Role of Haptoglobin Polymorphism in Chronic Kidney Disease in Taiwan
Presenter: Yi-Chun Chen
Adviser:
Prof. Hsien-Bin Huang
Date:
Apr 23, 2010
Abstract
Background: Chronic kidney disease (CKD) is increasingly recognized as a global
public health problem. The results regarding the association between haptoglobin (Hp)
polymorphism and nephropathy remain conflicting among different ethnic population.
The aim of this study was to evaluate the relationship between Hp polymorphism and
CKD in Taiwan.
Methods: From December 2008 through September 2009, a total of 401 subjects
were enrolled, including 205 subjects with CKD and 196 healthy controls. 3 major
Hp genotypes were analysed using polymerase chain reaction and electrophoresis.
The associated risk factors for advanced CKD were identified by multiple logistic
regression analysis with adjustments for demographic and comorbid conditions.
Linear-by-linear association chi-square test was performed to examine whether a
trend existed between 3 Hp genotypes and advanced CKD.
Results: There was no significant difference in the distribution of Hp genotypes and
allele frequency in subjects with CKD and controls. The prevalence of advanced
CKD (p = 0.04) and increased uric acid level (p = 0.04) was higher in subjects with
Hp 1-1 or 2-1 than those with Hp 2-2. Multiple logistic regression analysis showed
Hp 1-1 or 2-1 genotypes (OR, 0.487) and anemia (OR, 9.208) were significantly
independent risk factors for advanced CKD. The prevalence of advanced CKD was
significantly in order Hp 1-1 > Hp 2-1 > Hp 2-1 genotypes (p = 0.023).
Conclusions: The present study show that the Hp genotype does not predispose to
the occurrence of CKD; however, the Hp genotype is associated with advanced CKD.