1260, either, cat: 26
THREE POLYMORPHISMS OF THE HUMAN RESISTIN GENE ARE MAJOR
DETERMINANTS OF PLASMA LEVEL OF RESISTIN IN JAPANESE
H. Asano2, H. Izawa2, M. Kobayashi2, A. Hirashiki2, Y. Murase2, D. Tanimura2,
T. Yamada2, K. Unno2, T. Murohara2, M. Yokota1
1
Theranostic Research Institute Inc, Nagoya, Japan, 2Nagoya University Graduate School
of Medicine, Nagoya, Japan, 3Aichi Gakuin University, Nagoya, Japan
Background: Resistin is a cytokine derived from adipose tissue and is implicated in the
pathogenesis of obesity-related insulin resistance. We investigated the relations between
plasma resistin concentration and twelve polymorphisms of the resistin gene, obesity, and
other metabolic parameters in a Japanese cohort.
Subjects and Methods: The study population comprised 3231 Japanese subjects ( 1,426
men and 1,805 women ) who underwent community-based annual health check in
Kitanagoya city, Japan ( KING study ) between May 2005 and December 2007. Plasma
resistin concentration, body mass index, blood pressure, fasting plasma glucose
concentration, fasting serum insulin concentration, hemoglobin (Hb) A1c content, lipid
profile, and uric acid concentration were measured. The homeostasis model assessment
of insulin resistance (HOMA-IR) was also calculated. Twelve polymorphisms of the
resistin gene were genotyped.
Results: The plasma resistin level was significantly higher in subjects with the six-repeat
allele of the ATG repeat polymorphism, in those with the –638A allele and in those with
the +62G allele than in the corresponding individuals without these alleles (P < 0.001 in
each case). Furthermore, the plasma resistin level was also significantly correlated with
serum uric acid concentration, serum HDL-cholesterol concentration, serum triglyceride
concentration and serum insulin concentration.
Conclusions: These three polymorphisms of the resistin gene were robust and
independent determinants of serum resistin concentration. However, the serum resistin
level was also correlated with uric acid concentration, HDL-cholesterol level, triglyceride
level and serum insulin concentration. These results may imply that the plasma
concentration of resistin contributes the development of atherosclerotic disorders.