ANNA S. GUKOVSKAYA, Ph.D.
Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS)
West Los Angeles Healthcare Center (WLA)
11301 Wilshire Blvd, Blg.258, Rm.340, Los Angeles, CA 90073
Phone: (310) 478-3711 x41525. Fax: 310-268-4578
E-Mail: agukovsk@ucla.edu
BIOGRAPHICAL DATA
Place of Birth:
Married:
Children:
Home Address:
Home Phone:
Citizenship:
Chernowitz, Ukraine (former USSR)
Ilya Gukovsky, Ph.D.
Daughter Sonya,
30458 Rainbow Crest Dr, Agoura Hills, CA 91301
(818) 879-9604
USA
EDUCATION & DEGREES
B.Sci, Chemical Physics – 1969, Saratov University, Saratov, Russia (former USSR)
Ph.D., Biochemistry
– 1972, Moscow University, Russia (former USSR).
Ph.D. Thesis: Stacking interaction of nucleotide bases: the
effect of molecular-ion and tautomeric transformations
Doct. Sci, Cell Biology
– 1989, Institute of Cytology, Russian (former USSR) Academy
of Sciences, St.Petersburg (former Leningrad), Russia.
Doct. Sci. Dissertation: Ion transporting systems and
second messengers in lymphocyte activation
Anna S. Gukovskaya, Ph.D.
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PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS
Position
Dates & Institution
Area of Research
Adjunct Professor
Researcher I & II
Associate Researcher
2003 – present.
1998 – 2003
1995 – 1998
David Geffen School of
Medicine,
University of California,
Los Angeles, CA
Signal transduction in
exocrine pancreatic cells.
Molecular and cellular
mechanisms of
pancreatitis.
Cell death pathways in
pancreatitis.
VA Research Career
Scientist
2009 - present
Research Molecular
Physiologist
(GS 12-06 to 14-06)
1999 - present.
Veterans Affairs Greater Los
Angeles Healthcare System,
West Los Angeles Center, Los
Angeles, CA
Mitochondrial
dysfunction in
pancreatitis.
Mechanisms of
pancreatic cancer cell
survival and resistance
to treatments.
Role of reactive oxygen
species and protein
phosphatases in
pancreatic cancer.
Project Scientist
1992 - 1995.
VA La Jolla Medical Center and
UCSD School of Medicine,
University of California,
San Diego, CA
Second messengers in
pancreatic acinar cells:
Ca2+, nitric oxide, cyclic
GMP.
Visiting Professor
1991 - 1992.
Division of Cell Biology, The
Hospital for Sick Children,
Toronto, Ontario, Canada
pH regulation in
neutrophils
Head of Group
1990 - 1992.
Institute of Theoretical and
Experimental Biophysics,
Russian (USSR) Academy of
Sciences, Pushchino, Moscow
Region, Russia
Mechanisms of signal
transduction, activation,
and apoptosis in
lymphocytes.
Director, Pancreatic
Research Group
Anna S. Gukovskaya, Ph.D.
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Senior Research
Scientist
1981 - 1990.
Institute of Biological Physics,
USSR Academy of Sciences &
Center for Bioactive
Compounds, Pushchino, USSR
Ionic mechanisms of
signal transduction in
eukaryotic cells.
Research Scientist
1972 - 1981.
Institute of Biological Physics,
USSR Academy of Sciences,
Pushchino, USSR;
Conformation and
interactions of nucleic
acids.
Graduate Student
1969 - 1972.
Institute of Biochemistry and
Physiology of Microorganisms,
USSR Academy of Sciences,
Pushchino, USSR
Physico-chemical
properties of nucleic acid
constituents
MEMBERSHIPS
Russian (former USSR) Biochemical Society (1972 – 1992).
Russian (former USSR) Physiological Society (1972 – 1992).
American Gastroenterological Association.
American Pancreatic Association.
American Gastroenterological Society.
UCLA-CURE: Digestive Diseases Research Center.
Southern California Research Center for Alcoholic Liver & Pancreatic Diseases and Cirrhosis,
University of Southern California Keck School of Medicine.
UCLA Center for Excellence in Pancreatic Diseases.
UNIVERSITY & VAGLAHS COMMITTEES
VAGLAHS-WLA Subcommittee on Research Safety, 1999-present.
MEMBER OF EDITORIAL BOARD:
Pancreatology (Associate Editor)
Pancreas
World Journal of Gastroenterology
REVIEWER FOR:
American Journal of Physiology - Gastrointestinal & Liver Physiology
American Journal of Physiology - Cell Physiology
American Journal of Pathology
Biochimica et Biophysica Acta
Anna S. Gukovskaya, Ph.D.
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Biochemical Journal
Biochemical Pharmacology
Cancer Research
Cell Calcium
Digestive and Liver Diseases
European Endocrinology Journal
European Journal of Pharmacology
Experimental Cell Research
Gastroenterology
Gut
International Journal of Cancer
Journal of Cell Biology
Journal of Biological Chemistry
Journal of Biochemistry and Cell Biology
Journal of Lipid Research
Journal of Pharmacology and Experimental Therapeutics
Journal of Physiology and Pharmacology (Krakow, Poland)
Laboratory Investigation
Molecular Cancer Therapeutics
Pancreas
World Journal of Gastroenterology
MEMBER, Department of Veterans Affairs Medical Research Merit Review Subcommittee for
Gastroenterology (GAST).
MEMBER (ad hoc), CIGP (Clinical and Integrative Gastrointestinal Pathobiology) Study Section, NIH
Center for Scientific Review.
MEMBER, Executive Committee, Southern California Research Center for ALPD & Cirrhosis.
MEMBER, Hirshberg Foundation for Pancreatic Cancer Research at UCLA.
HONORS
University diploma with highest honors, Saratov University, Saratov, Russia, 1969.
Silver Medal for distinguished young scientists, Exhibition of Scientific Achievements of the USSR,
Moscow, USSR, 1973.
Distinguished Scientist of the Year, the Institute of Biological Physics, USSR Academy of Sciences &
Center for Bioactive Compounds, Pushchino, Moscow Region, USSR, 1982, 1985, 1986.
Visiting Scientist Award, Canadian Medical Research Council, Toronto, Ontario, Canada, 1991.
5 most cited papers - American Journal of Physiology Gastrointestinal & Liver Physiology 286: G1G6, 2004.
Honorary medal from Ernst-Moritz-Arndt University of Greifswald, Germany, 2004.
Honorary diploma from Tohoku Medical Society and Tohoku University School of Medicine, Sendai,
Japan, 2006.
GRANT SUPPORT
Anna S. Gukovskaya, Ph.D.
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1994 - 1998
1995 - 1998
1998 - 2002
1998 - 1999
1999 - 2003
1999 - 2001
1999 - 2002
2000 - 2002
2002 - 2005
2002 - 2007
2002 - 2007
2003 - 2007
2003 - 2008
Veterans Affairs Merit Review
"Mechanisms of acinar cell death in experimental models of pancreatitis"
Principal Investigator: Stephen J. Pandol, M.D.
Co-Investigator: Anna S. Gukovskaya, Ph.D.
1R01 DK51476 (NIH/NIDDK)
"Mechanism of ethanol-induced pancreatitis"
Principal Investigator: Stephen J. Pandol, M.D.
Co-Investigator: Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review
“Molecular mechanisms of experimental pancreatitis”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
UCLA/CURE Pilot & Feasibility Study
“Extracellular matrix and apoptosis in normal and cancer pancreatic cells”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
NIAAA 1P50 AA11999-01
“USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases”
Project 4: “Ethanol and pancreatic injury”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
NIAAA 1P50 AA11999-01
“USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases”
Pilot Project: “Role of non-oxidative and oxidative ethanol metabolites in
activation of NF-kB in pancreatic acinar cells”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review
“Extracellular matrix and apoptosis in normal and cancer pancreatic cells”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
State of California – Health and Human Services Agency
California Cancer Research Program 2PF0071
“Regulation of pancreatic cancer apoptosis by polyphenols”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review
“Reactive oxygen species: survival factor in pancreatic cancer cells”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
1R01 DK59508 (NIH/NIDDK)
“The inflammatory response of the pancreatic acinar cell”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review
“Phosphatidylinositol 3-kinase and the exocrine pancreas”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
1R01 DK59936 (NIH/NIDDK)
"Apoptosis and necrosis in pancreatitis"
Principal Investigator: Anna S. Gukovskaya, Ph.D.
1U56 AA0114643 (NIH/NIAAA)
“Role of alcohol in pancreatic acinar cell death”
Principal Investigator: Duane Smoot, M.D.
Anna S. Gukovskaya, Ph.D.
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2005 – 2006
2005 - 2009
2006 – 2008
2006 - 2010
2006 - 2010
2007 – 2010
2007 – 2009
2007 – 2011
2007 – 2012
2008 - 2013
2009 - 2013
2010 - 2014
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
Hirshberg Foundation for Pancreatic Cancer Research (private donation)
“Sensitization of pancreatic cancer to gemcitabine chemotherapy by inhibiting
anti-apoptotic XIAP with herb-derived embelin”
Principal Investigator: Mouad Edderkaoui, Ph.D.
Mentor: Anna S. Gukovskaya, Ph.D.
5P60 AA11999 (NIH/NIAAA)
“USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases”
Project 4: “Ethanol and protein kinase C in pancreatitis”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
R21 AA016010 (NIH/NIAAA)
“Alcohol and the exocrine pancreas ER stress responses”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Fred S. Gorelick, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review 103
“Nox4, protein tyrosine phosphatases, and pancreatic cancer cell survival”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
1R01CA119025 (NIH/NCI)
“NADPH oxidase and pancreatic cancer cell survival”
Principal Investigator: Anna S. Gukovskaya, Ph.D.
AGA Foundation Designated Research Scholar Award in Pancreatitis
“Bcl-2 proteins regulate death responses of acute pancreatitis”
Principal Investigator: Olga A. Mareninova, Ph.D.
Mentor: Anna S. Gukovskaya, Ph.D.
1R03AA016336-01A1 (NIH/NIAAA)
“The effect of alcohol on NADPH oxidase structure in pancreatic stellate cells”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review
“Inflammation mediates necrosis in pancreatitis”
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
NIH/NCCAM 1P01AT003960-01
“UCLA Center for Excellence in Pancreatic Diseases”
Project 1: “Phytonutrients and metabolism in pancreatic diseases” (Director:
VLW.Go).
Principal Investigator: Stephen J. Pandol, M.D.
Co-Principal Investigator: Anna S. Gukovskaya, Ph.D.
2R01DK059936 (NIH/NIDDK)
"Apoptosis and necrosis in pancreatitis"
Principal Investigator: Anna S. Gukovskaya, Ph.D.
NIAAA 1P60 AA11999
“Southern California Research Center for Alcoholic Liver and Pancreatic Diseases”
(Director: H.Tsukamoto)
Project 4: “Alcohol Abuse and Pancreatic Necrosis”
Principal Investigator (Aims 2 & 3): Anna S. Gukovskaya, Ph.D.
Veterans Affairs Merit Review
“Mitochondrial dysfunction, permeability transition pore, and acute pancreatitis”
Anna S. Gukovskaya, Ph.D.
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Principal Investigator: Anna S. Gukovskaya, Ph.D.
PATENTS GRANTED
1.
US 6,953,786 B2 from October 11, 2005. “Compositions comprising plant-derived
polyphenolic compounds and inhibitors of reactive oxygen species and methods of using
thereof”.
PATENTS SUBMITTED:
1.
Translocation Inhibitors of Protein Kinase C Delta and Protein Kinase C Epsilon for the
Treatment of Pancreatitis. Provisional Patent Application, filed 15 April 2004 (with S.J.
Pandol).
2.
Methods of using NOX4 as a biomarker for cancer. U.S. Provisional Patent Application No.
60/662,814, filed 18 March 2005 (with S.J. Pandol).
3.
Inhibitors of X-linked inhibitor of apoptosis protein (XIAP) and receptor-interacting protein (RIP)
in the treatment of pancreatitis. UCLA Case No. 2006-067-1 (with S.J. Pandol).
TEACHING AND MENTORING
Mentored 5 PhD graduate students: 3 students for PhD degree in Biochemistry and Cell Biology at
the Institute of Biological Physics, Biological Center of the USSR Academy of Sciences,
Pushchino, USSR (1986 - 1991); Dr. Mouad Edderkaoui in the Cell Physiology PhD program,
Ernst-Moritz-Arndt University of Greifswald, Germany (2002 - 2004); and Izumi Ohno, MD, in the
Molecular Biology PhD program, Chiba University School of Medicine, Japan (2005 - 2008).
Regularly lectures at the GI Fellow conference (UCLA-VAGLAHS GI training fellowship program).
Mentored more than 55 MD and PhD postdoctoral fellows, medical students, undergrad students,
technical stuff, and other trainees (see the list below) in the Pancreatic Research Group at the
University of California, San Diego and VA La Jolla Medical Center (1992 - 1995), and the
University of California, Los Angeles and VAGLAHS-WLA (1996 - present), and taught them the
physiology and pathophysiology of exocrine pancreas in relation to mechanisms and treatments
of pancreatic disorders. Among the MD/PhD trainees, more than 20 came from abroad to
advance their expertise. A number of the trainees have advanced to positions of Associate or
Assistant Professor, group leader, etc. at their institutions.
Trained and supervised investigators, including junior faculty, from a number of UCLA and
VAGLAHS-WLA laboratories in the areas of biochemistry and cell biology. Consulted and
collaborated with MD and PhD investigators involved in basic and clinical research on pancreatic
disorders from institutions both in the US (Yale University and VA Connecticut Healthcare
System; UCSD and VA La Jolla Medical Center; University of Southern California; Harbor-UCLA
Medical Center) and abroad (Ernst-Moritz-Arndt University of Greifswald, Germany; University of
Liverpool, Great Britain; etc.). This involved help in generating hypotheses and developing
research protocols, and instruction and assistance in various assays and techniques. The
significance of this instruction has been not only in educating the investigators in new areas and
Anna S. Gukovskaya, Ph.D.
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thus enhancing their research, but also in fostering new approaches and collaborations between
researchers from different laboratories.
The mentoring, consulting, and collaborations resulted in more than 40 publications co-authoring
trainees and national and international collaborators (including VA scientists) in peer reviewed
journals such as Gastroenterology, Journal of Biological Chemistry, American Journal of
Physiology, and others.
Regularly presents and lectures at seminars and conferences at UCLA and VAGLAHS-WLA, as well
as at the weekly Pancreatic Research Group Seminar, on molecular and cell biology and
pathobiology of pancreatic disorders; mechanisms of ethanol’s effects on exocrine pancreas;
molecular mechanisms of cell death; apoptotic pathways in pancreatic cancer; etc.
INVITED LECTURES AND SEMINARS (recent selected)
12/09/2003 – “Reactive Oxygen Species: Pro-survival Factor in Pancreatic Cancer” – AstraZeneca
Lecture at VAGLAHS-WLA and CURE: Digestive Diseases Research Center.
12/09/2004 – “Cell Death in Pancreatitis” – Lecture at the Department of Gastroenterology,
Endocrinology and Nutrition, Ernst-Moritz-Arndt University of Greifswald, Germany (Chief, Prof.
Marcus M. Lerch).
01/27/2005 – “Role of Oxidative Stress in Pancreatic Carcinogenesis” – Hirshberg Foundation Annual
Symposium on Pancreatic Cancer, UCLA.
05/17/2005 – “Apoptotic Cell Signaling (Cell Death in Pancreatitis)” – AGA Research Symposium at
the DDW-2005, Chicago.
05/18/2006 – “Cell Death in Pancreatitis. Effects of Alcohol” – 1st International Symposium on
Alcoholic Liver and Pancreatic Diseases, Los Angeles, CA.
09/02/2006 – “Supramaximal Cholecystokinin Stimulates Apoptosis and Necrosis in Pancreatic
Acinar Cells: Role in Pancreatitis” – 16th International Symposium on Regulatory Peptides
(REGPEP-06), Hakone, Japan (invited speaker - sponsored Symposium).
09/04/2006 – “ROS and pancreatic cancer cell survival” – Lecture at the Division of Gastroenterology,
Tohoku University School of Medicine, Sendai, Japan (Chief, Prof. Tooru Shimosegawa).
11/13/2006 – “PI3-kinase in pancreatitis” – International Research Workshop “Pancreatitis and
Calcium Signaling”, Liverpool, UK.
11/14/2006 – “Mechanisms of cell death responses in pancreatitis” – International Research
Workshop “Pancreatitis and Calcium Signaling”, Liverpool, UK.
12/05/2006 – “Mechanisms of cell death in experimental pancreatitis” – Lecture at the Division of
Gastroenterolgy, Department of Internal Medicine/ Investigative & Clinical Training Programs in
Digestive Diseases, VA Connecticut Healthcare System and Yale University School of Medicine,
New Haven, CT (Chief, Prof. Fred S. Gorelick).
02/05/2007 – “ROS: a prosurvival factor in pancreatic cancer cells” – 3d Annual Agi Hirshberg
Symposium on Pancreatic Cancer, UCLA.
07/07/2007 – “Mitochondrial mechanisms of cell death in pancreatitis” – 39th Meeting of the
European Pancreatic Club, Newcastle-upon-Tyne, UK.
10/18/2007 – “Mitochondrial mechanisms of death responses in pancreatitis” – 2nd International
Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Kobe, Japan.
Anna S. Gukovskaya, Ph.D.
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6/10/2008 – “Paradigm shift: Pancreatitis as a lysosomal disease?” – AstraZeneca Lecture at
VAGLAHS-WLA and CURE: Digestive Diseases Research Center, Los Angeles.
11/08/2008 – “Autophagy in pancreatitis” – American Pancreatic Association and Lustgarten
Foundation Symposium “The Chronic Pancreatitis to Pancreatic Cancer Continuum”, Chicago.
11/13/2008 – “Acinar cell death in pancreatitis” – Lecture at the Pancreas Research Group and
Division of Infectious Diseases, Department of Medicine, New South Wales University, Sydney,
Australia.
11/17/2008 – “Autophagy is impaired in acute pancreatitis” – Lecture at the Australian Health and
Medical Research Congress 2008, Brisbane, Australia.
12/05/2008 – “Autophagy in acute pancreatitis” – 10th annual symposium of the Southern California
Research Center for ALPD & Cirrhosis, University of Southern California, Pasadena, CA.
2/02/2009 – “Autophagy in the progression from pancreatitis to pancreatic cancer” – 5th annual Agi
Hirshberg Symposium on pancreatic cancer, UCLA.
7/04/2009 – “Autophagy is impaired in pancreatitis” – European Pancreatic Club 2009 meeting,
Szeged, Hungary.
7/29/2009 – “Cell death pathways in pancreatitis” – XXXVI International congress of Physiological
Sciences 2009 (IUPS2009), Kyoto, Japan.
9/24/2009 – “Mechanisms of death responses in pancreatitis” – Lecture at the University of Southern
California Research Center for Liver Diseases, Pasadena, CA.
11/06/2009 – “Novel pathways regulating pancreatic cancer cell survival: ROS, NOXes, and PHLPPs”
– 40th anniversary meeting of American Pancreatic Association and Japan Pancreas Society,
Honolulu, HI, USA.
12/04/2009 – “Mechanisms and consequences of impaired autophagy in pancreatitis” – 11th annual
symposium of the Southern California Research Center for ALPD & Cirrhosis, University of
Southern California, Pasadena, CA.
1/28/2010 – “Mitochondrial dysfunction in pancreatitis” – Lecture at the “ER -mitochondrial cross-talk”
mini-workshop at the University of Southern California Research Center for Liver Diseases,
Pasadena, CA.
6/22/2010 – “Organellar damage in pancreatitis: new pathogenic mechanisms” – CURE Lecture
Series, CURE: Digestive Diseases Research Center, UCLA-VAGLAHS, Los Angeles.
9/15/2010 – “Lysosomal dysfunction and impaired autophagy in alcoholic pancreatitis” – 15th ISBRA
World Congress (invited speaker), Paris, France.
Anna S. Gukovskaya, Ph.D.
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BIBLIOGRAPHY
RESEARCH PAPERS (Peer-Reviewed)
A. PUBLISHED
1.
BI Sukhorukov, AS Gukovskaya, LV Sukhoruchkina, GI Lavrenova. (1972) Optical properties
and molecular structure of nucleic acids and their components. V. Spectrophotometric
determination of thermodynamic parameters for protolytic reactions of cytosine and its N- and
O-methyl derivatives, Biofizika 17:5-11 (in Russian).
2.
VL Antonovskii, AS Gukovskaya, TM Prokop'eva, BI Sukhorukov. (1972) Protonation of
thymine, uracil and its 5-haloid derivatives, Doklady Akad Nauk SSSR 205:461-464.
3.
VL Antonovskii, AS Gukovskaya, BI Sukhorukov, II Chervin. (1972) A method for
determination of association equilibrium constants from NMR data, Zh Fizicheskoi Khimii
46:2902-2903 (in Russian).
4.
AS Gukovskaya, BI Sukhorukov, TM Prokop'eva, VL Antonovskii. (1972) Spectrophotometric
study of the protonation and deprotonation of thymine, uracil and its 5-haloid derivatives,
Izvestia Akad Nauk SSSR (chemical section) 12:2682-2688 (in Russian).
5.
AS Gukovskaya, GV Nekrasova, II Chervin, BI Sukhorukov, VL Antonovskii. (1973) Stacking
interaction of nitrogenous heterocycles. Association in aqueous solutions of 6,9-dimethyladenine, 1-methyl-4 methylaminopyrazolo [3,4-d] pyri-midine and their mixtures with
uracil and cytosine methyl derivatives, Biofizika 18:382-384 (in Russian).
6.
AS Gukovskaya, II Chervin, BI Sukhorukov, VL Antonovskii. (1973) NMR study of the effect of
protonation of nucleic acid bases on their stacking interaction, Biofizika 18:557-559 (in
Russian).
7.
VL Antonovsky, AS Gukovskaya, GV Nekrasova, BI Sukhorukov, II Tchervin. (1973) Studies
of intermolecular interactions of nucleic acid bases in aqueous solution by the proton magnetic
resonance method. Self-association of 6, 9-dimethyladenine and its pyrazole analogue, and
their association with methyl-substituted cytosine and uracil, Bioch Biophys Acta 331:9-20.
8.
AS Gukovskaya, VL Antonovskii, GV Nekrasova, BI Sukhorukov. (1974) Determination of the
tautomeric and molecular-ion equilibria of uracil, Biofizika 19:790-797 (in Russian).
9.
AS Gukovskaya, VL Antonovskii, BI Sukhorukov, II Chervin. (1974) Effect of ionization of the
nitrogenous heterocycles on their stacking interaction, Izvestia Akad Nauk SSSR (chemical
section) 10:1242-1248 (in Russian).
10.
AS Gukovskaya, BI Sukhorukov, IY Gukovsky.(1975) The effect of solvent salt composition
on the stoichiometry and stability of polynucleotide-monomer complexes, Biofizika 20:11271128 (in Russian).
11.
AS Gukovskaya, NM Gusenkova, BI Sukhorukov. (1978) Interaction of complementary
nucleoside triphosphates with polycytidylic template, Studia biophysica 67:17-18.
Anna S. Gukovskaya, Ph.D.
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12.
AS Gukovskaya, IY Gukovsky, BI Sukhorukov. (1978) Study of salt effects on adenosinepolyuridylic acid interaction, Studia biophysica 67:15-16.
13.
AS Gukovskaya, VN Lanin, BI Sukhorukov. (1978) A study of the interaction of polycytidylic
acid with guanosine 5'-triphosphate at neutral pH, Biofizika 23:208-212 (in Russian).
14.
AS Gukovskaya, NM Gusenkova, VN Lanin, BI Sukhorukov. (1978) Interaction of
complementary and non-complementary nucleoside triphosphates with polycytidylic acid,
Biofizika 23:991-994 (in Russian).
15.
BI Sukhorukov, IY Gukovsky, AI Petrov, AS Gukovskaya, AA Mayevsky, NM Gusenkova.
(1980) Interactions and self-organization of nucleic bases, nucleotides and polynucleotides
into ordered structures. Effect of ionization and solvent salt composition, Int J Quantum
Chemistry 17:339-359.
16.
IY Gukovsky, AS Gukovskaya, BI Sukhorukov. (1980) Effect of ionization of components on
complex formation between adenosine and polyuridylic acid, Studia biophysica 79:49-50.
17.
AS Gukovskaya, IY Gukovsky, AM Vexler, VI Popov, AA Budnitsky, ME Saxon. (1980) Action
of phalloidin on the mitotic cycle in Chinese hamster fibroblasts, Naturwissenschaften 67:196197.
18.
IY Gukovsky, AS Gukovskaya, AG Sukhomudrenko, BI Sukhorukov. (1980) Calorimetric
study of the complexes between polyuridylic acid and adenylic nucleotides, Nucleic Acids Res.
9:4061-4079.
19.
IY Gukovsky, AS Gukovskaya. (1982) Thermodynamics of GC interactions in poly(C)
complexes with quanosine and deoxyguanosine, Studia biophysica 87:83-84.
20.
IY Gukovsky, AS Gukovskaya. (1982) Thermodynamics of complex formation between
poly(U) and adenylic nucleotides, Studia biophysica 87:85-86.
21.
IY Gukovsky, AS Gukovskaya, BI Sukhorukov. (1983) Effect of ionization of the system
components on the interaction between adenosine and polyuridylic acid. 1. Deprotonation of
the polynucleotide, Biofizika 28:381-387 (in Russian).
22.
IY Gukovsky, AS Gukovskaya, BI Sukhorukov. (1983) 2. Effect of adenosine protonation on
its interaction with polyuridylic acid, Biofizika 28, 565-569 (in Russian).
23.
AS Gukovskaya, VP Zinchenko, VV Ryabichenko, EI Astashkin. (1983) Redistribution of
intracellular Ca2+ in mitogen-stimulated human blood lymphocytes, Gen Physiol Biophys.
2:395-407.
24.
AS Gukovskaya, VP Zinchenko, VV Ryabichenko, EI Astashkin. (1984) Membrane potential
of human peripheral blood lymphocytes. Factors determining the membrane potential, Biol
Membrany 1:191-199 (in Russian).
25.
AS Gukovskaya, VP Zinchenko, IS Nikolaeva, EI Astashkin. (1984) Membrane potential of
human peripheral blood lymphocytes. Effect of ionophore A23187 and concanavalin A, Biol
Membrany 1:317-323 (in Russian).
Anna S. Gukovskaya, Ph.D.
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26.
AS Gukovskaya. (1984) The role of ions in lymphocyte activation, Uspekhi Sovremennoi
Biologii. 97:179-192 (in Russian).
27.
AS Gukovskaya, VP Zinchenko. (1985) Effect of calmodulin antagonists on the membrane
potential and K+ permeability of thymocytes, Doklady Akad Nauk SSSR 281:978-981 (in
Russian).
28.
AS Gukovskaya, VP Zinchenko. (1985) Effect of the Ca2+ ionophore A23187 and
concanavalin A on the membrane potential and potassium permeability of thymocytes,
Biofizika 30:919-920 (in Russian).
29.
AS Gukovskaya, VP Zinchenko, EI Astashkin. (1985) Effects of calmodulin antagonists on
membrane potential, potassium permeability and mitogenic response of lymphocytes,
Biokhimiya 50:786-794.
30.
AS Gukovskaya, VP Zinchenko. (1985) The effects of ionophore A23187 and concanvalin A
on the membrane potential of human peripheral blood lymphocytes and rat thymocytes, Bioch
Biophys Acta 815:433-440.
31.
AS Gukovskaya, VP Zinchenko, VV Petrunyaka, BI Khodorov, YV Evtodienko. (1986)
Regulation of free cytosolic Ca2+ by intracellular compartments in rat thymocytes. MgATPsensitive non-mitochondrial pool of Ca2+, Biol Membrany 3:71-78 (in Russian)
32.
AS Gukovskaya, VP Zinchenko, VV Petrunyaka, BI Khodorov, YV Evtodienko. (1986)
Properties of different Ca2+ pools in permeabilized rat thymocytes, Eur J Biochem. 161:249256.
33.
AS Gukovskaya, VP Zinchenko. (1986) Mechanisms of mitogen-induced rise of free cytoplasmic
Ca2+ in rat thymocytes. The role of cytoplasmic pH, Biol Membrany 3:920-930 (in Russian).
34.
VV Ryabichenko, AS Gukovskaya, IS Nikolaeva, EI Astashkin. (1986) Effect of quinine, a
blocator of Ca2+ -activated potassuim channels, on mitogenic lymphocyte stimulation,
Tsitologiya (Cytology) 28:91-95 (in Russian).
35.
AS Gukovskaya, VP Zinchenko. (1987) Mitogen-induced changes in free cytosolic Ca2+
concentration in rat thymocytes, Biofizika 32:163-164 (in Russian).
36.
AS Gukovskaya, VP Zinchenko, YA Mantsygin. (1987) Effect of SH reagents on free cytosolic
Ca2+ concentration in lymphocytes, Ukr Biokhim J. 59:39-42 (in Russian).
37.
AS Gukovskaya, VP Zinchenko, BI Khodorov. (1987) Properties of the mitogen-activated
system of Ca2+ transport in lymphocyte plasma membrane, Biol. Membrany 4:923-931 (in
Russian).
38.
AS Gukovskaya, VP Zinchenko. (1988) Changes in the cytoplasmic pH of rat thymocytes
under the action of the mitogen concanavalin A and phorbol ester TPA, an activator of protein
kinase C, Ukr. Biokhim. Zh. 60:40-46 (in Russian).
Anna S. Gukovskaya, Ph.D.
Page 12
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39.
EI Astashkin, AS Gukovskaya, AM Surin, IS Nikolaeva, YV Slavich, AF Kolomiets, AV Fokin.
(1988) Effect of 2-(-hydrotetrafluoroethyl) benzimidazole on the free cytosolic Ca2+
concentration and membrane potential of rat thymocytes, Doklady Akad Nauk SSSR 300:249252 (in Russian).
40.
AS Gukovskaya, HA Pulido, VP Zinchenko. (1989) Effect of inhibitors of arachidonic acid
oxidation on the mitogen-induced changes in the cytoplasmic pH and free Ca2+ concentration
in rat thymocytes, Doklady Akad Nauk SSSR 304:1507-1511 (in Russian).
41.
AI Astashkin, AM Surin, AS Gukovskaya, IS Nikolaeva, AV Lazarev. (1989) Mechanisms of
the effects of Cholera toxin and its -subunit on free cytosolic Ca2+ concentration, Biol
Membrany 6:395-403 (in Russian).
42.
AS Gukovskaya, HA Pulido, VP Zinchenko, YV Evtodienko. (1989) Inhibitors of arachidonic
acid metabolism eliminate the increase in cytosolic free calcium induced by the mitogen
concanavalin A in rat thymocytes, FEBS Letters 244:461-464.
43.
AS Gukovskaya, HA Pulido, VP Zinchenko. (1990) Inhibitors of arachidonic acid oxidation
reduce the [Ca2+]i rise evoked in rat thymocytes by Ca2+ ionophore ionomycin, Biol Membrany
7:31-35 (in Russian).
44.
AS Gukovskaya, VP Zinchenko, BI Khodorov, EJ Cragoe,Jr. (1990) The relationship between
mitogen-induced changes in the cytoplasmic pH and free Ca2+ concentration in rat
thymocytes, Biochim Biophys Acta 1051:242-249.
45.
EI Astashkin, AM Surin, IS Nikolaeva, AS Gukovskaya. (1990) Neither Cholera toxin nor its subunit raise cytosolic free Ca2+ concentration in eukaryotic cells, Cell Calcium 11:419-424.
46.
AS Gukovskaya, HA Pulido, VV Petrunyaka, VP Zinchenko, VV Bezuglov. (1990)
Lipoxygenase inhibitors suppress the rise in free cytoplasmic calcium induced by ionomycin in
rat thymocytes, Cell Calcium 11:539-546.
47.
SM Kotelevskaya, VP Zinchenko, VV Petrunyaka, YN Korystov, II Kruman, AS Gukovskaya.
(1991) The role of changes in Ca2+ transport in dexamethazone-induced apoptosis
(programmed cell death) in thymocytes, Tsitologiya (Cytology) 33:166-171 (in Russian).
48.
AS Gukovskaya. (1991) G proteins in T cell signal transduction, Immunology Lett. 31:1-10.
49.
AS Gukovskaya, SM Kotelevskaya, ES Trepakova, VP Zinchenko. (1992) Effect of the SH
reagent thimerosal on Ca2+ homeostasis in thymocytes, Biol Membrany 9:158-165 (in Russian).
50.
II Kruman, AS Gukovskaya, VV Petrunyaka, IP Beletsky, ES Trepakova. (1992) Apoptosis of
murine S147 thymoma cells induced by cold shock, J Cell Physiol. 153:112-117.
51.
AS Gukovskaya, SM Kotelevskaya, VP Zinchenko, ES Trepakova. (1992) Effect of the
sufhydryl reagent thimerosal on cytosolic free Ca2+ and membrane potential of thymocytes,
Biochim Biophys Acta 1111:65-74.
52.
A Nanda, AS Gukovskaya, J Tseng, S Grinstein. (1992) Activation of vacuolar-type proton
pumps by protein kinase C. Role in neutrophil pH regulation, J Biol Chem 262:22740-22744.
Anna S. Gukovskaya, Ph.D.
Page 13
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53.
VV Shaposhnikova, OR Dobrovinskaya, AS Gukovskaya, ES Trepakova, VN Korystov. (1993)
On the role of intracellular Ca2+ and pH in thymocyte death after irradiation, FEBS Lett
324:274-276.
54.
AS Gukovskaya, SJ Pandol. (1994) Nitric oxide production regulates cGMP formation and
calcium influx in pancreatic acinar cells, Am J Physiol Gastrointest Liver Physiol. 266:G350G356.
55.
SJ Pandol, MS Schoeffield-Payne, AS Gukovskaya, RE Rutherford. (1994) Sphingosine
regulates Ca2+ ATPase and reloading of intracellular Ca2+ stores in the pancreatic acinar cell,
Biochim Biophys Acta 1195:45-50.
56.
AS Gukovskaya, SJ Pandol. (1995) Dual regulation of cyclic GMP formation in pancreatic
acinar cells by calcium and calcium-binding proteins, Am J Physiol Gastrointest Liver Physiol.
268:G900-G907.
57.
AS Gukovskaya, P Perkins, V Zaninovic, D Sandoval, R Rutherford, T Fitzsimmons, SJ
Pandol, S Poucell-Hatton. (1996) Mechanisms of cell death after pancreatic duct obstruction in
the opossum and the rat, Gastroenterology 110:875-884. PMID: 8608898
58.
D Sandoval, AS Gukovskaya, P Reavey, S Gukovsky, A Sisk, P Braquet, SJ Pandol, S
Poucell-Hatton. (1996) The role of neutrophils and platelet-activating factor in mediating
experimental pancreatitis, Gastroenterology 111:1081-1091. PMID: 8831604
59.
AS Gukovskaya, IY Gukovsky, V Zaninovic, M Song, D Sandoval, S Gukovsky, SJ Pandol.
(1997) Pancreatic acinar cell produce, release and respond to tumor necrosis factor-: Role in
regulating cell death and pancreatitis, J Clin Invest. 100:1853-1862. PMID: 9312187
60.
X Xu, Z Weizhong, J Diar, AS Gukovskaya, RJ Brown, SJ Pandol, S Muallem. (1997) nNOS
and Ca2+ influx in pancreatic acinar and submandibular salivary gland cells, Cell Calcium
22:217-228. PMID: 9330792
61.
IY Gukovsky, AS Gukovskaya, T Blinman, V Zaninovic, SJ Pandol. (1998) Early NF-B
activation is associated with hormone-induced pancreatitis, Am J Physiol Gastrointest Liver
Physiol. 275:G1402-G1414. PMID: 9843778
62.
M Song, V Zaninovic, D Kim, I Gukovsky, AS Gukovskaya, K Kang, SJ Pandol. (1999)
Amelioration of rat cerulein pancreatitis in by guamerin-derived peptide, a novel elastase
inhibitor, Pancreas 18:231-239. PMID: 10206480
63.
SJ Pandol, S Periskic, I Gukovsky, V Zaninovic, Y Jung, Y Zong, TE Solomon, AS
Gukovskaya, H Tsukamoto. (1999) Ethanol diet increases the sensitivity of rats to pancreatitis
induced by cholecystokinin octapeptide, Gastroenterology 117:706-716. PMID: 10464148
64.
AS Gukovskaya, S Gukovsky, SJ Pandol. (2000) Endoplasmic reticulum Ca 2+-ATPase
inhibitors stimulate membrane guanylate cyclase in pancreatic acinar cells, Am J Physiol Cell
Physiol. 278:C363-C371. PMID: 10666032
Anna S. Gukovskaya, Ph.D.
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65.
V Zaninovic, AS Gukovskaya, I Gukovsky, M Mouria, SJ Pandol. (2000) Cerulein upregulates
ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells, Am J
Physiol Gastrointest Liver Physiol. 279:G666-G676. PMID: 11005752
66.
TA Blinman, I Gukovsky, M Mouria, V Zaninovic, E Livingston, SJ Pandol, A.S.Gukovskaya.
(2000) Activation of pancreatic acinar cells upon isolation from tissue: upregulation of
cytokines via p38 MAP kinase, Am J Physiol Cell Physiol. 279:C1993-C2002. PMID:
11078716
67.
E Vaquero, I Gukovsky, V Zaninovic, AS Gukovskaya, SJ Pandol. (2001) Localized
pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced
pancreatitis, Am J Physiol Gastrointest Liver Physiol. 280:G1197-G1208. PMID: 11352813
68.
AS Gukovskaya, M Mouria, I Gukovsky, CN Reyes, VN Kasho, LD Faller, SJ Pandol. (2002):
Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats,
Gastroenterology 122:106-118. PMID: 11781286
69.
AS Gukovskaya, E Vaquero, V Zaninovic, FS Gorelick, AJ Lusis, ML Brennan, S Holland, SJ
Pandol (2002) Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in
murine experimental acute pancreatitis, Gastroenterology 122:974-984. PMID: 11910350
70.
M Beil, J Leser, MP Lutz, AS Gukovskaya, T Seufferlein, G Lynch, SJ Pandol, G Adler.
(2002) Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells
during pancreatitis, Am J Physiol Gastrointest Liver Physiol 282:G450-G460. PMID: 11841995
71.
M Mouria, AS Gukovskaya, Y Jung, P Buechler, OJ Hines, HA Reber, SJ Pandol. (2002)
Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome
c release and apoptosis. Int J Cancer 98:761-769. PMID: 11920648
72.
AS Gukovskaya, I Gukovsky, Y Jung, M Mouria, SJ Pandol. (2002) Cholecystokinin induces
caspase activation and mitochondrial dysfunction in pancreatic acinar cells: Roles in cell injury
processes of pancreatitis. J Biol Chem 277: 22595-22604. PMID: 11964411
73.
I Gukovsky, CN Reyes, EC Vaquero, AS Gukovskaya, SJ Pandol. (2003) Curcumin
ameliorates ethanol and nonethanol experimental pancreatitis, Am J Physiol Gastrointest Liver
Physiol 284: G85-G95. PMID: 12488237
74.
P Büechler, AS Gukovskaya, M Mouria, MC Büechler, MW Büchler, H Friess, SJ Pandol, HA
Reber, OJ Hines. (2003) Prevention of metastatic pancreatic cancer growth in vivo by
induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas 26:264-273.
PMID: 12657953
75.
EC Vaquero, M Edderkaoui, KJ Nam, I Gukovsky, SJ Pandol, AS Gukovskaya.
(2003) Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial
and nonmitochondrial pathways. Gastroenterology 125: 1188-1202.
PMID: 14517801
76.
A Lugea, I Gukovsky, AS Gukovskaya, SJ Pandol. (2003) Ethanol metabolites alter extracellular
matrix protein degradation in pancreatic acinar cells. Gastroenterology 125: 1845-1859. PMID:
14724836
Anna S. Gukovskaya, Ph.D.
Page 15
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77.
AS Gukovskaya, S Hosseini, A Satoh, JH Cheng, KJ Nam, I Gukovsky, SJ Pandol. (2004)
Ethanol differentially regulates NF-κB activation in pancreatic acinar cells through calcium and
protein kinase C pathways. Am J Physiol Gastrointest Liver Physiol 286: G204-G213. PMID:
12958018
78.
I Gukovsky, JH Cheng, KJ Nam, OT Lee, A Lugea, L Fischer, JM Penninger, SJ Pandol, AS
Gukovskaya. (2004) Phosphatidylinositide 3-kinase gamma regulates key pathologic responses
to cholecystokinin in pancreatic acinar cells. Gastroenterology 126: 554-566. PMID: 14762792
79.
EC Vaquero, M Edderkaoui, SJ Pandol, I Gukovsky, AS Gukovskaya. Reactive oxygen species
produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. (2004) J Biol Chem
279: 34643-34654. PMID: 15155719
80.
A Satoh, AS Gukovskaya, JM Nieto, JH Cheng, I Gukovsky, JR Reeve, Jr., T Shimosegawa, SJ
Pandol. (2004) Protein kinase C delta and epsilon regulate NF-kB activation induced by
cholecystokinin and TNF-α in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol
287: G582-G591. PMID: 15117677
81.
AS Gukovskaya, SJ Pandol. (2004) Cell death pathways in pancreatitis and pancreatic cancer
(Review). Pancreatology 4: 567-586. PMID: 15550766
82.
L Fischer, AS Gukovskaya, SH Young, I Gukovsky, A Lugea, P Buechler, JM Penninger, H
Friess, SJ Pandol. (2004) Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic
acinar cells through inhibition of sarco-endoplasmic reticulum Ca2+-ATPase (SERCA). Am J
Physiol Gastrointest Liver Physiol 287: G1200-G1212. PMID: 15271649
83.
A Satoh, AS Gukovskaya, M Edderkaoui, MS Daghighian, JR Reeve, Jr., T Shimosegawa, SJ
Pandol. (2005) Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via
protein kinase C and proline-rich tyrosine kinase 2. Gastroenterology 129:639-651. PMID:
16083718
84.
M Edderkaoui, P Hong, EC Vaquero, JK Lee, L Fischer, H Friess, MW Buchler, MM Lerch, SJ
Pandol, AS Gukovskaya. (2005) Extracellular matrix stimulates reactive oxygen species
production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH
oxidase. Am J Physiol Gastrointest Liver Physiol 289:G1137-G1147. PMID: 16037546
85.
OA Mareninova, K-F Sung, P Hong, A Lugea, SJ Pandol, I Gukovsky, AS Gukovskaya. (2006)
Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem 281:33703381. PMID: 16339139
86.
YL Wang, R Hu, A Lugea, I Gukovsky, D Smoot, AS Gukovskaya, SJ Pandol. (2006) Ethanol
feeding alters death signaling in pancreas. Pancreas 32:351-359. PMID: 16670617
87.
A Satoh, AS Gukovskaya, JR Reeve, Jr, T Shimosegawa, SJ Pandol. (2006) Ethanol sensitizes
NF-kB activation in pancreatic acinar cells through effects on protein kinase C epsilon. Am J
Physiol Gastrointest Liver Physiol 291:G432-G438. PMID: 16574982
Anna S. Gukovskaya, Ph.D.
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88.
A Lugea, L Nan, SW French, JA Bezerra, AS Gukovskaya, SJ Pandol. (2006) Pancreas
recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice.
Gastroenterology 131:885-899. PMID: 16952557
89.
L Fischer, AS Gukovskaya, JM Penninger, H Friess, I Gukovsky, SJ Pandol. (2007)
Phosphatidylinositol 3-kinase facilitates bile acid-induced calcium responses in pancreatic acinar
cells. Am J Physiol Gastrointest Liver Physiol 292:G875-G886. PMID: 17158252
90.
M Edderkaoui, PP Hong, JK Lee, SJ Pandol, AS Gukovskaya. (2007) Insulin-like growth
factor-I receptor mediates the pro-survival effect of fibronectin in pancreatic cancer cells. J Biol
Chem, 282:26646-26655. PMID: 17627944
91.
JK Lee, M Edderkaoui, P Truong, PP Hong, I Ohno, KT Jang, A Berti, SJ Pandol, AS
Gukovskaya. (2007) NADPH oxidase promotes pancreatic cancer cell survival through
inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology, 133:16371648. PMID: 17983808
92.
Z Rakonczay, Jr, P Hegyi, S Dosa, B Ivanyi, K Jarmay, G Biczo, Z Hracsko, IS Varga, E Karg,
J Kaszaki, A Varro, J Lonovics, I Boros, I Gukovsky, AS Gukovskaya, SJ Pandol, T Takacs.
(2008) A new severe acute necrotizing pancreatitis model induced by L-ornithine in rats. Crit
Care Med, 36:2117-2127. PMID: 18594222
93.
M Edderkaoui, I Odinokova, I Ohno, I Gukovsky, VL Go, SJ Pandol, AS Gukovskaya. (2008)
Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer
cells. World J Gastroenterol, 14:3672-3680. PMID: 18595134
94.
IV Odinokova, KF Sung, OA Mareninova, K Hermann, Y Evtodienko, A Andreyev, I Gukovsky,
AS Gukovskaya. (2009) Mechanisms regulating cytochrome c release in pancreatic
mitochondria. Gut, 58:431-42. (Editorial: ibid, 328-330). PMID: 18596195
95.
KF Sung, IV Odinokova, OA Mareninova, Z Rakonczay Jr, P Hegyi, SJ Pandol, I Gukovsky, AS
Gukovskaya. (2009) Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect
against necrosis in pancreatitis. Exp Cell Res, 315:1975-1989. PMID: 19331832
96.
OA Mareninova, K Hermann, SW French, MS O’Konski, SJ Pandol, P Webster, AH Erickson,
N Katunuma, FS Gorelick, I Gukovsky, AS Gukovskaya. (2009) Impaired autophagic flux
mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute
pancreatitis. J Clin Invest, 119:3340-3355. PMID: 19805911
97.
I Ohno, G Eibl, I Odinokova, M Edderkaoui, RD Damoiseaux, M Yazbec, R Abroll, WA
Goddard 3d, O Yokosuka, SJ Pandol, AS Gukovskaya. (2010) Rottlerin stimulates apoptosis
in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. Am J Physiol
Gastrointest Liver Physiol, 298:G63-G73. PMID: 19762431
98.
I Gukovsky and AS Gukovskaya. (2010) Impaired autophagy underlies key pathological
responses of acute pancreatitis. Autophagy, 6:248-249. PMID: 20215882
99.
Y Nakamura, JH Do, J Yuan, IV Odinokova, OA Mareninova, AS Gukovskaya, SJ Pandol.
(2010) Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol
Gastrointest Liver Physiol, 298:G92-G100. PMID: 19850968
Anna S. Gukovskaya, Ph.D.
Page 17
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100.
JV Gerasimenko, P Ferdek, L Fischer, AS Gukovskaya, SJ Pandol. (2010) Inhibitors of Bcl-2
family proteins deplete ER Ca(2+) stores in pancreatic acinar cells. Pflugers Archiv – Eur J
Physiol, DOI 10.1007/s00424-010-0859-4.
B. PEER-REVIEWED PAPERS – In Press
1.
SJ Pandol, A Lugea, OA Mareninova, D Smoot, FS Gorelick, A Gukovskaya, I Gukovsky.
Investigating the pathobiology of alcoholic pancreatitis. Alcohol Clin Exp Res, 2010.
2.
I Gukovsky, SJ Pandol, AS Gukovskaya. Organellar dysfunction in the pathogenesis of
pancreatitis. Antioxidants Redox Signaling, 2010.
C. PEER-REVIEWED PAPERS – Submitted
1.
M Edderkaoui, C Nitsche, L Zheng, SJ Pandol, I Gukovsky, AS Gukovskaya. NADPH oxidase
activation in pancreatic cancer cells is mediated through Akt-dependent upregulation of
p22phox. J Biol Chem.
2.
C Nitsche, M Edderkaoui, G Eibl, N Kasahara, P Grippo, J Mayerle, MM Lerch, AS
Gukovskaya. Growth factors and Nox4 NADPH oxidase downregulate PHLPP phosphatases
in pancreatic cancer cells to maintain active Akt: a tumor-suppressor role of PHLPP1 in
pancreatic ductal adenocarcinoma. Gastroenterology.
3.
H Takahashi, MC Chen, H Pham, JC King, J Park, DM Harris, HA Reber, OJ Hines, AS
Gukovskaya, VLW Go, G Eibl. Baicalein, a component of Scutellaria baicalensis, induces
apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells.
RESEARCH PAPERS – NON-PEER-REVIEWED
INVITED ARTICLES, BOOK CHAPTERS, ETC.
1.
AS Gukovskaya, VP Zinchenko, BI Khodorov. (1988) Ionic signals in lymphocyte activation.
In: Intracellular Signalling (P.G.Kostyuk, M.A.Ostrovsky, eds.), Nauka Publ. Moscow, pp.135144 (in Russian).
2.
VP Zinchenko, AS Gukovskaya, OV Degtyaryova, VE Tyushev, OA Lebedev. (1988)
Changes in the cytoplasmic pH and free Ca2+ concentration in Ehrlich ascites tumor cell under
the action of ATP. In: Intracellular Signaling (P.G.Kostyuk, M.A.Ostrovsky, eds.) Nauka Publ.,
Moscow, pp.159-165 (in Russian).
3.
AS Gukovskaya, VP Zinchenko. (1990) Mechanisms of receptor-mediated ionic signals in rat
thymocytes and Ehrlich ascites tumor cells, Soviet Scientific Reviews, Section D, Physicochemical Biology. Harwood Academic, London, vol.10, pt.1, pp.1-98.
Anna S. Gukovskaya, Ph.D.
Page 18
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4.
SJ Pandol, AS Gukovskaya, TD Bahnson, VE Dionne. (1994) Cellular mechanisms mediating
agonist-stimulated calcium influx in the pancreatic acinar cell, Annals NY Acad. Sci. 713:4148.
5.
SJ Pandol, AS Gukovskaya, TD Bahnson. (1995) Nitric oxide and cyclic GMP mediate
agonist-stimulated calcium influx in pancreatic acinar cell, Regulatory Peptide Letter 6: 39-42.
6.
SJ Pandol, I Gukovsky, A Satoh, A Lugea, AS Gukovskaya. (2003) Emerging concepts for the
mechanism of alcoholic pancreatitis from experimental models.
J Gastroenterology 38: 623-628.
6.
SJ Pandol, I Gukovsky, A Satoh, A Lugea, AS Gukovskaya. (2003) Animal and in vitro
models of alcoholic pancreatitis: role of cholecystokinin. Pancreas 27: 297-300.
7.
SJ Pandol, I Gukovsky, A Satoh, L Fischer, A Lugea, AS Gukovskaya. Molecular
mechanisms of pancreatitis. (2003) 11th International Conference on Ulcer Research-ICUR, p.
349.
8.
AS Gukovskaya, EC Vaquero, M Edderkaoui, SJ Pandol. “Survival signals in pancreatic
cancer.” (2003) 11th International Conference on Ulcer Research-ICUR, p. 345.
9.
SJ Pandol, A Satoh, L Fischer, O Mareninova, A Lugea, I Gukovsky, AS Gukovskaya. (2004)
Alcoholic pancreatitis: hijacked pancreatic signals. The Cell 36: 22-27.
10.
VL Go, AS Gukovskaya, SJ Pandol. (2005) Alcohol and pancreatic cancer. Alcohol 35:205211, 2005.
11.
SJ Pandol, M Edderkaoui, JK Lee, R Hu, A Lugea, J Sul, M Apte, EC Vaquero, I Ohno, I
Gukovsky, VL Go, AS Gukovskaya. (2006) Alcohol, Reactive Oxygen Species, Pancreatitis
and Pancreatic Cancer. Alcohol, Tobacco and Cancer (Eds. CH Cho, V Purohit). pp. 109-118.
12.
AS Gukovskaya, OA Mareninova, IV Odinokova, KF Sung, A Lugea, L Fisher, YL Wang, I
Gukovsky, SJ Pandol. (2006) Cell death in pancreatitis: Effects of alcohol. J Gastroenterology
Hepatology 21: S10-S13.
13.
SJ Pandol, A Lugea, AS Gukovskaya, I Gukovsky. (2008) Epidemiology and pathophysiology
of alcoholic chronic pancreatitis. In: The Pancreas: An Integrated Textbook of Basic Science,
Medicine and Surgery. 2nd edition. Editors: Beger HG, Büchler MW, Kozarek RA, Lerch MM,
Neoptolemos JP, Warshaw AL, Whitcomb DC, Shiratori K. Malden, MA, Wiley-Blackwell.
Chapter 39.
14.
IV Odinokova, KF Sung, OA Mareninova, K Hermann, I Gukovsky, AS Gukovskaya. (2008)
Mitochondrial mechanisms of death responses in pancreatitis. J Gastroenterology Hepatology,
23: S25-S30.
15.
R Mukherjee, DN Criddle, A Gukovskaya, S Pandol, OH Petersen, R Sutton (2008)
Mitochondrial injury in pancreatitis. Cell Calcium 44: 14-23.
16.
S Pandol, M Edderkaoui, I Gukovsky, A Lugea, A Gukovskaya. (2009) Desmoplasia of
pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol 7 (11, Suppl): S44-S47.
Anna S. Gukovskaya, Ph.D.
Page 19
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ABSTRACTS (selected; and work yet unpublished)
1.
AS Gukovskaya, VP Zinchenko, YV Evtodienko. (1987) Secondary messenger systems in
mitogenic stimulation of rat thymocytes. IX Joint Symposium of the GDR and USSR
Biochemical Societies "Metabolic Regulations at the Molecular and Cellular Levels", Iena,
GDR, Abstracts, pp.52-53.
2.
AS Gukovskaya. (1989) Mechanisms of ionic signals generated by mitogenic lectins in thymic
lymphocytes. XI International Lectin Conference (Interlec-11), Tarty University, Abstracts,
p.43.
3.
AS Gukovskaya, SJ Pandol. (1993) Nitric oxide regulates neurotransmitter induced cGMP
rise and Ca2+ influx in pancreatic acinar cells. Gastroenterology 104:A306.
4.
AS Gukovskaya, S Poucell-Hatton, TJ Fitzsimmons, PS Perkins, V Zaninovic, D Sandoval, R
Rutherford, SJ Pandol. (1994) Apoptosis in experimental pancreatitis. Gastroenterology
106:A295.
5.
IY Gukovsky, L Feng, AS Gukovskaya, SJ Pandol. (1996) The calcium-binding protein
neurocalcin is expressed in pancreas. Gastroenterology 110:A1076.
15.
AS Gukovskaya, IY Gukovsky, S Periskic, TA Blinman, V Zaninovic, SJ Pandol. (1997) Loss
of extracellular matrix contacts leads to NF-B activation, cytokine expression, and production
and apoptosis in pancreatic acinar cell. Gastroenterology 112:A446.
18
AS Gukoskaya, IY Gukovsky, V Zaninovic, DT Kira, SJ Pandol. (1998) Metalloproteinases
regulate signal transduction pathways triggered by extracellular matrix proteins.
Gastroenterology 114:A464.
19
IY Gukovsky, AS Gukovskaya, SJ Pandol. (1998) Cerulein activates NF-B and AP-1 in
pancreatic acinar cells. Gastroenterology 114:A465.
20
AS Gukovskaya, IY Gukovsky, M Mouria, SJ Pandol. (1999) Cerulein stimulates apoptosis in
pancreatic acinar cells. Gastroenterology 116:A1128.
21
V Zaninovic, AS Gukovskaya, E Bostandzhyan, VE Eysselein, SJ Pandol. (1999) Effect of
overexpression of transforming growth factor  on necrotizing cerulein pancreatitis in mice.
Gastroenterology 116:A1179.
22
IY Gukovsky, AS Gukovskaya, M Mouria, SJ Pandol. (1999) Detachment from extracellular
matrix stimulates NF-B activation and apoptosis in pancreatic cancer cells. Gastroenterology
116:A416.
23
AS Gukovskaya, I Gukovsky, M Mouria, SJ Pandol (1999) Regulation of pancreatic cancer
apoptosis by polyphenols. International Conference on Diet and Prevention of Cancer, Finland
Anna S. Gukovskaya, Ph.D.
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24
M Mouria, AS Gukovskaya, IY Gukovsky, SJ Pandol. (1999) Effects of polyphenols on
apoptosis and NF-B activation in pancreatic cancer cells. Gastroenterology 116:A470.
25
M Mouria, AS Gukovskaya, SJ Pandol. (2000) Mechanisms of the effects of food
polyphenolic compounds on apoptosis in pancreatic cancer cells. Gastroenterology 118:A538.
26
I Gukovsky, TA Blinman, M Mouria, V Zaninovic, E Livingston, SJ Pandol, AS Gukovskaya.
(2000) p38 MAP kinase is a key regulator of cytokine and chemokine expression in pancreatic
acinar cells. Gastroenterology 118:A157.
40.
I Gukovsky, C Reyes, V Zaninovic, F Wong, AS Gukovskaya, SJ Pandol. (2000)
Improvement of experimental pancreatitis with pharmacologic inhibitors of NF-B and AP-1
activation. Pancreas 21:446.
44.
A Lugea, AS Gukovskaya, I Gukovsky, JH Cheng, SJ Pandol. (2001) Fatty acid ethyl esters,
the non-oxidative ethanol metabolites, stimulate extracellular matrix protein production by
dispersed pancreatic acini: role of TGF-beta. Gastroenterology 120: A336.
45.
AS Gukovskaya, KJ Nam, E Vaquero, SJ Pandol. (2002) Polyphenols synergistically with
antioxidants stimulate apoptosis in pancreatic carcinoma cells. Gastroenterology 122: A493.
46.
AS Gukovskaya, JH Cheng, I Gukovsky, A Lugea, S Hosseini, SJ Pandol. (2002) Ethanol and
acetaldehyde decrease the activity of peroxisome proliferator-activated receptors (PPARs) in
pancreatic acinar cells. Gastroenterology 122:A283.
47.
AS Gukovskaya, KJ Nam, J Cheng, I Gukovsky, SJ Pandol. (2002) Phosphatidylinositol 3kinase mediates cholecystokinin induced calcium influx in pancreatic acinar cells.
Gastroenterology 122:A167.
48.
A Lugea, AS Gukovskaya, SJ Pandol. (2002) Ethanol metabolites alter extracellular matrix
(ECM) degradation and cell death pathways in rat pancreatic acinar cells. Gastroenterology
122:A167.
49.
S Hosseini, AS Gukovskaya, JH Cheng, I Gukovsky, SJ Pandol (2002) Ethanol has
differential effects on pathways mediating NF-kB activation in the pancreatic acinar cell.
Alcoholism Clinical and Experimental Research 26:59A.
50.
A Lugea, AS Gukovskaya, SJ Pandol. (2002) Inhibitory effect of non-oxidative ethanol
metabolites on the plasminogen system in rat pancreas. Pancreas 25:439.
51.
EC Vaquero, KJ Nam, I Gukovsky, SJ Pandol, AS Gukovskaya. (2002) Intracellular sources
of radical oxygen species (ROS) in human pancreatic cancer cells. Pancreas 25:455.
52.
I Gukovsky, KJ Nam, JH Cheng, SJ Pandol, AS Gukovskaya. (2003) Caspases and
poly(ADP-ribose) polymerase (PARP) regulate the balance between apoptosis and necrosis in
experimental pancreatitis. Gastroenterology 124:A502.
53.
MF Yazbeck, KJ Nam, EC Vaquero, AS Gukovskaya, SJ Pandol. (2003) The protein kinase C
delta inhibitor rottlerin greatly stimulates apoptosis in pancreatic cancer cells.
Gastroenterology 124:A103.
Anna S. Gukovskaya, Ph.D.
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Updated 2/17/2016
54.
I Gukovsky, JH Cheng, KJ Nam, OT Lee, A Lugea, JM Penninger, SJ Pandol, AS Gukovskaya.
(2003) Phosphatidylinositide 3-kinase (PI3K) gamma regulates key pathologic responses to CCK
in the pancreatic acinar cell. Gastroenterology 124:A500.
55.
EC Vaquero, KJ Nam, I Gukovsky, SJ Pandol, AS Gukovskaya. (2003) Non-mitochondrial
NAD(P)H oxidase mediates growth factor-induced ROS production and suppression of apoptosis
in pancreatic cancer cells. Gastroenterology 124:A290.
56.
SJ Pandol, I Gukovsky, A Satoh, A Lugea, AS Gukovskaya. Alcoholic pancreatitis: Insights
from animal models. (2004) International Society for Biomedical Research on Alcoholism, Falk
Symposium, Heidelberg, Germany.
57.
A Lugea, L Nan, SW French, JA Bezerra, AS Gukovskaya, SJ Pandol. (2004) Pancreas
tissue repair after cerulein-induced pancreatitis is impaired in plasminogen-deficient mice.
Gastroenterology 126:A104.
58.
A Satoh, MS Daghighian, JR Reeve Jr, SJ Pandol, AS Gukovskaya. (2004) TNF-α activates
proline-rich tyrosine kinase 2 (PYK2) in pancreatic acinar cells by protein kinase C dependent
mechanism. Gastroenterology 126:A529.
59.
A Satoh, AS Gukovskaya, MS Daghighian, JR Reeve Jr, SJ Pandol. (2004) Novel protein
kinase C isoforms delta and epsilon mediate cholecystokinin-induced activation of PYK2 and
NF-kB in pancreatic acinar cells by divergent pathways. Gastroenterology 126:A530.
60.
M Edderkaoui, EC Vaquero, PP Hong, MS Daghighian, SJ Pandol, AS Gukovskaya. (2004)
Reactive oxygen species mediate prosurvival effects of both extracellular matrix proteins and
growth factors in pancreatic cancer cells. Gastroenterology 126:A548.
61.
L Fischer, AS Gukovskaya, SH Young, P Buechler, MW Buchler, H Friess, SJ Pandol. (2004)
Phosphatidylinositide 3-kinase regulates hormone-induced calcium signals in pancreatic
acinar cells by inhibition of endoplasmic reticulum Ca2+-ATPase. Gastroenterology 126:A592.
62.
R Hu, Y-L Wang, PP Hong, M Edderkaoui, M Shahsahebi, A Zaninovic, A Lugea, MV Apte,
AS Gukovskaya, SJ Pandol. (2005) Pancreatic stellate cell NADPH oxidase system and its
regulation by ethanol and growth factors. Gastroenterology 128:A-631.
63.
A Lugea, FS Gorelick, AS Gukovskaya, SJ Pandol. (2005) Ethanol feeding induces a
protective endoplasmic reticulum stress response: regulation by cholecystokinin.
Gastroenterology 128:A-632.
64.
IV Odinokova, K-F Sung, YV Evtodienko, AS Gukovskaya. (2005) Pancreatic mitochondria
are highly susceptible to Ca2+ induced dysfunction. Gastroenterology 128:A-633.
65.
YL Wang, A Lugea, R Hu, OA Mareninova, D Smoot, AS Gukovskaya, Pandol SJ. (2005)
Ethanol feeding switches death pathway resulting in inhibition of apoptosis and promotion of
necrosis in pancreas. Gastroenterology 128:A-381.
66.
L Fischer, A Lugea, JM Penninger, B Vanhaesebroeck, MW Buchler, H Friess, AS
Gukovskaya, SJ Pandol, I Gukovsky. (2005) Diverse roles of class I PI3K isoforms δ and γ in
Anna S. Gukovskaya, Ph.D.
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Updated 2/17/2016
cerulein-induced pancreatitis: PI3K δ is necessary for trypsinogen activation. Pancreatology
5(Suppl 1):53-54.
67.
M Edderkaoui, P Hong, SJ Pandol, AS Gukovskaya. (2005) IGF-R mediates the fibronectininduced protection from apoptosis in pancreatic cancer cells. Pancreas 31:438-439.
68.
JK Lee, M Edderkaoui, P Hong, P Truong, JA Berti, SJ Pandol, AS Gukovskaya. (2005)
NADPH oxidase Nox4 mediates pancreatic cancer cell survival by activating JAK2 kinase.
Involvement of LMW-PTP protein tyrosine phosphatase. Pancreas 31:451-452.
69.
OA Mareninova, KF Sung, P Hong, A Lugea, SJ Pandol, I Gukovsky, AS Gukovskaya. (2005)
Caspases protect from necrosis and regulate the severity of cerulein pancreatitis. Pancreas
31:454.
70.
KF Sung, IV Odinokova, OA Mareninova, P Hong, A Lugea, A Hoffmann, I Gukovsky, SJ
Pandol, AS Gukovskaya. (2005) Bcl-xL is upregulated in different models of acute
pancreatitis and protects pancreas from cell death. Pancreas 31:472.
71.
JK Lee, M Edderkaoui, PP Hong, P Truong, JD Lambeth, A Berti, SJ Pandol, AS Gukovskaya.
(2006) Sustained Akt phosphorylation is required for anti-apoptotic effect of insulin-like growth
factor-I in pancreatic cancer cells: role of phosphatases. Gastroenterology 130: A260.
72.
M Edderkaoui, I Ohno, PP Hong, SJ Pandol, AS Gukovskaya. (2006) Trans-activation of IGFR by fibronectin protects from apoptosis in pancreatic cancer cells. Gastroenterology
130:A277.
73.
M Edderkaoui, I Ohno, SJ Pandol, AS Gukovskaya. (2006) Resveratrol and embelin increase
apoptosis and decrease proliferation in pancreatic cancer cells through regulation of IAPs.
Gastroenterology 130:A278.
74.
A Satoh, AS Gukovskaya, JR Reeve, Jr., I Gukovsky, SJ Pandol. (2006) Ethanol sensitizes
pancreatic acinar cells to NF-κB activation through activation of protein kinase C epsilon.
Gastroenterology 130:A59.
75.
OA Mareninova, A Lugea, IV Odinokova, H Tsukamoto, I Gukovsky, SJ Pandol, AS
Gukovskaya. (2006) Ethanol stimulates Akt phosphorylation in the pancreas through PTEN
oxidation: a predisposing factor in alcoholic pancreatitis? Gastroenterology 130:A384.
76.
IV Odinokova, OA Mareninova, KF Sung, YV Evtodienko, AS Gukovskaya. (2006) Dual effect
of Ca2+ on cytochrome c release from pancreatic mitochondria: role of ROS. Gastroenterology
130:A383.
77.
I Ohno, M Edderkaoui M, PB Truong, IV Odinocova, JK Lee, H Saisho, AS Gukovskaya, SJ
Pandol. (2006) Inhibition of Bcl-2/Bcl-xL proteins stimulate apoptosis and inhibit proliferation of
pancreatic cancer cells. Gastroenterology 130:A279.
78.
L Fischer, A Lugea, M Shahsahebi, B Vanhaesebroeck, JM Penninger, H Friess, AS
Gukovskaya, SJ Pandol, I Gukovsky. (2006) Diverse roles of class I PI3K isoforms  and  in
cerulein-induced pancreatitis. Gastroenterology 130:A72.
Anna S. Gukovskaya, Ph.D.
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Updated 2/17/2016
79.
L Fischer, AS Gukovskaya, JM Penninger, H Friess, I Gukovsky, SJ Pandol. (2006)
Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca2+ responses in pancreatic acinar
cells. Gastroenterology 130:A712.
80.
I Ohno, G Eibl, IV Odinokova, M Edderkaoui, M Yazbeck, SJ Pandol, AS Gukovskaya. (2006)
Rottlerin stimulates apoptosis in pancreatic cancer through inhibition of Bcl-xL. Pancreas
33:487.
81.
AS Gukovskaya. (2006) Supramaximal cholecystokinin stimulates apoptosis and necrosis in
pancreatic acinar cells: Role in pancreatitis. Regulatory Peptides 135:105-106.
82.
M Edderkaoui , SJ Pandol, AS Gukovskaya. (2006) Embelin regulates XIAP and survivin
levels through different mechanisms and induces pancreatic cancer cell death. Pancreas
33:458.
83.
OA Mareninova, A Lugea, IV Odinokova, H Tsukamoto, I Gukovsky, SJ Pandol, AS
Gukovskaya. (2006) Akt activation in alcoholic pancreatitis: role of PTEN. Pancreas 33:481.
84.
G Zhao, CN Reyes, K Hermann, OA Mareninova, KF Sung, AS Gukovskaya, A Hoffman, SJ
Pandol, I Gukovsky. (2007) Roles of individual NF-kB proteins in pathologic responses of
experimental acute pancreatitis. Gastroenterology 132:A116.
85.
JH Do, O Mareninova, A Paik, C Reyes, A Lugea, L Fischer, I Gukovsky, A Gukovskaya, SJ
Pandol. (2007) The inflammatory response of acute pancreatitis promotes necrosis through
effects on the PI3 kinase system. Gastroenterology 132:A250.
78.
OA Mareninova, K Hermann, SJ Pandol, SW French, FS Gorelick, I Gukovsky, AS Gukovskaya.
(2007) Interrelationship between autophagy and apoptosis in cerulein pancreatitis.
Gastroenterology 132:A250-A251.
79.
OA Mareninova, A Lugea, IV Odinokova, I Gukovsky, SJ Pandol, AS Gukovskaya. (2007)
Mechanisms of pancreatic Akt activation in cerulein pancreatitis and by ethanol feeding. Role of
PTEN. Gastroenterology 132:A251.
80.
IV Odinokova, OA Mareninova, K Hermann, YV Evtodienko, A Andreyev, AS Gukovskaya.
(2007) Ca2+ and ROS regulate mitochondrial mediators of acinar cell death in experimental
pancreatitis. Gastroenterology 132:A253.
81.
I Ohno, AS Gukovskaya, I Odinokova, SJ Pandol. (2007) Bcl-2/Bcl-XL mediate the proapoptotic
effects of ROS in pancreatic cancer cells. Gastroenterology 132:A250-A437.
82.
M Edderkaoui, I Ohno, I Gukovsky, SJ Pandol, AS Gukovskaya. (2007) Ellagic acid regulates
apoptosis and proliferation in pancreatic cancer cells through inhibition of NF-kB.
Gastroenterology 132:A723.
83.
G Zhao, CN Reyes, K Hermann, KF Sung, AS Gukovskaya, A Hoffman, SJ Pandol, I Gukovsky.
(2007) Genetic deletions of NF-kB proteins ameliorate cerulein-induced pancreatitis. Pancreas
35:438.
Anna S. Gukovskaya, Ph.D.
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84.
IV Odinokova, KF Sung, K Hermann, OA Mareninova, I Gukovsky, AS Gukovskaya. (2007) BclxL and Bcl-2 prosurvival proteins protect against necrosis in pancreatitis. Pancreas 35:438.
85.
Z Rakonczay Jr, G Biczó, S Dósa, B Iványi, R Sinervirta, L Alhonen, K Jármay, Z Hracskó, IS
Varga, T Takács, J Lonovics, A Varró, I Gukovsky, AS Gukovskaya, SJ Pandol, P Hegyi. (2008)
Characterization of L-ornithine-induced acute necrotizing pancreatitis in rats. Pancreatology, in
press.
86.
G Biczó, P Hegyi, S Dósa, S Berczi, B Iványi, T Takács, A Varró, I Gukovsky, AS Gukovskaya,
SJ Pandol, Z Rakonczay Jr. (2008) L-ornithine is involved in the pathogenesis of L-arginineinduced experimental acute pancreatitis. Pancreatology, in press.
87.
IV Odinokova, (2008) Pancreatology, in press.
88.
M Edderkaoui, CJ Nitsche, G Eibl, AS Gukovskaya. (2008) Role of different subunits of NADPH
oxidase activation in IGF-I-induced ROS production and pro-survival effect in pancreatic cancer
cells. Gastroenterology 134:A46.
89.
J Gerasimenko, IV Odinokova, KF Sung, OA Mareninova, MA Lee, L Fischer, SJ Pandol, AS
Gukovskaya. (2008) Pro-survival Bcl-2 proteins regulate Ca2+ transport in pancreatic acinar
cells. Gastroenterology 134:A127-128.
90.
OA Mareninova, K Hermann, SJ Pandol, P Webster, SW French, FS Gorelick, I Gukovsky, AS
Gukovskaya. (2008) Autophagy impairment mediates vacuolization and trypsinogen activation in
experimental pancreatitis. Gastroenterology 134:A428.
Anna S. Gukovskaya, Ph.D.
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