Pedigree Project 1. Pick a genetic disease that we have discussed. Pick a letter to represent alleles. 2. Create an imaginary pedigree, at least 4 generations; each couple has 2 children always and only. 3. The original couple are both heterozygous. Exceptions- Huntington’s’ and Taysachs 4. Use a coin to decide the genotype for each of the spouses throughout your pedigree. H-heads, T-tails HH-homozygous dominant, TT- homozygous recessive, HT- heterozygous 5. Create a punnett's square beside each couple to show the possible genotypes of their offspring. 6. Use a coin to decide the genotype of their children. 7. Label the genotype of each individual, list both if two are possible. 8. Fill in the shapes of affected individuals, and half fill all carrier individuals. 9. Use roman numerals to number each generation and then number each individual in the generation. 10. List the following information somewhere on your pedigree. 1. Who are the heterozygous individuals? 2. Who are the homozygous dominant individuals? 3. How many people in your pedigree have your disease? Who are they? 4. Using the rules above, could it have been possible to create a pedigree with no homozygous recessive individuals? 11.Use the information on your disease in the book to write a description of your disease and put it on or attached to your pedigree. What are the major differences between a normal individual and an affected individual? You should include at least 2 graphics, printed or drawn. 12.Write a fictional description for your pedigree. You may be as creative as you want, but you must assign names, give a brief backstory for each couple including how they met, and include a description of how the disease has affected the family. Do affected individuals die early, live normal lives, require special treatments, etc. 13.If you do a 3 minute presentation on your disease and pedigree you can earn 5 bonus points. 14.THIS PROJECT IS WORTH A TEST GRADE! CATEGORY 4 Required Elements The project includes all required elements as well as additional information. Use of Class Time Used time well during each class period. Focused on getting the project done. Never distracted others. 3 All required elements are included on the project. Used time well during each class period. Usually focused on getting the project done and never distracted others. 2 All but 1 of the required elements are included on the project. 1 Several required elements were missing. Used some of the Did not use class time well during time to focus on the each class period. project OR often There was some distracted others. focus on getting the project done but occasionally distracted others. Graphics All graphics are All graphics are All graphics relate Graphics do not Relevance related to the topic related to the topic to the topic. Most relate to the topic and make it easier and most make it graphics have an OR several graphics to understand. All easier to explanation. have no graphics have an understand. All explanation. explanation. graphics have an explanation. Content - Accuracy All required Most required Hals or less of Less than 25% of content is accurate content is accurate required content is required content is and displayed on and displayed on accurate and accurate and the project. the project. displayed on the displayed on the project. project. Knowledge Gained Student can Student can Student can Student appears to accurately answer accurately answer accurately answer have insufficient all questions most questions about 75% of knowledge about related to facts in related to facts in questions related to the facts or the poster and the poster and facts in the poster processes used in processes used to processes used to and processes used the project. create the project. create the project. to create the project. Attractiveness The project is The project is The project is The project is exceptionally attractive in terms acceptably distractingly messy attractive in terms of design, layout attractive though it or very poorly of design, layout, and neatness. may be a bit messy. designed. It is not and neatness. attractive.