SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. SEARCH STRATEGY Pubmed Search phrase: ("Child Abuse"[Mesh] or "Child Abuse, Sexual"[Mesh] or sexual abuse [title/abstract] or physical abuse [title/abstract] or emotional abuse [title/abstract]) AND ("Anorexia"[Mesh] or "Anorexia Nervosa"[Mesh] or "Binge-Eating Disorder"[Mesh] or "Eating Disorders"[Mesh] or "Bulimia"[Mesh] or "Bulimia Nervosa"[Mesh]) Generated items: 395 Embase Search phrase: ('child abuse'/exp OR 'child sexual abuse'/exp) AND ('anorexia'/exp OR 'anorexia nervosa'/exp OR 'bulimia'/exp OR 'binge eating disorder'/exp OR 'eating disorders'/exp) Generated items: 402 PsycInfo (via ProQuest) Search phrase: (SU.EXACT("Child Abuse") OR AB("Child Abuse") OR AB("Sexual Abuse") OR AB ("Physical Abuse") OR AB("Emotional Abuse")) AND (SU.EXACT("Bulimia") OR SU.EXACT("Anorexia Nervosa") OR SU.EXACT("Eating Disorders") OR SU.EXACT("Binge Eating") OR SU.EXACT("Binge Eating Disorder") OR AB("Anorexia") OR AB("Bulimia") OR AB("Binge Eating") OR AB("Eating Disorder*")) Generated items: 649 Pilots (via ProQuest) Search phrase: (SU.EXACT("Child Abuse") OR AB("Child Abuse") OR AB("Sexual Abuse") OR AB ("Physical Abuse") OR AB("Emotional Abuse")) AND (SU.EXACT("Bulimia") OR SU.EXACT("Anorexia Nervosa") OR SU.EXACT("Eating Disorders") OR SU.EXACT("Binge Eating") OR SU.EXACT("Binge Eating Disorder") OR AB("Anorexia") OR AB("Bulimia") OR AB("Binge Eating") OR AB("Eating Disorder*")) Generated items: 268 SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. Table S1. Characteristics of studies included in the Meta-Analysis. Study Country Setting Subjects Mean age index group (IG)/control group (CG) % of females in index and control groups Abramson and Lucido, 1991 California, USA 16 BN, 47 controls 34.18 / 23,0 Allison et al., 2007 Pennsylvania, USA Undergraduate psychology classes, university-based bulimic support groups, an inpatient eating disorder program, and private practitioners working with EDs patients Participants recruited using broad media advertisements targeted people who thought had eating problems 176 BED, 57 NES (Night Eating Syndrome) 38 OC (Obese Comparison) Cachelin et al., 2005 California, USA Community sample of Mexican American women Favaro et al., 1998 Italy EDs Measure CA Measure Age of abuse 100 / 100 Bulimia Test (BULIT), DSM III criteria Sexual Events Questionnaire (SEQ) 12 years or younger 44.9 (9.1) / 39.6 (10.8) 79 / 63 Childhood Trauma Questionnaires (CTQ) Prior to age 18 4 AN, 26 BN, 29 BED, 21 EDNOS, 110 HC (Healthy Controls) 27.9 (range 18 to 45) / 24.6 (range 18 to 45) 0/0 Interview for Identifying Risk Factors for Eating Disorders (RFI, Version 2.0) Prior to age 18 Patients referred to two ED units (one in-patient and one out-patient unit) and female students 86 AN, 69 BN, 81 HC AN: 23.1 (5.6) (range 14 to 48); BN: 23.7 (5.1) (ranged 16 to 43) / 20.1 (0.6) 98 / 100 DSM-IV-TR criteria diagnoses, Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCIDI/P) and Eating Disorder Examination Interview (EDE) 12th ed. DSM-IV-TR criteria diagnoses, Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCIDI) and Eating Disorder Examination Interview (EDE) 12th ed. Semi-structured interview and DSM-IV criteria Semi-structured interview on sexual and/or physical abuse Prior to age 18 Semi-structured interview on sexual and/or physical abuse Life Events Prior to age 18 Favaro et al., 2003 Italy Women resided in two areas of the city of Padova 19AN, 43 BN, 102ED, 832HC Range 18 to 25 (entire sample) 100 / 100 Feldman and New York, USA Black, Latino gay, and 66 CSA, 127 not 33 (9) (entire 0/0 Eating Disorders Inventory (EDI) Clinical interviews using the ED Section of SCID-I; DSM IV criteria Computer- Prior to age 18 SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. Mayer, 2007 bisexual men sampled from community venues CSA; 64 CPA, 129 not CPA sample) Garfinkel et al., 1995 Ontario, Canada Subjects across Ontario 55 full syndrome BN, 4196 female control Under 65 (entire sample) 100 / 100 Grilo and Masheb, 2001 Connecticut, USA Consecutive outpatients, and HMO female normative sample 145 BED, 1125 adult women control 43.6 (8.6) / 42 76 / 100 Groleau et al., 2012 Jaite et al., 2012 Québec, Canada Germany Women recruited through a specialized EDs Program and normal eaters recruited with advertisements in newspapers and on university bulletin boards and websites 136 BN, 40 EDNOS, 139 normal eaters woman Patients recruited from the Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy and 50 ANR, 27 ANBP, 44 HC 24.95 (5.52) / 23.91 (5.62) 100 / 100 assisted personal interview version 19 of the World Health Organization’s Composite International Diagnostic Interview (WMHCIDI DSM-IV) Structured interview University of Michigan - CIDI with specific questions added for BN and DSMIII criteria DSM-IV-TR criteria diagnoses, SCID-I, Questionnaire on Eating and Weight Patterns Revised Eating Disorder Questionnaire (EDE-Q) DSM-IV criteria diagnosis and EDE interview Questionnaire (LQE) and interview about event narrative Interview Questions about family background Childhood Childhood Trauma Questionnaire (CTQ) Prior to age 18 Childhood Trauma Interview (CTI) Childhood Childhood Trauma Questionnaire (CTQ) Prior to age 18 Eating Attitudes Test-26 (EAT-26) AN-R 15.8 (1.6); NBP 16.1 (1.1) / 15.7 (1.3) 100 / 100 Ineffectiveness and Perfectionism subscales of the Eating Disorder Inventory-2 (EDI2) DSM-IV criteria diagnosis and Structured Inventory for Anorexic and Bulimic SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. Kern and Hastings, 1995 Nevada, USA control recruited from several high schools Undergraduate woman Korte et al., 1998 Illinois, USA Psychology students Laporte and Gutman, 2001 Québec, Canada Leonard et al., 2003 Québec, Canada Mangweth et al., 1996 Austria Massachusetts, USA Outpatient sample recruited trough their therapist and public advertisement; control group recruited with public advertisement 30 BN and 50 HC extracted among 719 normal eaters Almost 22 (6.8) (entire sample) 100 / 100 37 BN and 326 HC 20 (Range 18-44) (entire sample) 76 / 53 35 BPD, 34 AN, 33 HC AN 23,5 (7) / 23,4 (7) 100 / 100 Outpatient sample recruited at a specialized EDs program service; control group recruited at universities course and through public advertisements Female students with ”uncontrollable eating binges” and control students who had “received ankle or knee surgery” at universities 51 BN, 25 normal eaters 23.18 (5.87) / 24.71 (6.52) 100 / 100 S1: 33 Austrian BN and 33 controls S1: 22 (2.2) S1: 100 / 100 S2: 20 (2.0) S2: 100 / 100 S2: 33 American BN and 33 controls Syndromes (SIAB-EX) BULIT-R and DSM-III criteria BULIT-R and DSM-IV criteria Eating Disorder Module of the Structured Clinical Interview for DSM III (SCID-I) Eating Attitude Test (EAT) EDE Interview, DSM IV criteria, and EAT-26 Child Sexual Abuse Questionnaire (CSA) Trauma symptom Checklist 40 Modified Finkelhor Questionnaire Questions on verbal abuse, physical hurt o sexual abuse Prior to age 16 Prior to age 16 Prior to age 16 Chidhood Trauma Interview (CTI) Prior to age 14 DSM-III-R criteria diagnosis, Structured Clinical Interview for DSM-III-R (SCIDI) Interview covering childhood experiences Childhood Miller et al., 1993 Kansas, USA Women enrolled at introductory psychology at university 72 BN and 72 controls The majority of the subjects were 18 and 19 100 / 100 Bulimic Investigatory Test, Edinburgh (BITE), DSM-III criteria for BN. Sexual Life Events Questionnaire (SLEQ) Prior to age 12 Nagata et al., 2001 Japan 38 ANR, 46 ANBP,76 BN and 99 controls. ANR 22.5 (6.3), ANBP 24.8 (4.7), BN (22.3 ± 4.3), controls 20.8 (2.5) 100 / 100 DSM-IV criteria and Eating Disorders Inventory (EDI) Physical and Sexual Abuse Questionnaire Prior to age 18 Olivardia et al., 1995 Massachusetts, USA Outpatients of the Department of Neuropsychiatry Osaka City University Hospital and female students attending a nursing school in Osaka. College student recruited with advertisement in 13 BN, 2 AN, 4 BN-AN, 6 BED and Range 18 to 25 (entire sample) 0 /0 Diagnostic Survey for Eating Interview based on the work of Childhood SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. school newspaper 25 control with Osgod Schlatter Romans et al., 2001 New Zealand Women were randomly selected from Otago, New Zealand, electoral rolls. 254 CSA 223 not CSA Not specified 100 / 100 Rorty et al., 1994 California, USA Woman recruited trough newspaper advertisement and referral from local care providers 40 BN, 40 recovered BN, 40 HC 24,61 (4,12) / 24,18 (4,33) 100 / 100 Sachs Ericsson et al., 2012 Florida, USA Steiger et al., 2001 Québec, Canada Steiger and Zanko, 1990 Québec, Canada Steiger et al., 2004 Québec, Canada National Comorbidity Survey-Replication. A subset of participants in the Part II survey completed a section on EDs. Woman recruited trough a specialized EDs clinic and trough university classes or newspaper advertisement Patients, hospital staff, patient’ friends, students Women recruited through a specialized eating disorder program for adults and trough university classes or newspaper advertisement Disorder Revised, DSM IV criteria, EAT, EDI, SCIDI/P Present State Examination (PSE) interview and additional ICD−10 eating disorders questions DSM IV criteria Version of the Schedule for Affective Disorders and Schizofrenia modified to EDs (EAT-SADS-L) Eating Disorder Questionnaire (EDQ) SCID-I/P DSM IV criteria, structured diagnostic interview WHOCIDI Finkelor Four items related to PA and SA Prior to age 15 Screening items for CSA during the PSE interview Prior to age 16 SAEQ Sexual Abuse Exposure Questionnaire (SAEQ) Prior to age 17 Maternal and Paternal psychological Abuse (PSY) 137 BED, 2823 controls 40.1 (18) / 45.2 (14.7) 57.7 / 42.3 34 BN, 24 controls 23,95 (4,25) / 24,60 (7,28) 100 / 100 DSM IV criteria, EDE EAT Chidlhood Trauma Interview (CTI) Prior to age 14 16 ANR, 12ANB, 20 B/AN - (Bulimic with an AN history), 25 B/O (BN with no prior AN), 24 controls, 21 psychiatric controls 73 BN and 50 HC ANR 25,82 (6,69), ANB 31,42 (7,96), B/AN 24,25 (4,74), B/O 25,60 (5,32) / NC 28,04 (5,93) 100 / 100 DSM III criteria Childhood sexual traumata questionnaire Childhood and adolescence 26,15 (5,30) / 22,82 (5,11) 100 / 100 DSM IV criteria, EDE EAT26 EDI2 Childhood Trauma Interview (CTI) Prior to age 14 SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. Steiger et al., 2012 Québec, Canada Women recruited through a specialized eating disorder program for adults and using public and university/collegebased announcements Women from the community white American or black American 174 BN and 130 control 25.95 (6.36) / 24.79 (6.34) 100 / 100 DSM-IV criteria EDE Childhood Trauma Interview (CTI) Prior to age 18 Striegel-Moore et al., 2002 Connecticut, USA S1: 102 BED, 164 HC. S2: 86 BED, 86 HC. 30.5 (5.8) / matched to BED age (within 2 years) 100 / 100 DSM IV criteria, SCID-I EDE Interview Prior to age 18 Stuart et al., 1990 South Carolina, USA Woman who sought treatment in a psychiatric department 30 BN, 15 subjects with depressive illness, 100 control 30 / 37 100 / 100 DSM-III-R criteria Childhood Environment Questionnaire Childhood Vize and Cooper, 1995 UK Patient referred to an Eating Disorder Service and students, secretaries, shop assistant AN 25 (5.1), BN 24,5 (5.1) / 21,6 (3,5) 100 / 100 DSM-III-R criteria EDE Childhood Experience of Care and Abuse Measure Interview (CECA) Prior to age 17 Webster and Palmer, 2000 UK AN 29, BN 30, mixed AN/BN 30 / controls 34 100 / 100 DSM-III-R criteria CECA (PA) Sexual Life Events Inventory (SLEI) (SA) Prior to age 17 Welch and Fairburn, 1996 UK Woman, inpatients or outpatients, in contact with an Eating Disorder Service and from general medical practice from two different surgeries Women registered with 23 general practices located in both urban and rural areas 40 AN, 60 BN, 40 subject with major Depressive disorder (DD), and 40 controls. A purified subsample with 28 AN, 48 BN, 35 MDD, 30 controls 32 BN, 28 AN, 20 mixed AN/BN, 40 DD, 40 controls 102 BN, 102 controls with other psychiatric disorders, 204 HC BN 23.7 (4.9) / matched with the case for age 100 / 100 DSM-III-R criteria, EDE, EDE Q Childhood Wentz et al., 2005 Sweden A population cohort 51 AN and 51 controls 16 / 16 94 / 94 Wonderlich et al., 2001 North Dakota, USA Women recruited from clinical centres specializing in trauma related and advertisements in local newspapers 26 CSA, 21 RAPE, 25 CSA+RAPE, 25 controls CSA 38 (8,3) CSA+RAPE 42,8 (5,8) / 37,6 (9,1) 100 / 100 DSM-IV and DSM-III-R criteria MorganRussell assessment schedule EDE One section of the interview concerned with history of CSA, CPA SLE According CSA definition reported pag. 403 Prior to age 18 Prior to age 18 SUPPLEMENTAL DIGITAL CONTENT, Caslini et al. Figure S1. Funnel Plot for the Association Between Child Sexual Abuse and Anorexia Nervosa.