張凱誌副教授
Research background
 Microbiology and molecular biology of Helicobacter pylori
Special techniques
 The techniques of phage expression library, transposon mutagenesis and DNA microarrays
are currently used.
 Molecular diagnosis and typing of microorganisms.
Research Interests
 Molecular pathogenesis of Helicobacter pylori
 Molecular epidemiology of Helicobacter pylori
Publications
 Chang, K. C., Ho, S. W., Yang, J, C., Wang, J. T. (1997) Isolation of a genetic locus
associated with metronidazole resistance in Helicobacter pylori. Biochemical Biophysical
Research Communications. 236: 785-788. (SCI)
 Chang, C. S., Chen, L. T., Yang, J. C., Lin, J. T., Chang, K. C., Wang, J. T. (1999) Isolation
of a Helicobacter pylori protein, FldA, associated with mucosa-associated lymphoid tissue
lymphoma of the stomach. Gastroenterology. 118(5): 988-91. (SCI)
 Chang, K. C., Yeh, Y. C., Lin, T. L., and Wang, J. T. (2001) Identification of genes
associated with natural competence in Helicobacter pylori by Transposon shuttle random
mutagenesis. Biochemical Biophysical Research Communications. 288: 961-968. (SCI)
 Yeh, Y. C., Chang, K. C., Yang, J. C., Fang, C. T., and Wang, J. T. (2002) Association of
Metronidazole Resistance and Natural Competence in Helicobacter pylori. Antimicrobial
Agents and Chemotherapy. 46 (5): 1564-1567. (SCI)
 Yeh, Y. C., Lin, T. Z., Chang, K. C., and Wang, J. T. (2003) Characterization of a comE3
homologue essential for DNA transformation in Helicobacter pylori. Infection and Immunity.
71 (9): 5427-5431. (SCI)
 Lin, T. Z., Sun, C. T., Chang, K. C., Wang, J. T. (2004) Isolation and characterization of a
HpyC1I restriction-modification system in Helicobacter pylori. Journal of Biological
Chemistry. 279 (12): 11156-11162. (SCI)
 Lin, T. Z., Sun, C. T., Chang, K. C., Wang, J. T. (2006) Isolation and characterization of a
competence operon associated with transformation and adhesion in Helicobacter pylori.
Microbes and Infection.8(12): 2756-2765. (SCI)
 Soo PC, Horng YT, Chang KC, Wang JY, Hsueh PR, Chuang CY, Lu CC, Lai HC.(2009) A
simple gold nanoparticle probes assay for identification of Mycobacterium tuberculosis and
Mycobacterium tuberculosis complex from clinical specimens. Mol Cell Probes.
Oct;23(5):240-6.
 Horng YT, Chang KC, Chien CC, Wei YH, Sun YM, Soo PC.(2009) Enhanced
polyhydroxybutyrate (PHB) production via the coexpressed phaCAB and vgb genes
controlled by arabinose P promoter in Escherichia coli. Lett Appl Microbiol. 2010
Feb;50(2):158-67.
 Kae-Maw Wang, Yu-Hsien Liu, Teng-Yi Lin, Ding-Guo Liu, Po-Chi Soo, Wei-Tung Hung,
Kai-Chih Chang*.(2009) Prevalence of Enterobius Vermicularis Infection among
Elementary School Children in Hualien, Taiwan. J Biomed Lab Sci.21(4):132-136
 Horng YT, Chang KC, Chien CC, Wei YH, Sun YM, Soo PC.(2010) Enhanced
polyhydroxybutyrate (PHB) production via the coexpressed phaCAB and vgb genes
controlled by arabinose P promoter in Escherichia coli. Lett Appl Microbiol.
Feb;50(2):158-67.
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Yu-Tze Horng, Kai-Chih Chang, Yen-Ni Liu, Hsin-Chih Lai, Po-Chi Soo.(2010) The
RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic,
prodigiosin, in Serratia marcescens. International Journal of Medical Microbiology.30(5):
304-312.
Ting-Mi Tsai, Hsin-Hou Chang, Kai-Chih Chang, Yu-Lin Liu, Chun-Chieh Tseng.(2010) A
comparative study of the bactericidal effect of photocatalytic oxidation by TiO2 on
antibiotic-resistant and antibiotic-sensitive bacteria. Journal of Chemical Technology &
Biotechnology Volume 85(12):1642–1653.
Kai-Chih Chang, Ming-Feng Lin, Nien-Tsung Lin, Wen-Jui Wu, Han-Yueh Kuo, Teng-Yi
Lin, Tsai-Lian Yang, Yu-Chuan Chen, Ming-Li Liou.(2010) Clonal spread of tigecycline and
rifampicin-resistant, multidrug-resistant Acinetobacter baumannii in eastern Taiwan. Journal
of Microbiology, Immunology and Infection (Accepted).
Ming-Feng Lin, Kai-Chih Chang, Chang-Yao Yang, Chih-Man Yang, Chih-Chuan Xiao,
Han-Yeh Kuo, and Ming-Li Liou.(2010) Role of integrons in antimicrobial susceptibility
patterns of Acinetobacter baumannii. Japanese Journal of Infectious Diseases
63(6):440–443.
Nien-Tsung Lin, Pei-Yu Chiou, Kai-Chih Chang, Li-Kuang Chen, Meng-Jiun Lai.(2010)
Isolation and characterization of
Research in Microbiology Volume 161(5):308-314.
Kai-Chih Chang, Nien-Tsung Lin, Anren Hu, Yu-Shan Lin, Li-Kuang Chen and Meng-Jiun
-like virus infecting
multidrug-resistant Acinetobacter baumannii. Genomics Publish online: January 2011.
Meng-Jiun Lai, Nien-Tsung Lin, Anren Hu, Po-Chi Soo, Li-Kuang Chen, Long-Hui Chen
and Kai-Chih Chang*.(2011) Antibacterial activity of Acinetobacter baumannii phage
-positive and Gram-negative bacteria.
Applied Microbiology and Biotechnology Publish online: 25 January 2011.
Kuo, HanYueh、Chang, kai-chih、Kuo JW、Yueh HW、Liou ML*.(2012) Imipenem: a potent
multidrug-resistance inducer in Acinetobacter baumannii. International Journal of
Antimicrobial Agents,39:33-38.
Chang, KC、Lin, MF、Lin, NT、Wu, WJ、Kuo, HY、Lin, TY、Yang, TL、Chen, YC、
Liou, ML. (2012) Clonal spread of multidrug-resistant Acinetobacter baumannii in eastern
Taiwan. Journal of Microbiology, Immunology and Infection,45:37-42.
Pao-Kuei Hsiao、Wan-Ting Chen、Kai-Chih Chang、Yu-Ju Ke、Chung-Long Kuo、
Chun-Chieh Tseng*. (2012) Performance of CHROMagar Staph aureus and CHROMagar
MRSA for Detection of Airborne Methicillin-Resistant and Methicillin-Sensitive
Staphylococcus aureus. Aerosol Science and Technology,46:297-308.
Ming-Li Liou、Chih-Chin Liu、Chia-Wei Lu,、Ming-Feng Hsieh、Kai-Chih Chang、Han-Yueh
Kuo、Chi-Ching Lee、Chun-Tien Chang、Cheng-Yao Yang、Chuan Yi Tang. (2012) Genome
Sequence of Acinetobacter baumannii TYTH-1. Journal of Bacteriology,194:6974-6974.