Publication List of Dr. Kwon-Chung, K. J. (2000~ )
Bemis, D. A., Krahwinkel, D. J., Bowman, L. A., Mondon, P., and Kwon-Chung, K. J. (2000).
Temperature-sensitive strain of Cryptococcus neoformans producing hyphal elements in a
feline nasal granuloma. J Clin Microbiol 38, 926-928.
Chang, Y. C., Bien, C. M., Lee, H., Espenshade, P. J., and Kwon-Chung, K. J. (2007). Sre1p, a regulator
of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus
neoformans. Mol Microbiol 64, 614-629.
Chang, Y. C., Jong, A., Huang, S., Zerfas, P., and Kwon-Chung, K. J. (2006). CPS1, a homolog of the
Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the
pathobiology of Cryptococcus neoformans. Infect Immun 74, 3930-3938.
Chang, Y. C., Miller, G. F., and Kwon-Chung, K. J. (2003). Importance of a developmentally regulated
pheromone receptor of Cryptococcus neoformans for virulence. Infect Immun 71, 4953-4960.
Chang, Y. C., Penoyer, L. A., and Kwon-Chung, K. J. (2001). The second STE12 homologue of
Cryptococcus neoformans is MATa-specific and plays an important role in virulence. Proc Natl
Acad Sci U S A 98, 3258-3263.
Chang, Y. C., Stins, M. F., McCaffery, M. J., Miller, G. F., Pare, D. R., Dam, T., Paul-Satyaseela, M., Kim,
K. S., and Kwon-Chung, K. J. (2004a). Cryptococcal yeast cells invade the central nervous
system via transcellular penetration of the blood-brain barrier. Infect Immun 72, 4985-4995.
Chang, Y. C., Tsai, H. F., Karos, M., and Kwon-Chung, K. J. (2004b). THTA, a thermotolerance gene of
Aspergillus fumigatus. Fungal Genet Biol 41, 888-896.
Chang, Y. C., Wickes, B. L., Miller, G. F., Penoyer, L. A., and Kwon-Chung, K. J. (2000). Cryptococcus
neoformans STE12alpha regulates virulence but is not essential for mating. J Exp Med 191,
871-882.
Chang, Y. C., Wright, L. C., Tscharke, R. L., Sorrell, T. C., Wilson, C. F., and Kwon-Chung, K. J. (2004c).
Regulatory roles for the homeodomain and C2H2 zinc finger regions of Cryptococcus
neoformans Ste12alphap. Mol Microbiol 53, 1385-1396.
Chen, J., Varma, A., Diaz, M. R., Litvintseva, A. P., Wollenberg, K. K., and Kwon-Chung, K. J. (2008).
Cryptococcus neoformans strains and infection in apparently immunocompetent patients,
China. Emerg Infect Dis 14, 755-762.
Chen, S. H., Stins, M. F., Huang, S. H., Chen, Y. H., Kwon-Chung, K. J., Chang, Y., Kim, K. S., Suzuki, K.,
and Jong, A. Y. (2003). Cryptococcus neoformans induces alterations in the cytoskeleton of
human brain microvascular endothelial cells. J Med Microbiol 52, 961-970.
Chung, S., Karos, M., Chang, Y. C., Lukszo, J., Wickes, B. L., and Kwon-Chung, K. J. (2002). Molecular
analysis of CPRalpha, a MATalpha-specific pheromone receptor gene of Cryptococcus
neoformans. Eukaryot Cell 1, 432-439.
Chung, S., Mondon, P., Chang, Y. C., and Kwon-Chung, K. J. (2003). Cryptococcus neoformans with
a mutation in the tetratricopeptide repeat-containing gene, CCN1, causes subcutaneous
lesions but fails to cause systemic infection. Infect Immun 71, 1988-1994.
Fu, Y., Lee, H., Collins, M., Tsai, H. F., Spellberg, B., Edwards, J. E., Jr., Kwon-Chung, K. J., and Ibrahim,
A. S. (2004). Cloning and functional characterization of the Rhizopus oryzae high affinity iron
permease (rFTR1) gene. FEMS Microbiol Lett 235, 169-176.
Fujii, I., Yasuoka, Y., Tsai, H. F., Chang, Y. C., Kwon-Chung, K. J., and Ebizuka, Y. (2004). Hydrolytic
polyketide shortening by ayg1p, a novel enzyme involved in fungal melanin biosynthesis. J
Biol Chem 279, 44613-44620.
Garcia-Rivera, J., Chang, Y. C., Kwon-Chung, K. J., and Casadevall, A. (2004). Cryptococcus
neoformans CAP59 (or Cap59p) is involved in the extracellular trafficking of capsular
glucuronoxylomannan. Eukaryot Cell 3, 385-392.
Gupta, S. et al. (2007). Successful treatment of disseminated fusariosis with posaconazole during
neutropenia and subsequent allogeneic hematopoietic stem cell transplantation. Transpl
Infect Dis 9, 156-160.
Holland, S. M., Shea, Y. R., and Kwon-Chung, J. (2004). Regarding "Trichosporon pullulans infection
in 2 patients with chronic granulomatous disease". J Allergy Clin Immunol 114, 205-206;
author reply 206.
Jong, A., Wu, C. H., Chen, H. M., Luo, F., Kwon-Chung, K. J., Chang, Y. C., Lamunyon, C. W., Plaas, A.,
and Huang, S. H. (2007). Identification and characterization of CPS1 as a hyaluronic acid
synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot
Cell 6, 1486-1496.
Jong, A., Wu, C. H., Prasadarao, N. V., Kwon-Chung, K. J., Chang, Y. C., Ouyang, Y., Shackleford, G.
M., and Huang, S. H. (2008a). Invasion of Cryptococcus neoformans into human brain
microvascular endothelial cells requires protein kinase C-alpha activation. Cell Microbiol.
Jong, A., Wu, C. H., Shackleford, G. M., Kwon-Chung, K. J., Chang, Y. C., Chen, H. M., Ouyang, Y.,
and Huang, S. H. (2008b). Involvement of human CD44 during Cryptococcus neoformans
infection of brain microvascular endothelial cells. Cell Microbiol 10, 1313-1326.
Karos, M., Chang, Y. C., McClelland, C. M., Clarke, D. L., Fu, J., Wickes, B. L., and Kwon-Chung, K. J.
(2000). Mapping of the Cryptococcus neoformans MATalpha locus: presence of mating typespecific mitogen-activated protein kinase cascade homologs. J Bacteriol 182, 6222-6227.
Kidd, S. E. et al. (2004). A rare genotype of Cryptococcus gattii caused the cryptococcosis
outbreak on Vancouver Island (British Columbia, Canada). Proc Natl Acad Sci U S A 101,
17258-17263.
Kwon-Chung, K. J., Sorrell, T. C., Dromer, F., Fung, E., and Levitz, S. M. (2000). Cryptococcosis:
clinical and biological aspects. Med Mycol 38 Suppl 1, 205-213.
Kwon-Chung, K. J., and Varma, A. (2006). Do major species concepts support one, two or more
species within Cryptococcus neoformans? FEMS Yeast Res 6, 574-587.
Lee, H., Bien, C. M., Hughes, A. L., Espenshade, P. J., Kwon-Chung, K. J., and Chang, Y. C. (2007a).
Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus
Cryptococcus neoformans. Mol Microbiol 65, 1018-1033.
Lee, H., Chang, Y. C., and Kwon-Chung, K. J. (2005). TUP1 disruption reveals biological differences
between MATa and MATalpha strains of Cryptococcus neoformans. Mol Microbiol 55, 12221232.
Lee, H., Chang, Y. C., Nardone, G., and Kwon-Chung, K. J. (2007b). TUP1 disruption in Cryptococcus
neoformans uncovers a peptide-mediated density-dependent growth phenomenon that
mimics quorum sensing. Mol Microbiol 64, 591-601.
Loftus, B. J. et al. (2005). The genome of the basidiomycetous yeast and human pathogen
Cryptococcus neoformans. Science 307, 1321-1324.
Lupo, P., Chang, Y. C., Kelsall, B. L., Farber, J. M., Pietrella, D., Vecchiarelli, A., Leon, F., and KwonChung, K. J. (2008). The presence of capsule in Cryptococcus neoformans influences the gene
expression profile in dendritic cells during interaction with the fungus. Infect Immun 76,
1581-1589.
McClelland, C. M., Chang, Y. C., and Kwon-Chung, K. J. (2005). High frequency transformation of
Cryptococcus neoformans and Cryptococcus gattii by Agrobacterium tumefaciens. Fungal
Genet Biol 42, 904-913.
McClelland, C. M., Chang, Y. C., Varma, A., and Kwon-Chung, K. J. (2004). Uniqueness of the mating
system in Cryptococcus neoformans. Trends Microbiol 12, 208-212.
Mondon, P., Chang, Y. C., Varma, A., and Kwon-Chung, K. J. (2000). A novel episomal shuttle vector
for transformation of Cryptococcus neoformans with the ccdB gene as a positive selection
marker in bacteria. FEMS Microbiol Lett 187, 41-45.
Moyrand, F., Chang, Y. C., Himmelreich, U., Kwon-Chung, K. J., and Janbon, G. (2004). Cas3p
belongs to a seven-member family of capsule structure designer proteins. Eukaryot Cell 3,
1513-1524.
Okoli, I., Oyeka, C. A., Kwon-Chung, K. J., Theelen, B., Robert, V., Groenewald, J. Z., McFadden, D. C.,
Casadevall, A., and Boekhout, T. (2007). Cryptotrichosporon anacardii gen. nov., sp. nov., a
new trichosporonoid capsulate basidiomycetous yeast from Nigeria that is able to form
melanin on niger seed agar. FEMS Yeast Res 7, 339-350.
Pardo, J. et al. (2006). The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and
a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 174, 509-519.
Petter, R., Kang, B. S., Boekhout, T., Davis, B. J., and Kwon-Chung, K. J. (2001). A survey of
heterobasidiomycetous yeasts for the presence of the genes homologous to virulence factors
of Filobasidiella neoformans, CNLAC1 and CAP59. Microbiology 147, 2029-2036.
Roh, M. L., Tuazon, C. U., Mandler, R., Kwon-Chung, K. J., and Geist, C. E. (2005). Sphenocavernous
syndrome associated with Schizophyllum commune infection of the sphenoid sinus. Ophthal
Plast Reconstr Surg 21, 71-74.
Segal, B. H., Kwon-Chung, J., Walsh, T. J., Klein, B. S., Battiwalla, M., Almyroudis, N. G., Holland, S.
M., and Romani, L. (2006). Immunotherapy for fungal infections. Clin Infect Dis 42, 507-515.
Sugui, J. A., Chang, Y. C., and Kwon-Chung, K. J. (2005). Agrobacterium tumefaciens-mediated
transformation of Aspergillus fumigatus: an efficient tool for insertional mutagenesis and
targeted gene disruption. Appl Environ Microbiol 71, 1798-1802.
Sugui, J. A. et al. (2007a). Role of laeA in the Regulation of alb1, gliP, Conidial Morphology, and
Virulence in Aspergillus fumigatus. Eukaryot Cell 6, 1552-1561.
Sugui, J. A. et al. (2007b). Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion
attenuates virulence in mice immunosuppressed with hydrocortisone. Eukaryot Cell 6, 15621569.
Tsai, H. F., Fujii, I., Watanabe, A., Wheeler, M. H., Chang, Y. C., Yasuoka, Y., Ebizuka, Y., and KwonChung, K. J. (2001). Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chainlength shortening of a heptaketide precursor. J Biol Chem 276, 29292-29298.
Tscharke, R. L., Lazera, M., Chang, Y. C., Wickes, B. L., and Kwon-Chung, K. J. (2003). Haploid fruiting
in Cryptococcus neoformans is not mating type alpha-specific. Fungal Genet Biol 39, 230-237.
Varma, A., and Kwon-Chung, K. J. (2000). Characterization of the L41 gene in Cryptococcus
neoformans: its application as a selectable transformation marker for cycloheximide resistance.
Yeast 16, 1397-1403.
Varma, A., Wu, S., Guo, N., Liao, W., Lu, G., Li, A., Hu, Y., Bulmer, G., and Kwon-Chung, K. J. (2006).
Identification of a novel gene, URE2, that functionally complements a urease-negative clinical
strain of Cryptococcus neoformans. Microbiology 152, 3723-3731.
Watanabe, A., Fujii, I., Tsai, H., Chang, Y. C., Kwon-Chung, K. J., and Ebizuka, Y. (2000). Aspergillus
fumigatus alb1 encodes naphthopyrone synthase when expressed in Aspergillus oryzae. FEMS
Microbiol Lett 192, 39-44.
Wilder, J. A., Olson, G. K., Chang, Y. C., Kwon-Chung, K. J., and Lipscomb, M. F. (2002).
Complementation of a capsule deficient Cryptococcus neoformans with CAP64 restores
virulence in a murine lung infection. Am J Respir Cell Mol Biol 26, 306-314.
Wynne, S. M., Kwon-Chung, K. J., Shea, Y. R., Filie, A. C., Varma, A., Lupo, P., and Holland, S. M.
(2004). Invasive infection with Trichosporon inkin in 2 siblings with chronic granulomatous
disease. J Allergy Clin Immunol 114, 1418-1424.
Zarember, K. A., Sugui, J. A., Chang, Y. C., Kwon-Chung, K. J., and Gallin, J. I. (2007). Human
polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrinmediated iron depletion. J Immunol 178, 6367-6373.