Curriculum Vitae
CHUNG-I WU
Education
Institution
Degree Year
Tunghai University, Taiwan B.Sc.
University of British
Ph.D.
Columbia
1976
1982
Field
Biology
Population
Genetics
Employment Experience
7/98 - present Chairman, Dept. of Ecology and Evolution, University of Chicago
7/98 - present Professor, University of Chicago
Primary appointment - Department of Ecology and Evolution
Joint - Dept. of Molecular Genetics & Cell Biology
Joint - Committee on Genetics, Committee on Evolution Biology
7/91 - 6/98
Associate Professor, University of Chicago
9/90 - 6/91
Associate Professor of Biology, University of Rochester
8/86 - 8/90
Assistant Professor of Biology, University of Rochester
1/85 - 7/86
NIH postdoctoral Fellow, Laboratory of Genetics,
University of Wisconsin, Madison
6/82 - 12/84 Senior Research Associate and then Research Instructor,
Center for Demographic and Population Genetics, the
University of Texas, Health Science Center at Houston
9/77 - 4/82
Teaching Assistant/Research Assistant, Department of
Zoology, University of British Columbia, Canada
9/76 - 8/77
Teaching Assistant, Tunghai University, Taiwan
Awards
Research Career Development Award, NIH (10/90 - 9/95)
Fellow, National Down Syndrome Society (6/89 - 5/91)
Academician, Academia Sinica, Taiwan (7/04)
Major grant-reviewing activities
NSF panel on Population Biology (1994)
NIH study section or workshop (July 1990, August 2000, June, July 2001, October 2002,
February, June 2003)
Overseas Reviewing Expert (January 2003 - ) Chinese Academy of Sciences
Active Grants
1. “Analysis of speciation by complex trait mapping”
Chung-I Wu, Principal Investigator
National Institutes of Health
6/1/01 – 5/31/05
Total cost: $1,108,000
2. “Evolution of a new gene, Odysseus, and speciation”
Chung-I Wu, Principal Investigator
1
National Institutes of Health
2/1/03 - 1/30/07
Total cost: $1,005,000
Publications
Papers
Wu, C.-I 1983. The fate of autosomal modifiers of the Sex-Ratio trait in Drosophila and other
sex-linked meiotic drive systems. Theor. Pop. Biol. 24(2):107-120.
Wu, C.-I 1983. Virility selection and the Sex-Ratio trait in Drosophila pseudoobscura: I. Sperm
displacement and sexual selection. Genetics 105(3):651-662.
Wu, C.-I 1983. Virility selection and the Sex-Ratio trait in Drosophila pseudoobscura: II.
Multiple insemination and overall virility selection. Genetics 105(3):663-679.
Wu, C.-I and A.T. Beckenbach 1983. Evidence for extensive genetic differentiation between the
Sex-Ratio and the standard arrangement of Drosophila pseudoobscura and D. persimilis and
identification of hybrid sterility factors. Genetics 105(1):71-86.
Nei, M., T. Maruyama and C.-I Wu 1983. Models of evolution of reproductive isolation.
Genetics 103:557-579.
Li, W.H., C.-I Wu and C.C. Luo 1984. Nonrandomness of point mutation as reflected in
nucleotide substitutions in pseudogenes and its evolutionary implications. J. Mol. Evol. 21:58-71.
Wu, C.-I 1985. A stochastic simulation study on speciation by sexual selection. Evolution 39:6682.
Wu, C.-I and W.H. Li 1985. Evidence for higher rates of nucleotide substitution in rodents than
in man. Proc. Natl. Acad. Sci. 82:1741-1745.
Li, W.H., C.-I Wu and C.C. Luo 1985. A new method for estimating synonymous and
nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide
and codon changes. Mol. Biol. Evol. 2:150-174.
Li, W.H., C.C. Luo and C.-I Wu 1985. Evolution of DNA sequences. In: Molecular Evolutionary
Genetics. R. J. McIntyre (ed.) Plenum, New York. 1-94.
Wu, C.-I, W.H. Li, J.J. Shen, R.C. Scarpulla, K.J. Limbach and R. Wu 1986. Evolution of
cytochrome c genes and pseudogenes. J. Mol. Evol. 23(1):61-75.
Li, W.H. and C.-I Wu. 1987. Rates of nucleotide substitution are evidently higher in rodents than
in man. Mol. Biol. Evol. 4(1):74-77.
Wu, C.-I and N. Maeda 1987. Inequality in mutation rates of the two strands of DNA. Nature
327:169-170.
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Maeda, N., J. B., C.-I Wu, J. Reneke and J. Bliska 1988. Molecular evolution of higher primates:
Intergenic structure, rate and pattern of DNA changes and origin of simple sequences. Mol. Biol.
Evol. 5(1): 1-20.
Wu, C.-I, T. W. Lyttle, M.-L. Wu and G. Lin. 1988. Association between a satellite DNA
sequence and the Responder of Segregation Distorter in D. melanogaster. Cell 54:179-189.
Werren, J. H., U. Nur and C.-I Wu. 1988. Selfish genetic elements. Trends in Ecol. and Evol.
3:297-302.
Wu, C.-I, J. R. True and N. Johnson. 1989. Fitness reduction associated with the deletion of a
satellite DNA array. Nature. 341:248-251.
Wu, C.-I and M. F. Hammer. 1990. Molecular evolution of ultraselfish genes of meiotic drive
systems. In: Evolution at the Molecular Level, Selander, Whittam and Clark (eds.) Sinaur
Press. p. 177-203.
Wu, C.-I 1991. Inference of species phylogeny in relation to segregation of ancient
polymorphisms. Genetics 127(2): 429-435.
Wu, C.-I 1991. Segregation Distorter in Drosophila melanogaster : Responder at the molecular
level. Amer. Natur. 137:314-322.
Lyttle, T. W., C.-I Wu. and S. Howley 1991. Molecular analysis of insect meiosis and sex ratio
distortion. In "Molecular approaches to pure and applied entomology", M. J. Whitten and J. G.
Oakeshott. Springer-Verlag (Berlin)
Doshi, P., S. Kaushal, C. Benyajati and C.-I Wu. 1991. Molecular analysis of the Responder
satellite DNA in Drosophila melanogaster. I. DNA bending, nucleosome spacing, and Rspbinding proteins. Mol. Biol. Evol. 8(5): 721 - 741.
Johnson, N. A. and C-I Wu. 1992. An empirical test of the meiotic drive models of hybrid
sterility: Sex-ratio data from hybrids between Drosophila simulans and D. sechellia. Genetics
130:507-511.
(University of Chicago affiliation below)
Johnson, N. A., D. E. Perez, E. L. Cabot, H. Hollocher and C.-I Wu. 1992. A test of reciprocal
X-Y interactions as a cause of hybrid sterility in Drosophila. Nature 358:751-753.
Wu, C-I. 1992. A note on Haldane’s ruel: Hybrid inviability versus hybrid sterility. Evolution
46(5): 1584-1587.
Wu, C-I, Daniel E. Perez, Andrew W. Davis, Norman A. Johnson, Eric. L. Cabot, Michael F.
Palopoli and M.-L. Wu. 1993. Molecular genetics of reproductive isolation in Drosophila. In:
“Mechanisms of Molecular Evolution” by N. Takahata and A. G. clark (ed.), Sinauer Press.
Wu, C-I. and A. W. Davis. 1993. Evolution of postmating reproductive isolation: The
composite nature of Haldane’s rule and its genetic bases. Amer. Natur. 142:187-212.
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Johnson, N. A. and C.-I Wu. 1993. Evolution of postmating reproductive isolation: measuring
the pleiotropic fitness effects associated with hybrid male sterility factors. Amer. Natur.
142:213-223.
Perez, D. E., C.-I Wu, N. A. Johnson and M.-L. Wu. 1993. Genetics of reproductive isolation in
the Drosophila simulans clade: DNA marker-assisted mapping and characterization of a hybridmale sterility gene, Odysseus (Ods). Genetics 134:261-275.
Johnson, N. J., H. Hollocher, E. Noonberg and C.-I Wu. 1993. The effects of iterspecific Y
chromosome replacements on hybrid sterility within the Drosophila simulans clade: A
comprehensive study. Genetics 135: 443-453.
Cabot, E. L., P. Doshi, M.-L. Wu and C.-I Wu. 1993. Population genetics of tandem repeats in
centromeric heterochromatin: unequal crossing over and interchromosomal divergence at the
Responder locus. Genetics 135: 477-487.
Palopoli, M., P. Doshi and C.-I Wu. 1994 Characterization of two Segregation distorter
revertants: Evidence that the tandem duplication is necessary for the SD phenotype in
Drosophila melanogaster. Genetics 136: 209-215.
Cabot, E. L., A. W. Davis, N. A. Johnson and C.-I Wu. 1994 Genetics of reproductive isolation
in the Drosophila simulans clade: Complex epistasis underlying hybrid sterility. Genetics 137:
175-189.
Davis, A. W., E. Noonberg and C.-I Wu. 1994 Complex genic interactions between conspecific
chromosomes underlying hybrid female serility in the Drosophila simulans clade. Genetics 137:
191-199.
Palopoli, M. and C.-I Wu. 1994 Genetics of hybrid male sterility between Drosophila sibling
species: A complex web of epistasis is revealed in interspecific studies. Genetics 138:329-341.
Wu, C.-I and M. F. Palopoli. 1994 Genetics of postmating reproductive isolation in animals.
Ann. Rev. Genetics 28:283-308.
Perez, D. P. and C-I Wu. 1995 Further characterization of the hybrid sterility gene, Odysseus
(Ods), in the Drosophila simulans clade: one gene is not enough. Genetics 140:201-206.
Wu, C.-I, H. Hollocher, D. Begun, C. F. Aquadro, Y. Xu and M.-L. Wu. 1995 Sexual isolation
in Drosophila melanogaster: A possible case of incipient speciation. Proc. Natl. Acad. Sci.
92:2519-2523.
Davis, A. W., and C.-I. Wu, 1996 The broom of Sorcerer's apprentice: The fine structure of a
chromosomal region causing reproductive isolation between two sibling species of Drosophila.
Genetics 143:1287-1298.
Hollocher, H., and C.-I. Wu., 1996 The genetics of reproductive isolation in the Drosophila
simulans clade: X vs. autosomal effects and male vs. female effects. Genetics 143:1243-1255.
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Wu, C.-I., N. A. Johnson, and M. F. Palopoli, 1996 Haldane's rule and its legacy: why are there
so many sterile males? Trends in Ecol. Evol. 11:281-284.
Palopoli, M. F., and C.-I. Wu, 1996 Rapid evolution of a coadapted gene complex: Evidence
from the Segregation Distorter system of meiotic drive in Drosophila melanogaster. Genetics
143: 1675-1688.
Palopoli, M. F., A. W. Davis, and C.-I. Wu, 1996 Discord between the phylogenies inferred
from molecular vs. functional data: uneven rates of functional evolution or low levels of gene
flow? Genetics 144:1321-1328.
Tsaur, S. C., and C.-I Wu, 1997 Positive selection and the molecular evolution of a gene of male
reproduction. Molec. Biol. Evol. 14:544-549.
Hollocher, H., C.-T. Ting, F. Pollack and C.-I Wu, 1997 Incipient speciation by sexual isolation
in Drosophila melanogaster : Variation in mating preference among antural isolates. Evolution
51: 1175-1181.
Hollocher, H., C.-T. Ting, M.-L. Wu and C.-I Wu, 1997 Incipient speciation by sexual isolation
in Drosophila melanogaster : Extensive divergence without reinforcement. Genetics 147: 11911201.
Tsaur, S. C., C.-T. Ting and C.-I Wu, 1998 Positive selection and the molecular evolution of a
gene of male reproduction, Acp26Aa of Drosophila: II. Divergence vs. polymorphism. Molec.
Biol. Evol. 15:1040 - 1046.
Wu, C.-I., and H. Hollocher, 1998 Subtle is nature: the genetics of species differentiation and
speciation, pp.339-351 in Endless forms: species and speciation, edited by D. Howard and S.
Berlocher. Oxford University Press.
Ting, C.-T., S.-C. Tsaur, M.-L. Wu and C.-I Wu, 1998 A rapidly evolving homeobox at the site
of a hybrid sterility gene. Science 282: 1501-1504.
Fay, J. C. and C.-I Wu, 1999 A human population bottleneck is not incompatible with the
discordance between patterns of mitochondrial vs. nuclear DNA variation. Molec. Biol. Evol.
16:1003 - 1006.
Wyckoff, G. J., W. Wang and C.-I Wu, 2000 Rapid evolution of male reproductive genes in the
descent of man. Nature 403: 304 - 309.
Sawamura, K., A. W. Davis and C.-I Wu, 2000 Genetic analysis by means of introgression into
Drosophila melanogaster. Proc. Natl. Acad. Sci. 97:2652-2655.
Ting, T.-C., S. C. Tsaur, S.-C., and C.-I Wu, 2000 The phylogeny of closely related species as
revealed by the genealogy of a speciation gene, Odysseus. Proc. Natl. Acad. Sci. 97:5313 5316.
Fay, J. C. and C.-I Wu, 2000 Hitchhiking under positive Darwinian selection. Genetics 155:
1405-1413.
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Wu, C.-I, 2000 Genetics of species differentiation: What is unknown and what will be
unknowable? Evol. Biol. 32: 239 - 248. (M. T. Clegg, M. K. Hecht and R. J. MacIntyre, eds.)
Tsaur, S. C., C.-T. Ting and C.-I Wu, 2001 Sex in Drosophila mauritiana: Extremely high level
of replacement polymorphism in a male reproductive gene. Molec. Biol. Evol. 18:22-26
Alipaz, J. A., C-I Wu and T. L. Karr, 2001 Sperm-egg incompatibility between races of
Drosophila. Proc. Roy. Soc. 268:789-795.
Takahashi, A, S.C. Tsaur, J. A. Coyne and C.-I Wu, 2001 The nucleotide changes governing
pheromonal variation in Drosophila and their evolution. Proc. Natl. Acad. Sci.98:3920-3925.
Fay, J. C., G. J. Wyckoff and C.-I Wu, 2001 Positive and negative selection on the human
genome. Genetics 158:1227-1234.
Ting, C.T., A. Takahashi and C.-I Wu, 2001 Incipient speciation by sexual selection: concurrent
evolution at multiple loci. Proc. Natl. Acad. Sci. 98: 6709-6713 (see also Nature 412:31-32)
Luo, Z.W. and C.-I Wu, 2001 Modeling linkage disequilibrium between a polymorphic marker
locus and a locus affecting dichotomous disease traits in natural populations. Genetics 158:
1785-1800.
Wu, C.-I 2001 The genic view of the process of speciation. J. Evol. Biol. 14: 851-865..
Wu, C.-I 2001 Genes and Speciation - A reply. J. Evol. Biol. 14:889-891.
Fay, J. C. and C.-I Wu, 2001 The neutral theory in the genomic era. Curr. Opinion Gen. Dev.
11:642-646.
Fay, J. C., G. J. Wyckoff and C.-I Wu, 2002 Testing the neutral theory of molecular evolution
with genomic data. Nature 415: 1024 - 1026.
Luo, Z.W., C.-I Wu, and M. J. Kearsey, 2002 Precision and high-resolution mapping of
quantitative trait loci by use of recurrent selection, backcross or intercross schemes. Genetics
161: 915-929.
Wyckoff, G. J., J. Li and C.-I Wu, 2002 Molecular evolution of functional genes on the
mammalian Y chromosome. Molec. Biol. Evol. 19: 1633-1636
Fang, S., A. Takahashi, and C.-I Wu, 2002 A mutation in the promoter of desaturase 2 is
correlated with sexual isolation between Drosophila behavioral races. Genetics 168: 781-784.
Wu, C.-I and E. Y. Xu, 2003 Sexual antagonism and X-inactivation - The SAXI hypothesis.
Trends in Genetics 19:243-247.
Fay, J. C., and C.-I. Wu, 2003a Sequence divergence, selective constraint and selection in protein
evolution. Ann. Rev. Genomics Hum. Genet. 4:213-235.
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Fay, J. C., and C.-I. Wu, 2003b Detecting hitchhiking from patterns of DNA polymorphisms in
Selective sweeps, edited by D. I. Nurminsky. Landes Bioscience.
Wang, H-Y., H. Tang, C. K. Shen and C.-I Wu 2003 Rapidly evolving genes in human – I. The
glycophorins and their possible role in evading malaria parasites. Mol. Biol. Evol. 20:17951804.
Greenberg, A. J., J. R. Moran, J. A. Coyne, and Chung-I Wu 2003 Ecological adaptation during
incipient speciation as revealed by precise gene replacement. Science 302: 1754-1757.
Lu, J., W.-H. Li and C.-I Wu. 2003 Chromosomal speciation and gene flow. Science 302:988c.
Wu, C.-I, S. Shi and Y. Zhang 2004 A case for conservation. Nature 428:213-214. (A
commentary in a supplementary issue).
Wu, C.-I and C.-T. Ting 2004 Genes and speciation. Nature Review Genetics 5: 114-122.
He, J et al. (51 authors) 2004. Molecuar evolution of the SARS-conronavirus during the course
of SARS-epidemic in China. Science 303: 1666-1669 (C.-I Wu is a communicating author
for the data analysis section).
Kohn, M. H., S. Fang and C.-I Wu 2004 Inference of positive and negative selection on the 5'
regulatory regions of Drosophila genes. Mol. Biol. Evol. 21:374-383.
Kyoichi Sawamura, John Roote, Chung-I Wu, and Masa-Toshi Yamamoto 2004 Extreme
Genetic Complexity Underlying Hybrid Male Sterility in Drosophila. Genetics 166: 789-796.
Tang, H. , G. J. Wyckoff, J Lu, and C.-I Wu, 2004 A Universal Evolutionary Index for Amino
Acid Changes. Mol. Biol. Evol. 21: 1548-1556.
Ting, C., S. Tsuar, S. Sun, W. Browne, N. Patel and C.-I Wu 2004 Gene duplication and
speciation in Drosophila – Evidence from the Odysseus locus. Proc. Natl. Acad. Sci. 101:
12232-12235.
Sun, S, C. Ting, and C.-I Wu 2004 The normal function of a speciation gene, Odysseus, and its
hybrid sterility effect. Science 305: 81-83.
Osada, N. and C.-I Wu 2005 Testing the mode of speciation with genomic data - Examples from
the great apes. Genetics 169: 259-264.
Song, H.-D. et al. C.-I Wu and G.-P. Zhao 2005 Cross-host evolution of SARS coronavirus in
palm civet and human. Proc. Natl. Acad. Sci. USA 102: 2430-2435
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