Alzheimer’s Disease Research Quality Phenotype Does anyone in the group other than Group
Health have this quality information? The first target phenotype that we will analyze in the
ADPR/ACT population is probable or possible AD based on NINCDS-ADRDA criteria.
A 2-stage screening process is used to identify cases; CASI scores ≤85 prompt a dementia evaluation (in HAAS the CASI cut point is 74). Informant, subject, or staff reports of cognitive difficulties also trigger evaluation. The 2nd stage diagnostic examination has two parts: neuropsychological testing and a neurological exam by a physician. Medical records are abstracted for standardized labs (CBC, chemistry panel, B12, TSH) and neuroimaging. If any of these are unavailable in the prior year they are obtained. These data are used to complete standard DSM-IV diagnostic criteria for dementia and subtypes, NINCDS-ADRDA criteria for
AD, and 3 sets of criteria for vascular dementia. The dementia neuropsychological battery includes clock drawing, verbal fluency, Mattis Dementia Rating Scale, Boston naming, verbal paired associations and recall, logical memory and recall, Word List Memory, Constructional
Praxis and recall, Trails A and B, and Information and Comprehension subtest items. All clinical data are reviewed at a consensus conference. These procedures have been used continuously over
22 years since the inception of the ADPR in 1986. ACT dementia and AD diagnoses have been used in many papers, including an incidence rate paper, and high-impact papers on exercise, cholesterol, statins, and vitamins.
Of note, in the first 221 ACT subjects who died and came to post-mortem examination, clinical diagnoses during life of probable AD and possible AD were equally likely to be found to have high-grade plaques and tangles: for probable AD, 18/33 (55%) had both Braak stage >=4
AND CERAD score >=2, while for possible AD these numbers were 10/19 (53%). The distribution of Braak stages was similar for the two groups.
Case = Probable/possible Alzheimer’s disease adjudicated by a consensus panel
Each case reviewed by a consensus panel that includes:

The examining MD

A second MD who is either a neurologist or geriatrician

A neuropsychologist

A psychometrician

The study RN
Criteria Used by panel:
1.
Meets DSM IV – Dementia criteria
2.
NINCDS-ADRDA criteria for probable and possible Alzheimer’s.
3.
Study also has an autopsy “bank” (relevant for diagnosis of definite Alzheimer’s) and approximately 1,200 consents for autopsy from currently living participants.
Dementia Clinical Quality Phenotype
Identify Dementialusing an ICD-9 DX codes ora drug from the following list: Tacrine (Cognex), donepezil (Aricept, Eisai Inc. and Pfizer Inc.), galantamine (Razadyne, also called Reminyl prior

to April 2005, Ortho-McNeil Neurologics, US), rivastigmine (Exelon, ExelonPatch, Novartis
Pharmaceuticals Corporation), memantine (Namenda)."
The VDW program we propose is: title "Identify people with Demential including Alzheimber's Disease using clinical DX and Drugs";
%let StartDt = 01jan2000 ;
%let EndDt = 31dec2007 ;
* Get those with Alzheimer's DX code;
************************************; data DxCodes ;
input Dx $char6. ; cards;
290.0
290.10
290.11
Senile dementia, uncomplicated
290-10-290.13 Presenile dementia
290.12
290.13
290.20
290.21
290.3 senile dementia delusionial [paranoid] features senile dementia with depressive features
290.40
290.41
290.42 senile dementia with delirium or confusion
290.40-290.43 arteriosclerotic dementia
Vascular dementia with delirium
Vascular dementia with delusions
290.43
291.0
291.1
291.0-291.2 dementia due to alcohol
291.2
292.82
294.10 arteriosclerotic dementia due to drugs
294.10-294.11 dementia not classified as senile, presenile, or
294.11
331.0
331.11
331.19
331.82
Alzheimer's disease
Pick's disease of the brain
Other frontotemporal dementia
Dementia with Lewy bodies. Dementia with Parkinsonism run;
* comment for 5 digit codes do we need to expand to 6? i.e. 291.0x? ;
%GetDxForDx(
DxCodes /* The name of a dataset containing the diagnosis
list you want. */
, Dx /* The name of the DX variable in DxLst */
, &StartDt /* The date on which you want to start collecting fills. */

, &EndDt /* The date on which you want to stop collecting fills. */
, AlzDxPeople /* The name of the output dataset containing the fills. */
) ; run;
* Get Alzheimer's drugs from RX;
**************************; data NdcCodes;
input ndc $char11. ; cards;
000071009625 NDC for "Tacrine 10 MG Oral Capsule":
000071009640
00071009625
00071009640
00143910812
059630019012
59630019012
000071009725
000071009740
00071009725
00071009740
00143910912
059630019112
59630019112
000071009525
000071009540
00071009525
00071009540
00143911012
059630019212
59630019212
000071009825
000071009840
00071009825
00071009840
00143911112
059630019312
59630019312
000143-9108-12
00071009625
00071009625
00071009640
00071009640
00143910812
059630-*190-12
59630-190-12
NDC for "Tacrine 20 MG Oral Capsule":
NDC for "Tacrine 30 MG Oral Capsule":
NDC for "Tacrine 40 MG Oral Capsule":
NDC for "Cognex 10 MG Oral Capsule":

59630019012
59630019012
62856085130
062856083230
49999075430
62856083230
00247181930
00247181960
00615552305
00615552331
00615552339
011071-*832-01
011071-*842-01
062856024630
062856024641
11071083201
11071084201
12280036715
12280036730
12280036790
26053012201
51129412601
51129412602
54868424500
55289015121
55289015130
58864089530
62856024611
62856024617
62856024630
62856024641
62856024690
66105073701
66105073703
66105073706
66105073709
66105073715
67544009215
67544009231
67544009288
67544009289
011071-*831-01
062856083130
11071083101
49999075330
62856083130
NDC for "donepezil 1 MG/ML Oral Solution":
NDC for "donepezil 10 MG Disintegrating Tablet":
NDC for "donepezil 10 MG Oral Tablet":
NDC for "donepezil 5 MG Disintegrating Tablet":

00247181830
00615552905
00615552931
00615552939
011071-*841-01
062856024530
062856024541
11071084101
12280029215
12280029230
12280029290
26053012101
54868395200
55154245000
58864088630
62584017750
62856024507
62856024511
62856024530
62856024541
62856024547
62856024567
62856024590
66105073901
66105073903
66105073906
66105073909
66105073915
67544059231
00615652631
00615652639
050458039260
050458039860
21695059130
50458039260
50458039860
59604039260
59604039860
62579039260
050458038830
50458038804
50458038830
59604038804
59604038830
050458038930
50458038930
NDC for "donepezil 5 MG Oral Tablet":
NDC for "Galantamine 12 MG Oral Tablet":
NDC for "Galantamine 16 MG Extended Release Capsule":
NDC for "Galantamine 24 MG Extended Release Capsule":

59604038930
000179-1721-70
000179-1721-71
000179-1721-72
00179172170
00179172171
00179172172
00615652531
00615652539
050458039060
050458039660
12280029160
21695018430
26053015501
50458039004
50458039060
50458039660
51129332501
51129332502
59604039060
59604039660
61392055925
61392055930
61392055960
62579039040
62579039060
050458039910
12578039910
12578049010
50458039910
50458049010
050458038730
50458038704
50458038730
59604038704
59604038730
00615651731
00615651739
050458039160
050458039760
26053015601
50458039104
50458039160
50458039760
51129332901
51129332902
NDC for "Galantamine 4 MG Oral Tablet":
NDC for "Galantamine 4 MG/ML Oral Solution":
NDC for "Galantamine 8 MG Extended Release Capsule":
NDC for "Galantamine 8 MG Oral Tablet":

59604039104
59604039160
59604039765
62579039160
000078050115
Patch":
00078050115
00078050161
17088010401
59568050101
000078050215
Patch":
00078050215
00078050261
0078-0502-15
17088010501
59568050201
000078032306
000078032308
000078032344
00078032306
00078032308
00078032315
00078032326
00078032344
055111-*352-01
055111-*352-05
055111-*352-30
055111-*352-60
12280038960
17088001801
26053029901
54868451200
54868451201
55111035201
55111035205
55111035230
55111035260
66544000401
66828001201
000078033931
00078033931
000078032406
000078032408
000078032444
00078032406
NDC for "24 HR rivastigmine 0.192 MG/HR Transdermal
NDC for "24 HR rivastigmine 0.396 MG/HR Transdermal
NDC for "rivastigmine 1.5 MG Oral Capsule":
NDC for "rivastigmine 2 MG/ML Oral Solution":
NDC for "rivastigmine 3 MG Oral Capsule":

00078032408
00078032415
00078032444
00615136531
00615136539
055111-*353-01
055111-*353-05
055111-*353-30
055111-*353-60
17088001901
17856032402
26053030001
55111035301
55111035305
55111035330
55111035360
66544000201
66828001301
000078032506
000078032508
000078032544
00078032506
00078032508
00078032515
00078032544
00615136931
00615136939
055111-*354-01
055111-*354-05
055111-*354-30
055111-*354-60
17088002001
54868524000
55111035401
55111035405
55111035430
55111035460
66828001401
000078032506
000078032508
000078032544
00078032506
00078032508
00078032515
00078032544
00615136931
NDC for "rivastigmine 4.5 MG Oral Capsule":
NDC for "rivastigmine 4.5 MG Oral Capsule":

00615136939
055111-*354-01
055111-*354-05
055111-*354-30
055111-*354-60
17088002001
54868524000
55111035401
55111035405
55111035430
55111035460
66828001401
000078032506
000078032508
000078032544
00078032506
00078032508
00078032515
00078032544
00615136931
00615136939
055111-*354-01
055111-*354-05
055111-*354-30
055111-*354-60
17088002001
54868524000
55111035401
55111035405
55111035430
55111035460
66828001401
000456321021
000456321022
000456321060
000456321063
00247212130
00247212160
00456321010
00456321011
00456321021
00456321022
00456321060
00456321063
00615650805
00615650831
NDC for "rivastigmine 4.5 MG Oral Capsule":
NDC for "Memantine 10 MG Oral Tablet":

00615650839
12280028430
12280028460
21695016930
21695016960
26053021501
49999080430
49999080460
51129284901
51129284902
55154461508
55154461800
55289093730
55289093760
58864088730
63711041010
67544050531
67544050532
63711041510
000456320212
00456320212
63711042010
000456320521
000456320522
000456320560
000456320563
00456320511
00456320521
00456320522
00456320560
00456320563
00615651931
00615651939
12280038160
21695023260
26053021601
54868565400
55154461700
63629338301
63629338302
63629338303
63629338304
63711040510
67544062631 run;
NDC for "Memantine 15 MG Oral Tablet":
NDC for "Memantine 2 MG/ML Oral Solution":
NDC for "Memantine 20 MG Oral Tablet":
NDC for "Memantine 5 MG Oral Tablet":

%GetRxForDrugs(
NdcCodest
, &StartDt
, &EndDt
/* The name of a dataset containing the NDCs of the drugs whose fills you want. */
/* The date on which you want to start collecting fills.*/
/* The date on which you want to stop collecting fills. */
, AlzRxPeople /* The name of the output dataset containing the fills. */
) ;