SUMMARY OF STATISTICS OF ANIMAL USE IN RESEARCH AND TEACHING VICTORIA REPORT NUMBER 29 1 JANUARY 2011 TO 31 DECEMBER 2011 1. INTRODUCTION This document presents salient aspects of animal use in research and education in Victoria in graphical form. Information for 2011 is set within the context of previous years’ data in order to demonstrate trends of use through time. Details are available in the publications “Statistics of Animal Experimentation Victoria” for the appropriate years. Data were collected from all institutions licensed to use animals in research and education in Victoria under the Prevention of Cruelty to Animals Act 1986 (the Act). Animal use is conducted in projects, where each project is run by a chief investigator and is approved by an Animal Ethics Committee. An “Animal Use Return” form that describes project methodologies and animal usage is required to be submitted each year for each project (Regulation 100, Prevention of Cruelty to Animals Regulations 2008). Specified animal is a term defined in the Act that means mouse, rat, rabbit, or guinea pig other than a mouse, rat, rabbit bred in its native habitat, and non-human primate (i.e. laboratory animals). 2. SELECTED DETAILS OF NUMBERS OF ANIMALS USED Number of animals 1, 1, 2, 00 50 00 0, 0, 0, 00 00 00 0 0 0 Animal Use By Year Animals excl. fish Fish 0 50 0, 00 0 2004: +2,177,247 additional poultry 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 Year Graph 1. Total animal use, 2002 to 2011. The total number of animals used in 2011 was 2,614,472 . Of these, 778,759 were fish, first counted in 2004. A single poultry project used 1,000,000 birds in 2011. Specified Mouse Use By Year 600,000 Number of mice 500,000 400,000 300,000 200,000 100,000 0 2002 2003 2004 2005 2006 Year 2007 2008 2009 2010 2011 Graph 2. Specified mouse use, 2002 to 2011. There were 585,875 specified mice used in 2011, compared to the long-term average of 363,805 Specified Rat, Guinea Pig And Rabbit Use By Year Guinea Pig 2002 2004 2005 2006 2007 2008 2009 2010 2, 75 3 1, 55 8 1, 31 4 2, 81 9 2, 39 8 2, 67 1 2, 43 5 2, 76 3 2003 2, 49 5 Rabbit (numbered) 2, 66 5 Number of animals Rat 45,000 40,000 35,000 30,000 25,000 20,000 15,000 10,000 5,000 0 2011 Year Graph 3. Specified animal use excluding mice and non-human primate, 2002 to 2011. A total of 39,881 specified rats, guinea pigs, and rabbits were used in 2011, compared to the long-term average of 46,322. These were composed of 29,030 rats (average of 39,589); 8,098 guinea pigs (average of 7,386); and 2,753 rabbits (average of 2,346). Number of animals Primate Use by Year 300 Marmosets 250 Macaques Baboon (numbered) 200 150 100 50 4 4 3 4 2 2007 2008 2009 0 2002 2003 2004 2005 2006 2010 2011 Year Graph 4. Primate use, 2002 to 2011. Three hundred and thirteen non-human primates were used in 2011, compared to a long-term average of 128. These were composed of 244 marmosets (average of 71), and 69 macaques (average of 55). One ‘Other primate’ was used in 2002 that is not represented here. The above average number of marmosets in 2011 is due to 2 projects using 145 animals in studies of social behaviour. 3. SELECTED ASPECTS OF ANIMAL USAGE Proportion Of Animals Used By Project Mission Animals used (%) 60 50 2007 2008 2009 2010 2011 (numbered) 48 40 27 30 17 20 10 2 6 0 Educational objectives The improvement of animal management or production Environmental objectives Project mission Graph 5. Animal use by project mission for the last 5 years (rounded). Maintenance or improvement of human or animal health and welfare The understanding of human or animal biology Animals Used In Genetic Modification Procedures 350 100,000 80,000 Number of animals 300 Number of projects 250 Number of projects Number of animals 120,000 200 60,000 150 40,000 100 20,000 50 0 0 2004 2005 2006 2007 2008 2009 2010 2011 Year Graph 6. Animals used in genetic modification procedures, 2004 to 2011. Three hundred and twelve projects used 107,729 animals in genetic modification in 2011. Meaningful data are only available from 2004 due to a change in the way data were collected. Animals used (%) Proportion Of Animals Used By Category Of Procedure 70 60 50 40 30 20 10 0 58 2007 2008 2009 2010 2011 (numbered) 18 7 9 4 2 Observational Animal unconscious without recovery Minor Minor surgery conscious with recovery intervention, no anaesthesia Minor physiological challenge 2 Surgery with recovery 0.3 Physiological Death as an end challenge point Category of Procedure Graph 7. Animal use by category of procedure for the last 5 years (rounded). The large proportion of animals in physiological challenge procedures in 2008 and 2009 reflects relatively high impact analyses of large numbers of fish in commercial fisheries. Proportion Of Animals Used By Source 41 Animals used (%) 45 40 2007 2008 2009 2010 2011 (numbered) 35 30 25 27 24 20 15 10 4 5 3 1 0 Licensed source (laboratory animals) Own derivation (non-laboratory) Commercial provider Animals on a privately owned farm Natural habitat Removed from natural habitat Other (non lab) Source Graph 8. Animal use by source for the last 5 years (sources representing less than 1% of animal use not included). The commercial provider figure is skewed by a single project using 1 million poultry Year Number of animals in death as an end-point procedures Number of projects using death as an endpoint procedures 2004 2005 2006 2007 2008 2009 2010 2011 6,280 799 360 251 471 327 2,315 6,935 9 6 3 4 10 9 8 29 Table 1. Numbers of animals used in death as an end-point procedures and projects with death as an end-point procedures, 2004 and 2011. Twenty nine projects used 6,935 animals in death as an end-point procedures in 2011. Data on this procedure type prior to 2004 are inaccurate due to inappropriate application of the “death as an end-point” term by licences. 4. SPECIFIED ANIMALS IN BREEDING COLONIES Year Type of Animal (non-GM) 2006 2007 2008 2009 2010 2011 Guinea pigs 2,604 3,638 1,142 1,087 1,153 388 Macaques Marmosets Mice Rabbits Rats Total 159 173 261,697 638 31,391 296,662 203 159 237,246 527 33,407 275,180 341 135 281,875 504 42,558 326,555 225 166 344,823 515 56,993 403,809 243 177 360,185 445 52,786 414,989 250 156 365,009 489 48,543 414,835 Table 2: Specified animals in breeding colonies for scientific procedures, 2006 to 2011 (non genetically modified). Numbers not included in Graphs 1, 2, 3 or 4. Year Type of Animal (GM) Mice Rats Total 2006 2007 2008 2009 2010 2011 333,266 1,031 334,297 389,632 13,120 394,201 461,745 9,304 471,049 490,962 1,923 492,885 531,098 1,146 532,244 558,293 1,744 560,037 Table 3: Specified animals in breeding colonies for scientific procedures, 2006 to 2011 (genetically modified). Numbers not included in Graphs 1, 2, 3, or 6. Specified Mice Breeding 600,000 Genetically modified Number of mice 500,000 Non genetically modified 400,000 300,000 200,000 100,000 0 2006 2007 2008 2009 2010 Year Graph 9. Breeding of specified mice, 2006 to 2011. Numbers not included in Graphs 1, 2 or 6. 2011 5. DETAILS OF SCIENTIFIC PROCEDURE LICENCES AND PROJECTS Year 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 Number of projects 2,078 2,030 2,176 2,458 2,386 2,358 2,455 2,673 2,931 3,010 Number of licences using animals 105 107 97 99 104 110 107 111 115 123 Number of projects per licence 20 19 22 25 23 21 23 24 25 24 Table 4. Number of projects and number of licences, 2002 to 2011 licences and projects included only where animals were used). Year 2003 2004 2005 2006 2007 2008 2009 2010 2011 Number of animals used 488,808 2,780,290 (603,043) 1,560,340 1,125,487 1,207,360 1,216,393 2,255,076 1,595,375 2,614,472 (1,614,472) Number of licences using animals 107 97 99 104 110 107 111 115 123 Number of animals per licence 4,568 28,663 (6,217) 15,761 12,066 10,976 11,368 20,316 13,873 21,256 (13,126) Table 5. Number of project animals used and number of licences, 2003 to 2011(licences included only where animals were used). Figures in parentheses exclude the aberrant poultry projects in 2004 and 2011. Year 2003 2004 2005 2006 2007 2008 2009 2010 2011 Number of animals used 488,808 2,780,290 (603,043) 1,560,340 1,125,487 1,207,360 1,216,393 2,255,076 1,595,375 2,614,472 (1,614,472) Number of projects 2,030 2,176 (2,175) 2,458 2,386 2,358 2,455 2,673 2,931 3,010 (3,009) Number of animals per project 241 1,278 (277) 635 472 512 495 844 544 869 (537) Table 6. Number of project animals used and number of projects, 2003 to 2011 (projects included only where animals were used). Figures in parentheses exclude the aberrant poultry projects in 2004 and 2011.