CURRENT TS ALLIANCE RESEARCH GRANT RECIPIENTS
Currently, the research portfolio of the TS Alliance focuses on basic, translational and clinical
research in the areas of tuberin and hamartin basic function, epilepsy, angiogenesis, genetics,
renal function, and behavior and cognition, as well as support for TSC and LAM clinical trials.
Grant Awards -- FY 2009
Sandra Dabora, M.D., Ph.D.
Brigham & Women’s Hospital, Boston, MA
Supplement for TSC Preclinical Studies and Clinical Trials
TS Alliance Supplemental Funding Award
Petrus de Vries, MBChB, MRCPsych, Ph.D.
Cambridge University & Society for the Study of Behavioral Phenotypes (SSBP), Cambridge,
UK
Listening to Genetic Disorders: The Etiology and Treatment of Neurodevelopmental
Disorders
TS Alliance Conference Grant
June Goto, Ph.D.
Sponsor: David Kwiatkowski, M.D., Ph.D.
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Generation and Characterization of Genetic Models for Cortical Tubers
Postdoctoral Fellowship Award
Johnathan Lipton, M.D., Ph.D.
Sponsor: Mustafa Sahin, M.D., Ph.D.
Children’s Hospital, Boston, and Harvard Medical School, Boston, MA
Toward the Molecular Basis for Sleep Disorders in Tuberous Sclerosis Complex: The
Circadian Link
Postdoctoral Fellowship Award
Guy McKhann, II, M.D.
Columbia University Medical Center, New York City, NY
Aberrant Astrocytic Control of Neuronal Excitability in Tuberous Sclerosis: A
Potential Therapeutic Target in TSC Epileptic Syndrome
TSC Innovator Innovator Award
John-Claude Platel, Ph.D.
Sponsor: Angelique Bordey, Ph.D.
Yale University School of Medicine, New Haven, CT
Contributions of Neonatal Neural Progenitors to TSC Lesions
Postdoctoral Fellowship Award
Wei Qin, Ph.D.
Sponsor: David Kwiatkowski, M.D., Ph.D.
Brigham and Women’s Hospital, Harvard School of Medicine, Boston, MA
High Throughput Sequencing for Mutation Identification in TSC Genes
Postdoctoral Fellowship Award
Howard Weiner, M.D.
New York University Medical Center, New York, NY
Defining the Epileptogenic Zone in Tuberous Sclerosis Complex: Microelectrode
Recordings in Children with Intractable Epilepsy and TSC
TSC Innovator Award
Raymond Yeung, M.D.
University of Washington, Seattle, WA
Glucose Restriction in TSC
TSC Innovator Award
Yonghao Yu, Ph.D.
Sponsor: John Blenis, Ph.D.
Harvard Medical School, Boston, MA
Characterization of the mTOR Signaling Pathways Using Quantitative Mass
Spectrometry
Postdoctoral Fellowship Award
Grant Awards -- FY 2008
Linda DiBella, Ph.D.
Sponsor: Dr. Sun, Ph.D.
Yale University, New Haven, CT
Investigating a Link Between the Cilium and the TSC/mTOR Pathway
Postdoctoral Fellowship Award
Cheryl Doughty, Ph.D.
Sponsor: David Kwiatkowski, M.D., Ph.D.
Brigham & Women’s Hospital, Boston, MA
Investigation of TSC2 Missense Mutations
Postdoctoral Fellowship Award
Kevin Ess, M.D., Ph.D.
Vanderbilt University, Nashville, TN
Role of the Tuberin GAP Domain in Neural Progenitor Cells
Junior Investigator Award
Elizabeth Petri Henske, M.D.
Fox Chase Cancer Center, Philadelphia, PA
Roles of Tuberin (TSC2) and Rheb in Cystic Kidney Disease
PKD/TSC Research Award co-funded by the TS Alliance and the PKD Foundation
Arnold Kristoff, M.D.
McGill University, Montreal, Quebec, Canada
mTOR-containing Protein Complexes in the Pathogenesis of Tuberous Sclerosis
NIH Grant Award, Co-Funded by the National Cancer Institute, National Institutes of Health
and the TS Alliance
Shao-Jun Tang, Ph.D.
University of California, Irvine, CA
Roles of TSC2 in Regulation of Dendritic Protein Synthesis and Synaptic Plasticity
Junior Investigator Award
Cheryl Walker, Ph.D.
M.D. Anderson Cancer Center, University of Texas, Smithville, TX
C-SRC Regulation of the Functional PKD-1 TSC2 Interaction
PKD/TSC Research Award co-funded by the TS Alliance and the PKD Foundation
Michael Wong, M.D., Ph.D.
Washington University, St. Louis, MO
Rational Therapy for Neurological Manifestations in a Mouse Model of TSC
Senior Investigator Award
Grant Awards -- FY 2007
Tristan Sands
Sponsor: Arnold Kriegstein, M.D., Ph.D.
University of California, San Francisco, San Francisco, CA
Role of Tuberin in Cortical Neuron Migration
Predoctoral Award
Katrin Duevel, Ph.D.
Sponsor: Brendan Manning, Ph.D.
Harvard School of Public Health, Boston, MA
Therapeutic Potential Stemming from Defects in Cell Survival, Signaling and
Bioenergetics in TSC Cells and Tumors
Postdoctoral Fellowship Award
David Kwiatkowski, M.D., Ph.D. and Amy Farber, Ph.D.
Brigham & Women’s Hospital and Harvard, Boston, MA Boston
LAM/TSC Seminar Series
Conference Grant Award
Elizabeth Petri Henske, M.D.
Fox Chase Cancer Center, Philadelphia, PA
Mechanisms of Renal Tumorigenesis in Tuberous Sclerosis
Senior Investigator Award; Supplement to grant from NIDDK
Frank McCormack, M.D. & Bruce Trapnell, M.D.
University of Cincinnati, Cincinnati, OH
MILES Trial
TS Alliance Rothberg Courage Award
Grant Awards -- FY 2006
Kit-Sing Au, Ph.D.
University of Texas Medical School at Houston, Houston, TX
Development of New Molecular Testing for the TSC1 and TSC2 Genes
Junior Investigator Award
Joseph Bateman, Ph.D.
King’s College, London, UK
Regulation of Neuronal Differentiation by TSC in Drosophila
Junior Investigator Award
Sandra Dabora, M.D., Ph.D.
Brigham & Women's Hospital, Boston, MA
Supplement for TSC Multicenter Trial
Senior Investigator Award
Jixin Dong, Ph.D.
Sponsor: DJ Pan, Ph.D.
Johns Hopkins University, Baltimore, MD
Probing TSC1/TSC2 Protein Complex In Vivo
Postdoctoral Fellowship Award
Do-Hyung Kim, Ph.D.
University of Minnesota, Minneapolis, MN
Molecular Dissection of the Rheb-mTOR Signaling Pathway Activated in Tuberous
Sclerosis Complex
Junior Investigator Award
Lutz Kockel, Ph.D.
Sponsor: Norbert Perrimon, Ph.D.
Harvard Medical School, Boston, MA
Identification of Rheb-GEFs and Rheb Effectors by RNAi Screens in Drosophila
Postdoctoral Fellowship Award
Shaowei Li, M.D., Ph.D.
Uniformed Services University of the Health Sciences, Bethesda, MD
Response of Tuberous Sclerosis Skin Tumors to Rapamycin
Junior Investigator Award
Lynsey Meikle
Sponsor: David Kwiatkowski, M.D., Ph.D.
Brigham & Women’s Hospital, Boston, MA
TSC Translational Research Training Award
Predoctoral Award
Sue Povey, M.B., BChir, MD
University College London, London, UK
TSC1 and TSC2 Variation Database
Senior Investigator Award
Victoria Robb, Ph.D.
Sponsor: Elizabeth Petri Henske, M.D.
Fox Chase Cancer Center, Philadelphia, PA
Is Activation of Rheb or Rheb-like Protein Sufficient for Tumorigenesis in TSC?
Postdoctoral Fellowship Award
Mustafa Sahin, M.D., Ph.D.
Children’s Hospital, Boston, MA
Neuronal Connectivity in TSC2-Deficient Mice
Junior Investigator Award
Xi-Long Zheng, M.D., Ph.D.
University of Calgary, Calgary, Canada
The Role of Tuberin in Vascular Smooth Muscle Cells
Junior Investigator Award