Structural Biology & Bio-Informatics Division
Dr. Sujoy Mukherjee
Ramanujan Fellow (2011 - )
Postdoctoral Fellow (2008 – 2011) – The Ohio State University
PhD (2008) – University of Illinois, Urbana-Champaign in Biophysics
& Computational Biology
B-Tech (2003) – I.I.T. Kharagpur in Biotechnology & Biochemical
Engineering.
Contact:
E-mail:
(preferred); sujoy AT csiriicb DOT in
Phone: +9133-24995715
Personal homepage: https://sites.google.com/site/mukherjeelab/
Current Research Interest
The overall goal of this lab is to apply solution and solid-state Nuclear Magnetic Resonance (NMR)
spectroscopy to probe the structure and dynamics of proteins undergoing conversion to amyloid
fibrils as well as membrane proteins. Some of the ongoing as well as recently initiated research
topics include:  Solution NMR studies of pre-amyloidogenic states of proteins along the aggregation
pathway.
 Investigating the structure and dynamics of amyloid fibrils using solid-state NMR.
 Structural studies of membrane proteins using solid-state NMR.
Positions Available:
Students from any branch of science and engineering with NET (CSIR/UGC) are welcome to apply
by sending email mukherjee.lab AT gmail DOT com. Fellows having an interest in quantitative line
of research, including the use of computational tools, are especially encouraged to apply. For
further details, please visit group website.
One (1) position is open for a research assistant to perform postdoctoral research in NMR.
Candidates with previous experience in solution or solid-state NMR are encouraged to apply.
List of important Publications:
8. Mukherjee, S.; Pondaven, S. P.; Jaroniec, C. P., Conformational Flexibility of a Human
Immunoglobulin Light Chain Variable Domain by Relaxation Dispersion Nuclear Magnetic
Resonance Spectroscopy: Implications for Protein Misfolding and Amyloid Assembly
Biochemistry 2011, 50, 5845-5857.
7. Jedidi, I.; Zhang, F.; Qiu, H.; Stahl, S. J.; Palmer, I.; Kaufman, J. D.; Nadaud, P. S.; Mukherjee,
S.; Wingfield, P. T.; Jaroniec, C. P.; Hinnebusch, A. G., Activator Gcn4 employs multiple segments
of Med15/Gal11, including the KIX domain, to recruit Mediator to target genes in vivo. J. Biol.
Chem. 2010, 285, (4), 2438-2455.
 Cover article and paper of the week
6. Mukherjee, S.; Pondaven, S.; Jaroniec, C., Backbone and side-chain 1H, 13C and 15N
resonance assignments for the κIV light-chain, variable domain of a recombinant, human
immunoglobulin κIV light-chain variable domain. Biomol. NMR Assign. 2009, 3, (2), 255-259.
5. Mukherjee, S.; Huang, C.; Guerra, F.; Wang, K.; Oldfield, E., Thermodynamics of
Bisphosphonates Binding to Human Bone: A Two-Site Model. J. Am. Chem. Soc. 2009, 131, (24),
8374-8375.
4. Zhang, Y.; Cao, R.; Yin, F.; Hudock, M.P.; Wang, H.; Guo, R.T.; Krysiak, K.; Mukherjee, S.;
Gao, Y.; Robinson, H.; Song, Y.; No, J.H.; Bergan, K.; Leon, A.; Cass, L.; Goddard, A.; Chang,
T.K.; Lin, F.Y.; Van Beek, E.V.; Papapoulos, S.; Wang, A.H.J.; Kubo, T.; Ochi, M.; Morita, C.T.;
Oldfield, E., Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase
Inhibitors: An X-ray and NMR Investigation. J. Am. Chem. Soc. 2009, 131, (14), 5153–516. This
article has been favorably reviewed in several news reports, including the following : New Anti-cancer Drug: 200 Times More Active In Killing Tumor Cells." Science Daily 26
March 2009. 3 April 2009
(http://www.sciencedaily.com/releases/2009/03/090325132458.htm)
 Better Bisphosphonates: Lipophilic compound kills more cancer than traditional analog.”
Chemical and Engineering news, Medicinal Chemistry, April 6, 2009
(http://pubs.acs.org/cen/news/87/i14/8714notw8.html)
 New drug agent knocks out multiple enzymes in cancer pathway” Internet Chemie,
(http://www.internetchemie.info/news/2009/mar09/bisphosphonates.html)
 New drug 200 times more active against tumour cells” IANS, 26 March, 2009
(http://www.thaindian.com/newsportal/sci-tech/new-drug-200-times-more-active-againsttumour-cells_100171451.html)
3. Mukherjee, S.; Song, Y.; Oldfield, E., NMR Investigations of the Static and Dynamic Structures
of Bisphosphonates on Bone: a Molecular Model. J. Am. Chem. Soc. 2008, 130, (4), 1264-1273.
2. Mao, J. H.; Mukherjee, S.; Zhang, Y.; Cao, R.; Sanders, J. M.; Song, Y. C.; Zhang, Y. H.;
Meints, G. A.; Gao, Y. G.; Mukkamala, D.; Hudock, M. P.; Oldfield, E., Solid-state NMR,
crystallographic, and computational investigation of Bisphosphonates and farnesyl diphosphate
synthase-bisphosphonate complexes. J. Am. Chem. Soc. 2006, 128, (45), 14485-1449.
1. Zhang, Y.; Mukherjee, S.; Oldfield, E., Zn-67 NMR chemical shifts and electric field gradients in
zinc complexes: A quantum chemical investigation. J. Am. Chem. Soc. 2005, 127, (8), 2370-2371