1 CURRICULUM VITAE Name: Renuka Malik, M.D. Office Address: University of Chicago Department of Radiation and Cellular Oncology 5758 S. Maryland Ave, MC 9006 Chicago, IL 60637 E-Mail: rmalik@radonc.uchicago.edu Medical License/Certification: 08/2010 State of Illinois, 036125277 08/2010 DEA, FM1951424 06/2011 Board Certification in Radiation Oncology (American Board of Radiology) Education: 1998-2001 University of Illinois at Chicago Chicago, IL Guaranteed Pre-Professional Honors Program in Medicine (Seven-year program with direct admission into medical school from high school) B.A. Philosophy; Minor: Biology Summa Cum Laude 2001-2005 University of Chicago Pritzker School of Medicine Doctor of Medicine (M.D.) Chicago, IL Postdoctoral Training: Internship 2005-2006 Resurrection Medical Center Transitional Year Chief Resident Chicago, IL Residency 2006-2010 University of Chicago Hospitals Department of Radiation and Cellular Oncology Co-Chief Resident (2008-2009) Chicago, IL Externships 02/2009 Princess Margaret Hospital Department of Radiation Oncology Toronto, Canada Positions and Appointments: 2 8/2010-present Clinical Instructor, Department of Radiation Oncology and Cellular Oncology University of Chicago, Chicago, IL 4/2012-present Department of Radiation and Cellular Oncology Quality Chair Scientific and Medical Societies: 2006-present American Society of Therapeutic Radiology and Oncology Honors and Awards: 1999, 2000 Illinois State General Assembly Scholar (Two-time full tuition scholarship recipient) 2000 Chicago Circle Physics Scholar (Awarded to top introductory physics student) 2000 Rhodes Scholarship Competition, Illinois State Finalist (Selected as one of nine state finalists) 2001 University of Illinois Honors College Distinguished Senior Student Award (Awarded to one graduating Honors College student) 2001 Avery Brundage Scholarship for Academics and Amateur Athletics 2001 Honors Council Award 2001 University of Illinois Alumni Association Leadership Award 2001 Chancellor’s Student Service Award 2001 Phi Eta Sigma (Scholarship Recipient) 2001 Phi Beta Kappa, Phi Kappa Phi 2005 University of Chicago, School of Medicine Fentress Research Scholar Award 2005 University of Chicago, Department of Radiation and Cellular Oncology Senior Medical Student Award 2010 American Brachytherapy Society Nucletron HDR Fellowship Recipient (Awarded to 10 Radiation Oncology residents annually) Presentations: 1997 Malik R, Pack G. “Twisting and Turning of DNA: Nucleosome Modeling” Oral Presentation, University of Illinois College of Medicine Summer Research Internship Forum, Rockford, IL 3 2002 Malik R, Lavey R. “Late Effects of Cranial or Spinal Radiation Therapy on Growth, Thyroid, and Anti-Diuretic Hormones.” Oral Presentation, Children’s Hospital of Los Angeles, Los Angeles, CA 2003 Malik R, Lavey R. “Late Effects of Cranial or Spinal Radiation Therapy on Growth, Thyroid and Anti-Diuretic Hormones.” Poster, Pediatric Academic Societies Annual Meeting, Seattle, WA 2004 Malik R, Oh J, Roeske JC, Mundt AJ. “Resident Education in IntensityModulated Radiation Therapy.” Oral Presentation, American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Outcomes Scientific Session, Philadelphia, PA 2005 Malik R, Mell L, Mundt AJ. “Effect of Amifostine on Response Rates in Locally Advanced Non-Small-Cell Lung Cancer Patients treated on randomized controlled trials: a Meta-Analysis.” Oral Presentation, American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Outcomes Scientific Session, Denver, CO 2006 Malik R, Mell L, Mundt AJ. “Effect of Amifostine on Response Rates in Locally Advanced Non-Small-Cell Lung Cancer Patients treated on randomized controlled trials: a Meta-Analysis.” Oral Presentation, University of Chicago Pritzker School of Medicine, Fentress Research Forum, Chicago, IL 2007 Malik R, Cloutier D, Liauw SL. “Can External Beam Radiation Therapy for Prostate Carcinoma Help Improve Urinary Symptoms in Men with High IPSS Scores?” Oral Presentation, American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Quality of Life Scientific Session, Los Angeles, CA 2008 Malik R, Jani AB, Liauw SL. “PSA ‘Halving-Time’ during Neoadjuvant ADT and Prior to Radiotherapy is Associated with Biochemical Control in Men with Localized Prostate Cancer.” Oral Presentation, American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, GU Scientific Session, Boston, MA 2010 Malik R, Correa D, Liauw SL. "The Influence of Time to Radiotherapy after Biopsy on Biochemical Control in Men with Localized Prostate Cancer." Poster Presentation, American Radium Society Meeting, Cancun, Mexico 2010 Khodarev NN, Pitroda SP, Wakim BT, Golden D, Beckett MA, Mauceri HJ, Sutton HG, Perakis S, Malik R, Wietholt C, Pelizzari C, Chen C, Weichselbaum RR. “STAT1-dependent Expression of Genes and Proteins Involved in Energy Metabolism Links Tumor Growth and Radioresistance to the Warburg Effect and Predicts Poor Prognosis in Cancer Patients” Poster Presentation, American Association for Cancer Research Meeting (AACR), 04/2010 4 2010 Malik R, Haraf DJ, Pederson AW, Choe KS, Witt ME, Salama JK, Cohen EE, Blair EA, Stenson KM, Cohen EE, Vokes, EE. “Impact of Induction Chemotherapy on Treatment Outcomes in Advanced Head and Neck Carcinoma Patients treated with Concurrent Chemotherapy and Hyperfractionated Radiotherapy.” Poster Presentation, American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, San Diego, CA 2011 Khodarev N; Pitroda S; Sood R; Khan R; Filippo M; Gutt R; Perakis S; Darga T; Malik R; Pederson A; Weichselbaum R. “Ionizing Radiation activates IFN signaling in tumor cells” Poster Presentation, American Association for Cancer Research Annual Meeting 2011 Hasselle M, Salama JK, Tye K, Liauw SL, Weichselbaum RR, Malik R. “Patterns of Progression following Hypofractionated Image-guided Radiotherapy to Abdominal Nodes in Oligometastatic Patients with Abdominopelvic Primary Tumors.” Poster Presentation, American Society for Therapeutic Radiology and Oncology (ASTRO), 2011 2011 Rudra S, Malik R, Ranck MC, Hasselle M, Golden D, Weichselbaum RR, Salama JK. “Hypofractionated image-guided radiation therapy for adrenal oligometastases.” Oral Presentation, Radiological Society of North America (RSNA) 2011. Invited Presentations: 2011 “Update on Clinical Trials for Patients with Advanced Distal Esophagus/GEJ Carcinoma.” Oral Presentation, 3rd Annual Gastrointestinal University of Chicago Cancer Symposium, Chicago, IL 2012 “Locally Advanced Distal Esophagus/GEJ Carcinoma.” Oral Presentation, Chicago Radiologic Society, Rush University, Chicago, IL Publications: 1. Malik R, Oh JL; Roeske JC; Mundt AJ. “Survey of Resident Education in Intensity-Modulated Radiation Therapy.” Technol Cancer Res Treat 2005; 4(3): 303-309. 2. Mell LK, Malik R, Komaki R, Movsas B, Swann SR; Langer C; Antonadou D; Koukourakis M; Mundt AJ. “Effect of Amifostine on Response Rates in Locally Advanced Non-Small-Cell Lung Cancer Patients Treated on Randomized Controlled Trials: a Meta-Analysis.” Int J Radiat Oncol Biol Phys 2007; 68(1): 111-118. 3. Malik R, Jani AB, Liauw SL. “PSA ‘Halving-Time’ during Neoadjuvant Androgen Deprivation Therapy and Prior to Radiotherapy is Associated with Biochemical Control.” Int J Radiat Oncol Biol Phys 2011; 79(4): 1022-1028. 5 4. Malik R, Jani AB, Liauw SL. “Can External Beam Radiotherapy for Prostate Cancer Help Improve Urinary Symptoms in Men With High IPSS Scores?” Int J Radiat Oncol Biol Phys 2011; 80(4): 1080-1086. Article Selected as Feature Article for Online CME 5. Shumway D; Corbin K; Salgia R; Hoffman P; Villaflor V; Malik RM; Maitland M; Haraf DJ; Vigneswaren W; Connell PP; Ferguson M; and Salama JK. “Pathologic Response Rates Following Definitive Dose Image-Guided Chemoradiotherapy Followed by Resection for Locally Advanced Non-small Cell Lung Cancer.” Lung Cancer 2011 Dec; 74(3): 446-50. 6. Salama JK; Hasselle M; Chmura SJ; Malik R; Mehta N; Yenice KM; Villaflor V; Stadler WM; Hoffman P; Cohen E; Connell P; Haraf DJ; Vokes EE; Hellman S; Weichselbaum RR “Stereotactic body radiotherapy (SBRT) for multi-site extracranial oligometastases: Final report of a dose escalation trial in patients with one to five sites of metastatic disease.” Cancer 2012 Jun 1; 118(11): 2962-70. 7. Lussier Y, Xing HR, Salama JK, Khodarev NN, Huang Y, Hasselle MD, Zhang Q, Yang X, Khan SA, Malik R, Darga TE, Fan H, Perakis S, Filippo M, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. “MicroRNA expression characterizes oligometastases.” PLoS One 2011; 6(12): e28650 Abstracts: 1. Malik R, Lavey R. “Late Effects of Cranial or Spinal Radiation Therapy on Growth, Thyroid, and Anti-Diuretic Hormones.” Proceedings of Pediatric Research, 2003 2. Malik, R, Oh JL; Roeske JC; Mundt AJ. “Resident education in Intensity-Modulated Radiation Therapy (IMRT).” Int J Radiat Oncol Biol Phys 2004; 60: S146 3. Malik R, Mell LK, Mundt AJ. “Meta-Analysis of the Effect of Amifostine on Response Rates in Advanced Non-Small Cell Lung Cancer Patients Treated on Randomized Trials.” Int J Radiat Oncol Biol Phys 2005; 63: S117 4. Malik R, Jani AB, Cloutier D, Liauw SL. “Can External Beam Radiotherapy for Prostate Cancer Help Improve Urinary Symptoms in Men With High IPSS Scores?” Int J Radiat Oncol Biol Phys 2007; 69: S30 5. Malik R, Jani AB, Liauw SL. “PSA ‘Halving-Time’ during Neoadjuvant Androgen Deprivation Therapy and Prior to Radiotherapy is Associated with Biochemical Control.” Int J Radiat Oncol Biol Phys 2008; 72: S56 6. Malik R, Correa D, Liauw SL. "The Influence of Time to Radiotherapy after Biopsy on Biochemical Control in Men with Localized Prostate Cancer." American Radium Society Meeting, 05/2010. 7. Malik R, Haraf DJ, Pederson AW, Choe KS, Witt ME, Salama JK, Cohen EE, Blair EA, 6 Stenson KM, Cohen EE, Vokes, EE. “Impact of Induction Chemotherapy on Treatment Outcomes in Advanced Head and Neck Carcinoma Patients treated with Concurrent Chemotherapy and Hyperfractionated Radiotherapy.” American Society for Therapeutic Radiology and Oncology (ASTRO) 11/2010 8. Khodarev N, Pitroda S, Sood R, Khan R, Filippo M, Gutt R, Perakis S, Darga T, Malik R, Pederson A, Weichselbaum R. “Ionizing Radiation activates IFN signaling in tumor cells” American Association for Cancer Research Annual Meeting (AACR), 2011 9. Hasselle M, Salama JK, Tye K, Liauw SL, Weichselbaum RR, Malik R. “Patterns of Progression following Hypofractionated Image-guided Radiotherapy to Abdominal Nodes in Oligometastatic Patients with Abdominopelvic Primary Tumors.” American Society for Therapeutic Radiology and Oncology Meeting (ASTRO), 2011 10. Rudra S, Malik R, Ranck MC, Hasselle M, Golden D, Weichselbaum RR, Salama JK. “Hypofractionated image-guided radiation therapy for adrenal oligometastases.” Radiological Society of North America (RSNA) 2011. Prospective Research Ongoing: 1. Phase I Study Investigating Use of Statin Therapy to Prevent Radiation Pneumonitis and Fibrosis after Definitive Treatment for Non-Small Center Lung Cancer Investigators: Dr. Sonali Rudra, Dr. Renuka Malik (PI), Dr. Joe Garcia, Dr. Ralph Weichselbaum Study Proposal Selected for ASCO/AACR Workshop: Methods in Clinical Cancer Research 2011 Status: Non-Active 2. A Long Term Investigation of Radiation Treatment in Lung Cancer Patients, Protocol: 16057A Role: Principal Investigator Prospective database is designed to assess long-term outcomes for lung cancer patients treated with definitive radiotherapy. Lung texture analysis with dose mapping is being conducted in collaboration with radiology to assess for early architectural changes correlated with symptomatic pneumonitis and to determine if these early changes lead to late fibrosis. Status: Active Committees: 2005 Selection Committee for Medical School applicants University of Chicago Pritzker School of Medicine 2007-2011 Selection Committee for Radiation Oncology Residency applicants University of Chicago, Department of Radiation and Cellular Oncology 2011-2012 Member of Technical Expert Panel for “Local Therapies for Localized Non-Small Cell 7 Lung Cancer” BlueCross Blue Shield Technology Evaluation Center Non-Academic Recognition: 1. Chicago Marathon (5th place female age-division [19 & under], top 5% female finishers), 1999 2. Chicago Half-Marathon (2nd place female age-division [19 & under]), 1999 3. Chicago Distance Classic 20K Run (1st place female age-division [19 & under]), 1999