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Dr. Qamar Javed
Associate Professor
Department of Biochemistry
Quaid-i-Azam University
Islamabad
PERSONAL DETAILS
Residential address:
Tel. No:
House No. 296, Street No. 64, Sector I-8/3, Islamabad.
(Office): 9064-3016;
(Cell): 0300-553-6011
E-mail:
qamarjaved22@yahoo.com
ACADEMIC CAREER
PhD
1988
Biochemistry/Molecular Biology
University of Swansea (Wales), U.K.
MPhil
1983
Biochemistry
Quaid-i-Azam University, Islamabad.
MSc
1980
Biology
Quaid-i-Azam University, Islamabad.
POSITIONS HELD
Jan, 2008 - to date
Associate Professor of Biochemistry (TTS)
Quaid-i-Azam University, Islamabad
Nov, 2003- Dec, 2008
Associate Professor of Biochemistry
COMSATS Institute of Information Technology, Islamabad
Jan, 2003 - Oct, 2003
Assistant Professor of Biochemistry, National University of
Science and Technology (NUST), Rawalpindi
1997- 2002
Senior Post-doc. Research Associate, Cardiology Division
Leicester University, U.K.
1992-1997
Postdoctoral Research Fellow
University of Reading, U.K.
1989-1992
Postdoctoral Research Fellow,
University of Southampton, U.K.
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GRANT AWARDS
 Pakistan Science Foundation (2006)
(Active Scientist Research Award, 2006; Grant Award: 0.57 million rupees)
Ref: PSF/P&D/A. SC. (115).
Investigator: Dr. Qamar Javed
 Leicester Hospitals NHS Trust, U.K. (2002)
(Ref: Drug-eluting stents, 2002; Grant award: £ sterling 14,000)
Title: Drug-eluting stents inhibit coronary artery restenosis
Investigators: Dr A Gershlick and Dr. Qamar Javed
 Cordis, U.S.A. (2001)
(Ref: Polmer-coated stents, 2001; Grant award: £ sterling 11,000)
Title: Research on feasibility of coating polymer-coated stents
Investigators: Dr. Qamar Javed and Dr A Gershlick
 The British Heart Foundation, U.K. (2000)
(Ref: PG/2000111, 2000; Grant award: £ sterling 59,693)
Title: TNF- antibody and tyrphostin eluting stents to inhibit vascular smooth cell
proliferation
Investigators Dr. Qamar Javed and Dr A Gershlick
RESEARCH INTERESTS
(a) Regulation of cytokines expression in the human vascular tissue; the role of
inflammatory cytokines in the pathogenesis of cardiovascular disease.
(b) Cytokines Gene polymorphism in relation to cardiovascular disease.
(c) Local drug delivery using drug-eluting stents to limit restenosis in coronary artery; a
promising alternative to by-pass surgery in patients suffering from coronary heart disease.
(d) Regulation of gene expression in eukaryotic cells; Role of messenger ribonucleic
proteins in the regulation of gene expression.
(e) Regulation of the matricellular proteins during pathological changes in the heart
disease patients.
M.PHIL STUDENTS SUPERVISED
S. No.
1.
Name
Maryam Yousaf
Title
Prevalence of Cardiovascular Risk Factors
in Patients
Viva Date
07-03-09
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2.
Tamkina Zar
Study on cardiovascular Disease
20-08-09
3.
Insiyah Shabbir
Cross Sectional Comparison of Cardiovascular
Risk Factors
23-07-09
4.
Arshad Islam
Cardiovascular Risk Elements in the Asian
Population
17-08-09
5.
Asad Muhammad
Cardiovascular Diseases in Pakistani Population
20-08-09
PUBLICATIONS
Hussain S, Asghar M and Javed Q. Resistin gene promoter region polymorphism and the
risk of hypertrophic cardiomyopathy in patients. Translational Research 2010;155(3):142147.
Balighi K, Lajevardi V, Moeineddin F, Jelani M, Tamizifar B, Nikoo A, Javed Q,
Ahmad W, Parvaneh N. A novel deletion mutation in the human hairless (HR) gene in an
Iranian family with atrichia and papular lesions. Clinical and Experimental Dermatology
2009 Oct;34(7):e498-500
Swanson N, Hogrefe K, Javed Q, Gershlick AH. In vitro evaluation of vascular
endothelial growth factor (VEGF)-eluting stents. International Journal of Cardiology
2003 Dec;92(2-3):247-251.
Swanson N, Hogrefe K, Javed Q, Malik N, Gershlick AH. Vascular Endothelial Growth
Factor (VEGF)-Eluting Stents: In Vivo Effects on Thrombosis, Endothelialization and
Intimal Hyperplasia. Journal of Invasive Cardiology 2003 Dec;15(12):688-692.
Swanson N, Javed Q, Hogrefe K and Gershlick A. Human internal mammary artery
organ culture model of coronary stenting? A novel investigation of smooth muscle cell
response to drug-eluting stents. Clinical Science 2002;103(4):347-353.
Javed Q, Swanson N, Vohra H, Thurston H and Gershlick A. Tumor necrosis factoralpha eluting stents reduce vascular smooth muscle cell proliferation in saphenous vein
organ culture Experimental and Molecular Pathology 2002;73(2):104-11.
Javed Q, Spring EL, Gershlick AH and de Bono DP. Plasminogen activator and
plasminogen activator inhibitor gene expression in human saphenous vein organ culture.
Experimental and Molecular Pathology 2001;70(2):146-53.
Moiseeva EP, Javed Q, Spring EL and de Bono DP. Galactin 1 is involved in vascular
smooth muscle cell proliferation. Cardiovascular Research 2000;45:493-502
Javed Q, Leake DS and Weinberg PD. Quantitative immunohistochemical detection of
oxidised low density lipoprotein in the rabbit arterial wall. Experimental and Molecular
Pathology 1999;65:121-140.
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Forster BA, Javed Q. Leake DS and Weinberg PD. High-resolution mapping of the
frequency of lipid deposits in thoracic aortas from cholesterol-fed and heritable
hyperlipidaemic rabbits. Atherosclerosis 1996;120:249-253.
Fleming TP, Butler L, Lei X, Collins J, Javed Q, Sheth B, Stoddart N, Wild A. and Hay
M. Molecular maturation of cell adhesion systems during mouse early development.
Histochemistry 1994;101:1-7.
Fleming TP, Javed Q, Collins J, and Hay M. Biogenesis of structural intercellular
junctions during cleavage in the mouse embryo. Journal of Cell Science 1993;17: 119125.
Javed Q, Fleming TP, Hay M and Citi S. Tight junction protein cingulin is expressed by
maternal and embryonic genomes during early mouse development. Development
1993;117:1145-1151.
Fleming TP, Hay M., Javed Q and Citi S. Localisation of tight junction protein cingulin
is temporally and spatially regulated during early mouse development. Development
1993;117:1135-1144.
Fleming TP, Javed Q and Hay M. Epithelial differentiation and intercellular junction
formation in the mouse early embryo. Development Suppl 1992;105-112.
Javed Q, Newton RP and Ratcliffe NA. A novel plasma factor that potentate
prophenoloxidase activation in the immune response of Blaberus discoidalis. Biochemical
Society Transactions. 1990;18(3):457.
Javed Q and Merrett MJ. Mobilisation of NADPH glutamate dehydrogenase mRNA in
regreening cultures of Euglena gracilis. Plant Science 1987;49:31-36.
Javed Q and Merrett MJ. Properties and immunochemical characterisation of NADPHspecific glutamate dehydrogenase from Euglena gracilis. New Phytology 1986; 104:407413.
Fayyaz-Chaudhary M, Javed Q and Merrett MJ. Effect of growth conditions on NADPHspecific glutamate dehydrogenase activity of Euglena gracilis. New Phytology
1985;101:367-376.
Parker JE, Javed Q and Merrett MJ. Glutamate dehydrogenase (NADP-dependent)
mRNA in relation to enzyme synthesis in Euglena gracilis.
Evidence for posttranscriptional control. European Journal of Biochemistry
1985;153:573-578.
PUBLICATIONS FROM INTERNATIONAL CONFERENCES
Swanson N, Hogrefe K, Malik N, Javed Q and Gershlick A. Vascular endothelial growth
factor (VEGF) - eluting stents. In vivo assessment of effects on thrombosis,
endothelialisation and restenosis. British Cardiac Society Conference, Glasgow, U.K.,
2002.
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Swanson N, Javed Q, Hogrefe K, Gershlick A. Human arterial organ culture model of
drug-eluting stents to reduce restenosis. Abstract 173 accepted for British Cardiac Society
Conference, Glasgow, U.K., 2001.
Swanson N, Hogrefe K, Javed Q, Azrin MA and Gershlick AH. VEGF-eluting stents
stimulate endothelial cell growth in vitro. Journal of American College of Cardiology
2001;37(Suppl A):1A 1038-12.
Swanson NM, Javed Q, Hogrefe K and Gershlick AH. VEGF-eluting coronary stents
stimulate endothelial growth in vitro. Journal of Submicroscopic Cytology and Pathology
2000;32 (3) 419 B087.
Swanson N, Baron JH, Hogrefe K Javed Q and Gershlick AH. Novel delivery of vascular
endothelial growth factor delivery using polymer-coated stents: loading and elution
characteristics. British Cardiac Society Conference, Glasgow, U.K., 15-18 May 2000.
Heart 83 (Suppl 1 P28).
Swanson N, Hogrefe K, Baron J, Javed Q and Gershlick A. VEGF-eluting stents to
reduce stent complications – pharmacokinetics of adsorption and elution. 6th International
LDD&R Local Drug delivery meeting and cardiovascular course on Radiation &
Molecular Strategies – Abstract Book. January 2000.
N Swanson, K Hogrefe, Q Javed, AH Gershlick. Drug-eluting stents – could drugs
tailored to the patient be loaded in the catheter lab?
European Heart Journal 2000;21(Suppl) P1601
Javed Q, Spring EL, Gershlick AH and de Bono DP. Plasminogen activator and
Plasminogen activator inhibitor expression in vascular organ culture. European Heart
Journal 1999;20(Suppl):42 P410.
Moiseeva EP, Javed Q, Spring EL and de Bono DP. Galactin 1 modifies growth of
vascular smooth muscle cell. European Heart Journal 1999;20 (Suppl):64 P498.
Javed Q, Leake DS and Weinberg PD. Quantitative immunolocalisation of oxidised low
density lipoprotein in the rabbit aortic wall. Atherosclerosis (Suppl) 1995;115:15.
Fleming TP, Javed Q and Hay M. Epithelial junction maturation during early mouse
development. Joint Spring Meeting of British Society for Cell Biology and British Society
for Developmental Biology, University of Sussex, Brighton, 7-10 April, 1992.
Javed Q, Fleming TP and Hay M. Expression of tight junction protein cingulin during
early mouse development. The Seventh International Conference of the International
Society of Differentiation, Helsinki, Finland, 19-23 July, 1992.