Figure S1: Trends in age standardised hysterectomy rates by region of birth in NSW women, 19732008. Modelled and empirical rates using hysterectomy-corrected populations as
denominators.
UK & Ireland
New Zealand
Europe
Middle East & North Africa
Asia
2
6
2
6
2
6
Australia
1975 1980 1985 1990 1995 2000 2005
2
6
Rest of the world
1975 1980 1985 1990 1995 2000 2005
Year
Modelled
Empirical
Figure S2- Trends in age-adjusted cervical cancer incidence and mortality by broad age categories
in NSW women, 1973-2008
(APC1: annual percent change from 1973-1991, APC2: annual percent change from 1991-2008)
Fig S2a All ages
APC2=-4.67 (-5.12, -4.23)
APC2=-4.97 (-5.41, -4.53)
2
5
10
20
40
1
Original 2 incidence: APC1=-2.28 (-2.66, -1.91)
Corrected incidence: APC1=-2.51 (-2.88, -2.13)
0
1
APC2=-4.62 (-5.24, -4.00)
APC2=-4.91 (-5.52, -4.29)
Original 2 mortality: APC1=-2.94 (-3.46, -2.43)
Corrected mortality: APC1=-3.13 (-3.64, -2.62)
1980
1975
1985
1995
1990
2000
2005
Year
2
1
Corrected
Incidence (fitted): Original
2
1
Corrected
Mortality (fitted): Original
Tests of APC1=APC2:
1
1
P(original 2 incidence)<0.0001, P(original2 mortality)=0.0011
P(corrected incidence)<0.0001, P(corrected mortality)=0.0005
1
Original results shown in Figure 1a in the manuscript repeated here for convenience. 2Corrected results derived
using the same models to generate Figure 1a in the manuscript but using hysterectomy-corrected populations at
risk.
Fig S2b ≤49 years of age
1
APC2=-4.79 (-5.48, -4.09)
APC2=-5.01 (-5.70, -4.32)
2
5
10 20 40
Original 2 incidence: APC1=-2.15 (-2.73, -1.57)
Corrected incidence: APC1=-2.40 (-2.98, -1.82)
0
1
Original 2 mortality: APC1=-1.26 (-2.46, -0.05)
Corrected mortality: APC1=-1.56 (-2.75, -0.36)
1975
1980
1985
APC2=-6.16 (-7.58, -4.72)
APC2=-6.43 (-7.84, -5.00)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)<0.0001,
P(original2 mortality)<0.0001
P(corrected incidence)<0.0001, P(corrected mortality)<0.0001
1
Original
results shown in Figure 1b in the manuscript repeated here for convenience. 2Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
Fig S2a 50-69 years of age
1
APC2=-4.92 (-5.72, -4.11)
APC2=-5.38 (-6.17, -4.58)
2
5
10 20 40
Original 2 incidence: APC1=-2.85 (-3.50, -2.20)
Corrected incidence: APC1=-3.15 (-3.80, -2.51)
0
1
Original 2 mortality: APC1=-4.03 (-4.90, -3.15)
Corrected mortality: APC1=-4.31 (-5.17, -3.43)
1975
1980
1985
APC2=-4.11 (-5.23, -2.99)
APC2=-4.57 (-5.67, -3.44)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Corrected
1
Tests of APC1=APC2:
1
P(original 2 incidence)=0.0018, P(original2 mortality)=0.92
P(corrected incidence)=0.0007, P(corrected mortality)=0.78
1
Original
results shown in Figure 1c in the manuscript repeated here for convenience. 2Corrected results derived using the
same models to generate Figure 1c in the manuscript but using hysterectomy-corrected populations at risk.
Fig S2b 70+ years of age
1
APC2=-4.12 (-5.16, -3.07)
APC2=-4.28 (-5.31, -3.24)
2
5
10 20 40
Original 2 incidence: APC1=-1.26 (-2.26, -0.26)
Corrected incidence: APC1=-1.23 (-2.22, -0.24)
0
1
Original 2 mortality: APC1=-2.74 (-3.75, -1.72)
Corrected mortality: APC1=-2.70 (-3.71, -1.69)
1975
1980
1985
APC2=-4.21 (-5.34, -3.07)
APC2=-4.35 (-5.47, -3.22)
1990
1995
2000
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)=0.0020, P(original2 mortality)=0.13
P(corrected incidence)=0.0009, P(corrected mortality)=0.090
2005
1
Original results shown in Figure 1d in the manuscript repeated here for convenience. 2Corrected results derived
using the same models to generate Figure 1d in the manuscript but using hysterectomy-corrected populations at risk.
Figure S3- Trends in age-corrected cervical cancer incidence and mortality in all ages by region of
birth in NSW women, 1973-2008
(APC1: annual percent change from 1973-1991, APC2: annual percent change from 1991-2008)
Fig S3a Australia
APC2=-4.81 (-5.34, -4.27)
APC2=-5.11 (-5.64, -4.57)
2
5
10
20
40
1
Original 2 incidence: APC1=-2.25 (-2.68, -1.81)
Corrected incidence: APC1=-2.46 (-2.89, -2.02)
0
1
Original 2 mortality: APC1=-2.80 (-3.39, -2.20)
Corrected mortality: APC1=-2.96 (-3.56, -2.36)
1975
1980
1985
APC2=-4.64 (-5.37, -3.90)
APC2=-4.93 (-5.66, -4.19)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)<0.0001, P(original2 mortality)=0.0024
P(corrected incidence)<0.0001, P(corrected mortality)=0.0011
1
Original
results shown in Figure 2a in the manuscript repeated here for convenience. Corrected results derived using the
same models to generate Figure 2a in the manuscript but using hysterectomy-corrected populations at risk.
2
Fig S3b UK& Ireland
APC2=-4.14 (-5.68, -2.57)
APC2=-4.52 (-6.06, -2.96)
2
5
10 20
40
1
Original 2 incidence: APC1=-1.86 (-3.09, -0.61)
Corrected incidence: APC1=-2.18 (-3.40, -0.93)
0
1
Original 2 mortality: APC1=-2.28 (-3.87, -0.66)
Corrected mortality: APC1=-2.56 (-4.15, -0.94)
1975
1980
1985
APC2=-7.91 (-10.16, -5.60)
APC2=-8.24 (-10.48, -5.94)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
Corrected
1
1
P(original 2 incidence)=0.073, P(original2 mortality)=0.0014
P(corrected incidence)=0.064, P(corrected mortality)=0.0012
1
Original
results shown in Figure 1a in the manuscript repeated here for convenience. Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
2
Fig S3c New Zealand
APC2=-5.06 (-7.95, -2.08)
APC2=-5.45 (-8.32, -2.48)
2
5
10
20
40
1
Original 2 incidence: APC1=-1.60 (-4.58, 1.46)
Corrected incidence: APC1=-2.05 (-5.01, 1.01)
0
1
Original 2 mortality: APC1=-0.09 (-5.26, 5.37)
Corrected mortality: APC1=-0.57 (-5.72, 4.86)
1975
1980
1985
APC2=-4.42 (-9.15, 0.56)
APC2=-4.92 (-9.62, 0.03)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)=0.20, P(original2 mortality)=0.35
P(corrected incidence)=0.20, P(corrected mortality)=0.34
1
Original
results shown in Figure 1a in the manuscript repeated here for convenience. 2Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
Fig S3d Rest of Europe
APC2=-3.47 (-4.93, -1.99)
APC2=-3.80 (-5.25, -2.32)
2
5
10
20
40
1
Original 2 incidence: APC1=-3.40 (-4.57, -2.21)
Corrected incidence: APC1=-3.65 (-4.82, -2.47)
0
1
Original 2 mortality: APC1=-4.68 (-6.30, -3.03)
Corrected mortality: APC1=-4.94 (-6.55, -3.30)
1975
1980
1985
APC2=-3.30 (-5.22, -1.33)
APC2=-3.61 (-5.53, -1.66)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)=0.95, P(original2 mortality)=0.40
P(corrected incidence)=0.90, P(corrected mortality)=0.41
1
Original
results shown in Figure 1a in the manuscript repeated here for convenience. Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
2
Fig S3e Middle East and North Africa
APC2=-8.49 (-11.99, -4.85)
APC2=-8.60 (-12.09, -4.97)
2
5
10
20
40
1
Original 2 incidence: APC1=-2.36 (-5.72, 1.12)
Corrected incidence: APC1=-2.35 (-5.71, 1.13)
1
0
Original 2 mortality: APC1=0.34 (-6.52, 7.69)
Corrected mortality: APC1=0.42 (-6.43, 7.78)
1975
1980
1985
APC2=-2.99 (-8.06, 2.37)
APC2=-3.04 (-8.11, 2.30)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
Corrected
1
1
P(original 2 incidence)=0.050, P(original2 mortality)=0.55
P(corrected incidence)=0.045, P(corrected mortality)=0.53
1
Original
results shown in Figure 1a in the manuscript repeated here for convenience. 2Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
Fig S3f Asia
APC2=-6.39 (-7.91, -4.85)
APC2=-6.58 (-8.10, -5.04)
2
5
10
20
40
1
Original 2 incidence: APC1=-1.45 (-3.69, 0.84)
Corrected incidence: APC1=-1.45 (-3.69, 0.84)
0
1
Original 2 mortality: APC1=-0.85 (-5.04, 3.52)
Corrected mortality: APC1=-0.80 (-4.99, 3.57)
1975
1980
1985
APC2=-6.52 (-9.26, -3.71)
APC2=-6.68 (-9.41, -3.87)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)=0.0033, P(original2 mortality)=0.069
P(corrected incidence)=0.0023, P(corrected mortality)=0.059
1
Original
results shown in Figure 1a in the manuscript repeated here for convenience. Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
2
Fig S3g Rest of the world
APC2=-0.39 (-2.82, 2.11)
APC2=-0.65 (-3.08, 1.84)
2
5
10
20
40
1
Original 2 incidence: APC1=-2.45 (-5.48, 0.67)
Corrected incidence: APC1=-2.55 (-5.58, 0.57)
0
1
Original 2 mortality: APC1=-7.51 (-11.70, -3.13)
Corrected mortality: APC1=-7.59 (-11.77, -3.21)
1975
1980
1985
APC2=2.11 (-1.92, 6.31)
APC2=1.85 (-2.17, 6.03)
1990
1995
2000
2005
Year
1
2
Incidence (fitted): Original
Corrected
1
2
Mortality (fitted): Original
Tests of APC1=APC2:
1
Corrected
1
P(original 2 incidence)=0.41, P(original2 mortality)=0.013
P(corrected incidence)=0.45, P(corrected mortality)=0.015
1
Original
results shown in Figure 1a in the manuscript repeated here for convenience. Corrected results derived using the
same models to generate Figure 1b in the manuscript but using hysterectomy-corrected populations at risk.
2