各位老师，以下是个人简介模板，请按照自己的情况填写中文、英文两个版本，请填写近五
年的成果获奖。
姓名 张丽男 副教授
姓名：张丽男
职务：在河北科技大学任副教授；在 Journal of Biophysics and Structural Biology (JBSB) 杂志
任编辑；并在《医药前沿》杂志担任特约编委。
医学博士
河北科技大学化学与制药工程学院药学系
Email：linan_0519@126.com
Tel: 0311- 81668391；18630155533
教育背景：
•1999～2004：河北医科大学，临床学院，临床，本科
•2004～2007：河北医科大学，基础课教学部，生理学，硕士
•2007～2010：河北医科大学，基础医学院，药理学，博士
工作经历：
•2010～至今 ：河北科技大学化学与制药工程学院
开设课程：
《生理药理学》
、
《药学英语》
研究方向：
神经系统谷氨酸兴奋毒性研究；Na+, K+-ATPase 信号通路研究
近五年科研、教学课题：
1)
国家自然基金（81402886）：一种新型肿瘤主动靶向治疗载体---P-糖蛋白高表达的间充
质干细胞的研究，2015-2017，主持人。
2)
河北省自然基金（H2012208080）：Na+,K+-ATPase 参与老年性痴呆模型小鼠学习记忆
的调节及其机制探讨，2012-2014，主持人。
3)
河北省教育厅青年基金项目（QN2014093）：钠钾泵参与白藜芦醇防护谷氨酸兴奋毒性
的机制探讨，2014-2016，主持人。
4)
国家自然基金课题（81200886）：CAPON 在脑缺血中的作用及其分子机制研究，
2013—2015，排名第二位。
5)
国家重大专项课题（2014ZX09507001）：新释药系统关键技术及新产品产业化研究，
2014-2016，排名第三位。
6)
校企合作项目（河北天成药业）：复方二甲双胍，2013.11~2014.11，主持人。
7)
《专业英语教学过程中的问题及相应对策》
，2011-2013，河北科技大学化学与制药工程学
院二期教学研究立项，主持人。
近五年发表的论文及著作：
（1）
Zhang LN, Sun YJ, Wang LX, Gao ZB*. Glutamate transporters/Na+, K+-ATPase, a
potential regulatory target of glutamate uptake. Molecular Neurobiology. 2015, Jan 14,
Epub ahead of print. SCI Impact Factor: 5.286
（2） Zhang LN, Sun YJ, Pan S, Li JX, Qu YE, Li Y, Wang YL, Gao ZB*. Na+-K+-ATPase, a
potent neuroprotective modulator against Alzheimer disease. Fundamental & Clinical
Pharmacology, 2013, 27: 96-103. SCI Impact Factor: 2.08
（3） Zhang LN, Li JX, Hao L, Sun YJ, Xie YH, Wu SM, Liu L, Chen XL, Gao ZB*.
Crosstalk between dopamine receptors and the Na+/K+‑ATPase. Molecular medicine
reports, 2013, 5: 1291. SCI Impact Factor: 1.484
（4） Zhang LN, Hao L, Wang HY, Su HN, Gao ZB*. The neuroprotective effect of resveratrol
against glutamate-Induced Excitotoxicity. Advances in Clinical and Experimental
Medicine. 2015, 24 (1): 161-165. SCI Impact Factor: 0.333
（5） Linan Zhang, et al. Serotonin-mediated modulation of Na+/K+ pump current in rat
hippocampal CA1 neurons. BMC Neuroscience. 2012, 13: 10.
（6） Linan Zhang, et al. Na+, K+-ATPase inhibition up-regulates NMDA-evoked currents in
rat hippocampal CA1 pyramidal neurons. Fundamental & Clinical Pharmacology. 2012,
26 (4): 503-512.
（7） Linan Zhang, et al. The Paradox of dopamine and angiotensin II-mediated Na+,
K+-ATPase regulation in renal proximal tubules. Clinical and Experimental Hypertension.
2010, 32(7): 464-468.
（8） Zibin Gao, Linan Zhang, Yongjun Sun. Nanotechnology applied to overcome tumor
drug resistance. J Control Release. 2012, 162 (1): 45–55.
（9） Gao ZB*, Zhang LN, Hu J, Sun YJ. Mesenchymal stem cells: a potential targeteddelivery
vehicle
for
anti-cancer
drug
loaded
nanoparticles.
Nanomedicine:
Nanotechnology, Biology, and Medicine, 2013, 9(2): 174-184. SCI Impact Factor:
6.202
（10） Huicai Guo, Fang Guo, Linan Zhang, et al. Enhancement of Na/K pump activity by
chronic intermittent hypobaric hypoxia protected against reperfusion injury. American
Journal of Physiology - Heart and Circulatory Physiology. 2011, 300 (6):H 2280-H2287.
（11） Zhe Zhang, Huicai Guo, Linan Zhang, et al. Isoform-specific regulation of the Na+/K+
pump by adenosine in guinea pig ventricular myocytes. Acta Pharmacol Sin. 2009, 30 (4):
404–412.
（12） Huicai Guo, Zhe Zhang, Linan Zhang, et al. Chronic intermittent hypobaric hypoxia
protects the heart against ischemic/ reperfusion injury through upregulation of antioxidant
enzymes in adult guinea pigs. Acta Pharmacologica Sinica. 2009, 30 (7): 947-955.
（13） Chen Xiong, Junxia Li, Huicai Guo, Linan Zhang, et al. The H1-H2 domain of the α1
isoform of Na+-K+-ATPase is involved in ouabain toxicity in rat ventricular myocytes.
Toxicology and Applied Pharmacology, 2012, 262: 32-42.
（14） Xiaoying Cao, Jianning Geng, Suwen Su, Linan Zhang, et al. Doxorubicin-loaded Zein
in situ gel for interstitial chemotherapy. Chemical & pharmaceutical bulletin., 2012, 60
(10): 1227-1233.
（15） Dai T, Yang E, Sun Y, Zhang L, Zhang L, Shen N, Li S, Liu L, Xie Y, Wu S, Gao Z*.
Preparation and drug release mechanism of CTS-TAX-NP-MSCs drug delivery system.
International Journal of Pharmaceutics. 2013, 456(1): 186–194. SCI Impact Factor:
3.785
（16） Zhao M, Hu J, Zhang L, Zhang L, Sun Y, Ma N, Chen X, Gao Z*. Study of amphotericin
B magnetic liposomes for brain targeting. International journal of pharmaceutics. 475
(1-2): 9-16. 2014 SCI Impact Factor: 3.785
（17） Li S, Hu J, Zhang LN, Zhang L, Sun YJ, Xie YH, Wu SM, Liu L, Gao ZB*. In-vitro and
in-vivo evaluation of austocystin D liposomes. Journal of Pharmacy and Pharmacology.
2013, 65 (3): 355-362, SCI Impact Factor: 2.161
（18） Ning Shen, Jie Hu, Yongjun Sun, Yinghua Xie, Shaomei Wu, Linan Zhang, Zibin Gao*.
Doxorubicin-loaded Zein in situ gel for interstitial chemotherapy of colorectal cancer.
Acta Pharmaceutica Sinica B. 2(6): 610-614, 2012
（19） 赵梦玉，张丽男，孙勇军，谢英花，吴韶梅，陈小龙，高子彬*. 两性霉素 B 磁性
脂质体的制备及磁靶向性研究，华西药学杂志，2014, 29(6): 618-621. 中文核心
（20） 李硕，张丽男，申宁，哈婧，尚振华，孙勇军，杨恩芸，刘磊，张赫明，高子彬*. 伊
潘立酮片的制备. 中国新药杂志, 2013, 22 (4): 402-407.中文核心
（21） 杨恩芸，王晓君，戴甜，张丽男，孙勇军，高子彬*. 壳聚糖修饰的紫杉醇纳米粒的
制备，华西药学杂志，2014,03:237-240. 中文核心
（22） 王晓君，杨恩芸，戴甜，张丽男，孙勇军，高子彬*. 阿莫西林油混悬液的工艺改进，
黑龙江畜牧兽医，2014,01:154-156. 中文核心
（23） 高子彬*，陈小龙，张丽男，王晓君，齐献利，谷艳玲. 离心造粒法制备醋氯芬酸微
丸. 河北科技大学学报，2015，36（1）
：30-35.
（24） 郭会彩, 张丽男, 张哲, 等. 间歇性低压低氧预处理对缺血/再灌注豚鼠心肌的保护
作用及对Na+, K+-ATPase 的影响. 中国老年学杂志, 2009, 29 (4): 388-391.
（25） 刘倩, 郭会彩, 张丽男, 等. Na+, K+-ATP 酶参与大鼠皮层神经元NMDA电流的调节.
中国药理学通报,2011,27(1):117-121.
（26） 石晓路, 柳絮, 郭会彩, 张丽男, 等. 大鼠心肌细胞分离方法的改进. 药理学通报,
2010, 26 (5): 687-690.
（27） 勾向博, 石晓路, 郭会彩, 柳絮, 张丽男, 苏倩, 王永利. 多柔比星对大鼠心肌Na+
-K+ 泵活性及α亚基的影响. 中国药学杂志, 2011 46 (4): 274-277.
（28） 张丽男, 高子彬，姚军，吴韶梅，哈婧，戎欣玉，于奕峰. 药学专业英语教学过程中
的问题及相应对策. 医药前沿, 2011, 1 (20): 207-208.
（29） 张丽男, 高子彬，孙勇军，谢英花，戎欣玉. 提高药学专业生理学教学质量的探讨. 卫
生职业教育, 2012, 12: 50-51.
（30） 孙勇军，张丽男，高子彬*. 药学高等教育与医药产业的共同发展. 产业与科技论坛,
2014, 13 (23): 16-17.
英文版
Linan Zhang M.D.
Name：Linan Zhang
Concurrent Academic Posts：Hebei University of Science and Technology, associate professor;
Journal of Biophysics and Structural Biology (JBSB), Editor;
Yi Yao Qian Yan, Special Editiorial Committee Member
Medical Doctor
Pharmacy Department, College of Chemical and Pharmaceutical Engineering, Hebei University of
Science and Technology
Email：linan_0519@126.com
Tel: 0311- 81668391,18630155533
Education background：
•1999～2004：Hebei Medical University, Clinical Medical School, Major: clinical medicine,
Bachelor Degree
•2004～2007：Hebei Medical University, Basic Courses Teaching Department, Major: physiology,
Master Degree
•2007～2010：Hebei Medical University, Basic Medicine College, Major: pharmacology,
Doctor Degree
Experience：
•2010～2015：Pharmacy Department, College of Chemical and Pharmaceutical Engineering,
Hebei University of Science and Technology
Courses：
《Physiology and Pharmacology》
、
《pharmaceutical English》
Research interest：
Glutamate exitotoxicity research；Na+, K+-ATPase signal transduction pathway
Research Projects：
1、Study of a promising tumor-targeting vehicle-mesenchymal stem cells highly expressing
P-glycoprotein, The Natural Science Foundation Committee , 2015-2017, No：81402886，Topic
manager
2. 《The modulation of Na+,K+-ATPase involving in learning and memory of senile dementia mice
and its underlying mechanism》，2012 project approval，The Natural Science Foundation
Committee of Hebei Provience，No：H2012208080，Topic manager.
3. Na+,K+-ATPase involving in resveratrol-induced protect against glutamate exitotoxicity.
2014-2016, No：QN2014093, Topic manager.
4、
《The effect of CAPON on cerebral ischemia and its mechanism》
，2013 project approval，
National Natural Science Foundation of China，No：81200886，The second person in charge.
5、《The problems and strategies of special English teaching course》
，2011 project approval，
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and
Technology，Topic manager.
Academic Achievement：
SCI articles：
1、 Zhang LN, Sun YJ, Wang LX, Gao ZB*. Glutamate transporters/Na+, K+-ATPase, a
potential regulatory target of glutamate uptake. Molecular Neurobiology. 2015, Jan 14, Epub
ahead of print. SCI Impact Factor: 5.286
2、 Zhang LN, Sun YJ, Pan S, Li JX, Qu YE, Li Y, Wang YL, Gao ZB*. Na+-K+-ATPase, a
potent neuroprotective modulator against Alzheimer disease. Fundamental & Clinical
Pharmacology, 2013, 27: 96-103. SCI Impact Factor: 2.08
3、 Zhang LN, Li JX, Hao L, Sun YJ, Xie YH, Wu SM, Liu L, Chen XL, Gao ZB*. Crosstalk
between dopamine receptors and the Na+/K+‑ATPase. Molecular medicine reports, 2013, 5:
1291. SCI Impact Factor: 1.484
4、 Zhang LN, Hao L, Wang HY, Su HN, Gao ZB*. The neuroprotective effect of resveratrol
against glutamate-Induced Excitotoxicity. Advances in Clinical and Experimental Medicine.
2015, 24 (1): 161-165. SCI Impact Factor: 0.333
5、 Linan Zhang, et al. Serotonin-mediated modulation of Na+/K+ pump current in rat
hippocampal CA1 neurons. BMC Neuroscience. 2012, 13: 10.
6、 Linan Zhang, et al. Na+, K+-ATPase inhibition up-regulates NMDA-evoked currents in rat
hippocampal CA1 pyramidal neurons. Fundamental & Clinical Pharmacology. 2012, 26 (4):
503-512.
7、 Linan Zhang, et al. The Paradox of dopamine and angiotensin II-mediated Na+, K+-ATPase
regulation in renal proximal tubules. Clinical and Experimental Hypertension. 2010, 32(7):
464-468.
8、 Zibin Gao, Linan Zhang, Yongjun Sun. Nanotechnology applied to overcome tumor drug
resistance. J Control Release. 2012, 162 (1): 45–55.
9、 Gao ZB*, Zhang LN, Hu J, Sun YJ. Mesenchymal stem cells: a potential targeted- delivery
vehicle for anti-cancer drug loaded nanoparticles. Nanomedicine: Nanotechnology, Biology,
and Medicine, 2013, 9(2): 174-184. SCI Impact Factor: 6.202
10、
Huicai Guo, Fang Guo, Linan Zhang, et al. Enhancement of Na/K pump activity by
chronic intermittent hypobaric hypoxia protected against reperfusion injury. American
Journal of Physiology - Heart and Circulatory Physiology. 2011, 300 (6):H 2280-H2287.
11、
Zhe Zhang, Huicai Guo, Linan Zhang, et al. Isoform-specific regulation of the Na+/K+
pump by adenosine in guinea pig ventricular myocytes. Acta Pharmacol Sin. 2009, 30 (4):
404–412.
12、
Huicai Guo, Zhe Zhang, Linan Zhang, et al. Chronic intermittent hypobaric hypoxia
protects the heart against ischemic/ reperfusion injury through upregulation of antioxidant
enzymes in adult guinea pigs. Acta Pharmacologica Sinica. 2009, 30 (7): 947-955.
13、
Chen Xiong, Junxia Li, Huicai Guo, Linan Zhang, et al. The H1-H2 domain of the α1
isoform of Na+-K+-ATPase is involved in ouabain toxicity in rat ventricular myocytes.
Toxicology and Applied Pharmacology, 2012, 262: 32-42.
14、
Xiaoying Cao, Jianning Geng, Suwen Su, Linan Zhang, et al. Doxorubicin-loaded Zein
in situ gel for interstitial chemotherapy. Chemical & pharmaceutical bulletin., 2012, 60 (10):
1227-1233.
15、
Dai T, Yang E, Sun Y, Zhang L, Zhang L, Shen N, Li S, Liu L, Xie Y, Wu S, Gao Z*.
Preparation and drug release mechanism of CTS-TAX-NP-MSCs drug delivery system.
International Journal of Pharmaceutics. 2013, 456(1): 186–194. SCI Impact Factor: 3.785
16、
Zhao M, Hu J, Zhang L, Zhang L, Sun Y, Ma N, Chen X, Gao Z*. Study of
amphotericin B magnetic liposomes for brain targeting. International journal of
pharmaceutics. 475 (1-2): 9-16. 2014 SCI Impact Factor: 3.785
17、
Li S, Hu J, Zhang LN, Zhang L, Sun YJ, Xie YH, Wu SM, Liu L, Gao ZB*. In-vitro
and in-vivo evaluation of austocystin D liposomes. Journal of Pharmacy and Pharmacology.
2013, 65 (3): 355-362, SCI Impact Factor: 2.161
Chinese articles：
18、
Shuo Li, Linan Zhang, et al. Preparation of iloperidone tablets. Chinese Journal of New
Drugs, 2013, 22 (4): 402-407.
19、
Huicai Guo, Linan Zhang, et al. Protective effect of CIHH against ischemia/
reperfusion injury in guinea pig heart. Chinese Journal of Gerontology, 2009, 29(4): 388-391
20、
Qian
Liu,
Huicai
Guo,
Linan
Zhang,
et
al.
Comprehensive
study
of
N-methyl-D-aspartate current involving Na+,K+-ATPase in rat cortical neuron. Chinese
Pharmacological Bulletin; 2011, 27 (1): 117-121.
21、
Xiaolu Shi, Xu Liu, Huicai Guo, Linan Zhang, et al. An improved method of isolation
of rat cardiac myocytes. Chinese Pharmacological Bulletin; 2010, 26 (5): 687-690.
22、
Xiangbo Gou, Xiaolu Shi, Huicai Guo, Xu Liu, Linan Zhang, et al. Activity of
Na+/K+-Pump Current and α Subunits Expression in Left Ventricles in Heart Failure Rats. Chin
Pharm J, 2011 46 (4): 274-277.
23、
Linan Zhang, et al. The problems and strategies of special English teaching course. Yi
Yao Qian Yan, 2011, 1 (20): 207-208.
24、
Linan Zhang, et al. Discussion about how to improve teaching quality of physiology.
Health Vocational Education, 2012, 12: 50-51.