BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Hsiao, Chiu-Bin Assistant Professor of Medicine eRA COMMONS USER NAME CHSIAO EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION Taipei Medical University, Taipei, Taiwan (Taipei Medical College) Medical College of Ohio at Toledo, USA Medical Residency, University at Buffalo, SUNY, Buffalo, New York, USA Fellowship, University at Buffalo, SUNY, Buffalo, New York, USA DEGREE (if applicable) YEAR(s) FIELD OF STUDY M.D. 1984 Medicine MSBS 1993 1992 Microbiology Internal Medicine 1995 Infectious Diseases A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee. 1986-1993 Graduate Student, Research Assistant, Microbiology, Medical College of Ohio at Toledo (Medical University of Ohio at Toledo) 1989-1992 Medical Residency, Instructor, Internal Medicine, SUNY at Buffalo 1992-1995 Fellow, Infectious Diseases Division, Instructor, SUNY at Buffalo 1995-2000 Assistant Professor of Clinical Medicine, HIV Medicine and Infectious Diseases, Erie County Medical Center, Buffalo, New York. 2000-2001 Assistant Professor of Clinical Medicine, SUNY at Buffalo; Infectious Diseases Division, Buffalo General Hospital and Roswell Park Cancer Institute, Buffalo, New York 2002-2004 Assistant Professor of Medicine, SUNY at Buffalo; Infectious Diseases Division, Buffalo General Hospital and Roswell Park Cancer Institute, Buffalo, New York 2004Assistant Professor of Medicine, SUNY at Buffalo; Coordinator for HIV Research, Infectious Diseases/ HIV Medicine, Erie County Medical Center 2005Constant Member, Human Subject Committee, University at Buffalo, SUNY 2006 Visiting Professor, Fu-Dan University, Shanghai Public Health Center, China 2007-2009 Project Director: Nicholas A. Rango HIV Clinical Scholars Program/WNY (New York State Department of Health AIDS Institute) 2008Representative for Erie County Medical Center and Western New York: New York HIV Research Center Consortium Director Meeting 1988 & 1989 Honorable Mention Award, Annual Graduate Student Research Forum, MCO at Toledo 2001 Siegel Award for Excellence in Teaching, Medical School, University at Buffalo Professional Certification: 2002 HIV Specialist, Certified by American Academy of HIV Medicine, #NY1203B022 (Renew every 2 years, 2002-current) 1996 Infectious Diseases, Certified by American Board of Internal Medicine, #144544 (Re-certified 2006-2016) 1994 Internal Medicine, Certified by American Board of Internal Medicine, # 144544 (Re-certified 2004-2014) 1992 1990 1988 1984 New York State License # 189253 (NPI Number: 1699141170, ME Number: 244048400687) US Federal License Examination ECFMG, #381-807-7 Medical License, Taiwan, R.O.C. # 012771 B. Selected peer-reviewed publications (in chronological order). 1) Hsiao CB, Dryja D, Abbatessa L, Patel PH. Staphylococcus aureus Antimicrobial Susceptibility of Abscess Samples from Adults and Children from the Kaleida Health System in Western New York State, 2003-2006. J Clin Microbiol. 2010 “PMC Journal-In Process”. 2) Reynolds JL, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Agosto-Mujica A, Hsiao CB, Schwartz SA. Modulation of the proteome of peripheral blood mononuclear cells from HIV-1-infected patients by drugs of abuse. J Clin Immunol. 2009 Sep;29(5):646-56. Epub 2009 Jun 20.PMC 2828154 3) Ludwig LB, Ambrus JL Jr, Krawczyk KA, Sharma S, Brooks S, Hsiao CB, Schwartz SA. Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products. Retrovirology. 2006 Nov 8;3:80. PMC 1654176 4) Nair MP, Mahajan SD, Schwartz SA, Reynolds J, Whitney R, Bernstein Z, Chawda RP, Sykes D, Hewitt R, Hsiao CB Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients. J Immunol. 2005 Jun 1;174(11):6617-26. “PMC Journal-In Process”. 5) Dibo I, Pillai SK, Gold HS, Baer MR, Wetzler M, Slack JL, Hazamy PA, Ball D, Hsiao CB, McCarthy PL Jr, Segal BH. Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient. J Clin Microbiol. 2004 Apr;42(4):1843-5.PMC387622. 6) El-Solh AA, Hsiao CB, Goodnough S, Serghani J, Grant BJ. Predicting active pulmonary tuberculosis using an artificial neural network. Chest. 1999 Oct;116(4):968-73. “PMC Journal-In Process”. 7) Hewitt RG, Papandonatos GD, Shelton MJ, Hsiao CB, Harmon BJ, Kaczmarek SR, Amsterdam D. Prevention of disseminated Mycobacterium avium complex infection with reduced dose clarithromycin in patients with advanced HIV disease. AIDS. 1999 Jul 30;13(11):1367-72. “PMC Journal-In Process”. 8) Hsiao CB, Sethi S, Murphy TF. Outer membrane protein CD of Branhamella catarrhalis: sequence conservation in strains recovered from the human respiratory tract. Microb Pathog. 1995 Oct;19(4):215-25. “PMC Journal-In Process”. 9) Lehmann PF, Kemker BJ, Hsiao CB, Dev S. Isoenzyme biotypes of Candida species. J Clin Microbiol. 1989 Nov;27(11):2514-21.PMC 267069 10) Lehmann PF, Hsiao CB, Salkin IF. Protein and enzyme electrophoresis profiles of selected Candida species. J Clin Microbiol. 1989 Mar;27(3):400-4. PMC 267329 11) CB Hsiao 2008 A Practical Review – Diagnostic and Therapeutic Approaches for Managing Staphylococcus aureus Infection. European Infect Dis vol.2 issue 2, 2008 “PMC Journal-In Process”. 12) CB Hsiao 2006.How to Design a Simple, Safe and Highly Active Antiretroviral Regimen): in AIDS Medicine, 2nd Edition 2006, Taiwan. “PMC Journal-In Process”. 13) C.B Hsiao ( Editor) Chinese HIV Clinical Manual – www.antimicrobe.org 2009 “PMC Journal-In Process”. 14) Mahajan, S.D., Agosto-Mujica, A.A., Aalinkeel, R., Reynolds, J. L., Nair, B. B., Sykes, D. E., Martinez, J., Adams, J., Singh, N., Bernstein, Z., Hsiao, C., Schwartz, S. A. Effect of Polymorphisms in Chemokine and Chemokine receptors: Role in HIV-1 disease progression. Biochemical and Biophysical Research Communications 2010 ( In press) “PMC Journal-In Process”. C. Research Support. ACTIVE: 1) Investigator initiated Grant from Pfizer (# GA 400IN3) Mahajan SD (PI) Period 2/01/08-12/01/10 GRANT TITLE: Effect of the SDF-1 3’A Genetic variant on emergence of X4 tropism in Long Term Non-Progressors of HIV-1 disease. Description: The goal of this proposal is to evaluate the role of genetic polymorphism in the chemokine SDF-1 allele 3’A in the progression of HIV-1 disease. Role : Co-PI 2) RO1 LM009726-01 Schwartz SA (PI) Period- 6/01/09-5/31/12 Grant titled “ Integration of Clinical, Genomic and Proteomic Data In HIV-1 using a Bioinformatic approach. Description: The goal of this study is the integration of the clinical, genomic and proteomic data using innovative bioinformatic tools to yield a comprehensive database from which to predict patient outcomes and responses to therapy. Using new computational tools to analyze and integrate clinical and biological data, this translational research project will contribute to our fundamental understanding of the pathogenesis of HIV-1 infections and identify new biomarkers of disease progression. Role : Co-PI