UNIVERSITY OF MIAMI Curriculum Vitae Standard Format 1. Date: February 09, 2005 2. Name: Stephen P. Richman 4. Office Phone: (305) 243-4909 6. Current Academic Rank: Professor 7. Primary Department: Department of Medicine 8. Citizenship: U.S.A. 9. Visa Type (if non-citizen): N/A HIGHER EDUCATION 10. Institutional (institution; degree; date conferred): June 1961 - June 1963 Stanford University, Palo Alto, California June 1963 - June 1965 A.B. - Washington University, St. Louis, Missouri June 1965 - June 1969 M.D. - Case Western Reserve University, Cleveland, Ohio 11. Non-Institutional (description; dates): N/A 12. Certification, licensure (description; board or agency; dates): July 1970 National Board Medical Examiners July 1972 American Board of Internal Medicine October 1977 American Board of Internal Medicine - Medical Oncology 1 State Licenses June 1970 July 1974 July 1980 June 1985 Pennsylvania Texas Kentucky Florida EXPERIENCE 13. Academic (institutions; rank/status; dates): April 1999- July 2001 Acting Chief, Division of Hematology/Oncology July 1985 - Present Professor of Medicine, University of Miami School of Medicine June 1969 - July 1970 Intern, Hospital University of Pennsylvania, Philadelphia, Pennsylvania June 1970 - July 1972 Resident, Medicine, Hospital University of Pennsylvania, Philadelphia, Pennsylvania June 1972 - July 1974 Fellow in Oncology, Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas June 1974- July 1975 Faculty Associate, Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030. June 1975 - July 1980 Assistant Professor of Medicine, Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 June 1976 - July 1980 Assistant Professor of Medicine, Department of Medicine, The University of Texas Medical School at Houston June 1980 - July 1985 Associate Professor of Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky June 1980 - July 1985 Associate Professor of Pharmacology, University of Louisville, Louisville, Kentucky April 1983 Board of Trustees, Kentucky Chapter Leukemia Society of America, Inc. 1984 Principal Investigator, University of Louisville, Southeastern Cancer Study Group 2 June 1987- July 1992 Principal Investigator, University of Miami, Southwest Oncology Group June 1985- July 1991 Chief, Division of Medical Oncology, Sylvester Comprehensive Cancer Center April 1989 - July 1991 Acting Chairman, Dept. of Oncology March 1996- Present Associate Director for Networks and Managed Care, Sylvester Comprehensive Cancer Center July 2000 Chairperson, Committee AA@, University of Miami IRB. 14. Non-Academic (employers; title; responsibilities; dates): N/A 15. Military (branch; rank; responsibilities; dates): N/A PUBLICATIONS [author(s) (in actual precedence of authorship); title; publisher or journal name; date (current year first); page numbers] 16. Books and monographs published: N/A 17. Juried or refereed journal articles and exhibitions: 1. Richman, S.P., et al: Studies of Vicia faba root meristems irradiated with a negative pion beam. Rad. Res. Suppl. 7:283-289, l967. 2. Izumi, A.K. and Richman, S.P.: Ectopic adrenocorticotropic hormone syndrome. Arch. Dermatol. l02:555-559, l970. 3. Richman, S.P., Mavligit, G.M., Wolk, R., Gutterman, J.U. and Hersh, E.M.: Epilesional scarification: Preliminary report on a new approach to local immunotherapy. JAMA 234:1233-1235, l975. 4. Gercovich, F.G., Richman, S.P. Rodriguez, V., Luna, M., McCredie, K.B., and Brodey, G.P.: Successful control of systemic Aspergillus niger infections in two patients with acute leukemia. Cancer 36:2271-2276, l975. 5. Hersh, E.M., Gutterman, J.U., Mavligit, G.M., Reed, R.C., and Richman, S.P.: BCG vaccine and its derivatives. Potential practical considerations and precautions in human cancer immunotherapy. JAMA 235:646-650, l976. 6. Richman, S.P., Livingston, R.B., Gutterman, J.U., Suen, J.Y. and Chemotherapy versus chemoimmunotherapy of head and neck cancer: randomized study. Cancer Treat. Rep. 60:535-539, l976. 3 Hersh, E.M.: Report of a 7. Rodriguez, V., Richman, S.P., Benjamin, R.S., et al.: Phase II study with Baker's antifol in solid tumors. Cancer Res. 37:980-983, l977. 8. Richman, S.P., Gutterman, J.U., Hersh, E.M. and Mavligit, G. M.: Phase I study of immunotherapy with methanol extraction residue of BCG (MER). Cancer Treat. Repts. 6l:47l-471, l977 9. Schwarz, M.A., Gutterman, J.U., Hersh, E.M., Richman, S.P. and Mavligit, G.M.: Immunotherapy and chemoimmunotherapy of malignant disease with BCG and nonviable mycobacterial fractions. World J Surg. l:555-583, l977. 10. Suen, J.Y., Richman, S.P., Livingston, R.L., Hersh, E.M., Craig, R. and Tonymon, K.: Results of the BCG adjuvant immunotherapy in l00 patients with epidermoid carcinoma of the head and neck. Am. J. Surg. l34:474-478, l977. 11. Hortobagyi, G.N., Richman, S.P. Dandridge, K., Gutterman, J.U., Blumenschein, D.R. and Hersh, E.M.: Immunotherapy with BCG administration by scarification. Standardization of reactions and managements of side effects. Cancer 42:2293-2303, l978. 12. Hortobagyi, G.N., Gutterman, J.U., Snyder, R.O., Richman, S.P. and Hersh, E.M.: Pseudomonas vaccine: A phase I evaluation for cancer research. Cancer Immunology and Immunotherapy 4:20l-207, l978. 13. Richman, S.P., Gutterman, J.U., Hersh, E.M. and Ribi, E.E.: Phase I-II study of intratumor immunotherapy with BCG cell wall skeleton plus P3. Cancer Immunology and Immunotherapy 5:4l-44, l978. 14. Issell, B.F., Valdevieso, M., Hersh, E.M., Richman, S.P., Gutterman, J.U. and Bodey, G.P.: Combination chemoimmunotherapy for extensive non-oat cell lung cancer. Cancer Treat Rep. 62:1059-1063, l978. 15. Richman, S.P., Gutterman,J.U. and Hersh, E.M.: Cancer Immunotherapy. Canadian Medical Assoc. J. 120:322-329, l979. 16. Hortobagyi, G.N., Gutterman, J.U., Blumenschein, G.R., Tashima, C.K., Burgess, M.A., Einhorn, L., Buzdar, A.U., Richman, S.P. and Hersh, E.M.: Combination chemotherapy of metastatic breast cancer with 5-fluorouracil, Adriamycin and Cyclophosphamide, and BCG. Cancer 43:1225-1233, l979. 17. Blumenschein, G.R., Hortobagyi, G.N., Richman, S.P. et al: Alternating noncross resistant combination chemotherapy and active non-specific immunotherapy with BCG or MER-BCG for advanced breast carcinoma. Cancer 45:742-749, l980. 18. Maroun, J.A., Quesada, J., Hersh, E.M., Gutterman, J.U., Richman, S.P. et al.: A phase I toxicity study of methanol extraction residue (MER) of Bacillus Calmette Guerin by intervenous route. 4 Cancer Treat. Rep. 63:1781-1786, l979. 19. Richman, S.P., Gutterman, J.U. and Hersh, E.M.: Chemotherapy and Immunotherapy of malignant melanoma. Compreh. Ther. 6:57-6l, l980. 20. Richman, S., Chism, V.T. and Murphy, S.G.: Effect of microbial fractions and vehicle on the survival of mice beating the Lewis lung carcinoma. Cancer Treat. Rep. 64:13291333, l980. 21. Richman, S.P., Hersh, E.M., Gutterman, J.U., Rios, A., Hortobagyi, G.N., Blumenschein, G.R. and Rib, E.E.: Administration of BCG cell wall skeleton into malignant effusions. Toxic and therapeutic effects. Cancer Treat. Rep. 65:383-387, l98l. 22. Richman, S.P., Chism, V.T. and Murphy, S.G.: Augmentation of ADCC in mice by microbial fractions. Cancer Immunol. Immunother. 11:233-238, l981. 23. Valdivieso, M., Richman, S., Burgess, A.M. et al.: Initial clinical studies of vindesine. Cancer Treat. Rep. 65:873-875, l98l. 24. Feun, L.G., Jordan, G., Burgess, M.A., Hersh, E.M., Mavligit, G., McBride, C.M., Benjamin, R.S. and Richman, S.P., et al.: The Natural History of Resectable Metastatic Melanoma (Stage IVA Melanoma). Cancer 50:1656-1663, l982. 25. Blijham, G.H., Barlogie, B. and Richman, S. Et al: Medulloblastoma and neuroblastoma in adults. Neth. J. Med. 25 (4):94-99, l982. 26. Woodcock, T.M., Blumenreich, M.S., Richman, S.P. Kubota, T.T., Gentile, P.S. and Allegra, J.C.: Combination Chemotherapy with Cis-Diamminedichloroplatinum and Vinblastine in Advanced Non-Small Cell Lung Cancer. J. Clin. Oncol. l:247-250, l983. 27. Allegra, J.C., Woodcock, T.M., Richman, S.P., Bland, K.I. and Witliff, J.L.: A Phase II Trial of Tamoxifen, Premarin, Methotrexate and 5-Fluorouracil in Metastatic Breast Cancer. Breast Cancer Treat. and Res. 2:93-99, l982. 28. Richman, S.P., Woodcock, T. M., Kubota, T.T., Blumenreich, M.S., Gentile, P.S. and Allegra J.C.: A Phase II Trial of Vinblastine, Bleomycin and Cisplatin (VBP) Followed by Decarbazine and Mitolactol in Metastatic Melanoma. Cancer Treat. Repts. 68:l395-l396, l984. 29. Blumenreich, M.S., Woodcock, T.M., Jones, M., Richman, S.P. et al.: High dose cisdiamminedichloroplatinum II in patients with advanced malignancies. Cancer 55:1118-1122, 1985. 30. Blumenreich, M.S., Woodcock, T.M., Richman, S.P, et al.: A Phase I trial of Dactinomycin intravenous infusion in patients with advanced malignancies. Cancer 56:256-258, l985. 31. Blumenreich, M.S., Woodcock, T.M., Gentile, P.S., Barnes, G.R., Jose, B., Sherrill, E.J., Richman, 5 S.P., et al. High-Dose cisplatin and vinblastine infusion with or without radiation therapy in patients with advanced non-small cell lung cancer. J. Clin. Oncol. 5:l725-l730, l987. 32. Sridhar, K.S., Bounassi M.J., Raub, W., and Richman, S.P.: Clinical features of adenosquamous lung carcinoma in 127 patients. Am. Rev. Respir. Dis. 142:19-23, 1990. 33. Sridhar, K.S., Samy, T.S.A., Agarwal, R.P., Duncan, R.C., Benedetto, P., Krishan, A.G., Vogel, C.L., Feun, L.G., Savaraj,N.M., Richman,S.P. and Zubrod, C.G. A Phase I study of 4'-0-Tetrahydropyranyladriamycin. Cancer 66:2082-2091, 1990. 34. Feun, L.G., Savaraj, N., Benedetto, P., Hanlon, J., Sridhar, K.S., Collier, M., Richman, S., Liao, S.H., and Clendennin, N.J. Phase I trial of piritrexim capsules using prolonged, low-dose oral administration for the treatment of advanced malignancies. J.Natl. Cancer Inst. 83: 51-55, 1991. 35. Ardalan, B, Chua, L., Tian, E., Reddy, R., Sridhar, K.S., Benedetto, P., Richman, S. et al. A Phase II study of weekly 24 hour infusion with high-dose Fluorouracil with Leucovorin in colorectal carcinoma. J. Clin Oncol 9: 625-630, l99l. 36. Sridhar, K., Hussein, A., Benedetto, P., Waldman, S., Feun, L., Savaraj, N., and Richman S. Phase II Trial of Mitoxantrone in Head and Neck Carcinoma. Am. J. Clin. Oncol. 14:298-304, 1991. 37. Ardalan, B., Sridhar K.S., Benedetto, P., Richman, S., Waldman, S., Morrell, L., Feun, L., Savaraj, N., Fodor, M., Livingstone, A. A Phase I, II Study of High Dose 5-Fluorouracil and High Dose Leucovorin with Low Dose Phosphonacetyl-L-Aspartic Acid in Patients with Advanced Malignancies. Cancer 68:1242-1246, 1991. 38. Sridhar K.S., Raub, Jr., W., Duncan R.C., Hilsenbeck S., and Richman S.P. Lung carcinoma in 1,336 patients. Am. J. Clin. Oncol. 14:496-508, 1991. 39. Gucalp R, Ritch P, Wiernik PH, Sarma PR, Keller A, Richman SP, Tauer K, Neidhart J, Mallette LE, Siegel R and VandePol CJ. Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia. J. Clin. Oncol. 10:134-142, 1992. 40. Ardalan, B., Sridhar, K., Reddy, R., Benedetto, P., Richman, S., Waldman, S., Morrell, L., Feun, L., Savaraj, N., and Livingstone, A. Phase I study of high dose 5-fluorouracil and high dose leucovorin with low dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies. Int. J. Radiation Oncology Biol. Phys. 22: 511-514, 1992. 41. Ardalan B., Ucar A., Reddy R, Livingstone AS, Markoe A, Schwade J, Richman SP, Donofrio K. Phase I trial of low dose N-Phosphonacetyl-L-Aspartic Acid and High dose 5-Fluorouracil administered concomitantly with Radiation Therapy for Unresectable Localized Adenocarcinoma of the Pancreas. Cancer, 74:7, 1994. 42. Hantel, A., Tangen, C.M., Macdonald, J.S., Richman, S.P. et al. Phase II trial of 6 trimetrexate in untreated advanced gastric carcinoma. Invest. New Drug 12:155-157, 1994. 43. Feun L.G., Savaraj, N., Moffat, F., Robinson, D., Liebmann, A., Hurley J., Raub, Jr.,W.A. and Richman, S.P. Phase II trial of recombinant interferon-alpha with BCNU, cisplatin, DTIC, and tamoxifen in advanced malignant melanoma. Melanoma Res. 5: 273-276, 1995. 44. Whitehead R.P., Wolf, M.K., Solanski, D.L., Hemstreet, G.P., Benedetto, P., Richman, S.P. et al. A phase II trial of continuous infusion recombinant interleukin-2 in patients with advanced renal cell carcinoma: A Southwest Oncology Group Study. J. Immunotherapy 18: 104-114, 1995. 45. Martino, R.L., Fleming, T.R., Morrell, L.M., Ardalan,B., Richman, S.P., and Macdonald, J.S. Phase II trial of low dose N-(phosphonacetyl)-disodium-L-aspartic acid and high-dose 24-hour infusional 5-Fluorouracil in advanced gastric adenocarcinoma. A Southwest Oncology Group Study.Invest. New Drugs 14:419-421, 1996. 46. Morrell, L.E., Lee, Y.J., Hurley, J., Arias, M., Mies,C., Richman, S.P., Hernandez, H., Donofrio, K., Raub, Jr.,W.A., and Cassileth, P.A. A phase II trial of neoadjuvant methotrexate, vinblastine,doxorubicin, and cisplatinum in the treatment of patients with locally advanced breast carcinoma.Cancer 82:503-511, 1998. 47. Anderson, K.O. Mendoza, T.R., Valero, V., Richman, S.P., et al. Minority Cancer Patients and their Providers. Pain management attitudes and practice. Cancer 88:1929-1938, 2000. 48. Anderson, K.O., Richman,S.R., Hurley, J., et. al. Cancer pain management among minority patients: Perceived needs and barriers to optimal control. Submitted to cancer ABSTRACTS 1. Richman, S.P.: Phase I study of Immunotherapy with methanol extraction residue of BCG (MER). Proc. Amer. Soc. Clin. Oncol. l6:l025, l975. 2. Rodriguez, V., Richman, S. P., Benjamin, R.S. et al.: Amer. Assoc. Cancer Res. l7:60, l976. 3. Richman, S.P., Gutterman, J.U., Hersh, E.M. and Price, H.R.: Phase I study of intratumor immunotherapy with BCG cell wall skeleton plus P3. Proc. Amer. Soc. Clin. Oncol. l8:35l, l977. 4. Richman, S. P., Murphy, S., Hersh, E.M., Gutterman, J.U. and Ribi, E.: Toxicity in mice of BCG wall skeleton, trehalose dimycolate and mutant endotoxin attached to oil droplets. AFCR 26:36A, 1978. 5. Richman, S.P., Hortobagyi, G.N., Gutterman, J.U., Hersh, E.M., Mavligit, G. and Dale, S.: Toxicity of BCG administered by scarification to cancer patients. Am. Soc. Clin. Oncol. l9:449, l978. 7 Phase II studies of Baker's antifol. Proc. 6. Richman, S.P., Chism, V. and Murphy,S.: Vehicle and microbial fractions interact to prolong survival of mice with Lewis lung carcinoma. Amer. Assoc. Cancer Res. 20:l44, l979. 7. Murphy, S., Richman, S., and Hersh, E.: Immunological unresponsiveness in treated leukemic guinea pigs. Amer. Assoc. Cancer Res. 20:l70, l979. 8. Richman, S.P., Hortobagyi, G.N., Legha, S.S., et al.: Prognostic significance of pleural effusion patients with metastatic breast carcinoma treated with systemic chemotherapy. Proc. Amer. Assoc. Res. 2l:l70, l980. 9. Allegra, J.C., Woodcock, T.M., Richman, S.P., Patel, J.D. and Wittliff, J.L.: A Phase II Evaluation of Tamoxifen, Premarin, Methotrexate (MTX) and 5-Fluorouracil (5-FU) in Stage IV Breast Cancer. Am. Soc. Clin. Oncol. 22:44l, l980. 10. Woodcock, T.M., Allegra, J.C., Richman, S.P., Horowitz, J.A., and Snider, H.L.: A Phase II Evaluation of Vinblastine (VLB) and Diamminedichloroplatinum II (DDP) in Non-Small Cell Cancer of the Lung. Am. Soc. Clin. Oncol. 22:50l, l98l 11. Richman, S.P., Tatum, K. and Richman, K. (SPON: William J. Waddell): Monocyte Cytotoxicity Assay in Normal Donors. American Society of Pharmacology and Experimental Therapeutics and the Society of Toxicology, May, l982. 12. Richman, S.P., Woodcock, T.M., Lalley, K., Tatum, K., and Spalding, S: Doxorubicin Concentrations in Human Mononuclear Cells Following Therapy. Am. Soc. of Clin. Oncol., December, l982. 13. Richman, S.P., Tatum, K., Stadig, B., and Richman, K.: Ammonia Exposure In Vitro Depresses Monocyte Cytotoxicity. Am. Assoc. for Cancer Res., December, l982. 14. Richman, S.P., Woodcock, T. M., Lalley, K. et al.: Doxorubicin Concentrations in Human Mononuclear Cells Following Therapy. Proceeding A.S.C.O. 2:247-250, l983. 15. Richman, S.P., Tatum, K., Stadig, B., et al.: Ammonia Exposure In Vitro Depresses Monocyte Cytotoxicity. Proceeding A.A.C.R. 24:2l0, l983. 16. Blumenreich, M.S., Woodcock, T.M., Jones, M.K., Richman, S.P., Gentile, P.S., Kubota, T.T. and Allegra, J.C.: High-Dose Cisplatin (DDP) in Patients (PTS) with Advanced Malignancies. Proc. Am. Assoc. for Clin. Res. May, l984. 17. Blumenreich, M.S., Woodcock, T.M., Richman, S.P., Gentile, P.S., Kubota, T.T., Greenwell, S.K., Jones, M.K. and Allegra, J.C.: High-Dose Cisplatin (DDP) and Vinblastine (VLB) Infusion in Advanced Non-Small Cell Lung Cancer (NSCLC). Proc. Am. Soc. of Clin. Oncol. 3:23l, 1984. 18. Richman, S.P., Lopez-Bernstein, G., Woodcock, T.M., Lalley, K. and Perez-Soler, R.: 8 in Cancer Pharmacology of Doxorubicin Uptake into Human Monocytes In Vitro. Proc. Am. Assoc. of Cancer Res. 25:163, l984. 19. Woodcock, T.M., Allegra, J.C., Richman, S.P., Blumenreich, M.S., Kubota, T.T., Gentile, P.S., Lalley, K.A., Jones, M.K., Greenwell, S.K.: Pharmacology and Phase I Trial of Weekly Daunorubicin (DNR). Proc. Am. Soc. of Clin. Oncol. 3:42, l984. 20. Fischl, M., Lucas, S., Richman, S., Koch, G.: Phase II study of Wellferon and Vincristine in AIDS related Kaposi's sarcoma. Proc. Am. Soc. Onc. 6:2, l987. 21. Feun, L., Clendenin, N.J., Savaraj, N., Benedetto, P., Sridhar, K., Hanlon, J., Collier, M., and Richman, S. Phase I trial of Piritrexim capsules using prolonged low dose administration. Pro. AACR, l988. 22. Richman, S.P., Smith, D., Hilsenbeck, S., and East, D.: Review of Cases of Breast Carcinoma at University of Miami/Jackson Memorial Hospital. American Cancer Society, Florida Division: Proc. Twelfth Annual Cancer Research Seminar for the Researchers of Florida, Abstract #27, 1989. 23. Hussein, A., Ardalan, B., Shanahan, W., Aspinall, R., Gardiner, P.,Shield, M., Richman, S., Benedetto, P., Feun, L., Waldman, S.,Glantz, A., Sklaver,L., and Sridhar, K.: Phase I Continuous (Cont.) Intravenous (IV) Infusion of Carbetimer (CBT) in Refractory Malignancies. American Cancer Society, Florida Division: Proc. Twelfth Annual Cancer Research Seminar for the Researchers of Florida, Abstract #31, 1989. 24. Hussein, A., Ardalan, B., Sklaver, L., Reddy, R., Savaraj, N.,Waldman, S., Richman, S., Feun, L., Hung, S., Benedetto, P., and Sridhar, K.: Chemotherapy (C) of Advanced Carcinomas (Ca) with 5-Fluorouracil and Leucovorin (LV). American Cancer Society, Florida Division: Proc. Twelfth Annual Cancer Research Seminar for the Researchers of Florida, Abstract #35, 1989. 25. Hung, S., Savaraj, N., Reddy, R., Jeffers, L., Schiff, E., Waldman, S.,and Richman, S.: Tamoxifen in the Treatment of Hepatocellular Carcinoma (HCC). Proceedings of the American Cancer Society, Florida Division: Proc. Twelfth Annual Cancer Research Seminar for the Researchers of Florida, Abstract #428, 1989. 26. Hung, S., Savaraj, N., Reddy, R., Jeffers, L., Schiff, E., Waldman, S., and Richman, S.: Tamoxifen in the Treatment of Hepatocellular Carcinoma (HCC). Proc. Am. Soc. of Clin. Oncol. 8:ll0, l989. 27. Ardalan, B., Hussein, A., Sklaver, L., Reddy, R., Benedetto, P., Sridhar, K., Richman, S., Feun, L., Savaraj, N., Waldman, S., and Hung, S.: Chemotherapy (C) of Advanced Carcinoma (Ca) with 5-Fluorouracil (FU) and Leucovorin (LV). Proc. Am. Soc. of Clin. Oncol. 8:ll6, l989. 28. Sridhar, K., Hussein, A., Barmann, A., Benedetto, P., Ardalan, B., Waldman, S., Richman, S., Feun, L., Savaraj, N., Morrell, L., and Donnelly, E.: Phase II Study of Q3 Week IV Bolus Pirarubicin (4'-0-Tetrahydropyranyladriamycin) in Head and Neck Carcinoma (H & N Ca). Proc. 9 Am. Soc. of Clin.Oncol. 9:179, 1990. 29. Waldman, S., Sridhar, K., Richman, S., East D., Berlin, N., Vogel, C., Salewski, E.: Phase II Trial of Pirarubicin (P) in Advanced Breast Ca (BC). Proc. Am. Soc. of Clin. Oncol. 9:50, 1990. 30. Chua, L., Ardalan, B., Sridhar, K.S., Hussein, A., Richman, S. et al. A Phase II Study of Short Term Protracted Infusion with High Dose 5-Fluorouracil with Leucovorin in Colorectal Carcinoma. Proc. ASCO 9:104, 1990. 31. Morrell, L., Ardalan, B., Richman, S., et al. A phase II Study of Thiotepa in Combination with 5-fluorouracil and Leucovorin in Patients with Advanced Breast Cancer. Proc. of ASCO 10: 62, 1991. 32. Sridhar, K.S., Krishan A., Anac, S., Duncan, R., Benedetto, P., Ardalan, B., Samy,T., Feun, L., Savaraj, and Richman, S. Phase I Study of Doxorubicin plus Prochlorperazine as a Resistance Modifiere. Proc. ASCO 10: 106, 1991. 33. Ardalan, B., Sridhar, K., Richman, S., et al. Addition of HJigh Dose Leucovorin to High Dose Infusion of 5-fluorouracil and Low Dose PALA: Effective in Pancreatic Cancer Therapy. Proc. ASCO 10: 139, 1991. 34. Sridhar, K.S., Raub, Jr., W.A., Smith, D., and Richman, S. Lung Cancer: Recent Trends in Smoking History in Lung Cancer Patients. Proc. ASCO 10: 249, 1991. 35. Flores M.R., Cassileth, P., Pozo, C., Sumrall E., Bean, J., Morrell, L., Hurley J., Love, N., Trapido, E., Richman, S. Assessment ofsocioeconomic, cultural health care diversity and patient characteristics in breast cancer patients: an interim analysis. Proc ASCO 13: 454, 1994. 36. Ardalan, B., Ucar, A., Reddy, R., Livingstone, A., Schwade, J., Markoe, A., Richman, S. Phase I trial of low dose PALA and high dose 5-fluorouracil (5-FU) as a short-term infusion concomitantly with radiation therapy in the treatment of adenocarcinoma of the pancreas. 37. Ardalan, B., Donofrio, K., Livingstone, A., Reddy, R., Richman, S. et al. A phase II study of weekly low dose bolus phosphonacetyl-L-aspartic acid (PALA) and 24 hr infusion with high dose fluorouracil (FU) with leucovorin (LV) in colorectal cancer. Proc. ASCO 14:220, 1995. 38. Morrell, L.E., Lee, Y.J., Hurley, J., Arias, M., Richman, S.P., Cassileth,P.A. Phase II Trial of methotrexate, vinblastine, doxorubicin, and cisplatin in the treatment of locally advanced breast cancer. Proc ASCO 16:643, 1997. 39. Ardalan, B., Sparling, L., Livingstone, A., Francheschi, D., Sridhar, K.S., Feun, L.G., Richman, S.P., Triplett, N. Phase II trial of high-dose 24-hour Infusion of 5-fluorodeoxyuridine in patients with inoperable pancreatic cancer (previously failed 5-FU and Gemsar).Proc. ASCO 16 999, 1997 10 18. Other works and publications: 1. Gutterman, J.U., Mavligit, C.M., Reed, R.C., Richman, S.P., McBride, C.M. and Hersh, E.M.: Immunology and immunotherapy of malignant melanoma: Historic review and perspectives for the future. Sem. Onc. 2:l55-l84, l975. 2. Hersh, E.M., Mavligit, G.M. Gutterman, J.U. and Richman, S.P.: Immunotherapy of human cancer. In: Cancer, A Comprehensive Treatise F.F. Becker, Editor, pp. 425-532, Plenum Press, New York, l977. 3. Gutterman, J.U., Mavligit G.M. McBride, G.M., Richman, S.P., Burgess, M.A. and Hersh, E.M.: Postoperative immunotherapy for recurrent melanoma: An updated report. In: Immunotherapy of Cancer: Present Status of Trials in Man. Raven Press, New York 35-56, l977. 4. Gutterman, J.U., Mavligit, G. M., Richman, S.P., Burgess, M.A. and Hersh, E.M.: Chemoimmunotherapy of disseminated malignant melanoma with BCG: Followup report. In: Immunotherapy of Cancer: Present Status of Trials in Man. Raven Press, New York, l03-ll2, l977. 5. Hortobagyi, G.N., Gutterman, J.U., Blumenschein, G.R., Buzdar, A., Burgess, M.A., Richman, S.P., Tashima, C.K., Schwarz, M. and Hersh, E.M.: Chemoimmunotherapy of Advanced Breast Cancer with BCG. In: Immunotherapy of Cancer: Present Status of Trials in Man. New York, Raven Press, l977, pp. 655-663. 6. Hortobagyi, G.N., Gutterman, J.U., Blumenschein, G.R., Buzdar, A.U., Richman, S.P., Wiseman, and C. and Herseh, E.M.: Immunotherapy and chemotherapy for human breast cancer. In: Immunotherapy of Cancer: Present Status of Trials in Man. Raven Press, New York, 32l-345, 1978. 7. Gutterman, J.U., Mavligit, G.M. and Richman, S.P. et al.: Immunotherapy for malignant melanoma. In: Immunotherapy of Human Cancer. Raven Press, New York, 257-265. 8. Gutterman, J.U., Richman, S.P., McBride, C.M. et al.: Immunotherapy for recurrent malignant melanoma: Efficacy of BCG in prolonging the postoperative disease-free interval and survival. In: Recent Results Cancer Research 68:359-362, l979. 9. Richman, S.P., Gutterman, J.U., Hersh, E.M. and Mavligit, G.M.: Immunotherapy of cancer in man. CRC Press for Handbook in Clinical Laboratory Science 335-363, l979. 10. Richman, S.P., Hersh, E.M., Gutterman, J.U. and Mavligit, G.M.: Immune depression in cancer patients: Cell-mediated immunity. CRC Press for Handbook in Clinical Laboratory Science 379-404, l979. 11. Hortobagyi, G.N., Gutterman, J.U., Blumenschein, G.R., Buzdar, A., Burgess, M.A, Richman, S.P., Tashima, C.K., Schwartz, M. and Hersh, E.M.: Chemoimmunotherapy of advanced breast cancer with BCG. In: Recent Results in Cancer Research. 62:143-150, l979. 11 12. Richman, S.P., Hersh, E.M., Gutterman, J.U. et al.: Phase I-II Study of immunotherapy of malignant effusions with BCG cell wall skeleton-P3. The Fifth Chicago Symposium. Cancer Immunology Experimental and Clinical. Crispen (Ed.) Elsevier North Holland, Inc., 473-479, l980. 13. Woodcock, T.M., Allegra, J.C., Richman, S.P., Lalley, K., Kubato, T.T., Blumenreich, M.S., Gentile, P., Jones, M. and Seeger, J.: Pharmacology and Phase I Clinical Studies of Daunorubicin in Patients with Advanced Malignancies. Seminars in Oncology ll:28-32, l984. 14. Seeger, J., Richman, S.P., Allegra, J.C.: Systemic therapy of malignant melanoma. Med. Clin. N. Amer. 70:89-94, l986. 15. Richman, S.P. and Vogel, C.L. Kaposi's sarcoma in Current Therapy in Hematology-Oncology-3. Brain, M.C. and Carbone, P. P. eds., pp. 353-355, l988. 19. Other works accepted for publication: N/A PROFESSIONAL 20. Funded Research Performed (include all grants received in the last five years, identifying the principal investigator): 9/86-12/87 SWOG Subcontract #8645, $48,5l3. Southwest Oncology Group Membership. 12/87 Principal Investigator for Adria Labs, Inc. "Epirubicin, Two-Dose levels vs. Doxorubicin in the Treatment of Disseminated Carcinoma of the Breast" $5,ll2. 1/88 Co-Principal Investigator for Warner-Lambert Co. "Phase I- Study of Cl-908 3 Deazaguanine in Patients with Metastatic Cancer Refractory to Conventional Therapy" $60,055. 2/88 Principal Investigator for Ciba-Geigy. "Comparative Study of CGP-23339A and Etidronate Disodium in Treatment of Hypercalcemia of Malignancy Plus Open-Label Humanitarian Extension" $20,000. 6/89 Principal Investigator for Ciga-Geigy. "Comparison of CGS l694 9A vs. Megestrol Acetate in Post-Menopausal Women with Breast Carcinoma" $l20,000. 6/91 Principal Investigator for CIBA-GEIGY 19/2 Aredia vs. Placebo for the Prevention of Skeletal Related Complications in Patients with Breast Cancer--Chemotherapy. $151,000. 6/91 Principal Investigator for CIBA-GEIGY 18/3 Aredia vs. Placebo for the Prevention of 12 Skeletal Related Complications with Breast Cancer--Hormonal Therapy. $162,000. 11/93 Principal Investigator: Amgen NGN 0252, Phae I Trial of Cyclophosphamide followed by 72 Hour Infusion of Topotecan in Patients with Solid Tumors. 11/15/93-11/14/95 Total Cost $57,000. 8/94 Subcontractor (10% effort): Pain Management Skills for Minority Breast Cancer Patients. Department of Defense, Army Log #2551, Charles S. Cleeland, Ph.D., Principal Investigator: salary.8/15/94-8/14/98, $1,539,115Total Cost 8/15/94-8/14/95, $293,347 Direct Cost 6/94 Subcontractor (10% effort): Cancer Pain Relief Skills for Minority Outpatients, National Institutes of Health, CA 64766, Charles S. Cleeland, Ph.D., Principal Investigator, salary. 6/1/94-5/31/98 Total Cost 6/1/94-5/31/95 Direct Cost Principal Investigator: 1R01 CA64056-01. Breast Rescreening in Minority Women. 10/1/94-9/30/97 Total Annual Cost $280,000.00 21. Editorial responsibilities: Richman, S.P. (consulting reviewer) Oncology Overview. Selected abstracts on prognostic factors, chemotherapy and chemoimmunotherapy of malignant melanoma. International Cancer Research Data Program. National Cancer Institute. May, l983. Richman, S.P. (consulting reviewer) National Institute of Health Special Review Committee to evaluate applications for adult AIDS clinical trial units (ACTUS), National Institute for Allergy and Infectious Disease. October, 1991. 22. Professional and Honorary Organizations (member; officer; date): Society memberships and offices 1. 2. 3. 4. 5. American Association for Cancer Research American College of Physicians American Federation for Clinical Research American Society of Clinical Oncology Southern Medical Association 23. Honors and Awards: 13 Phi Beta Kappa Alpha Omega Alpha American Cancer Society Junior Faculty Award #32l Fellowship, American College of Physicians 24. Post-Doctoral Fellowships: 1972 - 1974 Fellowship, Medical Oncology, Department of Developmental Therapeutics, M.D. Anderson Hospital and Tumor Institute. 25. Other Professional Activities (e.g., papers presented; performance; conference Proceedings; seminar or conference panel member; etc.): TEACHING 26. Teaching Awards Received: N/A 27. Thesis and Dissertation Advising/Post-doctoral student supervision (chairman or committee member; topic; student name; date): N/A* SERVICE 28. University Committee and Administrative Responsibilities: Chief, Division of Medical Oncology Acting Chairman, Dept. of Oncology a. Chairman, Scientific Committee, Kentucky Chapter, American College of Physicians, l984. b. Diagnostic Radiology Chairman - Search Committee, University of Louisville. c. Infection Control Committee - Norton Hospital, Louisville, Kentucky. d. Medical Record Committee - Norton Hospital, Louisville, Kentucky. e. American Cancer Society Institutional Research Grants Review Committee, University of Louisville. f. Radiotherapy Chairman - Search Committee, University of Miami. g. UM/Jackson Hospital Cancer Committee h. UMHC Executive Committee i. UMHC Outpatient Care Committee j. Cancer Center Clinical Research Committee k. Sylvester Clinic Facility Planning Committee l. Cancer Center Search Committee for Director m. Dept of Urology Search Committee for Chairman 14 n. o. p. q. r. s. Cancer Control Search Committee for Director Institutional Review Board (IRB) Sylvester Cancer Center Executrive Committee Sylvester Cancer Center Ethics Committee Sylvester Cancer Center Scientific Steering Committee Sylvester Cancer Center Quality Assurance Committee 29. Community Activities. Leukemia Society Radio Telethon, l984. 15