MAGNESIUM ACETATE HYDRATE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Cromosan
* Magnesium acetate
* Magnesium diacetate
AI5600000
Acetic acid, magnesium salt
142-72-3
199701
5
C4-H6-O4.Mg
142.41
QV1 &-MGMutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 111 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 29,809,1944
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84471
No. of Facilities: 737 (estimated)
No. of Industries: 12
No. of Occupations: 15
No. of Employees: 2361 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84471
No. of Facilities: 1191 (estimated)
No. of Industries: 6
No. of Occupations: 9
No. of Employees: 14996 (estimated)
No. of Female Employees: 9836 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MAGNESIUM CARBONATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
OM2470000
Magnesium(II) carbonate (1:1)
546-93-0
183480-27-5
1784-39-0
199712
22
C-O3.Mg
84.32
MG C-O3
Agricultural Chemical
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Apolda
* Carbonate magnesium
* Carbonic acid, magnesium salt
* C.I. 77713
* DCI light magnesium carbonate
* Destab
* Gold Star (carbonate)
* GP 20 (carbonate)
* Hydromagnesite
* Kimboshi
* MA 70 (carbonate)
* Magmaster
* Magnesite
* Stan-mag magnesium carbonate
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3, total dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:NUISANCE PARTICULATES
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,21,1973
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MAGNESITE, respirable fraction-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MAGNESITE, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2283
No. of Facilities: 810 (estimated)
No. of Industries: 16
No. of Occupations: 20
No. of Employees: 11547 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80144
No. of Facilities: 8724 (estimated)
No. of Industries: 81
No. of Occupations: 92
No. of Employees: 104149 (estimated)
NOES - National Occupational
NOES Hazard Code - 80144
No. of Facilities: 19943
No. of Industries: 134
No. of Occupations: 128
No. of Employees: 348034
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
53547 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MAGNESIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OM2800000
Magnesium chloride
7786-30-3
199710
20
Cl2-Mg
95.21
MG G2
Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* DUS-top
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 35,1,1929
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 35,1,1929
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
24,523,1939
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 21,257,1990
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
342 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,150,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 229 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 1,1,1909
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and
Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i
Toksikologii,
Kiev, USSR) No.11964- Volume(issue)/page/year: 9,113,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 114 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan)
V.1-
1976-
Volume(issue)/page/year: 9,291,1984
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 8000 ppm
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 6,45,1958
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
193,237,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 2 mmol/L
REFERENCE :
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th
St.,
New York, NY 10003) V.671966- Volume(issue)/page/year: 78,217,1971
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 2500 umol/kg
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11939Volume(issue)/page/year: 65,45,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 4 mmol/L
REFERENCE :
AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama,
Japan)
V.27
1973- Volume(issue)/page/year: 33,141,1979
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 43360
No. of Facilities: 2931 (estimated)
No. of Industries: 44
No. of Occupations: 37
No. of Employees: 37111 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 43360
No. of Facilities: 8597 (estimated)
No. of Industries: 89
No. of Occupations: 99
No. of Employees: 258526 (estimated)
No. of Female Employees: 138531 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MAGNESIUM CHLORIDE HEXAHYDRATE
RTECS NUMBER
: OM2975000
CHEMICAL NAME
: Magnesium chloride, hexahydrate
CAS REGISTRY NUMBER
: 7791-18-6
LAST UPDATED
: 199509
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: Cl2-Mg.6H2-O
MOLECULAR WEIGHT
: 203.33
WISWESSER LINE NOTATION : MG G2 &QH 6
COMPOUND DESCRIPTOR
: Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* Chlorure de magnesium hydrate
* CMH
* Magnesium dichloride hexahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 176 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 15,35,1929
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 31,471,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 775 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 31,471,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraarterial
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 273 gm/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
73,25,1994
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 12 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
163,63,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5658
No. of Facilities: 1678 (estimated)
No. of Industries: 14
No. of Occupations: 32
No. of Employees: 29612 (estimated)
No. of Female Employees: 16245 (estimated)
MAGNESIUM HYDROXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Asahi Glass 200-06
* Baschem 12
* Combustrol 500
:
:
:
:
:
:
:
:
:
OM3570000
Magnesium hydroxide
1309-42-8
199701
8
H2-Mg-O2
58.33
.MG..Q2
Drug
Human
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Hydro-mag MA
Ki 22-5B
Kisuma 5
Kisuma 78
Kisuma 5A
Kisuma 4AF
Kisuma 5B
Kisuma 5BG
Kisuma 5B-N
Kisuma 5E
Kisuma S 4
Kyowamag F
Lycal 96 HSE
Magmesia hydrate
Magnesia magma
Magnesiamaito
Magnesium dihydroxide
Magox
Marinco H
Marinco H 1241
Martinal VPF 8812
Milk of magnesia
Milmag
Reachim
Star 200
Versamag
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 2747 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
29,215,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1131,1990
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1131,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1131,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 815 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1131,1990
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80447
No. of Facilities: 1664 (estimated)
No. of Industries: 24
No. of Occupations: 23
No. of Employees: 41608 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80447
No. of Facilities: 3970 (estimated)
No. of Industries: 36
No. of Occupations: 55
No. of Employees: 114743 (estimated)
No. of Female Employees: 43640 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MAGNESIUM NITRATE
RTECS NUMBER
: OM3756000
CHEMICAL NAME
: Magnesium(II) nitrate (1:2), hexahydrate
CAS REGISTRY NUMBER
: 13446-18-9
LAST UPDATED
: 199809
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: N2-O6.Mg.6H2-O
MOLECULAR WEIGHT
: 256.45
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Dusicnan horecnaty
* Magnesium dinitrate hexahydrate
* Magnesium nitrate hexahydrate
* Nitric acid, magnesium salt, hexahydrate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
MAGNESIUM OXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OM3850000
Magnesium oxide
1309-48-4
199907
32
Mg-O
40.31
MG O
Tumorigen
Human
SYNONYMS/TRADE NAMES :
* Akro-mag
* Animag
* Calcined brucite
* Calcined magnesia
* Calcined magnesite
* Granmag
* Magcal
* Magchem 100
* Maglite
* Magnesia
* Magnesia USTA
* Magnesium oxide fume
* Magnezu tlenek
* Magox
* Magox 85
* Magox 90
* Magox 95
* Magox 98
* Magox OP
* Marmag
* Oxymag
* Periclase
* Seawater magnesia
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 400 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,1745,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1120 ug/m3/24H/29D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(11),82,1984
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 480 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2209,1973
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 10 mg/m3 (fume)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,147,1971
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total particulate
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 ppm, total particulate
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 ppm, total particulate
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 15 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 10 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 6 mg/m3, JAN1999
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-GERMANY:TWA 6 mg/m3 JAN 1993
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) fume 5 mg/m3, dust 10 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 15 mg/m3 JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 6 mg/m3;STEL 12 mg/m3 JAN 1993
OEL-TURKEY:TWA 15 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3
(total dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80298
No. of Facilities: 28931 (estimated)
No. of Industries: 201
No. of Occupations: 134
No. of Employees: 354380 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80298
No. of Facilities: 42587 (estimated)
No.
No.
No.
No.
of
of
of
of
Industries: 258
Occupations: 177
Employees: 765812 (estimated)
Female Employees: 149523 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Elements by ICP, 7300
OSHA ANALYTICAL METHOD #ID-125G
MAGNESIUM PERCHLORATE
RTECS NUMBER
: SC8925000
CHEMICAL NAME
: Perchloric acid, magnesium salt
CAS REGISTRY NUMBER
: 10034-81-8
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: Cl2-O8.Mg
MOLECULAR WEIGHT
: 223.21
WISWESSER LINE NOTATION : MG G-O4*2
SYNONYMS/TRADE NAMES :
* Anhydrone
* Dehydrite
* Perchlorate de magnesium
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 14,512,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83764
No.
No.
No.
No.
of
of
of
of
Facilities: 90 (estimated)
Industries: 5
Occupations: 4
Employees: 554 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83764
No. of Facilities: 380 (estimated)
No. of Industries: 5
No. of Occupations: 3
No. of Employees: 1906 (estimated)
No. of Female Employees: 713 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MAGNESIUM SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OM4500000
Magnesium sulfate (1:1)
7487-88-9
199710
25
O4-S.Mg
120.37
MG S-O4
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Epsom salts
* Magnesium sulphate
* Sulfuric acid magnesium salt (1:1)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 428 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.11988Volume(issue)/page/year: 2,285,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 351 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Cardiac - arrhythmias (including changes in conduction)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
34,735,1996
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 80 mg/kg/2M-I
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,
Secy., P.O. Box 643, Cape Town, S. Africa) V.61932Volume(issue)/page/year: 67,145,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraspinal
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis with appropriate
anesthesia
REFERENCE :
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,
Secy., P.O. Box 643, Cape Town, S. Africa) V.61932Volume(issue)/page/year: 68,367,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NELED5 Neuroscience Letters. (Elsevier Scientific Publishers Ireland
Ltd.,
POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
117,207,1990
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1364,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1029 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and
Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i
Toksikologii,
Kiev, USSR) No.11964- Volume(issue)/page/year: 10,107,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 645 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese
Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.11980- Volume(issue)/page/year:
7,178,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,492,1962
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1364,1935
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Subcutaneous
Mammal - dog
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1364,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc.,
9650
Rockville Pike, Bethesda, MD 20814) V.11898Volume(issue)/page/year:
14,366,1905
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1364,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1750 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc.,
9650
Rockville Pike, Bethesda, MD 20814) V.11898Volume(issue)/page/year:
14,366,1905
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1800 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc.,
9650
Rockville Pike, Bethesda, MD 20814) V.11898-
Volume(issue)/page/year:
14,366,1905
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - woman
DOSE
: 320 mg/kg
SEX/DURATION
: female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 168,1170,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 750 mg/kg
SEX/DURATION
: female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.61975- Volume(issue)/page/year:
12,25,1981
** MUTATION DATA **
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 pph
REFERENCE :
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology,
Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.11947Volume(issue)/page/year: 8,45,1953
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 800 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,59,1984
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 43410
No. of Facilities: 11060 (estimated)
No. of Industries: 88
No. of Occupations: 80
No. of Employees: 106080 (estimated)
NOES - National Occupational
NOES Hazard Code - 43410
No. of Facilities: 13961
No. of Industries: 111
No. of Occupations: 95
No. of Employees: 235005
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
108074 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MAGNESIUM SULFATE HEPTAHYDRATE
RTECS NUMBER
: OM4508000
CHEMICAL NAME
: Magnesium(II), sulfate, heptahydrate
CAS REGISTRY NUMBER
: 10034-99-8
LAST UPDATED
: 199504
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: O4-S.Mg.7H2-O
MOLECULAR WEIGHT
: 246.51
COMPOUND DESCRIPTOR
: Human
SYNONYMS/TRADE NAMES :
* Sulfuric acid, magnesium salt (1:1), heptahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 183 mg/kg/4H-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
20,107,1983
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraduodenal
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 5344 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
27,129,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T1587
No. of Facilities: 2780 (estimated)
No. of Industries: 21
No. of Occupations: 10
No. of Employees: 7224 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1587
No. of Facilities: 1581 (estimated)
No. of Industries: 27
No. of Occupations: 40
No. of Employees: 27274 (estimated)
No. of Female Employees: 11373 (estimated)
MALACHITE GREEN CARBINOL
RTECS NUMBER
: DN8600000
CHEMICAL NAME
: Benzyl alcohol,
alpha,alpha-bis(p-dimethylaminophenyl)CAS REGISTRY NUMBER
: 510-13-4
BEILSTEIN REFERENCE NO. : 2222125
REFERENCE
: 4-13-00-02278 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C23-H26-N2-O
MOLECULAR WEIGHT
: 346.51
WISWESSER LINE NOTATION : 1N1&R DXQR&R DN1&1
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzenemethanol,
4-(dimethylamino)-alpha-(4-(dimethylamino)phenyl)-alpha-phenyl* Bis(p-(dimethylamino)phenyl)phenylmethanol
* Carbinolbase des malachitgruen
*
4-(Dimethylamino)-alpha-(4-(dimethylamino)phenyl)-alpha-phenyl-benzeneme
thanol
* Malachite Green carbinol
* Methanol, bis(p-(dimethylamino)phenyl)phenyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 1,5,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 1,5,1951
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MALACHITE GREEN CARBINOL HYDROCHLORIDE
RTECS NUMBER
: BQ1180000
CHEMICAL NAME
: Ammonium,
(4-(p-(dimethylamino)-alpha-phenylbenzylidene)-2,5-cy
clohexadien-1-ylidene )- dimethyl-, chloride
CAS REGISTRY NUMBER
: 569-64-2
LAST UPDATED
: 199907
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C23-H25-N2.Cl
MOLECULAR WEIGHT
: 364.95
WISWESSER LINE NOTATION : L6Y DYJ AUYR&R DN1&1& DUK1&1 &Q &G
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acryl Brilliant Green B
* ADC Malachite Green Crystals
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Aizen Malachite Green
Aizen Malachite Green Crystals
Aniline Green
Astra Malachite Green
Astra Malachite Green B
Astra Malachite Green BXX
Basic Green 4
Benzaldehyde Green
Benzal Green
Bronze Green Toner A-8002
Burma Green B
Calcozine Green V
China Green
China Green (biological stain)
C.I. 42000
C.I. Basic Green 4
Diabasic Malachite Green
Diamond Green B
Diamond Green B Extra
Diamond Green BX
Diamond Green P Extra
Fast Green
Fast Green O
Green MX
Grenoble Green
Hidaco Malachite Green Base
Hidaco Malachite Green LC
Hidaco Malachite Green SC
Light Green N
Light Green N (biological stain)
Lincoln Green Toner B 15-2900
Malachite Green
Malachite Green A
Malachite Green AN
Malachite Green B
Malachite Green chloride
Malachite Green CP
Malachite Green Crystals
Malachite Green Crystals BPC
Malachite Green hydrochloride
Malachite Green (indicator)
Malachite Green J3E
Malachite Green powder
Malachite Green WS
Malachite Lake Green A
Malachit-grun
Mitsui Malachite Green
New Victoria Green Extra I
New Victoria Green Extra II
New Victoria Green Extra O
Oji Malachite Green
Solid Green Crystals O
Solid Green O
Tertrophene Green M
Tokyo Aniline Malachite Green
Victoria Green
Victoria Green B
*
*
*
*
*
Victoria Green S
Victoria Green WB
Victoria Green WPB
Zelen malachitova
Zelen zasadita 4
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 1,5,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 1,5,1951
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 15,2445,1994
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 10 pph
REFERENCE :
BIPMAA Biopolymers. (John Wiley & Sons, Inc., 605 Third Ave., New York,
NY
10158) V.11963- Volume(issue)/page/year: 11,2537,1972
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84620
No. of Facilities: 2852 (estimated)
No. of Industries: 25
No. of Occupations: 47
No. of Employees: 28485 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84620
No. of Facilities: 5859 (estimated)
No. of Industries: 84
No. of Occupations: 65
No. of Employees: 181763 (estimated)
No. of Female Employees: 18135 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; on test (two year studies), May 1999
MALACHITE GREEN OXALATE
RTECS NUMBER
CHEMICAL NAME
: BQ1190000
: Ammonium,
(4-(p-(dimethylamino)-alpha-phenylbenzylidene)-2,5-cy
clohexadien-1-ylidene )- dimethyl-, oxalate (2:1),
oxalate (1:1)
CAS REGISTRY NUMBER
: 2437-29-8
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C46-H50-N4.C2-H2-O4.2C2-H-O4
MOLECULAR WEIGHT
: 927.10
COMPOUND DESCRIPTOR
: Agricultural Chemical
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Malachite Green Oxalate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rabbit
76 mg/kg
REACTION SEVERITY
: Severe
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
56,43,1984
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 275 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
56,43,1984
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
56,43,1984
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
56,43,1984
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 40 ug/plate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
56,43,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2442
No. of Facilities: 6 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 112 (estimated)
No. of Female Employees: 41 (estimated)
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MALEIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OM9625000
Maleic acid
110-16-7
0605762
4-02-00-02199 (Beilstein Handbook Reference)
199710
13
C4-H4-O4
116.08
QV1U1VQ -C
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Butenedioic acid, (Z)* cis-Butenedioic acid
* cis-1,2-Ethylenedicarboxylic acid
* 1,2-Ethylenedicarboxylic acid, (Z)
* Kyselina maleinova
* Maleinic acid
* Malenic acid
* Toxilic acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 7-4/1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 7-4/1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%/2M
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 33,387,1950
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 708 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 7-4/1970
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >720 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 7-4/1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
34,1196,1940
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1560 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 7-4/1970
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
183,89,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84505
No. of Facilities: 1840 (estimated)
No. of Industries: 22
No. of Occupations: 27
No. of Employees: 17036 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84505
No. of Facilities: 2076 (estimated)
No. of Industries: 36
No. of Occupations: 45
No. of Employees: 30064 (estimated)
No. of Female Employees: 11590 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MALEIC ACID DISODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
:
:
:
:
:
:
ON2000000
Maleic acid, disodium salt
371-47-1
199707
3
C4-H2-O4.2Na
MOLECULAR WEIGHT
: 160.04
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 2-Butenedioic acid (Z)-, disodium salt
* Disodium maleate
* Maleinan sodny
* Sodium dimaleate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,314,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,314,1986
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MALEIC ANHYDRIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
ON3675000
Maleic anhydride
108-31-6
0106909
5-17-11-00055 (Beilstein Handbook Reference)
199907
46
C4-H2-O3
98.06
T5VOVJ
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Anhydrid kyseliny maleinove
* cis-Butenedioic anhydride
* 2,5-Furandione
* Maleic acid anhydride
* Maleic anhydride
* Maleinanhydrid
* Toxilic anhydride
* RCRA waste number U147
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 97 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,79,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
465 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(4),42,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 875 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,79,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,417,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,79,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9800 ug/m3/6H/26W-I
TOXIC EFFECTS :
Blood - changes in spleen
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 10,517,1988
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1220 mg/kg/61W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
17,100,1963
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4060 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 7,359,1986
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 230 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 111971- Volume(issue)/page/year:
27,95,1981
*** REVIEWS ***
ACGIH TLV-TWA 1.0 mg/m3 (0.25 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,250,1970
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.25 ppm (1 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,148,1971
OSHA PEL (Gen Indu):8H TWA 0.25 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.25 ppm
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.25 ppm
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 0.25 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.25 ppm (1 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.1 ppm (0.4 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.25 ppm (1 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.2 ppm (0.8 mg/m3), JAN1999
OEL-FINLAND:TWA 0.25 ppm (1 mg/m3);STEL 0.75 ppm (3 mg/m3);Skin JAN 1993
OEL-FRANCE: VLE 1 mg/m3, JAN1999
OEL-GERMANY:TWA 0.2 ppm (0.8 mg/m3) JAN 1993
OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.25 ppm (1 mg/m3) JAN 1993
OEL-POLAND: TWA 0.5 mg/m3, STEL 1.0 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 0.25 ppm (1 mg/m3) JAN 1993
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.3 ppm (1.2 mg/m3);STEL 0.6 ppm (2.5 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.2 ppm (0.8 mg/m3);STEL 0.4 ppm (1.6 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.25 ppm (1 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MALEIC ANHYDRIDE-air:10H TWA 0.25 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 43660
No. of Facilities: 5310 (estimated)
No. of Industries: 51
No. of Occupations: 69
No. of Employees: 71386 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 43660
No. of Facilities: 5924 (estimated)
No. of Industries: 65
No. of Occupations: 69
No. of Employees: 81551 (estimated)
No. of Female Employees: 14807 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Maleic anhydride, 3512
OSHA ANALYTICAL METHOD #25
MALEIMIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Maleic imide
* Maleinimide
* Pyrrole-2,5-dione
* 1H-Pyrrole-2,5-dione
ON4800000
Maleimide
541-59-3
0106910
5-21-10-00003 (Beilstein Handbook Reference)
199710
7
C4-H3-N-O2
97.08
T5VMVJ
Reproductive Effector
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(11),109,1975
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7766 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
37,15,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - hemorrhage
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - other changes
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
27,151,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 750 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
37,15,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3100 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
37,15,1976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MALONIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OO0175000
Malonic acid
141-82-2
1751370
4-02-00-01874 (Beilstein Handbook Reference)
199701
11
C3-H4-O4
104.07
QV1VQ
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Carboxyacetic acid
* Dicarboxymethane
* Kyselina malonova
* Methanedicarboxylic acid
* Propanedioic acid
* USAF EK-695
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 22-3/1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 22-3/1971
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1310 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 22-3/1971
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >8900 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 22-3/1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4937,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
34,1196,1940
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 22-3/1971
** MUTATION DATA **
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10080 mg/kg/6W
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 9,387,1988
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4746
No. of Facilities: 46 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 1913 (estimated)
No. of Female Employees: 272 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MALONONITRILE
RTECS NUMBER
: OO3150000
CHEMICAL NAME
: Malononitrile
CAS REGISTRY NUMBER
: 109-77-3
BEILSTEIN REFERENCE NO. : 0773697
REFERENCE
: 4-02-00-01892 (Beilstein Handbook Reference)
LAST UPDATED
: 199812
DATA ITEMS CITED
: 22
MOLECULAR FORMULA
: C3-H2-N2
MOLECULAR WEIGHT
: 66.07
WISWESSER LINE NOTATION : NC1CN
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Cyanoacetonitrile
* Dicyanomethane
* Dwumetylosulfotlenku
* Malonic acid dinitrile
* Malonic dinitrile
* Methane, dicyano* Methylene cyanide
* Nitril kyseliny malonove
* Propanedinitrite
* RCRA waste number U149
* USAF A-4600
* USAF KF-19
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,899,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
15,553,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 27,1,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20550 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 27,1,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 31500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 27,1,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
9,50,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 228,1315,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 3,77,1897
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#07576
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Subcutaneous
V.4-
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 6500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - nausea or vomiting
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 3,77,1897
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10043 ug/kg
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 3,64,1983
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 96,202,1927
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB
1001,
00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information,
see
PJPAE3 Volume(issue)/page/year: 31,563,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 21 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 27,1,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 3,77,1897
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 95 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 3,77,1897
V.4-
V.4-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28500 mg/kg/19W-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
15,553,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MALONONITRILE-air:10H TWA 3 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5636
No. of Facilities: 4 (estimated)
No. of Industries: 1
No. of Occupations: 15
No. of Employees: 1233 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MALTOSE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OO5250000
Maltose
69-79-4
0093798
5-17-07-00189 (Beilstein Handbook Reference)
199701
23
C12-H22-O11
342.34
T6OTJ B1Q CQ DQ EQ F- 2O -D
Tumorigen
Drug
Reproductive Effector
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Cextromaltose
* 4-(alpha-D-Glucopyranosido)-alpha-glucopyranose
* D-Glucose, 4-O-alpha-D-glucopyranosyl* 4-(alpha-D-Glucosido)-D-glucose
* Maltobiose
* D-Maltose
* Malt sugar
* alpha-Malt sugar
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 100 mg/kg/2D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
118,526,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 34800 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 7,53,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30600 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,251,1972
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >26700 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,251,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15300 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,251,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >44 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1139,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 29100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1139,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 38600 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 7,53,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 26800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 7,53,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 25200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,541,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mL/kg/30D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,251,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 780 gm/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,1175,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 780 gm/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,1441,1972
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1750 mg/kg/50W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
48,556,1957
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 15 gm/kg
SEX/DURATION
: female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,751,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 gm/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
6,361,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 30 gm/kg
SEX/DURATION
: female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,751,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 60 gm/kg
SEX/DURATION
: female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,751,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 22500 mg/kg
SEX/DURATION
: female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 7,1359,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rabbit
105 mg/kg
female 18-31 day(s) after conception
lactating female 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 16,971,1978
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83248
No. of Facilities: 179 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 1441 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83248
No. of Facilities: 716 (estimated)
No. of Industries: 7
No. of Occupations: 10
No. of Employees: 11967 (estimated)
No. of Female Employees: 8150 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MANDELIC ACID
RTECS NUMBER
: OO6300000
CHEMICAL NAME
: Mandelic acid
CAS REGISTRY NUMBER
: 90-64-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C8-H8-O3
MOLECULAR WEIGHT
: 152.16
WISWESSER LINE NOTATION : QYR&VQ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acido mandelico
* Amygdalic acid
* Glycolic acid, phenyl-
*
*
*
*
*
*
*
*
*
*
alpha-Hydroxyphenylacetic acid
alpha-Hydroxy-alpha-toluic acid
Kyselina 2-fenyl-2-hydroxyethanova
Kyselina mandlova
Paramandelic acid
Phenylglycolic acid
Phenylhydroxyacetic acid
Racemic mandelic acid
alpha-Toluic acid, alpha-hydroxyUromaline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 64,79,1940
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29,
1943-71.
Suspended. Volume(issue)/page/year: 4,223,1946
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
V.4-
Gastrointestinal - ulceration or bleeding from stomach
Liver - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 64,79,1940
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84432
No. of Facilities: 174 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1744 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MANGANESE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OO9275000
Manganese
7439-96-5
199907
54
Mn
54.94
MN
Tumorigen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Colloidal manganese
* Magnacat
* Mangan
* Manganese
* Mangan nitridovany
* Tronamang
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/24H
Mild
V.4-
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2300 ug/m3
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
27,454,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 180 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
7,217,1981
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
*** REVIEWS ***
ACGIH TLV-TWA 0.2(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX)
V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975
TOXICOLOGY REVIEW
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.11971- Volume(issue)/page/year:
4,487,1974
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control.
(Kogai
Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka,
Minato-ku,
Tokyo 107, Japan) V.11965- Volume(issue)/page/year: 11,1300,1975
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Mn,1,1973
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
IMSUAI Industrial Medicine and Surgery.
1949-73.
For publisher information, see IOHSA5.
24,1,1955
(Northbrook, IL)
V.18-42,
Volume(issue)/page/year:
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:air-CL 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 5 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 5 mg/m3, JAN1999
OEL-AUSTRALIA:TWA 1 mg/m3;STEL 3 mg/m3 (fume) JAN 1993
OEL-BELGIUM:TWA 1 mg/m3;STEL 3 mg/m3 (fume) JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 1 mg/m3 (fume) JAN 1993
OEL-JAPAN: OEL 0.3 mg/m3, resp. dust, JAN1999
OEL-FINLAND:TWA 2.5 mg/m3 JAN 1993
OEL-GERMANY:TWA 5 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg/m3, MAC(C) 5 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993
OEL-SWEDEN: NGV 1 mg/m3, TGV 2.5 mg/m3 (resp. dust), JAN1999
OEL-RUSSIA:STEL 0.2 mg/m3 (fume) JAN 1993
OEL-SWEDEN:TWA 2.5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1 mg/m3 (fume) JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
OEL-THAILAND:TWA 5 mg/m3 JAN 1993
OEL-TURKEY:TWA 5 mg/m3 (fume) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 3 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MANGANESE COMPDS (as Mn)-air:TWA 1 mg/m3;STEL 3 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44000
No. of Facilities: 1963 (estimated)
No. of Industries: 29
No. of Occupations: 53
No. of Employees: 19787 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5920
No. of Facilities: 26 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 305 (estimated)
No. of Female Employees: 71 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5992
No.
No.
No.
No.
No.
of
of
of
of
of
Facilities: 235 (estimated)
Industries: 9
Occupations: 9
Employees: 4560 (estimated)
Female Employees: 12 (estimated)
NOES - National Occupational
NOES Hazard Code - 44000
No. of Facilities: 66404
No. of Industries: 316
No. of Occupations: 125
No. of Employees: 756403
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
15912 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID-125G
MANGANESE (II) NITRATE
RTECS NUMBER
: QU9780000
CHEMICAL NAME
: Nitric acid, manganese(2+) salt
CAS REGISTRY NUMBER
: 10377-66-9
LAST UPDATED
: 199907
DATA ITEMS CITED
: 25
MOLECULAR FORMULA
: N2-O6.Mn
MOLECULAR WEIGHT
: 178.96
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Manganese dinitrate
* Manganese (II) nitrate
* Manganese(2+) nitrate
* Manganese (II) nitrate, anhydrous
* Manganous dinitrate
* Manganous nitrate
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
31,185,1975
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:CL 5 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993
OEL-JAPAN: OEL 0.3 mg(Mn)/m3, resp. dust, JAN1999
OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3
(resp. dust) JAN 1993
OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3
(total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81886
No. of Facilities: 41 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 841 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81886
No. of Facilities: 612 (estimated)
No. of Industries: 10
No. of Occupations: 17
No. of Employees: 7066 (estimated)
No. of Female Employees: 1070 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MANGANESE CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
:
:
:
:
:
OO9625000
Manganese(II) chloride (1:2)
7773-01-5
199907
88
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE
* Manganese
* Manganese
* Manganous
: Cl2-Mn
: 125.84
: MN G2
: Tumorigen
Mutagen
Reproductive Effector
NAMES :
chloride
dichloride
chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 26(12),8,1961
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 147 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.11968(?)Volume(issue)/page/year: 23,153,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 92600 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.11968(?)Volume(issue)/page/year: 23,153,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 38,221,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1031 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(9),15,1971
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 121 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 244,17,1962
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 38 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
ACRAE3 Acta Radiologica. (Acta Radiologica, POB 7449, S10391 Stockholm,
Sweden) V.281987- Volume(issue)/page/year: 38,770,1997
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intramuscular
Rodent - mouse
255 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 38,221,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 202 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 128 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Vascular - BP lowering not characterized in autonomic section
Gastrointestinal - other changes
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 102,262,1929
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 102,262,1929
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 102,262,1929
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Subcutaneous
Rodent - rabbit
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 64800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Vascular - BP lowering not characterized in autonomic section
Gastrointestinal - other changes
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 102,262,1929
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 102,262,1929
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 916 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(9),15,1971
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Subcutaneous
(V/O
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 102,262,1929
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg/17W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
17,21,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1240 mg/kg/7D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Effect on specific coenzyme - not otherwise specified
Biochemical - Neurotransmitters or modulators (putative) - dopamine in
striatum
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
68,566,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2520 mg/kg/3W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Vascular - BP lowering not characterized in autonomic section
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 4,701,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2405 mg/kg/30D-C
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O
Me
zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955Volume(issue)/page/year: 37(1),39,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 245 gm/kg/35W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80.
For
publisher information, see NTOTDY. Volume(issue)/page/year: 2,37,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 630 mg/kg/6W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 34,242,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 271 gm/kg/1Y-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 57,34,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 280 mg/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 22,91,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6 gm/kg/60D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 26(12),8,1961
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 mg/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
33,449,1973
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2080 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 23,393,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2080 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 23,393,1964
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 106 mg/kg
SEX/DURATION
: female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(11),80,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 148 gm/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,1,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
72420 mg/kg
female 1-22 day(s) after conception
lactating female 30 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523)
Volume(issue)/page/year:
19,17,1997
V.9-
1987-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 9060 ug/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ACRDA8 Acta Radiologica: Diagnosis. (Box 7449, S-10391 Stockholm,
Sweden)
New series: V.11963- Volume(issue)/page/year: 38,759,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 45302 ug/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ACRDA8 Acta Radiologica: Diagnosis. (Box 7449, S-10391 Stockholm,
Sweden)
New series: V.11963- Volume(issue)/page/year: 38,759,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10067 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10067 ug/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - pig
DOSE
: 4581 mg/kg
SEX/DURATION
: female 12-16 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.301969- Volume(issue)/page/year: 33,2872,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 30 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 40,597,1988
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
126,9,1984
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1600 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,59,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.131,185,1975
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 24000 ppm
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 6,45,1958
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 15,587,1977
1963-
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 4 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
198,513,1977
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,133,1994
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 4 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 126,357,1973
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
193,237,1988
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA damage
: Human Lymphocyte
: 1500 umol/tube
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,295,1991
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10640 ug/kg/30W (Continuous)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(11),80,1984
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 106 mg/kg/30W (Continuous)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(11),80,1984
(V/O
(V/O
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 2 mmol/L
REFERENCE :
AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama,
Japan)
V.27
1973- Volume(issue)/page/year: 33,141,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Mammary gland
DOSE/DURATION
: 1 mmol/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
67,221,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 40 mg/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 9,367,1982
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 130 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,193,1979
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in mammalian somatic cells
: Rodent - hamster Lung
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
68,259,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 5 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
198,513,1977
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-73-125,1973
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Mn,121,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:CL 5 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993
OEL-JAPAN: OEL 0.3 mg(Mn)/m3, resp. dust, JAN1999
OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3
(resp. dust) JAN 1993
OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3
(total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84353
No. of Facilities: 320 (estimated)
No. of Industries: 7
No. of Occupations: 12
No. of Employees: 4916 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84353
No. of Facilities: 788 (estimated)
No. of Industries: 6
No. of Occupations: 16
No. of Employees: 13961 (estimated)
No. of Female Employees: 9451 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis
rec
assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MANGANESE CHLORIDE TETRAHYDRATE
RTECS NUMBER
: OO9650000
CHEMICAL NAME
: Manganese(II) chloride, tetrahydrate
CAS REGISTRY NUMBER
: 13446-34-9
LAST UPDATED
: 199907
DATA ITEMS CITED
: 45
MOLECULAR FORMULA
: Cl2-Mn.4H2-O
MOLECULAR WEIGHT
: 197.92
WISWESSER LINE NOTATION : MN G2 &QH 4
COMPOUND DESCRIPTOR
: Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Manganese chloride tetrahydrate
* Manganese dichloride tetrahydrate
* Manganous chloride tetrahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1484 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 10,95,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 138 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402)
Volume(issue)/page/year: 10,95,1975
No.1-
1972-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JINCAO Journal of Inorganic and Nuclear Chemistry. (Oxford, UK) V.1-43,
1955-81. Volume(issue)/page/year: 41,1507,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 144 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,461,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
69,45,1993
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 378 mg/kg/30D-I
TOXIC EFFECTS :
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in iron
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 11,515,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
225 mg/kg/15D-I
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - monoamine oxidase
REFERENCE :
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,
Elmsford, NY 10523) V.11972- Volume(issue)/page/year: 6,147,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 324 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
61,227,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 540 mg/kg/90D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 32,212,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 384 mg/kg/24W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral
nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 62,148,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 64 mg/kg/4D-I
TOXIC EFFECTS :
Cardiac - pulse rate
Liver - hepatitis (hepatocellular necrosis), diffuse
Related to Chronic Data - death
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 25,344,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 10940 mg/kg/78W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Neurotransmitters or modulators (putative) - catecholamine
levels in CNS
Biochemical - Neurotransmitters or modulators (putative) - dopamine in
striatum
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
4,189,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 9360 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 24,82,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 156 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 24,75,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 265 mg/kg/3W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
IRGGAJ Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene.
(Heidelberg, Fed. Rep. Ger.) V.19-25, 1962-69. For publisher
information,
see IAEHDW. Volume(issue)/page/year: 21,107,1964/1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - amino acids (including renal
excretion)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
3,249,1979
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 141 gm/kg
SEX/DURATION
: female 90 day(s) pre-mating - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,377,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 47280 ug/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 52,109,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 239 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JINCAO Journal of Inorganic and Nuclear Chemistry.
1955-81. Volume(issue)/page/year: 41,1507,1979
(Oxford, UK)
V.1-43,
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 13,300,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 80 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
69,45,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary
and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.191977- Volume(issue)/page/year: 38,7,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 105 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,534,1975
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:CL 5 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993
OEL-JAPAN: OEL 0.3 mg(Mn)/m3, resp. dust, JAN1999
OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3
(resp. dust) JAN 1993
OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3
(total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4985
No. of Facilities: 110 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 3297 (estimated)
No. of Female Employees: 1033 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
MANGANESE DIOXIDE
RTECS NUMBER
: OP0350000
CHEMICAL NAME
: Manganese dioxide
CAS REGISTRY NUMBER
: 1313-13-9
LAST UPDATED
: 199907
DATA ITEMS CITED
: 34
MOLECULAR FORMULA
: Mn-O2
MOLECULAR WEIGHT
: 86.94
WISWESSER LINE NOTATION : MN O2
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Black manganese oxide
* BOG manganese
* Braunstein
* Bruinsteen
* Cement Black
* C.I. 77728
* C.I. Pigment Black 14
* C.I. Pigment Brown 8
* Mangaanbioxyde
*
*
*
*
*
*
*
*
*
*
*
*
Mangaandioxyde
Mangandioxid
Manganese binoxide
Manganese (biossido di)
Manganese (bioxyd de)
Manganese Black
Manganese (diossido di)
Manganese (dioxyde de)
Manganese(IV) oxide
Manganese peroxide
Manganese superoxide
Pyrolusite Brown
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >3478 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 10,95,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 20(1),25,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 422 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I.
Mendeleeva.
Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.51960Volume(issue)/page/year: 19,186,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Intravenous
Rodent - rabbit
45 mg/kg
(V/O
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,899,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1800 ug/m3/24H/35D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(12),53,1984
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
49 mg/m3/7H
female 75 day(s) pre-mating
female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 39,623,1980
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-73-125,1973
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Mn,1,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:CL 5 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993
OEL-JAPAN: OEL 0.3 mg(Mn)/m3, resp. dust, JAN1999
OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3
(resp. dust) JAN 1993
OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3
(total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 (fume and respirable dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44030
No. of Facilities: 3820 (estimated)
No. of Industries: 48
No. of Occupations: 60
No. of Employees: 53685 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 44030
No. of Facilities: 3347 (estimated)
No. of Industries: 41
No. of Occupations: 50
No. of Employees: 71963 (estimated)
No. of Female Employees: 15526 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MANGANESE SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
OP0893500
Manganese, monosulfate, monohydrate
10034-96-5
199907
34
O4-S.Mn.H2-O
169.02
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Manganese sulfate monohydrate
* Manganese(2+) sulfate monohydrate
* Manganous sulfate monohydrate
* Sulfuric acid, manganese(2+) salt (1:1), monohydrate
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/14D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in other cell count (unspecified)
Blood - changes in leukocyte (WBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-428,1993
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28437 mg/kg/13W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-428,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 546 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cells
Blood - other changes
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-428,1993
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1314 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
(Research
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-428,1993
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 513 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
240,159,1990
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
137,47,1984
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
137,47,1984
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 205 mg/kg/24H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
240,159,1990
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 718 mg/kg/7D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
240,159,1990
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 513 mg/kg/5D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
240,159,1990
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 180 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993
OEL-JAPAN: OEL 0.3 mg(Mn)/m3, resp. dust, JAN1999
OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3
(resp. dust) JAN 1993
OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3
(total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1601
No. of Facilities: 60 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 893 (estimated)
No. of Female Employees: 398 (estimated)
*** STATUS IN U.S. ***
NTP Carcinogenesis studies (feed);equivocal evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-428,1993
NTP Carcinogenesis studies (feed);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-428,1993
(Research
(Research
MANGANESE(II) ACETATE
RTECS NUMBER
: AI5770000
CHEMICAL NAME
: Acetic acid, manganese(II) salt (2:1)
CAS REGISTRY NUMBER
: 638-38-0
LAST UPDATED
: 199907
DATA ITEMS CITED
: 24
MOLECULAR FORMULA
: C4-H6-O4.Mn
MOLECULAR WEIGHT
: 173.04
WISWESSER LINE NOTATION : OV1 2 &-MNCOMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Diacetylmanganese
* Manganese acetate
* Manganese(2+) acetate
* Manganese(II) acetate
* Manganese diacetate
* Manganous acetate
* Octan manganaty
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice,
Czechoslavakia, Mar. 29, 1977 Volume(issue)/page/year: 29MAR1977
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
31,185,1975
*** REVIEWS ***
ACGIH TLV-TWA 0.2 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:CL 5 mg(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993
OEL-DENMARK: TWA 2.5 mg(Mn)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993
OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993
OEL-JAPAN: OEL 0.3 mg(Mn)/m3, resp. dust, JAN1999
OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3
(resp. dust) JAN 1993
OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3
(total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84621
No. of Facilities: 88 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 1178 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84621
No. of Facilities: 33 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 1283 (estimated)
No. of Female Employees: 241 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MANNITOL (D-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OP2060000
Mannitol, D69-65-8
1721898
4-01-00-02841 (Beilstein Handbook Reference)
199904
12
C6-H14-O6
182.20
Q1YQYQ 2 -BBAA -D
Tumorigen
Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* 1,2,3,4,5,6-Hexanehexol
* Manna sugar
* Mannite
* D-Mannitol
* NCI-C50362
* Osmitrol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intravenous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 17143 mg/kg/2D-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St.,
Chicago,
IL 60610) V.11908- Volume(issue)/page/year: 144,2053,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 32,1367,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9690 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 32,1367,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 22 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 40,160,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 35,98,1936
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 32,1367,1981
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94,
1930-73. For publisher information, see AMICCW.
Volume(issue)/page/year:
91,305,1973
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 50 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 79,1171,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4308
No. of Facilities: 1555 (estimated)
No. of Industries: 14
No. of Occupations: 31
No. of Employees: 41268 (estimated)
No. of Female Employees: 28689 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-236,1982
(Research
MEBENDAZOLE
RTECS NUMBER
CHEMICAL NAME
: EY8600000
: Carbamic acid, N-(5-benzoylbenzimidazol-2-yl)-,
methyl ester
CAS REGISTRY NUMBER
: 31431-39-7
LAST UPDATED
: 199606
DATA ITEMS CITED
: 25
MOLECULAR FORMULA
: C16-H13-N3-O3
MOLECULAR WEIGHT
: 295.32
WISWESSER LINE NOTATION : T56 BM DNJ CMVO1 GVR
COMPOUND DESCRIPTOR
: Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bantenol
* 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester
* N-2 (5-Benzoyl-benzimidazole) carbamate de methyle
* 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester
* N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle
* (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester
* Besantin
* Lomper
* MBDZ
* Mebendazole
* Mebenvet
* Methyl 5-benzoyl benzimidazole-2-carbamate
* Methyl 5-benzoyl-2-benzimidazolecarbamate
* Noverme
* Ovitelmin
* Pantelmin
* R 17635
* Telmin
* Vermicidin
* Vermirax
* Vermox
* Verpanyl
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 714 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 19,735,1988
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intramuscular
Rodent - rat
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1207,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical
Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11932- Volume(issue)/page/year: 47(6),48,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 712 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical
Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11932- Volume(issue)/page/year: 48(4),29,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1207,1990
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1207,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: >640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,371,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,371,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >1280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,371,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: >40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3657267
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - domestic
DOSE/DURATION
: >80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3657267
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3640 mg/kg/13W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - changes in liver weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,371,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 78400 ug/kg
SEX/DURATION
: female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 78400 ug/kg
SEX/DURATION
: female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 78400 ug/kg
SEX/DURATION
: female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 76,147,1974
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 600 nmol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,4478,1978
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 10 mg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,185,1995
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 270 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
26,292,1995
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,67,1980
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 2 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,4478,1978
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research.
Inc.,
41 E. 11th St., New York, NY 10003) V.11975Volume(issue)/page/year:
340E,225,1990
*** REVIEWS ***
(Alan R. Liss,
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
32,151,1975
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Host-mediated assay
MECHLORETHAMINE HYDROCHLORIDE
RTECS NUMBER
: IA2100000
CHEMICAL NAME
: Diethylamine, 2,2'-dichloro-N-methyl,
hydrochloride
CAS REGISTRY NUMBER
: 55-86-7
LAST UPDATED
: 199809
DATA ITEMS CITED
: 79
MOLECULAR FORMULA
: C5-H11-Cl2-N.Cl-H
MOLECULAR WEIGHT
: 192.53
WISWESSER LINE NOTATION : G2N1&2G &GH
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Antimit
* Azotoyperite
* N,N-Bis(2-chloraethyl)methylamin-hydrochlorid
* Bis(2-chloroethyl)methylamine hydrochloride
* N,N-Bis(2-chloroethyl)methylamine hydrochloride
* C 6866
* Caryolysine
* Chloramin
* Chlormethine hydrochloride
* Chlormethinum
* 2-Chloro-N-(2-chloroethyl)-N-methylethanamine hydrochlroide
* Dichloren
* beta,beta'-Dichlorodiethyl-N-methylamine hydrochloride
* Di(2-chloroethyl)methylamine hydrochloride
* 1,5-Dichloro-3-methyl-3-azapentane hydrochloride
* 2,2'-Dichloro-N-methyldiethylamine hydrochloride
* Dimitan
* Embichin
* Erasol
* Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, hydrochloride
* HN2 hydrochloride
* N-Lost
* Kloramin
* MBA hydrochloride
* Mechlorethamine hydrochloride
* N-Methyl-bis-beta-chlorethylamine hydrochloride
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
N-Methylbis(2-chloroethyl)amine hydrochloride
N-Methyl-2,2'-dichlorodiethylamine hydrochloride
N-Methyl-di-2-chloroethylamine hydrochloride
Methyldi(beta-chloroethyl)amine hydrochloride
Methyldi(2-chloroethyl)amine hydrochloride
Mustargen hydrochloride
Mustine hydrochloride
NCI-C56382
Nitrogen mustard hydrochloride
Nitrogranulogen
N-Mustard
NSC-762 hydrochloride
Pliva
Stickstofflost
Zagreb
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human
DOSE/DURATION
: 400 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - leukopenia
Blood - thrombocytopenia
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1Volume(issue)/page/year: 6,50,1965
(C.V. Mosby
1960-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,735,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW
12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.3051972Volume(issue)/page/year: 306,64,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965Volume(issue)/page/year: 52,76,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
62,96,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2750 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW
12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.3051972Volume(issue)/page/year: 306,64,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Mammal - dog
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 340 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - leukopenia
Blood - other changes
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC)
1964-75. For publisher information, see CTRRDO.
Volume(issue)/page/year:
2,201,1965
1909/10-
V.1-5,
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 3850 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 95,131,1949
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 12500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB158-507
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg/10D-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
2,50,1961
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg/4W
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
36,915,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 22 mg/kg/21W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
3,118,1949
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 mg/kg/6D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
11,415,1950
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
14,131,1953
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
1130 mg/kg
male 8 week(s) pre-mating
female 2 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,43A,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 700 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 23,231,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 750 ug/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin,
Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 117,467,1951
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
1600 ug/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,141,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1600 ug/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,141,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 2,1075,1949
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2500 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
AMUK** Acta Medica University Kioto. (Kioto, Japan)
Volume(issue)/page/year: 36,20,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
2500 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ASMUAA Acta Scholae Medicinalis Universitatis in Kioto. (Kyoto, Japan)
V.27-40, 1947-70. Discontinued. Volume(issue)/page/year: 36,20,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 1 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 1 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 500 ug/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 2 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 13,151,1976
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 66 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19(Suppl 21),2,1992
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 8 ug/plate
REFERENCE :
AJHPA9 American Journal of Hospital Pharmacy. (American Soc. of Hospital
Pharmacists, 4630 Montgomery Ave., Bethesda, MD 20814) V.151958Volume(issue)/page/year: 43,344,1986
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 ug/disc
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 6,23,1958
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 200 mg/L
REFERENCE :
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.)
1930-73. For publisher information, see AMICCW.
Volume(issue)/page/year:
51,9,1965
V.1-94,
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
38,271,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
521,484,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
521,484,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.41959- Volume(issue)/page/year:
15,275,1970
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
95,237,1982
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
95,237,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,241,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 2500 umol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5.
Corp.,
(Plenum Pub.
233 Spring St., New York, NY 10013)
Volume(issue)/page/year:
6,220,1970
V.2-
1966-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 21 mmol/L
REFERENCE :
ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin,
Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued.
Volume(issue)/page/year: -,193,1962
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 8 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 103,175,1976
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,117,1974
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
92,427,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 10 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
26,2437,1966
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 50 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1637,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 6250 ng/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK)
Volume(issue)/page/year: 5,1637,1984
V.1-
1980-
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Mammary gland
DOSE/DURATION
: 1 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
35,1171,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 30 umol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 500 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1697,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Mammary gland
DOSE/DURATION
: 250 nmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
35,1171,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 200 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1697,1987
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 98250 ng/kg
REFERENCE :
YFZADL Yaowu Fenxi Zazhi. Journal of Pharmaceutical Analysis. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.11981- Volume(issue)/page/year: 11,30,1991
TYPE OF TEST
ROUTE OF EXPOSURE
: Micronucleus test
: Subcutaneous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1563 ug/kg
REFERENCE :
YFZADL Yaowu Fenxi Zazhi. Journal of Pharmaceutical Analysis. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.11981- Volume(issue)/page/year: 11,30,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 25 umol/L
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 92,1692,1981
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
29,994,1969
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
43,231,1977
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 20 ug/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
23,115,1985
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 3 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
8,1,1974
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Heritable translocation test
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 2400 ug/kg
REFERENCE :
JOGNAU Journal of Genetics. (Belghoria, India) V.1-63, 1910-77.
Discontinued. Volume(issue)/page/year: 51,81,1952
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 120 umol/L
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 92,943,1981
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 9,193,1975
IARC Cancer Review:Human Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,269,1987
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,269,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4355
No. of Facilities: 162 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 4618 (estimated)
No. of Female Employees: 2398 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion;
Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
MELAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OS0700000
Melamine
108-78-1
0124341
4-26-00-01253 (Beilstein Handbook Reference)
199904
30
C3-H6-N6
126.15
T6N CN ENJ BZ DZ FZ
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aero
* Cyanuramide
* Cyanuric triamide
* Cyanurotriamide
* Cyanurotriamine
* DG 002 (amine)
* Hicophor PR
* Isomelamine
* NCI-C50715
* Pluragard
* Pluragard C 133
* Teoharn
* Theoharn
* 2,4,6-Triamino-s-triazine
* 2,4,6-Triamino-1,3,5-triazine
* 1,3,5-Triazine-2,4,6-triamine
* s-Triazine, 2,4,6-triamino* Virset 656-4
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration into the eye
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,153,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3161 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
72,292,1984
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3248 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(2),14,1993
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2769,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(2),14,1993
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3296 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
72,292,1984
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2769,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(2),14,1993
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,110,1990
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
32760 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-245,1983
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 58 ug/m3/17W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(2),14,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 93600 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-245,1983
(Research
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 195 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
72,292,1984
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 197 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
(Research
NTP-TR-245,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 162 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
72,292,1984
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 ug/m3
SEX/DURATION
: male 17 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(2),14,1993
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 78 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,342,1982
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,333,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,333,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
ECIET* European Chemical Industry Ecology and Toxicology Centre. Joint
Assessment of Commodity Chemicals. (Avenue Louise 250, B-63, B-1050
Brussels, Belgium) Volume(issue)/page/year: (1),-,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81887
No. of Facilities: 1043 (estimated)
No. of Industries: 32
No. of Occupations: 49
No. of Employees: 31892 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81887
No. of Facilities: 2132 (estimated)
No. of Industries: 27
No. of Occupations: 44
No. of Employees: 43104 (estimated)
No. of Female Employees: 6239 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Bioassay (feed);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-245,1983
NTP Carcinogenesis Bioassay (feed);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
(Research
(Research
Triangle Park, NC 27709) No.206NTP-TR-245,1983
MELATONIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
Volume(issue)/page/year:
AC5955000
Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)73-31-4
0205542
5-22-12-00042 (Beilstein Handbook Reference)
199907
47
C13-H16-N2-O2
232.31
T56 BMJ D2MV1 GO1
Tumorigen
Drug
Mutagen
Reproductive Effector
Hormone
SYNONYMS/TRADE NAMES :
* Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)* N-Acetyl-5-methoxytryptamine
* Melatonin
* Melatonine
* 5-Methoxy-N-acetyltryptamine
* N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 227,587,1983
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 227,587,1983
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 227,587,1983
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 356 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 227,587,1983
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 227,587,1983
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1375 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 17,559,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
No.1-
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 227,587,1983
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02739
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15 mg/kg/2W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 34,19758,1996
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4200 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
GETRE8 Gematologiya i Transfuziologiya. Hematology and Transfusion
Science.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.281983Volume(issue)/page/year: 28(2),47,1983
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
27 mg/kg
1963-
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 22,63,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2800 ug/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
75,238,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 140 ug/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
141,277,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)
V.11970- Volume(issue)/page/year: 4,385,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 900 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
31(Suppl),68,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1400 ug/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
75,238,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 140 ug/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.11877Volume(issue)/page/year: 117,228,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 80 ug/kg
SEX/DURATION
: male 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
33,618,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland) V.11965/66- Volume(issue)/page/year: 12,354,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland) V.11965/66- Volume(issue)/page/year: 12,354,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Ocular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 375 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland) V.11965/66- Volume(issue)/page/year: 12,354,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Ocular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland) V.11965/66- Volume(issue)/page/year: 12,354,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 36 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 21,363,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 mg/kg
SEX/DURATION
: female 19 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044)
Volume(issue)/page/year:
21,65,1976
V.1-
1955-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 560 mg/kg
SEX/DURATION
: female 70 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
JPRSE9 Journal of Pineal Research. (Munksgaard International Publishers,
POB 2148, DK-1016, Copenhagen K, Denmark) V.11984Volume(issue)/page/year: 13,13,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 14 mg/kg
SEX/DURATION
: male 70 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
23,1069,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 70 mg/kg
SEX/DURATION
: male 70 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
23,1069,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5600 ug/kg
SEX/DURATION
: female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
75,238,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 7500 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
83,599,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 12 mg/kg
SEX/DURATION
: male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Reproductive - Paternal Effects - other effects on male
REFERENCE :
HRMRA3 Hormone Research. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.41978- Volume(issue)/page/year: 15,99,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 1260 ug/kg
SEX/DURATION
: female 9 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 78,381,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 9800 ug/kg
SEX/DURATION
: female 49 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland) V.11965/66- Volume(issue)/page/year: 33,112,1981
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 7 mg/kg
SEX/DURATION
: male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
22,277,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 21 mg/kg
SEX/DURATION
: male 15 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 175,254,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 14 mg/kg
SEX/DURATION
: female 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Maternal Effects - other effects
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
36,719,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 12480 ug/kg
SEX/DURATION
: male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
190,280,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 4032 ug/kg
SEX/DURATION
: male 42 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 151,502,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 1700 ug/kg
SEX/DURATION
: female 51 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
66,459,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 1429 ug/kg
SEX/DURATION
: female 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Maternal Effects - other effects
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 95,709,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 1200 ug/kg
SEX/DURATION
: female 40 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
66,1855,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 16 mg/kg
SEX/DURATION
: female 17 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
125,400,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 4600 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 74,287,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
351,187,1996
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 7 mg/kg/8W (Intermittent)
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.11969Volume(issue)/page/year: 65,115,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
417,75,1998
*** STATUS IN U.S. ***
NTP Carcinogenesis studies; selected, May 1999
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
MELPHALAN
RTECS NUMBER
CHEMICAL NAME
LCAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
: AY3675000
: Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,
:
:
:
:
:
:
:
:
:
148-82-3
2816456
4-14-00-01689 (Beilstein Handbook Reference)
199907
95
C13-H18-Cl2-N2-O2
305.23
QVYZ1R DN2G2G -L
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Alanine nitrogen mustard
* Alkeran
* L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
* p-Bis(beta-chloroethyl)aminophenylalanine
* p-N-Bis(2-chloroethyl)amino-L-phenylalanine
* 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine
* 4-(Bis(2-chloroethyl)amino)-L-phenylalanine
* CB 3025
* 3025 C.B.
* p-Di-(2-chloroethyl)amino-L-phenylalanine
* p-N-Di(chloroethyl)aminophenylalanine
* 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine
* Levofalan
* Melfalan
* Melphalan
* NCI-C04853
* L-PAM
* L-Phenylalanine, 4-(bis(2-chloroethyl)amino)* Phenylalanine mustard
* L-Phenylalanine mustard
* Phenylalanine nitrogen mustard
* RCRA waste number U150
* L-Sarcolysin
* p-L-Sarcolysin
* L-Sarcolysine
* L-Sarkolysin
* SK-15673
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Rinsed with water
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/24H
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 14,117,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 pph/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB270-483
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 700 mg/kg/7D
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,367,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1200 ug/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC)
V.52(6)-59,
1968-75. For publisher information, see CTRRDO.
Volume(issue)/page/year:
57,369,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 4500 mg/kg
TOXIC EFFECTS :
Behavioral - anorexia (human)
Gastrointestinal - hypermotility, diarrhea
Blood - agranulocytosis
REFERENCE :
NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O.
Box
156, Wellington, New Zealand) V.11900- Volume(issue)/page/year:
97,816,1984
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 8140 mg/kg
TOXIC EFFECTS :
Behavioral - anorexia (human)
Gastrointestinal - hypermotility, diarrhea
Blood - agranulocytosis
REFERENCE :
NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O.
Box
156, Wellington, New Zealand) V.11900- Volume(issue)/page/year:
97,816,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Blood - agranulocytosis
Blood - thrombocytopenia
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1Volume(issue)/page/year: 2,1048,1984
1823-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 10,710,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4484 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
13,969,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 10,710,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 18,760,1966
TYPE OF TEST
: LD10 - Lethal Dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981.
For
publisher information, see EJCODS. Volume(issue)/page/year: 10,667,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20800 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB88-133921
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
47,62,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Unreported
Rodent - mouse
29600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,2703,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 3 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Blood - normocytic anemia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB88-133921
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 mg/kg/7D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Immunological Including Allergic - decrease in humoral immune response
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 107,47,1996
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 80 ug/kg/D-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - other changes
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO
63379)
V.11946- Volume(issue)/page/year: 41,17,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 57 ug/kg/D-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - other changes
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
BLOOAW Blood.
63379)
V.11946-
(Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO
Volume(issue)/page/year: 41,17,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 26 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
JCPAAK Journal of Clinical Pathology. (British Medical Journal, Box
560B,
Kennebunkport, ME 04046) V.11947- Volume(issue)/page/year:
26,649,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965Volume(issue)/page/year: 52,1,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 58 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
10,363,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965-
Volume(issue)/page/year: 52,1,1975
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
37,317,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 66 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO
63379)
V.11946- Volume(issue)/page/year: 44,333,1974
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 34 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
SJHAAQ Scandinavian Journal of Haematology. (Munksgaard International
Pub.,
POB 2148, DK-1016 Copenhagen K, Denmark) V.11964Volume(issue)/page/year: 8,375,1971
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 12 mg/kg/3Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)
V.211967- Volume(issue)/page/year: 40,268,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 23 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
211,203,1982
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 17 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
211,203,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 3750 ug/kg
SEX/DURATION
: female 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,1174,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - child
DOSE
: 8800 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - other effects
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,1425,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - woman
DOSE
: 5946 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,1425,1987
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie,
Stomatologie, Seria: Oncologia. (Rompresfilatelia, POB 12-201,
Bucharest,
Romania) V.13(4)1974- Volume(issue)/page/year: 18,95,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 200 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 72,5135,1975
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 ug/disc
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,1658,1974
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,235,1996
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 10700 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
30,195,1970
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
242,169,1990
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Sex chromosome loss and nondisjunction
Unreported
Insect - Drosophila melanogaster
10 mmol/L
ANYAA9 Annals of the New York Academy of Sciences.
Sciences, 2 E. 63rd St., New York, NY 10021) V.1Volume(issue)/page/year: 160,228,1969
(New York Academy of
1877-
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
EJHAEC European Journal of Haematology. (Munksgaard International
Publishers, POB 2148, DK-1016 Copenhagen K, Denmark) V.381987Volume(issue)/page/year: 47,161,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L/1H (Continuous)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1169,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens
907,
Greece) V.11981- Volume(issue)/page/year: 10,297,1990
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lung
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,83,1998
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
38,3122,1989
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 800 ug/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 21,151,1981
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106)
42,84,1982
V.1-
1941-
Volume(issue)/page/year:
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,84,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Bone marrow
DOSE/DURATION
: 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,84,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 25 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.151,191,1984
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 4 mg/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 21,438,1978
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon
Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)
V.17(7)25, 1981-89. For publisher information, see EJCAEL
Volume(issue)/page/year:
17,991,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens
907,
Greece) V.11981- Volume(issue)/page/year: 10,297,1990
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 150 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,361,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 21,438,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
19,225,1973
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 400 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,605,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 umol/L
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87.
For
publisher information, see JNCIEQ. Volume(issue)/page/year: 69,505,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 umol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon
Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)
V.17(7)25, 1981-89. For publisher information, see EJCAEL
Volume(issue)/page/year:
17,991,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sister chromatid exchange
: Human Lymphocyte
: 100 ug/L
EMMUEG Environmental and Molecular Mutagenesis.
(Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003)
14,6,1989
V.10-
1987-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 160 nmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
39,191,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1250 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
389,3,1997
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 ug/L
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 1,277,1978
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
282,151,1992
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 100 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
37,2202,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 40 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
37,3189,1988
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,246,1983
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 37600 nmol/kg
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,248,1983
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 37700 nmol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,2340,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2 mg/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 25,378,1975
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 2 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2025,1985
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1500 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),32,1986
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Dominant lethal test
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 7500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
345,167,1995
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 ug/L
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 1,277,1978
TYPE OF TEST
: Heritable translocation test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 7500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
345,167,1995
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
35,1163,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 3 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,3175,1983
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
37,2202,1977
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 5 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,797,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 2500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,235,1996
*** REVIEWS ***
IARC Cancer Review:Human Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,239,1987
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 9,167,1975
IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,239,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4742
No. of Facilities: 140 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 2418 (estimated)
No. of Female Employees: 974 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell
transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human; E coli
polA
with S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
NCI Carcinogenesis Studies (ipr);clear evidence:mouse,rat
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965Volume(issue)/page/year: 52,1,1975
NTP 8th Annual Report on Carcinogens, 1998: Known to be human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
MENTHOL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OT0350000
Menthol
89-78-1
1902288
2-06-00-00052 (Beilstein Handbook Reference)
199904
11
C10-H20-O
156.30
L6TJ AY1&1 BQ D1
Agricultural Chemical
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1-alpha,2-beta,5-alpha)* Cyclohexanol, 2-isopropyl-5-methyl* Hexahydrothymol
* p-Menthan-3-ol
* Menthol, cis-1,3,trans-1,4* Menthomenthol
* 5-Methyl-2-(1-methylethyl)cyclohexanol
* Peppermint camphor
* Tra-kill tracheal mite killer
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ug
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611)
Volume(issue)/page/year: 29,1363,1946
Series 3: V.1-
1918-
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3180 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - hallucinations, distorted perceptions
Behavioral - muscle weakness
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 10,481,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 222,244,1954
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 63,43,1939
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Mammal - cat
1500 mg/kg
V.4-
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 63,43,1939
V.4-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 22400 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - fluid intake
Liver - changes in liver weight
Blood - changes in other cell count (unspecified)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
19,207,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44440
No. of Facilities: 3689 (estimated)
No. of Industries: 36
No. of Occupations: 35
No. of Employees: 25754 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 44440
No. of Facilities: 2880 (estimated)
No. of Industries: 28
No. of Occupations: 33
No. of Employees: 44233 (estimated)
No. of Female Employees: 31143 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MENTHOL (1R,2S,5R-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OT0700000
l-Menthol
2216-51-5
199701
16
C10-H20-O
156.30
L6TJ AY1&1 DQ D1
Mutagen
Natural Product
Primary Irritant
-L
SYNONYMS/TRADE NAMES :
* (-)-Menthol
* (1R,3R,4S)-(-)-Menthol
* (-)-Menthyl alcohol
* (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
* U.S.P. Menthol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga,
113095
Moscow, USSR) V.31930- Volume(issue)/page/year: 17(3),53,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 35,110,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
5,233,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga,
113095
Moscow, USSR) V.31930- Volume(issue)/page/year: 17(3),53,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 34 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 63,43,1939
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,471,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 63,43,1939
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
: DNA repair
: Bacteria - Bacillus subtilis
V.4-
DOSE/DURATION
: 10 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical
Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54
Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.241975- Volume(issue)/page/year:
34,267,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6896
No. of Facilities: 499 (estimated)
No. of Industries: 5
No. of Occupations: 27
No. of Employees: 43996 (estimated)
No. of Female Employees: 34625 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MENTHOL (DL-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OT0525000
dl-Menthol
15356-70-4
3194263
4-06-00-00151 (Beilstein Handbook Reference)
199904
21
C10-H20-O
156.30
L6TJ AY1&1 DQ D1
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1-alpha,2-beta,5-alpha)
* 4-Isopropyl-1-methylcyclohexan-3-ol
* Menthol, cis-1,3-trans-1,4-(+-)* (+-)-Menthol
* 3-p-Menthol
* dl-3-p-Menthanol
* Menthol racemic
* NCI-C50000
* Menthol racemique
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,473,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga,
113095
Moscow, USSR) V.31930- Volume(issue)/page/year: 17(3),53,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 670 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - hallucinations, distorted perceptions
Behavioral - muscle weakness
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 10,481,1952
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 73,2011,1926
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
5,233,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga,
113095
Moscow, USSR) V.31930- Volume(issue)/page/year: 17(3),53,1962
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 73,2011,1926
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 73,2011,1926
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 73,2011,1926
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,473,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 865 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - hallucinations, distorted perceptions
Behavioral - muscle weakness
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 10,481,1952
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 700 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,181,1994
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 725 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,189,1994
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1991
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 427 (estimated)
No. of Female Employees: 176 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-98,1979
MERCAPTO METHYLIMIDAZOLE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
(2:1-)
: NI8615000
: Imidazole-2-thiol, 1-methyl: 60-56-0
: 199812
: 30
: C4-H6-N2-S
MOLECULAR WEIGHT
: 114.18
WISWESSER LINE NOTATION : T5N CNJ A BSH
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Basolan
* Danantizol
* Favistan
* Frentirox
* Imidazole, 1-methyl-2-mercapto* Imidazole-2-thio, 1-methyl* Mercaptazole
* 2-Mercapto-1-methylimidazole
* Mercasolyl
* Mercazole
* Mercazolyl
* Merkazolil
* Metazolo
* Methiamazole
* Methimazol
* Methimazole
* 1-Methylimidazole-2-thiol
* Methylmercaptoimidazole
* 1-Methyl-2-mercaptoimidazole
* Metizol
* Metothyrine
* 1-Metylo 2 merkaptoimidazolem
* Strumazole
* Tapazole
* Thacapzol
* Thiamazole
* Thycapzol
* USAF EL-30
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 492 mg/kg/88W-I
TOXIC EFFECTS :
Endocrine - changess in gonadotropins
Blood - agranulocytosis
REFERENCE :
NLJMAV Netherlands Journal of Medicine. (Elsevier Science, POB 211, 1000
AE
Amsterdam. Netherlands) V.161973- Volume(issue)/page/year:
43,71,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 2250 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 4,20,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 14,54,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 860 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 4,20,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Peripheral Nerve and
sensory
change
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
345 mg/kg
Sensation - spastic paralysis with or without
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 4,20,1954
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 580 mg/kg/1W-C
TOXIC EFFECTS :
Endocrine - evidence of thyroid hypofunction
Endocrine - changes in thyroid weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.121952Volume(issue)/page/year: 32,659,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/12D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 4,20,1954
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1100 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - thyroid tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,649,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 33 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - thyroid tumors
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 40,2188,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2700 mg/kg/26W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 174,268,1980
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - woman
DOSE
: 145 mg/kg
SEX/DURATION
: female 1-34 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ZEGYAX Zentralblatt fuer Gynaekologie. (Johann Ambrosius Barth Verlag,
Postfach 109, DDR-7010, Leipzig, Ger. Dem. Rep.) V.11877Volume(issue)/page/year: 88,218,1966
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
80 mg/kg
female 17-22 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 31,64A,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
600 mg/kg
female 15-22 day(s) after conception
lactating female 7 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968-
Volume(issue)/page/year: 29(2),4B,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
320 mg/kg
female 17-22 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A30,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1100 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
PIAIA9 Proceedings of the Iowa Academy of Science. (Iowa Academy of
Science, Exec. Dir., Univ. of Northern Iowa, Cedar Falls, IA 50613) V.11887/93- Volume(issue)/page/year: 72,462,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
160 mg/kg
female 17-22 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 27,79A,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
567 mg/kg
female 17-22 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,133,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1530 ug/kg
SEX/DURATION
: female 18-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc.,
9650
Rockville Pike, Bethesda, MD 20814) V.11898Volume(issue)/page/year:
257,L94,1989
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
320 mg/kg
female 16-21 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 27,71A,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
320 mg/kg
female 16-21 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,69,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
1152 mg/kg
female 16-21 day(s) after conception
lactating female 10 day(s) post-birth
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 8,531,1987
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 2500 ug/L
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 26,155,1975
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Mammary gland
DOSE/DURATION
: 3200 umol/L/24H (Continuous)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 5,141,1980
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 28 mg/kg/2W (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
326,193,1995
*** REVIEWS ***
TOXICOLOGY REVIEW
PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W.
Washington Sq., Philadelphia, PA 19105) V.11954Volume(issue)/page/year: 8,413,1961
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83970
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 297 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83970
No. of Facilities: 23 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 707 (estimated)
No. of Female Employees: 239 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCAPTOACETIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
AI5950000
Acetic acid, mercapto68-11-1
0506166
4-03-00-00600 (Beilstein Handbook Reference)
199907
32
C2-H4-O2-S
92.12
SH1VQ
Agricultural Chemical
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acide thioglycolique
* Glycolic acid, thio* Glycolic acid, 2-thio* Kyselina merkaptooctova
* Kyselina thioglykolova
* Mercaptoacetate
* Mercaptoacetic acid
* alpha-Mercaptoacetic acid
* 2-Mercaptoacetic acid
* Thioglycolic acid
* 2-Thioglycolic acid
* Thioglycolic acid
* Thioglycollic acid
* Thiovanic acid
* USAF CB-35
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 3%
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 15,669,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 114 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,575,1974
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >620 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1541,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,575,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 242 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,575,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982
Volume(issue)/page/year: -,111,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 47 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University,
Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.11949Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 138 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 31,1713,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
60,278,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,575,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Administration onto the skin
Rodent - rabbit
300 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(1),48,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
41,325,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,586,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 157 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,575,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(4),86,1974
(V/O
*** REVIEWS ***
ACGIH TLV-TWA 3.8 mg/m3 (1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (4 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1 ppm (3.8 mg/m3) JAN 1993
OEL-DENMARK: TWA 1 ppm (5 mg/m3), JAN1999
OEL-FINLAND:TWA 1 ppm (5 mg/m3);STEL 3 ppm (15 mg/m3) JAN 1993
OEL-HUNGARY:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (4 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (3.8 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 4 mg/m3, MAC(STEL) 8 mg/m3, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO THIOGLYCOLIC ACID-air:10H TWA 1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83835
No. of Facilities: 5167 (estimated)
No. of Industries: 10
No. of Occupations: 9
No. of Employees: 35238 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83835
No. of Facilities: 2428 (estimated)
No. of Industries: 10
No. of Occupations: 12
No. of Employees: 30055 (estimated)
No. of Female Employees: 15141 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCAPTOACETIC ACID SODIUM
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
AI7700000
Acetic acid, mercapto-, monosodium salt
367-51-1
199907
14
C2-H3-O2-S.Na
114.10
SH1VQ &-NATumorigen
Drug
Primary Irritant
SYNONYMS/TRADE NAMES :
* Mercaptoacetic acid sodium salt
* Sodium mercaptoacetate
* Sodium thioglycolate
* Sodium thioglycollate
* Thioglycolate sodium
* Thioglycollic acid, sodium salt
* USAF EK-5199
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 7%/24H
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 15,669,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 126 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 118,296,1956
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 504 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 118,296,1956
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 293 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 41,105,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 422 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 38,137,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CJTEAO Canadian Journal of Technology. (Ottawa, Ont., Canada)
V.29(1)-34(8), 1951-57, Continues Canadian Journal of Research. Section
F.,
Changed to Canadian Journal of Chemical Engineering.
Volume(issue)/page/year: 34,21,1956
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 118,296,1956
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 118,296,1956
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 35,343,1929
V.1-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84380
No. of Facilities: 265 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 3978 (estimated)
NOES - National Occupational Exposure Survey (1983)
1909/10-
NOES Hazard Code - 84380
No. of Facilities: 605 (estimated)
No. of Industries: 3
No. of Occupations: 10
No. of Employees: 7551 (estimated)
No. of Female Employees: 6204 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis studies; selected, May 1999
MERCAPTOBENZIMIDAZOLE (2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
OTHER CAS REGISTRY NOS. :
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
DE1050000
2-Benzimidazolethiol
583-39-1
2080-59-3
199701
12
C7-H6-N2-S
150.21
T56 BM DNJ CSH
Drug
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Antiegene MB
* Antioxidant MB
* AOMB
* ASM MB
* 2-Benzimidazolinthion
* 2-Mercaptobenzimidazole
* Mercaptobenzoimidazole
* 2-Mercaptobenzoimidazole
* Merkaptobenzimidazol
* 2-Merkaptobenzimidazol
* NCI-C60980
* o-Phenylenethiourea
* USAF EK-6540
* USAF XF-21
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/24H
Mild
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,990,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,990,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga,
113095
Moscow, USSR) V.31930- Volume(issue)/page/year: 17(1),36,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04376
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
6200 ug/m3/6H/13W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Endocrine - changes in thyroid weight
Blood - changes in erythrocyte (RBC) count
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16,161,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1820 mg/kg/17W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 8(7),39,1964
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 660 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 25,218,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 110 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 25,218,1995
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
330 mg/kg
female 7-17 day(s) after conception
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 25,218,1995
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2477
No. of Facilities: 43 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 304 (estimated)
No. of Female Employees: 67 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCAPTOBENZOTHIAZOLE (2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
DL6475000
2-Benzothiazolethiol
149-30-4
199904
29
C7-H5-N-S2
167.25
T56 BN DSJ CSH
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzothiazole-2-thione
* 2(3H)-Benzothiazolethione
* 2-Benzothiazolyl mercaptan
* Captax
* Kaptax
* MBT
* Mercaptobenzothiazole
* 2-Mercaptobenzothiazole
* 2-Merkaptobenzotiazol
* 2-Merkaptobenzthiazol
* NCI-C56519
* Pennac MBT powder
* Rokon
* Rotax
*
*
*
*
Sulfadene
USAF GY-3
USAF XR-29
Vulkacit mercapto
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1270 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-1190-0987S
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 16,35,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1158 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University,
Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan)
Volume(issue)/page/year: 36(1-4),10,1989
V.1-
1949-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >7940 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,62,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535428
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12220 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
18 gm/kg/16D-I
(Research
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 97500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 174 gm/kg/86W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(107),44,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 770 mg/kg/7D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - liver function tests impaired
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
14,221,1969
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 195 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Gastrointestinal - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 35 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 215 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 195 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Parenteral
Rodent - rat
800 mg/kg
male 2 day(s) pre-mating
female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 93,107,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 4-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 93,107,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4176 mg/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 351 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
(Research
*** REVIEWS ***
TOXICOLOGY REVIEW
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.101968Volume(issue)/page/year: 15,808,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84030
No. of Facilities: 2428 (estimated)
No. of Industries: 45
No. of Occupations: 40
No. of Employees: 42637 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84030
No. of Facilities: 4825 (estimated)
No. of Industries: 74
No. of Occupations: 62
No. of Employees: 86509 (estimated)
No. of Female Employees: 16409 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
(Research
NTP Carcinogenesis Studies (gavage);equivocal evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-332,1988
MERCAPTOBENZOXAZOLE (2-)
RTECS NUMBER
: DM4882500
CHEMICAL NAME
: 2-Benzoxazolethiol
CAS REGISTRY NUMBER
: 2382-96-9
LAST UPDATED
: 199812
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C7-H5-N-O-S
MOLECULAR WEIGHT
: 151.19
WISWESSER LINE NOTATION : T56 BN DOJ CSH
SYNONYMS/TRADE NAMES :
* 2-Benzoxazolethione
* 2(3H)-Benzoxazolethione
* 2-Benzoxazolinethione
* 2-Benzoxazolylthiol
* 2-Mercaptobenzoxazole
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571529
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04482
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCAPTOETHANOL (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KL5600000
Ethanol, 2-mercapto60-24-2
0773648
4-01-00-02428 (Beilstein Handbook Reference)
199710
20
C2-H6-O-S
78.14
SH2Q
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Emery 5791
* 1-Ethanol-2-thiol
* Ethylene glycol, monothio-
*
*
*
*
*
*
*
*
*
*
2-Hydroxy-1-ethanethiol
2-Hydroxyethyl mercaptan
2-ME
Mercaptoethanol
beta-Mercaptoethanol
2-Mercaptoethanol
Monothioethyleneglycol
2-Thioethanol
Thiomonoglycol
USAF EK-4196
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 244 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),56,1971
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),56,1971
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13200 mg/m3
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),56,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 480 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 62,237,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Rodent - rabbit
DOSE/DURATION
: 150 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3220 mg/kg/4W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 62,237,1973
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 77,1150,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.311951- Volume(issue)/page/year:
166,400,1975
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Micronucleus test
: Rodent - mouse Cells - not otherwise specified
: 100 mg/L
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
56,357,1976
(Washington, DC)
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 30 mmol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
425,1,1976
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84674
No. of Facilities: 133 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 1437 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84674
No. of Facilities: 1497 (estimated)
No. of Industries: 5
No. of Occupations: 13
No. of Employees: 14140 (estimated)
No. of Female Employees: 4607 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCAPTOETHYLAMINE HYDROCHLORIDE
RTECS NUMBER
: KJ0200000
CHEMICAL NAME
: Ethanethiol, 2-amino-, hydrochloride
CAS REGISTRY NUMBER
: 156-57-0
OTHER CAS REGISTRY NOS. : 116962-86-8
LAST UPDATED
: 199701
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C2-H7-N-S.Cl-H
MOLECULAR WEIGHT
: 113.62
WISWESSER LINE NOTATION : Z2SH &GH
COMPOUND DESCRIPTOR
: Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Bekaptan
* Cysteamine hydrochloride
* Cysteaminhydrochlorid
* Ethylamine, 2-mercapto-, hydrochloride
* beta-Mercaptoaethylamin chlorhydrat
* Mercaptoethylamine hydrochloride
* beta-Mercaptoethylamine hydrochloride
* 2-Mercaptoethylamine hydrochloride
* USAF EE-3
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1352 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103) V.61958Volume(issue)/page/year: 20,721,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 12,510,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ABPAAG Acta Biologiae Experimentalis (Warszawa). (Nencki Institute of
Experimental Biology) V.1-13, 1928-39; V.14-29, 1947-69.
Volume(issue)/page/year: 12,142,1938
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Unreported
Rodent - mouse
244 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
14,132,1959
** MUTATION DATA **
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
334,317,1995
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
153,57,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCAPTOIMIDAZOLE (2-)
RTECS NUMBER
: NI8515000
CHEMICAL NAME
: Imidazole-2-thiol
CAS REGISTRY NUMBER
: 872-35-5
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C3-H4-N2-S
MOLECULAR WEIGHT
: 100.15
WISWESSER LINE NOTATION : T5M CNJ BSH
SYNONYMS/TRADE NAMES :
* Imidazole, 2-mercapto* 2-Mercaptoimidazole
* USAF EL-57
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCAPTOPYRIDINE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 2-Mercaptopyridine
* 2-Pyridinethiol
* 2-Thiopyridine
* Thiopyridone-2
:
:
:
:
:
:
:
:
:
:
UT9600000
2(1H)-Pyridinethione
2637-34-5
1120-96-3
199701
3
C5-H5-N-S
111.17
T6NJ BSH
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 93,143,1953
V.4-
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCAPTOSUCCINIC ACID
RTECS NUMBER
: WM8225000
CHEMICAL NAME
: Succinic acid, mercaptoCAS REGISTRY NUMBER
: 70-49-5
BEILSTEIN REFERENCE NO. : 1099858
REFERENCE
: 4-03-00-01130 (Beilstein Handbook Reference)
LAST UPDATED
: 199901
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C4-H6-O4-S
MOLECULAR WEIGHT
: 150.16
WISWESSER LINE NOTATION : SHYVQ1VQ
SYNONYMS/TRADE NAMES :
* Malic acid, 2-thio* Mercaptosuccinate
* Mercaptosuccinic acid
* 2-Mercaptosuccinic acid
* Thiomalic acid
* USAF EK-P-6297
* USAF M-2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906-
Volume(issue)/page/year:
41,325,1947
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCAPTOTHIAZOLINE (2-)
RTECS NUMBER
: XJ6122000
CHEMICAL NAME
: 2-Thiazolidinethione
CAS REGISTRY NUMBER
: 96-53-7
LAST UPDATED
: 199706
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C3-H5-N-S2
MOLECULAR WEIGHT
: 119.21
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Metabasal
* Sancelent 2MT
* Tetrahydrothiazole-2-thione
* 2-Thiothiazolidone
* Thyroidan
* WR 305
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 90,260,1947
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 97,478,1949
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 14,111,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St.,
Duluth,
MN 55802) V.11954- Volume(issue)/page/year: 7,22,1957
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7939
No. of Facilities: 17 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1881 (estimated)
No. of Female Employees: 302 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCURIC ACETATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
AI8575000
Acetic acid, mercury(2+) salt
1600-27-7
6129-23-3
7619-62-7
19701-15-6
199907
49
C4-H6-O4.Hg
318.69
QV1 &QV1 &-HGTumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bis(acetyloxy)mercury
* Diacetoxymercury
* Mercuriacetate
* Mercuric acetate
* Mercuric diacetate
* Mercury(2+) acetate
* Mercury(II) acetate
* Mercury diacetate
* Mercuryl acetate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(8),12,1981
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 23900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(8),12,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
(V/O
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie.
(Vienna,
Austria) V.1-108, 1867-1974. For publisher information, see LROTDW.
Volume(issue)/page/year: 73,751,1939
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4390 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
57,219,1961
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4246 mg/kg/1Y-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 2,433,1950
** REPRODUCTIVE DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
3 mg/kg
female 10 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 7,382,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 25 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 35 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 50 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 4 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - hamster
15 mg/kg
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 25,726,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
LSBGAY Life Sciences, Part 2: Biochemistry, General and Molecular
Biology.
(New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK.
Volume(issue)/page/year: 10,1341,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 4 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 6,95,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 4 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 8,207,1974
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
17,93,1973
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
27,30,1996
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Hg)/m3; STEL 0.03 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 126,390,1976
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83751
No. of Facilities: 109 (estimated)
No. of Industries: 4
No. of Occupations: 4
No. of Employees: 856 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83751
No. of Facilities: 320 (estimated)
No. of Industries: 11
No. of Occupations: 10
No. of Employees: 6064 (estimated)
No. of Female Employees: 2770 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCURIC BROMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Mercuric bromide
:
:
:
:
:
:
:
:
OV7415000
Mercury(II) bromide (1:2)
7789-47-1
199907
27
Br2-Hg
360.41
HG E2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82901
No. of Facilities: 29 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 265 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCURIC CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OV9100000
Mercury(II) chloride
7487-94-7
199907
170
Cl2-Hg
271.49
HG G2
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Abavit B
* Bichloride of mercury
* Bichlorure de mercure
* Calochlor
* Chlorid rtutnaty
* Chlorure mercurique
* Cloruro di mercurio
* Corrosive mercury chloride
* Corrosive sublimate
* Dichloromercury
* Fungchex
* Mercuric bichloride
* Mercury bichloride
* Mercury(2+) chloride
* Mercury dichloride
* Mercury perchloride
* NCI-C60173
* Perchloride of mercury
* Quecksilber chlorid
* Sulem
* Sulema
* Sublimat
* Sublimate
* TL 898
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,12,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,12,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 57 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
Liver - liver function tests impaired
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.11988Volume(issue)/page/year: 8,157,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 21 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 11,309,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 86 mg/kg
TOXIC EFFECTS :
Vascular - change in plasma or blood volume
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - necrotic changes
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
26,189,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased
Blood - other changes
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel
Road,
Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990Volume(issue)/page/year: 11,53,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 80,145,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from duodenum
Gastrointestinal - ulceration or bleeding from large intestine
Gastrointestinal - nausea or vomiting
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
244,459,1951
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory obstruction
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co.
Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.11914Volume(issue)/page/year: 2,125,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 7253 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
9,550,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3210 ug/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug
Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 12,247,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya
Book-Stores
of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
Webster St., San Francisco, CA 94115) V.71928Volume(issue)/page/year:
39,47,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1272 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
58,243,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),76,1986
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year:
No.9-4-1-9,1943
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 25,891,1991
No.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 34,193,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4992 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
21,364,1948
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg,
Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 2710 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 44,423,1932
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg,
Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Intravenous
Rodent - rabbit
2 mg/kg
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 35,343,1929
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 7300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 87,119,1946
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
11,201,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
11,201,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1389,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1389,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 36 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,105,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 34 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,105,1987
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 2424 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg,
Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg,
Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 7579 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 85,253,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 412 mg/kg/61D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 102(Suppl 3),305,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 420 mg/kg/4W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - changes in adrenal weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
31,125,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 675 mg/kg/27W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 36,319,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 160 mg/kg/16D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-408,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2600 mg/kg/2Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 36,319,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 455 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - evidence of thyroid hypofunction
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
48,49,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 592 mg/kg/50W-C
TOXIC EFFECTS :
Cardiac - other changes
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978-
Volume(issue)/page/year: 13,353,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5950 ug/kg/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(5),46,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44955 ug/kg/45D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological
Society, 27 Tai-Ping Road, Beijing 100850, China) V.11986Volume(issue)/page/year: 1,147,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17647 ug/kg/5W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 79,119,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3520 mg/m3/24H/17W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),11,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intraperitoneal
: Rodent - rat
(V/O
DOSE/DURATION
: 30 ug/kg/6D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine,
75008
Paris, France) V.11978- Volume(issue)/page/year: 1,263,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 128 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (4),24,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg/16D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thymus weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-408,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 650 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-408,1993
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg/10D-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
6,319,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg/12W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Endocrine - other changes
Blood - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
144,163,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 25 mg/kg/13W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
129,196,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2800 mg/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 7,522,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 4260 ug/kg/6W-C
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 12,46,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Bird - quail
560 mg/kg/5D-C
Behavioral - food intake (animal)
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,105,1987
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 50 ug/kg
SEX/DURATION
: female 10 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 80,145,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 240 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25(1),26A,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 120 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25(1),26A,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2470 ug/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.11932- Volume(issue)/page/year:
55,734,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
919 mg/kg
male 12 week(s) pre-mating
female 2 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
BESCE5 Biomedical and Environmental Sciences. (Academic Press, 525 B
St.,
Suite 1900, San Diego, CA 92101) V.11988Volume(issue)/page/year:
9,437,1996
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2720 ng/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),67,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 19540 ng/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),67,1981
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 276 ng/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),67,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India
Institute
of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110
029,
India) V.11957- Volume(issue)/page/year: 26,246,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4500 ug/kg
SEX/DURATION
: male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
27,45,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4500 ug/kg
SEX/DURATION
: male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 25,542,1987
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5430 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
80 mg/kg
female 13-22 day(s) after conception
lactating female 10 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE85-015022
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1069 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
58,243,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
1069 ug/kg
female 14 day(s) after conception
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
58,243,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 21719 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 230 ug/m3/4H
SEX/DURATION
: female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
CMLMDW Collection de Medecine Legale et de Toxicologie Medicale. (Masson
Editeur, 120 Blvd. Saint- Germain, F-75280 Paris Cedex 06, France)
No.531970- Volume(issue)/page/year: 125,65,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 230 ug/m3/4H
SEX/DURATION
: female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
CMLMDW Collection de Medecine Legale et de Toxicologie Medicale. (Masson
Editeur, 120 Blvd. Saint- Germain, F-75280 Paris Cedex 06, France)
No.531970- Volume(issue)/page/year: 125,65,1984
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 30 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India
Institute
of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110
029,
India) V.11957- Volume(issue)/page/year: 26,246,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5430 ug/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2030 ug/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 33,231,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3384 ug/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,27B,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intravenous
: Rodent - mouse
DOSE
: 1353 ug/kg
SEX/DURATION
: female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 49,541,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2706 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 49,541,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 60 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India
Institute
of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110
029,
India) V.11957- Volume(issue)/page/year: 26,246,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 30 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India
Institute
of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110
029,
India) V.11957- Volume(issue)/page/year: 26,246,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8660 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25,381,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 24 mg/kg
SEX/DURATION
: female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
11,180,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 34648 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 18,166,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
8,378,1973
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 1 mg/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 40,597,1988
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 33 pph
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 67,1390,1970
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 33 pph
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 67,1390,1970
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 15 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
1,21,1986
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Fish - not otherwise specified Leukocyte
DOSE/DURATION
: 2 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,157,1994
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 12 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
292,83,1993
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 1 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
292,83,1993
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 1 ug/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.11929- Volume(issue)/page/year: 53,263,1988
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 12500 ug/kg
REFERENCE :
ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K.
Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal,
India) V.11983- Volume(issue)/page/year: 4,320,1989
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
340,175,1996
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 2 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
340,175,1996
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 10 mg/L
REFERENCE :
JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya
Book-Stores
of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
Webster St., San Francisco, CA 94115) V.71928Volume(issue)/page/year:
39,47,1969
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Cytogenetic analysis
: Human Lymphocyte
: 2 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
340,175,1996
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Ascites tumor
DOSE/DURATION
: 500 umol/L
REFERENCE :
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore,
MD
21202) V.11905- Volume(issue)/page/year: 261,3370,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
124,163,1983
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 8 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.167,185,1988
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 8 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
67,185,1988
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 250 ng/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
124,163,1983
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 2500 ug/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation).
TGANAK.
Translation of
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)
Volume(issue)/page/year: 16(2),25,1982
V.8-
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 mg/kg
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1974-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 194,171,1975
V.1-
1909/10-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 50 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,24,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Sperm
DOSE/DURATION
: 10 umol/L
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 194,171,1975
V.1-
1909/10-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 6 mg/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 9,367,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
24,489,1975
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 50 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
124,163,1983
TYPE OF TEST
TEST SYSTEM
: Unscheduled DNA synthesis
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,24,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11962- Volume(issue)/page/year:
41,371,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 nmol/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 36,297,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
24,489,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
29,777,1991
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
29,777,1991
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Dominant lethal test
Intraperitoneal
Rodent - mouse
2 mg/kg
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
30,365,1975
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 400 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,85,1988
TYPE OF TEST
: Heritable translocation test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
30,365,1975
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 50 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,193,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 12,173,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2500 nmol/L/1H (Continuous)
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,74,1983
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 25 umol/L/1H (Continuous)
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 108,614,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 40 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
18,205,1977
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2700 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
290,281,1993
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 6400 ug/kg
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25,381,1982
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1100 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,381,1985
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 1 mg/kg
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE83-770037
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bird - chicken Cells - not otherwise specified
DOSE/DURATION
: 3 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 12,173,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 33 pph
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 67,1390,1970
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Mammal - cattle Kidney
DOSE/DURATION
: 10 umol/L
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 14,509,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 126,390,1976
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 2,491,1977
TOXICOLOGY REVIEW
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 34,1858,1975
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
JAN 1993
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84274
No. of Facilities: 1553 (estimated)
No. of Industries: 22
No. of Occupations: 19
No. of Employees: 9791 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84274
No. of Facilities: 2012 (estimated)
No. of Industries: 24
No. of Occupations: 24
No. of Employees: 45491 (estimated)
No. of Female Employees: 18717 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis
rec
assay
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCURIC IODIDE RED
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
:
:
:
:
:
:
:
OW5250000
Mercury(II) iodide
7774-29-0
199907
33
Hg-I2
454.39
WISWESSER LINE NOTATION : HG I2
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Hydrargyrum bijodatum
* Mercuric iodide
* Mercury biniodide
* Mercury diiodide
* Red mercuric iodide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 357 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
ZKMEAB Zeitschrift fuer Klinische Medizin. (Berlin, Fed. Rep. Ger.)
V.1-158, 1879-1965. For publisher information, see EJCIB8.
Volume(issue)/page/year: 106,783,1927
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
17 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 ug/m3/17W-I
TOXIC EFFECTS :
Blood - eosinophilia
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(4),29,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5950 ug/kg/17W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(5),46,1984
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4870 ng/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),73,1981
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 450 ng/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),73,1981
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81888
No. of Facilities: 385 (estimated)
No. of Industries: 6
No. of Occupations: 7
No. of Employees: 2333 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81888
No. of Facilities: 272 (estimated)
No. of Industries: 8
No. of Occupations: 10
No. of Employees: 3504 (estimated)
No. of Female Employees: 1902 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCURIC NITRATE
RTECS NUMBER
: OW8225000
CHEMICAL NAME
: Mercury(II) nitrate (1:2)
CAS REGISTRY NUMBER
: 10045-94-0
LAST UPDATED
: 199907
DATA ITEMS CITED
: 29
MOLECULAR FORMULA
: N2-O6.Hg
MOLECULAR WEIGHT
: 324.61
WISWESSER LINE NOTATION : HG N-O3*2
SYNONYMS/TRADE NAMES :
* Mercury nitrate
* Mercury pernitrate
* Nitrate mercurique
* Nitric acid, mercury(II) salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie.
(Vienna,
Austria) V.1-108, 1867-1974. For publisher information, see LROTDW.
Volume(issue)/page/year: 73,751,1939
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81005
No. of Facilities: 925 (estimated)
No. of Industries: 9
No. of Occupations: 13
No. of Employees: 7651 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81005
No. of Facilities: 1345 (estimated)
No. of Industries: 14
No. of Occupations: 17
No. of Employees: 13589 (estimated)
No. of Female Employees: 6114 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCURIC OXIDE RED
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
OW8750000
Mercury(II) oxide
21908-53-2
1344-45-2
8028-34-0
199907
37
Hg-O
216.59
HG O
Agricultural Chemical
Tumorigen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* C.I. 77760
* Mercuric oxide
* Mercuric oxide, red
* Mercuric Oxide, Yellow
* Mercury monoxide
* Mercury(2+) oxide
* Oxyde de mercure
* Red mercuric oxide
* Red oxide of mercury
* Santar
* Yellow mercuric oxide
* Yellow precipitate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10800 ug/kg
SEX/DURATION
: female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.11958Volume(issue)/page/year: 15,52,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
10800 ug/kg
female 19 day(s) after conception
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.11958Volume(issue)/page/year: 15,52,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 34 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A126,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 225 mg/kg
SEX/DURATION
: female 4-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 26(1),46A,1982
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
TOXICOLOGY REVIEW
SDGTB3 Seminars in Drug Treatment. (New York, NY)
Discontinued. Volume(issue)/page/year: 1,177,1971
V.1-3, 1971-74.
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80143
No. of Facilities: 654 (estimated)
No. of Industries: 9
No. of Occupations: 10
No. of Employees: 3859 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80143
No. of Facilities: 506 (estimated)
No. of Industries: 10
No. of Occupations: 27
No. of Employees: 9517 (estimated)
No. of Female Employees: 3800 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCURIC SULFATE
RTECS NUMBER
: OX0500000
CHEMICAL NAME
: Mercury(II) sulfate (1:1)
CAS REGISTRY NUMBER
: 7783-35-9
LAST UPDATED
: 199907
DATA ITEMS CITED
: 28
MOLECULAR FORMULA
: O4-S.Hg
MOLECULAR WEIGHT
: 296.65
WISWESSER LINE NOTATION : HG S-O4
SYNONYMS/TRADE NAMES :
* Mercuric sulfate
* Mercury bisulfate
* Mercury persulfate
* Sulfate mercurique
* Sulfuric acid, mercury(2+) salt (1:1)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80303
No. of Facilities: 441 (estimated)
No. of Industries: 12
No. of Occupations: 6
No. of Employees: 1541 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80303
No. of Facilities: 476 (estimated)
No. of Industries: 11
No. of Occupations: 10
No. of Employees: 7270 (estimated)
No. of Female Employees: 4708 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCUROUS CHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Calogreen
* Calomel
* Calotab
* Chlorure mercureux
* Cyclosan
* Dimercury dichloride
* Mercurous chloride
* Mercury subchloride
OV8740000
Mercury chloride
10112-91-1
199710
9
Cl2-Hg2
472.08
Agricultural Chemical
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
9,552,1991
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 84 mg/kg/12W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(9),27,1991
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MERCUROUS NITRATE HYDRATE
RTECS NUMBER
: OW8000000
CHEMICAL NAME
: Mercury(I) nitrate (1:1)
CAS REGISTRY NUMBER
: 10415-75-5
LAST UPDATED
: 199907
DATA ITEMS CITED
: 28
MOLECULAR FORMULA
: N-O3.Hg
MOLECULAR WEIGHT
: 262.60
WISWESSER LINE NOTATION : HG N-O3
SYNONYMS/TRADE NAMES :
* Nitrate mercureux
* Nitric acid, mercury(I) salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(8),12,1981
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
49300 ug/kg
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(8),12,1981
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
20,226,1964
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84776
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 62 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84776
No. of Facilities: 87 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 1934 (estimated)
No. of Female Employees: 1316 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MERCUROUS SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: OX0480000
: Mercury(I) sulfate
: 7783-36-0
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Mercurous sulfate
:
:
:
:
:
199907
26
O4-S.2Hg
497.24
.HG2.S-O4
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 205 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 152 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),27,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04883
*** REVIEWS ***
ACGIH TLV-TWA 0.025 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
MERCURY
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
SYNONYMS/TRADE NAMES :
* Colloidal mercury
* Hydrargyrum
* KWIK
* Liquid silver
* Mercure
OV4550000
Mercury
7439-97-6
8030-64-6
51887-47-9
92355-34-5
92786-62-4
123720-03-6
199907
78
Hg
200.59
HG
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
*
*
*
*
*
*
*
*
Mercurio
Mercury
Metallic mercury
NCI-C60399
Quecksilber
Quick silver
RCRA waste number U151
RTEC
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 254 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 2,243,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 43 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Liver - jaundice, other or unclassified
Liver - other changes
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
31,487,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 44300 ug/m3/8H
TOXIC EFFECTS :
Behavioral - muscle weakness
Liver - other changes
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.101968Volume(issue)/page/year: 20,532,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 150 ug/m3/46D
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - anorexia (human)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
33,186,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 129 mg/kg/5H-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - tinnitus
Behavioral - headache
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
DERAAC Dermatologica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
10003) V.791939- Volume(issue)/page/year: 172,48,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 571 uL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - sweating
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.11908- Volume(issue)/page/year:
90,1033,1997
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 29 mg/m3/30H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 7,19,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 mg/m3/2H/11D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1-
1981-
Volume(issue)/page/year: 42,193,1998
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/24H/5W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 79,119,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8 ug/m3/6.5H/41W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 27(1),7,1962
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17 mg/m3/2H/30D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - alteration of classical conditioning
Behavioral - alteration of operant conditioning
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
12,15,1968
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg/14D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
61,511,1957
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - rat
DOSE
: 890 ng/m3/24H
SEX/DURATION
: male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(3),72,1980
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7440 ng/m3/24H
SEX/DURATION
: male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(3),72,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/m3/24H
SEX/DURATION
: female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,59A,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 ug/m3/4H
SEX/DURATION
: female 7-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11966- Volume(issue)/page/year:
778,222,1997
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Cytogenetic analysis
Unreported
Human - man
150 ug/m3
REFERENCE :
AEHLAU Archives of Environmental Health.
St.,
NW, Washington, DC 20016) V.1196034,461,1979
(Heldref Pub., 4000 Albemarle
Volume(issue)/page/year:
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.025 mg(Hg)/m3, vapor (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 126,390,1976
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 2,491,1977
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX)
V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975
TOXICOLOGY REVIEW
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1
Lambeth High St., London, SE1 7JN, UK) V.1311933Volume(issue)/page/year: 213,159,1974
TOXICOLOGY REVIEW
JDSCAE Journal of Dairy Science. (American Dairy Science Assoc., 309 W.
Clark St., Champaign, IL 61820) V.11917- Volume(issue)/page/year:
58,1767,1975
TOXICOLOGY REVIEW
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11962Volume(issue)/page/year: 13,783,1974
TOXICOLOGY REVIEW
QURBAW Quarterly Reviews of Biophysics. (Cambridge Univ. Press, The
Edinburgh Bldg., Shaftesbury Rd., Cambridge CB2 2RU, UK) V.11968Volume(issue)/page/year: 7,75,1974
TOXICOLOGY REVIEW
AEMBAP Advances in Experimental Medicine and Biology.
Corp.,
233 Spring St., New York, NY 10013) V.11967Volume(issue)/page/year:
48,463,1974
(Plenum Pub.
TOXICOLOGY REVIEW
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)
V.481915- Volume(issue)/page/year: 164,277,1974
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
2,365,1973
TOXICOLOGY REVIEW
AEMBAP Advances in Experimental Medicine and Biology.
Corp.,
233 Spring St., New York, NY 10013) V.11967Volume(issue)/page/year:
40,239,1973
(Plenum Pub.
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81.
publisher
information, see JTCTDW. Volume(issue)/page/year: 5,151,1972
For
TOXICOLOGY REVIEW
BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252,
CEP 04014, Sao Paulo, Brazil) V.11935- Volume(issue)/page/year:
41(7),208,1975
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
42,103,1972
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
NISIA9 Nippon Shika Ishikai Zasshi. Journal of the Japan Dental
Association. (Nippon Shika Ishikai, 1-20 Kudan-kita, 4-chome,
Chiyoda-ku,
Tokyo, 102 Japan) V.11948- Volume(issue)/page/year: 27,942,1974
TOXICOLOGY REVIEW
MIBUBI Mikrobiyoloji Bulteni. Bulletin of Microbiology. (c/o Dr. A.
Tevfik
Cenqiz, Ankara Universitesi Tip Fakultesi Mikrobiyoloji Ana Bilim Dah,
Ankara, Turkey) V.11967- Volume(issue)/page/year: 9,321,1975
TOXICOLOGY REVIEW
STEVA8 Science of the Total Environment.
(Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands)
Volume(issue)/page/year:
2,341,1974
V.1-
1972-
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 13,36,1977
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,63,1970
TOXICOLOGY REVIEW
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year:
2,337,1960
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
PDTNBH Paediatrician. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland)
V.11972- Volume(issue)/page/year: 6,204,1977
TOXICOLOGY REVIEW
49DXAV "Health Evaluation of Heavy Metals in Infant Formula and Junior
Food,
Proceedings of the Symposium, 1981," Schmidt, E.H.F., and A.G.
Hildebrandt,
eds., Berlin, Springer-Verlag, 1983 Volume(issue)/page/year: -,57,1983
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):CL 0.1 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 0.1 mg(Hg)/m3 , vapor (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 0.1 mg/m3,vapor (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 0.005 ppm (0.05 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 0.1 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.1 mg/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg/m3, JAN1999
OEL-HUNGARY:TWA 0.02 mg/m3;STEL 0.04 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg/m3 (vapor) JAN 1993
OEL-POLAND: MAC(TWA) vapors 0.025 mg/m3, MAC(STEL) vapors 0.2 mg/m3,
JAN1999
OEL-SWITZERLAND:TWA 0.005 ppm (0.05 mg/m3);Skin (vapor) JAN 1993
OEL-SWITZERLAND:TWA 0.01 mg/m3;Skin JAN 1993
OEL-TURKEY:TWA 0.1 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, vapor (as Hg)-air:10H TWA 0.05 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44870
No. of Facilities: 2072 (estimated)
No. of Industries: 32
No. of Occupations: 36
No. of Employees: 15002 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 44870
No. of Facilities: 2937 (estimated)
No. of Industries: 42
No. of Occupations: 67
No. of Employees: 71932 (estimated)
No. of Female Employees: 23826 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/181256/AS
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Mercury, 6009
NIOSH Analytical Method, 1996: Mercury, 6009
OSHA ANALYTICAL METHOD #ID-185S
MEROCYANINE
RTECS NUMBER
CHEMICAL NAME
: DM4866500
: 3(2H)-Benzoxazolepropanesulfonic acid,
2-(4-(1,3-dibutyltetrahydro-4,6-dioxo-2-thioxo-5(2H)pyrimidinylidene)-2-butenylidene)-, sodium salt
CAS REGISTRY NUMBER
: 62796-23-0
LAST UPDATED
: 199706
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C26-H32-N3-O6-S2.Na
MOLECULAR WEIGHT
: 569.72
WISWESSER LINE NOTATION : T56 BNYOJ B3SWO CU2U2U- ET6NYNVYVJ A4 BUS C4 &-NASYNONYMS/TRADE NAMES :
* MC 540
* Merocyanine 540
* NK 2272
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 84 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #4775625
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MES
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
QE3479500
4-Morpholineethanesulfonic acid
4432-31-9
0141319
REFERENCE
: 4-27-00-00370 (Beilstein Handbook Reference)
LAST UPDATED
: 199706
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H13-N-O4-S
MOLECULAR WEIGHT
: 195.26
SYNONYMS/TRADE NAMES :
* MES (buffering agent)
* Morpholinoethanesulfonic acid
* 2-Morpholinoethanesulfonic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
6,149,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6845
No. of Facilities: 257 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 5949 (estimated)
No. of Female Employees: 4797 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MESITALDEHYDE
RTECS NUMBER
: CU8500000
CHEMICAL NAME
: Benzaldehyde, 2,4,6-trimethylCAS REGISTRY NUMBER
: 487-68-3
BEILSTEIN REFERENCE NO. : 1364114
REFERENCE
: 4-07-00-00730 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C10-H12-O
MOLECULAR WEIGHT
: 148.22
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Mesitaldehyde
* Mesitylaldehyde
* Mesitylenecarboxaldehyde
* 2-Mesitylenecarboxaldehyde
* 2,4,6-Trimethylbenzaldehyde
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
MESITYLENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
OX6825000
Mesitylene
108-67-8
199907
17
C9-H12
120.21
1R C1 E1
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, 1,3,5-trimethyl* 3,5-Dimethyltoluene
* Fleet-X
* sym-Trimethylbenzene
* Trimethylbenzol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
20 mg/24H
Moderate
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,34,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,34,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 10 ppm
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral
nerve
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
REFERENCE :
ZUBEAQ Zeitschrift fuer Unfallmedizin und Berufskrankheiten. Revue de
Medecine des Accidents et des Maladies Professionelles. (Verlag
Berichthaus, Zwingliplatz 3, Postfach, CH-8022, Zurich, Switzerland)
V.11907- Volume(issue)/page/year: 49,265,1956
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(5),15,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1303 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,227,1954
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 mg/m3/24H/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(5),15,1979
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1800 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
412,299,1998
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-SWEDEN:TWA 25 ppm (120 mg/m3);STEL 35 ppm (170 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 25 ppm (125 mg/m3) JAN 1993
OEL-DENMARK: TWA 25 ppm (120 mg/m3), JAN1999
OEL-JAPAN: OEL 25 ppm (120 mg/m3), JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1998
No. of Facilities: 495 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 12997 (estimated)
No. of Female Employees: 231 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
MESITYLENEDIAMINE (2,4-)
RTECS NUMBER
: CZ1607000
CHEMICAL NAME
: 1,3-Benzenediamine, 2,4,6-trimethylCAS REGISTRY NUMBER
: 3102-70-3
BEILSTEIN REFERENCE NO. : 2717221
REFERENCE
: 3-13-00-00343 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C9-H14-N2
MOLECULAR WEIGHT
: 150.25
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 2,4-Mesitylenediamine
* 2,4,6-Trimethyl-1,3-benzenediamine
* 2,4,6-Trimethyl-m-phenylenediamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 630 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,677,1992
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5700 mg/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,677,1992
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD - Lethal dose
Administration onto the skin
Rodent - rabbit
>7500 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,677,1992
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 mg/plate
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,677,1992
MESITYLENESULFONYL CHLORIDE (2-)
RTECS NUMBER
: DB8930000
CHEMICAL NAME
: Benzenesulfonyl chloride, 2,4,6-trimethylCAS REGISTRY NUMBER
: 773-64-8
BEILSTEIN REFERENCE NO. : 1107601
REFERENCE
: 3-11-00-00346 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H11-Cl-O2-S
MOLECULAR WEIGHT
: 218.71
WISWESSER LINE NOTATION : WSGR B1 D1 F1
SYNONYMS/TRADE NAMES :
* 2-Mesitylenesulfonyl chloride
* 2,4,6-Trimethylbenzenesulfonyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02913
METHACROLEIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OZ2625000
Methacrylaldehyde
78-85-3
1209258
4-01-00-03455 (Beilstein Handbook Reference)
199903
9
C4-H6-O
70.10
VHY1&U1
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acrolein, 2-methyl* Isobutenal
* Methacrolein
* Methacrylic aldehyde
* Methakrylaldehyd
* alpha-Methylacrolein
* 2-Methylacrolein
* Methylacrylaldehyde
* 2-Methylpropenal
* NSC 8260
* 2-Propenal, 2-methyl*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,271,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,271,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
140 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/21/1965
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 125 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,343,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 430 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,60,1949
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
148,25,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,305,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 7100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,69,1998
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHACRYLIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
OZ2975000
Methacrylic acid
79-41-4
1719937
4-02-00-01518 (Beilstein Handbook Reference)
199907
34
C4-H6-O2
86.10
QVY1&U1
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Acrylic acid, 2-methyl* Kyselina methakrylova
* Methacrylic acid
* alpha-Methylacrylic acid
* 2-Methylpropenoic acid
* 2-Propenoic acid, 2-methyl* Propionic acid, 2-methylene*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(4),6,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(10),64,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
1250 mg/kg
(V/O
(V/O
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(11),57,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 62,778,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(10),64,1984
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 95200 nL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 63,376,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(8),13,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Rodent - rabbit
(V/O
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,362,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4953,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 910 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(8),13,1973
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 221 mg/m3/24H/17W-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),10,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 221 mg/m3/24H/17W-C
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),10,1981
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 910 mg/kg/26W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Nutritional and Gross Metabolic - metabolic acidosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(8),13,1973
(V/O
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
*** REVIEWS ***
ACGIH TLV-TWA 70 mg/m3 (20 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,141,1975
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 20 ppm (70 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 20 ppm (70 mg/m3), JAN1999
OEL-BELGIUM:TWA 20 ppm (70 mg/m3) JAN 1993
OEL-DENMARK: TWA 20 ppm (70 mg/m3), JAN1999
OEL-GERMANY:TWA 50 ppm (210 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 20 ppm (70 mg/m3) JAN 1993
OEL-RUSSIA:STEL 101 mg/m3;Skin JAN 1993
OEL-SWEDEN:TWA 20 ppm (70 mg/m3);STEL 30 ppm (100 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 20 ppm (70 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 20 ppm (70 mg/m3);STEL 40 ppm (140 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHACRYLIC ACID-air:10H TWA 20 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3304
No. of Facilities: 1529 (estimated)
No. of Industries: 12
No. of Occupations: 31
No. of Employees: 18977 (estimated)
NOES - National Occupational
NOES Hazard Code - M3304
No. of Facilities: 10110
No. of Industries: 109
No. of Occupations: 75
No. of Employees: 145414
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
46453 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHACRYLIC ACID METHYL ESTER
RTECS NUMBER
: OZ5075000
CHEMICAL NAME
: Methacrylic acid, methyl ester
CAS REGISTRY NUMBER
: 80-62-6
BEILSTEIN REFERENCE NO. : 0605459
REFERENCE
: 4-02-00-01519 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 102
MOLECULAR FORMULA
: C5-H8-O2
MOLECULAR WEIGHT
: 100.13
WISWESSER LINE NOTATION : 1UY1&VO1
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acrylic acid, 2-methyl-, methyl ester
* Metakrylan metylu
* Methacrylate de methyle
* Methacrylsaeuremethyl ester
* 2-(Methoxycarbonyl)-1-propene
* Methylester kyseliny methakrylove
* Methylmethacrylaat
* Methyl-methacrylat
* Methyl methacrylate
* Methyl methacrylate monomer
* Methyl methylacrylate
* Methyl alpha-methylacrylate
* Methyl 2-methyl-2-propenoate
* 2-Methyl-2-propenoic acid methyl ester
* Metil metacrilato
* NCI-C50680
* Pegalan
* 2-Propenoic acid, 2-methyl-, methyl ester
* RCRA waste number U162
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 gm/kg
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,343,1941
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 150 mg
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 125 ppm
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - excitement
Behavioral - anorexia (human)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 19(10),25,1954
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 60 mg/m3
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - excitement
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 1,56,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7872 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,343,1941
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 78000 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(6),5,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1328 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 51,1632,1972
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7088 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(4),6,1976
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18500 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(6),5,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 945 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5954 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Mammal - dog
DOSE/DURATION
: 4725 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 41200 mg/m3/3H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4252 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 120 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 63,376,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 7 mL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Kidney, Ureter, Bladder - changes primarily in glomeruli
Biochemical - Metabolism (Intermediary) - porphyrin including bile
pigments
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520933
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(4),6,1976
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 17500 mg/m3/4.5H
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,343,1941
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0544282
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 14 mL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520933
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
5954 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 19000 mg/m3/5H
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,343,1941
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1890 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5954 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 20 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10500 mg/kg/21D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Behavioral - somnolence (general depressed activity)
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
27,121,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17896 mg/kg/35W-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Liver - other changes
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 32,653,1971
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 116 ppm/8H/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in phosphorus
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 11,66,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5000 ppm/6H/14W-I
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis,
etc.)
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-314,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 34500 mg/m3/16W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
Biochemical - Metabolism (Intermediary) - amino acids (including renal
excretion)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(10),74,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/24H/60D-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Metabolism (Intermediary) - porphyrin including bile
pigments
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 27(11),3,1962
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 115 mg/m3/3H/17W-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(1),34,1980
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/6H/2Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 52,237,1988
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
41 gm/m3/90M/15D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5000 ppm/6H/14W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Liver - hepatitis (hepatocellular necrosis), zonal
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-314,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 ppm/6H/2Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 52,237,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 19665 mL/kg/15W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons,
Inc.,
605 Third Ave., New York, NY 10158) V.11967Volume(issue)/page/year:
8,11,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1825 mg/kg/2Y-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
6,29,1964
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 47 gm/m3/90M/15D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 15 gm/m3/7H/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520933
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 97500 ug/kg/39W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(4),6,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15 gm/m3/7H/5D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Metabolism (Intermediary) - porphyrin including bile
pigments
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520933
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 65 gm/m3/3H/3D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 14,292,1945
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 400 ppm/6H/78W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521056
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1620 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CORTBR Clinical Orthopaedics and Related Research. (Lippincott/Harper,
Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)
No.261963- Volume(issue)/page/year: 88,223,1972
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - woman
DOSE
: 10 mg/m3
SEX/DURATION
: female 9 year(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 62(4),19,1997
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
109 gm/m3/17M
female 6-15 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
50,451,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 109 gm/m3/54M
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
50,451,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 54 mg/m3/24H
SEX/DURATION
: female 8 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(2),49,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4480 mg/m3/2H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
31(Suppl),80,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 405 mg/kg
SEX/DURATION
: female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 51,1632,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 801 mg/kg
SEX/DURATION
: female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 51,1632,1972
** MUTATION DATA **
TYPE OF TEST
:
TEST SYSTEM
:
DOSE/DURATION
:
REFERENCE :
JBJSA3 Journal of Bone
St., Boston, MA 02115)
61A,1203,1979
Mutation in microorganisms
Bacteria - Salmonella typhimurium
34 mmol/L
and Joint Surgery, American Volume. (10 Shattuck
V.301948- Volume(issue)/page/year:
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 4 mg/m3/16W
REFERENCE :
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.191966Volume(issue)/page/year: 27(6),102,1974
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2202 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
222,191,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),4,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2799 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,49,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2202 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
222,191,1989
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 704 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-314,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1600 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-314,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1500 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-314,1986
(Research
(Research
(Research
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 410 mg/m3 (100 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 19,187,1979
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 19,187,1979
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 60,445,1994
IARC Cancer Review:Animal LACK CARCINOGENICITY
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 60,445,1994
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 60,445,1994
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,141,1975
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 100 ppm (410 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,168,1971
OSHA PEL (Gen Indu):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 100 ppm (410 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 50 ppm (210 mg/m3), JAN1999
OEL-BELGIUM:TWA 100 ppm (410 mg/m3) JAN 1993
OEL-DENMARK: TWA 50 ppm (205 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 100 ppm (410 mg/m3);STEL 150 ppm (615 mg/m3) JAN 1993
OEL-GERMANY:TWA 50 ppm (210 mg/m3) JAN 1993
OEL-HUNGARY:TWA 50 mg/m3;STEL 150 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (410 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 100 ppm (410 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 50 mg/m3, MAC(STEL) 400 mg/m3, JAN1999
OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
OEL-SWEDEN:TWA 50 ppm (200 mg/m3);STEL 150 ppm (600 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (210 mg/m3);STEL 100 ppm (420 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (410 mg/m3);STEL 125 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL METHACRYLATE-air:10H TWA 100 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 47700
No. of Facilities: 11522 (estimated)
No. of Industries: 89
No. of Occupations: 73
No. of Employees: 89435 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 47700
No. of Facilities: 6757 (estimated)
No. of Industries: 76
No. of Occupations: 80
No. of Employees: 170079 (estimated)
No. of Female Employees: 59519 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Methyl methacrylate, 2537
NTP Carcinogenesis Studies (inhalation);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-314,1986
METHACRYLOXYPROPYL TRIMETHOXYSILANE (GAMMA-)
RTECS NUMBER
: UC0230000
CHEMICAL NAME
: 1-Propanol, 3-(trimethoxysilyl)-, methacrylate
CAS REGISTRY NUMBER
: 2530-85-0
BEILSTEIN REFERENCE NO. : 1952435
LAST UPDATED
: 199710
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C10-H20-O5-Si
MOLECULAR WEIGHT
: 248.39
WISWESSER LINE NOTATION : 1UY1&VO3-SI-O1&O1&O1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Dynasylan MEMO
* KBM 503
* KH 570
* M 8550
* Methacrylic acid, 3-(trimethoxysilyl)propyl ester
* gamma-Methacryloxypropyltrimethoxysilane
* Mops-M
* NUCA 174
* 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester
* Silane, (3-hydroxypropyl)trimethoxy-, methacrylate
* Silicone A-174
* 3-(Trimethoxysilyl)-1-propanol methacrylate
* Trimethoxysilyl-3-propylester kyseliny methakrylove
* Union carbide A-174
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1235,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1235,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 22600 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/9/1967
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 226 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKOGAV Nippon Kokoka Gakkai Zasshi. Journal of the Japanese
Stomatological
Society. (Nippon Kokoka Gakkai, c/o Tokyo Daigaku Igakubu Koko Gekagaku
Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.11952Volume(issue)/page/year: 22,533,1973
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/9/1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 143 mg/m3/6H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0529951
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0118
No. of Facilities: 64 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 966 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0118
No. of Facilities: 2492 (estimated)
No. of Industries: 36
No. of Occupations: 27
No. of Employees: 31238 (estimated)
No. of Female Employees: 7749 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHACRYLOYL CHLORIDE
RTECS NUMBER
: OZ5791000
CHEMICAL NAME
: Methacryloyl chloride
CAS REGISTRY NUMBER
: 920-46-7
BEILSTEIN REFERENCE NO. : 0878175
REFERENCE
: 4-02-00-01537 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C4-H5-Cl-O
MOLECULAR WEIGHT
: 104.54
SYNONYMS/TRADE NAMES :
* Methacryl chloride
* Methacrylic acid chloride
* Methacrylic chloride
* Methacrylyl chloride
* Methylacryloyl chloride
* alpha-Methylacryloyl chloride
* 2-Methylpropenoic acid chloride
* 2-Methylpropenoyl chloride
* 2-Methyl-2-propenoyl chloride
* 2-Propenoyl chloride, 2-methyl*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,80,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - mouse
115 mg/m3/2H
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,80,1982
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHANESULFONIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
PB1140000
Methanesulfonic acid
75-75-2
1446024
4-04-00-00010 (Beilstein Handbook Reference)
199710
11
C-H4-O3-S
96.11
WSQ1
Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* Kyselina methansulfonova
* Methylsulfonic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LC - Lethal concentration
Inhalation
Rodent - rat
>330 ppm/6H
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 48,371,1976
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83577
No. of Facilities: 82 (estimated)
No. of Industries: 3
No. of Occupations: 9
No. of Employees: 1209 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83577
No. of Facilities: 325 (estimated)
No. of Industries: 7
No. of Occupations: 13
No. of Employees: 8084 (estimated)
No. of Female Employees: 1393 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHANESULFONYL CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
PB2790000
Methanesulfonyl chloride
124-63-0
199710
14
C-H3-Cl-O2-S
114.55
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Chloromethyl sulfone
* Mesyl chloride
* Methanesulfonic acid chloride
* Methanesulphonyl chloride
* Methyl sulfochloride
* Methylsulfonyl chloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 620 mg/m3/6H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 uL/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg/2W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - changes in structure or function of esophagus
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571119
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 250 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,165,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 32 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
390,105,1997
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5012
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 851 (estimated)
No. of Female Employees: 187 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHANESULFONYL FLUORIDE
RTECS NUMBER
: PB2975000
CHEMICAL NAME
: Methanesulfonyl fluoride
CAS REGISTRY NUMBER
: 558-25-8
BEILSTEIN REFERENCE NO. : 1740836
REFERENCE
: 4-04-00-00027 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C-H3-F-O2-S
MOLECULAR WEIGHT
: 98.10
WISWESSER LINE NOTATION : WSF1
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* Fluoro methyl sulfone
* Fumette
* Methanesulphonyl fluoride
* Mesyl fluoride
* MSF
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 ppm/7H
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,986,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - rat
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 173,33,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 4,271,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
1,287,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
1,287,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Mammal - dog
5620 ug/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >24 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
1,287,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3370 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppm/7H/13W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,986,1979
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHANOL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
PC1400000
Methanol
67-56-1
54841-71-3
199907
111
C-H4-O
32.05
Q1
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Alcool methylique
* Alcool metilico
* Bieleski's solution
* Carbinol
* Colonial Spirit
* Columbian Spirit
* Metanolo
* Methanol
* Methyl alcohol
* Methylol
* Methylalkohol
* Methyl hydrate
* Methyl hydroxide
* Metylowy alkohol
* Monohydroxymethane
* Pyroxylic Spirit
* RCRA waste number U154
* Wood alcohol
* Wood naphtha
* Wood Spirit
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
20 mg/24H
Moderate
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,187,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 40 mg
REACTION SEVERITY
: Moderate
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/24/1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,187,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 9450 uL/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - general anesthetic
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders,
Philadelphia,
PA) V.11983- Volume(issue)/page/year: 16,538,1998
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 6422 mg/kg
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis,
etc.)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
REFERENCE :
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc.,
POB
8650, Ottawa, ON K1G 0G8, Canada) V.11911Volume(issue)/page/year:
128,14,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Human - man
DOSE/DURATION
: 3429 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
212,5,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 428 mg/kg
TOXIC EFFECTS :
Behavioral - headache
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,74,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 143 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - optic nerve neuropathy
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,382,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
212,5,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 86000 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 300 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - headache
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,74,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 868 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5628 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(11),27,1975
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 64000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,74,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 7529 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 25,271,1982
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,80,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10765 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
9800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1365,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 7 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
Behavioral - coma
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
3,202,1961
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62,
1923-70. For publisher information, see CHMTBL.
Volume(issue)/page/year:
23,931,1931
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Administration onto the skin
: Primate - monkey
DOSE/DURATION
: 393 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62,
1923-70. For publisher information, see CHMTBL.
Volume(issue)/page/year:
23,931,1931
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 44 gm/m3/6H
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 4641 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 16,1,1920
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 14200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 48A,105,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,74,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1826 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8907 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3556 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 8555 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 61,321,1985
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 59 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
V.4-
1898-
Volume(issue)/page/year: 50,296,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 gm/kg/8W-I
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - alteration of operant conditioning
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.91987Volume(issue)/page/year:
15,223,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 mL/kg/7D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Effect on specific coenzyme - B vitamins including folate
REFERENCE :
JDGRAX Journal of Drug Research. (National Organization for Drug
Research
and Control, POB 29, Cairo, Egypt) V.21969Volume(issue)/page/year:
10(1-2),25,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/m3/12H/13W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 24(10),7,1959
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2610 ppm/6H/4W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
11,343,1995
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3846 ug/kg/30D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
9,479,1993
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 mg/kg
SEX/DURATION
: female 17-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 33,259,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35295 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O
Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970Volume(issue)/page/year: 22(1),71,1991
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
Reproductive - Effects
REFERENCE :
TDLo - Lowest published toxic dose
Oral
Rodent - rat
35295 mg/kg
female 1-15 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
on Newborn - biochemical and metabolic
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9.
Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970Volume(issue)/page/year: 22(1),71,1991
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 49,399,1994
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20000 ppm/7H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(2),48A,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20000 ppm/7H
SEX/DURATION
: female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,727,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
10000 ppm/7H
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,727,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 ppm/20H
SEX/DURATION
: male 78 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 14,75,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5200 uL/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
11,503,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 47,175,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
4 gm/kg
female 7 day(s) after conception
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 55,138,1997
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1500 ppm/6H
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 12,101,1992
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5000 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 47,175,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7500 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 47,175,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
2000 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 47,175,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 15000 ppm
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 21,508,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5 gm/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
130,417,1984
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 mg/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 12 pph
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.11960- Volume(issue)/page/year: 37,173,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 56000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
215,187,1989
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 3000 ppm
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 12,72,1974
1963-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 300 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 79,1171,1982
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 umol/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,317,1982
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 7900 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
3),10,1985
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,317,1982
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
ENMUDM Environmental
:
:
:
:
Cytogenetic analysis
Intraperitoneal
Rodent - mouse
75 mg/kg
Mutagenesis.
(New York, NY)
V.1-9, 1979-87.
For
publisher information, see EMMUEG.
Volume(issue)/page/year: 5,381,1983
*** REVIEWS ***
ACGIH TLV-STEL 328 mg/m3 (250 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 262 mg/m3 (200 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
MEDIAV Medicine. (Williams & Wilkins Co., 428 E. Preston St., Baltimore,
MD
21202)
V.1-
1922-
Volume(issue)/page/year: 32,431,1953
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.11955Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For
pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 1,153,1975
TOXICOLOGY REVIEW
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co.
Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.11914Volume(issue)/page/year: 2,483,1978
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 200 ppm (260 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,155,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (260 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 200 ppm (260 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (260 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (260 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 200 ppm (260 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 200 ppm (260 mg/m3), Skin, JAN1999
OEL-AUSTRALIA:TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin JAN 1993
OEL-BELGIUM:TWA 200 ppm (262 mg/m3);STEL 250 ppm;Skin JAN 1993
OEL-DENMARK: TWA 200 ppm (260 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin JAN 1993
OEL-JAPAN: OEL 200 ppm (260 mg/m3), Skin, JAN1999
OEL-GERMANY:TWA 200 ppm (260 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 100 mg/m3, MAC(STEL) 300 mg/m3, JAN1999
OEL-JAPAN:TWA 200 ppm (260 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 200 ppm (260 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 200 ppm (260 mg/m3) JAN 1993
OEL-RUSSIA:TWA 200 ppm;STEL 5 mg/m3;Skin JAN 1993
OEL-SWEDEN:TWA 200 ppm (250 mg/m3);STEL 250 ppm (350 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (260 mg/m3);STEL 400 ppm;Skin JAN 1993
OEL-THAILAND:TWA 200 ppm (260 mg/m3) JAN 1993
OEL-TURKEY:TWA 200 ppm (260 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHANOL-air:10H TWA 200 ppm (Sk);STEL 250 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 45930
No. of Facilities: 78840 (estimated)
No. of Industries: 344
No. of Occupations: 203
No. of Employees: 737242 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 45930
No. of Facilities: 101075 (estimated)
No. of Industries: 373
No. of Occupations: 225
No. of Employees: 1620617 (estimated)
No. of Female Employees: 388352 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell
transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; In vitro
SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8989
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Methanol, 2000
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
METHENAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
MN4725000
Hexamethylenetetramine
100-97-0
74734-16-0
199907
30
C6-H12-N4
140.22
T66 B6 A B- C 1B I BN DN FN HNTJ
Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Aceto HMT
* Aminoform
* Ammoform
* Ammonioformaldehyde
* Cystamin
* Cystogen
* Esametilentetramina
* Formamine
* Formin
* Hexaform
* Hexamethylenamine
* Hexamethyleneamine
* Hexamethylenetetraamine
* Hexamethylentetramin
* Hexamethylentetramine
* Hexilmethylenamine
* HMT
* Methamin
* Methenamine
* Preparation AF
* Resotropin
* 1,3,5,7-Tetraazaadamantane
* 1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 37))decane
* Uritone
* Urotropin
* Urotropine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59
Volume(issue)/page/year: 1,84,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 221,166,1954
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 569 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),115,1970
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 215 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 225,428,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17700 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 20,891,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,84,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,84,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology.
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
(Rapra Technology
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/m3/2H/3W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),115,1970
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 140 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 50A,71,1972
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 mg/plate
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 27,400,1985
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6 mg/well/16H
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
15,219,1976
TYPE OF TEST
TEST SYSTEM
: DNA repair
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 1 mg/disc
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 26,147,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 100 umol/L
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 4,112,1967
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 mmol/L
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 4,112,1967
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 25 gm/kg
REFERENCE :
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.)
V.1-104, 1875-1979. Volume(issue)/page/year: 92,2315,1967
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 25 gm/kg
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 4,112,1967
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 10 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,457,1983
*** REVIEWS ***
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-SWEDEN:TWA 3 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 4 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 33675
No. of Facilities: 3087 (estimated)
No. of Industries: 49
No. of Occupations: 59
No. of Employees: 30437 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 33675
No. of Facilities: 9101 (estimated)
No. of Industries: 81
No. of Occupations: 86
No. of Employees: 188300 (estimated)
No. of Female Employees: 40283 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHIONINE (D-)
RTECS NUMBER
: PD0455000
CHEMICAL NAME
: Methionine, DCAS REGISTRY NUMBER
: 348-67-4
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C5-H11-N-O2-S
MOLECULAR WEIGHT
: 149.23
WISWESSER LINE NOTATION : QVYZ2S1 -D
SYNONYMS/TRADE NAMES :
* D-Methionine
* (R)-Methionine
* D-Metionien (Australian)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5223 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.311951- Volume(issue)/page/year:
64,319,1956
*** REVIEWS ***
TOXICOLOGY REVIEW
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 22,2,1974
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHIONINE (DL-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
PD0456000
Methionine, DL59-51-8
199706
14
C5-H11-N-O2-S
149.23
QV1YZ1S1
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acimetion
* Banthionine
* Cynaron
* Dyprin
* Lobamine
* Meonine
* Methilanin
* (+-)-Methionine
* DL-Methionine
* Metione
* Mertionin
* Neston
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 5,2041,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36 gm/kg/30D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in leukocyte (WBC) count
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 79,101,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21 gm/kg/13D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 106,1714,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 39 gm/kg/20D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 106,1714,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - turkey
DOSE/DURATION
: 33600 mg/kg/4W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St.,
Champaign, IL 61820) V.11921- Volume(issue)/page/year: 57,699,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 gm/kg
SEX/DURATION
: female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 33,109,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3271
No. of Facilities: 1272 (estimated)
No. of Industries: 5
No. of Occupations: 27
No. of Employees: 16781 (estimated)
No. of Female Employees: 4397 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHIONINE SOLUTION (L-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
PD0457000
Methionine, L63-68-3
7005-18-7
24425-78-3
199903
24
C5-H11-N-O2-S
149.23
QVYZ2S1 -L
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* L-alpha-Amino-gamma-methylmercaptobutyric acid
* (S)-2-Amino-4-(methylthio)butanoic acid
* L(-)-Amino-gamma-methylthiobutyric acid
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
L-alpha-Amino-gamma-methylthiobutyric acid
2-Amino-4-methylthiobutanoic acid
2-Amino-4-(methylthio)butyric acid
Butyric acid, 2-amino-4-(methylthio)Butanoic acid, 2-amino-4-(methylthio)-, (S)Cymethion
L-Homocysteine, S-methylLactet
Liquimeth
Methionine
L-Methionine
1-Methionine
L-(-)-Methionine
S-Methionine
gamma-Methylthio-alpha-aminobutyric acid
L-gamma-Methylthio-alpha-aminobutyric acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Immunological Including Allergic - uncharacterized
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 48(6),20,1983
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4328 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.311951- Volume(issue)/page/year:
58,253,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >9500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,682,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21600 mg/kg/60D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - leukopenia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 48(6),20,1983
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 26100 mg/kg
SEX/DURATION
: female 10-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 82,457,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 14720 mg/kg
SEX/DURATION
: female 10-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 82,457,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
35 gm/kg
female 2 week(s) pre-mating
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 46,499,1992
V.1-
1968-
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,376,1981
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 200 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,224,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 500 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,502,1981
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 2 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
696,15,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 125 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,517,1981
TYPE OF TEST
TEST SYSTEM
: Sister chromatid exchange
: Human Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
372,75,1996
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
696,15,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - guinea pig
DOSE/DURATION
: 500 mg/kg
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York
Ave.,
New York, NY 10003) V.121962- Volume(issue)/page/year: 47,190a,1970
*** REVIEWS ***
TOXICOLOGY REVIEW
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 22,2,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81891
No. of Facilities: 273 (estimated)
No. of Industries: 5
No. of Occupations: 17
No. of Employees: 12017 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81891
No. of Facilities: 1116 (estimated)
No. of Industries: 4
No. of Occupations: 18
No. of Employees: 28520 (estimated)
No. of Female Employees: 17038 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHIONINE SULFOXIDE (DL-)
RTECS NUMBER
: ES7120000
CHEMICAL NAME
: Butyric acid, 2-amino-4-(methylsulfinyl)CAS REGISTRY NUMBER
: 454-41-1
BEILSTEIN REFERENCE NO. : 1723794
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C5-H11-N-O3-S
MOLECULAR WEIGHT
: 165.23
WISWESSER LINE NOTATION : QVYZ2SO&1
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* 2-Amino-4-(methylsulfinyl)butyric acid
* 2-Amino-4-(methylsulfinyl)butanoic acid
* Butanoic acid, 2-amino-4-(methylsulfinyl)* Methionine sulfoxide
* dl-Methionine sulfoxide
* DL-Methionine sulfoxide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJRBA3 International Journal of Radiation Biology and Related Studies in
Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St.,
Philadelphia, PA 19106) V.11959- Volume(issue)/page/year:
3,41,1961
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
3500 mg/kg
female 9-15 day(s) after conception
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ASMUAA Acta Scholae Medicinalis Universitatis in Kioto. (Kyoto, Japan)
V.27-40, 1947-70. Discontinued. Volume(issue)/page/year: 38,193,1962
METHOXYACETIC ACID
RTECS NUMBER
: AI8650000
CHEMICAL NAME
: Acetic acid, methoxyCAS REGISTRY NUMBER
: 625-45-6
BEILSTEIN REFERENCE NO. : 0635800
REFERENCE
: 4-03-00-00574 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C3-H6-O3
MOLECULAR WEIGHT
: 90.09
COMPOUND DESCRIPTOR
: Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Methoxyacetic acid
* 2-Methoxyacetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 2,158,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 2,158,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1280 mg/kg/4D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 109,67,1996
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2368 mg/kg
SEX/DURATION
: male 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
69,385,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(2),54A,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 118 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 43,17,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
592 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,141,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 592 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
32,73,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 225 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
22,93,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 901 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
HIJMAC Hiroshima Journal of Medical Sciences. (Hiroshima University
Medical
Press, c/o Hiroshima University, School of Medicine, 1-2-3 Kasumi,
Minami-ku, Hiroshima, 734, Japan) V.11951Volume(issue)/page/year:
40,93,1991
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 25 mmol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
45,111,1989
*** REVIEWS ***
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,747,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHOXYACETOPHENONE (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
AM9240000
Acetophenone, 4'-methoxy100-06-1
199701
9
C9-H10-O2
150.19
1VR DO1
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetanisole
* p-Acetylanisole
* 4-Acetylanisole
* Ethanone, 1-(4-methoxyphenyl)* Linarodin
* 4-Methoxyacetofenon
* p-Methoxyacetophenone
* 4-Methoxyacetophenone
* 4'-Methoxyacetophenone
* 1-(4-Methoxyphenyl)ethanone
* p-Methoxyphenyl methyl ketone
* 4-Methoxyphenyl methyl ketone
* Novatone
* Vananote
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,927,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1700 ug/m3/39W-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(4),86,1985
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,927,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 820 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - irritability
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(4),86,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
(V/O
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,927,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 152 mg/m3/4H/13W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(4),86,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83215
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 580 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83215
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 1557 (estimated)
No. of Female Employees: 276 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYAMINE HYDROCHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
NC3980000
Hydroxylamine, O-methyl-, hydrochloride
593-56-6
199701
11
C-H5-N-O.Cl-H
83.53
ZO1 &GH
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Methoxyamine, hydrochloride
* Methoxylamine hydrochloride
* Methyloxyammonium chloride
* O-Methylhydroxylamine hydrochloride
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 900 mmol/L
REFERENCE :
DKBSAS Doklady Biological Sciences (English Translation). Translation of
DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York,
NY
10013) V.1121957- Volume(issue)/page/year: 257,154,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
390,1,1975
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
49,163,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
49,173,1978
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
2,331,1970
TYPE OF TEST
TEST SYSTEM
: Cytogenetic analysis
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 2 gm/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
11,480,1975
(Plenum Pub.
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 gm/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
11,475,1975
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 2 gm/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
9,1525,1973
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYBENZALDEHYDE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
BZ2610000
o-Anisaldehyde
135-02-4
0606301
4-08-00-00180 (Beilstein Handbook Reference)
199710
8
C8-H8-O2
136.16
VHR BO1
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2-Anisaldehyde
* Benzaldehyde, 2-methoxy-
*
*
*
*
*
o-Methoxybenzaldehyde
2-Methoxybenzaldehyde
6-Methoxybenzaldehyde
2-Methoxybenzenecarboxaldehyde
Salicylaldehyde methyl ether
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,855,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,855,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533625
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,855,1979
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 125 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHOXYBENZALDEHYDE (3-)
RTECS NUMBER
: BZ2605000
CHEMICAL NAME
: m-Anisaldehyde
CAS REGISTRY NUMBER
: 591-31-1
BEILSTEIN REFERENCE NO. : 0606013
REFERENCE
: 4-08-00-00241 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H8-O2
MOLECULAR WEIGHT
: 136.16
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzaldehyde, 3-methoxy* m-Methoxybenzaldehyde
* 3-Methoxybenzaldehyde
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYBENZAMIDE (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* p-Anisamide
* p-Methoxybenzamide
* 4-Methoxybenzamide
:
:
:
:
:
:
:
:
:
:
CV5466666
Benzamide, 4-methoxy3424-93-9
1862847
4-10-00-00433 (Beilstein Handbook Reference)
199612
1
C8-H9-N-O2
151.18
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 28,335,1994
METHOXYBENZENESULFONAMIDE (4-)
RTECS NUMBER
: DB2900000
CHEMICAL NAME
: Benzenesulfonamide, 4-methoxyCAS REGISTRY NUMBER
: 1129-26-6
BEILSTEIN REFERENCE NO. : 2047881
REFERENCE
: 4-11-00-00588 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H9-N-O3-S
MOLECULAR WEIGHT
: 187.23
SYNONYMS/TRADE NAMES :
* Benzenesulfonamide, p-methoxy* p-Methoxybenzenesulfonamide
* 4-Methoxybenzenesulfonamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
No.1-
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 8,548,1965
METHOXYBENZOIC ACID (3-)
RTECS NUMBER
: BZ4375000
CHEMICAL NAME
: m-Anisic acid
CAS REGISTRY NUMBER
: 586-38-9
BEILSTEIN REFERENCE NO. : 0508838
REFERENCE
: 4-10-00-00316 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H8-O3
MOLECULAR WEIGHT
: 152.16
WISWESSER LINE NOTATION : QVR CO1
SYNONYMS/TRADE NAMES :
* 3-Anisic acid
* Benzoic acid, 3-methoxy* m-Methoxybenzoic acid
* 3-Methoxybenzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 6,144,1954
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYBENZOPHENONE (4-)
RTECS NUMBER
: PC4962500
CHEMICAL NAME
: Methanone, (4-methoxyphenyl)phenylCAS REGISTRY NUMBER
: 611-94-9
LAST UPDATED
: 199706
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C14-H12-O2
MOLECULAR WEIGHT
: 212.26
SYNONYMS/TRADE NAMES :
* Benzophenone, 4-methoxy* p-Methoxybenzophenone
* 4-Methoxybenzophenone
* p-Methoxybenzyl phenyl ketone
* (4-Methoxyphenyl)phenylmethanone
* Phenyl p-anisyl ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (3),46,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3673 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (3),46,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3039 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (3),46,1994
METHOXYBENZYL ALCOHOL (4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
DO8925000
Benzyl alcohol, p-methoxy105-13-5
0636654
4-06-00-05909 (Beilstein Handbook Reference)
199701
8
C8-H10-O2
138.18
Q1R DO1
Agricultural Chemical
Primary Irritant
SYNONYMS/TRADE NAMES :
* Anise alcohol
* Anisic alcohol
* p-Anisol alcohol
* Anisyl alcohol
* 4-Methoxybenzenemethanol
* p-Methoxybenzyl alcohol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,825,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >10 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,825,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 90 mL/kg/13W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84679
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 19
No. of Employees: 2073 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
1909/10-
METHOXYBENZYLAMINE (3-)
RTECS NUMBER
: DP5550000
CHEMICAL NAME
: Benzylamine, m-methoxyCAS REGISTRY NUMBER
: 5071-96-5
BEILSTEIN REFERENCE NO. : 1447182
REFERENCE
: 4-13-00-01704 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C8-H11-N-O
MOLECULAR WEIGHT
: 137.20
WISWESSER LINE NOTATION : Z1R CO1
SYNONYMS/TRADE NAMES :
* Benzenemethanamine, 3-methoxy* m-Methoxybenzylamine
* 3-Methoxybenzylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#08724
METHOXYBENZYLIDENE BUTYLANILINE (N,4,4-)
RTECS NUMBER
: BW9550000
CHEMICAL NAME
: Aniline, p-butyl-N-(p-methoxybenzylidene)CAS REGISTRY NUMBER
: 26227-73-6
BEILSTEIN REFERENCE NO. : 0790714
LAST UPDATED
: 199812
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C18-H21-N-O
MOLECULAR WEIGHT
: 267.40
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzeneamine, 4-butyl-N-((4-methoxyphenyl)methylene)* DL 1047 N
* MBBA
* 4-Methoxybenzylidene-4'-n-butylaniline
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 33 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11(Suppl 12),1,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYCHLOR
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KJ3675000
Ethane, 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)72-43-5
2057367
4-06-00-06691 (Beilstein Handbook Reference)
199907
84
C16-H15-Cl3-O2
345.66
GXGGYR DO1&R DO1
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxy* 2,2-Bis(p-anisyl)-1,1,1-trichloroethane
* 1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane
* 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane
* Dianisyltrichlorethane
* 2,2-Di-p-anisyl-1,1,1-trichloroethane
* Dimethoxy-DDT
* p,p'-Dimethoxydiphenyltrichloroethane
* 2,2-Di-(p-methoxyphenyl)-1,1,1-trichloroethane
* Di(p-methoxyphenyl)-trichloromethyl methane
* DMDT
* p,p'-Dwumetoksydwufenylotrojchloroetan
* ENT 1,716
* Ethane, 2,2-bis(p-anisyl)-1,1,1-trichloro* Higalmetox
* Marlate
* Methoxcide
* Methoxychlor
* p,p'-Methoxychlor
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Methoxychlor 2 EC
Methoxy-DDT
Metoksychlor
Metox
Mezox K
Moxie
NCI-C00497
OMS 466
RCRA waste number U247
1,1,1-Trichlor-2,2-bis(4-methoxy-phenyl)-aethan
1,1,1-Trichloro-2,2-bis(p-anisyl)ethane
1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene)
1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane
1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane
2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane
1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane
4,4-(2,2,2-Trichloroethylidene)dianisole
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 6430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,705,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2414 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,705,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1855 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
(V/O
Volume(issue)/page/year: 58(1),44,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 510 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(1),44,1993
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,16,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 3,28,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.)
58,152,1986
V.32-
1974-
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
9,574,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 266 mg/kg/19W-I
TOXIC EFFECTS :
Liver - other changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(10),82,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 602 mg/kg/43W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(1),44,1993
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - prostate tumors
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 36,205,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56700 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology.
(Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)
1979- Volume(issue)/page/year: 93,173,1979
V.93-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 383 gm/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 36,205,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 41 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - multiple effects
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
11,88,1967
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 62622 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 36,205,1980
TYPE OF TEST
ROUTE OF EXPOSURE
: TD - Toxic dose (other than lowest)
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 80 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
24,1367,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 72800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 36,205,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 87360 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 36,205,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10920 mg/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 83,491,1950
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45500 mg/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
V.4-
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 83,491,1950
V.4-
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 66 gm/kg
SEX/DURATION
: male 33 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.11909/10Volume(issue)/page/year: 138,126,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
45,435,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
45,435,1978
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4250 mg/kg
SEX/DURATION
: female 42 day(s) pre-mating - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Effects on Newborn - physical
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 22,969,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10625 mg/kg
SEX/DURATION
: female 42 day(s) pre-mating - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 22,969,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7 gm/kg
SEX/DURATION
: male 70 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
AHEMA5 Anatomia, Histologia, Embryologia. (Paul Parey Scientific Pub.,
35
W. 38th St., Suite 3W, New York, NY 10018) V.21973Volume(issue)/page/year: 9,89,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2100 mg/kg
SEX/DURATION
: female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
AHEMA5 Anatomia, Histologia, Embryologia.
(Paul Parey Scientific Pub.,
35
W. 38th St., Suite 3W, New York, NY 10018)
Volume(issue)/page/year: 9,89,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
V.2-
1973-
TDLo - Lowest published toxic dose
Unreported
Rodent - rat
9100 mg/kg
male 70 day(s) pre-mating
female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
AHEMA5 Anatomia, Histologia, Embryologia. (Paul Parey Scientific Pub.,
35
W. 38th St., Suite 3W, New York, NY 10018) V.21973Volume(issue)/page/year: 9,89,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 gm/kg
SEX/DURATION
: female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
5,139,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 900 mg/kg
SEX/DURATION
: female 6-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
6,431,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987-
Volume(issue)/page/year:
6,431,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
6,431,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 800 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
11,703,1997
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 150 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,181,1994
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 28 gm/kg/10W (Continuous)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 176,187,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in microorganisms
: Rodent - mouse Lymphocyte
: 10 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 2 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,1303,1981
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg/50D (Intermittent)
REFERENCE :
FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw
Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.11929Volume(issue)/page/year: 35,361,1976
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
356,85,1996
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 50 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
58,152,1986
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,259,1979
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,259,1979
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,152,1971
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 15 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 15 mg/m3, JAN1999
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-DENMARK: TWA 5 mg/m3, JAN1999
OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL-GERMANY:TWA 15 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 15 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 15 mg/m3, MAC(STEL) 45 mg/m3, JAN1999
OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993
OEL-THAILAND:TWA 15 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHOXYCHLOR-air:CA (0.07 mg/m3 LOQ)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46210
No. of Facilities: 248 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 638 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46210
No. of Facilities: 504 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 3417 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell
transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; SHE-clonal
assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP
reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA
without S9
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-35,1978
METHOXYCINNAMIC ACID (4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
UD3391300
2-Propenoic acid, 3-(4-methoxyphenyl)830-09-1
199701
2
C10-H10-O3
178.20
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 3-(4-Methoxyphenyl)-2-propenoic acid
* 4-Methoxycinnamic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1300 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
REFERENCE :
IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz
(East), Bombay 400 029, India) V.40(2)1978Volume(issue)/page/year:
49,77,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYCINNAMIC ACID (4-)
RTECS NUMBER
: OL5987000
CHEMICAL NAME
: Lysozyme
CAS REGISTRY NUMBER
: 9001-63-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* N,O-Diacetylmuramidase
* E.C. 3.2.1.17
* Globulin G
* Globulin G1
* Lysozyme G
* Mucopeptide glucohydrolase
* Muramidase
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
>2 gm/kg
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 21,587,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5800 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 21,587,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4756
No. of Facilities: 54 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 2826 (estimated)
No. of Female Employees: 1755 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYCINNAMIC ACID (CIS,2-)
RTECS NUMBER
: GD9720000
CHEMICAL NAME
: Cinnamic acid, o-methoxy-, (Z)CAS REGISTRY NUMBER
: 14737-91-8
BEILSTEIN REFERENCE NO. : 2209713
REFERENCE
: 4-10-00-00999 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C10-H10-O3
MOLECULAR WEIGHT
: 178.20
WISWESSER LINE NOTATION : QV1U1R BO1 -C
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acide ortho-methoxycinnamique
* cis-o-Methoxycinnamic acid
* cis-2-Methoxycinnamic acid
* (Z)-3-(2-Methoxyphenyl)-2-propenoic acid
* 2-Propenoic acid, 3-(2-methoxyphenyl)-, (Z)-
* Substance H 36
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 119,443,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 119,443,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 119,443,1959
METHOXYETHANOL (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
:
:
KL5775000
Ethanol, 2-methoxy109-86-4
1731074
4-01-00-02375 (Beilstein Handbook Reference)
199907
118
C3-H8-O2
76.11
Q2O1
V.4-
V.4-
V.4-
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aethylenglykol-monomethylaether
* Dowanol 7
* Dowanol EM
* Ether monomethylique de l'ethylene-glycol
* Ethylene glycol methyl ether
* Glycol ether EM
* Glycolmethyl ether
* Glycol monomethyl ether
* Jeffersol EM
* 2-Methoxy-aethanol
* Methoxyethanol
* 2-Methoxyethanol
* Methoxyhydroxyethane
* Methyl cellosolve
* Methylcelosolv
* Methyl ethoxol
* Methyl glycol
* Methylglykol
* Methyl oxitol
* Metil cellosolve
* Metoksyetylowy alkohol
* 2-Metossietanolo
* Monomethyl ether of ethylene glycol
* Poly-Solv EM
* Prist
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 483 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,276,1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 97 mg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,276,1971
TYPE OF TEST
ROUTE OF EXPOSURE
: Standard Draize test
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,623,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10 ug
REACTION SEVERITY
: Mild
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 11,150,1959
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 3380 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,267,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 25 ppm
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 20,134,1938
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2370 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary
and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.191977- Volume(issue)/page/year:
29,361,1987
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,57,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,57,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2068 mg/kg
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,114,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2560 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
Cardiac - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(3),48,1988
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1480 ppm/7H
TOXIC EFFECTS :
Behavioral - analgesia
Lungs, Thorax, or Respiration - dyspnea
Kidney, Ureter, Bladder - hematuria
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,157,1943
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2147 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Blood - changes in spleen
Blood - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 6,342,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 890 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Blood - other hemolysis with or without anemia
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,114,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,57,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - general
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
950 mg/kg
anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppm/6H/2W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 22,423,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10206 mg/kg/21D-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16,830,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Immunological Including Allergic - decreased immune response
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
109,494,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 ppm/6H/13W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 3,49,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 970 mg/m3/7H/5W-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in spleen
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,374,1943
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/6H/11D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in leukocyte (WBC) count
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
61,368,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Blood - changes in
Blood - changes in
Related to Chronic
REFERENCE :
TXCYAC Toxicology.
Limerick, Ireland)
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - rat
20 gm/kg/4W-I
other cell count (unspecified)
leukocyte (WBC) count
Data - changes in testicular weight
(Elsevier Scientific Pub. Ireland, Ltd., POB 85,
V.11973- Volume(issue)/page/year: 57,209,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 450 mg/kg/16D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
9,617,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
29484 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - changes in platelet count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3349
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg/4D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 98,215,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12110 mg/kg/2W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3349
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 82 gm/kg/13W-C
TOXIC EFFECTS :
Endocrine - effect on menstrual cycle
Endocrine - other changes
Blood - changes in spleen
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3349
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1000 ppm/6H/11D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
61,368,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Mammal - dog
DOSE/DURATION
: 750 ppm/7H/12W-I
TOXIC EFFECTS :
Blood - microcytosis with or without anemia
Blood - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,409,1943
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 300 ppm/6H/13W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 3,49,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 65 gm/kg/13W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 6,339,1986
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 175 mg/kg
SEX/DURATION
: female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,33,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
175 mg/kg
female 7-13 day(s) after conception
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 9,1,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 15015 mg/kg
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3349
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
69,385,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 350 mg/kg
SEX/DURATION
: female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
86,197,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 68 mg/kg/4H
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active
Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.11966Volume(issue)/page/year: 21,30,1989
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 ppm/6H
SEX/DURATION
: male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 3,49,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 ppm/6H
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
69,43,1983
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
100 ppm/6H
female 6-17 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
69,43,1983
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 ppm/6H
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 3,80,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 11592 mg/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 6,165,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4375 mg/kg
SEX/DURATION
: male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
100,145,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 15,448,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 15,448,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 330 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(2),54A,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 190 mg/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 4,35,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 190 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 4,35,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 190 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 4,35,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 600 mg/kg
SEX/DURATION
: female 6-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 57,199,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 440 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,73,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
250 mg/kg
female 13 day(s) after conception
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
145,415,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 175 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 31,48A,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 gm/kg
SEX/DURATION
: female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 20,335,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
80,108,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 250 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
80,108,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6250 mg/kg
SEX/DURATION
: male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 21,29,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1000 ppm/6H
SEX/DURATION
: male 11 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
61,368,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 ppm/7H
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
70,303,1983
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
75,409,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 57,7,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1200 mg/kg
SEX/DURATION
: female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
50,263,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3200 mg/kg
SEX/DURATION
: female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
50,263,1990
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
250 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 54,219,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 250 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 12,101,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 930 mg/kg
SEX/DURATION
: female 20-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,66A,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 633 mg/kg
SEX/DURATION
: female 20-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,66A,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rabbit
300 ppm/6H
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 3,49,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 50 ppm/6H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
75,409,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 50 ppm/6H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 57,7,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 10 ppm/6H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
75,409,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - guinea pig
6250 mg/kg
SEX/DURATION
: male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 57,75,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 65 gm/kg
SEX/DURATION
: male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 6,339,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 1562 mg/kg
SEX/DURATION
: male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 57,75,1984
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 150 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,125,1994
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,390,1984
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,390,1984
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,390,1984
*** REVIEWS ***
ACGIH TLV-TWA 16 mg/m3 (5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,747,1989
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 25 ppm (80 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,158,1971
OSHA PEL (Gen Indu):8H TWA 25 ppm (80 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 25 ppm (80 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 25 ppm (80 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 25 ppm (80 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (16 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 5 ppm (15 mg/m3), Skin, JAN1999
OEL-BELGIUM:TWA 5 ppm (16 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 5 ppm (16 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 25 ppm (80 mg/m3);STEL 40 ppm (120 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993
OEL-JAPAN: OEL 5 ppm (16 mg/m3), Skin, JAN1999
OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 5 ppm (16 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (16 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 15 mg/m3, MAC(STEL) 60 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 25 ppm (80 mg/m3);Skin JAN 1993
OEL-RUSSIA:TWA 5 ppm JAN 1993
OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993
OEL-TURKEY:TWA 25 ppm (80 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (16 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHYLENEGLYCOL MONOMETHYL ETHER-air:10H TWA 0.1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46240
No. of Facilities: 11165 (estimated)
No. of Industries: 128
No. of Occupations: 102
No. of Employees: 103424 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46240
No. of Facilities: 8042 (estimated)
No. of Industries: 89
No. of Occupations: 86
No. of Employees: 168180 (estimated)
No. of Female Employees: 53403 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9101
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN, #39
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NTP Toxicity studies, RPT# TOX-26, May 1999
OSHA ANALYTICAL METHOD #53
METHOXYETHYL ETHER (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
KN3339000
Ether, bis(2-methoxyethyl)
111-96-6
1736101
4-01-00-02393 (Beilstein Handbook Reference)
199806
20
C6-H14-O3
134.20
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bis(2-methoxyethyl)ether
* Diethylene glycol dimethyl ether
* Diethyl glycol dimethyl ether
* Diglyme
* Ethane, 1,1'-oxybis(2-methoxy* Glyme 2
* Methyldiglyme
* 1,1'-Oxybis(2-methoxyethane)
* Poly-Solv
* 2,5,8-Trioxanonane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (1),27,1996
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (1),27,1996
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16(3),567,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 13680 mg/kg
SEX/DURATION
: male 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
5,1099,1989
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1100 ppm/6H
SEX/DURATION
: male 2 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 59,239,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 537 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,321,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB86-135233
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB86-135233
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB86-135233
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1250 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB86-135233
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1400 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 19,238,1992
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Sex chromosome loss and nondisjunction
: Inhalation
: Insect - Drosophila melanogaster
DOSE/DURATION
: 250 ppm/165M
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-138198
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1000 ppm/5D (Continuous)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-138198
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1000 ppm/5D (Continuous)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-138198
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0698
No. of Facilities: 27 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 191 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0698
No. of Facilities: 13 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 207 (estimated)
No. of Female Employees: 52 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0693-9068
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHOXYETHYLAMINE (2-)
RTECS NUMBER
: KR8750000
CHEMICAL NAME
: Ethylamine, 2-methoxyCAS REGISTRY NUMBER
: 109-85-3
BEILSTEIN REFERENCE NO. : 0741854
REFERENCE
: 4-04-00-01411 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C3-H9-N-O
MOLECULAR WEIGHT
: 75.13
WISWESSER LINE NOTATION : Z2O1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 2-Aminoethyl methyl ether
* Ethanamine, 2-methoxy* 2-Methoxyethanamine
* beta-Methoxyethylamine
* 2-Methoxyethylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 uL/24H
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546426
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546426
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546426
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHOXYINDOLE (5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Methoxy-5 indole
* 5-Methoxyindole
:
:
:
:
:
:
:
:
:
NL9500000
Indole, 5-methoxy1006-94-6
199109
1
C9-H9-N-O
147.19
T56 BMJ GO1
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.91974- Volume(issue)/page/year: 9,453,1974
METHOXYINDOLECARBOXYLIC ACID (5,2-)
RTECS NUMBER
: NL6005000
CHEMICAL NAME
: Indole-2-carboxylic acid, 5-methoxyCAS REGISTRY NUMBER
: 4382-54-1
LAST UPDATED
: 199109
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C10-H9-N-O3
MOLECULAR WEIGHT
: 191.20
WISWESSER LINE NOTATION : T56 BMJ CVQ GO1
SYNONYMS/TRADE NAMES :
* Acide methoxy-5 indole carboxylique-2
* 5-Methoxy-2-indolecarboxylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.91974- Volume(issue)/page/year: 9,453,1974
METHOXYPHENOL (3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
SL7524000
Phenol, m-methoxy150-19-6
199701
15
C7-H8-O2
124.15
QR CO1
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* m-Guaiacol
* m-Hydroxyanisole
* 3-Hydroxyanisole
* m-Methoxyphenol
* 3-Methoxyphenol
* Phenol, 3-methoxy* Resorcinol methyl ether
* Resorcinol monomethyl ether
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5%
REACTION SEVERITY
: Severe
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 46,185,1957
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 230 ug/m3/22W
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - headache
Behavioral - irritability
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 597 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11500 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,105,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 682 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
(V/O
(V/O
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 312 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
(V/O
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11500 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,105,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 46,185,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 597 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(10),16,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Mammal - species unspecified
(V/O
DOSE/DURATION
: 682 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(10),16,1980
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2120 ug/m3/5H/19W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 6200 ug/m3/5H/19W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - woman
DOSE
: 230 ug/m3
SEX/DURATION
: female 22 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(3),108,1972
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
weight
gain)
TDLo - Lowest published toxic dose
Oral
Rodent - rat
333 mg/kg
female 11 day(s) after conception
on Newborn - growth statistics (e.g.%, reduced
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 41,43,1990
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHOXYPHENOL (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
SL7700000
Phenol, p-methoxy150-76-5
199907
21
C7-H8-O2
124.15
QR DO1
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* P-Guaiacol
* Hydroquinone monomethyl ether
* Hydroxyanisole
* p-Hydroxyanisole
* 4-Hydroxyanisole
* p-Hydroxymethoxybenzene
* Leucobasal
* Leucodine B
* Mechinolum
* Mequinol
* p-Methoxyphenol
* 4-Methoxyphenol
* Mono methyl ether hydroquinone
* Novo-Dermoquinona
* PMF (antioxidant)
* USAF AN-7
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6 gm/12D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,79,1949
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7508 ng/kg/12D-I
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
45,935,1982
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 25 umol/L
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 54,133,1986
*** REVIEWS ***
ACGIH TLV-TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(5),31,1985
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg/m3 JAN 1993
OEL-DENMARK: TWA 5 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 4-METHOXYPHENOL-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3672
No. of Facilities: 9805 (estimated)
No. of Industries: 136
No. of Occupations: 89
No. of Employees: 250087 (estimated)
No. of Female Employees: 49763 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8789;8EHQ-0892-8802
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8825
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHOXYPHENYLACETIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
(4-)
: AI8960000
: Acetic acid, p-methoxyphenyl: 104-01-8
: 1101737
: 4-10-00-00544 (Beilstein Handbook Reference)
: 199710
: 7
: C9-H10-O3
: 166.19
: QV1R DO1
: Agricultural Chemical
Tumorigen
Drug
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2-(p-Anisyl)acetic acid
* Anisyl formate
* Benzeneacetic acid, 4-methoxy* Homoanisic acid
* 4-Methoxybenzeneacetic acid
* p-Methoxybenzyl formate
* p-Methoxyphenylacetic acid
* 4-Methoxyphenylacetic acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0530656-1
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,685,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 20,709,1977
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 63 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83216
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 373 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHOXYPHENYLBORONIC ACID (4-)
RTECS NUMBER
: CY8975000
CHEMICAL NAME
: Benzeneboronic acid, p-methoxyCAS REGISTRY NUMBER
: 5720-07-0
BEILSTEIN REFERENCE NO. : 2936912
REFERENCE
: 4-16-00-01681 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H9-B-O3
MOLECULAR WEIGHT
: 151.97
WISWESSER LINE NOTATION : QBQR DO1
SYNONYMS/TRADE NAMES :
* p-Anisylboronic acid
* Boronic acid, p-methoxyphenyl* Boronic acid, (4-methoxyphenyl)* p-Methoxybenzeneboronic acid
* 4-Methoxybenzeneboronic acid
* p-Methoxyphenylboronic acid
* 4-Methoxyphenylboronic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00062
METHOXYPHENYLTHIOUREA (4-)
RTECS NUMBER
: YT6825000
CHEMICAL NAME
: Urea, 1-(p-methoxyphenyl)-2-thioCAS REGISTRY NUMBER
: 2293-07-4
LAST UPDATED
: 199206
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H10-N2-O-S
MOLECULAR WEIGHT
: 182.26
WISWESSER LINE NOTATION : SUYZMR DO1
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* N-p-Anisylthiourea
* p-Anisylthiourea
* 4-Methoxyphenyl thiourea
* (4-Methoxyphenyl)thiourea
* N-(4-Methoxyphenyl)thiourea
* Thiourea, (4-methoxyphenyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Rodent - rat
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,46,1953
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 14,111,1985
METHOXYPSORALEN (5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
LV1300000
7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy484-20-8
0019560
5-19-06-00004 (Beilstein Handbook Reference)
199612
12
C12-H8-O4
216.20
T C566 DO LVOJ HO1
Tumorigen
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Bergaptan
* Bergapten
* Bergaptene
* Heraclin
* 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone
* Majudin
* 5-Methoxy-6,7-furanocoumarin
* 4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
* 5-Methoxypsoralen
* 5-Mop
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: >30 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 204 gm/kg/52W-I
TOXIC EFFECTS :
Behavioral - fluid intake
Endocrine - evidence of thyroid hyperfunction
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 800 mg/kg/8D-I
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - food intake (animal)
Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4368 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5600 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6720 mg/kg
SEX/DURATION
: female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 900 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
25,302,1995
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,242,1987
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 40,327,1986
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,242,1987
METHOXYPSORALEN (8-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
:
LV1400000
7H-Furo(3,2-g)(1)benzopyran-7-one, 9-methoxy298-81-7
12692-94-3
0196453
5-19-06-00015 (Beilstein Handbook Reference)
199904
40
C12-H8-O4
216.20
T C566 DO LVOJ BO1
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ammoidin
* 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
* Geroxalen
* 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone
* Meladinin
* Meladinine
* Meloxine
* Methoxa-dome
* Methoxsalen
* 8-Methoxy-(furano-3'.2':6.7-coumarin)
* 9-Methoxy-7H-furo(3,2-g)benzopyran-7-one
* 8-Methoxy-2',3',6,7-furocoumarin
* 8-Methoxy-4',5',6,7-furocoumarin
* 8-Methoxypsoralen
* 9-Methoxypsoralen
*
*
*
*
*
*
*
*
*
8-Methoxypsoralene
New-meladinin
8-Mop
8-MP
NCI-C55903
Oxsoralen
Oxypsoralen
Proralone-mop
Xanthotoxin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 791 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 2,309,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 158 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 2,309,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1880 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1372,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 423 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
REFERENCE :
DCTODJ Drug and Chemical Toxicology.
(Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.1-
1977/78-
Volume(issue)/page/year: 2,309,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 2,309,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,837,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 505 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
International Symposium, Paris, 1981," Cahn, J., et al., eds., Paris,
Pergamon Press France, 1981 Volume(issue)/page/year: -,303,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26 gm/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-359,1989
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-359,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 690 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Liver - hepatitis (hepatocellular necrosis), zonal
Blood - hemorrhage
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Research
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 131,394,1961
V.1-
1909/10-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1404 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 12,21,1989
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18025 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-359,1989
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
800 mg/kg
female 6-15 day(s) after conception
(Research
Reproductive - Maternal Effects - other effects
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB92-219666
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1600 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB92-219666
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1600 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB92-219666
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 600 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,49,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 666 ug/plate
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-359,1989
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in microorganisms
: Bacteria - Escherichia coli
: 10 mg/L
(Research
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
44,305,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 50 umol/L
REFERENCE :
BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France)
V.531966- Volume(issue)/page/year: 67,245,1980
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 50 umol/L
REFERENCE :
BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France)
V.531966- Volume(issue)/page/year: 67,245,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000
Stuttgart
1, Fed. Rep. Ger.) V.11953- Volume(issue)/page/year: 42,333,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000
Stuttgart
1, Fed. Rep. Ger.) V.11953- Volume(issue)/page/year: 42,333,1981
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 20 mg/L
REFERENCE :
CEDEDE Clinical and Experimental Dermatology. (Blackwell Scientific Pub.
Ltd., POB 88, Oxford, UK) V.11976- Volume(issue)/page/year:
5,147,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
(Research
Triangle Park, NC 27709) No.206NTP-TR-359,1989
Volume(issue)/page/year:
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 33300 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-359,1989
(Research
*** REVIEWS ***
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,101,1980
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,101,1980
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
1(1),93,1971
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis; S
cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: Aspergillus-forward mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-human lymphocytes;
In
vitro SCE-human
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-359,1989
(Research
NTP 8th Annual Report on Carcinogens, 1998: Known to be human carcinogen
METHOXYSALICYLALDEHYDE (5-)
RTECS NUMBER
: BZ2800000
CHEMICAL NAME
: m-Anisaldehyde, 6-hydroxyCAS REGISTRY NUMBER
: 672-13-9
BEILSTEIN REFERENCE NO. : 1100532
REFERENCE
: 4-08-00-01759 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C8-H8-O3
MOLECULAR WEIGHT
: 152.16
WISWESSER LINE NOTATION : VHR BQ EO1
SYNONYMS/TRADE NAMES :
* Benzaldehyde, 2-hydroxy-5-methoxy* 2-Hydroxy-5-methoxybenzaldehyde
* 5-Methoxysalicylaldehyde
* Salicylaldehyde, 5-methoxy*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 6,228,1954
METHYL ACETATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
AI9100000
Acetic acid, methyl ester
79-20-9
199907
52
C3-H6-O2
74.09
1VO1
COMPOUND DESCRIPTOR
: Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetate de methyle
* Devoton
* Ethyl ester of monoacetic acid
* Methylacetaat
* Methylacetat
* Methyl acetate
* Methyle (acetate de)
* Methylester kiseliny octove
* Methyl ethanoate
* Metile (acetato di)
* Octan metylu
* Tereton
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,353,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,353,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Human
15000 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
(Berlin, Ger.)
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa
Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927Volume(issue)/page/year: 18,45,1943
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 34 gm/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LCLo - Lowest published lethal concentration
Inhalation
Mammal - cat
67 gm/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3705 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
41,31,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraduodenal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,859,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 214 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(8),107,1968
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 28 gm/m3/40M/4W-I
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572401
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 33800 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
149,339,1985
*** REVIEWS ***
ACGIH TLV-STEL 757 mg/m3 (250 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 606 mg/m3 (200 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
TLV/BEI,1997
Volume(issue)/page/year:
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
21,28,1960
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (610 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,153,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (610 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 200 ppm (610 mg/m3), JAN1999
OEL-BELGIUM:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993
OEL-DENMARK: TWA 150 ppm (455 mg/m3), JAN1999
OEL-FINLAND:TWA 200 ppm (610 mg/m3);STEL 250 ppm (765 mg/m3) JAN 1993
OEL-JAPAN: OEL 200 ppm (610 mg/m3), JAN1999
OEL-GERMANY:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-HUNGARY:TWA 200 mg/m3;STEL 500 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 100 mg/m3, MAC(STEL) 750 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-SWEDEN: TWA 150 ppm (450 mg/m3), STEL 300 ppm (900 mg/m3), JAN1999
OEL-THE PHILIPPINES:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (610 mg/m3);STEL 400 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (610 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (610 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ACETATE-air:10H TWA 200 ppm;STEL 250 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46410
No. of Facilities: 1604 (estimated)
No. of Industries: 26
No. of Occupations: 22
No. of Employees: 5611 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46410
No. of Facilities: 387 (estimated)
No. of Industries: 15
No. of Occupations: 31
No. of Employees: 20455 (estimated)
No. of Female Employees: 6018 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Methyl acetate, 1458
METHYL ACETOACETATE
RTECS NUMBER
: AK5775000
CHEMICAL NAME
: Acetoacetic acid, methyl ester
CAS REGISTRY NUMBER
: 105-45-3
LAST UPDATED
: 199701
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C5-H8-O3
MOLECULAR WEIGHT
: 116.13
WISWESSER LINE NOTATION : 1V1VO1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetoacetic methyl ester
* Butanoic acid, 3-oxo-, methyl ester
* Methylacetoacetate
* Methyl acetylacetate
* Methyl acetylacetonate
* Methylester kyseliny acetoctove
* Methyl 3-oxobutanoate
* Methyl 3-oxobutyrate
* 3-Oxobutanoic acid methyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,815,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration into the eye
: Rodent - rabbit
DOSE/DURATION
: 2 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3228 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84355
No. of Facilities: 23 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 270 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84355
No. of Facilities: 30 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 1872 (estimated)
No. of Female Employees: 336 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL ACRYLATE
RTECS NUMBER
: AT2800000
CHEMICAL NAME
: Acrylic acid, methyl ester
CAS REGISTRY NUMBER
: 96-33-3
BEILSTEIN REFERENCE NO. : 0605396
REFERENCE
: 4-02-00-01457 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 62
MOLECULAR FORMULA
: C4-H6-O2
MOLECULAR WEIGHT
: 86.10
WISWESSER LINE NOTATION : 1U1VO1
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acrylate de methyle
* Acrylsaeuremethylester
* Curithane 103
* Methoxycarbonylethylene
* Methylacrylaat
* Methyl-acrylat
* Methyl acrylate
* Methylester kyseliny akrylove
* Methyl propenate
* Methyl propenoate
* Methyl-2-propenoate
* Metilacrilato
* 2-Propenoic acid, methyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 578 ppm/49H (Intermittent)
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,317,1949
TYPE OF TEST
: Immersion
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100%/1M
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,317,1949
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rabbit
100 mg
Severe
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,368,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 75 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - other changes
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,75,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 277 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 36,58,1975
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1350 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,811,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 36,58,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 827 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
11,125,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 23(9),55,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 254 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 51,526,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,317,1949
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2522 ppm/1H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,317,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1243 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 109 gm/kg/2Y-C
TOXIC EFFECTS :
Behavioral - fluid intake
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
6,29,1964
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ug/m3/24H/14W-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in spleen
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(10),3,1967
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
(V/O
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 71 mg/m3/3H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(1),34,1980
(V/O
** MUTATION DATA **
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 37500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,189,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 22 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),4,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 22 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),4,1986
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 14 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,49,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 189 ppm
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(102),77,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Cytogenetic analysis
: Rodent - hamster Lung
: 6500 ug/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research.
St., New York, NY 10013) No. 11197127,95,1981
(Plenum Pub. Corp., 233 Spring
Volume(issue)/page/year:
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 7 mg/m3 (2 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,99,1986
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,99,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,141,1975
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 10 ppm (35 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,154,1971
OSHA PEL (Gen Indu):8H TWA 10 ppm (35 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 10 ppm (35 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 10 ppm (35 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 10 ppm (35 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (35 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 5 ppm (18 mg/m3), JAN1999
OEL-BELGIUM:TWA 10 ppm (35 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 10 ppm (35 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 10 ppm (35 mg/m3);STEL 20 ppm (70 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 5 ppm (18 mg/m3) JAN 1993
OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (35 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (35 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 20 mg/m3, MAC(STEL) 70 mg/m3, JAN1999
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWEDEN:TWA 10 ppm (35 mg/m3);STEL 15 ppm (50 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (18 mg/m3);STEL 10 ppm;Skin JAN 1993
OEL-TURKEY:TWA 10 ppm (35 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (35 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ACRYLATE-air:10H TWA 10 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46450
No. of Facilities: 931 (estimated)
No. of Industries: 22
No. of Occupations: 14
No. of Employees: 11809 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46450
No. of Facilities: 129 (estimated)
No. of Industries: 6
No. of Occupations: 16
No. of Employees: 9762 (estimated)
No. of Female Employees: 3877 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Methyl acrylate, 1459
METHYL ANTHRANILATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: CB3325000
: Anthranilic acid, methyl ester
: 134-20-3
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
0606965
4-14-00-01008 (Beilstein Handbook Reference)
199710
11
C8-H9-N-O2
151.18
ZR BVO1
Mutagen
Reproductive Effector
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* o-Aminobenzoic acid methyl ester
* 2-Aminobenzoic acid methyl ester
* Benzoic acid, 2-amino-, methyl ester
* o-Carbomethoxyaniline
* 2-Carbomethoxyaniline
* 2-(Methoxycarbonyl)aniline
* Methyl o-aminobenzoate
* Methyl 2-aminobenzoate
* Methyl anthranilate
* Methylester kyseliny anthranilove
* Neroli oil, artifical
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,935,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2910 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
3900 mg/kg
Behavioral - somnolence (general depressed activity)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,935,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2780 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
34800 mg/kg
male 8 day(s) pre-mating
female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland)
V.12-17, 1965-67. For publisher information, see PHMGBN.
Volume(issue)/page/year: 15,7,1966
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 23 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical
Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54
Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.2434,267,1985
1975- Volume(issue)/page/year:
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1207
No. of Facilities: 174 (estimated)
No. of Industries: 3
No. of Occupations: 17
No. of Employees: 2956 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1207
No. of Facilities: 7048 (estimated)
No. of Industries: 66
No. of Occupations: 71
No. of Employees: 104513 (estimated)
No. of Female Employees: 49243 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL ASPARTIC ACID (N,D-)
RTECS NUMBER
: CI9457000
CHEMICAL NAME
: D-Aspartic acid, N-methylCAS REGISTRY NUMBER
: 6384-92-5
BEILSTEIN REFERENCE NO. : 1724431
REFERENCE
: 3-04-00-01522 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C5-H9-N-O4
MOLECULAR WEIGHT
: 147.15
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* N-Methyl-D-aspartate
* N-Methyl-D-aspartic acid
* NMDA
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
137 mg/kg
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 269,573,1994
METHYL BLUE
RTECS NUMBER
CHEMICAL NAME
V.1-
1909/10-
: DB5044700
: Benzenesulfonic acid,
((4-(bis(4-((sulfophenyl)amino)phenyl)methylene)-2,5cyclohexadien- 1-ylidene)amino)-, disodium salt
CAS REGISTRY NUMBER
: 28983-56-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C37-H27-N3-O9-S3.2Na
MOLECULAR WEIGHT
: 799.83
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Acid Blue 93
* Acid Leather Blue HER
* Brilliant Lake Blue G
* C.I. 42780
* C.I. Acid Blue 93, disodium salt
* Cotton Blue
* Helvetia Blue
* Helvetia Blue I
* Helvetia Blue Pure I
* Ink Blue
* Ink Blue BA
* Ink Blue BJTBN 80
* Ink Blue BJTBNA 80
* Ink Blue BJTN
* Ink Blue G
* Ink Blue M
* Ink Blue N
* Ink Blue Special
* Ink Blue WGS
* Ink Blue WRS
* Methyl Blue
* Methyl Blue (biological stain)
* Modr Kysela 93
* Orient Soluble Blue OBB
* Pure Soluble Blue I
* Silk Blue H
* Sky Blue G
* Solar Soluble Blue BN
* Soluble Blue
* Soluble Blue 8B
* Special Soluble Blue HT
* Water Blue B
* Water Blue IN
* Water Blue I Old Type 1240A
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1455
No. of Facilities: 176 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 505 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1455
No. of Facilities: 89 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 961 (estimated)
No. of Female Employees: 630 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL BROMOACETATE
RTECS NUMBER
: AF6300000
CHEMICAL NAME
: Acetic acid, bromo-, methyl ester
CAS REGISTRY NUMBER
: 96-32-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C3-H5-Br-O2
MOLECULAR WEIGHT
: 152.99
WISWESSER LINE NOTATION : E1VO1
SYNONYMS/TRADE NAMES :
* Bromoacetic acid methyl ester
* Methyl alpha-bromoacetate
* Methylester kyseliny bromoctove
* Methyl monobromoacetate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 6,138,1954
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7133
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1822 (estimated)
No. of Female Employees: 272 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL BROMOCROTONATE (4-)
RTECS NUMBER
: GQ3120000
CHEMICAL NAME
: Crotonic acid, 4-bromo-, methyl ester
CAS REGISTRY NUMBER
: 1117-71-1
BEILSTEIN REFERENCE NO. : 1745755
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C5-H7-Br-O2
MOLECULAR WEIGHT
: 179.03
WISWESSER LINE NOTATION : E2U1VO1
SYNONYMS/TRADE NAMES :
* 2-Butenoic acid, 4-bromo-, methyl ester
* Methyl 4-bromo-2-butenoate
* Methyl bromocrotonate
* Methyl gamma-bromocrotonate
* Methyl 4-bromocrotonate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00811
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL BROMOPROPIONATE (3-)
RTECS NUMBER
: UA2451790
CHEMICAL NAME
: Propanoic acid, 3-bromo-, methyl ester
CAS REGISTRY NUMBER
: 3395-91-3
LAST UPDATED
: 199710
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C4-H7-Br-O2
MOLECULAR WEIGHT
: 167.02
SYNONYMS/TRADE NAMES :
* 3-Bromopropanoic acid methyl ester
* Methyl 3-bromopropanoate
* Methyl beta-bromopropionate
* Propionic acid, 3-bromo-, methyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Vascular - regional or general arteriolar or venous dilation
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570991
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL CELLULOSE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
:
:
:
:
FJ5959000
Cellulose, methyl ether (1/2%)
9004-67-5
199710
DATA ITEMS CITED
: 6
SYNONYMS/TRADE NAMES :
* Adulsin
* Bagolax
* Bufapto methalose
* Bulkaloid
* Celacol M
* Celacol M20
* Celacol M450
* Celacol MM
* Celacol MM 10P
* Celacol M 20P
* Cellapret
* Cellogran
* Cellothyl
* Cellulose methyl
* Cellulose methylate
* Cellumeth
* Cethylose
* Cethytin
* Culminal K 42
* Edisol M
* Hydrolose
* Mapolose M25
* Mapolose 60SH50
* MCO 8000
* MC 4000 cP
* MC 20000S
* Mellose
* Methocel 10
* Methocel 15
* Methocel 181
* Methocel 400
* Methocel 4000
* Methocel A
* Methocel CHG
* Methocel 400CPS
* Methocel 4000CPS
* Methocel MC
* Methocel MC 25
* Methocel MC4000
* Methocel MC 8000
* Methocel SM 100
* Methulose
* Methylcellulose
* Methylcellulose (1/2%)
* Methyl cellulose-A
* Methyl cellulose ether
* Metolose MC 8000
* Metolose 60SH
* Metolose 60SH400
* Metolose SM 15
* Metolose SM 100
* Metolose SM 4000
* MMTs-BTR
* MTs
* Napolone
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Nicel
Rhomellose
Syncelose
Tylose 444
Tylose A4S
Tylose MF
Tylose MH20
Tylose MH50
Tylose MH300
Tylose MH1000
Tylose MH2000
Tylose MH4000
Tylose MH300P
Tylose SAP
Tylose SL
Tylose SL 100
Tylose SL 400
Tylose SL 600
Tylose TWA
USP methylcellulose
Viscol
Viscontran L52
Viscosol
Walsroder MC 20000S
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 275 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD628-313
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,685,1956
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80304
No.
No.
No.
No.
of
of
of
of
Facilities: 3984 (estimated)
Industries: 62
Occupations: 63
Employees: 53298 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X8583
No. of Facilities: 5594 (estimated)
No. of Industries: 62
No. of Occupations: 80
No. of Employees: 108851 (estimated)
No. of Female Employees: 40524 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL CHLOROFORMATE
RTECS NUMBER
: FG3675000
CHEMICAL NAME
: Carbonochloridic acid, methyl ester
CAS REGISTRY NUMBER
: 79-22-1
BEILSTEIN REFERENCE NO. : 0605437
REFERENCE
: 4-03-00-00023 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 19
MOLECULAR FORMULA
: C2-H3-Cl-O2
MOLECULAR WEIGHT
: 94.50
WISWESSER LINE NOTATION : GVO1
COMPOUND DESCRIPTOR
: Human
SYNONYMS/TRADE NAMES :
* Chlorameisensaeure methylester
* Chlorocarbonate de methyle
* Chlorocarbonic acid methyl ester
* Chloroformiate de methyle
* Chloroformic acid methyl ester
* Formic acid, chloro-, methyl ester
* MCF
* Methoxycarbonyl chloride
* Methylchloorformiaat
* Methyl chlorocarbonate
* Methylester kyseliny chlormravenci
* Methylester kyseliny chloruhlicite
* Metilcloroformiato
* RCRA waste number U156
* TL 438
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 5 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
(V/O
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 88 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,417,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 185 mg/m3/2H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle weakness
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1500 mg/m3/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 7120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,417,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 34360 ug/m3/6H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570775
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 720 ug/m3/17W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 640 ug/m3/17W-I
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(5),97,1977
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4785
No. of Facilities: 257 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 3949 (estimated)
No. of Female Employees: 408 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
(V/O
(V/O
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL DIHYDROXYPHENYLALANINE (3:3,4-)
RTECS NUMBER
: AY5940000
CHEMICAL NAME
: Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, DLCAS REGISTRY NUMBER
: 555-29-3
LAST UPDATED
: 199403
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C10-H13-N-O4
MOLECULAR WEIGHT
: 211.24
WISWESSER LINE NOTATION : QVXZ1&1R CQ DQ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 3-Hydroxy-alpha-methyl-DL-tyrosine
* Metholes
* (+-)-alpha-Methyldopa
* DL-Methyldopa
* DL-alpha-Methyl DOPA
* racemic alpha-Methyldopa
* (RS)-alpha-Methyldopa
* Mulfasin
* DL-Tyrosine, 3-hydroxy-alpha-methyl*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-348,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-348,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-348,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1317 mg/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 23,1318,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-348,1989
METHYL DIPHENYL PHOSPHINE OXIDE
RTECS NUMBER
: SZ0199480
CHEMICAL NAME
: Phosphine oxide, diphenylmethylCAS REGISTRY NUMBER
: 2129-89-7
BEILSTEIN REFERENCE NO. : 0957291
REFERENCE
: 2-16-00-00378 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C13-H13-O-P
MOLECULAR WEIGHT
: 216.23
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Diphenylmethylphosphine oxide
* Methyldiphenylphosphine oxide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical
Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11967- Volume(issue)/page/year: 24(4),22,1990
METHYL DIPYRIDYL PROPANONE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
OTHER CAS REGISTRY NOS. :
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
(2,1,2,3,1-)
UC3050000
1-Propanone, 2-methyl-1,2-di-3-pyridyl54-36-4
37245-80-0
199504
13
C14-H14-N2-O
226.30
T6NJ CX1&1&V- CT6NJ
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1,2-Di-3-pyridyl-2-methyl-1-propanone
* Mepyrapone
* Methapyrapone
* Methopirapone
* Methopyrapone
* Methopyrinine
* Methopyrone
* 2-Methyl-1,2-bis(3-pyridyl)-1-propane
* 2-Methyl-1,2-di-3-pyridinyl-1-propanone
* Metopiron
* Metopirone
* Metopyrone
* Metyrapon
* Metyrapone
* 1-Propanone, 1,2-di-3-pyridyl-2-methyl* 1-Propanone, 2-methyl-1,2-di-3-pyridinyl* SU-4885
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 521 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,827,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 146,395,1964
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 531 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Cesko-Slovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1-42, 1952-93. For
publisher information, see CSLFEK Volume(issue)/page/year: 26,140,1977
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 270 mg/kg
SEX/DURATION
: female 19-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - respiratory system
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
PEREBL Pediatric Research.
Baltimore, MD 21202) V.1TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
(Williams & Wilkins Co., 428 E. Preston St.,
1967- Volume(issue)/page/year: 20,672,1986
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
2160 mg/kg
female 8-19 day(s) after conception
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.11932- Volume(issue)/page/year:
39,184,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2600 mg/kg
SEX/DURATION
: male 13 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.11945- Volume(issue)/page/year: 89,240,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE
: 800 mg/kg
SEX/DURATION
: male 40 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1,
Poland) V.11953- Volume(issue)/page/year: 27,277,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Mammal - dog
DOSE
: 18 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 17,937,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 300 mg/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
1963-
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Reproductive - Paternal Effects - other effects on male
REFERENCE :
ENDKAC Endokrinologie. (Leipzig, Ger. Dem. Rep.) V.1-80, 1928-82. For
publisher information, see EXCEDS. Volume(issue)/page/year: 72,291,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - gerbil
DOSE
: 100 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.11932- Volume(issue)/page/year:
35,521,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 600 mg/kg
SEX/DURATION
: male 6 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.11945- Volume(issue)/page/year: 89,240,1974
** MUTATION DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
TEST SYSTEM
:
DOSE/DURATION
:
REFERENCE :
FOBGA8 Folia Biologica
Poland) V.11953-
Mutation test systems - not otherwise specified
Intraperitoneal
Mammal - dog
800 mg/kg/40D (Continuous)
(Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1,
Volume(issue)/page/year: 27,277,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5298
No. of Facilities: 34 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1271 (estimated)
No. of Female Employees: 660 (estimated)
METHYL ETHYL KETONE PEROXIDE
RTECS NUMBER
: EL9450000
CHEMICAL NAME
: 2-Butanone, peroxide
CAS REGISTRY NUMBER
: 1338-23-4
LAST UPDATED
: 199907
DATA ITEMS CITED
: 30
MOLECULAR FORMULA
: C8-H16-O4
MOLECULAR WEIGHT
: 176.24
WISWESSER LINE NOTATION : 1V2OO2V1
COMPOUND DESCRIPTOR
: Tumorigen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Butanox LPT
* Butanox M 50
* Butanox M 105
* Chaloxyd MEKP-HA 1
* Chaloxyd MEKP-LA 1
* Esperfoam FR
* Ethyl methyl ketone peroxide
* FR 222
* HI-Point 90
* HI-Point 180
* HI-Point PD-1
* Kayamek A
* Kayamek M
* Ketonox
* Lucidol DDM 9
* Lucidol Delta X
* Lupersol DDA 30
* Lupersol DDM
* Lupersol Delta X
* Lupersol DNF
* Lupersol DSW
* MEK peroxide
* MEKPO
* Mepox
* Methyl ethyl ketone hydroperoxide
* Methyl ethyl ketone peroxide
* Methylethylketonhydroperoxide
* NCI-C55447
* Permek G
* Permek N
* Quickset Extra
* Quickset super
* RCRA waste number U160
* Sprayset MEKP
* Superox 46-710
* Thermacure
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration onto the skin
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3 mg
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 480 mg/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
REFERENCE :
NCPBBY National Clearinghouse for Poison Control Centers, Bulletin.
(U.S.
Department of Health, Education, and Welfare, Washington, DC)
Volume(issue)/page/year: Jan/Feb,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 484 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - rat
65 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
165,201,1957
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 170 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2033 mg/kg/7W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 273 mg/kg/7W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,205,1958
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 282 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67.
Discontinued. Volume(issue)/page/year: 3,193,1963
*** REVIEWS ***
ACGIH TLV-CL 1.5 mg/m3 (0.2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-BELGIUM:STEL 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-DENMARK: TWA 1 mg/m3, JAN1999
OEL-FINLAND:STEL 0.2 ppm (1.5 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-SWEDEN:STEL 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.2 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ETHYL KETONE PEROXIDE-air:CL 0.2 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80105
No. of Facilities: 2226 (estimated)
No. of Industries: 29
No. of Occupations: 31
No. of Employees: 20053 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80105
No. of Facilities: 1879 (estimated)
No. of Industries: 23
No. of Occupations: 31
No. of Employees: 25827 (estimated)
No. of Female Employees: 6514 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Methyl ethyl ketone peroxide, 3508
NTP Toxicity studies, RPT# TOX-18, May 1999
METHYL EUGENOL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
CY2450000
Benzene, 4-allyl-1,2-dimethoxy93-15-2
1910871
4-06-00-06337 (Beilstein Handbook Reference)
199907
17
C11-H14-O2
178.25
1U2R CO1 DO1
Agricultural Chemical
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1-Allyl-3,4-dimethoxybenzene
* 4-Allyl-1,2-dimethoxybenzene
* 4-Allylveratrole
* 1,2-Dimethoxy-4-allylbenzene
* 1-(3,4-Dimethoxyphenyl)-2-propene
* ENT 21040
* 1,3,4-Eugenol methyl ether
* Eugenyl methyl ether
* Methyl eugenol
* Veratrole methyl ether
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,857,1975
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 810 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,857,1975
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >4800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
31,421,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 540 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - somnolence (general depressed activity)
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.41898- Volume(issue)/page/year: 199,226,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 112 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - somnolence (general depressed activity)
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 199,226,1972
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2025 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
31,421,1975
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4200 mg/kg/6W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.11968- Volume(issue)/page/year: 14,367,1976
** MUTATION DATA **
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1360 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,427,1989
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
28,537,1990
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523)
Volume(issue)/page/year:
34,337,1996
V.20-
1982-
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1613,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 04500
No. of Facilities: 41 (estimated)
No. of Industries: 2
No. of Occupations: 21
No. of Employees: 2840 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 04500
No. of Facilities: 1074 (estimated)
No. of Industries: 5
No. of Occupations: 10
No. of Employees: 12682 (estimated)
No. of Female Employees: 9413 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; selected, May 1999
NTP Carcinogenesis studies; test completed (post peer review), May 1999
METHYL FORMATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
LQ8925000
Formic acid, methyl ester
107-31-3
199907
29
C2-H4-O2
60.06
VHO1
Agricultural Chemical
*
*
*
*
*
*
*
*
*
Formiate de methyle
Methylester kyseliny mravenci
Methyle (formiate de)
Methyl formate
Methylformiaat
Methylformiat
Methyl methanoate
Metil (formiato di)
Mravencan methylnaty
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1622 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
41,31,1972
*** REVIEWS ***
ACGIH TLV-STEL 368 mg/m3 (150 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 246 mg/m3 (100 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
20,517,1959
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 100 ppm (250 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,165,1971
OSHA PEL (Gen Indu):8H TWA 100 ppm (250 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 100 ppm (250 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 100 ppm (250 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 100 ppm (250 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 100 ppm (250 mg/m3);STEL 150 ppm (375 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 100 ppm (250 mg/m3), JAN1999
OEL-AUSTRIA:TWA 100 ppm (250 mg/m3) JAN 1993
OEL-BELGIUM:TWA 100 ppm (246 mg/m3);STEL 150 ppm (369 mg/m3) JAN 1993
OEL-DENMARK: TWA 100 ppm (250 mg/m3), JAN1999
OEL-FINLAND:TWA 100 ppm (250 mg/m3);STEL 150 ppm (375 mg/m3) JAN 1993
OEL-GERMANY:TWA 100 ppm (250 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (250 mg/m3);STEL 200 ppm JAN 1993
OEL-THE PHILIPPINES:TWA 100 ppm (250 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 100 ppm (250 mg/m3);STEL 200 ppm (500 mg/m3) JAN 1993
OEL-SWEDEN: TWA 100 ppm (250 mg/m3), STEL 150 ppm (350 mg/m3), JAN1999
OEL-TURKEY:TWA 100 ppm (250 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (250 mg/m3);STEL 150 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL FORMATE-air:10H TWA 100 ppm;STEL 150 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 33850
No. of Facilities: 80 (estimated)
No. of Industries: 6
No. of Occupations: 22
No. of Employees: 7738 (estimated)
No. of Female Employees: 1402 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL HYDROXYBENZOATE (4-)
RTECS NUMBER
: DH2450000
CHEMICAL NAME
: Benzoic acid, p-hydroxy-, methyl ester
CAS REGISTRY NUMBER
: 99-76-3
BEILSTEIN REFERENCE NO. : 0509801
REFERENCE
: 4-10-00-00360 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: C8-H8-O3
MOLECULAR WEIGHT
: 152.16
WISWESSER LINE NOTATION : QR DVO1
COMPOUND DESCRIPTOR
: Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Abiol
* Aseptoform
* p-Hydroxybenzoic acid methyl ester
* Maseptol
* Metaben
* Methylben
* Methyl chemosept
* Methyl ester of p-hydroxybenzoic acid
* Methylester kyseliny p-hydroxybenzoove
* Methyl p-hydroxybenzoate
* Methyl p-oxybenzoate
* Methylparaben
* Methyl parahydroxybenzoate
* Methyl parasept
* Metoxyde
*
*
*
*
*
*
*
*
*
*
Moldex
Nipagin
Nipagin M
p-Oxybenzoesauremethylester
Paridol
Preserval M
Septos
Solbrol
Solbrol M
Tegosept M
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 4(2),185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,260,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 960 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,260,1956
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 128,135,1960
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 125 mg/L/27H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,277,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 500 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(96),55,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 4,575,1954
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80461
No. of Facilities: 4469 (estimated)
No. of Industries: 33
No. of Occupations: 50
No. of Employees: 57029 (estimated)
NOES - National Occupational
NOES Hazard Code - 80461
No. of Facilities: 15369
No. of Industries: 94
No. of Occupations: 117
No. of Employees: 590361
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
398916 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL IMIDAZOLINE (2:2-)
RTECS NUMBER
: NI4804995
CHEMICAL NAME
: 1H-Imidazole, 4,5-dihydro-2-methylCAS REGISTRY NUMBER
: 534-26-9
BEILSTEIN REFERENCE NO. : 0104225
REFERENCE
: 5-23-03-00385 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C4-H8-N2
MOLECULAR WEIGHT
: 84.14
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 4,5-Dihydro-2-methyl-1H-imidazole
* 2-Imidazoline, 2-methyl* Lysidine
* Methylglyoxalidine
* 2-Methylimidazoline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11879- Volume(issue)/page/year: 57,2424,1935
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11879- Volume(issue)/page/year: 57,2424,1935
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL INDOLE (5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 5-Nitroindole
* 5-Nitro-1H-indole
:
:
:
:
:
:
:
:
:
NM1168200
Indole, 5-nitro6146-52-7
199410
2
C8-H6-N2-O2
162.16
T56 BMJ INW
Mutagen
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
173,169,1986
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
METHYL ISOTHIOCYANATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
PA9625000
Methane, isothiocyanato556-61-6
199710
27
C2-H3-N-S
73.12
SCN1
Agricultural Chemical
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Isothiocyanate de methyle
* Isothiocyanatomethane
* Isothiocyanic acid, methyl ester
* Isotiocianato di metile
* MeNCS
* Methylisothiocyanaat
* Methyl-isothiocyanat
* Methylisothiokyanat
* Methyl mustard oil
* Methylsenfoel
* MIT
* Morton EP-161E
* Trapex
* Trapex-40
* Trapexide
* WN 12
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
ROUTE OF EXPOSURE
: Standard Draize test
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - coma
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
283,18,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1900 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und
Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 54 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 34(5),33,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - mouse
1820 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und
Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 82 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 5,505,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,417,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: 136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
9,581,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3640 mg/kg/13W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Related to Chronic Data - changes in ovarian weight
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45 ppm/4H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14400 mg/kg/30D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1820 mg/kg/13W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Related to Chronic Data - changes in ovarian weight
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7123 mg/kg/2Y-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 225 mg/kg/5D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - other changes
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 47,479,1996
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society
of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.11976- Volume(issue)/page/year: 15,297,1990
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1140
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1683 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL ISOVALERATE
RTECS NUMBER
: NY1510000
CHEMICAL NAME
: Isovaleric acid, methyl ester
CAS REGISTRY NUMBER
: 556-24-1
BEILSTEIN REFERENCE NO. : 1699922
REFERENCE
: 4-02-00-00897 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C6-H12-O2
MOLECULAR WEIGHT
: 116.18
WISWESSER LINE NOTATION : 1Y1&1VO1
SYNONYMS/TRADE NAMES :
* Butanoic acid, 3-methyl-, methyl ester
* Methyl isopentanoate
* Methyl 3-methylbutanoate
* Methyl 3-methylbutyrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20250 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,84,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5693 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5.
41,31,1972
Volume(issue)/page/year:
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 18800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0373
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 427 (estimated)
No. of Female Employees: 176 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL MERCURY CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Caspan
* Chloromethylmercury
:
:
:
:
:
:
:
:
:
:
:
OW1225000
Mercury, chloromethyl115-09-3
3600218
4-04-00-04436 (Beilstein Handbook Reference)
199907
162
C-H3-Cl-Hg
251.08
G-HG-1
Tumorigen
Drug
Organometallic
Mutagen
Reproductive Effector
*
*
*
*
*
*
Mercurymethylchloride
Methylmercuric chloride
Methylmercury chloride
Methylmercury monochloride
Methylmerkurichlorid
Monomethyl mercury chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 29915 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 14,140,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11 mg/kg
TOXIC EFFECTS :
Blood - hemorrhage
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,313,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23 mg/kg
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Blood - hemorrhage
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 57600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACATA5 Acta Anatomica.
(S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003)
V.1-
1945-
Volume(issue)/page/year: 104,356,1979
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1198,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,445,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 5600 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 15,5,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 35,343,1929
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
V.1-
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
21 mg/kg
1909/10-
Behavioral - tremor
Gastrointestinal - changes in structure or function of salivary glands
Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,545,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 7 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - changes in structure or function of salivary glands
Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,545,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - coma
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 15,5,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 26 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,105,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,105,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg/10D-I
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 42,193,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 mg/kg/2D-I
TOXIC EFFECTS :
Brain and Coverings - changes in surface EEG
Behavioral - altered sleep time (including change in righting reflex)
Biochemical - Neurotransmitters or modulators (putative) - catecholamine
levels in CNS
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
23,245,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 105 mg/kg/12W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 6,85,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91 mg/kg/2Y-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in other cell count (unspecified)
Related to Chronic Data - death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 6,107,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
50 mg/kg/13D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - amino acids (including renal
excretion)
Biochemical - Neurotransmitters or modulators (putative) - dopamine at
other
sites
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
13,195,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg/50D-I
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic
Vascular - regional or general arteriolar constriction
Biochemical - Neurotransmitters or modulators (putative) - dopamine at
other
sites
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
13,159,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg/6D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,122,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 mg/kg/28D-I
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
89,144,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
116 mg/kg/6W-I
TOXIC EFFECTS :
Endocrine - adrenal cortex hyperplasia
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 6,597,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 55 mg/kg/13D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
89,144,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg/7D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 61,37,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 116 mg/kg/6W-I
TOXIC EFFECTS :
Endocrine - adrenal cortex hyperplasia
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 6,597,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/kg/15D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)1984Volume(issue)/page/year: 9,201,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg/60D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 32,543,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 662 mg/kg/10W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 4(5-6),47,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17 mg/kg/5D-I
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 15,175,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg/10D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
6,319,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 30 mg/kg/96D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - muscle weakness
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
27,569,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 47046 ug/kg/57W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 5,337,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 115 mg/kg/14W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - decrease in humoral immune response
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 2,1115,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 18 mg/kg/5D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,105,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - ataxia
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Mammal - species unspecified
31 mg/kg/93D-C
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
CJCMAV Canadian Journal of Comparative Medicine. (Ottawa, ON, Canada)
V.1-3, 1937-39; V.32-49, 1968-85. For publisher information, see CJVRE9.
Volume(issue)/page/year: 40,34,1976
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 402 mg/kg/58W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 8,329,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 731 mg/kg/58W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year: 18(Suppl
1),114,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5359 mg/kg/58W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year: 18(Suppl
1),114,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 668 mg/kg/53W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
12,305,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 660 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NJUZA9 Japanese Journal of Veterinary Science. (Nippon Jui Gakkai,
1-37-20
Yoyogi, Shibuya-ku, Tokyo 151, Japan) V.11939Volume(issue)/page/year: 48,127,1986
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 876 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Brain and Coverings - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 14,179,1990
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 225 ug/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,222,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 25 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
BIPCBF Biological Psychiatry. (Plenum Pub. Corp., 233 Spring St., New
York,
NY 10013) V.11969- Volume(issue)/page/year: 8,307,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 15,1,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 ug/kg
SEX/DURATION
: female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,103,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6 mg/kg
SEX/DURATION
: female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
PARWAC Polskie Archiwum Weterynaryjne. Polish Archives of Veterinary
Medicine. (Panstwowe Wydawnictwo Naukowe, POB 391, 00251 Warsaw, Poland)
V.11951- Volume(issue)/page/year: 22,263,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1572 ug/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
22,287,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 mg/kg
SEX/DURATION
: female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
7,775,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 14 mg/kg
SEX/DURATION
: female 8-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of
Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan)
V.11949/50- Volume(issue)/page/year: 37,313,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
7700 ug/kg
male 8 week(s) pre-mating
female 8 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 74,34,1997
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
5 mg/kg
female 1 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
9,189,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 2 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
9,189,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
9,189,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
9,189,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
4 mg/kg
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 8,277,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 251,236,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 mg/kg
SEX/DURATION
: female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third
Ave., New York, NY 10158) V.11968- Volume(issue)/page/year:
14,213,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8 mg/kg
SEX/DURATION
: female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(3),18A,1984
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
TDLo - Lowest published toxic dose
Unreported
Rodent - rat
16 mg/kg
female 1-8 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
REFERENCE :
KUIZAR Kumamoto Igakkai Zasshi. Journal of the Kumamoto Medical Society.
(Kumamoto Igakkai, c/o Kumamoto Daigaku Igakubu, 2-1, 2-chome
Honjo-machi,
Kumamoto, Japan) V.11925- Volume(issue)/page/year: 41,506,1967
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Unreported
Rodent - rat
32 mg/kg
female 6-9 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 27,67A,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 27,36A,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 24 mg/kg
SEX/DURATION
: female 8-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,16A,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
6,379,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.11945- Volume(issue)/page/year: 104,356,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 15 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.11945- Volume(issue)/page/year: 104,356,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
OEKSDJ Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Shokuhin Eisei
Hen. Research Reports of the Osaka Prefectural Institute of Public
Health,
Food Sanitation Section. (Osaka-furitsu Koshu Eisei Kenkyusho, 1-3-69
Nakamichi, Higashinari-ku, Osaka 537, Japan) No.11970-
Volume(issue)/page/year: 8,7,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12 mg/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,245,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,
Jena DDR-6900, Ger. Dem. Rep.) V.11886- Volume(issue)/page/year:
153,69,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 17500 ug/kg
SEX/DURATION
: female 11-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 24,259,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7500 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
25,199,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 8 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
DENED7 Developmental Neuroscience (Basel). (S. Karger Pub., Inc., 79
Fifth
Ave., New York, NY 10003) V.11978- Volume(issue)/page/year:
5,216,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 20 mg/kg
SEX/DURATION
: female 10-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,437,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6260 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 16,187,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 34932 ug/kg
SEX/DURATION
: female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 19,39,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 750 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 23,397,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6259 ug/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 33,231,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 27 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,27B,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 25 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 34,471,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12517 ug/kg
SEX/DURATION
: female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 49,541,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12517 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 49,541,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 18,145,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 8 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 31,45A,1985
V.1-
1968-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE
: 6300 ug/kg
SEX/DURATION
: female 1-63 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected
Papers Presented and Papers Reviewed at the 8th Inter-American Conference
on
Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B.,
ed., New York, Stratton Intercontinental Medical Book Corp., 1973
Volume(issue)/page/year: -,253,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 3040 ug/kg
SEX/DURATION
: female 20-38 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
29,138,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Primate - monkey
DOSE
: 10800 ug/kg
SEX/DURATION
: female 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25(2),45A,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE
: 12250 ug/kg
SEX/DURATION
: female 10-58 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 8,293,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 6 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
PARWAC Polskie Archiwum Weterynaryjne. Polish Archives of Veterinary
Medicine. (Panstwowe Wydawnictwo Naukowe, POB 391, 00251 Warsaw, Poland)
V.11951- Volume(issue)/page/year: 22,263,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - pig
DOSE
: 5700 ug/kg
SEX/DURATION
: female 1-16 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected
Papers Presented and Papers Reviewed at the 8th Inter-American Conference
on
Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B.,
ed., New York, Stratton Intercontinental Medical Book Corp., 1973
Volume(issue)/page/year: -,253,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 18800 ug/kg
SEX/DURATION
: female 28 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 34,448,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - guinea pig
DOSE
: 18776 ug/kg
SEX/DURATION
: female 28 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
62,15,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 18776 ug/kg
SEX/DURATION
: female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
62,15,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 15 mg/kg
SEX/DURATION
: female 4-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
PARWAC Polskie Archiwum Weterynaryjne. Polish Archives of Veterinary
Medicine. (Panstwowe Wydawnictwo Naukowe, POB 391, 00251 Warsaw, Poland)
V.11951- Volume(issue)/page/year: 22,263,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 6,139,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 6,139,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 6,139,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 22 mg/kg
SEX/DURATION
: female 15-35 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 24(2),9A,1981
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MJDHDW Mukogawa Joshi Daigaku Kiyo, Shokumotsu-hen. Bulletin of Mukogawa
Women's University, Food Science Series. (Mukogawa Joshi Daigaku, 6-46,
Ikebiraki-cho, Nishinomiya, Hyogo-ken, Japan) No.191972Volume(issue)/page/year: 28,F39,1980
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1560 ug/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 74,89,1973
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
259,147,1991
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 500 nmol/L
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 295,683,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 500 nmol/L
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 295,683,1982
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Fish - not otherwise specified Leukocyte
DOSE/DURATION
: 2 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,157,1994
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 12 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1292,83,1993
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 3 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
292,83,1993
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
340,175,1996
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
22,172,1993
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
340,175,1996
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 1 ppm
REFERENCE :
JIDZA9 Jinrui Idengaku Zasshi. Journal of Human Genetics. (Nippon
Jinrui
Iden Gakkai, c/o Tokyo Ika Shika Daigaku, 1-5-45 Yushima, Bunkyo-ku,
Tokyo
113, Japan) V.11956- Volume(issue)/page/year: 20,256,1976
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 200 umol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 64,142,1970
TYPE OF TEST
TEST SYSTEM
: Cytogenetic analysis
: Human Lymphocyte
DOSE/DURATION
: 1 umol/L
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11953Volume(issue)/page/year: 26,99,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
301,267,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 600 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
281,255,1992
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
22,172,1993
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 2 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
22,172,1993
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
22,172,1993
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
47,113,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 12,97,1987
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,31,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 12,97,1987
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
24,489,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
24,489,1975
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 nmol/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 36,297,1985
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: DNA inhibition
: Rodent - mouse Cells - not otherwise specified
: 50 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,24,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11962- Volume(issue)/page/year:
41,371,1984
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
REFERENCE :
ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,
Jena DDR-6900, Ger. Dem. Rep.) V.11886- Volume(issue)/page/year:
153,69,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
290,281,1993
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 6400 ug/kg
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25,381,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 10 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,679,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 ppb
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 90,103,1979
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Mammal - cat
DOSE/DURATION
: 14784 ug/kg/12W (Continuous)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,251,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Hg)/m3; STEL 0.03 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,239,1993
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 126,390,1976
TOXICOLOGY REVIEW
JORCAI Journal of Organometallic Chemistry.
(Elsevier Sequoia SA, POB
851,
CH-1001 Lausanne l, Switzerland)
76,265,1974
V.1-
1963-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252,
CEP 04014, Sao Paulo, Brazil) V.11935- Volume(issue)/page/year:
41(7),208,1975
TOXICOLOGY REVIEW
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968-
Volume(issue)/page/year: 12,311,1975
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
42,103,1972
V.1-
1962-
Volume(issue)/page/year:
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.001 ppm (0.01 mg(Hg)/m3)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
OSHA PEL (Gen Indu):8H TWA 0.01 mg(Hg)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.01 mg(Hg)/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.01 mg(Hg)/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.01 mg(Hg)/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.01 mg(Hg)/m3;STEL 0.02 mg(Hg)/m3;Skin JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-THE PHILIPPINES:TWA 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.01 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-TURKEY:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ORGANO-air:TWA 0.01 mg/m3;STEL 0.03 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7132
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 14 (estimated)
No. of Female Employees: 5 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
METHYL NITROANILINE (4:2-)
RTECS NUMBER
: XU8227250
CHEMICAL NAME
: p-Toluidine, 2-nitroCAS REGISTRY NUMBER
: 89-62-3
LAST UPDATED
: 199710
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H8-N2-O2
MOLECULAR WEIGHT
: 152.17
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* AI3-09044
* Azoamine Red A
* Benzenamine, 4-methyl-2-nitro* 4-Methyl-2-nitroaniline
* 4-Methyl-2-nitrobenzenamine
* 2-Nitro-p-toluidine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 6,230,1954
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL NITROBENZOATE (4-)
RTECS NUMBER
: DH5775000
CHEMICAL NAME
: Benzoic acid, p-nitro-, methyl ester
CAS REGISTRY NUMBER
: 619-50-1
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H7-N-O4
MOLECULAR WEIGHT
: 181.16
WISWESSER LINE NOTATION : WNR DVO1
SYNONYMS/TRADE NAMES :
* Benzoic acid, 4-nitro-, methyl ester
* p-Carbomethoxynitrobenzene
* Methyl-p-nitrobenzoate
* Methyl 4-nitrobenzoate
* p-Nitrobenzoic acid methyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL OLEATE
RTECS NUMBER
: RK0895000
CHEMICAL NAME
: Oleic acid, methyl ester, cisCAS REGISTRY NUMBER
: 112-62-9
LAST UPDATED
: 199706
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C19-H36-O2
MOLECULAR WEIGHT
: 296.55
WISWESSER LINE NOTATION : 9U8VO1 -C
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Emerest 2801
* Emery oleic acid ester 2301
* Methyl cis-9-octadecenoate
* Methyl (Z)-9-octadecenoate
* Methyl oleate
* NSC 406282
* (Z)-9-Octadecenoic acid, methyl ester
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 54 gm/kg/45W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Skin and Appendages - tumors
REFERENCE :
AMBPBZ Acta Pathologica et Microbiologica Scandinavica, Section A:
Pathology. (Copenhagen, Denmark) V.78-89, 1970-81. For publisher
information, see ACPADQ. Volume(issue)/page/year: 82,127,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:STEL 10 ppm JAN 1993
OEL-BELGIUM:STEL 10 ppm JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83646
No. of Facilities: 2265 (estimated)
No. of Industries: 45
No. of Occupations: 43
No. of Employees: 31786 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83646
No. of Facilities: 3726 (estimated)
No. of Industries: 43
No. of Occupations: 40
No. of Employees: 36455 (estimated)
No. of Female Employees: 1254 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL ORANGE
RTECS NUMBER
CHEMICAL NAME
: DB6327000
: Benzenesulfonic acid,
p-((p-(dimethylamino)phenyl)azo)-, sodium salt
CAS REGISTRY NUMBER
: 547-58-0
LAST UPDATED
: 199710
DATA ITEMS CITED
: 16
MOLECULAR FORMULA
: C14-H14-N3-O3-S.Na
MOLECULAR WEIGHT
: 327.36
WISWESSER LINE NOTATION : WSQR DNUNR DN1&1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* C.I. 13025
* C.I. Acid Orange 52
* Diazoben
* 4-Dimethylaminoazobenzene-4'-sulphonic acid sodium salt
* p-((p-(Dimethylamino)phenyl)azo)benzenesulfonic acid sodium salt
* Eniamethyl Orange
* Gold Orange
* Helianthine
* Helianthine B
* Kca Methyl Orange
* Methyl Orange
* Methyl Orange B
* Methyloranz
* Orange 3
* Orange III
* Oranz III
* Oranz kysela 52
* Oranz methylova
* Tropaeolin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1306,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 101 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,682,1981
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,302,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,219,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,502,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,424,1981
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 4 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,528,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 150 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
152,113,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 2500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,638,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0795
No. of Facilities: 1906 (estimated)
No. of Industries: 50
No. of Occupations: 26
No. of Employees: 12071 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0795
No. of Facilities: 1874 (estimated)
No. of Industries: 37
No. of Occupations: 34
No. of Employees: 24528 (estimated)
No. of Female Employees: 3661 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; B
subtilis
rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL PENTANEDIOL (2,2,4-)
RTECS NUMBER
: SA0810000
CHEMICAL NAME
: 2,4-Pentanediol, 2-methylCAS REGISTRY NUMBER
: 107-41-5
BEILSTEIN REFERENCE NO. : 1098298
REFERENCE
: 4-01-00-02565 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 34
MOLECULAR FORMULA
: C6-H14-O2
MOLECULAR WEIGHT
: 118.20
WISWESSER LINE NOTATION : QY1&1XQ1&1
COMPOUND DESCRIPTOR
: Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,4-Dihydroxy-2-methylpentane
* Diolane
* Hexylene glycol
* Isol
* 2-Methyl pentane-2,4-diol
* 2-Methyl-2,4-pentanediol
* Pinakon
* alpha,alpha,alpha'-Trimethyltrimethylene glycol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 465 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/3/1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 465 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 82,377,1944
V.1-
1909/10-
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,777,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 93 mg
REACTION SEVERITY
: Severe
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 12-4/1970
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 50 ppm/15M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - other changes
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,312,1969
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 50 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,262,1946
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,68,1974
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >310 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 12-4/1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - renal function tests depressed
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 11,150,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3097 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,669,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1299 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,5,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Liver - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 4,142,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8560 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 13 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,777,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Liver - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 4,142,1945
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE/DURATION
: 33600 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in adrenal weight
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 12-4/1970
*** REVIEWS ***
ACGIH TLV-CL 121 mg/m3 (25 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(5),223,1985
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 25 ppm (125 mg/m3) JAN 1993
OEL-BELGIUM:STEL 25 ppm (121 mg/m3) JAN 1993
OEL-DENMARK: TWA 25 ppm (125 mg/m3), JAN1999
OEL-FINLAND:TWA 25 ppm (125 mg/m3);STEL 40 ppm (190 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 25 ppm (125 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (125 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 25 ppm (125 mg/m3);STEL 25 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEXYLENE GLYCOL-air:CL 25 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 37630
No. of Facilities: 30332 (estimated)
No. of Industries: 224
No. of Occupations: 149
No. of Employees: 373068 (estimated)
NOES - National Occupational
NOES Hazard Code - 37630
No. of Facilities: 43088
No. of Industries: 253
No. of Occupations: 167
No. of Employees: 754186
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
231390 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL PENTANONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
SA9275000
2-Pentanone, 4-methyl108-10-1
0605399
4-01-00-03305 (Beilstein Handbook Reference)
199907
54
C6-H12-O
100.18
1Y1&1V1
Tumorigen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Hexon
* Hexone
* Isobutyl-methylketon
* Isobutyl methyl ketone
* Isopropylacetone
* Ketone, isobutyl methyl
* Methyl-isobutyl-cetone
* Methylisobutylketon
* Methyl isobutyl ketone
*
*
*
*
*
*
*
*
*
*
*
Metyloizobutyloketon
4-Methyl-pentan-2-on
2-Methyl-4-pentanone
4-Methyl-2-pentanon
4-Methyl-2-pentanone
Metilisobutilchetone
4-Metilpentan-2-one
MIBK
MIK
RCRA waste number U161
Shell MIBK
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Human
DOSE/DURATION
: 200 ppm/15M
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,262,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,284,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 40 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/25/1958
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 uL/24H
REACTION SEVERITY
: Moderate
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2290 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2080 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/25/1958
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4748,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 23300 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(11),52,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 268 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,7,1961
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4748,1982
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 68900 mg/m3/3H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Cardiac - pulse rate
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4748,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1396 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9350 mg/kg/24D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(11),52,1973
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1996 ppm/6H/11D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 9,380,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
1002 ppm/6H/14W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 9,380,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35700 mg/kg/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Nutritional and Gross Metabolic - body temperature decrease
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(10),79,1988
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 410 mg/m3/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 410 mg/m3/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535383
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4210 mg/m3/6H/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572858
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1996 ppm/6H/11D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 9,380,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1002 ppm/6H/14W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 9,380,1987
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 8,310,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3000 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 8,310,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3000 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 8,310,1987
*** REVIEWS ***
ACGIH TLV-STEL 307 mg/m3 (75 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 205 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 100 ppm (410 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,126,1971
OSHA PEL (Gen Indu):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: MAK 100 ppm (400 mg/m3), JAN1999
OEL-DENMARK: TWA 25 ppm (100 mg/m3), Skin, JAN1999
OEL-FRANCE: VME 50 ppm (205 mg/m3), JAN1999
OEL-JAPAN: OEL 50 ppm (200 mg/m3), Skin, JAN1999
OEL-POLAND: MAC(TWA) 200 mg/m3, MAC(STEL) 300 mg/m3, JAN1999
OEL-SWEDEN: NGV 25 ppm (100 mg/m3), KTV 50 ppm (200 mg/m3), JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ISOBUTYL KETONE-air:10H TWA 50 ppm;STEL 75 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 37510
No. of Facilities: 42735 (estimated)
No. of Industries: 258
No. of Occupations: 149
No. of Employees: 435266 (estimated)
NOES - National Occupational
NOES Hazard Code - 37510
No. of Facilities: 47027
No. of Industries: 253
No. of Occupations: 150
No. of Employees: 612921
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
110397 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.147,26992,82
1936-
Volume(issue)/page/year:
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8704
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis studies; selected, May 1999
METHYL PHENYLACETATE
RTECS NUMBER
: AJ3175000
CHEMICAL NAME
: Acetic acid, phenyl-, methyl ester
CAS REGISTRY NUMBER
: 101-41-7
LAST UPDATED
: 199709
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C9-H10-O2
MOLECULAR WEIGHT
: 150.19
WISWESSER LINE NOTATION : 1OV1R
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzeneacetic acid, methyl ester
* Methyl benzeneacetate
* Methyl benzeneethanoate
* Methyl phenylacetate
* Methyl alpha-phenylacetate
* Methyl phenylethanoate
* Methyl alpha-toluate
* Phenylacetic acid, methyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,941,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,941,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,941,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0062
No. of Facilities: 15 (estimated)
No. of Industries: 1
No. of Occupations: 16
No. of Employees: 2279 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0062
No. of Facilities: 1786 (estimated)
No. of Industries: 33
No. of Occupations: 47
No. of Employees: 51266 (estimated)
No. of Female Employees: 19603 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL PIPERIDONE (1:2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
:
:
:
:
:
:
TO0124000
2-Piperidone, 1-methyl931-20-4
0001708
5-21-06-00398 (Beilstein Handbook Reference)
199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C6-H11-N-O
MOLECULAR WEIGHT
: 113.18
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 1-Methyl-2-piperidone
* N-Methylvalerolactam
* 2-Piperidinone, 1-methyl*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 60,1058,1971
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL PROPANE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* A 31 (hydrocarbon)
* 1,1-Dimethylethane
* 2-Methylpropane
* R 600a
* Trimethylmethane
:
:
:
:
:
:
:
:
TZ4300000
Propane, 2-methyl75-28-5
199907
14
C4-H10
58.14
1Y1&1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
: Rodent - rat
DOSE/DURATION
: 57 pph/15M
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.11981- Volume(issue)/page/year: 1,239,1982
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1041 gm/m3/2H
TOXIC EFFECTS :
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 58,74,1936
V.1-
1909/10-
*** REVIEWS ***
TOXICOLOGY REVIEW
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug
Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.11959- Volume(issue)/page/year: 18,365,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY:TWA 1000 ppm (2350 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 800 ppm (1900 mg/m3), JAN1999
OEL-SWITZERLAND:TWA 800 ppm (1900 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 600 ppm (1430 mg/m3);STEL 750 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81851
No. of Facilities: 118992 (estimated)
No. of Industries: 360
No. of Occupations: 199
No. of Employees: 1193478 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81851
No. of Facilities: 110810 (estimated)
No. of Industries: 377
No. of Occupations: 233
No. of Employees: 1795168 (estimated)
No. of Female Employees: 556159 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL PROPIOLATE
RTECS NUMBER
: UE0050000
CHEMICAL NAME
: Propiolic acid, methyl ester
CAS REGISTRY NUMBER
: 922-67-8
BEILSTEIN REFERENCE NO. : 0605462
REFERENCE
: 4-02-00-01688 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C4-H4-O2
MOLECULAR WEIGHT
: 84.08
WISWESSER LINE NOTATION : 1UU1VO1
SYNONYMS/TRADE NAMES :
* Acetylenecarboxylic acid methyl ester
* Methyl propiolate
* Propynoic acid, methyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#08364
METHYL PYRIDONE (1:2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: UV1148100
: 2(1H)-Pyridone, 1-methyl: 694-85-9
BEILSTEIN REFERENCE NO. : 0107805
REFERENCE
: 5-21-07-00109 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H7-N-O
MOLECULAR WEIGHT
: 109.14
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* 1-Methyl-2(1H)-pyridinone
* N-Methylpyridone
* 1-Methyl-2(1H)-pyridone
* 2(1H)-Pyridinone, 1-methyl*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 421 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 48,371,1976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL PYRROLIDE (1-)
RTECS NUMBER
: UY1420500
CHEMICAL NAME
: Pyrrolidine, 1-methylCAS REGISTRY NUMBER
: 120-94-5
BEILSTEIN REFERENCE NO. : 0102445
REFERENCE
: 5-20-01-00166 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C5-H11-N
MOLECULAR WEIGHT
: 85.17
WISWESSER LINE NOTATION : T5NTJ A1
SYNONYMS/TRADE NAMES :
* N-Methylpyrrolidine
* 1-Methylpyrrolidine
* N-Methyltetrahydropyrrole
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 88,82,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 88,82,1946
V.1-
1909/10-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6939
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 9 (estimated)
No. of Female Employees: 9 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL RED
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
:
:
:
:
:
:
:
DG8960000
Benzoic acid, 2-((4-dimethylamino)phenylazo)493-52-7
199701
12
C15-H15-N3-O2
269.33
WISWESSER LINE NOTATION : QVR BNUNR DN1&1
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 2-Carboxy-4'-(dimethylamino)azobenzene
* Cerven kysela 2
* Cerven methylova
* C.I. 13020
* C.I. Acid Red 2
* p-(Dimethylamino)azobenzene-o-carboxylic acid
* 4'-Dimethylaminoazobenzene-2-carboxylic acid
* o-((p-(Dimethylamino)phenyl)azo)benzoic acid
* 2-((4-Dimethylamino)phenylazo)benzoic acid
* Methyl Red
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 gm/kg/57W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
9,310,1955
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
56,249,1978
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 2 mg/disc
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of
Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan)
V.11949/50- Volume(issue)/page/year: 27,153,1976
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Unscheduled DNA synthesis
: Rodent - rat Liver
: 10 umol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,1654,1986
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 8,161,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 8,161,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82256
No. of Facilities: 2272 (estimated)
No. of Industries: 36
No. of Occupations: 20
No. of Employees: 12342 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82256
No. of Facilities: 2693 (estimated)
No. of Industries: 24
No. of Occupations: 32
No. of Employees: 39756 (estimated)
No. of Female Employees: 26156 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL SALICYLATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
VO4725000
Salicylic acid, methyl ester
119-36-8
0971516
4-10-00-00143 (Beilstein Handbook Reference)
199710
45
C8-H8-O3
152.16
QR BVO1
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* o-Anisic acid
* Benzoic acid, 2-hydroxy-, methyl ester
* Betula
* Betula oil
* Exagien
* Flucarmit
* Gaultheria oil, artificial
* Gaultheria oil
* o-Hydroxybenzoic acid, methyl ester
* 2-Hydroxybenzoic acid methyl ester
* Methylester kyseliny salicylove
* Methyl o-hydroxybenzoate
* Methyl salicylate
* Natural wintergreen oil
* Oil of wintergreen
* Synthetic wintergreen oil
* Teaberry oil
* Wintergreen oil
* Wintergreen oil, synthetic
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986
-,668,1986
Volume(issue)/page/year:
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100%
REACTION SEVERITY
: Severe
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100%
REACTION SEVERITY
: Severe
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 101 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - nausea or vomiting
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
193,772,1937
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 1329 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Blood - hemorrhage
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81.
publisher
information, see JTCTDW. Volume(issue)/page/year: 6,189,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 228 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
For
Gastrointestinal - nausea or vomiting
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn
St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.1001960Volume(issue)/page/year: 69,37,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046) V.11926- Volume(issue)/page/year:
28,475,1953
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 355 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - nausea or vomiting
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
193,772,1937
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 1480 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - nausea or vomiting
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
193,772,1937
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 506 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,961,1989
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 522 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 887 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 132,207,1961
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 2100 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,821,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed.,
New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year:
2,1897,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,63,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 71400 mg/kg/17W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,576,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 546 gm/kg/2Y-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Kidney, Ureter, Bladder - changes in kidney weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,576,1963
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 57(7-8),28,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 85200 mg/kg/10W-C
TOXIC EFFECTS :
Musculoskeletal - other changes
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,576,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 40800 mg/kg/59D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,576,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 330 gm/kg/90D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,576,1963
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 36450 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,755,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 11,381,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 11,381,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 35,315,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 35,315,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 1750 mg/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,421,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 5250 mg/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,421,1983
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/disc
REFERENCE :
JNUDAT Journal of Nihon University School of Dentistry. (Nihon
University
School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101,
Japan)
V.11958- Volume(issue)/page/year: 34,183,1992
*** REVIEWS ***
TOXICOLOGY REVIEW
DICPBB Drug Intelligence and Clinical Pharmacy.
(POB 42435, Cincinnati,
OH
45242)
V.3-
1969-
Volume(issue)/page/year: 9,350,1975
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.11955Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology.
(Palo Alto, CA)
V.1-15, 1961-75.
For
publisher information, see ARPTDI.
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
Volume(issue)/page/year: 5,447,1965
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 15,121,1976
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,747,1989
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 48320
No. of Facilities: 15668 (estimated)
No. of Industries: 138
No. of Occupations: 80
No. of Employees: 105490 (estimated)
NOES - National Occupational
NOES Hazard Code - 48320
No. of Facilities: 30724
No. of Industries: 193
No. of Occupations: 134
No. of Employees: 454822
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
134722 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL STEARATE
RTECS NUMBER
: WI4460000
CHEMICAL NAME
: Stearic acid, methyl ester
CAS REGISTRY NUMBER
: 112-61-8
BEILSTEIN REFERENCE NO. : 1786213
REFERENCE
: 4-02-00-01216 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C19-H38-O2
MOLECULAR WEIGHT
: 298.57
WISWESSER LINE NOTATION : 17VO1
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Emery 2218
* Kemester 9018
* Metholene 2218
* Methyl octadecanoate
* Methyl stearate
* Octadecanoic acid, methyl ester
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
5200 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
32,880,1972
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5200 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
30,1037,1970
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3864
No. of Facilities: 151 (estimated)
No. of Industries: 9
No. of Occupations: 11
No. of Employees: 1923 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3864
No. of Facilities: 1248 (estimated)
No. of Industries: 20
No. of Occupations: 34
No. of Employees: 52439 (estimated)
No. of Female Employees: 37247 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL TOLUENESULFONATE (4-)
RTECS NUMBER
: XT7000000
CHEMICAL NAME
: p-Toluenesulfonic acid, methyl ester
CAS REGISTRY NUMBER
: 80-48-8
BEILSTEIN REFERENCE NO. : 0609209
REFERENCE
: 4-11-00-00247 (Beilstein Handbook Reference)
LAST UPDATED
: 199707
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C8-H10-O3-S
MOLECULAR WEIGHT
: 186.24
WISWESSER LINE NOTATION : 1OSWR D1
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzenesulfonic acid, 4-methyl-, methyl ester
* Methylester kyseliny p-toluensulfonove
* Methyl p-methylbenzenesulfonate
* Methyl 4-methylbenzenesulfonate
* Methyl-p-toluenesulfonate
* Methyl toluene-4-sulfonate
* Methyl tosylate
* Methyl p-tosylate
* p-Toluolsulfonsaeure methyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1067,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1067,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 341 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1067,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Subcutaneous
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
74,241,1970
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg/2Y
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
74,241,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,576,1968
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg/54W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
74,241,1970
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: Sex chromosome loss and nondisjunction
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
198,73,1988
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 11 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
198,73,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL UNDECANOATE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
SYNONYMS/TRADE NAMES :
* Methyl undecanoate
* Methyl n-undecanoate
YQ2573000
Undecanoic acid, methyl ester
1731-86-8
1762129
3-02-00-00858 (Beilstein Handbook Reference)
199701
2
C12-H24-O2
200.36
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RESJAS Journal of the Reticuloendothelial Society. (1964) (Res: Journal
of
the Reticuloendothelial Society, New York) V.1(1)-14(6), 1964-73.
Volume(issue)/page/year: 3,250,1966
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL VALERATE
RTECS NUMBER
: YV7750500
CHEMICAL NAME
: Valeric acid, methyl ester
CAS REGISTRY NUMBER
: 624-24-8
BEILSTEIN REFERENCE NO. : 1741905
REFERENCE
: 4-02-00-00871 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C6-H12-O2
MOLECULAR WEIGHT
: 116.18
WISWESSER LINE NOTATION : 4VO1
SYNONYMS/TRADE NAMES :
* Methyl pentanoate
* Methyl valerate
* Methyl n-valerate
* Methyl valerianate
* Pentanoic acid, methyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6600 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,88,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 6600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYL VANILLYLNONENAMIDE (8,6-)
RTECS NUMBER
: RA8530000
CHEMICAL NAME
: 6-Nonenamide,
N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-,
(E)CAS REGISTRY NUMBER
: 404-86-4
BEILSTEIN REFERENCE NO. : 2816484
REFERENCE
: 4-13-00-02588 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 23
MOLECULAR FORMULA
: C18-H27-N-O3
MOLECULAR WEIGHT
: 305.46
WISWESSER LINE NOTATION : 1OR BQ E1MV5U1Y1&1
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Capsaicin
* Capsaicine
* N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide
* trans-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide
* (E)-8-Methyl-N-vanillyl-6-nonenamide
* trans-8-Methyl-N-vanillyl-6-nonenamide
* NCI-C56564
* 6-Nonenamide, 8-methyl-N-vanillyl-, (E)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
47200 ug/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAHOA3 Yakhak Hoe Chi. Journal of the Pharmaceutical Society. (Taehan
Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
Korea) V.11956(?)- Volume(issue)/page/year: 25(3),101,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >512 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9000 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAHOA3 Yakhak Hoe Chi. Journal of the Pharmaceutical Society. (Taehan
Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
Korea) V.11956(?)- Volume(issue)/page/year: 25(3),101,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intramuscular
: Rodent - mouse
DOSE/DURATION
: 7800 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >218 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 48A,60,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1100 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: >120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 18,215,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/2W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 5,99,1985
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3318 mg/kg/5W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens
907,
Greece) V.11981- Volume(issue)/page/year: 4,117,1984
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,881,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 7500 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,881,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1800 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,881,1985
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 93120 ug/kg/32D (Intermittent)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
345,105,1995
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
48,109,1989
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1996: Capsaicin, 5041
METHYL VINYL KETONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: EM9800000
: 3-Buten-2-one
: 78-94-4
LAST UPDATED
: 199901
DATA ITEMS CITED
: 18
MOLECULAR FORMULA
: C4-H6-O
MOLECULAR WEIGHT
: 70.10
WISWESSER LINE NOTATION : 1V1U1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Acetone, methylene* Acetyl ethylene
* 3-Butene-2-one
* Butenone
* delta(sup 3)-2-Butenone
* Ketone, methyl vinyl
* Methylene acetone
* Methyl-vinyl-cetone
* Methylvinylketon
* Methylvinyl ketone
* gamma-Oxo-alpha-butylene
* Vinyl methyl ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(10),4,1993
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,88,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
(V/O
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555304
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 23300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(10),4,1993
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,88,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZolH## Personal Communication from H. Zollner, Institut fur Biochemie,
Der
Universitat, Gras, Oct. 23, 1975 Volume(issue)/page/year: 23OCT1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555304
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Intraperitoneal
Rodent - guinea pig
15 mg/kg
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555304
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3900 ppb/6H/9D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - acute pulmonary edema
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555304
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 7800 ppb/6H/9D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555304
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 7800 ppb/6H/9D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555304
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 250 umol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,305,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 nmol/tube
REFERENCE :
CRTOEC Chemical Research in Toxicology. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57/36, West End Station, Washington,
DC
20037) V.11988- Volume(issue)/page/year: 4,50,1991
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 125 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
412,17,1998
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYL VIOLET 2B
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Aizen Methyl Violet
* Basic Violet 1
* Basic Violet K
* Basonyl Violet 600
* C Ext. Violet 5
* C.I. 42535
* C.I. Basic Violet 1
* Gentian Violet B
* Methyl Violet
* Methyl Violet 2B
:
:
:
:
:
:
GC8425000
C.I. Basic Violet
8004-87-3
199710
13
Agricultural Chemical
Mutagen
*
*
*
*
*
*
*
*
*
*
*
Methyl Violet 6B
Methyl Violet BB
Methyl Violet FN
Methyl Violet N
Methyl-violett
Paris Violet R
Pyoktanin Blue
Pyoktaninum coeruleum
Violet methylova
Violet powder H 2503
Violet zasadita 1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 413 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0382-0436
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 975 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(4),102,1978
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 1,5,1951
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
6 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 1,5,1951
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1663 mg/kg/17W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Liver - changes in liver weight
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(4),102,1978
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 110 mg/m3/2H/44D-I
TOXIC EFFECTS :
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),54,1963
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 320 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,21,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 ug/L
REFERENCE :
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii
(VINITI).
All-Union Institute of Scientific and Technical Information. (Moscow,
USSR)
Use information broker to obtain publications. Volume(issue)/page/year:
#542-84
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2194
No. of Facilities: 2184 (estimated)
No. of Industries: 29
No. of Occupations: 41
No. of Employees: 32784 (estimated)
NOES - National Occupational
NOES Hazard Code - M2194
No. of Facilities: 17053
No. of Industries: 158
No. of Occupations: 97
No. of Employees: 302502
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
29239 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYLACETANILIDE (2-)
RTECS NUMBER
: AN2900000
CHEMICAL NAME
: o-Acetotoluidide
CAS REGISTRY NUMBER
: 120-66-1
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C9-H11-N-O
MOLECULAR WEIGHT
: 149.21
WISWESSER LINE NOTATION : 1VMR B1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Acetamide, N-(2-methylphenyl)* Acetyl-o-toluidine
* o-Methylacetanilide
* 2-Methylacetanilide
* 2'-Methylacetanilide
* N-(2-Methylphenyl)acetamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD - Lethal dose
Intraperitoneal
Rodent - rat
>500 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,9,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,20,1971
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
NTPTB* NTP Technical
Bldg.
3A-06, 7910 Woodmont
JAN1982
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 1 mg/plate
Bulletin.
(National Toxicology Program, Landow
Ave., Bethesda, MD 20205)
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 47 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
137,39,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYLACETANILIDE (3'-)
RTECS NUMBER
: AN2875000
CHEMICAL NAME
: m-Acetotoluidide
CAS REGISTRY NUMBER
: 537-92-8
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C9-H11-N-O
MOLECULAR WEIGHT
: 149.21
WISWESSER LINE NOTATION : 1VMR C1
SYNONYMS/TRADE NAMES :
* Acetamide, N-(3-methylphenyl)* 3-Acetamidotoluene
*
*
*
*
*
*
*
*
*
Aceto-m-aminotoluene
Acetotoluide
N-Acetyl-m-toluidine
m-Methylacetanilide
3-Methylacetanilide
3'-Methylacetanilide
N-(3-Methylphenyl)acetamide
m-Tolylacetamide
N-m-Tolylacetamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,20,1971
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
METHYLACETOPHENONE (4'-)
RTECS NUMBER
: AM9463000
CHEMICAL NAME
: Acetophenone, 4'-methylCAS REGISTRY NUMBER
: 122-00-9
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C9-H10-O
MOLECULAR WEIGHT
: 134.19
WISWESSER LINE NOTATION : 1VR D1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* p-Acetyltoluene
* Ethanone, 1-(4-methylphenyl)* Melilotal
* p-Methylacetophenone
* 4'-Methylacetophenone
* 1-Methyl-4-acetylbenzene
* 1-(4-Methylphenyl)ethanone
* Methyl p-tolyl ketone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100%
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,933,1974
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,933,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,933,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83203
No. of Facilities: 38 (estimated)
No. of Industries: 2
No. of Occupations: 27
No. of Employees: 5690 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83203
No. of Facilities: 325 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 3426 (estimated)
No. of Female Employees: 2144 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYLALANINE NITRILE (N:BETA-)
RTECS NUMBER
: TZ4910000
CHEMICAL NAME
: Propanenitrile, 3-(methylamino)CAS REGISTRY NUMBER
: 693-05-0
BEILSTEIN REFERENCE NO. : 1699160
REFERENCE
: 3-04-00-01264 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C4-H8-N2
MOLECULAR WEIGHT
: 84.14
SYNONYMS/TRADE NAMES :
* AI3-26057
* N-(beta-Cyanoethyl)methylamine
* N-(2-Cyanoethyl)methylamine
* (2-Cyanoethyl)methylamine
* 3-(Methylamino)propanenitrile
* beta-Methylaminopropionitril
* beta-(Methylamino)propionitrile
* 3-(Methylamino)propionitrile
* 3-(N-Methylamino)propionitrile
* Propionitrile, 3-(methylamino)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2260 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2260 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,
Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg/5D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570990
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYLAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Aminomethane
* Carbinamine
* Mercurialin
* Methanamine
* Methylamine
* Methylaminen
* Metilamine
* Metyloamina
* Monomethylamine
:
:
:
:
:
:
:
:
:
PF6300000
Methylamine
74-89-5
199907
44
C-H5-N
31.07
Z1
Mutagen
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis.
(Munksgaard International Pub., c/o Publications Expediting Inc., 200
Meacham Ave., Elmont, NY 11003) V.11975- Volume(issue)/page/year:
6,140,1980
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.11989Volume(issue)/page/year: 2,29,1990
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 448 ppm/2.5H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
JEBIDP Journal of Environmental Biology. (Academy of Environmental
Biology,
India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.11980- Volume(issue)/page/year: 13,273,1992
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
ROUTE OF EXPOSURE
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,81,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,949,1989
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2400 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 14,80,1975
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 750 ppm/6H/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - changes in testicular weight
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.11989Volume(issue)/page/year: 2,29,1990
** MUTATION DATA **
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 ug/m3
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),7,1981
(V/O
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 3 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,285,1986
*** REVIEWS ***
ACGIH TLV-STEL 19 mg/m3 (15 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 6.4 mg/m3 (5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office
Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.11924Volume(issue)/page/year: 9,389,1931
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 10 ppm (12 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,156,1971
OSHA PEL (Gen Indu):8H TWA 10 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 10 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 10 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 10 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (12 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 10 ppm (12 mg/m3), JAN1999
OEL-BELGIUM:TWA 10 ppm (13 mg/m3) JAN 1993
OEL-DENMARK: TWA 10 ppm (12 mg/m3), Skin, JAN1999
OEL-FINLAND:STEL 10 ppm (12 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 10 ppm (12 mg/m3) JAN 1993
OEL-JAPAN: OEL 10 ppm (13 mg/m3), JAN1999
OEL-JAPAN:TWA 10 ppm (13 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (12 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (12 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 5 mg/m3, MAC(STEL) 15 mg/m3, JAN1999
OEL-SWEDEN: NGV 10 ppm (13 mg/m3), KTV 20 ppm (25 mg/m3), Skin, JAN1999
OEL-RUSSIA:TWA 10 ppm;STEL 1 mg/m3;Skin JAN 1993
OEL-SWEDEN:TWA 10 ppm (13 mg/m3);STEL 20 ppm (25 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (12 mg/m3);STEL 20 ppm (24 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (12 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYLAMINE-air:10H TWA 10 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46470
No. of Facilities: 175 (estimated)
No. of Industries: 5
No. of Occupations: 9
No. of Employees: 1098 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46470
No. of Facilities: 197 (estimated)
No. of Industries: 6
No. of Occupations: 24
No. of Employees: 10890 (estimated)
No. of Female Employees: 1411 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
OSHA ANALYTICAL METHOD #40
METHYLAMINE HYDROCHLORIDE
RTECS NUMBER
: PA0603000
CHEMICAL NAME
: Methanamine, hydrochloride
CAS REGISTRY NUMBER
: 593-51-1
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C-H5-N.Cl-H
MOLECULAR WEIGHT
: 67.53
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Methylamine, hydrochloride
* Methylammonium chloride
* Monomethylammonium chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.11989Volume(issue)/page/year: 2,29,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 610 mg/kg/5D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 47,479,1996
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4270
No.
No.
No.
No.
of
of
of
of
Facilities: 7 (estimated)
Industries: 1
Occupations: 1
Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYLAMINOPHENOL HEMISULFATE (4-)
RTECS NUMBER
: SL8650000
CHEMICAL NAME
: Phenol, p-methylamino-, sulfate (salt)
CAS REGISTRY NUMBER
: 55-55-0
LAST UPDATED
: 199710
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C7-H9-N-O.1/2H2-O4-S
MOLECULAR WEIGHT
: 219.23
WISWESSER LINE NOTATION : QR DM1 &S-O4
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Armol
* Elon (developer)
* Genol
* Graphol
* Metatyl
* Methyl-p-aminophenol sulfate
* p-Methylaminophenolsulfate
* Metol
* Phenol, p-(methylamino)-, sulfate (2:1) (salt)
* Photol
* Pictol
* Planetol
* Rhodol
* Verol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 705 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),87,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 565 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 769 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),87,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1585 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),87,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9350 mg/kg/11D-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in spleen
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6600 mg/kg/94D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Endocrine - changes in spleen weight
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4300 mg/kg/61D-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),87,1984
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 167 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81914
No. of Facilities: 9601 (estimated)
No. of Industries: 85
No. of Occupations: 47
No. of Employees: 40485 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81914
No. of Facilities: 6348 (estimated)
No. of Industries: 37
No. of Occupations: 34
No. of Employees: 43146 (estimated)
No. of Female Employees: 24720 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
METHYLANILINE
RTECS NUMBER
: BY4550000
CHEMICAL NAME
: Aniline, N-methylCAS REGISTRY NUMBER
: 100-61-8
LAST UPDATED
: 199907
DATA ITEMS CITED
: 31
MOLECULAR FORMULA
: C7-H9-N
MOLECULAR WEIGHT
: 107.17
WISWESSER LINE NOTATION : 1MR
SYNONYMS/TRADE NAMES :
* Anilinomethane
* Benzenamine, N-methyl* (Methylamino)benzene
*
*
*
*
*
*
*
*
*
*
N-Methylaminobenzene
Methylaniline
N-Methylaniline
N-Methylbenzenamine
Methylphenylamine
N-Methylphenylamine
Monomethylaniline
N-Monomethylaniline
Monomethyl aniline
N-Phenylmethylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 24 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,1,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,1,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 24 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,1,1949
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Oral
: Rodent - guinea pig
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington,
DC)
Volume(issue)/page/year: 271,16,1941
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington,
DC)
Volume(issue)/page/year: 271,16,1941
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 ug/m3/24H/14W-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Liver - liver function tests impaired
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 34(3),7,1969
(V/O
*** REVIEWS ***
ACGIH TLV-TWA 2.2 mg/m3 (0.5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2 ppm (9 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,174,1971
OSHA PEL (Gen Indu):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 2 ppm (9 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 0.5 ppm (2 mg/m3), Skin, JAN1999
OEL-AUSTRALIA:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 0.5 ppm (2.2 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 0.5 ppm (2.25 mg/m3), Skin, JAN1999
OEL-GERMANY:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 ppm (2 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.5 ppm (2.2 mg/m3);STEL 1.0 ppm;Skin JAN 1993
OEL-TURKEY:TWA 2 ppm (9 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 2 mg/m3, JAN1999
OEL-UNITED KINGDOM:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MONOMETHYL ANILINE-air:10H TWA 0.5 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3740
No. of Facilities: 82 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 82 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Monomethylaniline, 3511
METHYLANISOLE (3-)
RTECS NUMBER
: BZ8778000
CHEMICAL NAME
: Anisole, m-methylCAS REGISTRY NUMBER
: 100-84-5
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H10-O
MOLECULAR WEIGHT
: 122.18
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzene, 1-methoxy-3-methyl* m-Cresol methyl ether
* m-Cresyl methyl ether
* m-Methoxytoluene
* 3-Methoxytoluene
* m-Methylanisole
* 3-Methylanisole
* Me