SHANGBIN YANG
Address: 4577 Olentangy River Road, A partment 214, Columbus, Ohio 43214
Mobile: 614.373.2767 E-mail: shangbiny@gmail.com
RESEARCH SCIENTIST
Q UALIFICATIONS P ROFILE
Detail-oriented, highly analytical, and accomplished professional, with extensive years of experience within the
clinical and research fields. Proficient with routine laboratory work, including cellular and molecular experiments;
complemented with well-honed knowledge in test and assay development and validation. Armed with the ability
to gather accurate information; apply necessary procedures; and ensure the efficient completion of every assigned
task. Capable of working independently or collaboratively as part of team. Equipped with excellent
communication, analysis, leadership, and interpersonal skills. Bilingual in English and Mandarin Chinese.
Technically well-versed in using Microsoft Office Suite (Word, PowerPoint, and Excel) and SPSS.
C AREER -R ELATED E XPERTISE
Research Formulation and Documentation | Blood Sampling | Assay Establishment and Validation
Technical Support | Team Building | Reports Analysis | Staff Coordination
Laboratory Skills:
DNA/RNA
Protein
Cell Culture
Coagulation
Clinical Test
Development and
Validation
DNA/RNA Extraction | Plasmids Construction | RT-PCR
Protein Expression in E. coli | His and GST Tagged Protein Purification | Western Blot | 2D PAGE and Analysis
Cell Culture | Cell Growth Curve | Colony Formation Assay | Focus Formation Assay |
Reporter Assay
Blood banking, Diluted PTT assay, Cell coated PTT assay
Surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) mass
spectrometry
 ADAMTS13 activity and inhibitor titer assays
 Low ADAMTS13 activity assay
 Rapid multiplexed genotyping of single nucleotide polymorphisms for hereditary
thrombophilia and influencing warfarin drug response
Agarose gel electrophoresis and western blot
 Von Willebrand Factor multimer assay
AggRAM analyzer
 Von Willebrand factor ristocetin cofactor [VWF:RCo] assay
Enzyme-linked immunosorbent assay (ELISA)
 Human complement C3a, C4d, Bb and SC5b-9 levels by kits from Quidel and C5a by
using kit from B&D
 Human MCP-1 level in urine samples by kit from R&D system
E DUCATION
Doctor of Philosophy (Ph.D.) in Cell and Molecular Biology
Laboratory of Cell and Molecular Biology, Cancer Institute and Cancer Hospital
China Academy of Chinese Medical Sciences (CACMS)
Peking Union Medical College
Tsinghua University, Beijing, China
Sep 2002–Jul 2007
Bachelor of Science, Major in Virology
Department of Virology, Academy of Life Sciences, Wuhan University, Hubei, China
Sep 1998–Jul 2002
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SHANGBIN YANG
Address: 4577 Olentangy River Road, A partment 214, Columbus, Ohio 43214
Mobile: 614.373.2767 E-mail: shangbiny@gmail.com
P ROFESSIONAL E XPERIENCE
Department of Pathology, The Ohio State University | Columbus, OH
Clinical Coagulation Laboratory
Research Scientist
Jan 2013–Present
Postdoctoral Researcher
Oct 2007–Dec 2012
Assume full responsibility in providing technical support to all clinical tests conducted by the Clinical Coagulation
Laboratory as well as all research projects and new tests development and validation.
Notable Achievements:
– Successfully published eight papers; one patent filed and seven clinical tests developed and validated.
– Created one novel entitled as rapid multiplexed genotyping of single nucleotide polymorphisms for hereditary
thrombophilia and influencing warfarin drug response by SELDI-TOF mass spectrometry which was reported by
more than 10 public media.
P ROFESSIONAL A FFILIATION
American Society of Hematology | 2007–Present
A DDENDUM
Oral Presentations
Wu, T.C., Yang, S., Haven, S., Holers, V.M., Lundberg, A.S., Wu, H., and Cataland, S.R. (2012) Mortality from
thrombotic thrombocytopenic purpura is related to complement hyperactivation. The Annual Meeting of the
American Society of Hematology, Atlanta, GA.
Biller, B., Yang, S., and Wu, H., (2011) Longitudinal characterization of ADAMTS13 activity and antibody profile in
thrombotic thrombocytopenic purpura arising in a background of systemic lupus erythematosus. American Society
for Apheresis (ASFA), Scottsdale, AZ.
Cataland, S.R., Peyvandi, F., Mannucci, P.R., Lämmle, B., Hovinga, J.K, Machin, S.J… Jilma, B. (2010) A randomized,
double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic
purpura (TTP). The Annual Meeting of the American Society of Hematology, Orlando, FL.
Jin, M., Yang, S., and Wu, H.M, (2010). Novel application of SELDI-TOF mass spectrometer in genotyping and
personalized medicine. 99th Annual Meeting of the United States and Canadian Academy of Pathology,
Washington, DC.
Jin, M., Yang, S., and Wu, H.M. (2010). Biochemical characteristics of ADAMTS13 antibody inhibitors and the clinical
implications. ASFA New Orleans, LA.
Wu, H., Jin, M., Haven, S., Yang, S., (2010) New insights from longitudinal analysis of VWF multimeric patterns in TTP.
American Society for Apheresis, New Orleans, LA.
Wu, H., Yang, S., (2010). Relationship between ADAMTS13 antibody property and TTP's clinical outcomes. American
Association of Blood Banks (AABB), Baltimore, MA.
Yang, S., Haven, S., Jin, M., Geyer, S., Cataland, S.R., and Wu, H., (2010). Longitudinal analysis of VWF
multimerization patterns in a large TTP Cohort. The Annual Meeting of the American Society of Hematology,
Orlando, FL.
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SHANGBIN YANG
Address: 4577 Olentangy River Road, A partment 214, Columbus, Ohio 43214
Mobile: 614.373.2767 E-mail: shangbiny@gmail.com
Yang, S., Jin, M., Lin, S., Cataland, S. R., and Wu, H. M., (2009). Longitudinal performances of ADAMTS13 antigen and
activity over the course of idiopathic TTP. International Society on Thrombosis and Haemostasis (ISTH)
Congress, Boston, MA.
Cataland, S. R., Yang, S., Witkoff, L., Kraut, E. H., Lin, S., George, J. N., and Wu, H. M., (2009). ADAMTS13 activity,
race, and age as predictors of exacerbation in patients with TTP. ISTH Congress, Boston, MA.
Cataland, S.R., Yang, S., Horne, A., Lin, S., George, J., and Wu, H., (2008). Lower ADAMTS13 activity and higher
Bethesda units of antibody inhibitor in early remission are associated with a higher probability of TTP exacerbation.
50th American Society of Hematology (ASH) Annual Meeting, San Francisco, CA
Poster Presentations
Yang S, Cataland S.R., Holers V.M., Lundberg A.S., and Wu H., (2012) Complement activation in patients with acquired
thrombotic thrombocytopenic pupura (TTP). The Annual Meeting of the American Society of Hematology,
Atlanta, GA.
Wu, H., Biller, E., Yang, S., Kraut, E.H., Cataland, S., and Geyer, S., (2010) Comparison of clinical outcomes between
initial and relapsed events of thrombotic thrombocytopenic purpura in a large TTP cohort. The Annual Meeting of
the American Society of Hematology, Orlando, FL.
Yang S. and Wu H. M., (2010). Longitudinal characterization of a recurring case of TTP with history of HIV. American
Society for Apheresis (ASFA), New Orleans, LA.
Yang, S. and Wu, H., (2009). Novel application of SELDI-TOF mass spectrometer in genotyping and personalized medicine.
The 8th Annual Ohio State University Medical Center (OSUMC) Columbus, OH.
Publications
Wu TC, Yang S, Haven S, Holers VM, Lundberg AS, Wu H, Cataland SR. (2013) Complement Activation and
Mortality During an Acute Episode of Thrombotic Thrombocytopenic Purpura. J Thromb Haemost. [Epub
ahead of print] (Journal impact factor: 6.081)
Liu M., Zhu H., Yang S., Wang Z., Bai J., Xu N. (2013). c-Myc suppressed E-cadherin through miR-9 at the posttranscriptional level. Cell Biol Int, 37, 197-202. (Journal impact factor: 1.640)
Lotta, L.A., Wu, H.M., Mackie I.J., Noris, M., Veyradier, A., Scully, M.A…Peyvandi, F. (2012). Residual plasmatic
activity of ADAMTS13 correlates with phenotype severity in congenital thrombotic thrombocytopenic
purpura. Blood, 120, 440-448. (Journal impact factor: 9.060)
Cataland, S.R., Peyvandi, F., Mannucci, P.M., Lämmle, B., Kremer Hovinga J.A., Machin, S.J…Knoebl P. (2012).
Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients
with thrombotic thrombocytopenic purpura. Am J Hematol, 87, 430-432. (Journal impact factor: 4.003)
Cataland, S.R., Yang, S., Wu, H.M. (2012). The use of ADAMTS13 activity, platelet count, and serum creatinine to
differentiate acquired thrombotic thrombocytopenic purpura from other thrombotic microangiopathies. Br
J Haematol, 157, 501-503. (Journal impact factor: 4.942)
Zhang, J., Lou, X., Yang, S., He, S., Yang, L., Liu, M…Liu, S. (2012). BAG2 is a target of the c-Myc gene and is involved in
cellular senescence via the p21(CIP1) pathway. Cancer Lett, 318, 34-41. (Journal impact factor: 4.258)
Liu, M., Wang, Z., Yang, S., Zhang, W., He, S., Hu, C…Xu, N. (2011). TNF-α is a novel target of miR-19a. Int J Oncol,
38, 1013-1022. (Journal impact factor: 2.657)
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SHANGBIN YANG
Address: 4577 Olentangy River Road, A partment 214, Columbus, Ohio 43214
Mobile: 614.373.2767 E-mail: shangbiny@gmail.com
Raman, R., Yang, S., Wu, H.M., Cataland, S.R. (2011). ADAMTS13 activity and the risk of thrombotic
thrombocytopenic purpura relapse in pregnancy. Br J Haematol, 153, 277-279. (Journal impact factor: 4.942)
Yang, S., Jin, M., Lin, S., Cataland, S., Wu, H. (2011). ADAMTS13 activity and antigen during therapy and followup of patients with idiopathic thrombotic thrombocytopenic purpura: Correlation with clinical outcome.
Haematologica, 96, 1521-1527. (Journal impact factor: 5.935)
He, S., Yang, S., Deng, G., Liu, M., Zhu, H., Zhang, W…Xu, N. (2010). Aurora kinase A induces miR-17-92 cluster
through regulation of E2F1 transcription factor. Cell Mol Life Sci, 67, 2069-2076. (Journal impact factor: 5.615)
Zhang, W., Yan, S., Liu, M., Zhang, G., Yang S., He, S…Xu, N. (2010). Beta-Catenin/TCF pathway plays a vital role
in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells.
Cancer Lett, 296, 113-122. (Journal impact factor: 4.258)
Yang, S., He, S., Zhou, X., Liu, M., Zhu, H., Wan,g Y…Xu, N. (2010). Suppresion of Aurora-A oncogenic potentials
by c-Myc downregulation. Exp Mol Med, 42, 759-767. (Journal impact factor: 2.573)
Yang S., Xu L., Wu H. (2010). Rapid multiplexed genotyping for hereditary thrombophilia by SELDI-TOF mass
spectrometry. Diagn Mol Pathol, 19, 54-61. (Journal impact factor: 1.861)
Liu, M., Yang, S., Wang, Y., Zhu, H., Yan, S., Zhang, W…Xu, N. (2009). EB1 acts as an oncogene via activating betacatenin/TCF pathway to promote cellular growth and inhibit apoptosis. Mol Carcinog, 48, 212-219. (Journal
impact factor: 4.269)
Cataland, S.R., Yang, S.B., Witkoff, L., Kraut, E.H., Lin, S., George, J.N., and Wu, HM. (2009). Demographic and
ADAMTS13 biomarker data as predictors of early recurrences of idiopathic thrombotic thrombocytopenic
purpura. Eur J Haematol, 83, 559-564. (Journal impact factor: 2.548)
Zhang G., Zhu H., Wang Y., Yang S., Liu M., Zhang W…Xu N. (2009). Krüppel-like factor 4 represses the transcription of
surviving gene in esophageal cancer cell lines. Biol Chem, 390:463-469. (Journal impact factor: 2.683)
Yan, S., Zhou, C., Zhang, W., Zhang, G., Zhao, X., Yang, S…Xu, N. (2008). Beta-Catenin/TCF pathway up regulates
STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett, 271:85-97. (Journal impact
factor: 4.258)
Yang S., Xu L., Wu H.M. (2008). Rapid genotyping of single-nucleotide polymorphisms influencing Warfarin drug
response by surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) mass
spectrometry. J Mol Diagn, 12(2), 162-168. (Journal impact factor: 3.952)
Yang, S., Zhou, XB., Zhu, HX., Quan, L.P., Bai, J.F., He, J…Xu, NZ. (2007). Amplification and overexpression of
Aurora-A in esophageal squamous cell carcinoma. Oncol Rep, 17, 1083-1088. (Journal impact factor: 2.297)
Huang, M., Wang, Y., Sun, D., Zhu, H., Yin, Y., Zhang, W…Xu, N,. (2006). Identification of genes regulated by
Wnt/β-catenin pathway and involved in apoptosis via microarray analysis. BMC Cancer, 6, 221. (Journal
impact factor: 3.333)
Patent
Wu H., Yang, S., and Xu L. (2008). U.S. Patent No. 157,812. (Patent pending)
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