BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Hsian-Rong Tseng
Associate Professor
eRA COMMONS USER NAME
TSENG2
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Tunghai University, Taiwan
National Taiwan University, Taiwan
University of California, Los Angeles
DEGREE
(if applicable)
YEAR(s)
B.S.
Ph.D.
Postdoc
1989-1993
1993-1998
2000-2003
FIELD OF STUDY
Chemistry
Organic Chemistry
Supramolecular and
Physical Chemistry
A. Positions and Honors
Professional Experience
1993-1998
Graduate Research Fellow, Department of Chemistry, National Taiwan University,
Research Advisor: Dr. Tien-Yau Luh
1998-2000
Second lieutenant, Combined Service Force, Department of Defense, Taiwan
2000-2003
Postdoctoral Fellow, Department of Chemistry and Biochemistry, UCLA
Research Advisor: Dr. J. Fraser Stoddart
2003-2009
Assistant Professor, Department of Molecular and Medical Pharmacology, UCLA
2009-present
Associate Professor, Department of Molecular and Medical Pharmacology, UCLA
Honors
2003
2004
2004
2005
Chancellor’s Award for Postdoctoral Research, UCLA
Speaker in the National Academy of Science Symposium for Frontiers in Science
Seed Grant - Faculty Development Award, David Geffen School of Medicine at UCLA
Arthur K. Doolittle Award, PMSE Division, American Chemical Society
Professional and Society Committee Service
2000
American Chemical Society
2003
Material Research Society
2004
Academy of Molecular Imaging
B. Publications (2004-2009, selected from 62 peer-reviewed publications)
1.
Marchioni, F.; Venturi, M.; Credi, A.; Balzani, V.; Behloradsky, M.; Elizarov, A. M.; Tseng, H.-R.; Stoddart J.
F. “Polyvalent Scaffold. Counting the Number of Seats Available for Eosin Guest Molecules in
Viologen-Based host Dendrimers.” J. Am. Chem. Soc. 2004, 126, 568-573.
2.
Hernandez, R.; Tseng, H.-R.; Wong, J. W.; Stoddart, J. F.; Zink, J. I. “An Operational Supramolecular
Nanovalve.” J. Am. Chem. Soc. 2004, 126, 3370-3371.
3.
Wang, J.; Chen, S.; Carlson, R. R.; Luo, Y.; Ge, G.; Ries, R. S.; Heath, J. R.; Tseng, H.-R.
“Electrochemically Fabricated Conducting Polymer Nanoframework-Electrode Junctions for Electronic
Sensing.” Nano Lett. 2004, 4, 1693-1697.
4.
Huang, T. J.; Tseng, H.-R.; Sha, L.; Lu, W.; Brough, B.; Flood, A. H.; Yu, B.-D.; Celestre, P. C.; Chang, P.
J.; Stoddart, J. F.; Ho, C.-M. “Mechanical Shuttling of Linear Motor-Molecules in Condensed Phases on
Solid Substrates.” Nano Lett. 2004, 4, 2065-2071.
5.
Steuerman, D. W.; Tseng, H.-R.; Peters, A. J.; Flood, A. H.; Jeppesen, J. O.; Nielsen, K. A.; Stoddart, J. F.;
Heath, J. R. “The Dynamics of Molecular Mechanical Switches within Solid-State Polymer Electrolytes.”
Angew. Chem. Int. Ed. 2004, 43, 6486-6491.
6.
Nørgaard, K.; Laursen, B. W.; Nygaard, S.; Kjaer, K.; Tseng, H.-R.; Flood, A.H.; Stoddart, J. F.; Bjørnholm
T. “Structural Evidence of Mechanical Shuttling in Condensed Monolayers of Rotaxane Molecules.”
Angew. Chem., Int. Ed. 2005, 43, 7035-7039. Nguyen, T. D.; Tseng, H.-R.; Celestre, P. C.; Flood, A. H.;
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Liu, Y.; Stoddart, J. F.; Zink, J. I. “A Reversible Molecular Valve.” Proc. Natl. Acad. Sci. USA. 2005, 102,
10029-10034.
Lee, C.-C.; Sui, G.; Elizarov, A.; Shu, C. J.; Shin, Y.-S.; Doole, A. N.; Huang, J.; Darion, A.; Wyatt P.; Stout,
D.; Kolb, H. C.; Witte, O. N.; Satyamurthy, N.; Heath, J. R.; Phelps, M. E.; Quake, S. R.; Tseng H.-R.
“Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics.” Science 2005, 310,
1793-1796.
Wang, J.; Bunimovich, Y. L.; Sui, G.; Savvas, S.; Guo, Y.; Heath, J. R.; Tseng H.-R. “Electrochemical
Fabrication of Conducting Polymer Nanowires in an Integrated Microfluidic System.” Chem. Commun.
2006, 3075–3077.
Sui, G.; Wang, J.; Lee, C.C.; Lee, S. P.; Leyton, J. V.; Wu, A. M.; Tseng H.-R. “Solution-Phase Surface
Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels.” Anal. Chem. 2006, 78, 5543-5551.
Wang, J.; Sui, G.; Mocharla, V. P.; Lin, R. J.; Phelps, M. E.; Kolb, H. C.; Tseng H.-R. “Integrated
Microfluidics for Parallel Screening of In Situ Click Chemistry Library.” Angew. Chem. Int. Ed. 2006, 45,
5276-5281.
Sui, G.; Tseng H.-R. “Reactions in Hand.” Nano Today 2006, 1, 6-7. 21.
Brough, B.; Northrop, B. H.; Schmidt, J. J.; Tseng, H.-R.; Houk, K. N.; Stoddart, J. F.; Ho, C.-M. Evaluation
of Synthetic Linear Motor-molecule Actuation Energetics. Proc. Natl. Acad. Sci. USA. 2006, 103,
8583-8588.
Ferrer, B.; Rogez, G.; Credi, A.; Ballardini, R.; Gandolfi, M. T.; Balzani, V.; Liu, Y.; Tseng, H.-R.; Stoddart, J.
F. “Photoinduced Electron Flow in a Self-Assembling Supramolecular Extension Cable.” Proc. Natl. Acad.
Sci. USA. 2006, 103, 18411-18416
Green, J. E.; Choi, J. W.; Boukai, A. Bunimovich, Y.; Johnston-Halperin, E., DeIonno, E.; Luo, Y.; Sheriff, B.
A. Xu, K.; Shin, Y. S.; Tseng, H.-R.; Stoddart, J. F.; Heath, J. R. “A 160-Kilobit Molecular Electronic
Memory Patterned at 1011 Bits per Square Centimeter” Nature 2007, 445, 414-417
Sui, G.; Lee, C.-C.; Kamei, K.; Li, H.-J.; Wang, J.-Y.; Wang, J.; Herschman, H. R.; Tseng, H.-R. “A
Microfluidic Platform for Sequential Ligand Labeling and Cell Binding Analysis.” Biomedical Microdevices,
2007, 9, 301-305.
Coti, K. K.; Wang, Y.; Wang, J.; Alam, M. M.; Shyue, J.-J.; Yeh, A.; Lu, W.; Padture, N. P.; Tseng, H.-R.
“Individually Addressable Crystalline Conducting polymer Nanowires in a Microelectrode Sensor Array.”
Nanotechnology, 2007, 18, 424021 (7 pp).
Hou, S.; Shen, C. K.-F.; Zeta T. F. Yu, Wang, S.; Fang, X.; Tseng, H.-R. “Hydrodynamically Focused
Stream as a Dynamic Template for Electrochemical Growth of Single Conducting Polymer Nanowires.”
Angew. Chem. Int. Ed. 2008, 47, 1072-1076.
Cotí, K. K.; Wang, Y.; Lin, W.-Y.; Chen, C.-C.; Yu, Z. T. F.; Liu, K.; Shen, C. K.-F.; Selke, M.; Lu, W.; Shen,
C. K.-F.; Yeh, A.; Lu, W.; Tseng, H.-R. “A Dynamic Micromixer for Arbitrary Control of Disguised Chemical
Selectivity.” Chem. Commun., 2008, 3426-3428.
Kamei, K.; Guo, S.; Yu, Z. T. F.; Takahashi H.; Gschweng, E.; Suh C.; Wang, X.; Tang, J.; McLaughlin, J.;
Witte, O. N.; Lee, K.-B.; Tseng, H.-R. “An Integrated Microfluidic Culture Device for Quantitative Analysis of
Human Embryonic Stem Cells.” Lab on a Chip, 2009, 9, 555- 563.
Yu, Z. T. F.; Kamei, K.; Takahashi, H.; Shu, C. J.; Wang, X.; He, G. W.; Silverman, R.; Radu, C. G.; Witte,
O. N.; Lee, K.-B.; Tseng, H.-R. “Integrated Microfluidic Devices for Multiparametric Cell Assays.” Biomed.
Microdevices, 2009, 11, 547-555.
Lin, W.-Y.; Wang, Y.; Lin, Phelps, M. E.; Shen, C. K.-F.; Faull, K.; Tseng, H.-R. “High-Throughput
Screening of in Situ Click Chemical Libraries in Integrated Microfluidic Devices.” Lab on a Chip, 2009, 9,
2281-2285.
Wang, H.; Wang, S.; Su, H.; Chen, K.-J.; Armijo, A. L.; Lin, W.-Y.; Wang, Y.; Czernin, J. Radu, C. R.; and
Tseng H.-R. “A Supramolecular Approach for Preparation of Size-Controllable Nanoparticles.” Angew.
Chem. Int. Ed. 2009, 48, 4344-4348.
Wang, S.; Wang, H.; Kamei, K.; Chen, K.-J.; Sun, J.; Sherman, D.; Owens, G. E.; Jiao, J.; Wu, H.;
Behrenbruch, C. P.; Tseng, H.-R. “Three-Dimensional Nanostructured Substrates toward Efficient Capture
of Circulating Tumor Cells.” Angew. Chem. Int. Ed. 2009, 48, 8970-8973.
24.
25.
Lin, W.-Y.; Wang, Y.; Wang, S.; Tseng, H.-R. “Integrated Microfluidic Reactors.” Nano Today 2009, 4,
470-481.
Jung, J,; Solanki, A.; Memoli, K. A.; Kamei, K.; Kim, H.; Drahl, M. A.; Williams, L. J.; Tseng, H.-R.; Lee,
K.-B. "Selective Inhibition of Human Brain Tumor Cell Proliferation via Multifunctional Quantum dot-Based
siRNA Delivery.” Angew. Chem. Int. Ed. 2009, 48, in press.
C. Research Support
Ongoing Research Support
U54 CA119347-02 (Heath)
9/30/2005 - 8/31/2010
National Cancer Institute
Project 6- Development of microfluidics integrated nanoelectronic sensors as a diagnostic tool for pathologic
analysis of cancer tissues
To develop a stamp-size microfluidic platform, i.e., micro-PathologyLab Chips (μ-PLCs), for multiparameter
analysis of the PI3K signaling pathway in glioblastoma.
Role: co-PI
RT1-01022-1 (Tseng)
California Institute for Regenerative Medicine
3/01/2009 – 2/28/2011
Microfluidic Platform for Screening Chemically Defined Conditions that Facilitate Clonal Expansion of Human
Pluripotent Stem Cells
The goals of our proposal are to develop and validate a robotic microfluidic platform, composed of a robotic liquid
dispensing system, a fluorescence microscope, cell culture chips and operation interface. We will apply such a
robotic platform to perform chemical screening in search of culture conditions and small molecules that will
facilitate single-cell expansion of hPSCs.
Role: PI
R21 EB008419-01 (Tseng)
National Institutes of Health
8/01/2009 – 7/31/2011
Integrated Microfluidic Devices for 18F-Labeled PET Probes in Cancer Imaging
Our idea is to create a modular, automated and user-friendly microfluidic platform capable of synthesizing and
labeling known and novel [18F]-labeled positron emission tomography (PET) imaging probes on demand. The
long term objective of this proposal is to make [18F]-labeled PET probes easily accessible so that researchers
and clinicians can perform a wide range of PET studies targeting specific molecular lesions in cancer.
Role: PI
Completed Research Support
(Graeber)
9/01/2007 – 08/30/2009
Transdisciplinary Award, UCLA Jonsson Comprehensive Cancer Center
An Integrated Microfluidics Platform for the Systems Biology of Cancer
To develop and apply a microfluidics-based in vitro kinase assay for studying the misregulated BCR-ABL
signaling network that drives chronic myelogenous leukemia (CML).
Role: co-PI
W911NF-06-1-0243 (Tseng)
6/15/2006 - 6/14/2009
US Army Research Office
Hydrodynamic Focusing-Templated Electrochemical Fabrication of High Density Conducting Polymer Nanowire
Sensor Arrays
We will perform in-depth investigation of transport properties of the resulting conducting polymer nanowire
electrode junctions (CPNWEJs). We will utilize these high-density CPNWEJ arrays for identification of a wide
range of gas analyte with superb sensitivity and specificity. We will modify conducting polymer nanowires to
interface with living cells for real-time detections of their physiological interactions and responses.
Role: PI
(Tseng)
4/1/2007 - 3/31/2009
UCLA Institute of Stem Cell Biology and Medicine
An Integrated Microfluidic Platform for Screening hESC Culture Conditions
To continue an ongoing collaborative efforts to create an interactive, inter-disciplinary scientific environment in
which experts in microengineering and chemistry join biologists to develop new-generation hESC-Chips for
hESC culture and assays. To test if this technology is amenable to high-throughput screening for culture
conditions that allow enhanced hESC self renewal. To disseminate this technology for routine use in other hESC
laboratories.
Role: PI
DE-FG02-06ER64249 (Phelps)
6/1/2006 - 5/31/2007
Department of Energy
Institute for Molecular Medicine Research Program
Project 1: Identification of Novel PET Imaging Probes to Monitor T Lymphocyte Activation in Cancer and
Autoimmunity.
To test the hypothesis that imaging probes that exploit major metabolic pathways modulated by lymphocyte
activation can be used to generate non-invasive and quantitative correlates of ongoing immune responses
detectable by PET under psychological and pathological conditions.
Role: Co-Investigator
Project 3: Enabling Molecular Technologies for PET.
To first identify high-affinity small molecule binders to proteins that are identified by other members of the
IMED lab as being critical markers for cancer. To investigate two groups - those involved in kinase pathways,
and those that are secreted into the blood. The idea is to take advantages of some of the microfluidics-based
assays that are being developed.
Role: Co-Investigator
Project 5: Technology Development for Preclinical Molecular Imaging.
To develop new technology for the integration of a high resolution, high sensitivity quantitative radiation
imaging detector on a microfluidic chip. This technology will enable much higher sensitivity (log orders) and
much cheaper detection, monitoring of radiochemistry synthesis on a microfluidic chip, as well as various
biological assays involving cell cultures, or the binding of radiolabeled proteins onto different targets.
Role: Co-Investigator
(Tseng)
04/01/2005 – 03/31/2007
CTI Molecular Technology Inc. / Siemens
Producing PET Probes in Chemical reaction circuits (CRCs).
Role: PI
P50 CA086306 (Herschman)
05/01/2005 – 04/30/2007
National Cancer Institute
The UCLA Center for In Vivo Imaging in Cancer Biology
Project 12 – Chemical Reaction Circuits (CRCs) for Radiolabeling of PET Imaging Probes
Role: PI for Developmental Project