Conf. Dr. Ing Csaba Paizs
Criterii pentru Abilitare
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Referinţă bibliografică
si
ni
si/ ni
Paizs, Cs., Toşa, M. I., Majdik, C., Tähtinen, P., Irimie, F. D., Kanerva, L. T. (2003): Candida
Antarctica lipase A in the dynamic kinetic resolution of novel furylbenzothiazol–based
cyanohydrin acetates. Tetrahedron: Asymmetry 14, 619-627.
Paizs, Cs., Tähtinen, P., Lundell, K., Poppe, L., Irimie, F. D., Kanerva, L. T. (2003):
Preparation of novel phenylfuran-based cyanohydrin esters: lipase-catalysed kinetic and
dynamic resolution. Tetrahedron: Asymmetry 14, 1895-1904.
Paizs, Cs., Toşa, M. I., Bódai, V., Szakács, Gy., Kmecz, I., Simándi, B., Majdik, C., Novák,
L., Irimie F. D., Poppe L. (2003): Kinetic resolution of 1-(benzofuran-2-yl)ethanols by lipasecatalyzed enantiomer selective reactions. Tetrahedron: Asymmetry 14, 1943-1949.
Paizs, Cs., Tähtinen, P., Toşa, M. I., Majdik, C., Irimie, F. D., Kanerva, L. T. (2004)
Biocatalytic enantioselective preparation of phenothiazine-based cyanohydrin acetates: kinetic
and dynamic kinetic resolution. Tetrahedron 60, 10533-10540.
Paizs, Cs., Katona, A., Rétey, J. (2006) The Interaction of Heteroaryl-Acrylates and Alanines
with Phenylalanine Ammonia-Lyase from Parsley. Chemistry, a European Journal 12, 27392744.
Paizs, Cs., Katona, A., Rétey, J. (2006) Chemoenzymatic One-Pot Synthesis of Enantio-Pure LArylalanines From Arylaldehydes. European Journal of Organic Chemistry 1113-1116.
Katona, A., Toşa, M. I., Paizs, Cs., Rétey, J. (2006) Inhibition of Histidine Ammonia-Lyase by
Heteroaryl-alanines and Acrylates. Chemistry and Biodiversity 3, 502-508. (I.f. 1.616)
Paizs, Cs., Bartlewski-Hof, U., Rétey, J. (2007) Investigation of the Mechanism of Action of
Pyrogallol–Phloroglucinol Transhydroxylase by Using Putative Intermediates. Chemistry, a
European Journal 13, 2805-2811.
Paizs, Cs., Diemer, T., Rétey, J. (2008) The putative coenzyme B12-dependent methylmalonylCoA mutase from potatoes is a phosphatase. Bioorganic Chemistry 36, 261-264.
Podea, P., Toşa, M. I., Paizs, Cs., Irimie, F. D. (2008) Chemoenzymatic preparation of
enantiopure L-benzofuranyl- and L-benzo[b]thiophenyl alanines. Tetrahedron: Asymmetry 19,
500-511
Toşa, M. I., Pilbák, S., Moldovan, P., Paizs, Cs., Szatzker, G., Szakács, Gy., Novák, L., Irimie,
F. D., Poppe, L. (2008) Lipase-catalyzed kinetic resolution of racemic 1-heteroarylethanolsexperimental and QM/MM study. Tetrahedron: Asymmetry 19, 1844-1852.
Podea, P., Paizs, Cs., Toşa, M. I., Irimie, F. D. (2008) Baker’s yeast-mediated synthesis of (R)and (S)-heteroaryl-ethane-1,2-diols. Tetrahedron: Asymmetry 19, 1959-1964.
Toşa, M. I., Podea, P., Paizs, Cs., Irimie, F. D. (2008) Chemoenzymatic synthesis of (R)- and
(S)-1-heteroarylethanols. Tetrahedron: Asymmetry 19, 2068-2071.
Brem, J. Paizs, Cs., Toşa, M. I., Vass, E., Irimie, F. D. (2009) Enzyme-catalysed synthesis of
(R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives. Tetrahedron:
Asymmetry 20, 489-496.
Bencze L. Cs., Paizs, Cs., Toşa, M. I., Irimie, F. D. (2010) Substituent effects on the
stereochemical outcome of the baker’s yeast-mediated biotransformation of α-hydroxy- and αacetoxymethyl-5-phenylfuran-2-yl-ethanones. Tetrahedron: Asymmetry 21, 356-364.
Brem, J. Toşa, M. I., Paizs, Cs., Vass, E., Irimie, F. D. (2010) Enzyme-catalyzed synthesis of
(R)- and (S)-3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoic acids. Tetrahedron:
Asymmetry 21, 365-373.
Bencze L. Cs., Paizs, Cs., Toşa, M. I., Vass, E., Irimie, F. D. (2010) Synthesis of
enantiomerically enriched (R)- and (S)-benzofuranyl- and benzo[b]thiophenyl-1,2-ethanediols
1.36512
6
0.2275
1.36512
6
0.2275
1.36512
10
0.1365
1.53892
6
0.2564
4.80539
3
1.6017
1.64706
3
0.549
1.36228
4
0.340
4.80539
3
1.6017
1.00296
3
0.333
1.36512
4
0.334
1.36512
9
0.15168
1.36512
4
0.334
1.36512
4
0.334
1.36512
5
0.273
1.36512
4
0.334
1.36512
5
0.273
1.36512
5
0.273
via enantiopure cyanohydrins as intermediates. Tetrahedron: Asymmetry 21, 443-450.
Bencze L. Cs., Paizs, Cs., Toşa, M. I., Trif, M., Irimie, F. D. (2010) CaL-B a highly selective 1.36512
5
biocatalyst for the kinetic resolution of furylbenzthiazole-2-yl ethanols and acetates.
Tetrahedron: Asymmetry 21, 1999-2004.
19 Bencze, L. Cs., Paizs, Cs., Toşa, M. I., Irimie, F. D. Rétey, J. (2011) Chemoenzymatic One-Pot 1.66348
5
Synthesis of both (R)- and (S)-aryl-1,2-ethanediols. ChemCatChem 3, 343-346.
20
Bencze, L. Cs., Paizs, Cs., Toşa, M. I., Irimie, F. D. (2011) Sequential use of regio- and
1.36512
4
stereoselective lipases for the efficient kinetic resolution of racemic L-(5-phenylfuran-2yl)ethane-1,2-diols. Tetrahedron: Asymmetry 22, 675-683.
Total
 si/ ni
Ns
20
smed
18
0.273
0.332
0.334
8.51898
0.425
Îndeplinirea standardului Cmed
Nr. pub.
Care citează
Referinţa publicaţiei care citează
sk
Paizs, Cs., Toşa, M. I., Majdik, C., Tähtinen, P., Irimie, F. D., Kanerva, L. T. (2003): Candida Antarctica lipase A in the dynamic
kinetic resolution of novel furylbenzothiazol–based cyanohydrin acetates. Tetrahedron: Asymmetry 14, 619-627.
1
Gupta, M.N., Kapoor, M., Majumder, A.B., Singh, V. Isozymes, moonlighting proteins and promiscous
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enzymes (2011) Current Science, 100 (8), pp. 1152-1162.
Pace, V., Sinisterra, J.V., Alcántara, A.R. Celite-supported reagents in organic synthesis: An overview (2010)
Current Organic Chemistry, 14 (20), pp. 2384-2408.
Hietanen, A., Ekholm, F.S., Leino, R., Kanerva, L.T. Applying biocatalysis to the synthesis of diastereomerically
enriched cyanohydrin mannosides (2010) European Journal of Organic Chemistry, (36), pp. 6974-6980.
Turcu, M.C., Perkiö, P., Kanerva, L.T. Chemoenzymatic method to enantiopure Sulphur heterocyclic β-hydroxy
nitriles (2009) Arkivoc, 2009 (3), pp. 251-263.
Merabet-Khellasi, M., Aribi-Zouioueche, L., Riant, O. Chemoenzymatic synthesis of optically active 1,2disubstituted ferrocenes with planar chirality (2009) Tetrahedron Asymmetry, 20 (12), pp. 1371-1377.
Holt, J., Hanefeld, U. Enantioselective enzyme-catalysed synthesis of cyanohydrins (2009) Current Organic
Synthesis, 6 (1), pp. 15-37.
Zajac, M., Hrobárik, P., Magdolen, P., Foltínová, P., Zahradník, P.
Donor-π-acceptor
benzothiazole-derived dyes with an extended heteroaryl-containing conjugated system: synthesis, DFT study and
antimicrobial activity (2008) Tetrahedron, 64 (46), pp. 10605-10618
Pellissier, H. Recent developments in dynamic kinetic resolution (2008) Tetrahedron, 64 (8), pp. 1563-1601.
Belokon, Y.N., Blacker, A.J., Clutterbuck, L.A., Hogg, D., North, M., Reeve, C. An asymmetric, chemoenzymatic synthesis of O-acetylcyanohydrins (2006) European Journal of Organic Chemistry, (20), pp. 46094617.
Perrone, M.G., Santandrea, E., Giorgio, E., Bleve, L., Scilimati, A., Tortorella, P. A chemoenzymatic scalable
route to optically active (R)-1-(pyridin-3-yl)-2- aminoethanol, valuable moiety of β3-adrenergic receptor agonists
(2006) Bioorganic and Medicinal Chemistry, 14 (4), pp. 1207-1214.
Domínguez De María, P., Carboni-Oerlemans, C., Tuin, B., Bargeman, G., Van Der Meer, A., Van Gemert, R.
Biotechnological applications of Candida antarctica lipase A: State-of-the-art (2005) Journal of Molecular
Catalysis B: Enzymatic, 37 (1-6), pp. 36-46.
Veum, L., Hanefeld, U. Enantioselective synthesis of aliphatic cyanohydrin acetates (2005) Synlett, (15), pp.
2382-2384
Veum, L., Kanerva, L.T., Halling, P.J., Maschmeyer, T., Hanefeld, U. Optimisation of the enantioselective
synthesis of cyanohydrin esters (2005) Advanced Synthesis and Catalysis, 347 (7-8), pp. 1015-1021
Li, X.-G., Kanerva, L.T. Chemoenzymatic preparation of the enantiomers of β-tryptophan ethyl ester and the βamino nitrile analogue (2005) Tetrahedron Asymmetry, 16 (9), pp. 1709-1714.
Veum, L., Hanefeld, U. Enantioselective formation of mandelonitrile acetate: Investigation of a dynamic kinetic
resolution II (2004) Tetrahedron Asymmetry, 15 (23), pp. 3707-3709.
Pihko, A.J., Lundell, K., Kanerva, L., Koskinen, A.M.P. Enantioselective synthesis of a hindered furyl substituted
allyl alcohol intermediate: A case study in asymmetric synthesis (2004) Tetrahedron Asymmetry, 15 (10), pp.
2.13005
1.64706
0.55369
1.36512
2.05320
1.53892
1.53892
1.64706
1.80151
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1637-1643.
Purkarthofer, T., Skranc, W., Weber, H., Griengl, H., Wubbolts, M., Scholz, G., Pöchlauer, P. One-pot
chemoenzymatic synthesis of protected cyanohydrins (2004) Tetrahedron, 60 (3), pp. 735-739.
Gyarmati, Z.Cs., Liljeblad, A., Rintola, M., Bernáth, G., Kanerva, L.T. Lipase-catalyzed kinetic resolution of 7-,
8- and 12-membered alicyclic β-amino esters and N-hydroxymethyl-β-lactam enantiomers (2003) Tetrahedron
Asymmetry, 14 (23), pp. 3805-3814.
Hanefeld, U. Reagents for (ir)reversible enzymatic acylations (2003) Organic and Biomolecular Chemistry, 1
(14), pp. 2405-2415.
1.53892
1.36512
1.89754
Paizs, Cs., Tähtinen, P., Lundell, K., Poppe, L., Irimie, F. D., Kanerva, L. T. (2003): Preparation of novel phenylfuran-based
cyanohydrin esters: lipase-catalysed kinetic and dynamic resolution. Tetrahedron: Asymmetry 14, 1895-1904.
20
Pace, V., Sinisterra, J.V., Alcántara, A.R. Celite-supported reagents in organic synthesis: An overview (2010)
2.13005
Current Organic Chemistry, 14 (20), pp. 2384-2408.
21
Hietanen, A., Ekholm, F.S., Leino, R., Kanerva, L.T. Applying biocatalysis to the synthesis of diastereomerically
enriched cyanohydrin mannosides (2010) European Journal of Organic Chemistry, (36), pp. 6974-6980
1.64706
22
Li, Z., Tian, G., Ma, Y. One-Pot Three-Component Solvent-Free Cyanoaroylation of Aldehydes Using Potassium
Hexacyanoferrate(II) as an Environmentally Benign Cyanide Source (2010) Synlett, (14), art. No. W04410ST,
pp. 2164-2168
Xu, Q., Xie, Y., Geng, X., Chen, P. Enzymatic kinetic resolution of racemic cyanohydrins via enantioselective
acylation (2010) Tetrahedron, 66 (3), pp. 624-630.
Holt, J., Hanefeld, U. Enantioselective enzyme-catalysed synthesis of cyanohydrins (2009) Current Organic
Synthesis, 6 (1), pp. 15-37.
Kamaruddin, A.H., Uzir, M.H., Aboul-Enein, H.Y., Halim, H.N.A. Chemoenzymatic and microbial dynamic
kinetic resolutions (2009) Chirality, 21 (4), pp. 449-467
Pellissier, H. Recent developments in dynamic kinetic resolution (2008) Tetrahedron, 64 (8), pp. 1563-1601.
Purkarthofer, T., Skranc, W., Schuster, C., Griengl, H. Potential and capabilities of hydroxynitrile lyases as
biocatalysts in the chemical industry (2007) Applied Microbiology and Biotechnology, 76 (2), pp. 309-320.
1.27291
Belokon, Y.N., Blacker, A.J., Clutterbuck, L.A., Hogg, D., North, M., Reeve, C. An asymmetric, chemoenzymatic synthesis of O-acetylcyanohydrins (2006) European Journal of Organic Chemistry, (20), pp. 46094617.
Domínguez De María, P., Carboni-Oerlemans, C., Tuin, B., Bargeman, G., Van Der Meer, A., Van Gemert, R.
Biotechnological applications of Candida antarctica lipase A: State-of-the-art (2005) Journal of Molecular
Catalysis B: Enzymatic, 37 (1-6), pp. 36-46
Veum, L., Hanefeld, U. Enantioselective synthesis of aliphatic cyanohydrin acetates (2005) Synlett, (15), pp.
2382-2384
Veum, L., Kanerva, L.T., Halling, P.J., Maschmeyer, T., Hanefeld, U. Optimisation of the enantioselective
synthesis of cyanohydrin esters (2005) Advanced Synthesis and Catalysis, 347 (7-8), pp. 1015-1021.
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Paizs, Cs., Toşa, M. I., Bódai, V., Szakács, Gy., Kmecz, I., Simándi, B., Majdik, C., Novák, L., Irimie F. D., Poppe L. (2003):
Kinetic resolution of 1-(benzofuran-2-yl)ethanols by lipase-catalyzed enantiomer selective reactions. Tetrahedron: Asymmetry 14,
1943-1949.
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Bora, P.P., Bez, G., Anal, J.M.H. First example of hydrolytic kinetic resolution of acrylate of secondary alcohols
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by lipase Amano AK (2011) Journal of Molecular Catalysis B: Enzymatic, 72 (3-4), pp. 270-275
Agustian, J., Kamaruddin, A.H., Bhatia, S. Single enantiomeric β-blockers-The existing technologies (2010)
Process Biochemistry, 45 (10), pp. 1587-1604.
Ribeiro, A.S., Oliveira, M.V., Rebocho, S.F., Ferreira, O., Vidinha, P., Barreiros, S., MacEdo, E.A., Loureiro,
J.M. Enzymatic production of decyl acetate: Kinetic study in n –hexane and comparison with supercritical CO2
(2010) Industrial and Engineering Chemistry Research, 49 (16), pp. 7168-7175
Stepanenko, V., De Jesús, M., Correa, W., Bermúdez, L., Vázquez, C., Guzmán, I., Ortiz-Marciales, M. Chiral
spiroaminoborate ester as a highly enantioselective and efficient catalyst for the borane reduction of furyl,
thiophene, chroman, and thiochroman-containing ketones (2009) Tetrahedron Asymmetry, 20 (23), pp. 26592665.
Alatorre-Santamaria, S., Gotor-Fernandez, V., Gotor, V. Stereoselective chemoenzymatic synthesis of
enantiopure 1-(Heteroaryl)ethanamines by lipase-Catalysed kinetic resolutions (2009) European Journal of
Organic Chemistry, (15), pp. 2533-2538.
Varma, M.N., Madras, G. Effect of chain length on enzymatic hydrolysis of p-nitrophenyl esters in supercritical
carbon dioxide (2008) Applied Biochemistry and Biotechnology, 144 (3), pp. 213-223
Hobbs, H.R., Thomas, N.R. Biocatalysis in supercritical fluids, in fluorous solvents, and under solvent-free
conditions (2007) Chemical Reviews, 107 (6), pp. 2786-2820.
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Ghanem, A. Trends in lipase-catalyzed asymmetric access to enantiomerically pure/enriched compounds (2007)
Tetrahedron, 63 (8), pp. 1721-1754.
Santaniello, E., Casati, S., Ciuffreda, P. Lipase-catalyzed deacylation by alcoholysis: A selective, useful
transesterification reaction (2006) Current Organic Chemistry, 10 (10), pp. 1095-1123.
Matsuda, T., Harada, T., Nakamura, K., Ikariya, T. Asymmetric synthesis using hydrolytic enzymes in
supercritical carbon dioxide (2005) Tetrahedron Asymmetry, 16 (5), pp. 909-915
Matsuda, T., Harada, T., Nakamura, K. Biocatalysis in supercritical CO2 (2005) Current Organic Chemistry, 9
(3), pp. 299-315.
Ghanem, A., Aboul-Enein, H.Y. Application of lipases in kinetic resolution of racemates (2005) Chirality, 17
(1), pp. 1-15.
Ghanem, A., Aboul-Enein, H.Y. Lipase-mediated chiral resolution of racemates in organic solvents (2004)
Tetrahedron Asymmetry, 15 (21), pp. 3331-3351.
Hapau, D., Brem, J., Zaharia, V. Heterocycles 30: Lipase catalyzed kinetic resolution of racemic 1-(2-aryl-4methyl-thiazol-5-yl)ethanols (2011) Tetrahedron: Asymmetry, 22 (24), 2165-2171.
1.53892
2.13005
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2.13005
1.60553
1.36512
1.36512
Paizs, Cs., Tähtinen, P., Toşa, M. I., Majdik, C., Irimie, F. D., Kanerva, L. T. (2004) Biocatalytic enantioselective preparation of
phenothiazine-based cyanohydrin acetates: kinetic and dynamic kinetic resolution. Tetrahedron 60, 10533-10540.
46
Hietanen, A., Ekholm, F.S., Leino, R., Kanerva, L.T. Applying biocatalysis to the synthesis of diastereomerically
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enriched cyanohydrin mannosides (2010) European Journal of Organic Chemistry, (36), pp. 6974-6980
Pietruszka, J., Simon, R.C., Kruska, F., Braun, M. Dynamic enzymatic kinetic resolution of methyl 2,3-dihydro1h-indene-1- carboxylate (2009) European Journal of Organic Chemistry, (35), pp. 6217-6224.
Turcu, M.C., Perkiö, P., Kanerva, L.T. Chemoenzymatic method to enantiopure Sulphur heterocyclic β-hydroxy
nitriles (2009) Arkivoc, 2009 (3), pp. 251-263.
Holt, J., Hanefeld, U. Enantioselective enzyme-catalysed synthesis of cyanohydrins (2009) Current Organic
Synthesis, 6 (1), pp. 15-37.
Kamaruddin, A.H., Uzir, M.H., Aboul-Enein, H.Y., Halim, H.N.A. Chemoenzymatic and microbial dynamic
kinetic resolutions (2009) Chirality, 21 (4), pp. 449-467
Kamaruddin, A.H., Uzir, M.H., Aboul-Enein, H.Y., Halim, H.N.A. Chemoenzymatic and microbial dynamic
kinetic resolutions (2009) Chirality, 21 (4), pp. 449-467
Sakai, T., Wang, K., Ema, T. Lipase-catalyzed dynamic kinetic resolution gi
ving optically active cyanohydrins: use of silica-supported ammonium hydroxide and porous ceramic-immobilized
lipase (2008) Tetrahedron, 64 (9), pp. 2178-2183.
Pellissier, H. Recent developments in dynamic kinetic resolution (2008) Tetrahedron, 64 (8), pp. 1563-1601.
Gruber, C.C., Nestl, B.M., Gross, J., Hildebrandt, P., Bornscheuer, U.T., Faber, K., Kroutil, W. Emulation of
racemase activity by employing a pair of stereocomplementary biocatalysts (2007) Chemistry – A European
Journal, 13 (29), pp. 8271-8276.
Belokon, Y.N., Blacker, A.J., Clutterbuck, L.A., Hogg, D., North, M., Reeve, C. An asymmetric, chemoenzymatic synthesis of O-acetylcyanohydrins (2006) European Journal of Organic Chemistry, (20), pp. 46094617.
Veum, L., Pereira, S.R.M., Van Der Waal, J.C., Hanefeld, U. Catalytic hydrogenation of cyanohydrin esters as a
novel approach to N-acylated β-amino alcohols – Reaction optimisation by a design of experiment approach
(2006) European Journal of Organic Chemistry, (7), pp. 1664-1671.
Veum, L., Hanefeld, U. Carrier enabled catalytic reaction cascades (2006) Chemical Communications, (8), pp.
825-831.
Domínguez De María, P., Carboni-Oerlemans, C., Tuin, B., Bargeman, G., Van Der Meer, A., Van Gemert, R.
Biotechnological applications of Candida antarctica lipase A: State-of-the-art (2005) Journal of Molecular
Catalysis B: Enzymatic, 37 (1-6), pp. 36-46.
Veum, L., Hanefeld, U. Enantioselective synthesis of aliphatic cyanohydrin acetates (2005) Synlett, (15), pp.
2382-2384.
Sukumaran, J., Hanefeld, U. Enantioselective C-C bond synthesis catalysed by enzymes (2005) Chemical
Society Reviews, 34 (6), pp. 530-542
Veum, L., Kanerva, L.T., Halling, P.J., Maschmeyer, T., Hanefeld, U. Optimisation of the enantioselective
synthesis of cyanohydrin esters (2005) Advanced Synthesis and Catalysis, 347 (7-8), pp. 1015-1021.
Li, X.-G., Kanerva, L.T. Chemoenzymatic preparation of the enantiomers of β-tryptophan ethyl ester and the βamino nitrile analogue (2005) Tetrahedron Asymmetry, 16 (9), pp. 1709-1714.
1.64706
0.55369
2.05320
1.60553
1.60553
1.53892
1.53892
4.80539
1.64706
1.64706
4.75749
0.80764
1.27291
23.92216
4.33431
1.36512
Paizs, Cs., Katona, A., Rétey, J. (2006) The Interaction of Heteroaryl-Acrylates and Alanines with Phenylalanine Ammonia-Lyase
from Parsley. Chemistry, a European Journal 12, 2739-2744.
63
Gabriele, B., Mancuso, R., Lupinacci, E., Veltri, L., Salerno, G., Carfagna, C. Synthesis of benzothiophene
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derivatives by Pd-catalyzed or radical-promoted heterocyclodehydration of 1-(2-Mercaptophenyl)-2-yn-1-ols
(2011) Journal of Organic Chemistry, 76 (20), pp. 8277-8286
Cooke, H.A., Christianson, C.V., Bruner, S.D. Structure and chemistry of 4-methylideneimidazole-5-one
3.60968
containing enzymes (2009) Current Opinion in Chemical Biology, 13 (4), pp. 453-461.
65
Grogan, G. Biotransformations (2007) Physical Chemistry Chemical Physics, 9 (26), pp. 223-249
66
Watts, K.T., Mijts, B.N., Lee, P.C., Manning, A.J., Schmidt-Dannert, C. Discovery of a Substrate Selectivity
Switch in Tyrosine Ammonia-Lyase, a Member of the Aromatic Amino Acid Lyase Family (2006) Chemistry
and Biology, 13 (12), pp. 1317-1326.
2.60206
Paizs, Cs., Katona, A., Rétey, J. (2006) Chemoenzymatic One-Pot Synthesis of Enantio-Pure L-Arylalanines From Arylaldehydes.
European Journal of Organic Chemistry 1113-1116.
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Turner, N.J. Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids
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(2011) Current Opinion in Chemical Biology, 15 (2), pp. 234-240.
Kraußer, M., Winkler, T., Richter, N., Dommer, S., Fingerhut, A., Hummel, W., Gröger, H. Combination of C=C
bond formation by Wittig reaction and enzymatic C=C bond reduction in a one-pot process in water (2011)
ChemCatChem, 3 (2), pp. 293-296.
Kalaitzakis, D., Smonou, I. A two-step, one-pot enzymatic synthesis of 2-substituted 1,3-diols (2010) Journal of
Organic Chemistry, 75 (24), pp. 8658-8661.
Karmee, S.K., Roosen, C., Kohlmann, C., Lütz, S., Greiner, L., Leitner, W. Chemo-enzymatic cascade oxidation
in supercritical carbon dioxide/water biphasic media (2009) Green Chemistry, 11 (7), pp. 1052-1055.
Burda, E., Hummel, W., Gröger, H. Modular chemoenzymatic one-pot syntheses in aqueous media: Combination
of a palladium-catalyzed cross-coupling with an asymmetric biotransformation (2008) Angewandte Chemie –
International Edition, 47 (49), pp. 9551-9554.
Kraußer, M., Hummel, W., Gröger, H. Enantioselective one-pot two-step synthesis of hydrophobic allylic
alcohols in aqueous medium through the combination of a Wittig reaction and an enzymatic ketone reduction
(2007) European Journal of Organic Chemistry, (31), pp. 5175-5179.
De María, P.D., García-Burgos, C.A., Bargeman, G., Van Gemert, R.W. Pig liver esterase (PLE) as biocatalyst in
organic synthesis: From nature to cloning and to practical applications (2007) Synthesis, (10), pp. 1439-1452.
Watts, K.T., Mijts, B.N., Lee, P.C., Manning, A.J., Schmidt-Dannert, C. Discovery of a Substrate Selectivity
Switch in Tyrosine Ammonia-Lyase, a Member of the Aromatic Amino Acid Lyase Family (2006) Chemistry
and Biology, 13 (12), pp. 1317-1326.
1.66348
2.00985
4.40719
10.11377
1.64706
1.19606
2.60206
Katona, A., Toşa, M. I., Paizs, Cs., Rétey, J. (2006) Inhibition of Histidine Ammonia-Lyase by Heteroaryl-alanines and Acrylates.
Chemistry and Biodiversity 3, 502-508.
75
Murphy, J.T., Bruinsma, J.J., Schneider, D.L., Collier, S., Guthrie, J., Chinwalla, A., Robertson, J.D., Mardis,
6.26507
76
77
E.R., Kornfeld, K. Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans (2011) PloS
Genetics, 7 (3), art. No. E1002013, .
Cooke, H.A., Christianson, C.V., Bruner, S.D. Structure and chemistry of 4-methylideneimidazole-5-one
containing enzymes (2009) Current Opinion in Chemical Biology, 13 (4), pp. 453-461.
Martínez, C., Álvarez, R., Aurrecoechea, J.M. Palladium-catalyzed sequential oxidative cyclization/coupling of
2-alkynylphenols and alkenes: A direct entry into 3-alkenylbenzofurans (2009) Organic Letters, 11 (5), pp. 10831086.
3.60968
2.68768
Paizs, Cs., Bartlewski-Hof, U., Rétey, J. (2007) Investigation of the Mechanism of Action of Pyrogallol–Phloroglucinol
Transhydroxylase by Using Putative Intermediates. Chemistry, a European Journal 13, 2805-2811.
78
79
Dobbek, H. Structural aspects of mononuclear Mo/W-enzymes (2011) Coordination Chemistry Reviews, 255
(9-10), pp. 1104-1116.
Chantarasriwong, O., Cho, W.C., Batova, A., Chavasiri, W., Moore, C., Rheingold, A.L., Theodorakis, E.A.
Evaluation of the pharmacophoric motif of the caged Garcinia xanthones (2009) Organic and Biomolecular
Chemistry, 7 (23), pp. 4886-4894.
7.57674
1.89754
Podea, P., Toşa, M. I., Paizs, Cs., Irimie, F. D. (2008) Chemoenzymatic preparation of enantiopure L-benzofuranyl- and Lbenzo[b]thiophenyl alanines. Tetrahedron: Asymmetry 19, 500-511
80
Schevenels, F., Marko, I.E. Efficient and Connective Assembly of Highly Functionalized Benzofurans Using o2.68768
81
82
83
84
85
Hydroxyphenones and Dichloroethylene (2012) Organic Letters 14(5), 1298-1301.
Goswami, K., Paul, S., Bugde, S.T., Sinha, S. Synthesis of optically active homotryptophan and its oxygen and
sulfur analogues (2012) Tetrahedron 68(1), 280-286.
Pellissier, H. Recent developments in dynamic kinetic resolution (2011) Tetrahedron, 67 (21), pp. 3769-3802.
Staples, M.K., Grange, R.L., Angus, J.A., Ziogas, J., Tan, N.P.H., Taylor, M.K., Schiesser, C.H. Tandem freeradical addition/substitution chemistry and its application to the preparation of novel AT1 receptor antagonists
(2011) Organic and Biomolecular Chemistry, 9 (2), pp. 473-479.
Busto, E., Gotor-Fernández, V., Gotor, V. Hydrolases: Catalytically promiscuous enzymes for non-conventional
reactions in organic synthesis (2010) Chemical Society Reviews, 39 (11), pp. 4504-4523.
Sinkeldam, R.W., Greco, N.J., Tor, Y. Fluorescent analogs of biomolecular building blocks: Design, properties,
and applications (2010) Chemical Reviews, 110 (5), pp. 2579-2619.
1.53892
1.53892
1.89754
23.92216
37.36527
86
87
88
89
Turner, N.J. Deracemisation methods (2010) Current Opinion in Chemical Biology, 14 (2), pp. 115-121.
Gotor-Fernández, V., Gotor, V. Biocatalytic routes to chiral amines and amino acids (2009) Current Opinion in
Drug Discovery and Development, 12 (6), pp. 784-797.
Sarkar, K., Singha, S.K., Chattopadhyay, S.K. A new and
general route to 2-pyrrolylglycine, 2-pyrrolylalanine and homo-2-pyrrolylalanine derivatives (2009) Tetrahedron
Asymmetry, 20 (15), pp. 1719-1721.
Šafář, P., Žúžiová, J., Marchalín, S., Tóthová, E., Prónayová, N., Švorc, L., Vrábel, V., Daïch, A. Highly
diastereoselective approach to novel phenylindolizidinols via benzothieno analogues of tylophorine based on
reductive desulfurization of benzo[b]thiophene (2009) Tetrahedron Asymmetry, 20 (5), pp. 626-634.
3.60968
1.73429
1.36512
1.36512
Toşa, M. I., Pilbák, S., Moldovan, P., Paizs, Cs., Szatzker, G., Szakács, Gy., Novák, L., Irimie, F. D., Poppe, L. (2008) Lipasecatalyzed kinetic resolution of racemic 1-heteroarylethanols-experimental and QM/MM study. Tetrahedron: Asymmetry 19, 18441852.
90
Shiina, I., Ono, K., Nakata, K. Kinetic resolution of racemic 1-heteroarylalkanols by asymmetric esterification
1.18263
91
92
93
94
95
using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst (2011) Chemistry Letters, 40
(2), pp. 147-149.
Xu, T., Zhang, L., Su, E., Cui, D., Wang, X., Wei, D. Disparity in productive binding mode of the slow-reacting
enantiomer determines the novel catalytic behavior of Candida antarctica lipase B (2010) Journal of Molecular
Catalysis B: Enzymatic, 62 (3-4), pp. 288-296.
Stepanenko, V., De Jesús, M., Correa, W., Bermúdez, L., Vázquez, C., Guzmán, I., Ortiz-Marciales, M. Chiral
spiroaminoborate ester as a highly enantioselective and efficient catalyst for the borane reduction of furyl,
thiophene, chroman, and thiochroman-containing ketones (2009) Tetrahedron Asymmetry, 20 (23), pp. 26592665.
Pilissão, C., Carvalho, P.d.O., Nascimento, M.d.G. Enantioselective acylation of (RS)-phenylethylamine
catalysed by lipases (2009) Process Biochemistry, 44 (12), pp. 1352-1357.
Machado, L.L., de Gonzalo, G., Lemos, T.L.G., de Mattos, M.C., de Oliveira, M.d.C.F., Gotor-Fernández, V.,
Gotor, V. Enantioselective acetylation of racemic alcohols by Manihot esculenta and Passiflora edulis
preparations (2009) Journal of Molecular Catalysis B: Enzymatic, 60 (3-4), pp. 157-162.
Hapau, D., Brem, J., Zaharia, V. Heterocycles 30: Lipase catalyzed kinetic resolution of racemic 1-(2-aryl-4methyl-thiazol-5-yl)ethanols (2011) Tetrahedron: Asymmetry, 22 (24), 2165-2171.
0.80764
1.36512
2.26730
0.80764
1.36512
Toşa, M. I., Podea, P., Paizs, Cs., Irimie, F. D. (2008) Chemoenzymatic synthesis of (R)- and (S)-1-heteroarylethanols.
Tetrahedron: Asymmetry 19, 2068-2071.
96
García-Urdiales, E., Alfonso, I., Gotor, V. Update 1 of: Enantioselective enzymatic desymmetrizations in organic 37.36527
97
98
99
synthesis (2011) Chemical Reviews, 111 (5), pp. PR110-PR180.
Stepanenko, V., De Jesús, M., Correa, W., Bermúdez, L., Vázquez, C., Guzmán, I., Ortiz-Marciales, M. Chiral
spiroaminoborate ester as a highly enantioselective and efficient catalyst for the borane reduction of furyl,
thiophene, chroman, and thiochroman-containing ketones (2009) Tetrahedron Asymmetry, 20 (23), 2659-2665.
Alatorre-Santamaria, S., Gotor-Fernandez, V., Gotor, V. Stereoselective chemoenzymatic synthesis of
enantiopure 1-(Heteroaryl)ethanamines by lipase-Catalysed kinetic resolutions (2009) European Journal of
Organic Chemistry, (15), pp. 2533-2538.
Hapau, D., Brem, J., Zaharia, V. Heterocycles 30: Lipase catalyzed kinetic resolution of racemic 1-(2-aryl-4methyl-thiazol-5-yl)ethanols (2011) Tetrahedron: Asymmetry, 22 (24), 2165-2171.
1.36512
1.64706
1.36512
Podea, P., Paizs, Cs., Toşa, M. I., Irimie, F. D. (2008) Baker’s yeast-mediated synthesis of (R)- and (S)-heteroaryl-ethane-1,2-diols.
Tetrahedron: Asymmetry 19, 1959-1964.
100
Silva, V.D., Stambuk, B.U., Nascimento M.D Asymmetric reduction of (4R)-(-)-carvone catalyzed by Baker's
0.80764
101
102
103
yeast in aqueous mono- and biphasic systems. (2012) Journal of Molecular Catalysis B-Enzymatic 77, 98-104
Huang, K., Wang, H., Stepanenko, V., De Jesús, M., Torruellas, C., Correa, W., Ortiz-Marciales, M. Chiral
epoxides via borane reduction of 2-haloketones catalyzed by spiroborate ester: Application to the synthesis of
optically pure 1,2-hydroxy ethers and 1,2-azido alcohols (2011) Journal of Organic Chemistry, 76 (6), pp. 18831886.
Zeror, S., Collin, J., Fiaud, J.-C., Zouioueche, L.A. Enantioselective ketoester reductions in water: A comparison
between microorganism-and ruthenium-catalyzed reactions (2010) Tetrahedron Asymmetry, 21 (9-10), pp. 12111215.
Kwak, S.H., Lee, D.-M., Lee, K.-I. Enantioselective Rh-catalyzed transfer hydrogenation of α-sulfonyloxy
heteroaryl ketones; asymmetric synthesis of (S)-bufuralol (2009) Tetrahedron Asymmetry, 20 (22), 2639-2645.
2.00985
1.36512
1.36512
Brem, J. Paizs, Cs., Toşa, M. I., Vass, E., Irimie, F. D. (2009) Enzyme-catalysed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxypropanoic acids and their derivatives. Tetrahedron: Asymmetry 20, 489-496.
104
Aburano, D., Inagaki, F., Tomonaga, S., Mukai, C. Synthesis of a core carbon framework of cyanosporasides A
2.00985
and B (2009) Journal of Organic Chemistry, 74 (15), pp. 5590-5594.
Bencze L. Cs., Paizs, Cs., Toşa, M. I., Vass, E., Irimie, F. D. (2010) Synthesis of enantiomerically enriched (R)- and (S)-
benzofuranyl- and benzo[b]thiophenyl-1,2-ethanediols via enantiopure cyanohydrins as intermediates. Tetrahedron: Asymmetry 21,
443-450.
105
He, Y., Wang, B., Dukor, R.K., Nafie, L.A. Determination of absolute configuration of chiral molecules using
1.20869
vibrational optical activity: A review (2011) Applied Spectroscopy, 65 (7), pp. 699-723.
Bencze, L. Cs., Paizs, Cs., Toşa, M. I., Irimie, F. D. Rétey, J. (2011) Chemoenzymatic One-Pot Synthesis of both (R)- and (S)aryl-1,2-ethanediols. ChemCatChem 3, 343-346.
106
Hollmann, F., Arends, I.W.C.E., Holtmann, D. Enzymatic reductions for the chemist (2011) Green Chemistry,
4.40719
13 (9), pp. 2285-2313.
107
Shanmuganathan, S., Natalia, D., Greiner, L., de Maria, P.D. Oxidation-hydroxymethylation-reduction: a one-pot
three-step biocatalytic synthesis of optically active alpha-aryl vicinal diols (2012) Green Chemistry 14 (1), 94-97
Nc
107
Cmed
4.40719
5.35
Îndeplinirea standardului P
Nr.
Pub.
1
Referinţă bibliografică
si
pi
si/ pi
Paizs, Cs., Toşa, M. I., Majdik, C., Bodai, V., Novák, L., Irimie, F. D., Poppe, L. (2002):
Chemo-enzymatic preparation of hydroxymethyl ketones. Journal of the Chemical
1.89754
1
1.89754
1.36512
1
1.36512
1.36512
1
1.36512
1.36512
1
1.36512
1.53892
1
1.53892
4.80539
1
4.80539
1.64706
1
1.64706
4.80539
1
4.80539
1.00296
1
1.00296
1.36512
1
1.36512
a
2
3
4
5
6
7
8
9
10
Society, Perkin Transactions 1 21, 2000-2002.
Paizs, Cs., Toşa, M. I., Majdik, C., Tähtinen, P., Irimie, F. D., Kanerva, L. T. (2003):
Candida Antarctica lipase A in the dynamic kinetic resolution of novel
furylbenzothiazol–based cyanohydrin acetates. Tetrahedron: Asymmetry 14, 619-627.
Paizs, Cs., Tähtinen, P., Lundell, K., Poppe, L., Irimie, F. D., Kanerva, L. T. (2003):
Preparation of novel phenylfuran-based cyanohydrin esters: lipase-catalysed kinetic and
dynamic resolution. Tetrahedron: Asymmetry 14, 1895-1904.
Paizs, Cs., Toşa, M. I., Bódai, V., Szakács, Gy., Kmecz, I., Simándi, B., Majdik, C.,
Novák, L., Irimie F. D., Poppe L. (2003): Kinetic resolution of 1-(benzofuran-2yl)ethanols by lipase-catalyzed enantiomer selective reactions. Tetrahedron: Asymmetry
14, 1943-1949.
Paizs, Cs., Tähtinen, P., Toşa, M. I., Majdik, C., Irimie, F. D., Kanerva, L. T. (2004)
Biocatalytic enantioselective preparation of phenothiazine-based cyanohydrin acetates:
kinetic and dynamic kinetic resolution. Tetrahedron 60, 10533-10540.
Paizs, Cs., Katona, A., Rétey, J. (2006) The Interaction of Heteroaryl-Acrylates and
Alanines with Phenylalanine Ammonia-Lyase from Parsley. Chemistry, a European
Journal 12, 2739-2744.
Paizs, Cs., Katona, A., Rétey, J. (2006) Chemoenzymatic One-Pot Synthesis of EnantioPure L-Arylalanines From Arylaldehydes. European Journal of Organic Chem. 1113-1116.
Paizs, Cs., Bartlewski-Hof, U., Rétey, J. (2007) Investigation of the Mechanism of Action
of Pyrogallol–Phloroglucinol Transhydroxylase by Using Putative Intermediates.
Chemistry, a European Journal 13, 2805-2811.
Paizs, Cs., Diemer, T., Rétey, J. (2008) The putative coenzyme B12-dependent
methylmalonyl-CoA mutase from potatoes is a phosphatase. Bioorganic Chemistry 36,
261-264.
Brem, J., Naghi, M. Tosa, M.I., Boros, Z., Poppe, L., Irimie, F.D., Paizs, Cs. (2011)
Lipase mediated sequential resolution of aromatic beta-hydroxy esters using fatty acid
derivatives. Tetrahedron:Asymmetry 22, 1672-1679.
Total:
P= 21.15
Criteriile Smed=0.42, Cmed=5.35, P=21.15 pentru abilitare sunt îndeplinite.
Conf. Dr. Ing. Csaba Paizs
Cluj-Napoca
22.05.2012
a
Transformed into Organic and Biomolecular Chemistry