导师姓名 金叶 性别 女 职称 副研究员
专业名称 生物化学及生物工程 导师类别 □博导  硕导
所在单元 合成生物学工程研究中心 是否兼职  是 □否
招生专业
□物理化学（含化学物理）  生物化学与分子生物学□信号
与信息处理□模式识别与智能系统□计算机应用技术□材料
工程□电子与通信工程□控制工程□计算机技术  生物工程
合成生物器件及回路的创建、合成生物技术在肿瘤诊治上的应用、基因功能及
研究方向
在研课题
个人简历
调控等
1.
肿瘤细菌探杀器的研发
2.
小核糖核酸调节细菌致病因素的机制和意义
3.
核酸酶介导的多样化人工染色体
专长：微生物以及相关合成生物学研究，利用人造核酸开关对基因表达和表现
型进行灵活调控，并将其应用于肿瘤诊治等领域。
受教育经历：
2001/12 - 2015/03, 香港大学，哲学博士
1992/09 - 1999/07, 北京医科大学，硕士
研究工作经历：
2012/06 - 至今, 中国科学院深圳先进技术研究院，广州中国科学院先进
技术研究所，副研究员
2006/08 - 2012/05, 香港大学，李嘉诚医学院生物化学系，博士后
主要科研
成果及所
获荣誉
主要论著：
期刊论文：
1.
Jin Y , Huang JD. 2011. Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation. Nucleic Acids Research . doi:
10.1093/nar/gkr609.
2.
Mochon AB, Jin Y , Kayala MA, Wingard JR, Clancy CJ, Nguyen MH,
Felgner P, Baldi P, Liu H. 2010. Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia. PLoS Pathogen 6 : e1000827.
3.
Jin Y , Watt RM, Danchin A, Huang JD. 2009. Use of a riboswitch-controlled conditional hypomorphic mutation to uncover a role for the essential csrA gene in bacterial autoaggregation. Journal of
Biological Chemistry 284: 28738-28745.
4.
Jin Y, Watt RM, Danchin A, Huang JD. 2009. Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli. BMC Genomics
10: 165.

其他
联系方式
5.
Parahitiyawa NB, Samaranayake YH, Samaranayake LP, Jin Y , Tsang
PWK, Cheung BPK, Yau JYY and Yeung SKW. 2006. Interspecies variation in Candida biofilm formation studied using the Calgary biofilm device. APMIS 114: 298-306.
6.
Jin Y , Samaranayake YH, Yip HK, Samaranayake LP. 2005.
Characterization of switch phenotypes in Candida albicans Biofilms.
Mycopathologia 160: 191-200.
7.
Samaranayake YH, Jin Y , Yau JYY, Cheung BPK and Samaranayake
LP. 2005. In vitro method to study antifungal perfusion in Candida biofilms. Journal of Clinical Microbiology , 43: 818-825.
8.
Jin Y , Zhang T, Samaranayake YH, Fang HHP, Yip HK, Samaranayake LP.
2005. The use of new probes and stains for better assessment of cell viability and extracellular polymeric substances (EPS) in Candida albicans biofilms. Mycopathologia 159: 353-360.
9.
Jin Y* , Samaranayake LP, Samaranayake YH, Yip HK. 2004. Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars. Archives of Oral Biology 49: 789-798.
10.
Jin Y , Yip HK, Samaranayake YH, Yau JYY, Samaranayake LP. 2003.
Biofilm-forming ability of Candida albicans is unlikely to contribute to high levels of oral yeast carriage in cases of human immunodeficiency virus infection. Journal of Clinical Microbiology 41: 2961-2967.
11.
Jin Y, Yip HK. 2002. Supragingival calculus: formation and control.
Critical Reviews i  n Oral Biology & Medicine 13: 426-441.
专利： Two-way, portable riboswitch mediated gene expression control device.
Jan 1, 2013. 美国 . US2013/0004980A1.
邮箱 ye.jin@giat.ac.cn
电话
个人主页
18320093683
备注
Name Ye JIN Positions
Associate researcher
Academic title
PhD E-mail ye.jin@giat.ac.cn
Phone
Resume
Personal
18320093683
Website
Academic qualifications:
2005 Ph.D., Oral Biology Unit, the University of Hong Kong

1999 MDS,.
Beijing Medical University, China
1997 BDS., Beijing Medical University, China
Present academic position:
2012-present Associate researcher , Guangzhou Institute of Advanced
Technology, Chinese Academy of Science, P. R. China
Previous academic positions held:
2006-2012 Postdoctoral fellow, Department of Biochemistry, The University of Hong Kong, Hong Kong
2005-2006 Postdoctoral fellow , Department of Biological Chemistry,
University of California, Irvine, USA
Direction
1.
Regulatory mechanisms of small noncoding RNAs
2.
Engineering bacteria for specifically targeting and killing tumors
3.
Ribozyme-mediated diversification of synthetic genomes
1.
Engineering bacteria to specifically target tumors
2.
Engineering synthetic riboswitches for flexible control of gene expression and phenotypes
3.
Creation of portable two-way riboswitches
Achievements 4.
Demystification of regulatory mechanisms of small RNA, and rational design
Article and application of artificial small RNAs for user-defined purposes
Patent ： Two-way, portable riboswitch mediated gene expression control device.
Jan 1, 2013. US. US2013/0004980A1.
Publications:
1.
Jin Y , Huang JD. 2011. Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation. Nucleic Acids Research . doi:
10.1093/nar/gkr609.
2.
Mochon AB, Jin Y , Kayala MA, Wingard JR, Clancy CJ, Nguyen MH,
Felgner P, Baldi P, Liu H. 2010. Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia. PLoS Pathogen 6 : e1000827.
3.
Jin Y , Watt RM, Danchin A, Huang JD. 2009. Use of a riboswitch-controlled conditional hypomorphic mutation to uncover a role for the essential csrA gene in bacterial autoaggregation. Journal of
Biological Chemistry 284: 28738-28745.
4.
Jin Y, Watt RM, Danchin A, Huang JD. 2009. Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli. BMC Genomics
10: 165.
5.
Parahitiyawa NB, Samaranayake YH, Samaranayake LP, Jin Y , Tsang

PWK, Cheung BPK, Yau JYY and Yeung SKW. 2006. Interspecies variation in Candida biofilm formation studied using the Calgary biofilm device.
APMIS 114: 298-306.
6.
Jin Y , Samaranayake YH, Yip HK, Samaranayake LP. 2005.
Characterization of switch phenotypes in Candida albicans Biofilms.
Mycopathologia 160: 191-200.
7.
Samaranayake YH, Jin Y , Yau JYY, Cheung BPK and Samaranayake
LP. 2005. In vitro method to study antifungal perfusion in Candida biofilms.
Journal of Clinical Microbiology , 43: 818-825.
8.
Jin Y , Zhang T, Samaranayake YH, Fang HHP, Yip HK, Samaranayake LP.
2005. The use of new probes and stains for better assessment of cell viability and extracellular polymeric substances (EPS) in Candida albicans biofilms.
Mycopathologia 159: 353-360.
9.
Jin Y* , Samaranayake LP, Samaranayake YH, Yip HK. 2004. Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars. Archives of Oral Biology 49: 789-798.
10.
Jin Y , Yip HK, Samaranayake YH, Yau JYY, Samaranayake LP. 2003.
Biofilm-forming ability of Candida albicans is unlikely to contribute to high levels of oral yeast carriage in cases of human immunodeficiency virus infection. Journal of Clinical Microbiology 41: 2961-2967.
11.
Jin Y, Yip HK. 2002. Supragingival calculus: formation and control. Critical
Reviews in Oral Biology & Medicine 13: 426-441.