School Postgraduate of Molecular Medicine XIV Research Report Session Warsaw, October 23 – 25, 2012 PROGRAMME October 23, 2012 (Tuesday) Warsaw Medical University Żwirki i Wigury 61 Str Senat Hall, I floor Session: MOLECULAR GENOMICS,TRANSCRIPTOMICS AND BIOINFORMATICS IN CANCER” Chairperson:Kavita Ramji 13:45-14:00 Tomasz Stokowy Molecular markers of thyroid cancer 14:00-14:15 Marcin Kruczyk Genome-wide computational modeling of STAT transcriptional network in gliomas and brain inflammation 14:15-14:30 Ewa Kurzejamska Factors affecting circulating tumor cells (CTCs) and metastasis in breast and colon cancer 14:30-14:45 Varsha Prakash Circulating tumor cells as prognostic and predictive factor in planning treatment of Colon and breast cancer using Animal models and Experimental Studies 14:45-15:00 Radosław Maksym Epigenetic modulation of genes involved in tumor and endometrial angiogenesis Chairperson:Tomasz Stokowy 15:15-15:30 Aashish Srivastava Development of novel algorithms for bioinformatics analysis of cancer-related signaling pathways 15:30-15:45 Joanna Przybył New prognostic and predictive markers for synovial sarcoma 15:40-16:00 Katarzyna Jaworska-Bieniek Influence of modifier genes on the risk of breast/ovarian cancer in BRCA1 mutation carriers – influence of modifying genes associated with selenium metabolism on the risk of breast and/or ovarian cancer in BRCA1 gene mutation carriers 16:00-16:15 Satish Gupta Influence of modifier genes on the risk of breast and/or ovarian cancer in BRAC1 mutation carriers: Influence of genes associated with selenium metabolism (pre-selected in BRCA1 carriers) on cancer risk in patients with CHEK2 mutations and unselected Lung, Larynx and Gastrointestinal cancers 16:15-16:30 Kavita Ramji STAT-dependent transcriptional network and epigenetic modifications in melanomas and lung cancer cells 16:30-16:45 Damian Matak The role of hypoxia in kidney cancer progenitor cells and kidney cancer cell lines October 24, 2012 (Wednesday) Warsaw Medical University Żwirki i Wigury 61 Str Assembly Hall, I floor Session: CANCER BIOLOGY AND THERAPY I Chairperson: Maciej Grzywnowicz 9:30-9:45 Aleksandra Markiewicz Molecular profiling of circulating tumor cells-enriched blood fraction from breast cancer patients 9:45-10:00 Dorota Kulesza Role of STAT3 in cancer cell survival and global regulation of gene expression in melanoma cells 10:00-10:15 Aleksandra Gos Molecular classification of stage III melanoma – mutational status of selected genetic markers and its influence on prognosis and therapy 10:15- 10:30 Tomasz Kucharczyk Qualification for pemetrexed therapy based on polymorphisms in thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) in non-small cell lung cancer and malignant pleural mesothelioma patients. 10:30 10:45 Łukasz Hutnik Determination of the patients pool and initial genetical analysis of children with myeloproliferative neoplasms (MPN), suspected for mutations in JAK kinase family genes 10:45-11:00 Szymon Bajon Evaluation of the influence of KAP1 gene knockdown on the phenotype and signal transduction in breast cancer stem cells". 11:00 11:15 Break Chairperson: Aleksandra Markiewicz 11:15-11:30 Maciej Grzywnowicz Programmed death-1 is a novel immunotolerant molecule expressed on leukemic B cells in chronic lymphocytic leukemia 11:30-11:45 Patrycja Sobczak KAP1 protein controls sensitivity of breast cancer stem cells to chemotherapy 11:45-12:00 Monika Kolanowska Functional analysis of newly discovered microRNA gene deregulated in Papillary Thyroid Carcinoma 12:00-12:15 Kinga Dymecka The role of microRNA genes in diagnosis of hepatocellular cancer 12:15-12:30 Marta Przestrzelska Genetic stratification of intermediate and favourable risk subgroups in Polish population of AML patients under 60 years old: evaluation of new molecular markers 12:30-13:30 Lunch Session: CANCER BIOLOGY AND THERAPY II Chairperson: Szymon Bajon 13:30-13:45 Marta Świech Functional analysis of microRNA-451 isoforoms deregulated in papillary thyroid carcinoma 13:45-14:00 Michał Kalemba Association of papillary thyroid cancer with FOXE1 gene in Polish population 14:00-14:15 Emir Ahmed Sajjad The influence of rs868 polimorphism on TGFBR1 expression 14:15-14:30 Marta Kocyk Role of glioma stem cells in shaping tumor microenvironment 14:30-14:45 Kamil Bojarczuk Transcriptional regulation of CD20 levels in B cell tumors by Src family kinases MOLECULAR BASIS OF DISEASE I Chairperson: Michał Kalemba 15:00-15:15 Magdalena Rother Regulation of immunoglobulin locus organization in developing B-cells 15:15-15:30 Michał Pruchniak Neutrophiles Extracellular Traps (NETs) in patients with autoimmune diseases - materials and methods estimation. 15:30-15:45 Klaudia Brodaczewska Effect of chitosan administration on Trichinella spiralis infection in mice 15:45-16:00 Agnieszka Skałecka mTor kinase role in dendritic arbor formation in neurons October 25, 2012 (Thursday) Warsaw Medical University Żwirki i Wigury 61 Str Senat Hall, I floor Session: MOLECULAR BASIS OF DISEASE II Chairperson: Michał Pruchniak 9:30-9:45 Kamila Caraballo Evolutionary Dynamics of the Hypervariable Region 1 (HVR1) of Hepatitis C virus (HCV) During Early Phase of Interferon Alpha and Ribavirin Therapy as a Prognostic Factor for Treatment Outcome 9:45-10:00 Natalia Kubisa Hepatitis C virus (HCV) productive infection-NS3 protein expresssion 10:00-10:15 Marta Popiel Identification of causative pathogens in viral encephalitis 10:15-10:30 Iga Turek Correlation between sirtuin 1 in leukocytes and parameters of the carbohydrate and lipid metabolism in blood in women with diagnosed gestational diabetes mellitus in the 3rd trimester ? 10:30-10:45 Karolina Antosik Unique heterozygous mutation in GLIS3 gene as a cause of permanent neonatal diabetes 10:45-11:00 Break Chairperson: Iga Turek 11:00-11:15 Dagmara Michałowska Identification of molecules responsible for inhibition of angiogenesis process in patients with critical lower limb ichemia 11:15-11:30 Anna Duszota Role of the Epstein-Barr virus in the pathogenesis of systemic lupus erythematosus 11:30:11:45 Aneta Fedorowicz Employing next-generation sequencing for the diagnosis of inherited retinal diseases: high throughput screening of ABCA4 gene mutations 11:45-12:00 Anna Misiewicz Role of KAP1 protein in reprogramming and self-renewal and differentiation of mouse induced pluripotent stem cells (iPS)