Biology 3404 Genetics
MWF 1:00-1:50, Tues 12:30-2:30
Spring 2006
Syllabus
Instructor - Dr. Donna Janes (office telephone 486-1241 ; home phone 963-9744; office in 227
Beto Hall; office hours:, other hours by appointment); email address
donna.janes@concordia.edu
Text- Introduction to Genetic Analysis,7th edition. Author: Griffiths.
Laboratory Manual- Genetics Laboratory Investigations, 12th edition. Author: Mertens.
Homepage- http://faculty.concordia.edu/janes/
Course Objectives-Students will understand the basic concepts and terminology of genetics, including the
following:
- Basic patterns of chromosomal heredity
- Chromosomal linkage and mapping
- Cellular regulation of transcription and translation, as well as post translational control
mechanisms
- Microbial genetics as applied to DNA technology in industry and the fields of forensics and
medicine
- Chromosomal mutations and their relationship to inherited diseases and cancer
- Basic Population genetics
- How basic gene expression is controlled during the cell cycle and during development
- New technologies that are advancing the field, such as proteomics, the genome project, and
DNA chip analysis.
-Students will be able to search the scientific literature in this field, and apply the knowledge to a
set of practical problems. They will also be able to apply this knowledge across other fields
of biology.
-Students will be able to do a genetic cross of an organism and analyze the data
-Will be able to read and interpret current genetic scientific literature
Evaluation –
Hourly Exams- 3 X 100 points……………………..…300 points
Final Exam- 1 X 200 points…………………..……200 points
Lab write-ups- 3 multi period * labs X 75………….. 225 points
Lab write-ups - 3 single period labs X 25…….………..75 points
Homework……6 X 33.3…………………… ……….200 points
Total Points:……………………………………………1000
900 > A
800-900 = B
700-800 =C
600-700 =D
Less than 600 points is a failing grade
Academic Integrity - : I operate under the assumption that all students are trustworthy. A
violation of the trust which I have placed in you such as cheating on an exam or
quiz, submitting work that is not your own, or plagiarizing the work of someone
else is taken very seriously. You may certainly discuss aspects of the class with
your fellow students but the work that you turn in must be your own. On the first
offense, the penalty will be a 0 grade on that assignment plus the automatic
lowering of the course grade by one letter after final tabulations are completed. The
second breach of honesty will result in a failing grade in the course and referral to
the Vice-President of Student Services to be handled according to the policy in the
Student Handbook
Assignment Schedule
Date
Week 1
1/18
1/20
Week 2
1/23
1/24
1/25
1/27
Topic
----------------------------------------------Overview of transcription/translation
Mendelian genetics- autosomal
-----------------------------------------------Mendelian genetics- autosomal/sex
linked
Lab: Monohybrid cross
Chromosome organization & structure
Organelle chromosomes
Week 3
1/30
1/31
2/1
2/3
Week 4
2/6
-----------------------------------------------Chromosomal linkage (eukaryotic)
Lab: Monohybrid cross
Linkage analysis (Chi-square tests)
Chromosomal mapping (eukaryotic)
----------------------------------------------Mapping problems
2/7
2/8
2/10
Lab: Monohybrid Cross
Week 5
EXAM #1
Mendelian genetics and Linkage
Mapping
-----------------------------------------------
Reading
Assignments/Tests
Chapter 1
Chapter 2
Chapter 2
Lab #1
Chapter 3
Chapter 3
Chapter 4
Lab#1
Chapter 4
Chapter 4
Chapter 4
Lab#1
1A
Homework #1 due
Chapter 2: Problems
2, 7, 15, 21, 27, 29,
40
1B
Homework #2 due
Chapter 4: Problems
2, 5, 6, 10a&b, 14, 20
a&b
1C
EXAM #1
2/13
2/14
2/15
2/17
Bacteriophage genetics
Lab: Monohybrid cross completion
Phage mapping
Plasmid mapping in class problems
Chapter 5
Lab 1
Chapter 5
Chapter 5
Week 6
2/20
2/21
--------------------------------------------Review of DNA replication
Lab: Transformation
Chapter 7
Lab 18
2/22
2/24
Week 7
2/27
2/28
3/1
3/3
Transcription
Translation
----------------------------------------------Transcriptional regulation
Lab: Gene Regulation
Transcriptional regulation
Transcriptional regulation
Week 8
3/6
-----------------------------------------------EXAM #2
Microbial genetics, Regulation of :DNA
replication, transcription, translation
Lab: plasmid DNA harvest and
restriction digestion
Recombinant DNA technology
Recombinant DNA technology
March 13th-March 17th Spring Break
3/7
3/8
3/10
S.B.
week
Week 10
3/20
3/21
3/22
3/24
Week 11
3/27
3/28
-------------------------------------------Genomics
Lab: gel electrophoresis
Mutations-Occurrence and Induction
1D
Turn in Monohybrid
cross report*
2A
Homework Chapter
5 Problems: 17, 26
a&b&c, + take home
problem
Chapter 8
Chapter 9
Chapter 10
Lab 19
Chapter 10
Chapter 10
2B
Homework Chapter
10 Problems: 2, 4, 5,
6
EXAM #2-
Lab 15, 16
3A
Chapter 11
Chapter 11
Chapter 12
Lab 16
Chapter 14
------------------------------------------------Mutation repair mechanisms
Chapter 14
Lab: Bacterial Mutagenesis
Lab 21
3/29
Mutation repair mechanisms
Chapter 14
3/31
Mutations-cancer
Chapter 17
3B
4
Turn in lab on DNA
harvest, digestion,
and electrophoresis
Homework Chapter
14 Problems: 1,2, 8,
11, 16, 17
Week 12
4/3
4/4
-----------------------------------------------Chromosomal Mutations-Structural
Lab: Human Chromosomes
4/5
4/7
Week 13
4/10
Chromosomal Mutations- Aneuploidy
Transposable elements
-----------------------------------------------Recombination
Chapter 15
Chapter 13
4/11
Lab: Scientific Literature
Note: An essay question will appear
on the exam from this paper
EXAM #3
Technology and Mutations
Easter Break
---------------------------------------------Easter Break
Lab: Fingerprint Analysis
TBA
Population genetics
Field Day
---------------------------------------------Population genetics
Lab: Population Genetics: The
Hardy Weinberg Principle
Quantitative Genetics
Quantitative Genetics
Chapter 19
4/12
4/14
Week 14
4/17
4/18
4/19
4/21
Week 15
4/24
4/25
4/26
4/28
Week 16
5/1
5/2
5/3
5/5
---------------------------------------------Genetic Basis of Development
Lab: Scientific Literature
Note: A question will appear on the
final from this paper
Genetic Basis of Development
Final Exam Review
Monday May 8th, 12:30-2:30
Chapter 15
Lab 11
Chapter 14
5
Turn in report on
Mutagenesis*
Turn in report on
Human
Chromosomes
EXAM # 3
Lab 23
Chapter 19
Lab 24
Pg 237-242
Chapter 20
Chapter 20
Chapter 18
TBA
6
Turn in report on
Fingerprint analysis
7
Homework Chapter
19 problems: 1, 2, 10
Turn in report on
population genetics
Chapter 18
Final Exam