Courses (First and second Semester 1428/ 1429) PHG 361: Vitamins, Minerals and Hormones (: Pharmacognosy 3) Definitions, classification , importance and functions as well as the disorders which occur due to excess or deficiency of Vitamins, Minerals and Hormones as well as the chemistry of vitamins and hormones as well as their SAR will be discussed. Minerals: Are classified to: a- Macro-elements b- Micro-elements Vitamins: Are classified to: a- Fat soluble Vitamins b- Water soluble Vitamins Hormones may be classified according to: a- Site of production b- Chemical nature References: 1- www.netdoctor.co.uk/health_advice/facts/vitamins_which.htm 2- www.nlm.nih.gov/medlineplus/vitamins.html 3- www.nlm.nih.gov/medlineplus/vitamins.html 4- www.liferesearchuniversal.com/minerals.html 5- en.wikipedia.org/wiki/Steroid_hormone topics.nytimes.com/.../health/diseasesconditionsandhealthtopics/hormones/index.html?inline =nyt-classifier. 7. G. Litwack & A.W. Norman: Hormones. 1997 Academic Press (1997). PHG 461: Pharmacognosy 4 The course deals with the study of antibiotics, naturally occurring antineoplastic agents. The origin, structure and structure activity relationship, mechanism of action, spectrum and uses, adverse effect and drug interaction of each antibiotic will be discussed. The following questions concerning antineoplastic agents will be answered: What is cancer, mechanism of cancer formation, different types of cancer, warning signs of cancer, factors which increase risk of cancer, general consideration in antineoplastic therapy as well as treatment of cancer. Antibiotics areclassified to: a-B-lactam b- Aminoglycosides c- Tetracyclines d- Macrolides e- Antifungal agents f- Polypeptides g- Misc.group i- CAF ii- Antituberculous agents iii- Various structure References: 1-Antibiotic and Chemotherapy. H.P.Lambert & F.W. O'Grady.Churchill Livingstone (1992) 2- The Antimicrobial Drugs . Scholar, E.M.& Pratt, W.b.Oxford University press (2000) 3-Drug Information Handbook .B. Beatrice et al (2000) 4- www.Healthlinks.washington.edu. 5- http://www.wikipedia.org. 6- http://www. Drugs.com. PHG 474: Screening, Separation and Analysis of Plant Constituents The course covers the methods and techniques employed for screening medicinal plants for their bioactive constituents. Discussed are also recent developments regarding methods of extraction, isolation, purification and spectroscopic identification of plant bioactive constituents . Applications of chromatographic and spectroscopic techniques in the analysis of the isolated compounds. References: 1-Plant Drug Analysis. Wagner, H., Bladt, S. & Zgainski. E.M. American Botanical Council (1995) 2- Pharmacognosy. Trease & Evans. W.B.Saunders Company (1996) 3- www.uok.edu.pk/faculties/pharmacognosy/details.php 4- www.springerlink.com/index/p70l236363g66262.pdf 5- ull.chemistry.uakron.edu/analytical/Chromatography/ PHG 455: Biotechnology and tissue culture Cell biology, Protein synthesis, different techniques of biotechnology including r-DNA, Monoclonal antibodies production, Polymerase chain reaction and Gene therapy. The microbial models as well as metabolism studies will be discussed. References: 1-Pharmaceutical Biotechnology. Crommelin, J.A.J. & Sindelar, R.D. Gordon & Breach Publishing Group (1998)