Epigenetic Activation of the Foxa2 Gene Is Required for Maintaining

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2014 MRC성과발표회
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< Abstract Sample >
Epigenetic Activation of the Foxa2 Gene Is Required for Maintaining
the Potential of Neural Precursor Cells to Differentiate into
Dopaminergic Neurons after Expansion
So-Young Bang1a, So Hee Kwon2 , Sang-Hoon Yi3, Sang Ah Yi1, Eun Kyung Park1,
Jae-Cheol Lee5, Choon-Gon Jang1, Jueng Soo You4, Sang-Hun Lee3, Jeung-Whan
Han1**
1
Research Center for Epigenome Regulation, School of Pharmacy, Sungkyunkwan
University, Suwon, 440-746, Republic of Korea
2
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei
University, Incheon, 406-840, Republic of Korea
3
Department of Biochemistry and Molecular Biology, College of Medicine, Medical
Research Center, Hanyang University, Seoul, Korea
4
Department of Biochemistry, School of Medicine, Konkuk University, Seoul, 143-
702, Korea;
5Division
Medicine
of Cardiology, Department of Medicine, Stanford University School of
References
1
Meyer AK, Jarosch A, Schurig K, Nuesslein I, Kißenkötter S and Storch A.
(2012). Fetal mouse mesencephalic NPCs generate dopaminergic
neurons from post-mitotic precursors and maintain long-term neural but
not dopaminergic potential in vitro. Brain Res 1474: 8-18.
2
Braak H and Del Tredici K. (2008). Assessing fetal nerve cell grafts in
Parkinson's disease. Nat Med 14: 483-485.
3
Delic J and Zimmermann H. (2010). Nucleotides affect neurogenesis and
dopaminergic differentiation of mouse fetal midbrain-derived neural
precursor cells. Purinergic Signal 6: 417-428.
4
Ostenfeld T and Svendsen CN. (2004). Requirement for neurogenesis to
proceed
through
the
division
of
neuronal
progenitors
following
differentiation of epidermal growth factor and fibroblast growth factor-2responsive human neural stem cells. Stem Cells 22: 798-811.
5
Bouvier MM and Mytilineou C. (1995). Basic fibroblast growth factor
increases division and delays differentiation of dopamine precursors in
vitro. J Neurosci 15: 7141-7149.
6
Studer L, Csete M, Lee SH, Kabbani N, Walikonis J, Wold B and McKay R.
(2000). Enhanced proliferation, survival, and dopaminergic differentiation
of CNS precursors in lowered oxygen. J Neurosci 20: 7377-7383.
7
Yan J, Studer L and McKay RD. (2001). Ascorbic acid increases the yield
of dopaminergic neurons derived from basic fibroblast growth factor
expanded mesencephalic precursors. J Neurochem 76: 307-311.
8
Storch A, Paul G, Csete M, Boehm BO, Carvey PM, Kupsch A, Schwarz J.
(2001). Long-term proliferation and dopaminergic differentiation of human
mesencephalic neural precursor cells. Exp Neurol 170: 317-25.
9
Bayly RD, Brown CY and Agarwala S. (2012). A novel role for FOXA2 and
SHH in organizing midbrain signaling centers. Dev Biol 369: 32-42.
10
Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA and
Ang SL. (2007). Foxa1 and Foxa2 regulate multiple phases of midbrain
dopaminergic neuron development in a dosage-dependent manner.
Development 134: 2761-2769.
11
Norton WH, Mangoli M, Lele Z, Pogoda HM, Diamond B, Mercurio S,
Russell C, Teraoka H, Stickney HL, Rauch GJ, Heisenberg CP, Houart C,
Schilling TF, Frohnhoefer HG, Rastegar S, Neumann CJ, Gardiner RM,
Strähle U, Geisler R, Rees M, Talbot WS and Wilson SW. (2005).
Monorail/Foxa2 regulates floorplate differentiation and specification of
oligodendrocytes, serotonergic raphe neurones and cranial motoneurones.
Development 132: 645-658.
12
Lee HS, Bae EJ, Yi SH, Shim JW, Jo AY, Kang JS, Yoon EH, Rhee YH,
Park CH, Koh HC, Kim HJ, Choi HS, Han JW, Lee YS, Kim J, Li JY,
Brundin P and Lee SH. (2010). Foxa2 and Nurr1 synergistically yield A9
nigral dopamine neurons exhibiting improved differentiation, function, and
cell survival. Stem Cells 28: 501-512.
13
Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G,
Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E,
O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch
R, Nusbaum C, Lander ES and Bernstein BE. (2007). Genome-wide maps
of chromatin state in pluripotent and lineage-committed cells. Nature 448:
553-560.
14 Tanaka Y, Naruse I, Hongo T, Xu M, Nakahata T, Maekawa T and Ishii S.
(2000). Extensive brain hemorrhage and embryonic lethality in a mouse
null mutant of CREB-binding protein. Mech Dev 95: 133-145.
15
Yao TP, Oh SP, Fuchs M, Zhou ND, Ch'ng LE, Newsome D, Bronson RT,
Li E, Livingston DM and Eckner R. (1998). Gene dosage-dependent
embryonic development and proliferation defects in mice lacking the
transcriptional integrator p300. Cell 93: 361-372.
16
MacDonald JL and Roskams AJ. (2008). Histone deacetylases 1 and 2 are
expressed at distinct stages of neuro-glial development. Dev Dyn 237:
2256-2267.
17
Sun G, Fu C, Shen C and Shi Y. (2011). Histone deacetylases in neural
stem cells and induced pluripotent stem cells. J Biomed Biotechnol 2011:
835968.
18
Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW,
Lee HW and Han JW. (2002). Apicidin, a histone deacetylase inhibitor,
induces apoptosis and Fas/Fas ligand expression in human acute
promyelocytic leukemia cells. J Biol Chem 277: 2073-2080.
19
You JS, Kang JK, Seo DW, Park JH, Park JW, Lee JC, Jeon YJ, Cho EJ
and Han JW. (2009). Depletion of embryonic stem cell signature by
histone deacetylase inhibitor in NCCIT cells: involvement of Nanog
suppression. Cancer Res 69: 5716-5725.
20
Deierborg T, Soulet D, Roybon L, Hall V and Brundin P. (2008). Emerging
restorative treatments for Parkinson's disease. Prog Neurobiol 85: 407-432.
21
Morizane A1, Li JY and Brundin P. (2008). From bench to bed: the
potential of stem cells for the treatment of Parkinson's disease. Cell Tissue
Res 331: 323-336.
22
Anthony C, Vernon, Edward J, Smith, Lara Stevanato and Michel Modo.
(2011). Selective activation of metabotropic glutamate receptor 7 induces
inhibition of cellular proliferation and promotes astrocyte differentiation of
ventral mesencephalon human neural stem/progenitor cells. Neurochem
Int 59:421-431.
23 Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP,
Wang S, Morton CC, McMahon AP, Powers D and Melton DA. (2004).
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J
Med 350: 1353-1356.
24
Herszfeld D, Wolvetang E, Langton-Bunker E, Chung TL, Filipczyk AA,
Houssami S, Jamshidi P, Koh K, Laslett AL, Michalska A, Nguyen L,
Reubinoff BE, Tellis I, Auerbach JM, Ording CJ, Looijenga LH and Pera MF.
(2006). CD30 is a survival factor and a biomarker for transformed human
pluripotent stem cells. Nat Biotechnol 24: 351-357.
25
Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G,
Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X,
Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui S, Carpenter
M, Gazdar AF, Rao M and Chakravarti A. (2005). Genomic alterations in
cultured human embryonic stem cells. Nat Genet 37: 1099-1103.
26
Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E and
Svendsen CN. (2000). Human neural precursor cells express low levels of
telomerase in vitro and show diminishing cell proliferation with extensive
axonal outgrowth following transplantation. Exp Neurol 164: 215-226.
27 Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki
H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL. (2009).
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a
and
Lmx1b
in
a
feedforward
loop
promoting
mesodiencephalic
dopaminergic neuron development. Dev Biol 333: 386-396.
28
Kittappa R, Chang WW, Awatramani RB and McKay RD. (2007). The
foxa2 gene controls the birth and spontaneous degeneration of dopamine
neurons in old age. PLoS Biol 5: e325.
29
Kim HJ. (2011). Stem cell potential in Parkinson’s disease and molecular
factors for the generation of dopamine neurons. Biochim Biophys Acta
1812: 1-11.
30
Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P,
Karmiol S and Dunnett SB. (1997). Long-term survival of human central
nervous system progenitor cells transplanted into a rat model of
Parkinson's disease. Exp Neurol 148: 135-146.
31
Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A . (2007). PHA4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature.
447:550-555.
32 Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter
W, Verdin E. (2002). Enzymatic activity associated with class II HDACs is
dependent on a multiprotein complex containing HDAC3 and SMRT/NCoR. Mol Cell 9: 45-57.
33 Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B,
Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber
SL and Lander ES. (2006). A bivalent chromatin structure marks key
developmental genes in embryonic stem cells. Cell 125: 315-326.
34
Greenway DJ, Street M, Jeffries A and Buckley NJ. (2007). RE1 Silencing
transcription factor maintains a repressive chromatin environment in
embryonic hippocampal neural stem cells. Stem Cells 25: 354-363.
35
Siebzehnrubl FA, Buslei R, Eyupoglu IY, Seufert S, Hahnen E and
Blumcke I. (2007). Histone deacetylase inhibitors increase neuronal
differentiation in adult forebrain precursor cells. Exp Brain Res 176: 672-
678.
36
Chen PS, Peng GS, Li G, Yang S, Wu X, Wang CC, Wilson B, Lu RB,
Gean PW, Chuang DM and Hong JS. (2006). Valproate protects
dopaminergic neurons in midbrain neuron/glia cultures by stimulating the
release of neurotrophic factors from astrocytes. Mol Psychiatry 11: 11161125.
37
Go HS, Seo JE, Kim KC, Han SM, Kim P, Kang YS, Han SH, Shin CY and
Ko KH. (2011). Valproic acid inhibits neural progenitor cell death by
activation of NF-kappaB signaling pathway and up-regulation of Bcl-XL. J
Biomed Sci 18: 48.
38
Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA and Helin K.
(2008). Coordinated regulation of transcriptional repression by the RBP2
H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev 22:
1345-1355.
39
Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM,
Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe
K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM,
Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK,
Jaenisch R and Young RA. (2006). Control of developmental regulators by
Polycomb in human embryonic stem cells. Cell 125: 301-313.
40
Sher F, Rössler R, Brouwer N, Balasubramaniyan V, Boddeke E and
Copray
S.
(2008).
Differentiation
of
neural
stem
cells
into
oligodendrocytes: involvement of the polycomb group protein Ezh2. Stem
Cells 26: 2875-2883.
41
Donato R, Miljan EA, Hines SJ, Aouabdi S, Pollock K, Patel S, Edwards FA
and Sinden JD (2007). Differential development of neuronal physiological
responsiveness in two human neural stem cell lines. BMC Neuroscience
25:8-36.
Keywords
Neural stem cell, Dopaminergic neuron, Epigenetic regulation, Foxa2, HDAC7,
Apicidin
2014
MRC 성과발표회
Name : 방소영
Affiliation : 성균관대학교 약학대학
Position : 대학원생 (석박통합과정)
Pi
E-mail : highsy95@gmail.com
t
ure
Field of Expertise : Epigenetic
Education :
2005-2010 B.S.
건국대학교 응용생화학과
2011-현재 성균관대학교 약학대학 석박통합과정 재학 중
Professional Experience : (less than 5 experiences)
Selected Publications : (less than 5 papers)
Epigenetic Activation of the Foxa2 Gene Is Required for Maintaining the Potential of Neural
Precursor Cells to Differentiate into Dopaminergic Neurons after Expansion. Stem Cells
Dev. 2014 Sep 18.
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