Emiko Mizoguchi, M.D., Ph.D.
Department of Medicine
Harvard Medical School
Boston, MA
Contact
Gastrointestinal Unit, GRJ 825D
Massachusetts General Hospital
55 Fruit Street
Boston MA 02114-2696
Phone: (617) 726-7892
Fax: (617) 726-3673
E-mail: emizoguchi@partners.org
Honors and Accolades
 Member, Board of Editors, Chemical Rapid Communications (Research Publisher Inc.), (2012-present)
 Member, Tumor Microenvironment (TME) Study Section, NIH Oncology Research Grants (2012)
 Academic Editor, PLoS ONE (Public Library of Science, Cambridge, UK), (2011-present)
 Member, Board of Editors, Gastroenterology and Hepatology (Canadian Research & Developmental Center for Science
and Culture, Montreal, Canada), (2011-present)
 Member, Board of Editors, International Scholarly Research Network Immunology (New York, NY), (2011-present)
 Administrative Supplemental Award, NIH American Recovery and Reinvestment Act (2009-2010)
 Member, Minority Biomedical Research Support, National Institute of General Medical Sciences (2009)
 Bridging Award, American Gastroenterological Association (2008-2009)
 Member, Board of Editors, Journal of Epithelial Biology & Pharmacology (Oak Park, IL) (2008-present)
 Member, Board of Editors, World Journal of Gastroenterology (Beijing, China) (2008-present)
 Junior Faculty Award, American Association of Immunologist (2006)
 Grant reviewer, The Eli and Edythe L. Broad Foundation (Los Angeles, CA), (2003-present)
 NIH, Mentored Clinical Scientist Development Award (2003-2008)
Current Research
 Intestinal epithelial cell biology
 Cellular and molecular biology of mucosal immunity
 Innate and acquired immune responses
 Chitin and chitinase in inflammatory bowel disease
 Colitis-associated carcinogenesis
 Disease-associated DNA methylation in intestinal tissues
Background
Dr. Emiko Mizoguchi graduated from Kurume University School of Medicine (Fukuoka, Japan) and obtained her M.D. and
Ph.D. degrees from the same University. She joined Dr. Atul K. Bhan’s laboratory in the Department of Pathology at
Massachusetts General Hospital (MGH) as a research fellow in 1992 and moved to the Department of Medicine in the
Gastrointestinal Unit at MGH under the mentorship of Dr. Daniel K. Podolsky as an Instructor of Medicine in 2003.
Currently, she is an Assistant Professor of Medicine at Harvard Medical School since 2006 and a Visiting, Associate
Professor at Kurume University School of Medicine since 2010. As a principal investigator of a basic research project
supported by NIH grants, she is investigating the pathogenesis of chronic colitis as well as colitis-associated cancer (CAC)
utilizing animal models.
Dr. Mizoguchi’s research interests are centered around the basic cellular and molecular mechanisms involved in the
functional modulation of colonic epithelial cells (CECs) during the development of inflammatory bowel disease (IBD). She
is one of the pioneers of animal models of IBD since she and her colleagues established the T cell receptor α knockout mouse
as an ulcerative colitis model in 1993.
She is currently focuses on studying the functional role of the chitinase 3-like 1 (CHI3L1) molecule in the colonic mocosa.
The CHI3L1 was upregulated after pro-inflammatory cytokine stimulation and enhanced the adhesion and internalization of
intracellular bacteria in CECs. Her present study provides a novel insight into the physiological role of mammalian
chitinases in host/microbial interactions. She is expanding the study of CHI3L1 to include other members of mammalian
chitinases (e.g., AMCase, chitotriosidase) in IBD and CAC. Her studies will provide a huge advance in understanding the
mechanism of IBD and CAC development and will provide a positive impact in diagnostic, therapeutic and prophylactic
approaches in these disorders.
Dr. Mizoguchi has served as an ad hoc reviewer in more than 30 scientific journals and an editorial board member in 7 peerreviewed journals.
Selected Publications (from 81 original articles and 20 review articles)
1.
Nagatani K, Wang S, Llado V, Lau CW, Li Z, Mizoguchi A, Nagler CR, Shibata Y, Reinecker HC, Mora JR, Mizoguchi E.
Chitin-microparticles for the control of intestinal inflammation. Inflammatory Bowel Diseases, in press.
2.
Kawada M, Seno H, Kanda K, Nakanishi Y, Akitake R, Komekado H, Kawada K, Sakai Y, Mizoguchi E, Chiba T. Chitinase
3-like 1 promotes macrophage recruitment and angiogenesis for colorectal cancer development. Oncogene, 2012;31:3111-3123.
3.
Nishida A, Lau CW, Zhang M, Andoh A, Shi HN, Mizoguchi E, Mizoguchi A. A membrane-bound mucin Muc1 serves as a
negative feedback in colitis-associated Th17 responses. Gastroenterology, 2012;142:865-874.
4.
Chen CC, Pekow J, Llado V, Kanneganti M, Lau CW, Mizoguchi A, Mino-Kenudson M, Bissonnette M, Mizoguchi E.
Chitinase 3-like 1 (CHI3L1/YKL-40) expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.
Am J Pathol, 2011, 179:1494-1503.
5.
Mizoguchi A, Mizoguchi E. Animal models of IBD: linkage to human disease. Curr Opini Pharmacol, 2010;10:578-587.
6.
Matharu K, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM,
Bhan AK, Snapper SB, Murakami H, Reinecker HC, Mizoguchi A, Nagler CR. Toll-like receptor 4-mediated regulation of spontaneous
Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology 2009, 137:1380-1390.
7.
Mizoguchi E, Hachiya Y, Kawada M, Nagatani K, Ogawa A, ugimoto K, Mizoguchi A, Podolsky DK. TNF receptor type Idependent activation of innate responses to reduce intestinal damage-associated mortality. Gastroenterology 2008;134:470-480.
8.
Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A. IL-22
ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008;118:524-544.
9.
Mizoguchi E. Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic
epithelial cells. Gastroenterology 2006;130:398-411.
10.
Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper SB, Terhorst
C, Blumberg RS, Mizoguchi A. Induced reactivity of intestinal CD4+ T cells with an epithelial cell lectin, galectin-4, contributes to
exacerbation of intestinal inflammation. Immunity 2004;20:681-693.
11.
Mizoguchi E, Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky D, Mizoguchi A. Colonic epithelial functional
phenotype varies with type and phase of experimental colitis. Gastroenterology 2003;125:148-61.
12.
Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK. Role
of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation. Gastroenterology
2002;122:134-144.
13.
Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10
producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002;16:219-230.
14.
de Jong YP, Abadia-Molina AC, Satoskar AR, Clarke K, Rietdijk S, Faubion WA, Mizoguchi E, Metz CN, Al Sahli M, ten
Hove T, Keates AC, Lubetsky JB, Farrell RJ, Michetti P, van Deventer SJ, Lolis E, David JR, Bhan AK, Terhorst C. Development of
chronic colitis is dependent on the cytokine MIF. Nature Immunol 2001;2:1061-1066.
15.
Hollander GA, Zuklys S, Morel C, Mizoguchi E , Mobbison K Simpson S, Terhorst C, Golan DE, Bhan AK, Burakoff SJ.
Monoalleic Expression of the interleukin-2 locus. Science 1998;279:2118-2121.
16.
Mizoguchi E, Mizoguchi A, Chiba C, Niles JL, Bhan AK. Anti-neutrophil cytoplasmic antibodies producing B cells in TCR a
- mutant mice with chronic colitis. Gastroenterology 1997;113:1828-1835.
17.
Mizoguchi A, Mizoguchi E , Smith RN, Preffer FI, Bhan AK. Suppressive role of B cells in chronic colitis of T cell receptor a
mutant mice. J Exp Med 1997;186:1749-1756.
18.
Mizoguchi E, Mizoguchi A, Bhan AK. Role of cytokines in the early stages of chronic colitis in TCR a -mutant mice. Lab
Invest 1997;76:385-397.
19.
Mizoguchi A, Mizoguchi E , Chiba C, Bhan AK: Role of appendix in the development of inflammatory bowel disease in
TCR- a mutant mice. J Exp Med 1996;184:707-715.
20.
Mombaert P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S: Spontaneous development of inflammatory
bowel disease in T cell receptor mutant mice. Cell 1993;75:275-282.