9 th Annual Meeting OF The Institute OF Molecular Medicine Trinity Centre for Health Sciences at St. James’s Hospital 17 t h & 18 t h November 2006 INSTITUTE OF MOLECULAR MEDICINE Programme DAY 1 Friday 17th November 9.00 am Registration 9.30 am Opening of Meeting Prof Dermot Kelleher, Director of Institute of Molecular Medicine, Head of Department of Clinical Medicine, Head of School of Medicine, TCD and St James’s Hospital “Annual Review of the IMM - 2006” SESSION I Chair: Prof Mark Lawler, Institute of Molecular Medicine, TCD and St James’s Hospital 10.00 am 4th Institute of Molecular Medicine Lecture Prof Michael Gill Head of Department of Psychiatry, Institute of Molecular Medicine, TCD and St James’s Hospital “Functional Investigation of DNA Risk Variants for Psychiatric Disorders” 10.45 am Coffee Break SESSION II Chairs: Prof Noel Lowndes, Head of Biochemistry, NUI Galway and Dr Joseph Keane, Institute of Molecular Medicine, TCD and St James’s Hospital 11.15 am Dr Alan Irvine Consultant Dermatologist, Department of Clinical Medicine, TCD and Our Lady’s Hospital for Sick Children / St James’s Hospital “Filaggrin and Human Disease” 12.00 pm Dr David Dockrell Wellcome Trust Senior Lecturer, School of Medicine and Biomedical Sciences, University of Sheffield, UK “Live and Let Die: The Macrophages Response to Bacterial Pneumonia” 12.45 pm Dr Ross McManus Wellcome Trust Senior Lecturer, School of Medicine, Institute of Molecular Medicine, TCD “Inflammatory Bowel Disease – Xenophobia in the Gut?” INSTITUTE OF MOLECULAR MEDICINE Programme 13.15 pm LUNCH SESSION III Chairs: Prof Bill Powderly, Head of School of Medicine & Medical Science, UCD and Dr Padraic Fallon, Department of Clinical Medicine, Institute of Molecular Medicine, TCD 14.30 pm Dr Tom Ryan Institute of Molecular Medicine, TCD and St James’s Hospital “Sepsis and Infection” 15.15 pm Prof JoAnne Flynn Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburg, USA “The Mechanism of Tuberculosis Immunity – Lessons for Therapeutics Design and Safety” 16.00 pm Coffee Break 16.30 pm Dr Derek Nolan Department of Biochemistry, Wellcome Trust Senior Fellow, TCD “Innate Immunity and the Origin of East African Human Sleeping Sickness” 17.00 pm Dr Gilmore O’Neill Biogen Idec and Harvard University, USA “MS Treatment and PML – the Tysabri Story” SESSION IV Chair: ------------------------17.30 pm State of the Art Lecture Speaker to be Confirmed -------------------“Title to be confirmed” 18.15 pm RECEPTION INSTITUTE OF MOLECULAR MEDICINE Programme DAY 2 Saturday 18th November 9.00 am Registration SESSION V Chairs: Prof Brian Harvey, Head of Molecular Medicine, RCSI and Dr Orla Sheils, Institute of Molecular Medicine, TCD 9.30 am Prof John Reynolds Head of Department of Surgery, Institute of Molecular Medicine, TCD and St James’s Hospital “Oesophageal Cancer: Molecular Insights Into the Disease and Its Management” 10.00 am Speaker to be Confirmed “Title to be confirmed - SiRNA” 10.45 am Dr Judith Harmey Senior Lecturer, Department of Molecular and Cellular Therapeutics, RCSI “Protease Resistant Insulin-Like Growth Factor Binding Protein 4 is Anti-Angiogenic and Reduces Breast Tumour Growth” 11.15 am Coffee Break SESSION VI Chair: Prof Shaun McCann, Head of Haematology, Institute of Molecular Medicine, TCD and St James’s Hospital 11.45 am Dr Roger Preston Department of Haematology, Institute of Molecular Medicine, TCD & St James’s Hospital “Cross talk between Haemostasis and Inflammation through the Protein C Anticoagulant Pathway” 12.15 pm 7th Annual Durkan Lecture Prof Jane Apperley Head of Department of Haematology, Faculty of Medicine, Imperial College, UK “Long Term Complications of Stem Cell Transplantation” 1.00 pm End of Meeting