2010 Westlake International Medicine Conference- Translational Medicine Introduction: Following the success of "Westlake International Conference on Personalized Medicine" in May 2009, Zhejiang California International NanoSystems Institute (ZCNI) and the National Key Lab for Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, Zhejiang University School of Medicine will hold the "2010 Westlake International Conference on Translational Medicine" on June 24th-26th, 2010. The conference is chaired by Prof. Lanjuan Li, member of the Chinese Academy of Engineering, and Dr. David DeMarini of US Environmental Protection Agency. This Conference aims to build an exchange platform for bio-medical research and clinical practices of translational medicine from a high and multi-perspective viewpoint regarding the current situation and future trends of medical development both at home and abroad, as well the role of China in the international community of translational medicine. The conference will consist of four themes: "Environment and Health", "Biomarkers", "Stem Cells", and "Antibody and Medicine." It will offer scientists, clinicians, medical practitioners and specialists, students, R&D experts and patients the opportunity to meet and discuss the latest breakthroughs and advances in the field of translational medicine. Date: Jun. 24th-26th, 2010 Venue: Run Run Shaw Science and Technology Museum at Yuquan Campus, Zhejiang University, 38, Zheda Road, Hangzhou, China Theme 1: Environment and Health Chair: Takehiko Nohmi, PhD, Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan Co-Chair: Jun Yang, PhD, Professor, Deputy Director, Zhejiang California International NanoSystems Institute (ZCNI) Many environmental factors are known to affect human bodies and may cause various diseases. For example, certain chemical pollutants can cause tumors; whereas air particulate matters are associated with cardiovascular diseases. Thus, developing new technologies and methods to detect such environmental hazardous factors, exploring the molecular mechanisms of the effects of environmental factors on the organism have scientific significance on the prevention and treatment of various diseases caused by these environmental factors. The key issues and hot topics of the environmental health research will be the main subjects of this session. A group of prominent guest speakers will join this session, including Dr. David Demarini from U.S. Environmental Protection Agency (EPA) and former President of the International Environmental Mutagen Society. Theme 2: Biomarkers Chair: Biaoyang Lin, PhD, Professor, Principle Investigator of the System Biology Platform of ZCNI The session on biomarkers will be dedicated to all areas of biomarker research from cancers to infectious diseases. The conference will bring together pharmaceutical and diagnostic companies, medical center, hospitals and academic institutions to discuss recent biomarker discoveries using advanced proteomics and genomics technologies including the next-generation sequencing technologies, biomarker assay development after discovery, and clinical validations. The sessions will cover the following topics: Biomarker discovery using advanced proteomics and genomics technologies; Biomarkers for personalized medicine including patient selection and monitoring response to therapy Biomarkers in translational medicine; Biomarker assay development; and Clinical validation of biomarkers. Theme 3: Stem Cells Chair: Jian-an Wang, MD Director and Chief of Cardiology, second Affiliated Hospital, Zhejiang University School of Medicine Co-Chair: Chunsheng Xiang, MD Qiushi Chair Professor of Zhejiang University, Professor of National Key laboratory for Infectious Disease Diagnosis and Treatment Stem cells are extraordinary types of cells that have the ability to self-renew for long periods of time and to differentiate into specialized cells under appropriate physiological or experimental conditions. Both basic and clinical research of stem cells has recently provided new approaches for the treatment of a number of diseases as well as tissue/organ injuries, including cardiovascular, neurological and musculoskeletal diseases, diabetes and hematopoietic disorders. The goals of this meeting are to present the most current research into the cellular and molecular biology of stem cells and their clinical applications. It will bring together key investigators at the forefront of stem cell research in the areas of self-renewal and tissue diversification, the stem cell niche, and stem cell therapy, to discuss the biological and clinical significance of normal and malignant stem cell function. Topics that will be explored in this theme are the regulation of stem cell self-renewal in normal stem cells, cellular reprogramming mechanisms, new markers for stem cells and clinical applications of stem cells. Theme 4: Antibody and Medicine Chair: Zhenping Zhu, PhD, Vice President of Novartis Biologics Co-Chair: Benjamin Hua, PhD, President of Avalon BioSciences, Adjunct Professor of ZCNI With the great success rate and number of blockbuster antibody drugs in the marketplace, monoclonal antibodies have recently become a new class of medicine for treating many diseases such as cancer, infectious diseases and inflammatory diseases. Such phenomenon is largely due to the development of antibody humanization and fully human antibody technologies. In this conference, new developments of antibody technologies, clinical applications, antibody productions, as well as IP issues will be presented and discussed. Conference Sponsors: --Zhejiang California International NanoSystems Institute (ZCNI) --National Key Laboratory for Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, Zhejiang University School of Medicine Conference Organizing Committee: Chair: Lanjuan Li, MD, Professor Member, Chinese Academy of Engineering; Chair, CAST of Zhejiang Province; Director, National Key Laboratory for Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, Zhejiang University School of Medicine David DeMarini, PhD Genetic Toxicologist, Scientist, US Environmental Protection Agency(EPA), Chief Editor, “Mutation Research-Reviews in Mutation Research” Executive Chair: Jun Yang, PhD, Professor Deputy Director of Zhejiang California International NanoSystems Institute (ZCNI) Executive Members: Biaoyang Lin, PhD, Principle Investigator of the System Biology Platform, ZCNI Chunsheng Xiang, PhD Qiushi Chair Professor of Zhejiang University, Professor of National Key Laboratory for Infectious Disease Diagnosis and Treatment Benjamin Hua, PhD, CEO of Avalon BioSciences, Ltd., Adjunct Professor of ZCNI Confirmed Speakers of the conference: David M. DeMarini, PhD Genetic Toxicologist, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle, North Carolina David J. Chen, PhD Professor, Radiation Oncology, Southwestern Medical School of Texas Daru Lu, PhD Institute of Genetics, College of Life Sciences, Fudan University, Shanghai, China Frank F. Chen, PhD Scientist, Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California Guoliang Yu, PhD Chairman and CEO, Epitomics, Inc., California, USA Hongbing Shen, PhD School of Public Health, Nanjing Medical University, Nanjing, China James Zhu, JD, MBA, PhD Partner, Perkins Coie, LLC, Los Angeles, USA Jaume Pons, PhD Vice President and CSO, Rinat Pharmaceuticals, Pfizer, USA Joshua M. Hare, M.D., FACC, FAHA Louis Lemberg Professor and Founding Director, Interdisciplinary Stem Cell Institute (ISCI), School of Medicine, University of Miami Miller Joe Zhou, PhD Visiting Professor, Peking University, CEO, Genor BioPharma Co. Wison Group. Kerry Blanchard, PhD VP, Eli Lilly China Lanjuan Li, MD Member, Chinese Academy of Engineering Director, National Key Laboratory for Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, Zhejiang University School of Medicine Larry Witte, PhD VP, ImClone Systems, Inc., USA Mark Sussman, PhD Professor of Biology, Key Investigator, Heart Research Institute, San Diego State University Matthew Tirrell, PhD Arnold and Barbara Silverman Professor and Chair, Department of Bioengineering, University of California, Berkeley Mercedes A. Walton, PhD Chairman and Chief Executive Officer, Cryo-Cell International, Inc. Michael Berens, PhD Director, Cancer and Cell Biology Division, Head, Brain Tumor Research Lab, Translational Genomics Research Institute (TGen) Odunsi, Kunle, MD, PhD Professor & Research Program Director, Division of Gynecologic Oncology, Co-Leader, Tumor Immunology and Immunotherapy Program, Roswell Park Cancer Institute Peter Luo, PhD Director, Vaccines and Biological Research, Merck Sepideh Arbabi Bidgoli, PhD Associate Prof. of Toxicology & Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS) Shuseng Zheng, MD Member, Chinese Academy of Engineering President, First Affiliated Hospital, Zhejiang University School of Medicine Susan Dillion, PhD Vice President, Global Therapeutic Area Head, J&J Pharmaceuticals R&D, USA Takehiko Nohmi, PhD Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan Takashi Yagi, PhD Environmental Genetics Laboratory, Frontier Science Innovation Center, Osaka Prefecture University William M. Grady. MD Section Chief of Medicine, Gastroenterology, School of Medicine, University of Washington Medical Center, Associate member of Fred Hutchinson Cancer Research Center Young R. Seo, PhD, Associate Professor, Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Korea, Editor-in-Chief of Cancer Prevention Research, Associate Editor of Molecular and Cellular Toxicology, Board Editor of Mutation Research Yajun Guo, PhD Director of Institute of Oncology, Second Military Medical University, Shanghai Yuan Xu, PhD VP, Process Development, Novartis Biologics, Switzerland Zhenping Zhu, MD, PhD Vice President, Novartis Biologics; Global Head, Protein Sciences and Design, Novartis, Switzerland Zhongchao Han, PhD Director of National Stem Cell Engineering Research Center, China Director of State Key Laboratory of Experimental Hematology Conference Secretariats: Yanyang Wang, Tel/Fax: 86-571-86971429 Susy Jin, Tel: 86-571-86971936 Liyun Fu Tel: 86-571-86971936 Wei Wang, Tel: 86-571-86971897 Address: 268, Kaixuan Road, Zhejiang University, Zhejiang California International NanoSystems Institute, Hangzhou, China, 310029 Email: westlakeconference@zcni.org Website: www.zcni.org/westlakeconference Attached is the registration process and receipt.