a deficiency in turning off the immune response could lead to an
excessive and prolonged inflammatory response to allergic and other stimuli.
Role: Core A, Co-Director (Administration), 0.30 calendar, 2.5% effort
Project 3, Co-Investigator, 1.80 calendar, 15% effort
5 R01 AI076427-02 (Murphy)
6/5/09-5/31/11
1.80 calendar
NIH/NIAID/ARRA
$274,239
15% (15%)
Analysis of Bidirectional Signaling Mechanisms for BTLA and HVEM in Autoimmunity
The major goals of this project are to analyze the inhibitory and pro-survival options of BTLA in vivo and distinguish
cell-intrinsic from cell-autonomous mechanisms.
W81XWH-09-1-0185 (Murphy/Gillanders) 5/1/09-4/30/11
1.20 calendar
DOD Synergystic Idea Award
$125,000
10% effort (10%)
Defining the Role of BTLA in Breast Cancer Immunosurveillance and Selective Targeting of the BTLA-HVEM-Light
Constimulatory System
The major goals of this project is that BTLA contributes to the inhibition of breast cancer immunosurveillance, and
selective targeting of the BTLA-Light-HVEM costimlatory system can enhance breast cancer immunity.
Role on Project: Partnering PI
OVERLAP
None.
PHS 398/2590 (Rev. 06/09)
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Program Director/Principal Investigator (Last, First, Middle):
PHS 398/2590 (Rev. 06/09)
Murphy, Kenneth M.
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