11/2013
George P. Chrousos, MD
CURRICULUM VITAE
I.
Biographical Information
p. 2-3
II.
Academic Honors and Awards
p. 3-5
III.
Membership in Professional and Scientific Organizations
p. 6-
IV.
Membership in Committees - Editorial Boards - Society Boards
p. 6-8
V.
Publications
A. ORIGINAL ARTICLES
p.
8-57
B. CHAPTERS, REVIEWS, EDITORIALS
p. 57-91
C. BOOKS
p. 91-93
2
George P. Chrousos, M.D.
I.
BIOGRAPHICAL INFORMATION
NAME:
George P. Chrousos, M.D.
PRESENT ADDRESS:
Kyprou 2
Athens, Greece 15 452
DATE AND PLACE OF BIRTH:
July 18, 1951; Patras, Greece
CITIZENSHIP:
Greece, USA
DEGREES:
M.D., Athens University, Faculty of Medicine, Athens, Greece, 1975
Sc.D., Athens University, Athens, Greece, 1977
Doctor Honoris Causa, Liege University, Liege, Belgium, 2003
Doctor Honoris Causa, Universita Politechnica delle Marche, Ancona, Italy 2006
Doctor Honoris Causa, University of Patras, Patras, Greece 2011
CURRENT POSITIONS:
Professor and Chairman, First Department of Pediatrics and Head, Division of
Endocrinology, Metabolism and Diabetes (2001- ),
Athens University Medical School
UNESCO Chair on Adolescent Health Care (2010- )
FORMER POSITIONS HELD:
Senior Investigator
Developmental Endocrinology Branch (1981 - 1989)
National Institute of Child Health and Human
Development, NIH
Chief, Pediatric Endocrinology Section
Developmental Endocrinology Branch (1989 - 1999)
National Institute of Child Health and Human Development, NIH
Chief, Pediatric and Reproductive Endocrinology Branch (1999-2001),
National Institute of Child Health and Human Development, NIH
Senior Investigator (part-time) and Distinguished Visiting Scientist, Pediatric and
Reproductive Endocrinology Branch (2002-2004) and Reproductive Biology and
Medicine Branch (2005-2011), National Institute of Child Health and Human
Development, NIH
POSTGRADUATE TRAINING
1.
1975-1976
2.
1975-1976
3.
4.
1976-1978
1978-1981
1975-1980
Research Fellow, Laboratory of Microbiology and Immunology, Athens University,
Athens, Greece.
Resident, First Department of Internal Medicine, Athens University, Faculty of
Medicine, Athens, Greece.
Resident, Department of Pediatrics, New York University Medical Center, New York, NY.
Clinical Associate, Developmental Endocrinology Branch, National Institute of Child
Health and Human Development, NIH, Bethesda, Maryland.
CERTIFICATION AND LICENSURE
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George P. Chrousos, M.D.
1.
2.
3.
4.
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6.
7.
1975 License to practice Medicine in Athens, Greece
1975 Educational Council for Foreign Medical Graduates (ECFMG); Standard Certificate.
1977 Federation of State Licensure Examination (FLEX). License to practice in Massachusetts, Maryland,
Virginia and District of Columbia.
1980 American Board of Pediatrics
1980 American Board of Pediatric Endocrinology
1980 Greek Board of Pediatrics
1981 Greek Board of Endocrinology
ADMINISTRATIVE DUTIES
II.
•
Director, NICHD/Georgetown University ACGME-accredited Training Program in Pediatric
Endocrinology (1988-2002)
•
Chairman, Medicine and Physiology Department, Foundation for the Advanced Education in the
Sciences at the National Institutes of Health (1990-2002)
•
Chairman, Selection Committee and General Director, Biomedical Research Foundation (IIBEAA),
Academy of Athens, Athens, Greece (on sabbatical leave 2001-2002)
•
Director, Division of Maternal and Child Health, and Member, Board of Directors, Athens University
Medical School, Athens, Greece (2004-2005, 2007- 2009)
•
Director, Division of Endocrinology, Metabolism and Diabetes, Evgenidion Hospital, Athens
University Medical School, Athens, Greece (2005- date)
•
Senior Scientist and Director, Clinical Research Center, Biomedical Research Foundation of the
Academy of Athens (IIBEAA), Athens, Greece (2008-)
•
Director, Graduate Program on the Management of Stress and Health Promotion, Medical School,
University of Athens, Athens, Greece (2008-)
•
Director, Graduate Program on Pediatric and Nursing Research, Medical School, University of Athens,
Athens, Greece (2008-)
•
Director, A’ Sector of Medicine, Aghia Sophia Children’s Hospital, National Health Service (2009- )
•
Vice President, National Council on Research and Technology, Ministry of Education, Greece (20102013)
ACADEMIC HONORS AND AWARDS
1.
1969-1975
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3.
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5.
6.
1972-1975
1975
1977
1981-1983
1983-1985
1985-Date
1987 June
7.
1990-Date
"Scholarship of Excellence" awarded by the State Scholarship Institution, Ministry of
Education, Greek Government.
Scholarship "A. Papadakis", Athens University, Athens, Greece.
M.D. Degree summa cum laude, Athens, University, Faculty of Medicine, Athens, Greece.
Doctorate Diploma, "Excellent." Athens University, Athens, Greece.
Clinical Assistant Professor of Pediatrics
Clinical Associate Professor of Pediatrics
Clinical Professor of Pediatrics, Georgetown University Medical School, Washington, D.C.
The "Richard E. Weitzman Memorial Award," awarded by the U.S. Endocrine Society
"for outstanding research achievements in the fields of endocrinology and
metabolism".
Adjunct Professor of Physiology and Biophysics, Georgetown University Medical
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George P. Chrousos, M.D.
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9.
10.
11.
12.
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School, Washington, D.C.
Expert Testimony to 101st US Congress
The "Galen Award", Hellenic American Society for the Health Sciences, Washington, D.C.
Honorary Faculty, Keio University School of Medicine, Tokyo, Japan
Superior Service Award, U.S. Public Health Service, "for pioneering studies on the
regulation of hypothalamic-pituitary-adrenal axis function, leading to new insights into the
pathophysiology of adrenal diseases and novel diagnostic strategies".
1993 October Honorary Faculty, Parma University, Parma, Italy
1997 June
The 1997 Endocrine Society Clinical Investigator Award, “for major achievements in
clinical investigation”.
1997 July
The 1997 Hans Selye Award, Hans Selye Foundation, Montreal, Canada, “for
outstanding contributions to stress research.”
1999 June
First Prize, 1999 Pharmacia-Upjohn International Award for Excellence in Published
Clinical Research awarded by the US Endocrine Society.
1999 June
Professor of Pediatrics, Athens University Medical School (elected)
1999 October The 1999 Novera Herbert Spector Award, International Society for
Neuroimmunomodulation, Lugano, Switzerland “for significant contributions in both
leadership and research in neuroimmunomodulaton.”
1999 October Certificate of Commendation, American Academy of Pediatrics “for important
contributions made to the mission and goals of the Academy and to the
children.”
2000 Sept. The 2000 Henning Andersen Prize, European Society for Pediatric Endocrinology,
Brussels, Belgium
2000 Nov. Mastership Award, American College of Endocrinology, “for distinction as a role model
and as a contributor to the Art and Science of Endocrinology.”
2001 August Certificate of Recognition, Howard Hughes Medical Institute, Teachers and Students
Internship Program, Bethesda MD
2001 Nov
ISI Highly Cited Researcher in Clinical Medicine, ISI, Philadelphia, Pa.
www.ISIhighlycited.com
2001 Nov. Fellow, Japan Health Sciences Foundation, Tokyo, Japan
2002 April Clinical Endocrinology Trust Professor 2002, Sir Edward Sharpey-Schafer Medal,
British Endocrine Societies, for “major contributions to Endocrinology and
Metabolism”
2003 March Doctor Honoris Causa, University of Liege, Liege, Belgium
2004 July
Lifetime Achievement Award, International Society for Psycho-Neuro-Endocrinology,
Glasgow, UK for “outstanding scholarship and path-breaking contributions to
Psychoneuroendocrinology”.
2004 Dec
Distinguished Physician Award, Hellenic Medical Society of New York
2005 April
Mastership Award, American College of Physicians (MACP), “for significant contributions to
the Art and Science of Medicine”
2006 May
Doctor Honoris Causa, Universita Politechnica delle Marche, Ancona, Italy
2006 June
ISI Highly Cited Researcher in Biochemistry and Biology, ISI, Philadelphia, Pa.
www.ISIhighlycited.com
2006 Dec
The 2006 Gentle Giant Award, Pituitary Network Association, Rancho Mirage, Ca. “for
exceptional services above and beyond in the study of pituitary diseases”
2007 April The 2007 Henning Andersen Prize, European Society for Pediatric Endocrinology,
Helsinki, Finland
2007 June
Symposium on Cortisol Secretion Abnormalities Honoring Dr. George P. Chrousos
Horm Metab Res. 2007 Jun; 39(6): 401-3.
2007
Honorary Member, American Pediaric Society
2008 May 2008 Geoffrey Harris Prize in Neuroendocrinology, European Society of Endocrinology, Berlin,
Germany
2008 May
Honorary Fellow (FRCP), Royal College of Physicians, London, UK.
2008
Distinguished Visiting Scientist, NICHD, NIH, Bethesda, MD, USA
1990
1991 May
1991 July
1992 June
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George P. Chrousos, M.D.
38.
39.
41.
42.
2010
2010
2010
2010
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44.
45.
46.
2011
2011
2011
2011
47.
48.
49.
2011
2011
2012
50.
2013
Distinguished Visiting Professor, King Saud University, Riyadh, S. Arabia
UNESCO Chair on Adolescent Health Care
Member, Institute of Medicine, The National Academies, Washington, DC
Member, Academia Europaea (European Academy of Humanities, Letters and Sciences),
London, UK
Distinguished Adjunct Professor, King Abdulaziz University, Jeddah, KSA
John Kluge Chair on Technology and Society, The Library of Congress, Washington, DC
2011 Aristeion Bodossaki Prize, Bodossaki Foundation, Athens, Greece
UNICEF “Personality of the Year” award for “major contribution in the protection of the
human rights of children” by the UNICEF Greek National Committee
Doctor Honoris Causa, University of Patras, Patras, Greece
The Constantine Moiras Award, Academy of Athens, Athens, Greece
The 2012 Albert Struyvenberg Medal, The European Society of Clinical Investigation, Utrecht,
the Netherlands “for Excellence and Leadership in Translational and Multidisciplinary
Biomedical Research”.
Honorary Professor, University of Warwick, Coventry, UK
SELECTED NAMED LECTURES
1989 Beth Israel Seminar in Medicine, Harvard University Medical School, Boston, MA;
1989 Israel Macher Memorial Lecture, Albert Einstein College of Medicine, New York, NY;
1990 Christos Choremis Memorial Lecture, Hellenic Pediatric Society Annual Meeting, Thessaloniki,
Greece;
1991 Ira Rosenthal Lecture in Pediatrics, University of Illinois, Chicago, IL;
1994 Beth Israel Seminar in Medicine, Harvard University Medical School, Boston, MA;
1994 Millie Schembechler Memorial Conference on Adrenal Cancer, University of Michigan, Ann Arbor,
MI;
1995 Mark Dodge Memorial Lecture, University of Kansas and University of Missouri at Kansas City, MO;
1996 Robert Vine Memorial Lecture, Australasian Pediatric Endocrinology Group Annual Meeting,
Adelaide, Australia;
1997 Clinical Investigator Lecture, Endocrine Society, Minneapolis, MN;
1997 Hans Selye Memorial Lecture, International Congress of Stress, Budapest, Hungary;
1997 The J. Lester Gabrilove Lecture, Mount Sinai Medical School, New York, NY,
1998 The Novum Lecture, Karolinska Institute, Huddinge, Sweden,
1998 The 1998 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Athens, Greece.
1999 The 1999 Novera Herbert Spector Lecture, Fourth International Congress of the International Society
for Neuroimmunomodulation, Lugano, Switzerland.
1999 The 1999 Novartis Lecture, Canadian Society of Endocrinology and Metabolism, Ottawa, Canada
2000 The 2000 Nicholas Zervas Distinguished Lecture in Neuroendocrinology, Harvard University
Medical School, Boston, Massachusetts.
The 2001 George Merikas Memorial Lecture in Medicine, The University of Athens Medical School, Athens,
Greece
2001 Commencement Address, The University of Patras Medical School, Patras, Greece
2002 The 2002 Visiting Professor Lecture, British Endocrine Societies, Harrogate, England
2002 The 2002 Keith Harrison Memorial Lecture, The Endocrine Society of Australia, Adelaide, Australia
2003 The 2003 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Thessaloniki, Greece
2003. Distinguished Lecturer in Stress Biology, Children’s Hospital of Philadelphia, University of
Pennsylvania
2006. The 2006 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Athens, Greece
2007. Calouste Gulbenkian Foundation Lecture on “Stress, Inflammation and Well-being”, Lisbon, Portugal
2007. Megaron plus lecture on “Genes, Brain, Stress, and Evolution”, Athens, Greece
2008. The 2008 Goeffrey Harris Lecture, European Society of Endocrinology, Berlin, Germany
2008. The 2008 Karolinska Annual Clinical Science Lecture, Stockholm, Sweden
2009. The 2009 Mortimer B. Lipsett Memorial Lecture, NIH, Bethesda, Maryland
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George P. Chrousos, M.D.
2010 The 2010 Philip Hench Memorial Lecture, American College of Rheumatology, Atlanta, GA
2012 The 2012 Albert Struynvenberg Lecture, European Society of Clinical Investigation, Budapest,
Hungary
III. MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC ORGANIZATIONS
American Society for Clinical Investigation (Elected 1989)
Association of American Physicians (Inducted 1995)
The Society for Pediatric Research (Elected 1985)
The American Pediatric Society (Elected 1992)
The Endocrine Society
Lawson Wilkins Society for Pediatric Endocrinology
The Society for Neuroscience
American Federation for Clinical Research
American Academy of Pediatrics (Fellow)
American College of Physicians (Fellow, elected Master 2004)
New York Academy of Sciences
American Diabetes Association
International Brain Research Organization
International Society for Psychoneuroendocrinology
Molecular Medicine Society (Fellow)
European Society for Clinical Investigation (Elected 1995)
American College of Endocrinology (Fellow; Master, Elected 2000)
European Society for Pediatric Endocrinology (Corresponding Member, Elected 1997)
Association of Program Directors in Endocrinology and Metabolism (1998-2002)
Founding Member and Member of the Board, Association for Patient-Oriented Research (1999- 2002)
Fellow, The World Innovation Foundation (2004-)
Member of the Council, European Society for Clinical Investigation (2005-2008)
Member, MEDINE, Medical Education in Europe (2005-2007)
President, Hellenic Society of Pediatric and Adolescent Endocrinology (2006-)
President, Hellenic College of Pediatrics (2006-)
President, European Society for Clinical Investigation (2008-2011)
European Academy of Pediatrics (2009-)
Member of the Council, European Society of Pediatric Endocrinology (2012-)
Fellow, Mind and Life Institute, New York, NY (2012-)
IV. MEMBERSHIP IN COMMITTEES - EDITORIAL BOARDS-SOCIETY BOARDS
Medical Record Committee (Chairman), Clinical Center, NIH (1990-1997)
Pediatric Care Committee, Clinical Center, NIH
Clinical Research Review Board, NICHD, NIH
NIH Graduate Medical Education Committee
Memorial Endowment Committee, Mortimer B. Lipsett Memorial Fund, The Endocrine Society, Bethesda, Maryland
(1984)
Education Committee, The Endocrine Society, Bethesda, MD (1990-1993)
Editorial Board, Neuro-Endocrin-Immunology (1987-1990)
Editorial Board, Journal of Clinical Endocrinology and Metabolism (1992-1995)
Editorial Board, NeuroImmunoModulation (1993-2002)
Fogarty International Scholars Advisory Panel (1994-2000)
Editorial Board, Hellenic Medical Journal (1995-present)
Consultant, Task Force on SES and Health (1995) and Mind-Body Network (1997, 2001), John and Catherine
McArthur Foundation
Editorial Board, Endocrinology and Metabolism (1995-1998)
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George P. Chrousos, M.D.
Scientific Advisory Board, Institute for Hormone and Fertility Research, University of Hamburg, Germany (1995present)
Editorial Board, Stress (1995-present)
Board of Directors, Second World Congress on Stress, Melbourne, Australia 1998
Editorial Review Panel, "Panic, Anxiety, and Stress Disorders" (C.E. Koop, Chairman), Time Life Medical (19951997)
Editorial Board, Molecular Psychiatry (1995-present)
International Advisory Board, Arquivos Brasileiros de Endocrinologia e Metabologia (1996-present)
Editorial Board, Metabolism, Clinical and Experimental (1996-present)
Editorial Board, Endocrinology (1997- 2000)
Medical Advisory Board, Cushing's Support and Research Foundation, Inc. (1996-Present)
Public Health/Governmental Affairs Committee (Co-Chair), Pituitary Tumor Network Association (1995-Present)
Scientific Advisory Board (Co-Chair), National Adrenal Diseases Foundation, Inc. (1996-Present)
Practice Guidelines Subcommittee, American Academy of Asthma, Allergy and Immunology (1997)
Editorial Board, Endocrine (1997-)
Committee on Classification of Corticotropin-Releasing Factor Receptors, International Union of Pharmacology (NCIUPHAR) (1996-1998)
Basic and Clinical Endocrinology Interest Group at the National Institutes of Health, Co-Chair (1997- )
Advisory Council, Klinefelter Syndrome Association of Canada (1998- )
Editorial Board, Experimental and Clinical Rheumatology (1998- )
Editorial Board, Trends in Endocrinology and Metabolism (1998- )
Editorial Board, Iatriki (1998 - 2000)
Editorial Board, Journal of Clinical Endocrinology and Metabolism (1999 - 2002)
Board of Directors, International Society for the Investigation of Stress (1999- )
Editorial Board, Encyclopedia of Endocrine Disorders, Academic Press (1999- )
Editorial Board, Endocrine Practice (1999- )
Expert Consultant, Workgroup on Stress and Pre-Term Delivery, Centers for Disease Control, Atlanta, GA. (1999- )
National Aeronautics and Space Administration (NASA) Life Sciences Standing Panel, Chair (12/1/1999-11/30/2002)
Editorial Board, Current Drug Targets-Immune, Endocrine Metabolic Disorders (CDT-IEMD), (2000- )
Editor-in-Chief, On-line Textbook, Pediatric Endocrinology, www.eMedicine.com
Associate Editor, On-line Textbook, Endocrinology and Metabolism, www.endotext.org
Special Advisory Committee (Member), Endocrine Journal, The Japan Endocrine Society (2000- )
Editorial Board, Reviews in Endocrine and Metabolic Disorders (2000- )
Board of Directors, Pituitary Network Association (2000- )
Associate Editor, Hormones, Greek Endocrine Society (2001- )
Vice President, Hellenic Society of Pediatric and Adolescent Endocrinology (2001-2006)
President, International Society for NeuroImmunoModulation (2002-2005)
Editorial Board, Journal of Endocrinological Investigation (2002- )
International Board, The National Institute of Stress Evaluation and Management (2002- )
Editor-in-Chief, Neuroimmunomodulation (2002- 2006)
Endocrinology Consultant, Stedman’s Medical Dictionary (2002- )
Advisory Committee on Science and Technology, Greek Orthodox Archidiocese of America (2002- )
Consensus Statement, Congenital Adrenal Hyperplasia, Lawson Wilkins Pediatric Endocrine Society and European
Society for Pediatric Endocrinology, Boston (2002)
Board of Counselors, The Suffering Child (2003-) (www.thesufferingchild.net)
Consensus Statement on Cushing Syndrome (2002), International Symposium on Cushing Syndrome, Ancona, Italy
Consensus Statement on Adrenocortical Carcinoma (2003), International Schembechler Conference on Adrenocortical
Carcinoma, University of Michigan, Ann Arbor, Michigan
Scientific American, Greek Edition, Scientific Advisory Board (2003- )
Scientific Advisory Board, Research Center of Intensive and Thoracic Medicine, Athens, Greece (2003-)
Metabolism Network, Society for Women’s Health, Washington, DC (2003-)
Associate Editor, The Encyclopedia of Stress (2004-)
Associate Editor, Adolescent Gynecology, Reproduction and Menopause (2004- )
Editorial Board, American Journal of Medicine (2005-2011)
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George P. Chrousos, M.D.
Editorial Board, Gender Medicine (2005-)
Adrenal Insufficiency Task Force, American College of Critical Care Medicine (2005-2007)
Editorial Board, The Journal of Neuroendocrinology (2007-2012)
Consensus Statement on Use of LHRH Analogs (2008), Lawson Wilkins and ESPE, Milan, Italy
Consensus Statement on Use in Critical Illness-Related Cortisol Insufficiency (CIRCI) (2008), European Society
Critical and Intensive Care Medicine (ESCIM) and European Society of Endocrinology (ESE), Florence, Italy
Editorial Board, BMC Medicine, London, UK (2008- )
Editorial Board, Obesity Facts: The European Journal of Obesity, Basel, Switzerland (2008- )
Editorial Board, European Journal of Clinical Investigation, Ioannina, Greece (2009- )
Editorial Board, Journal of the Knowledge Economy, Springer, New York (2010- )
Editorial Board, Endocrine, Springer, New York, NY, USA
Editorial Board, Translational Psychiatry, Nature Group Publications, Canberra, Australia (2011-)
International Editorial Board, The American Journal of Medicine, USA (2011- )
Board of Directors, Seleni House Foundation, Inc, New York, NY, USA (2011-)
Reviewing Editor, Science Signaling, American Association for the Advancement of Science, USA (2012-)
Editorial Advisory Board, Nature Rev Endocrinol, Nature Publications, UK and USA (2012-)
Scientific Council, Maria Tsakos Foundation-International Center for Maritime Research and Tradition, NGO, Greece
(2012-)
Member of the Council, European Society of Pediatric Endocrinology (2012-)
Editorial Board, Steroids, Elsevier Publ. Co (2013-)
Editorial Board, Journal of Compassionate Health Care, BioMed Central (2013-)
VI. PUBLICATIONS
A.
ORIGINAL ARTICLES
1.
Musliner T., Chrousos G.P., Amos H. (1977) Transport Enhancement and Reversal:
Methylglucose. J. Cell. Physiology 91: 155-168.
2.
Chrousos G.P., Barnes K.M., Sauer M.A., Loriaux D.L., Cutler G.B. Jr. (1980) 1,9(11)-11-Deoxycortisol: An
Improved Antiglucocorticoid. Endocrinology 107: 472-477.
3.
Chrousos G.P., Loriaux D.L., Sherins R., Cutler G.B. Jr. (1981) Unilateral Testicular Enlargement Resulting from
Inapparent 21-Hydroxylase Deficiency. J. Urol. 126: 127-128.
4.
Chrousos G.P., Poplack D., Kostolich M., Wiede C., Oliff A., Brown T., Bercu B. (1981) HypothalamicAdenohypophyseal Function in the Rhesus Monkey: A Primate Model. J. Med. Primatol. 10(2): 61-71.
5.
Chrousos G.P., Wachsclicht-Rodbard H., Adams A., Roth J., Cornblath M. (1981) Increased
Binding in Hypoglycemic Infants and Children. Ped. Res. 15: 1345-1347.
6.
Wishnick M.M., Valenti Q., Doyle E.F., Balian A., Genieser N., Chrousos G.P. (1982) Churg-Strauss Syndrome:
Development of Cardiomyopathy during Corticosteroid Treatment. Am. J. Dis. Child. 136: 339-344.
7.
Chrousos G.P., Peck G., Gross E., Cutler G.B. Jr., Loriaux D.L. (1982) Adrenal Function in Women with Idiopathic
Acne, J. Invest. Dermatol. 78 (6): 468-471.
8.
Chrousos G.P., Loriaux D.L., Mann D., Cutler G.B. Jr. (1982) Late-onset 21-hydroxylase deficiency is an allelic
variant of congenital adrenal hyperplasia characterized by attenuated clinical expression and different HLA
haplotypes associates. Horm. Res. 16: 193-200.
9.
Chrousos G.P., Brown T., Bercu B. (1982) Pharmacologic Effects of Melatonin on HypothalamicAdenohypophyseal Function in the Nonhuman Primate. Neuroendocrinology 34: 343-346.
10.
Chrousos G.P., Renquist D., Brandon D., Barnard D., Fowler D., Loriaux D.L., Lipsett M.B. (1982) The Squirrel
Monkey: Receptor-mediated End-organ Resistance to Progesterone? J. Clin. Endocrinol. Metab. 55: 364-368.
Glucose and 3-0-
125
I- Insulin Specific
9
George P. Chrousos, M.D.
11.
Chrousos G.P., Renquist D., Brandon D., Eil C., Pugeat M., Vigersky R., Cutler G.B., Loriaux D.L., Lipsett M.B.
(1982) Glucocorticoid Resistance and Primate Evolution: Receptor-mediated Mechanisms. Proc. Natl. Acad. Sci.
179: 2036-2040.
12.
Chrousos G.P., Loriaux D.L., Mann D.L., Cutler G.B. Jr. (1982) Late-onset 21-Hydroxylase Deficiency Mimicking
Polycystic Ovarian Disease: An Allelic Variant of Congenital Virilizing Adrenal Hyperplasia with a Milder
Enzymatic Defect. Ann. In. Med. 96: 143-148.
13.
Chrousos G.P., Poplack D., Brown T., O'Neil D., Schwade J., Bercu B. (1982) Effects of Cranial Radiation on
Hypothalamic-Anterior Pituitary Function: Abnormal Growth Hormone Secretory Dynamics. J. Clin. Endocrinol.
Metab. 54: 1135-1139.
14.
Chrousos G.P., Vingerhoeds A., Brandon D., Pugeat M., Eil C., Loriaux D.L., Lipsett M.B. (1982) Primary Cortisol
Resistance in Man: A Glucocorticoid Receptor-mediated Disease. J. Clin. Invest. 69: 1261-1269.
15.
Cassorla F., Albertson B., Chrousos G.P., Booth J., Renquist D., Lipsett M.B., Loriaux D.L. (1982) The Mechanism
of Hypercortisolemia in the Squirrel Monkey. Endocrinology 111: 448-451.
16.
Schulte H.M., Chrousos G.P., Oldfield R., Gold P., Cutler G.B. Jr., Loriaux D.L. (1982) The effects of Corticotropin
Releasing Factor on the Anterior Pituitary Function of Stalk-Sectioned Cynomolgus Macaques. Dose Response of
Cortisol Secretion. J. Clin. Endocrinol. Metab. 55: 810-812.
17.
Schulte H.M., Chrousos G.P., Gold P., Philips J., Cutler G.B. Jr., Loriaux D.L. (1982) Metabolic Clearance Rate and
Plasma Half-life of Radioiodinated Corticotropin Releasing Factor in a Nonhuman Primate. J. Clin. Endocrinol.
Metab. 55: 1023-1025.
18.
Chrousos G.P., Sauer M.A., Cutler G.B. Jr., Loriaux D.L. (1982) 1-11-Oxa-11-deoxycortisol:
Antiglucocorticoid with Activity in vivo. Steroids 40: 425-431.
19.
Healy D.L., Hodgen G.D., Schulte H.M., Chrousos G.P., Loriaux D.L., Nicholas R.H., Goldstein H.L. (1983) The
Thymus-adrenal Connection: Thymosin Has Corticotropin Releasing Activity in Primates. Science 222: 1353-1355.
20.
Chrousos G.P., Vingerhoeds A.C.M., Loriaux D.L., Lipsett M.B. (1983) Primary Cortisol Resistance: A Family
Study. J. Clin. Endocrinol. Metab. 56: 1243-1245.
21.
Healy D.L., Chrousos G.P., Schulte H.M., Williams R.F., Baulieu E.E., Gold P.W., Hodgen G.D. (1983) Pituitary
and Adrenal Responses to the Anti-progesterone and Antiglucocorticoid Steroid RU 486 in Primates. J. Clin.
Endocrinol. Metab. 57: 863-865.
22.
Jacobowitz D.M., Schulte H.M., Chrousos G.P., Loriaux D.L. (1983) Localization of GRF-like Immunoreactive
Neurons in the Rat Brain. Peptides 4: 521-524.
23.
Pugeat M., Rocle B., Chrousos G.P., Dunn J., Lipsett M.B., Nisula B.C. (1984) Plasma Testosterone Transport and
Primate Evolution. J. Steroid Biochem. 20: 473-478.
24.
Schulte H.M., Chrousos G.P., Gold P.W., Oldfield E.H., Cutler G.B. Jr., Loriaux D.L. (1984) Corticotropin
Releasing Factor: Pharmacokinetics in Man. J. Clin. Endocrinol. Metab. 58: 192-196.
25.
Doppman J.L., Oldfield E.H., Krudy A.G., Chrousos G.P., Schulte H.M., Loriaux D.L., Schaaf M. (1984) Anatomic
and Technical Considerations of the Inferior Petrosal Sinus Sampling for Cushing's Disease. Radiology. 150: 999103.
26.
Almeida O.F.X., Schulte H.M., Rittmaster R.S., Chrousos G.P., Loriaux D.L., Merriam G.R. (1984) Potency and
Specificity of a Growth Releasing Factor in a Primate and in Vitro. J. Clin. Endocrinol. Metab. 58: 309-312.
27.
Chrousos G.P., Brandon D., Tomita M., Renquist D., Hogan W., Loriaux D.L., Lipsett M.B. (1984) Estrogen and
A New
10
George P. Chrousos, M.D.
Progesterone Receptors in a Progesterone "Resistant" New World Primate. J. Clin. Endocrinol. Metab. 58: 516-520.
28.
Chrousos G.P., Schulte H.M., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1984) The Corticotropin
Releasing Factor Stimulation Test: An Aid in the Differential Diagnosis of Cushing's Syndrome. N. Engl. J. Med.
310: 622-627.
29.
Schulte H.M., Chrousos G.P., Avgerinos P., Gold P.W., Oldfield E.H., Cutler G.B. Jr., Loriaux D.L. (1984) The
Corticotropin Releasing Factor Stimulation Test: a Possible Aid in the Evaluation of Adrenal Insufficiency. J. Clin.
Endocrinol. Metab. 58: 1064-1067.
30.
Chrousos G.P., Loriaux D.L., Brandon D., Hogan W., Renquist D., Johnson E., Lipsett M.B. (1984) Adaptation of
the Mineralocorticoid Target Tissues to the High Circulation Cortisol and Progesterone Plasma Levels in the
Squirrel Monkey. Endocrinology 115: 25-32.
31.
Pugeat M., Chrousos G.P., Nisula B., Loriaux D.L., Brandon D.D., Lipsett M.B. (1984) Plasma Cortisol Transport
and Primate Evolution. Endocrinology 115: 357-361.
32.
Rock J., Oldfield E.H., Schulte H.M., Gold P.W., Kornblith P.L., Loriaux D.L., Chrousos G.P., (1984)
Corticotropin Releasing Factor Administered into the Ventricular CSF Stimulates the Pituitary-adrenal Axis. Brain
Res. 323: 376-368.
33.
Crawley J.N., Ninan P.T., Pickar D., Chrousos G.P., Linnoila M., Scolnick, Paul S.M. (1984)
Neuropharmacological Antagonism of the beta-Carboline-induced "Anxiety" Response in Rhesus Monkeys. J.
Neuroscience 5: 477-485.
34.
Winterer J., Chrousos G.P., Cassorla F., Loriaux D.L. (1984) Acquired Refractoriness to Growth Hormone in a
Patient with Isolated Growth Hormone Deficiency: Growth Hormone and Plasma Somatomedin C Response to
High Dose Growth Hormone Therapy. J. Pediatrics, 104: 908-911.
35.
Schuermeyer T.H., Avgerinos P.C., Gold P.W., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1984) Human
Corticotropin Releasing Factor in Man. Pharmacokinetic Properties and Dose-response of Plasma ACTH and
Cortisol Secretion. J. Clin. Endocrinol. Metab. 59: 1103-1108.
36.
Udelsman R., Bacher J., Galluci W., Gold P.W., Morin M.L., Renquist D., Loriaux D.L., Chrousos G.P. (1984)
Hemodynamic and Endocrine Parameters in the Anesthetized Cynomolgus Monkey: A Primate Model. J. Med.
Primatol. 13: 327-337.
37.
Chrousos Antonakou G., Levine Ross J., Chrousos G.P., Chu F.C., Kenigsberg D., Cutler G.B. Jr., Loriaux D.L.
(1984) Ocular Findings in Turner Syndrome. A Prospective Study. Ophthalmology 91: 926-928.
38.
Tomita M., Chrousos G.P., Brandon D.D., Ben-Or S., Foster C., DeVougn L., Taylor S.J., Loriaux D.L., Lipsett
M.B. (1985) Glucocorticoid Receptors in Epstein-Barr Virus-transformed Human Lymphocytes. Hormone Metabol.
Res. 17: 674-678.
39.
Oldfield E.H., Chrousos G.P., Schulte H.M., Rock J.P., Poplack D.G., Gold P.W., Culter G.B. Jr., Kornblith P.L.,
Loriaux D.L. (1985) Active Clearance of Corticotropin-Releasing Factor from the Cerebrospinal Fluid.
Neuroendocrinology 40: 84-87.
40.
Evans M.I., Chrousos G.P., Mann D.L., Larsen J.W., McCluskey J., Green I., Loriaux D.L., Overpeck J., Fletcher J.,
Schulman J. (1985) Attempted Prevention of Abnormal Genital Masculinization in Suspected Congenital Adrenal
Hyperplasia by Adrenocortical Suppression in Utero. JAMA 253:1015- 1020.
41.
Schulte H.M., Chrousos G.P., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1985) Corticotropin
Releasing Factor Administration in Normal Men: Pituitary and Adrenal Responses in the Morning and Evening.
Horm. Res. 21: 69-74.
42.
Winterer J., Chrousos G.P., Loriaux D.L., Cutler G.B. Jr. (1985) The Adrenal Suppressive Effect of Hydrocortisone
11
George P. Chrousos, M.D.
in Congenital Adrenal Hyperplasia is not Affected by Varying the Dose Schedule. J. Pediatrics 106: 137-142.
43.
Schuermeyer T.H., Gold P.W., Galluci W.T., Tomai T.P., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1985)
Effects and Pharmacokinetic Properties of the rat/human Corticotropin Releasing Factor (r/h CRF) in Rhesus
Monkeys. Endocrinology 117: 300-306.
44.
Schutt-Aine J., Young M.A., Pescovitz O.H., Chrousos G.P., Marx S.J. (1985) Hypoparathyroidism: a Possible
Cause of Rickets. J. Pediatrics. 106: 255-259.
45.
Healy D.L., Chrousos G.P., Schulte H.M., Gold P.W., Hodgen G.D. (1985) Increased ACTH, Cortisol and Arginine
Vasopressin (AVP) Secretion Following the Antiglucocorticoid RU 486: Dose-response Relationships. J. Clin.
Endocrinol. Metab. 60: 1-4.
46.
Oldfield E.H., Chrousos G.P., Schulte H.M., Loriaux D.L., Schaaf M., Doppman J. (1985) Preoperative
Lateralization of ACTH Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Sinus
Sampling: N. Engl. J. Med. 312: 100-103.
47.
Rittmaster R.S., Cutler G.B. Jr., Sobel D.O., Koppelman M.C.S., Loriaux D.L., Chrousos G.P. (1985) Morphine
Inhibits the Pituitary-adrenal Response to Ovine Corticotropin Releasing Factor in Normal Subjects. J.Clin.
Endocrinol Metab 60: 891-895.
48.
Schuermeyer T.H., Tsokos G.C., Avgerinos P.C., Loriaux D.L., Balow J.E., Chrousos G.P. (1985) Pituitary-adrenal
Responsiveness to Corticotropin-releasing Hormone in Patients Receiving Chronic, Alternate-day Glucocorticoid
Therapy. J. Clin. Endocrinol. Metab. 61: 22-27.
49.
Schulte H.M., Chrousos G.P., Gold P.W., Booth J.D., Oldfield E.H., Culter G.B. Jr., Loriaux D.L. (1985)
Continuous Administration of Corticotropin Releasing Hormone in Normal Volunteers: Physiological and
Pathophysiological Implications. J. Clin. Invest. 75: 1781-1785.
50.
Susman E., Nottelman F., Inoff G., Dorn L., Loriaux D.L. Cutler G.B. Jr., Chrousos G.P. (1985) The Relation of
Hormonal Level and Physical Development and Social-emotional Behavior in Young Adolescents. J. Youth and
Adolescence. 14: 245-264.
51.
Rose S., Schulte H.M., Rauch A., White B., Hill S., Chandra R., Randolf J., Loriaux D.L., Chrousos G.P. (1985)
Testicular Dysgenesis and Mixed Gonadal Dysgenesis: Biochemical Characterization and Management of a Typical
Case. J. Ped. Endocrinol. 1: 123-128.
52.
Berrettini H.W., Nurnberger J., Gold P.W., Chretien M., Chrousos G.P., Chan J.S.D., Goldin L.R., Gerson E. (1985)
Neuropeptides in the Human Cerebrospinal Fluid. Life Sciences 37: 1265-1270.
53.
Udelsman R., Harwood J., Millan M., Chrousos G.P., Catt K.J., Aguilera G. (1985) Functional Receptors for
Corticotropin Releasing Factor in the Primate Peripheral Sympathetic System. Nature 319: 147-150.
54.
Berrettini W.H., Nurnberger J.I., Chan J.S., Chrousos G.P., Gaspar L., Gold P.W., Seidah N.G., Simmons-Alling S.,
Goldin L.R., Chretien M., Gershon E.S. (1985) Proopiomelanocortin-related Peptides in Cerebrospinal Fluid: A
Study of Manic Depressive Disorder. Psychiatry Res. 16: 287-302.
55.
Nieman L.K., Chrousos G.P., Kellner C., Spitz I., Nisula B., Cutler G.B. Jr., Merriam G.R., Bardin C.W., Loriaux
D.L. (1985) Successful Treatment of Cushing's Syndrome with the Glucocorticoid Antagonist RU 486. J. Clin.
Endocrinol. Metab. 61: 536-540.
56.
Gold P.W., Loriaux D.L., Roy A., Kling M.A., Calabrese J.R., Kellner C.H., Nieman L.K., Post R.M., Pickar D.,
Gallucci W., Avgerinos P., Paul S., Oldfield E.H., Cutler G.B. Jr., Chrousos G.P. (1986) Responses to Corticotropin
Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease: Pathophysiologic and Diagnostic
Implications. N. Engl. J. Med. 314: 1329-35.
57.
Rose S.R., Chrousos G.P., Cornblath M., Sidbury J. (1986) Oral Starch in the Management of Post- operative
12
George P. Chrousos, M.D.
Nesidioblastosis. J. Pediatrics 108: 97-100.
58.
Tomita M., Brandon D., Chrousos G.P., Vingerhoeds A.C.M., Foster C.M., Loriaux D.L., Lipsett M.B. (1986)
Characterization of Glucocorticoid Receptors from Epstein-Barr Virus-transformed Lymphocytes from
Glucocorticoid Resistant Patients and a New World Primate. J. Clin. Endocrinol. Metab. 62: 1145-1154.
59.
Weiss S.R.B., Post R.M., Gold P.W., Chrousos G.P., Sullivan T.L., Walker D., Pert A. (1986) CRF- induced
Seizures and Behavior: Interaction with Amygdala Kindling. Brain Res. 372: 345-351.
60.
Levine Ross J., Schulte H.M., Gallucci W.T., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1986) Ovine
Corticotropin Releasing Hormone Stimulation Test in Normal Children. J. Clin. Endocrinol. Metab. 62: 390-392.
61.
Schiebinger R., Chrousos G.P., Cutler G.B., Loriaux D.L. (1986) The Effect of Serum Prolactin on Plasma Adrenal
Androgens and the Production and Metabolic Clearance Rate of Dehydroepiandrosterone Sulfate in Normal and
Hyperprolactinemic Subjects. J. Clin. Endocrinol. Metab. 62: 202-209.
62.
Gold P.W., Gwirtzman H., Avgerinos P., Nieman L.K., Gallucci W.T., Kaye W., Jimerson D., Ebert M., Rittmaster
R., Loriaux D.L., Chrousos G.P. (1986) Abnormal Hypothalamic-pituitary-Adrenal Function in Anorexia Nervosa:
Pathophysiologic Mechanisms in Underweight and Weight-corrected Patients. N. Engl. J. Med. 314: 1335-42.
63.
Avgerinos P.C., Schuermeyer T., Gold P.W., Loriaux D.L., Cutler G.B. Jr., Chrousos G.P. (1986) Pulsatile
Administration of Human Corticotropin Releasing Hormone in Patients with Secondary Adrenal Insufficiency:
Restoration of the Normal Cortisol Secretory Pattern. J. Clin. Endocrinol. Metab. 62: 816-821.
64.
Rosner W., Pugeat M., Chrousos G.P., Khan M.S. (1986)
Endocrinology. 118: 513-517.
65.
Pavlov E.P., Harman M.S., Chrousos G.P., Loriaux D.L., Blackman M.R. (1986) Responses of Plasma
Adrenocorticotropin (ACTH), Cortisol, and Dehydroepiandrosterone to Ovine Corticotropin Releasing Hormone in
Healthy Aging Men. J. Clin. Endocrinol. Metab. 62: 767-772.
66.
Oldfield E.H., Schulte H.M., Chrousos G.P., Gold P.W., Benker G., Peterson R.E., Cutler G.B. Jr., Loriaux D.L.
(1986) Corticotropin Releasing Factor Stimulates ACTH Secretion in Nelson's Syndrome. J. Clin. Endocrinol.
Metab. 62: 1020-1026.
67.
Udelsman R., Gallucci W.T., Ramp J., Goldstein D.S., Lipford R., Norton J.A., Loriaux D.L., Chrousos G.P. (1986)
Adaptation during Surgical Stress: A Reevaluation of the Role of Glucocorticoids. J. Clin. Invest. 77: 1377-1381.
68.
Roy-Byrne P.P., Uhde T.W., Post R.M., Gallucci W., Chrousos G.P., Gold P.W. (1986) The CRH Stimulation Test
in Patients with Panic Disorder. Am. J. Psychiatry, 143: 396-399.
69.
Roy A., Gold P.W., Pickar D., Wolkowitz O.M., Chrousos G.P., Paul S.M. (1986) Pre- and Post- dexamethasone
Plasma ACTH Levels in Depressed Patients and Normal Controls. J. Affective Dis. 10: 95-99.
70.
Udelsman R., Bacher J., Gallucci P.W., Gold P.W., Renquist D., Loriaux D.L., Chrousos G.P. (1986)
Hemodynamic Effects of Human Corticotropin-releasing Factor (hCRF) in a Nonhuman Primate. Peptides 7: 465471.
71.
Munabi A., Feuillan P., Staton R., Rodbard D., Chrousos G.P., Anderson R.E., Strober M.D., Loriaux D.L., Cutler
G.B. Jr. (1986) Adrenal Steroid Responses to Continuous Intravenous ACTH Infusion Compared to Bolus
Injection. J. Clin. Endocrinol. Metab. 63: 1036-1040.
72.
Nieman L.K., Chrousos G.P., Oldfield E.H., Avgerinos P.C., Cutler G.B. Jr., Loriaux D.L. (1986) The Ovine CRH
Stimulation Test and the Dexamethasone Suppression Test in the Differential Diagnosis of Cushing's Syndrome.
Ann. Int. Med. 105: 862-867.
73.
A., Pickar D., Doran A., Wolkowitz O., Gallucci W., Chrousos G.P., Gold P.W. (1986) Normal ACTH and cortisol
Steroid Binding Proteins in Primate Plasma.
13
George P. Chrousos, M.D.
Responses to Corticotropin Releasing Hormone in Schizophrenia. Am. J. Psychiatry 143: 1393-1397.
74.
Saris S.C., Patronas N.J., Doppman J.L., Loriaux D.L., Cutler G.B. Jr., Nieman L.K., Chrousos G.P., Oldfield E.
(1986) Pituitary CT Scanning in Cushing's Syndrome. Radiology 162: 775-777.
75.
Doppman J.L., Oldfield E.H., Chrousos G.P., Nieman L.K., Udelsman R., Cutler G.B. Jr., Loriaux D.L. (1986)
Rebound Thymic Hyperplasia Following Treatment of Cushing's Syndrome. Am. J. Radiology 147: 1145-1147.
76.
Feuillan P., Poth M., Reilly W., Bright G., Loriaux D.L., Chrousos G.P. (1986) Ketokonazole Treatment of Type
Autoimmune Polyglandular Syndrome: Effects on Pituitary-adrenal Axis. J. Pediatrics, 109: 363-366.
77.
Nottelman E.D., Susman E.J., Dorn L.D., Inoff G.E., Loriaux D.L., Cutler G.B., Chrousos G.P. (1987)
Developmental Processes in Early Adolescence: Relations among Chronological Age, Pubertal Stage, Height,
Weight, and Serum Levels of Gonadotropins, Sex Steroids and Adrenal Androgens. J. Adol. Health Care 8: 35-48.
78.
Susman E., Inoff G., Nottelman E., Dorn L., Loriaux D.L., Chrousos G.P. (1987) Hormones, Emotional Disposition
and Aggression Attributes in Early Adolescents. Child Development 58: 1114-1134.
79.
Rittmaster R.S., Cutler G.B. Jr., Brandon D., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) The Effects of
Endogenous Vasopressin on ACTH and Cortisol Secretion in Man. J. Clin. Endocrinol. Metab. 64: 371-376.
80.
Laue L., Hoeg J.M., Barnes K., Loriaux D.L., Chrousos G.P. (1987) The Effect of Mevinolin on Steroidogenesis in
Patients with Defects in the LDL Receptor Pathway. J. Clin. Endocrinol. Metab. 64: 531-535.
81.
Kaye W.H., Gwirtsman H.E., George D.T., Ebert M., Jimerson D., Tomai T., Chrousos G.P., Gold P.W. (1987)
Elevated Cerebro-spinal Fluid Levels of Immunoreactive Corticotropin Releasing Hormone in Anorexia Nervosa:
Relation to State of Nutrition, Adrenal Function and Intensity of Depression. J. Clin. Endocrinol. Metab. 64: 203208.
82.
Nieman L.K., Choate T., Chrousos G.P., Healy D., Spitz I., Merriam G.R., Bardin C.W., Loriaux D.L. (1987)
Progesterone Antagonist RU 486: A Potential New Contraceptive Agent. N. Engl. J. Med. 316: 187-191.
83.
Nottelman E.D., Susman E.J., Dorn L.D., Inoff E.G., Loriaux D.L., Cutler G.B., Chrousos G.P. (1987)
Developmental Processes in American Early Adolescents: Relations Between Adolescent Adjustment and
Chronological Age, Pubertal Stage and Puberty-related Hormone Levels. J. Pediatrics 110: 473-480.
84.
Udelsman R., Norton J., Jelenich S., Goldstein D., Linehan W.M., Loriaux D.L., Chrousos G.P. (1987) Responses
of the Hypothalamic-pituitary-adrenal and Renin-angiotensin Axis and the sympathetic System during Controlled
Surgical and Anesthesia Stress. J. Clin. Endocrinol. Metab. 64: 986-994.
85.
Feuillan P., Stein C.A., LaRocca R., Lipford N., Raffeld M., Renquist D., Meyers C.E., Chrousos G.P. (1987)
Effects of Suramin on the Function and Structure of the Adrenal Cortex in the Cynomolgus Monkey. J. Clin.
Endocrinol. Metab. 65: 153-158.
86.
Kawai S., Nieman L.K., Brandon D.D., Udelsman R., Loriaux D.L., Chrousos G.P. (1987) Pharmacokinetic
Properties of the Antiglucocorticoid and Antiprogesterone Steroid of RU 486 in Man. J. Exp. Pharmacol. Ther. 241:
401-406.
87.
Luger A., Deuster P., Kyle S.B., Gallucci W.T., Montgomery L.C., Gold P.W., Loriaux D.L., Chrousos G.P. (1987)
Acute Hypothalamic-pituitary-adrenal Responses to the Stress of Treadmill Exercise: Physiologic Adaptations to
Physical Training. N. Engl. J. Med. 316: 1309-1315.
88.
Doppman J.L., Loughlin T., Miller D.L., Pass V.J., Chrousos G.P., Cutler G.B. Jr., Oldfield E.H., Loriaux D.L.
(1987) Identification of ACTH Producing Intrathoracic Tumors by Measuring ACTH Levels on Aspirated
Specimens. Radiology 163: 501-503.
89.
Risin Counts D., Hirsch Pescovitz O., Barnes K.M., Chrousos G.P., Sherins R.J., Comite F., Loriaux D.L., Cutler
14
George P. Chrousos, M.D.
G.B. (1987) Dissociation of Adrenarche and Gonadarche in Precocious Puberty and in Hypogonadotropic
Hypogonadism J. Clin. Endocrinol. Metab. 64: 1174-1178.
90.
Udelsman R., Goldstein D., Loriaux D.L., Chrousos G.P. (1987) Catecholamine-glucocorticoid Interactions during
Surgical Stress. J. Sur. Res. 43: 539-545.
91.
May C., Rapoport S.J., Cutler N.R., Chrousos G.P., Tomai T.P., Gold P.W. (1987) CSF Concentrations of
Corticotropin Releasing Hormone and Corticotropin Are Reduced in Patients with Alzheimer's Disease. Neurology
37: 535-538.
92.
Roy A., Pickar D., Linnoila M., Chrousos G.P., Gold P.W. (1987) Cerebrospinal Fluid Corticotropin Releasing
Hormone in Depression: Relationship to Noradrenergic Function. Psychiatry Res. 20: 229-237.
93.
Avgerinos P.C., Cutler G.B. Jr., Tsokos G.C., Gold P.W., Feuillan P., Gallucci W.T., Pillemer S.R., Loriaux D.L.,
Chrousos G.P. (1987) Dissociation between Cortisol and Adrenal Androgen Secretion in Patients Receiving
Alternate Day Prednisone Therapy. J. Clin. Endocrinol. Metab. 65: 24-29.
94.
Roy A., Pickar D., Paul S., Doran A., Chrousos G.P., Gold P.W (1987) CSF Corticotropin Releasing Hormone in
Depressed Patients and Normal Control Subjects. Am. J. Psychiatry 114: 641-645.
95.
Luger A., Calogero A., Kalogeras K., Gallucci W., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) Interaction of
Epidermal Growth Factor with the Hypothalamic-pituitary Adrenal Axis: Potential Physiologic Relevance. J. Clin.
Endocrinol. Metab. 66: 334-337.
96.
Laue L., Chrousos G.P., Loriaux D.L., Nieman L.K., Munson P., Schaison G. (1987) RU 486 Suppresses the
Plasma ACTH Response to Ovine Corticotropin-releasing Hormone. J. Clin. Endocrinol. Metab. 66: 290-293.
97.
Grino M., Chrousos G.P., Margioris A. (1987) The Corticotropin Releasing Factor Gene is Expressed in the Human
Term Placenta. Biol. Bioph. Res. Com 148: 1208-1214.
98.
Doppman J.L., Miller D.L., Dwyer A.J., Loughlin T., Nieman L., Cutler G.B., Chrousos G.P., Oldfield E., Loriaux
D.L. (1987) Macronodular Adrenal Hyperplasia in Cushing's Disease. Radiology 166: 347-352.
99.
Avgerinos P.C., Chrousos G.P., Nieman L.K., Oldfield E.H., Loriaux D.L., Cutler G.B. (1987) The Corticotropin
Releasing Hormone Test in the Postoperative Evaluation of Patients with Cushing's Syndrome. J. Clin. Endocrinol.
Metab. 65: 906-913.
100.
Balis F.M., Lester C.M., Chrousos G.P., Heideman R.L., Poplack D.G. (1987) Differences in Cerebrospinal Fluid
Penetration of Corticosteroids: Possible Relationship to Prevention of Meningeal Leukemia. J Clin Oncol 5: 202207.
101.
Berrettini W.H., Nurnberger J.I. Jr., Zerbe R.L., Gold P.W., Chrousos G.P., Tomai T. (1987) CSF Neuropeptides in
Euthymic Bipolar Patients and Controls. Br. J. Psychiatry 150:208-212.
102.
Roy A., Gallucci W., Linnoila M., Chrousos G.P., Gold P.W. (1988) The CRH Stimulation Test in Bereaved
Subjects with and without Accompanying Depression. Psych. Res. 25:145-156.
103.
Albertson B., Brandon D.D., Chrousos G.P., Loriaux D.L. (1988) Adrenal 11-Hydroxylase Activity in a
Hypercortisolemic New World Primate: Adaptive Intra-adrenal Changes. Steroids 49: 497-505.
104.
Inoff-Germain G., Snyder Arnold G., Nottelmann E.D., Susman E.J., Cutler G.B. Jr., Chrousos G.P. (1988)
Relations between Hormone Levels and Observational Measures of Aggressive Behavior of Young Adolescents in
Family Interactions. Dev. Psychol. 24: 129-139.
105.
Laue L., Hoeg J., Barnes K., Levine Ross J., Loriaux D.L., Chrousos G.P. (1988) Abnormal Growth Hormone
Secretory Dynamics in Children with Familial Hypercholesterolemia. Hormone Res. 938:1-6.
15
George P. Chrousos, M.D.
106.
Calogero A.E., Bernardini R., Gallucci W.T., Saoutis C., Gold P.W., Chrousos G.P. (1988) Cholinergic Stimulation
of Rat Hypothalamic Corticotropin Releasing Hormone in Vitro. Neuroendocrinology 47: 303-308.
107.
Giuffre K., Udelsman R., Listwak S., Chrousos G.P. (1988) Effects of Immune Neutralization of CRH, ACTH, and
Endorphin in the Surgically Stressed Rat. Endocrinology 122: 306-310.
108.
Feuillan P., Pang S., Avgerinos P., Schuermeyer T., Chrousos G.P. (1988) Adaptation of the Hypothalamicpituitary-adrenal Axis in Patients with Partial (Late-onset) 21-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab.
67: 154-160.
109.
Margioris A., Grino M., Protos P., Gold P.W., Chrousos G.P. (1988) Corticotropin Releasing Hormone and
Oxytocin Stimulate the Secretion of Immunoreactive alpha-MSH, beta-Endorphin and ACTH from the Human
Placenta In Vitro. J. Clin. Endocrinol. Metab. 66: 922-926.
110.
Laue L., Kawai S., Brandon D., Knazek R., Loriaux D.L., Chrousos G.P. (1988) Receptor-Mediated Effects of
Glucocorticoids on Inflammation: Enhancement of the Inflammatory Response with a Glucocorticoid Antagonist.
J. Steroid Biochem. 29: 591-598.
111.
Luger A., Deuster P., Kyle S.B., Gallucci W.T., Montgomery L.C., Loriaux D.L., Chrousos G.P. (1988) Reninangiotensin Responses during Treadmill Exercise. Hormone Res. 30: 5-9.
112.
Laue, L., Gallucci, W., Loriaux, D.L., Udelsman, R., Chrousos G.P. (1988) The Antiglucocorticoid and
Antiprogestin Steroid RU 486: Its Glucocorticoid Agonist Effect is Inadequate to Prevent Adrenal Insufficiency in
Primates. J. Clin. Endocrinol Metab. 67: 602-606.
113.
Calogero A.E., Gallucci W.T., Chrousos G.P., Gold P.W. (1988) Interaction between Gabaergic Neurotransmission
and Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro. Brain Res. 463: 28-36.
114.
Calogero A.E., Gallucci W.T., Chrousos G.P., Gold P.W. (1988) Effect of the Catecholamines Upon Rat
Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro: Clinical Implications. J. Clin. Invest. 82: 839846.
115.
Calogero A., Gallucci W.T., Gold P.W., Chrousos G.P. (1988) Multiple Regulatory Feedback Loops on
Hypothalamic Corticotropin Releasing Hormone Secretion. J. Clin. Invest. 82: 767-774.
116.
Doppman J.L., Frank J.A., Dwyer A.J., Oldfield E.H., Miller D.L., Nieman L.K., Chrousos G.P., Cutler G.B. Jr.,
Loriaux D.L. (1988) Gadolinium DPTA Enhanced MR Imaging of ACTH-Secreting Microadenomas of the
Pituitary Gland. J. Comp. Assist. Tom. 12: 728-735.
117.
Laue L., Peacock J., Gallucci W.T., Brandon D.D., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P., Norton J.A. (1988)
Glucocorticoid Receptor-mediated Effects on Rat Fibrosarcoma Growth. Cancer Res. 48: 2703-2706.
118.
Deuster P., Chrousos G.P., Luger A., Kyle S.B., Gallucci W.T., Montgomery L.C., Loriaux D.L. (1989)
Sympathetic System Responses to the Stress of Treadmill Exercise. Physiologic Adaptations to Physical Training.
Metabolism 38: 141-148.
119.
Calogero A.E., Bernardini R., Margioris A.N., Gallucci W.T., Munson P.J., Tamarkin L., Tomai T.P., Brody L.,
Gold P.W., Chrousos G.P. (1989) Serotonin Stimulates Rat Hypothalamic Corticotropin Releasing Hormone
Secretion In Vitro. Peptides 10: 189-210.
120.
Kawai S., Brandon D., Loriaux D.L., Chrousos G.P. (1989) Interaction of RU 486, A Glucocorticoid and
Progesterone Antagonist, with Human Circulating Mononuclear Leukocytes. Am. J. Med. Sci. 296: 167-171.
121.
Friedman R.B., Oldfield E.H., Nieman L.K., Chrousos G.P., Doppman J.L., Cutler G.B. Jr., Loriaux D.L. (1989)
Repeat Transsphenoidal Surgery in Cushing's Disease. J. Neurosurg. 71: 520-527.
122.
Margioris A., Koukoulis G., Grino M., Chrousos G.P. (1989) In Vitro Perifused Rat Testis Fragments Secrete beta-
16
George P. Chrousos, M.D.
Endorphin and Dynorphin: Effect of Opioids on Testosterone Secretion. Biol. Reprod. 40: 776-784.
123.
Perry R.R., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Loriaux D.L., Doppman J.L., Travis W.D., Norton J.A.
(1989) Primary Adrenal Causes of Cushing's Syndrome: Diagnosis and Surgical Management. Ann. Surg. 210: 5968.
124.
Sternberg E., Hill J.M., Chrousos G.P., Kamilaris T., Listwak S., Gold P.W., Wilder R.L. (1989) Inflammatory
mediator-induced Hypothalamic-pituitary-adrenal Axis Activation is Defective in Streptococcal Cell Wall Arthritis susceptible Lewis Rats. Proc. Natl. Acad. Sci. USA 86: 2374-2378.
125.
Gomez M.T., Chrousos G.P. (1989) Periodic Cushing's Syndrome in a Short Boy: Usefulness of the Ovine CRH
Test. J. Pediatr. 115: 270-273.
126.
Linder B., Feuillan P., Chrousos G.P. (1989) Alternate-day Prednisone Therapy in Congenital Adrenal Hyperplasia:
Adrenal Androgen Suppression and Normal Growth. J Clin. Endocrinol. Metab. 69:91-195.
127.
Bagdy G., Calogero A., Chrousos G.P., Szemeredi K. (1989) Delayed Effects of Chronic Cortisol Treatment on
Brain and Plasma Concentrations of Corticotropin (ACTH) and beta-Endorphin. Brain Res. 489: 216-222.
128.
Sternberg E.M., Young W.S. Jr., Bernardini R., Calogero A., Chrousos G.P., Gold P.W., Wilder R.L. (1989) A
Central Nervous Defect in the Stress Response is Associated with Susceptibility to Streptococcal Cell Wall Arthritis
in Lewis Rats. Proc. Natl. Acad. Sci. 86: 4771-4775.
129.
Bernardini R., Chiarenza A., Calogero A.E., Gold P.W., Chrousos G.P. (1989) Arachidonic Acid Metabolites
Modulate Rat Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro. Neuroendocrinology 50: 708-715
130.
Bernardini R., Calogero A.E., Ehlich Y.H., Brucke T., Chrousos G.P., Gold P.W. (1989). The Alkyl- ether
Phospholipid Platelet-activating Factor is a Stimulator of the Hypothalamic-pituitary-adrenal Axis in the Rat.
Endocrinology 125: 1067-1073.
131.
Calogero A., Gallucci W.T., Chrousos G.P., Gold P.W. (1989) Cocaine Stimulates Rat Hypothalamic Corticotropin
Releasing Hormone Secretion in Vitro. Brain Res. 505: 7-11.
132.
Doppman J.L., Pass H.I. Nieman L., Cutler G.B. Jr., Chrousos G.P., Loriaux D.L. (1989) Failure of Bronchial
Lavage to Select Elevated Levels of ACTH in Patients with ACTH-Producing Bronchial Carcinoids. J. Clin.
Endocrinol. Metab. 69: 1302-1304.
133.
Travis W.D., Tsokos M., Doppman J.L., Nieman L., Chrousos G.P., Cutler G.B., Loriaux D.L., Norton J.A. (1989)
Primary Pigmented Nodular Adrenocortical Disease: A Light and Electron Microscopic Study of Eight Cases. Am.
J. Surg. Pathol. 13: 921-930.
134.
Calogero A., Kamilaris T., Gomez M.T., Johnson E.O., Tartaglia E., Gold P.W., Chrousos G.P. (1989) The
Muscarinic Cholinergic Agonist Arecoline Stimulates the Rat Hypothalamic-pituitary-adrenal Axis Through a
Centrally-mediated Corticotropin-releasing Hormone Mechanism. Endocrinology 125: 2445-2453.
135.
Doppman J.L., Travis W.D., Nieman L.K., Miller D.L., Pass H.I., Chang R., Cutler G.B. Jr., Chrousos G.P., Norton
J.A., Ziessman H.A., Oldfield E.H., Loriaux D.L.v(1989) Cushing's Syndrome Due to Primary Pigmented Nodular
Adrenocortical Disease: Findings at CT and MR Imaging. Radiology 172(2):415-420.
136.
Doppman J.L., Nieman L.K., Miller D.L., Pass H.I., Chung R., Cutler G., Schauf M., Chrousos G.P., Norton J.A.,
Zirrsman H.A., Oldfield E.H., Loriaux D.L. (1989) Ectopic Adrenocorticotropin Hormone Syndrome: Localization
Studies in 28 Patients. Radiology 172: 115-124.
137.
Nieman L.K., Cutler G.B. Jr., Oldfield E.O., Loriaux D.L., Chrousos G.P. (1989) The Ovine Corticotropin
Releasing Hormone Stimulation Test is Superior to the Human Corticotropin Releasing Hormone Test for the
Detection of Cushing's Disease. J. Clin. Endocrinol. Metab. 69: 165-169.
17
George P. Chrousos, M.D.
138.
Marx S.J., Jones G., Weinstein R.J., Chrousos G.P., Renquist D. (1989) Vitamin D and Mineral Metalbolism in New
World and Old World Primates: A Novel State with Hyperphosphatetic Osteomalacia in Aotus trivirgatus. J. Olin.
Endocrinol. Metab. 69:1282-1290
139.
Pass H.I., Doppman J.L., Nieman L., Stovroff M., Veto J., Norton J.A., Travis W., Chrousos G.P., Cutler G.B. Jr.
(1990) Management of the Ectopic ACTH Syndrome Due to Thoracic Carcinoids. Ann Thorac-Surg 50: 52-57.
140.
Calogero A., Kling M.A., Gallucci W.T., Bernardini R., Chrousos G.P. and P.W. Gold (1990) Procaine and
Lidocaine Stimulate Corticotropin Releasing hormone Secretion by Explanted Rat Hypothalami through a Sodium
Conductance Independent Mechanism. Horm. Metab. Res. 22: 1-4.
141.
Dorn L., Susman E.J., Nottelmann E.D., Inoff-Germain G., Chrousos G.P. (1990) Perceptions of Puberty:
Adolescent, Parent, and Health Care Personnel Ratings of Pubertal Stage. Develop. Psych. 26: 322-329.
142.
Gazdar A.F., LaRocca R.V., Chen T.R., Triche T.J., Myers C.E., Chrousos G.P., Brennan M.R., Stein C.A., Oie
H.K. (1990) Establishment and Characterization of a Human Adrenocortical Carcinoma Cell Line That Expresses
Multiple Pathways of Steroid Biosynthesis. Cancer Res. 50: 5488-5496.
143.
Rabin D., Johnson E., Brandon D., Liapi C., Chrousos G.P. (1990) Glucocorticoids Inhibit Estradiol- induced
Uterine Growth: Possible Role of Estrogen Receptors. Biol. Reprod. 42: 74-80.
144.
Calogero A.E., Kamilaris T.C., Bernardini R., Johnson E.O., Chrousos G.P., Gold P.W. (1990) Relevance of the
"Peripheral" Benzodiazepine Receptor System to Hypothalamic pituitary-adrenal Function: Physiological and
Clinical Implications. J. Pharmacol Exp. Therap. 253: 729-737.
145.
Margioris A., Brockmann G., Bohler H., Grino M., Vamvakopoulos N., Chrousos G.P. (1990) Expression and
Localization of Growth Hormone - Releasing Hormone mRNA in Rat Placenta: In Vitro Secretion and Regulation
of Its Peptide Product. Endocrinology 126: 151-158.
146.
Malozowski S., Muzzo S., Burrows R., Leiva L., Loriaux L., Chrousos G.P., Winterer J., Cassorla F. (1990) The
Hypothalamic-pituitary-adrenal Axis in Infantile Malnutrition. Clin. Endocrinol. 32:461-465.
147.
Calogero A.E., Bagdy G., Szemereti, Tartaglia M.E., Gold P.W., Chrousos G.P. (1990) Mechanisms of Serotonin
Agonist-induced Activation of the Hypothalamic-pituitary-adrenal Axis in the Rat. Endocrinology 126: 1888-1894.
148.
Margioris A.N., Brockmann G., Kalogeras K., Fjellestad-Paulsen A., Stratakis C.A., Vamvakopoulos N., Chrousos
G.P. (1990) Effect of Hypertonic Saline Infusion on the Levels of Immunoreactive Dynorphin in Extracted Human
Plasma. J. Clin. Endocrinol. Metab. 71: 298-304.
149.
Bernardini R., Kamilaris T.C., Calogero A.E., Johnson E.O., Gold P.W., Chrousos G.P. (1990) Interactions
Between Tumor Necrosis Factor-, Hypothalamic Corticotropin-Releasing Hormone and Adrenocorticotropin
Secretion in the Rat. Endocrinology 126: 2876-81.
150.
Calogero A., Kamilaris T., Johnson E.O., Tartaglia M., Chrousos G.P. (1990) Recovery of the Rat Hypothalamicpituitary-adrenal Axis after Prolonged Treatment with Dexamethasone. Endocrinology 127: 1574-1579.
151.
Vamvakopoulos N., Karl M., Mayol V., Margioris A., Chrousos G.P. (1990) Structural Analysis of the Regulatory
Region of the Human Corticotropin Releasing Hormone Gene. FEBS Lett 267:1-5.
152.
Kalogeras K.T., Calogero A.E., Kuribayashi T., Khan I., Gallucci W.T., Kling M.A., Chrousos G.P., Gold P.W.
(1990) In vitro and In vivo Effects of the Triazolobenzodiazepine Alprazolam on Hypothalamic-pituitary-adrenal
Function: Pharmacologic and Clinical Implications. J Clin Endocrinol Metab, 70: 1462-1471.
153.
Rabin D., Schmidt P., Campbell G., Gold P.W., Jensvold M., Rubinow D., Chrousos G.P. (1990) Hypothalamicpituitary-adrenal Function in Patients with the Premenstrual Syndrome. J. Clin. Endocrinol. Metab. 71: 1158-1162.
154.
Doherty J.M., Nieman L.K., Cutler G.B., Chrousos G.P., Norton J. (1990) Time to Recovery of the Hypothalamic
18
George P. Chrousos, M.D.
Pituitary-Adrenal Axis Following Curative Resection of Adrenal Tumors in Patients with Cushing's Syndrome.
Surgery 108:1085-90.
155.
Hurley D., Accilli D., Stratakis C., Karl M., Vamvakopoulos N., Rorer E., Constantine K., Taylor S., Chrousos G.P.
(1991) Point Mutation Causing a Single Amino Acid Substitution in the Hormone Binding Domain of the
Glucocorticoid Receptor in Familial Glucocorticoid Resistance. J. Clin. Invest. 87:680-686.
156.
Laue L., Lotze M.T., Chrousos G.P., Barnes K., Loriaux D.L., Fleisher T.A. (1990) Effects of the Glucocorticoid
Antagonist RU 486 in Man: Toxicity, Immunological and Hormonal Aspects. J. Clin. Endocrinol. Metab. 71:14741480.
157.
Gomez M.T., Malozowski S, Winterer J., Chrousos G.P. (1991) Urinary Free Cortisol Values in Normal Children
and Adolescents. J. Pediatrics 118:256-258.
158.
Bernardini R., Calogero A., Mauceri, Chrousos G.P. (1990) Rat Hypothalamic Corticotropin Releasing Hormone
Secretion In Vitro is Stimulated by Interleukin-1 in an Eicosanoid-dependent Manner. Life Sciences 47:1601-7.
159.
Bagdy G., Calogero A., Szemeredi K., Gomez M.T., Sved A.F., Murphy D.L., Chrousos G.P., Gold P.W. (1990) Endorphin Responses to Different Serotonin Agonists: Involvement of Corticotropin Releasing Hormone,
Vasopressin and Direct Pituitary Action. Brain Res. 537(1-2):227-32.
160.
Bagdy G., Calogero A., Szemeredi K., Chrousos G.P., Gold P.W. (1990) effects of Cortisol Treatment on Brain and
Adrenal Cortcotropin Releasing Hormone Content. Regulat. Peptides 31:83-92.
161.
Doppman J.L., Nieman L.K., Travis W.D., Miller D.L., Cutler G.B., Chrousos G.P. Norton J.A. (1991) CT and MR
Imaging of Massive Macronodular Adrenocortical Disease: A Rare Cause of Autonomous Primary Adrenal
Hypercortisolism. J. Comp. Asst. Tom. 15:773-779.
162.
Bagdy G., Chrousos G.P., Calogero A. (1991) Circadian Patterns of Plasma Corticotropin, - Endorphin,
Corticosterone and Prolactin after Immunoneutralization of Corticotropin-releasing Hormone. Neuroendocrinology
53:573-578.
163.
Joseph-Vanderpool J., Rosenthal N., Chrousos G.P., Wehr T., Skewerer R., Kasper S., Gold P.W. (1991) Evidence
for Hypothalamic CRH Deficiency in Patients with Seasonal Affective Disorder. J. Clin. Endocrinol. Metab.
72:1382-1387.
164.
Doppman J., Pass H., Nieman L.K., Findling J., Dwyer A., Feuerstein I., Ling A., Travis W., Cutler G.B., Chrousos
G.P., Loriaux D.L. (1991) Magnetic Resonance Imaging for Detection of ACTH- producing Bronchial Carcinoid
Tumors, Am. J. Roentgen. 156:39-43.
165.
Johnson E.O., Kamilaris T.C., Carter S., Gold P.W., Chrousos G.P.. (1991) Environmental Stress and Reproductive
Success in the Common Marmoset (Callithrix jacchus jacchus) Am. J. Primatol 25:191- 201 (1991).
166.
Kling M.A., Doran A., Rubinow D.R., Roy A., Post R.M., Chrousos G.P., Gold P.W. (1991) CSF Levels of CRH,
ACTH, and SRIF in Cushing's Syndrome, Major Depression, and Normal Volunteers: Physiological and
Pathophysiological Interrelationships. J. Clin. Endocrinol. Metab. 72:260-271.
167.
Laue L., Peck G., Gallucci W.T., Loriaux D.L., Chrousos G.P. (1991) Adrenal Androgen Secretion in
Postadolescent Cystic Acne: Increased Adrenocortical Function without Hypersensitivity to ACTH. J. Clin.
Endocrinol. Metab. 73:380-384.
168.
Calogero A.E., Liapi C., Chrousos G.P. (1991) Hypothalamic and Suprahypothalamic Effects of Prolonged
treatment with the Glucocorticoid Type II Receptor Agonist Dexamethasone in the Rat. J. Endocrinol. Invest.
14:277-286.
169.
Smoak B., Deuster P., Rabin D., Chrousos G.P. (1991) Corticotropin-Releasing Hormone is Not the Sole Factor
Mediating Exercise-induced ACTH Release in Humans. J. Clin. Endocrinol. Metab. 72:302-306.
19
George P. Chrousos, M.D.
170.
Sombolos K., Kapetanos G., Kalogeras K.T., Christodoulou A., Chrousos G.P., Symeonidis P. (1991) Effect on
Atrial Natriuretic Peptide by Bracing in Scoliosis. Boston Brace Removal Studied in 10 cases. Acta Orthop Scand.
62:379-82.
171.
Waltman C., Blackman M.R., Chrousos G.P., Riemann C., Harman S.M. (1991) Spontaneous and Glucocorticoidinhibited Adrenocorticotropic Hormone and Cortisol Secretion Are Similar in Healthy Young and Old Men. J. Clin.
Endocrinol. Metab. 73:495-502.
172.
Perini G.I., Dervinsky O., Hauser P., Gallucci W.T., Theodore W., Chrousos G.P., Gold P.W., Kling M.A. (1992)
Effects of Carbamazepine on Pituitary-adrenal Function in Healthy Volunteers. J. Clin. Endocrinol. Metab. 74:406412.
173.
Travis W.D., Linnoila R., Tsokos M., Hitchcock C., Cutler G., Nieman L., Chrousos G.P., Pass H., Doppman J.
(1991) Neuroendocrine Tumors of the Lung with Proposed Criteria for Large Cell Neuroendocrine Carcinoma: An
Ultrastructural, Immunochemical, and Flow Cytometric Study of 35 Cases. Amer. J. Surg. Path. 15:529-553.
174.
Demitrack M., Dale J., Straus S., Laue L., Listwak S., Kruesi M., Chrousos G.P., Gold P.W. (1991) Evidence of
Impaired Activation of the Hypothalamic-pituitary-adrenal Axis in Patients with Chronic Fatigue Syndrome. J. Clin.
Endocrinol. Metab. 73:1224-1234.
175.
Karalis C., Sano H., Redwine J., Listwak S., Wilder R., Chrousos G.P. (1991) Autocrine or Paracrine Inflammatory
Actions of Corticotropin Releasing Hormone In Vivo. Science 254:421-423.
176.
Friedman T.C., Thomas P.M., Fleisher T.A., Feuillan P., Parker R.I., Cassorla F., Chrousos G.P. (1991) Frequent
Occurrence of Asplenism and Cholelithiasis in Patients with Autoimmune Polyglandular Disease Type I. Amer. J.
Med. 91:625-630.
177.
Oldfield E.H., Doppman J., Nieman L.K., Chrousos G.P., Miller D.L., Katz D.A., Cutler G.B., Loriaux D.L. (1991)
Petrosal Sinus Sampling with and without Corticotropin Releasing Hormone in Patients with Cushing's Syndrome.
N. Engl. J. Med. 325:897-905.
178.
Susman E.J., Dorn L.D., Chrousos G.P. (1991) Negative Affect and Hormone Levels in Young Adolescents:
Concurrent and Predictive Perspectives. J. Youth Adolesc. 20:167-190.
179.
Calogero A., Sternberg E., Bagdy G., Smith G., Bernardini R., Aksentijevich S., Wilder R.L., Gold P.W., Chrousos
G.P. (1992) Neurotransmitter-induced Hypothalamic-pituitary-adrenal Axis Responsiveness is Defective in
Inflammatory Disease-Susceptible Lewis Rats: In vivo and In vitro Studies Suggesting Globally Defective
Hypothalamic CRH Secretion. Neuroendocrinology. 55:600-608.
180.
Calogero A.E., Norton J.A., Sheppard B.C., Listwak S.J., Cromack D.T., Wally R., Jensen R.T., Chrousos G.P.
(1992) Pulsatile Activation of the Hypothalamic - pituitary - adrenal Axis during Major Surgery. Metabolism
41:839-845.
181.
Aksentijevich S., Whitfield Jr H.J., Young III W.S., Wilder R.L., Chrousos G.P., Gold P.W., Sternberg E.M. (1992)
Arthritis-susceptible Lewis Rats Fail to Emerge from the Stress Non-responsive period. Dev. Brain Res. 65:115118.
182.
Flack M.R., Oldfield E.H., Cutler G.B., Zweig M.H., Melley J.D., Chrousos G.P., Loriaux D.L., Nieman L.K.
(1992) The Use of Urine Free Cortisol in the High Dose Dexamethasome Suppression Test for the Differential
Diagnosis of Cushing's Syndrome. Ann. Int. Med. 116:211-217.
183.
Kamilaris T., Johnson E., Calogero A.E., Kalogeras K., Bernardini R., Chrousos G.P., Gold P.W. (1992)
Cholecystokinin-octapeptide Stimulates Hypothalamic-pituitary-adrenal Function in Rats: Role of Corticotropinreleasing Hormone. Endocrinology 130:1764-1784.
184.
Calogero A.E., Kamilaris T.C., Johnson E.O., P.W., Chrousos G.P., (1992) "Peripheral" Benzodiazepine receptor
20
George P. Chrousos, M.D.
Ligands Stimulate Prolactin Release in the Rat. J. Neuroendocrinology 2:745-750.
185.
Luger A., Watschinger B., Deuster P., Svoboda T., Clodi M., Chrousos G.P. (1992) Plasma Growth Hormone and
Prolactin Responses to Graded Levels of Acute Exercise and to a Lactate Infusion. Neuroendocrinology 56:112117.
186.
Marini J.C., Bordenick S., Heavner G., Rose S., Hintz R., Rosenfeld R., Chrousos G.P. (1993). The Growth
Hormone and Somatomedin Axis In Short Children with Osteogenesis Imperfecta. J. Clin. Endocrinol. Metab.
76:251-256.
187.
Vamvakopoulos N., Mayol V., Margioris N., Chrousos G.P. (1992) Lack of Dexamethasone Modulation of mRNAs
involved in the Glucocorticoid Signal Transduction Pathway in Two Cell Systems. Steroids 57:1-6.
188.
Cash J.M., Crofford L.J., Gallucci W.T., Sternberg E.M., Gold P.W., Chrousos G.P. and Wilder R.L. (1992)
Pituitary-adrenal Axis Responsiveness to Ovine CRH in Patients with Rheumatoid Arthritis Treated with Low-dose
Prednisone. J. Rheumatol. 19:1692-6.
189.
Deuster P.A., Singh A., Hofmann A., Moses F.M., Chrousos G.P.. (1992) Hormonal Responses to Ingesting Water
or a Carbohydrate Beverage During a 2h Run. Med. Sci. Sport Exerc. 24:72-79.
190.
Burnet P., Meffor I.N., Smith C.C., Chrousos G.P., Gold P.W., Sternberg E.M. (1992) Hippocampal [ 3H]-8hydroxy-2,3-(diphenylalanine)-tetralin binding site densities, serotonin receptor (5-HT1A) messenger ribonucleic
acid abundance and serotonin levels parallel the activity of the hypothalamopituitary-adrenal axis in rat. J.
Neurochemistry 59:1062-1070.
191.
Sternberg E.M., Glowa J., Smith M.A., Calogero A.E., Listwak S.J., Aksentijevich S., Chrousos G.P., Wilder R.L.,
and Gold P.W. (1992) Corticotropin Releasing Hormone Related Behavioral and Neuroendocrine Responses to
Stress in Lewis and Fischer Rats. Brain Res. 570:54-60.
192.
Roy M.S., Roy A., Gallucci W.T., Collier B., Young K., Kamilaris T.C., Chrousos G.P. (1993) The Ovine
Corticotropin Releasing Hormone Test in Type I Diabetic Patients and Controls: Suggestion of Mild Chronic
Hypercortisolism. Metabolism 42:696-700.
193.
Patchev V., Kalogeras K., Zelazowski P., Wilder R.L., Chrousos G.P. (1992). Increased Plasma Concentrations and
Hypothalamic Content and In Vitro Release of Arginine-Vasopressin in Inflammatory Disease-prone, Hypothalamic
CRH-deficient Lewis Rats. Endocrinology 131:1453-1457.
194.
Kling A., Rubinow D.R., Doran A.R., Roy A., Davis C.L., Calabrese J.R., Nieman L.K., Post R.M., Chrousos G.P.,
Gold P.W. (1993) Cerebrospinal Fluid Immunoreactive Somatostatin Concentrations in Patients with Cushing's
Disease and Major Depression: Relationship to Indices of Corticotropin-Releasing Hormone and Cortisol Secretion.
Neuroendocrinology 57:79-88.
195.
Chikanza I.C., Petrou P., Chrousos G.P., Kingsley G., and Panayi G. (1992) Detective Hypothalamic Response to
Immune/Inflammatory Stimuli in Patients with Rheumatoid Arthritis. Arthritis and Rheumatism 35:1281-1288.
196.
Karl M., Lamberts S.W., Detera-Wadleigh S., Encio I.J., Stratakis C.A., Hurley D.M., Accili D., Chrousos G.P.
(1993) Familial Glucocorticoid Resistance Caused by a Splice Site Deletion in the Human Glucocorticoid Receptor
Gene. J. Clin. Endocrinol. Metab. 76:683-89.
197.
Crofford L.J., Sano H., Karalis K., Webster E.L., Goldmuntz E.A., Chrousos G.P., Wilder R.L. (1992) Local
Secretion of Corticotropin Releasing Hormone in the Joints of Lewis Rats with Inflammatory Arthritis. J. Clin.
Invest. 90:2555-2564.
198.
Doppman J.L., Pass H.I., Nieman L.K., Miller D.L., Chang R., Cutler G.B., Chrousos G.P., Jaffe G.S., Norton J.A.
(1992) Corticotropin-secreting Carcinoid Tumors of the Thymus: Diagnostic Unreliability of Thymic Venous
Sampling. Radiology 184:71-74.
21
George P. Chrousos, M.D.
199.
Cizza G., Brady L., Calogero A., Bagdy G., Lynn A.B., Kling M.A., Blackman M.R., Chrousos G. P., Gold P.W.
(1992) Central Hypothyroidism is Associated with Advanced Age in Male Fischer 344/N Rats: In Vivo and In Vitro
Studies. Endocrinology 131:2672-2680.
200.
Smith C.C., Hauser E., Renaud N.K., Leff A., Aksentijevich S., Chrousos G.P., Wilder R.L., Gold P.W., Sternberg
E.M. (1992) Increased Hypothalamic 3H-Flunitrazepam Binding in Hypothalamic- Pituitary-Adrenal Axis
Hyporesponsive Rats. Brain Res 569:295-299.
201.
Zelitch Yanovski S., Yanovski J.A., Gwirtsman H.E., Bernat A., Gold P.W., and Chrousos, G.P. (1993) Normal
Dexamethasone Suppression in Obese Binge and Non-binge Eaters with Rapid Weight Loss. J. Clin. Endocrinol.
Metab. 76:675-79.
202.
Yanovski J.A., Cutler G.B., Chrousos, G.P., Nieman L.K. (1993) Corticotropin-releasing Hormone stimulation
following low-dose dexamethasone administration: A new test to distinguish Cushings syndrome from PseudoCushings states. JAMA 269:2232-38.
203.
Zelazowski P., Smith M.A., Gold P.W., Chrousos G.P., Wilder R.L., Sternberg E.M. (1992) In Vitro Regulation of
Pituitary ACTH Secretion in Inflammatory Disease Susceptible Lewis and Inflammatory Disease Resistant Fischer
Rats. Neuroendocrinology 56:474-482.
204.
Bouzas E.A., Mastorakos G., Chrousos G.P., Kaiser-Kupfer M.I. (1993) Lisch Nodules in Cushing Disease.
Archives Ophthalmol. 111:439-40.
205.
Swain M.G., Patchev V., Vergalla T., Chrousos G.P., Jones E.A. (1993) Suppression of Hypothalamic- pituitaryadrenal Axis Responsiveness to Stess in a Rat Model of Acute Cholestasis. J. Clin. Invest. 91:1903-1908.
206.
Cizza G., Kvetnansky R., Tartaglia M.E., Blackman M.R., Chrousos G.P., Gold P.W. (1993) Immobilization Stress
Rapidly Decreases Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro in the male 344/N Fischer
Rat. Life Sciences 53:233-240.
207.
Crofford L.J., Sano H., Karalis K., Friedman T.C., Epps H.R., Remmers E.F., Mathern P., Chrousos G.P., Wilder
R.L. (1993) Corticotropin-releasing Hormone in Synovial Fluids and Tissues of Patients with Rheumatoid Arthritis
and Osteoarthritis. J. Immunology 151:1-10.
208.
Chikanza I.C., Petrou P., Chrousos G.P., Kingsley G., Panayi G.S. (1993) Excessive and Dysregulated Secretion of
Prolactin in Rheumatoid Arthritis: Immunopathogenetic and Therapeutic Implications. Br. J. Rheumatol. 32:445448.
209.
Gomez M.T., Magiakou M.A., Mastorakos G., Chrousos, G.P. (1993) The Pituitary Corticotroph is not the Rate
Limiting Step in the Postoperative Recovery of the Hypothalamic-pituitary-adrenal Axis in Patients with Cushing's
Syndrome. J. Clin. Endocrinol. Metab. 77:173-77.
210.
Vamvakopoulos N.C., Chrousos G.P. (1993) Regulated Activity of the Distal Promoter-like Element of the Human
Corticotropin-Releasing Hormone Gene and Secondary Structural Features of its Corresponding Transcripts. Mol.
Cell. Endocrinol. 94:73-78.
211.
Mastorakos G., Webster E.L., Friedman T.C., Chrousos G.P. (1993) Immunoreactive Corticotropin Releasing
Hormone (CRH) and its Binding Sites in the Rat Ovary. J. Clin. Invest. 92:961-968.
212.
Vamvakopoulos N.C., Fukuhara K., Patchev V.K., Chrousos G.P. (1993) Effect of Single and Repeated
Immobilization Stress on the Heat Shock Protein (HSP) 70/90 System in the Rat: Glucocorticoid-Independent,
Reversible Reduction of HSP90 in the Liver and Spleen. Neuroendocrinology 57:1057-1065.
213.
Yanovski J.A., Yanovski S.Z., Gold P.W., Chrousos G.P., (1993) Differences in the Hypothalamic- PituitaryAdrenal Axis of Black and White Women. J. Clin. Endocrinol. Metabol. 77:536-541.
214.
Yanovski J.A., Cutler G.B., Doppman J.L., Miller D.L., Chrousos G.P., Oldfield E.H., Nieman L.K. (1993) The
22
George P. Chrousos, M.D.
Limited Ability of Inferior Petrosal Sinus Sampling with Corticotropin-Releasing Hormone in Distinguishing
Cushing Disease from Pseudo-Cushing States or Normal Physiology. J. Clin. Endocrinology. Metab. 77:503-509.
215.
Vamvakopoulos N.C., Chrousos G.P., Griffin C.A., Hawkins A.L., Lee C., Jabs E.W. (1993) Mapping the Introncontaining Human hsp 90 (hspCAL4) Gene to Chromosome 14G32. Cytogenet Cell Gen. 64:224-226.
216.
Bouzas E.A., Scott M.H., Mastorakos S.G., Gold P.W., Chrousos G.P., Kaiser-Kupfer M.I. (1993) Central Serous
Chorioretinopathy in Endogenous Hypercortisolism. Arch. Ophthalmol. 111:1229-33.
217.
Vamvakopoulos N.C., Chrousos G.P. (1993) Evidence of Direct Estrogen Regulation of Human Corticotropin
Releasing Hormone Gene Expression: Potential Implications for the Sexual Dimorphism of the Stress Response and
Immune/Inflammatory Reaction. J. Clin. Invest. 92:1896-1902.
218.
Patchev V.K., Mastorakos G., Brady L.S., Redwine J., Wilder R.L., and Chrousos G.P. (1993) Increased Arginine
Vasopressin Secretion May Participate in the Enhanced Susceptibility of Lewis Rats to Inflammatory Disease.
Neuroendocrinology. 58:106-110.
219.
Reincke M., Karl M., Travis W., Chrousos G.P. (1993) No Evidence for Oncogenic Mutations in Guanine
Nucleotide Binding Proteins of Human Adrenocortical Neoplasms. J. Clin. Endocrin. Metabol. 77:1419-1422.
220.
Tsigos C., Arai K., Hung W., Chrousos G.P. (1993) Hereditary Isolated Glucocorticoid Deficiency is Associated
with Abnormalilties of the Adrenocorticotropin Receptor Gene. J. Clin. Invest. 92:2461-2485.
221.
Vamvakopoulos N.C., Durkin S., Nierman W., Chrousos G.P. (1993) Mapping the Human Adrenocorticotropin
Hormone (ACTHR) Gene to the Small Arm of Chromosome 18 (18p. 11.21- pter.) Genomics 18:454-455.
222.
Gallucci W.T., Baum A., Laue L., Rabin D.S., Chrousos G.P., Gold P.W., Kling M.A. (1993) Sex Differences in
Sensitivity of the Hypothalamic-Pituitary Adrenal Axis. Health Psychology 12:420-425.
223.
Mastorakos G., Chrousos G.P., Weber J. (1993) Recombinant Interleukin 6 Activates the Hypothalamic-PituitaryAdrenal Axis in Humans. J. Clin. Endocrinol. Metab. 27:1690-1694.
224.
Reincke M., Allolio B., Petzke F., Heppner C., Mbulamberi D., Winklemann W., Chrousos G.P. (1993) Thyroid
Dysfunction in African Trypanosomiasis: Evidence for Cytokine-Mediated Hypothyroidism. Clin. Endocrinol.
39:455-461.
225.
Nieman L.K., Oldfield E.H., Wesley R., Chrousos G.P., Loriaux D.L., Cutler G.B. Jr., (1993) A simplified Morning
Ovine Corticotropin-Releasing Hormone Stimulation Test for the Differential Diagnosis of ACTH-dependent
Cushing's Syndrome. J. Clin. Endocrinol. Metab.77:1308-1312.
226.
Reincke M. Allolio B., Arlt W., Heppner C., Petcke F., Mbulamberi D., Siekman L., Vollmer D., Winkleman W.,
Chrousos G.P. (1994) Impairment of Adrenocortical Function Associated with Increased Plasma Tumor Necrosis
Factor-alpha and Interleukin-6 Concentrations in African Trypanosomiasis. NeuroImmunoModulation 1:14-22.
227.
Doppman J., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Fraker D.L., Norton J.A., Jensen R.T. (1994)
Adrenocorticotropin Hormone-Secreting Islet Cell Tumors: Are They Always Malignant? Radiology 190:59-64.
228.
Zeiger M.A., Fraker D.L., Pass H.I., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Norton J.A. (1993) Effective
Reversibility of the Signs and Symptoms of Hypercorticosolism by Bilateral Adrenalectomy. Surgery 114:1138-43.
229.
Bouzas E.A., Mastorakos G., Friedman T.C., Scott M.H., Chrousos G.P., Kaiser-Kupfer M.I. (1993) Posterior
Subcapsular Cataract in Endogenous Cushing Syndrome: An Uncommon Manifestation. Invest. Ophthalmol. Vis.
Sci. 34:3497-3500.
230.
Magiakou M.A., Mastorakos G., Gomez M.T., Rose S.R., Chrousos G.P. (1994) Suppressed Spontaneous and
Stimulated Growth Hormone Secretion in Patients with Cushing Disease Before and After Surgical Cure. J. Clin.
Endocrinol. Metab. 78:131-137.
23
George P. Chrousos, M.D.
231.
Zelazowski P., Patchev V.K., Zelazowski E.B., Chrousos G.P., Gold P.W., Sternberg E.M. (1993) Release of
Hypothalamic Corticotropin-Releasing Hormone and Arginine Vasopressin by Interleukin-1 and -MSH: Studies in
Rats with Different Susceptibility to Inflammatory Disease. Brain Res. 631:22-26.
232.
Ram Z., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Doppman J., Oldfield E.H. (1994) Early Repeat Surgery for
Persistent Cushing's Disease. J. Neurosurg. 80:37-45.
233.
Patchev V.K., Karalis K., Chrousos G.P. (1994) Effect of Excitatory Amino Acid Transmitters on Hypothalamic
Corticotropin-Releasing Hormone (CRH) and Arginine Vasopressin Release: Implications for Pituitary-Adrenal
Regulation. Brain Res. 633:312-316.
234.
Vamvakopoulos N.C., Chrousos G.P. (1993) Structural Organization of the 5' Flanking Region of the Human
Corticotropin Releasing Hormone Gene. J DNA Sequencing and Mapping 4:197-206.
235.
DeBellis M., Chrousos G.P., Dorn L., Burke L., Helmers K., Kling M.A., Trickett P.K., Putnam F.W. (1994)
Hypothalamic-Pituitary-Adrenal Axis Dysregulation in Sexually Abused Girls. J. Clin Endocrinol. Metab. 78:249255.
236.
Kling M., Demitrack M., Whitfield H. Jr., Kalogeras K., Listwak S., DeBellis M., Chrousos G.P., Gold P.W., Brandt
H. (1993) Effects of the Glucocorticoid Antagonist RU 486 on Pituitary-Adrenal Function in Patients with Anorexia
Nervosa and Healthy Volunteers: Enhancement of Plasma ACTH and Cortisol Secretion in Underweight Patients.
Neuroendocrinol. 57:1082-1091.
237.
Reincke M., Karl M., Travis W., Mastorakos G., Allolio B., Linehan M.H., Chrousos G.P., (1994) P53 Mutations in
Human Adrenocortical Neoplasms: Immunohistochemical and Molecular Studies. J. Clin. Endocrinol. Metab.
78:790-794.
238.
Cizza G., Kalogeras A.E., Brady L.S., Bagdy G., Bergamini E., Blackman M.R., Chrousos G.P., Gold P.W. (1994)
Male 344 Fischer Rats Show a Progressive Central Impairment of the Hypothalamic-Pituitary-Adrenal-Axis with
Advancing Age. Endocrinology 134:1611-1620.
239.
Friedman T.C., Garcia-Borreguero D., Hardwick D., Akuete C.N., Stambuk M.K., Dorn G.B.Jr., Nieman L.K.,
Chrousos G.P. (1994) Diurnal Rhythm of Plasma Delta Sleep-Inducing Peptide in Humans: Evidence for Positive
Correlation with Body Temperature and Negative Correlation with REM Slow Wave Sleep. J. Clin. Endocrin. &
Metab. 78:1085-1089.
240.
Karalis K., Mastorakos G., Chrousos G.P., Tolis G. (1994) Somatostatin Analogs Suppress the Inflammatory
Reaction In Vivo. J. Clin. Invest. 93:2000-2006.
241.
Kawatito Y., Sano H., Kawata M., Yuri K., Yamamura Y., Kato H., Chrousos G.P., Wilder R.L., Kondo M. (1994)
Local Secretion of Corticotropin Releasing Hormone by Enterochromafin Cells in Human Colon. Gastroenterology
106:859-65.
242.
Magiakou M.A., Mastorakos G., Oldfield E.H., Gomez M.T., Doppman J.L., Cutler G.B. Jr., Nieman L.K.,
Chrousos G.P. (1994) Cushing Syndrome in Children and Adolescents: Presentation, Diagnosis and Therapy. N.
Engl. J. Med. 331:629-36.
243.
Auchus R.J., Mastorakos G., Friedman T.C., Chrousos G.P. (1994) Corticotropin-Releasing Hormone Production
by a Small Cell Carcinoma in a Patient with ACTH-dependent Cushing Syndrome. J. Endocrinol. Invest. 17:447452.
244.
Petrides J.S., Mueller G.P., Kalogeras K.T., Chrousos G.P., Gold P.W., Deuster P.A. (1994) Exercise- induced
Activation of the Hypothalamic-Pituitary-Adrenal Axis: Marked Differences in the Sensitivity to Glucocorticoid
Suppression. J. Clin. Endocrinol. Metab. 79:377-383.
245.
Riddick L., Chrousos G.P., Jeffries S., Pang S. (1994) Comparison of Adrenocorticotropin and Adrenal Steroid
24
George P. Chrousos, M.D.
Response to Corticotropin Releasing Hormone Versus Metyrapone Testing in Patients with Hypopituitarism.
Pediatric Research 36:215-220.
246.
Scopa C.D., Mastorakos M., Friedman T.C., Melachrinou M.C., Merino M.J., Chrousos G.P. (1994) Presence of
Immunoreactive Corticotropin Releasing Hormone (CRH) in Thyroid Lesions. Am. J. Pathology 145:1159-1167.
247.
Michelson D., Stone L., Galliven E., Magiakou M.A., Chrousos G.P., Sternberg E.M., Gold P.W. (1994) Multiple
Sclerosis is Associated with Alterations in Hypothalamic-Pituitary-Adrenal Function. J. Clin. Endocrinol. Metab.
79:848-853.
248.
Arai K., Tsigos C., Suzuki Y., Irony I., Karl M., Listwak S., Chrousos G.P. (1994) Physiological and Molecular
Aspects of Mineralocorticoid Receptor Action in Pseudohypoaldosteronism: A Responsiveness Test and Therapy. J.
Clin. Endocrinol. Metab. 79:1019-1023.
249.
Mastorakos G., Scopa C., Friedman T., Vryonidou A., Kattis D., Phenekos K., Chrousos G.P. (1994) Presence of
Immunoreactive Corticotropin Releasing Hormone in Normal and Polycystic Human Ovaries. J. Clin. Endocrinol.
Metab. 79:934-939.
250.
Mastorakos G., Weber J.S., Magiakou M.A., Gunn H., Chrousos G.P. (1994) Hypothalamic-Pituitary- Adrenal Axis
Activation and Stimulation of Systemic Vasopressin Secretion by Recombinant Interleukin 6 in Humans: Potential
Implications for the Syndrome of Inappropriate Vasopressin Secretion. J. Clin. Endocrinol. Metab. 79:1191-1197.
251.
Magiakou M.A., Mastorakos G., Chrousos G.P. (1994) Final Stature in Patients with Endogenous Cushing
Syndrome. J. Clin. Endocrinol. Metab. 79:1082-1085.
252.
Patchev V.K., Brady L.S., Karl M., Chrousos G.P. (1994) Gene Expression of hsp90 and Glucocorticoid Receptors
in the Brain: Evidence for Coordinate Regulation by Adrenal Steroid Levels In Vivo. Cell. Mol. Endocrinol.
103:57-64.
253.
Stratakis C.A., Chrousos G.P. (1994) Capillaritis (Purpura Simplex) Associated with Use of Aminoglutethimide in
Cushing's Syndrome. Am. J. Hospital Pharmacy 51:2589-2591.
254.
Beuschlein F., Reincke M., Karl M., Travis W.D., Jaursch-Hancke C., Abdelhamid S., Chrousos G.P., Allolio B.
(1994) Clonal Composition of Human Adrenocortical Neoplasms. Cancer Research 54:4927-4932.
255.
Bernadini R., Chiarenza A., Kamilaris T.C., Renaud N., Lempereur L., Demitrack M., Gold P.W., Chrousos, G.P.
(1994) In Vivo and In Vitro Effects of Arginine-Vasopressin Receptor Antagonists on the Hypothalamic-PituitaryAdrenal Axis in the Rat. Neuroendocrinology 60:503-508.
256.
Friedman T., Garcia D.B., Hardwick D., Akuete C., Doppman J., Dorn L., Barker C., Chrousos G.P. (1994)
Decreased Delta Sleep and Plasma Delta Sleep-Inducing Peptide Immunoreactivity in Patients with Cushing
Syndrome. Neuroendocrinology 60:626-634.
257.
Crofford L.J., Pillemer S.R., Kalogeras K.T., Cash J.M., Michelson D., Kling M.A., Sternberg E.M., Gold P.W.,
Chrousos G.P., Wilder R.L. (1994) Hypothalamic-Pituitary-Adrenal-Axis Perturbation in Patients with
Fibromyalgia. Arthritis and Rheumatism 37:1583-1592.
258.
Michelson D., Chrousos G.P., Gold P.W. (1994) Type I Glucocorticoid Receptor Blockade Does Not Affect
Baseline or Ovine Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropic Hormone and Cortisol
Secretion. NeuroImmunoModulation 1:274-277.
259.
Mastorakos G., Cizza G., Kvetnansky R., Bergamini E., Blackman M.R., Gold P.W., Chrousos G.P. (1995) Aging
and Acute Stress Decrease Corticotropin Releasing Hormone in the Ovary of the Fischer 344/N Rat. Life Sciences
56:1065-1071.
260.
261.
Latronico A.C., Reincke M., Mendonca B.B., Arai K., Mora P., Allolio B., Wajchenberg B.L.,
Chrousos, G.P., Tsigos C. (1995) No Evidence for Oncogenic Mutations in the Adrenocorticotropin Receptor
25
George P. Chrousos, M.D.
(ACTH-R) Gene in Human Adrenocortical Neoplasms. J. Clin. Endocrinol. Metab. 80:875-877.
262.
Arai K., Tsigos C., Suzuki Y., Listwak S., Zachman K., Zangeneh F., Rapaport R., Chanoine J.P., Chrousos G.P.
(1995) No Apparent Mineralocorticoid Receptor Defect in a Series of Sporadic Cases of Pseudohypoaldosteronism.
J. Clin. Endocrinol. Metab. 80:814-817.
263.
Cizza G., Pacak K., Kvetnansky R., Palkovits M., Goldstein D.S., Brady L.S., Fukuhara K., Bergamini E., Kopin
I.J., Blackman M.R., Chrousos G.P., Gold P.W. (1995) Decreased Stress Responsivity of the Central and Peripheral
Catecholaminergic Systems in the Aged 344/N Fischer Rat. J. Clin. Invest. 95:1217-1224.
264.
Heinrichs C., Deschepper J., Tsigos C., Drews R., Collu R., Dugardeyn C., Goyens P., Ghanem G.E., Bosson D.,
Chrousos G.P., Van Vliet G. (1995) Familial Adrenocorticotropin Unresponsiveness Associated with Alacrima and
Achalasia: Biochemical and Molecular Studies in Two Siblings with Clinical Heterogeneity. European J. Peds.
154:191-196.
265.
Bamberger C.M., Bamberger A.M., De Castro M., Chrousos G.P. (1995) Glucocorticoid Receptor- Beta, a Potential
Endogenous Inhibitor of Glucocorticoid Action in Humans. J. Clin. Invest. 95:2435-2441.
266.
Tsigos C., Arai K., Latronico A-C, DiGeorge A., Rapaport R., Chrousos G.P. (1995) A Novel Mutation of the
Adrenocorticotropin Receptor (ACTH-R) Gene in a Family with the Syndrome of Isolated Glucocorticoid
Deficiency but No ACTH-R Abnormalities in Two Families with Triple A Syndrome. J. Clin. Endocrinol. Metab.
80:2186-2189.
267.
Mastorakos G., Patchev V.K., Chader G.J., Chrousos G.P., Gaudet S.J. (1995) Differences in arylakylamine NAcetyltransferase Activity Between Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats.
Neuroendocrinology 62:71-78.
268.
Doppman J.L., Nieman L.K., Chang R., Yanovski J.A., Cutler G.B. Jr., Chrousos G.P., Oldfield E.H. (1995)
Selective Venous Sampling from the Cavernous Sinuses is not a More Reliable Technique than Sampling from the
Inferior Petrosal Sinuses in Cushing Syndrome. J. Clin. Endocrinol. Metab. 80:2485-2489.
269.
Karalis K., Crofford L., Wilder R.L., Chrousos G.P. (1995) Glucocorticoid and/or Glucocorticoid Antagonist Effects
in Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats. Endocrinology 136:3107-3112.
270.
Karalis K., Mastorakos G., Sano H., Davis C., Wilder R.L., Chrousos G.P. (1995) Somatostatin May Participate in
the Antiinflammatory Actions of Glucocorticoids. Endocrinology 136:4133-4138.
271.
Pacak K., McCarty R, Palkovitz M., Cizza G., Kopin I.J., Goldstein D., Chrousos G.P. (1995) Decreased Central
and Peripheral Catecholaminergic Activation in Obese Zucker Rats. Endocrinology 136:4360-4367.
272.
Mastorakos G., Bouzas E., Caspi R., Friedman T., Chrousos G.P. (1995) Immune Corticotropin Releasing Hormone
(CRH) is Present in the Eyes of and Promotes Experimental Autoimmune Uveoretinitis (EAU) in Rodents.
Endocrinology 136:4650-4658.
273.
Stratakis C.A., Mitsiadis N.S., Sun D., Chrousos G.P., O'Connell A. (1995) Recurring Oral Giant Cell Lesion in XLinked Hypophosphatemic Rickets: Clinical Manifestation of Occult Hyperparathyroidism? J. Pediatrics 127:444446.
274.
Vgontzas A.N., Friedman T.C., Chrousos G.P., Bixler E.O., Vela-Bueno A., Kales A. (1995) Delta Sleep-Inducing
Peptide in Normal Humans and in Patients with Sleep Apnea and Narcolepsy. Peptides 16:1153-1156.
275.
Dorn L.D., Burgess E.S., Dubbert B., Kling M., Gold P.W., Chrousos G.P. (1995) Psychopathology in Patients with
Endogenous Cushing Syndrome: "Atypical" or "Melancholic" Features. Clin. Endocrinol. (Oxf.) 43:433-442.
276.
Cizza G., Gold P.W., Chrousos G.P. (1995) The Stress-Induced Inhibition of the Hypothalamic- Pituitary-Thyroid
Axis is Attenuated in the Aged Fischer 344/N Male Rat. Neuroendocrinology 62:506-13.
26
George P. Chrousos, M.D.
277.
Theoharides T.C., Spanos C., Pang Z., Alferes L., Ligris K., Letourneau R., Rozniecki J.J., Webster E., Chrousos
G.P. (1995) Stress-Induced Intracranial Mast Cell Degranulation. A Corticotropin-Releasing Hormone-Mediated
Effect. Endocrinology 136:5745-50.
278.
Yanovski J.A., Yanovski S.Z., Harrington L., Gold P., Chrousos G.P. (1995) Differences in the HypothalamicPituitary-Adrenal Axis of Black and White Men. Hormone Research 44:208-212.
279.
Chen H., Doppman J.L., Chrousos G.P., Norton J.A., Nieman L.K., Udelsman R.
Pheochromocytomas: The Exception to the Rule. Surgery 118:988-995.
280.
Yu K.C., Alexander H.R., Ziessman H.A., Norton J.A., Buell J.F., Nieman L.K., Cutler Jr G.B., Chrousos G.P.,
Fraker D.L. (1995) The Role of Pre-Operative Iodocholesterol Scintiscanning in Patients Undergoing
Adrenalectomy for Cushing's Syndrome. Surgery 118:981-987.
281.
Amikura K., Alexander R.H., Norton J.A., Doppman J.L., Jensen R.T., Nieman L.K., Cutler G.B., Chrousos G.P.,
Fraker D.L. (1995) The Role of Surgery in Management of ACTH-Producing Islet Cell Tumors of the Pancreas.
Surgery 118:1125-1130.
282.
Kawahito Y., Sano H., Mukai S., Asai K., Kimura S., Yamamura Y., Kato H., Chrousos G.P., Wilder R.L., Kondo
M. (1995) Corticotropin Releasing Hormone in Colonic Mucosa in Patients with Ulcerative Colitis. GUT 37:544551.
283.
Stratakis C.A., Carney A., Ping J., Papanicolaou D.A., Karl M., Kastner D.L., Pras E., Chrousos G.P. (1996)
Carney Complex, a Familial Multiple Neoplasia and Lentiginosis Syndrome: Analysis of 11 Kindreds and Linkage
to the Short Arm of Chromosome 2. J. Clin. Invest. 97:699-705.
284.
Karl M., Von Wichert G., Kempter E., Katz D.A., Reincke M., Monig H., Ali I.U., Stratakis C.A., Oldfield E.H.,
Chrousos G.P., Schulte H.M. (1996) Nelson's Syndrome Associated with a Somatic Frame Shift Mutation in the
Glucocorticoid Receptor Gene. J. Clin. Endocrinol. Metab. 81:124-129.
285.
Ghizzoni L., Mastorakos G., Vottero A., Magiakou M.A., Chrousos G.P., Bernasconi S. (1996) Spontaneous
Cortisol and Growth Hormone Secretion Interactions in Patients with Nonclassic 21-Hydroxylase Deficiency
(NCCAH) and Control Children. J. Clin. Endocrinol. Metab. 81:482-487.
286.
Latronico A.C., Anasti J., Arnhold I.J.P., Rapaport R., Mendonca B.B., Bloise W., de Castro M., Tsigos G.,
Chrousos G.P. (1996) Testicular and Ovarian Resistance to Luteinizing Hormone Caused by Homozygous
Inactivating Mutations of the Luteinizing Hormone Receptor Gene. N. Engl. J. Med. 334:507-512.
287.
Johnson E.O., Decker L., Gold P.W., Chrousos G.P. (1996) Distribution of Hippocampal Mineralocorticoid and
Glucocorticoid Receptor mRNA in a Glucocorticoid Resistant Nonhuman Primate. Steroids 61:69-73.
288.
Petzke F., Heppner C., Mbulamberi D., Winkelmann W., Chrousos G.P., Allolio B., Reincke M. (1996)
Hypogonadism in Rhodesian Sleeping Sickness: Evidence for Acute and Chronic Dysfunction of the HypothalamicPituitary-Gonadal Axis. Fertility and Sterility 65:68-75.
289.
Mastorakos G., Scopa C.D., Kao L.C., Vryonidou A., Friedman T.C., Kattis D., Phenekos C., Rabin D., Chrousos
G.P. (1996) Presence of Immunoreactive Corticotropin Releasing-Hormone (CRH) in Human Endometrium. J.
Clin. Endocrinol. Metab. 81:1046-1050.
290.
Dorn L.D., Burgess E.S., Dichek H.L., Putnam F., Chrousos G.P., Gold P.W. (1996) Thyroid Hormone
Concentrations in Depressed and Non-Depressed Adolescents: Group Differences and Behavioral Relations. J. Am.
Acad. Child Adolesc. Psychiatry 35:299-306.
291.
Leong, G.M., Mercado-Asis, L.B., Reynolds, J.C., Oldfield, E.H., Chrousos, G.P. (1996) The Effect of Cushing
Disease on Bone Mineral Density, Body Composition, Growth and Puberty: A Report of an Identical Adolescent
Twin Pair. J. Clin. Endocrinol. Metab. 81:1905-1911.
(1995) ACTH- Secreting
27
George P. Chrousos, M.D.
292.
Magiakou, M.A., Mastorakos, G., Rabin, D., Dubbert, B., Gold, P.W., Chrousos, G.P. (1996) Hypothalamic
Corticotropin Releasing Hormone Suppression during the Postpartum Period: Implications for the Increase of
Psychiatric Manifestations during this Time. J. Clin. Endocrinol. Metab. 81:1912-1917.
293.
Karl M., Saviolakis G.A., Gravanis A., Chrousos G.P., Margioris A.N. (1996) The PC 12 Rat Pheochromocytoma
Cell Line Expresses the Prodynorphin Gene and Secretes the 8 kdalton Dynorphin Product. Regulatory Peptides
61:99-104.
294.
Magiakou M.A., Mastorakos G., Rabin D., Margioris A.N., Dubbert B., Calogero A.E., Tsigos C., Munson P.J.,
Chrousos, G.P. (1996) The Maternal Hypothalamic-Pituitary-Adrenal Axis in Third Trimester Human Pregnancy.
Clin. Endocrinol. (Oxf.) 44:419-428.
295.
Kalogeras K.T., Nieman L.K., Friedman T.C., Dopppman J.L., Cutler G.B. Jr., Chrousos G.P., Wilder R.L., Gold
P.W., Yanovski J.A. (1996) Inferior Petrosal Sinus Sampling in Normal Human Subjects Reveals a Unilateral
Corticotropin-Releasing Hormone-Induced Arginine Vasopressin Release Associated with Ipsilateral Adrenal
Corticotropin Secretion. J. Clin. Invest. 97:2045-2050
296.
Johnson E.O., Kamilaris T.C., Calogero A.E., Gold P.W., Chrousos G.P. (1996) Effects of Early Parenting on
Growth and Development in a Small Primate. Pediatric Research 39:999-1005.
297.
Papanicolaou, D.A., Tsigos, C., Oldfield, E.H., Chrousos, G.P. (1996) Acute Glucocorticoid Deficiency is
Associated with Plasma Elevation of Interleukin-6: Does the Latter Participate in the Symptomatology of the Steroid
Withdrawal Syndrome and Adrenal Insufficiency? J. Clin. Endocrinol. Metab. 81:2303-2306.
298.
Dorn L.D., Burgess E.S., Susman E.J., Von Eye A., DeBellis M.D. Gold P.W., Chrousos G.P. (1996) Response to
Ovine Corticotropin Releasing Hormone in Depressed and Nondepressed Adolescents: Does Gender Make a
Difference? J. Am. Acad. Child Adolesc. Psychiatry 35:764-773.
299.
Burgess E.S., Dorn L.D., Haaga D., Chrousos G.P (1996) Sociotropy, Autonomy, Stress and Depression in Cushing
Syndrome. J. Nerv. Ment. Dis. 184:362-367.
300.
Karl M., Lamberts S.W.J., Koper J.W., Katz, D.A., Huizenga N.E., Kino T., Haddad B.R., Hughes M.R., Chrousos
G.P. (1996) Cushing's Disease Preceded by Generalized Glucocorticoid Resistance: Clinical Consequences of a
Novel, Dominant-negative Glucocorticoid Receptor Mutation. Proc. Assn. Amer. Phys. 108:296-307.
301.
Friedman, T.C., Nieman, L.K., Yanovski, J.A., Doppman, J.L., Cutler, G.B. Jr., Oldfield, E.H., Gold, P.W.,
Chrousos, G.P., Kalogeras, K.T. (1996) Inferior Petrosal Sinus Arginine Vasopressin Concentrations in Normal
Volunteers and Patients with Cushing Disease. J. Clin. Endocrinol. Metab. 81:3068-3072.
302.
Yanovski, J.A., Zelitch-Yanovski, S.A., Friedman, T.C., Loh Peng, Y., Jayasvasti, V., Cutler, G.B. Jr., Chrousos,
G.P. (1996) Etiology of the Differences in Corticotropin-Releasing Hormone-Induced ACTH Secretion of Black
and White Women. J. Clin. Endocrinol. Metab. 81:3307-3311.
303.
Makrigiannakis A., Zoumakis E., Margioris A.N., Stournaras C., Chrousos G.P., Gravanis A. (1996) Regulation of
the Promoter of the Human Corticotropin-Releasing Hormone (CRH) Gene in Transfected Human Endometrial
Cells. Neuroendocrinology 64:85-92.
304.
DeMarco, L., Stratakis, C.A., Boson, W.L., Jakbovitz, O., Carson, E., Andrade, L.M., Amaral, V.F., Rocha, J.L.,
Chrousos, G.P., Nordenskjöld, M., Friedman, E. (1996) Sporadic Cardiac Myxomas and Tumors from Patients
with Carney Complex are not Associated with Activating Mutations of the Gs Gene. Hum. Genet. 98:185-188.
305.
Papanicolaou D.A., Petrides J.S., Tsigos C., Bina S., Kalogeras K.T., Wilder R., Gold P.W., Deuster P.A., Chrousos
G.P. (1996) Exercise Stimulates Interleukin-6 Secretion: Inhibition By Glucocorticoids and Correlation With
Catecholamines. Am. J. Physiol. E601-E605.
306.
Johnson E.O., Kamilaris T.C., Carter C.S., Calogero A.E., Gold P.W., Chrousos G.P. (1996) The Biobehavioral
Consequences of Psychogenic Stress in a Small, Social Primate (Callithrix jacchus jacchus). Biol. Psychiatry
28
George P. Chrousos, M.D.
40:317-337.
307.
Castro M., Elliot S., Kino T., Bamberger C., Karl M., Webster E., Chrousos G.P. (1996) The Nonligand Binding Isoform of the Human Glucocorticoid Receptor (hGR): Tissue Levels, Mechanism of Action and Potential
Physiologic Role. Mol. Med. 2:597-607.
308.
Yanovski J.A., Yanovski S.Z., Cutler G.B. Jr., Chrousos G.P., Filmer K. (1996) Differences in the HypothalamicPituitary-Adrenal Axis of African American and Caucasian Girls. J. Pediatrics 129:130-136.
309.
Cizza G., Nieman L.K., Doppman J.L., Passaro M.D., Czerwiec F.S., Chrousos G.P., Cutler G.B. Jr. (1996)
Factitious Cushing Syndrome. J. Clin. Endocrinol. Metab. 81:3573-3577.
310.
Stratakis C.A., Jenkins R.B., Pras E., Mitsiadis C.S., Raff S.B., Stalboerger P.G., Tsigos C., Carney A., Chrousos
G.P. (1996) Cytogenetic and Mircosatellite Alterations in Tumors from Patients with the Syndrome of Myxomas,
Spotty Skin Pigmentation, and Endocrine Overactivity (Carney Complex). J. Clin. Endocrinol. Metab. 81:36073614.
311.
Reincke M., Wachenfeld C., Mora P., Thumser A., Jaursch-Hancke C., Abdelhamid S., Chrousos G.P., Allolio B.
(1996) p53 Mutations in Adrenal Tumors: Caucasian Patients Do Not Show the Exon 4 "Hot Spot" Found in
Taiwan. J. Clin. Endocrinol. Metab. 81:3636-3638.
312.
Michelson, D., Stratakis, C., Hill, L.Y., Reynolds, J., Galliven, E., Chrousos, G.P., Gold, P.W. (1996) Bone Mineral
Density is Decreased in Women With Depression. N. Engl. J. Med. 335:1176-1181.
313.
Elenkov I.J., Papanicolaou D.A., Wilder R.L., Chrousos G.P. (1996) Modulatory Effects of Glucocorticoids and
Catecholamines on Human Interleukin-12 and Interleukin-10 Production: Clinical Implications. Proc. Assn. Am.
Phys. 108:374-381.
314.
Stratakis C.A., Chrousos G.P. (1996) Transient Elevation of Serum Thyroid Hormone Levels Following Lithium
Discontinuation. Eur. J. Peds. 155:939-941.
315.
Wong M., Ramayya M.S., Chrousos G.P., Driggers P.H., Parker K.L. (1996) Cloning and Sequencing Analysis of
the Human Gene Encoding Steroidogenic Factor 1. J. Mol. Endocrinol. 17:139-147.
316.
Webster E.L., Lewis D.B., Torpy D.J., Zachman E.K., Rice K.C., Chrousos G.P. (1996) In Vivo and In Vitro
Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist:
Suppression of Pituitary ACTH Release and Peripheral Inflammation. Endocrinology 137:5747-5750.
317.
Cizza G., Brady L.S., Esclapes M., Blackman M.R., Gold P.W., Chrousos G.P. (1996) Age and Gender Influence
Basal and Stress-Modulated Hypothalamic-Pituitary-Thyroidal Function in Fischer 344/N Rats.
Neuroendocrinology 64:440-448.
318.
Stratakis C.A., Orban Z., Burns A.L., Vottero A., Mitsiades C.S., Marx S.J., Abbassi V., Chrousos G.P. (1996)
Dideoxyfingerprinting (ddF) Analysis of the Type X Collagen Gene (COL10A1) and Identification of a Novel
Mutation (S671P) in a Kindred with Schmid Metaphyseal Chondrodysplasia. Biochem. Mol. Med. 59:112-117.
319.
Friedman T.C., Mastorakos G., Newman T.D., Mullen N.M., Horton E.G., Costello R., Papadopoulos N.M.,
Chrousos G.P.. (1996) Carbohydrate and Lipid Metabolism in Endogenous Hypercortisolism: Shared Features with
Metabolic Syndrome X and Noninsulin-Dependent Diabetes Mellitus. Endocrine Journal 43:645-656.
320.
Stratakis C.A., Mitsiades N.S., Chrousos G.P., Margioris A.N. (1996) Dopamine Affects Rat Placenta Opioids in a
Receptor- and Opioid Type-Specific Manner. Eur. J. Pharmacol. 315:53-58.
321.
Oberfield S.E., Nirenberg A., Allen J.C., Cohen H., Donahue B., Prasad V., Schiff R., Pang S., Ghavimi F., David.,
Chrousos G.P., Sklar C. (1997) Hypothalamic-Pituitary-Adrenal Function Following Cranial Irradiation. Horm.
Res. 47:9-16.
29
George P. Chrousos, M.D.
322.
Susman E., Dorn L., Inoff-Germain G., Nottelmann E., Chrousos G.P. (1997) Cortisol Reactivity, Distress
Behavior, and Behavioral and Psychological Problems in Young Adolescents: A Longitudinal Perspective. J. Res.
Adolescence 7:81-105.
323.
Dorn L.D., Burgess E.S., Friedman T.C., Dubbert B., Gold P.W., Chrousos G.P. (1997) The Longitudinal Course of
Psychopathology in Cushing Syndrome After Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 82:912919.
324.
Sarlis N.J., Chrousos G.P., Doppman J.L., Carney J.A., Stratakis C.A. (1997) Primary Pigmented Nodular
Adrenocortical Disease: Reevaluation of a Patient with Carney Complex 27 Years After Unilateral Adrenalectomy.
J. Clin. Endocrinol. Metab. 82:1274-1278.
325.
Crofford L.J., Kalogeras K.T., Mastorakos G., Magiakou M-A., Wells J., Kanik K.S., Gold P.W., Chrousos G.P.,
Wilder R.L. (1997) Circadian Relationships Between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis
Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid
Arthritis. J. Clin. Endocrinol. Metab. 82:1279-1283.
326.
Licinio J., Mantzoros C., Negrão A.B., Cizza G., Wong M-L, Bongiorno P.B., Chrousos G.P., Karp B., Ellen C.,
Flier J.S., Gold P.W. (1997) Human Leptin Levels are Pulsatile and Inversely Related to Pituitary-Adrenal
Function. Nature Medicine 3:575-579.
327.
Taymans S.E., DeVries A.C., DeVries M.B., Nelson R.J., Friedman T.C., Castro M., Detera-Wadleigh S., Carter
C.S., Chrousos G.P. (1997) The Prairie Vole (Microtus ochrogaster) as a Model of Glucocorticoid Resistance.
Gen. Comp. Endocrinol. 106:48-61.
328.
Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Kales A., Tyson K., Chrousos G.P. (1997) Elevation of Plasma
Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity. J. Clin.
Endocrinol. Metab. 82:1313-1316.
329.
Magiakou M.A., Mastorakos G., Zachman K., Chrousos G.P. (1997) Blood Pressure in Children and Adolescents
with Cushing Syndrome Before and After Surgical Cure. J. Clin. Endocrinol. Metab. 82:1734-1738.
330.
Ramayya M.S., Zhou J., Kino T., Segars J.H., Bondy C.A., Chrousos G.P. (1997) Steroidogenic Factor-1 (hSF-1)
mRNA Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and In Situ Hybridization
Studies. J. Clin. Endocrinol. Metab. 82:1799-1806.
331.
Yanovski J.A., Yanovski S.Z., Gold P.W., Chrousos G.P. (1997) Differences in Corticotropin- Releasing HormoneStimulated Adrenocorticotropin and Cortisol Before and After Weight Loss. J. Clin. Endocrinol. Metab. 82:18741878.
332.
de Lange P., Koper J.W., Huizenga N.A.T.M., Brinkman A.O., de Jong F.H., Cato A.C.B., Karl M., Chrousos G.P.,
Lamberts S.W.J. (1997) Differential Hormone-Dependent Transactivation and Transrepression by Naturally
Occurring Human Glucocorticoid Receptor (GR) Variants. Mol. Endocrinol. 11:1156-1164
333.
Premkumar A., Stratakis C.A., Shawker T.H., Papanicolaou D.A., Chrousos G.P. (1997) Testicular Ultrasound in
Carney Complex: Report of Three Cases. J. Clin. Ultrasound. 25:211-214.
334.
Petrides J.S., Gold P.W., Mueller G.P., Singh A., Stratakis C.A., Chrousos G.P., Deuster P.A. (1997) Marked
Differences in Functioning of the Hypothalamic-Pituitary-Adrenal Axis Between Groups of Men. J. Appl. Physiol.
82:1979-1988.
335.
Reincke M., Beuschlein F., Latronico A-C., Arlt W., Chrousos G.P., Allolio B. (1997) Expression of
Adrenocorticotrophic Hormone Receptor mRNA in Human Adrenocortical Neoplasms: Correlation with P450scc
Expression. Clin. Endocrinol. (Oxford) 46:619-626.
336.
Michelson D., Galliven E., Hill L., Demitrack M., Chrousos G.P., Gold P. (1997) Chronic Imipramine is Associated
with Diminished Hypothalamic-Pituitary-Adrenal Axis Responsivity in Healthy Humans. J. Clin. Endocrinol.
30
George P. Chrousos, M.D.
Metab. 82:2601-2606.
337.
Cizza G., Lotsikas A.J., Licinio J., Gold P.W., Chrousos G.P. (1997) Plasma Leptin Levels Do Not Change in
Patients with Cushing’s Disease Shortly After Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 82:27472750.
338.
Tsigos C., Papanicolaou D.A., Defensor R., Mitsiades C.S., Kyrou I., Chrousos G.P. (1997) Dose Effects of
Recombinant Human Interleukin-6 on Piuitary Hormone Secretion and Energy Expenditure. Neuroendocrinology
66:54-62.
339.
Bamberger C.M., Bamberger A., Wald M., Chrousos G.P., Schulte H.M. (1997) Inhibition of Mineralocorticoid
Activity by the -Isoform of the Human Glucocorticoid Receptor. J. Steroid Biochem. and Mol. Biol. 60:43-50.
340.
Arnold I.J.P., Latronico A.C., Batista M.C., Carvalho F.M., Chrousos G.P., Mendonca B.B. (1997) Ovarian
Resistance to Luteinizing Hormone: A Novel Cause of Amenorrhea and Infertility. Fertil. Steril. 67:394-397.
341.
Reincke M., Mora P., Beuschlein F., Arlt W., Chrousos G.P., Allolio B. (1997) Deletion of the Adrenocorticotropin
Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis. J. Clin. Endocrinol. Metab.
82:3054-3058.
342.
Vgontzas A.N., Bixler E.O., Papanicolaou D.A., Kales A., Stratakis C.A., Vela-Bueno A., Gold P.W., Chrousos
G.P. (1997) REM Sleep Correlates with the Overall Activities of the Hypothalamic- Pituitary-Adrenal (HPA) Axis
and Sympathetic System in Healthy Humans. J. Clin. Endocrinol. Metab. 82:3278-3280.
343.
Ghizzoni L., Mastorakos G., Vottero A., Bareca A., Furlini M., Cesarone A., Ferrari B., Chrousos G.P., Bernasconi
S. (1997) Corticotropin-Releasing Hormone (CRH) Inhibits Steroid Biosynthesis by Cultured Human GranulosaLutein Cells in a CRH and Interleukin-1 Receptor -Mediated Fashion. Endocrinology 138:4806-4811.
344.
Yanovski J.A., Friedman T.C., Nieman L.K., Chrousos G.P., Cutler G.B. Jr., Doppman J.L., Kalogeras K.T. (1997)
Inferior Petrosal Sinus AVP in Patients with Cushing’s Syndrome. Clin. Endocrinol. 47:199-206.
345.
Stratakis C.A., Sarlis N.J., Berrettini W.H., Badner J.A., Chrousos G.P., Gershon E.S., Detera- Wadleigh S.D.
(1997) Lack of Linkage Between the Corticotropin-Releasing Hormone (CRH) Gene and Bipolar Affective
Disorder. Mol. Psychiatry 2:483-485.
346.
Ghizzoni L., Mastorakos G., Street M.E., Vottero A., Mazzardo G., Vanelli M., Chrousos G.P., Bernasconi S.
(1997) Spontaneous Thyrotropin and Cortisol Secretion Interactions in Patients with Nonclassical 21-Hydroxylase
Deficiency and Control Children. J. Clin. Endocrinol. Metab. 82:3677-3683.
347.
Leung D.Y.M., Hamid Q., Vottero A., Szefler S.J., Surs W., Minshall E., Chrousos G.P., Klemm D.J. (1997)
Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor. J. Exp. Med.
186:1567-1574.
348.
Tsigos C., Papanicolaou D.A., Kyrou I., Defensor R., Mitsiadis C.S., Chrousos G.P. (1997) Dose- Dependent
Effects of Recombinant Human Interleukin-6 on Glucose Regulation. J. Clin. Endocrinol. Metab. 82:4167-4170.
349.
Stratakis C., Magiakou M.A., Mastorakos G., Oldfield E., Chrousos G.P. (1997) Thyroid Function in Children with
Cushing Disease Before and After Transsphenoidal Surgery. J. Peds. 131:905-909.
350.
Theoharides T.C., Singh L.K., Boucher W., Pang X., Letourneau R., Webster E., Chrousos G.P. (1998)
Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A
Possible Explanation for Its Proinflammatory Effects. Endocrinology 139:403-413.
351.
Bornstein S.R., Licinio J., Tauchnitz R., Engelmann L., Negrão A.B., Gold P.W., Chrousos G.P. (1998) Plasma
Leptin Levels Are Increased in Survivors of Acute Stress: Associated Loss of Diurnal Rhythm in Cortisol and
Leptin Secretion. J. Clin. Endocrinol. Metab. 88:280-283.
31
George P. Chrousos, M.D.
352.
Yanovski J.A., Cutler G.B., Chrousos G.P., Nieman L.K. (1998) The Dexamethasone-Suppressed CorticotropinReleasing Hormone Stimulation Test Differentiates Mild Cushing’s Disease from Normal Physiology. J. Clin.
Endocrinol. Metab. 83:348-352.
353.
Papanicolaou D.A., Yanovski J.A., Cutler G.B. Jr., Chrousos G.P., Nieman L.K. (1998) A Single Midnight Serum
Cortisol Measurement Distinguishes Cushing’s Syndrome from Pseudo-Cushing States. J. Clin. Endocrinol. Metab.
83:1163-1167.
354.
Stratakis C.A., Vottero A., Brodie A., Kirschner L.S., DeAtkine D., Lu Q., Yue W., Mitsiades C.S., Flor A.W.,
Chrousos G.P. (1998) The Aromatase Excess Syndrome is Associated with Feminization of Both Sexes and
Autosomal Dominant Transmission of Aberrant P450arom Gene Transcription. J. Clin. Endocrinol. Metab.
83:1348-1357.
355.
Bornstein S.R., Webster E.L., Torpy D.J., Richman S.J., Mitsiades N., Igel M., Lewis D.B., Rice K.C., Joost H.G.,
Tsokos M., Chrousos G.P. (1998) Chronic Effects of a Nonpeptide Corticotropin- Releasing Hormone Type 1Receptor Antagonist on Pituitary-Adrenal Function, and Body Weight and Metabolic Regulation. Endocrinology
139:1546-1555.
356.
Yanovski J.A., Nieman L.K., Doppman J.L., Chrousos G.P., Wilder R.L., Gold P.W., Kalogeras K.T. (1998)
Plasma Levels of Corticotropin-Releasing Hormone in the Inferior Petrosal Sinuses of Healthy Volunteers, Patients
with Cushing’s Syndrome, and Patients with Pseudo-Cushing States. J. Clin. Endocrinol. Metab. 83:1485-1488.
357.
Gragerov A., Kino T., Ilyina-Gragerova G., Chrousos G.P., Pavlakis G.N. (1998) HHR23A, the Human
Homologue of the Yeast Repair Protein RAD23 Interacts Specifically with Vpr Protein and Prevents Cell Cycle
Arrest But Not the Transcriptional Effects of Vpr. Virology 245:323-330.
358.
Stratakis C.A., Mastorakos G., Mitsiades N.S., Mitsiades C.S., Chrousos G.P. (1998) Skin Manifestations of
Cushing Disease in Children and Adolescents Before and After the Resolution of Hypercortisolemia. Ped.
Dermatol. 15:253-258.
359.
Willenberg H.S., Stratakis C.A., Marx C., Ehrhart-Bornstein M., Chrousos G.P., Bornstein S.R. (1998) Aberrant
Interleukin-1 Receptors in a Cortisol-Secreting Adrenal Adenoma Causing Cushing’s Syndrome. N. Engl. J. Med.
339:27-31.
360.
Vgontzas A.N., Tsigos C., Kales A., Stratakis C.A., Zachman K., Bixler e.O., Velo-Bueno A., Chrousos G.P.
(1998) Chronic Insomnia and Activity of the Stress System: A Preliminary Study. J. Psychosomatic Res. 45:21-31.
361.
Elenkov I.J., Webster E.L., Papanicolaou D.A., Fleisher T.A., Chrousos G.P., Wilder R.L. (1998) Histamine
Potently Suppresses Human Interleukin-12 and Stimulates Interleukin-10 Production via H2 Receptors. J. Immunol.
161:2586-2593.
362.
Torpy D.J., Gordon R.D., Lin J-P., Huggard P.R., Taymans S.E., Stowasser M., Chrousos G.P., Stratakis C.A.
(1998) Familial Hyperaldosteronism Type-II: Description of a Large Kindred and Exclusion of the Aldosterone
Synthase (CYP11B2) Gene. J. Clin. Endocrinol. Metab. 83:3214-3218.
363.
Torpy D.J., Tsigos C., Lotsikas A.J., Defensor R., Chrousos G.P., Papanicolaou D.A. (1998) Acute and Delayed
Effects of a Single-Dose Injection of Interleukin-6 on Thyroid Function in Healthy Humans. Metabolism 47:12891293.
364.
Chan E.C., Falconer J., Madsen G., Read M., Chrousos G.P., Webster E.L., Rice K., Smith R.A. (1998)
Corticotropin-Releasing Hormone Type I Receptor Antagonist Delays Parturition in Sheep. Endocrinology139:
3357-3360.
365.
Longui C.A., Vottero A., Harris A.G., Chrousos G.P. (1998) Plasma Cortisol Responses After Intramuscular ACTH
1-24 in Healthy Men. Metabolism 47:1419-1422.
366.
Glasow A., Haidan A., Hilbers U., Breidert M., Gillespie J., Scherbaum W.A., Chrousos G.P., Bornstein S.R.
32
George P. Chrousos, M.D.
(1998) Expression of Ob Receptor in Normal Human Adrenals: Differential Regulation of Adrenocortical and
Adrenomedullary Function by Leptin. J. Clin. Endocrinol. Metab. 83:4459-4466.
367.
Torpy D.J., Bornstein S.R., Chrousos G.P. (1998) Leptin and Interleukin-6 in Sepsis. Horm. Metab. Res. 30:726729.
368.
Willenberg H.S, Bornstein S.R., Dumser T., Ehrhart-Bornstein M., Barocka A., Chrousos G.P., Scherbaum W.A.
(1998) Morphological Changes in Adrenals From Victims of Suicide in Relation to Altered Apoptosis. Endocrine
Research, 24:963-967.
369.
Deuster P.A., Petrides J.S., Singh A., Lucci E.G., Chrousos G.P., Gold P.W. (1998) High Intensity Exercise
Promotes Escape of ACTH and Cortisol From Suppression by Dexamethasone: Sexually Dimorphic Responses. J.
Clin. Endocrinol. Metab., 83:3332-3338.
370.
Kino T., Gragerov A., Kopp J.B., Stauber R.H., Pavlakis G.N., Chrousos, G.P. (1999) The HIV-1 Virionassociated Protein Vpr is a Coactivator of the Human Glucocorticoid Receptor. J. Exp. Med. 89:51-61.
371.
Deak T., Nguyen K.T., Ehrlich A.L., Watkins L.R., Spencer R.L., Maier S.F., Licinio J., Wong M-L, Chrousos G.P.,
Webster E., Gold P.W. (1999) The Impact of the Nonpeptide CRH Antagonist Antalarmin on Behavioral and
Endocrine Responses to Stress. Endocrinology. 140:79-86.
372.
Heino M., Scott H.S., Chen Q., Peterson P., Maenpaa U., Papasavvas M.P., Mittaz L., Barras C., Rossier C.,
Chrousos, G. P., Stratakis, C.A., Nagamine K., Kudoh J., Shimizu N., Maclaren N., Antonarakis S.E., and Krohn
K. (1999) Mutation Analyses of North American APS-1 Patients. Human Mutation 13: 69-74.
373.
Shahidi H., Vottero A., Stratakis, C.A., Taymans, S.E., Karl M., Longui, C.A., Chrousos, G.P.. Daughaday. W.H.,
Gregory, S.A., Plate, J.M.D. (1999) Imbalanced expression of the glucocorticoid receptor isoforms in cultured
lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia. Biochem
Biophys Res Commun 254:559-565.
374.
Vottero A, Stratakis CA, Ghizzoni L, Longui CA, Karl M., Chrousos G.P. (1999) Androgen receptor- mediated
Hypersensitivity to Androgens in Women with Nonhyperandrogenic Hirsutism: Skewing of X-chromosome
Inactivation. J. Clin. Endocrinol. Metab. 84:1091-1095.
375.
Tataranni P.A., Cizza G., Snitker S., Gucciardo F., Lotsikas A., Chrousos G.P., Ravussin E., (1999) Hypothalamicpituitary-adrenal Axis and Sympathetic Nervous System Activities in Pima Indians and Caucasians. Metabolism.
48:395-399.
376.
Torpy, D. J., Chen, C., Mullen, N., Doppman, J. L., Carrasquillo, J., Chrousos G.P., Nieman, L. K. (1999) Lack of
Utility of 111In-Pentetreotide Scintigraphy in Localizing Ectopic ACTH Producing Tumors: Follow-up of 18
Patients., J. Clin. Endocrinol. Metab. 84:1186-1192.
377.
Singh A., Papanicolaou D.A., Lawrence L.L., Howell E.A., Chrousos G.P., Deuster P.A. (1999) Neuroendocrine
Responses to Exhaustive Running in Women. Med. Sci. Sports Exerc. 31:536-542.
378.
Torpy D.J., Webster E.L., Zachman E.K., Aguilera G., Chrousos G.P. (1999) Urocortin and Inflammation:
Confounding Effects of Hypotension on Measures of Inflammation. Neuroimmunomodulation 6:182-186.
379.
Susman E.J., Schmeelk K.H., Worrall B.K., Granger D.A., Ponirakis A., Chrousos G.P. (1999) Corticotropin
Releasing Hormone and Cortisol: Longitudinal Associations with Depression and Antisocial Behavior in Pregnant
Adolescents. J. Amer. Acad. Chid and Adol. Psychiatry 38:460-467.
380.
Bottner A., Eisenhofer G., Torpy D.J., Ehrhart-Bornstein M., Keiser H.R., Chrousos G.P., Bornstein S.R. (1999)
Lack of Leptin Suppression in Response to Hypersecretion of Catecholamines in Pheochromocytoma Patients.
(Preliminary Report) Metabolism 48:543-545.
381.
Hamid Q.A., Wenzel S.E., Hauk P.J., Tsicopoulos A., Wallaert B., Lafitte J-J., Chrousos G.P., Szefler S.J., Leung
33
George P. Chrousos, M.D.
D.Y.M. (1999) Increased Glucocorticoid Receptor-beta in Airway Cells of Glucocorticoid- insensitive Asthma Am
J Respir Crit Care Med 159:1600-1604.
382.
Dorn L.D., Nottelmann E., Susman E.J., Inoff-Germain G., Cutler G.B. Jr., Chrousos G.P. (1999) Variability in
Hormone Concentrations and Self-reported Menstrual Histories in Young Adolescents: Menarche as an Integral Part
of a Developmental Process. J Youth & Adolescence 28:283-303.
383.
Yanovski J.A., Miller K.D., Kino T., Friedman T.C., Chrousos G.P., Tsigos C., Falloon J. (1999) Endocrine and
Metabolic Evaluation of HIV-infected Patients with Evidence of Protease Inhibitor Associated Lipodystrophy. J.
Clin. Endocrinol. Metab. 84:1925-1931.
384.
Orban, Z., Remaley, A.T., Sampson, M., Trajanoski, Z., Chrousos G.P. (1999) the Differential Effect of Food Intake
and -Adrenergic Stimulation of Adipose-Derived Hormones and Cytokines in Man. J. Clin. Endocrinol. Metab.
84:2126-2133.
385.
Singh, A., Petrides, J. S., Gold, P. W., Chrousos G.P., Deuster, P.A. (1999) Differential Hypothalamic-PituitaryAdrenal Axis Reactivity to Psychological and Physical Stress, J. Clin. Endocrinol. 84:1944-1948.
386.
Schmeelk, K. H., Granger, D. A., Susman, E. J., Chrousos G.P. (1999) Maternal Depression and Risk for
Postpartum Complications in Adolescents: Role of Prenatal Corticotrophin-releasing Hormone and Interleukin-1
Receptor Antagonist., Behaviorial Medicine, 25:88-94.
387.
Arai, K., Zachman, K., Shibasaki, T., Chrousos G.P. (1999) Polymorphisms of Amiloride Sensitive Sodium Channel
Subunits in Five Sporadic Cases of Pseudohypoaldosteronism: Do They Have Pathologic Potential? J. Clin.
Endocrinol. Metab., 84:2434-2437.
388.
Franchimont, D., Louis, E., Dupont, P., Vrindts-Gevaert, Y., Dewe, W., Chrousos G.P., Geenen, V., Belaiche, J.
(1999) Decreased Corticosensitivity in Quiescent Crohn’s Disease An Ex Vivo Study Using Whole Blood Cell
Cultures, Digestive Diseases and Sciences, 44:1208-1215.
389.
Wong, M., Webster, E. L., Spokes, H. Phu, P., Ehrhart-Bornstein, M., Bornstein, S., Park, C., Rice, K. C., Chrousos
G.P., Licinio, J., Gold, P. W. (1999) Chronic Administration of the Non-Peptide CRH Type 1 Receptor Antagonist
Antalarmin Does Not Blunt Hypothalamic-Pituitary-Adrenal Axis Responses to Acute Immobilization Stress, Life
Sciences, 65:53-58.
390.
Franchimont, D. Martens, H. Habelstein, M., Louis, E., Dewe, W., Chrousos G.P., Belaiche, J., Geenen, V. (1999)
Tumor Necrosis Factor Decreases, and Interleukin-10 Increases, the Sensitivity of Human Monocytes to
Dexamethasone: Potential Regulation of the Glucocorticoid Receptor, J. Clinical Endocrinology & Metabolism,
84:2834-2839.
391.
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M.,
Licinio, J., Gold, P. W., Hermida, R. C., Mastorakos, G., Chrousos G.P., (1999) Circadian Interleukin-6 Secretion
and Quality and Depth of Sleep, J. Clinical Endocrinology & Metabolism, 84:2603-2607.
392.
Vgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., Chrousos G.P., (1999) Sleep Deprivation
Effects on the Activity of the Hypothalamic-Pituitary-Adrenal and Growth Axes: Potential Clinical Implications,
Clinical Endocrinol. (Oxf.), 51:205-215.
393.
Macrigiannakis, A., Margioris, A., Chrousos G.P., Stounaras, C., Gravanis, A., (1999) The Decidualizing Effect of
Progesterone May Involve Direct Transcriptional Activation of Corticotropin Releasing Hormone (CRH) from
Human Endometrial Stroma Cells, Molecular Human Reproduction, 5:789-796.
394.
Kino T., Nordeen S.K., Chrousos G.P. (1999) Conditional Modulation of Glucocorticoid Receptor Activities by
CREB-binding Protein (CBP) and p300. J. Steroid Biochem. Molec. Biol., 70:15-25.
395.
Stratakis, C. A., Sarlis, N., Kirschner, L. S., Carney, J. A., Doppman, J. L., Nieman, L. K., Chrousos G.P.,
Papanicolaou, D. A., (1999) Paradoxic Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular
34
George P. Chrousos, M.D.
Adrenocortical Disease, Ann. Intern. Med., 131:585-591.
396.
Wolkersdorfer, G.W., Lohmann, T. Schroder, S., Marx, C., Pfeiffer, R., Stahl, H-D., Chrousos G.P., Bornstein,
S.R., (1999) Lymphocytes Stimulate Dehydroepiandrosterone Production Through Direct Cellular Contact with
Adrenal Zona Reticularis Cells: A Novel Mechanism of Immune-Endocrine Interaction, J. Clin. Endocrinol. Metab.,
84:4220-4227.
397.
Koch, C. A., Azumi, N., Furlong, M. A., Jha, R. C., Kehoe, T. E., Trowbridge, C. H., O’Dorisio, T. M., Chrousos
G.P., (1999) Clement, S. C., CLINICAL CASE SEMINAR: Carcinoid Syndrome Caused by an Atypical Carcinoid
of the Uterine Cervix, J. Clin. Endocrinol. Metab., 84:4208-4213.
398.
Torpy, D. J., Webster, E. L., Zachman, E. K., Aguilera, G., Chrousos G.P., (1999) Urocortin and Inflammation:
Confounding Effects of Hypotension on Measures of Inflammation, Neuroimmunomodulation, 6:182-186.
399.
Tsigos C., Papanicolaou D., Kyrou I., and Chrousos G. P. (1999) Dose Effects of Recombinant Human Interleukin-6
on the Pituitary-testicular Axis. J. Interferon and Cytokine Res. 19:1271-6
400.
Link, A. A., Kino, T. , Worth, J. A., McGuire, J. L., Crane, M. L., Chrousos G.P., Wilder, R. L., Elenkov, I. J.,
(2000) Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes, J.
Immunology, 164:436-442.
401.
Orban, Z., Mitsiades, N., Burke, Jr., T. R., Tsokos, M., Chrousos G.P., (2000) Caffeic Acid Phenethyl Ester Induces
Leukocyte Apoptosis, Modulates Nuclear Factor-Kappa B and Suppresses Acute Inflammation,
Neuroimmunomodulation, 7:99-105.
402.
Wong, M-L., Kling, M. A., Munson, P. J., Listwak, S., Licinio, J., Prolo, P., Karp, B., McCutcheon, I. E., Geracioti,
Jr. T. D., DeBellis, M. D., Rice, K. C., Goldstein, D. S., Veldhuis, J. D., Chrousos G.P., Oldfield, E. H., McCann, S.
M., Gold, P. W. (2000), Pronounced and Sustained Central Hypernoradrenergic Function in Major Depression with
Melancholic Features: Relation to Hypercortisolism and Corticotropin Releasing Hormone, Proc. Natl. Acad. Sci,
USA, 97:325-330.
403.
Franchimont D., Galon J., Gadina M., Visconti R., Zhou Y., Aringer M., Frucht DM., Chrousos G.P., O’Shea JJ.,
(2000) Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-induced
Stat-4 Phosphorylation in T Lymphocytes, J. Immunol, Feb 15; 164(4):1768-74.
404.
Kanik S., Chrousos G.P., Schumacher H. R, Crane M L., Yarboro C H., Wilder R L., (2000), ACTH, Glucocorticoid
and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid Arthritis: Relations with Indices of
Inflammation, J. Clinical Endocrinol. Metab. 85: 1461-1466
405.
Vgontzas, A.N., Papanicolaou, D. A., Bixler, E. O., Hopper, K., Lotsikas, A., Kales, A., Chrousos G.P. (2000),
Sleep Apnea and Daytime Sleepiness and Fatigue: Relations With Visceral Obesity, Insulin Resistance, and
Hypercytokinemia, J. Clin. Endocrinol. Metab., 85:1151-1158.
406.
Pathomvanich, A., Merke, D.P., Chrousos G.P., (2000) Early Puberty: A Cautionary Tale (Commentary); Pediatrics,
105:115-116.
407.
Torpy D.J., Papanicolaou D.A., Lotsikas A. J., Wilder R.L., Chrousos, G.P., Pillemer S.R., (2000) Responses of the
Sympathetic Nervous System and the Hypothalamic-Putuitary-Adrenal Axis to Interleukin-6 in fibromyalgia,
Arthritis & Rheumatism ; 43 (4): 872-880.
408.
Deuster P.A., Petrides J.S., Singh A., Chrousos G.P., Poth M.L., (2000) Endocrine Response to High-Intensity
Exercise: Dose-Dependent Effects of Dexamethasone, J. of Clinical Endocrinology and Metab., 85:1066-1073.
409.
Hsin L-W, Webster E.L., Chrousos G.P., Gold P.W., Eckelman W.C., Contoreggi C., Rice K.C., (2000) Synthesis
and Biological Activity of Fluoro-Substituted Pyrrolo [2,3-d]pyrimidines: the Development of Potential Positron
Emission Tomography Imaging Agents for Corticotropin- Releasing Hormone type 1 Receptor, Bioorganic &
Medicinal Chemistry Letters 10:707-710.
35
George P. Chrousos, M.D.
410.
Kanik K.S., Chrousos G.P., Schumacher H.R., Crane M.L., Yarboro C.H., Wilder R.L., (2000)
Adrenocorticotrophin, Glucocorticoid, and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid
Arthritis: Relations with Indices of Inflammation, J. of Clinical Endocrinology and Metab., 85:1461-1466.
411.
Bornstein, S.R., Asab, M. A., Glasow, A., Path, G., Hauner, H., Tsokos, M., Chrousos G.P., Scherbaum, W. A.,
(2000) Immunohistochemical and Ultrastructural Localization of Leptin and Leptin Receptor in Human White
Adipose Tissue and Differentiating Human Adipose Cells in Primary Culture, Diabetes, 49:532-538.
412.
Willenberg, H.S., Bornstein, S.R., Hiroi, N., Path, G., Goretzki, P.E., Scherbaum, W.A., Chrousos G.P., (2000)
Effects of a Novel Corticotropin-Releasing -Hormone Receptor Type I Antagonist on Human Adrenal Function,
Molec. Psychiatry., 5:137-141.
413.
Habib K.E., Weld K.P., Rice K.C., Pushkas J., Champoux M., Listwak S., Webster E.L., Atkinson A.,Schulkin J.,
Contoreggi C., Chrousos G.P., McCann S.M., Suomi S.J., Higley J.D., Gold P.W (2000) Oral Administration of a
CRH Receptor Antagonist Significantly Attenuates Behavioral, Neuroendocrine, and Autonomic Responses to
Stress in Primates, Proc. Ntl. Acad. Sci. USA., 10:1073-1079.
414.
Berga, S.L., Loucks-Daniels, T.L., Adler, L.J., Chrousos, G.P., Cameron, J.L., Matthews, K.A., Marcus, M.D.
(2000) Cerebrospinal Fluid Levels of Corticotropin-Releasing Hormone in Women with Functional Hypothalamic
Amenorrhea, Am J Obstet Gynecol, 182:776-784.
415.
Hsin L-W, Webster E.L., Chrousos G.P., Gold P.W., Eckelman W.C., Contoreggi C., Rice K.C., (2000) Synthesis of
[3H] LWH-154: a Potent Radioligand for Corticotropin-Releasing Hormone Type 1 Receptor, J. Labeled
Compounds and Pharmaceuticals, 43:899-908.
416.
Bornstein, S.R., Wolkersdorfer, G.W., Preas, H.L., Chrousos G.P., Suffredini, A.F., (2000) Brief Report: Plasma
Dehydroepiandrosterone (DHEA) Levels During Acute Experimental Endotoxemia and Antiinflammatory Therapy
in Humans, Critical Care Med, 28(6):2103-2106.
417.
Nawab, S.S., Miller, C.S., Dale, J.K., Greenberg, B.D., Friedman, T.C., Chrousos, G.P., Straus, S.E.,Rosenthal, N.E.
(2000) Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry
Research 95:67-74.
418.
Doppman, J.L., Chrousos, G.P., Papanicolaou, D.A., Stratakis, C.A., Alexander, H.R., Nieman, L.K. (2000)
Adrenocorticotropin-independent Macronodular Adrenal Hyperplasia: An Uncommon Cause of Primary Adrenal
Hypercortisolism. Radiology, 216(3):797-802.
419.
Bottner, A., Haidan, A., Eisenhofer, G., Kristensen, K., Castle, A.L., Scherbaum, W.A., Schneider, H., Chrousos,
G.P., Bornstein, S.R. (2000) Increased Body Fat mass and Suppression of Circulating Leptin Levels in Response to
Hypersecretion of Epinephrine in Phenylethanolamine-N-Methyltransferase (PNMT)-Overexpressing Mice.
Endocrinology, 141(11):4239-4246.
420.
Merke, D.P., Chrousos, G.P., Eisenhofer, G., Weise, M., Keil, M.F., Rogol, A.D., Van Wyk, J.J., Bornstein, S.R.
(2000) Adrenomedullary Dysplasia and Hypofunction in Patients with Classic 21-Hydroxylase Deficiency. N Engl
J Med. 343(19):1362-1368.
421.
Huang, S.C., Koch, C.A., Vortmeyer, A.O., Pack, S.D., Lichtenauer, U.D., Mannan, P., Lubensky, I.A., Chrousos,
G.P., Gagel, R.F., Pacak, K., Zhuang, Z. (2000) Duplication of the Mutant RET Allele in Trisomy 10 or Loss of the
Wild-Type Allele in Multiple Endocrine Neoplasia Type 2-associated Pheochromocytomas. Cancer Research.
60:6223-6226.
422.
Franchimont, E., Bouma, G., Galon, J., Wolkersdorfer, G.W., Haidan, A., Chrousos, G.P, Bornstein, S.R.(2000)
Adrenal Cortical Activation in Murine Colitis. Gastroenterology, 119:1560-1568.
423.
Bornstein, S.R., Tian, H, Haidan, A., Bottner, A., Hiroi, N., Eisenhofer, G., McCann, S.M., Chrousos,.P., RofflerTarlov, S. (2000) Deletion of Tyrosine Hydroxylase Gene Reveals Functional Interdependence of Adrenocortical
36
George P. Chrousos, M.D.
and Chromaffin Cell System in Vivo., PNAS, 97:14742-14747.
424.
Longui, C.A., Vottero, A., Adamson, P.C., Cole, D.E., Kino, T., Monte, O., Chrousos, G.P. (2000) Low
Glucocorticoid Receptor Alpha/beta Ratio in T-cell Lymphoblastic Leukemia. Horm. Metab. Res., 32:401-406.
425.
Garcia-Borreguero, D., Wehr, T.A., Larrosa, O., Granizo, J.J., Hardwick, D., Chrousos, G.P., and Friedman, T.C
(2000) Glucocorticoid Replacement is Permissive for Rapid Eye Movement Sleep and Sleep Consolidation in
Patients with Adrenal Insufficiency. J. Clin. Endocrinol. Metab. 85:4201-4206.
426.
Hope, P.J., Tumbull, H., Farr, S., Morley, J.E., Rice, K.C., Chrousos, G.P., Torpy, D.J., Wittert, G.H. (2000)
Peripheral Administration of CRF and Urocortin: Effects on Food Intake and the HPA axis in the Marsupial
Sminthopsis crassicaudata. Peptides, 21:669-677.
427.
Mitsiades, N., Poulaki, V., Tseleni-Balafouta, S., Chrousos, G.P., Koutras, D.A. (2000) Fas Ligand Expression in
Thyroid Follicular Cells from Patients with Thionamide-treated Graves’ Disease. Thyroid, 10:527-532.
428.
Hauk PJ, Hamid QA, Chrousos GP, Leung DY (2000) Induction of Corticosteroid Insensitivity by Microbial
Superantigens. J All Clin Immunol 105: 782-787
429.
Merke, D.P., Cho, D., Calis, K.A., Keil, M.F., Chrousos, G.P. (2001) Hydrocortisone Suspension and
Hydrocortisone Tablets Are not Bioequivalent in the Treatment of Children with Congenital Adrenal Hyperplasia.J.
Clin. Endocrinol. Metab., 86: 441-445.
430.
Tian X., Hsin L-W., Webster E. L., Contoreggi C., Chrousos G P., Gold P. W., Habib K., Ayala A., Eckelman
W.C., Jacobson, A.E. Rice K.C.(2001) The Development of a Potential Single Photon Emission Computed
Tomography (SPECT) Imaging Agent for the Corticotropin-releasing Hormone Receptor Type 1. Bioorganic &
Medicinal Chemistry Letters, 11: 331-333
431.
Vgontzas, A.N., Bixler, E.O, Wittman, A.M., Zachman, K., Lin, H.M., Vela-Bueno, A., Kales, A., Chrousos, G.P.
(2001) Middle-Aged Men Show Higher Sensitivity of Their Sleep to the Arousing Effects of Corticotropin-releasing
Hormone than Younger Men: Clinical Implications., J. Clin. Endocrinol. Metab. 86: 1489-95
432.
Vgontzas, A.N., Legro, R.S., Bixler, E.O., Grayev, A., Kales, A., Chrousos, G.P. (2001) Polycystic Ovary
Syndrome is Associated with Obstructive Sleep Apnea and Daytime Sleepiness: Role of Insulin Resistance.J. Clin.
Endocrinol. Metab.86: 517-520.
433.
Strickland I., Kisich K., Hauk P.J., Vottero A., Chrousos G.P., Klemm D.J., Leung D.Y.M. (2001) High
Constitutive Glucocorticoid Receptor Beta in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate
of Cell Death in Response to Corticosteroids. J. Exp. Med.193: 585-593
434.
Path, G., , S.R., Gurniak, M., Chrousos, G.P., Scherbaum, W.A., Hauner, H. (2001) Human Breast Adipocytes
Express Interleukin (IL)-6 and its Receptor System: Increased IL-6 Production by beta-Adrenergic Activation and
Effects of IL-6 on Adipocyte Function. J Clin Endocrinol. Metab.86: 2281-2288
435.
Erickson K., Thorsen P., Chrousos G., Grigoriadis D.E., Khongsaly O., McGregor J., Schulkin J. (2001) Preterm
Birth: Associated Neuroendocrine, Medical, and Behavioral Risk Factors. J. Clin. Endocrinol. Metab.86: 2544-2552
436.
Hiroi, N., Chrousos, G.P., Abu-Asab, M., Bonat, S., Lafferty, A., White, A., Bornstein, S.R. (2001) AdrenocorticalPituitary Hybrid Tumor Causing Cushing’s Syndrome. J. Clin. Endocrinol. Metab.86: 2631-2637
437.
Cizza, G., Dorn, L.D., Lotsikas, A., Sereika, S., Rotenstein, D., Chrousos, G.P. (2001) Circulating Plasma Leptin
and IGF-1 Levels in Girls with Premature Adrenarche: Potential Implications of a Preliminary Study. Hormone and
Metabolic Research 33:148-143
438.
Kraft M., Hamid O., Chrousos G., Martin R.J., Leung D. (2001) Decreased Steroid Responsiveness at Night: Is the
Macrophage Responsible? Am. J. Resp. Crit. Care Med. 163: 1219-1225
37
George P. Chrousos, M.D.
439.
Poulaki, V., Mitsiades, N., Mastorakos, G., Caspi, R.R., Chrousos, G.P., and Bouzas, E. (2001) Fas/Fas ligandassociated Apoptosis in Experimental Autoimmune Uveoretinitis in Rodents: Role of Proinflammatory
Corticotropin-releasing Hormone. Exp. Eye Res.72:623-629
440.
Schneider, R., Bornstein, S.R., Chrousos, G.P., Boxberger, S., Ehniger, G., Breidert, M. (2001) Leptin mediates a
proliferative response in human gastric mucosa cells with functional receptor. Horm Metab Res. 33(1):1-6.
441.
Bernardini, R., Johnson, E.O., Kamilaris, T., Chiarenza, A., Cantarella, G., Calogero, A.E., Lempereur , L.,
Chrousos, G.P., Giuffrida, R., Gold, P.W. (2001) Increased ACTH and cortisol secretion after interleukin-alpha
injection in the common marmoset (Callithrix jacchus jacchus). Life Sci. 68(14):1657- 65.
442.
Baker, D. G., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Zoumakis, E., Dashevsky, B. A., Chrousos, G. P., and
Geracioti, T. D.(2001) Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder.
Neuroimmunomodulation. 9(4), 209-217.
443.
Kuperman H., Damiani D., Chrousos G.P., Dichtchenian V., Chrousos G.P., Della Manna T., Filho V. O., Setian N.
(2001) Evaluation of the Hypothalamic-pituitary-adrenal Axis in Children with Leukemia before and after 7 Weeks
of High Dose Glucocorticoid Therapy. J. Clin. Endocrinol. Metab. 86: 2993-2996
444.
Kraft M. Hamid Q. Chrousos G.P., Martin RJ, Leung DY. (2001) Decreased steroid responsiveness at night in
nocturnal asthma. Is the macrophage responsible? Am J Respir Crit Care Med. 163: 1219-25.
445.
Ghizzoni L. Barreca A, Mastorakos G. Furlini M., Vottero A. Ferrari B., Chrousos GP, Bernasconi S. (2001) Leptin
inhibits steroid biosynthesis by human granulosa-lutein cells. Horm Metab Res. 33 : 323-8.
446.
Vgontzas A., Bixler E.O., Lin H.-M., Prolo P., Mastorakos G., Vela-Bueno A., Kales A., Chrousos G.P.(2001)
Chronic Insomnia is Associated with Nyctohemeral Activation of the Hypothalamic-pituitary-adrenal Axis. J. Clin.
Endocrinol. Metab.86: 3787-3794
447.
Hiroi N., Wong M.L., Licinio J., Park C., Gold P.W., Chrousos G.P., Bornstein S.R. (2001) Expression of
Corticotropin Releasing Hormone Receptors Type 1 and Type 2 mRNA in Suicide Victims and Controls. Mol.
Psychiatry 6: 540-546
448.
Kohno M., Kawahito Y., Tsubouchi Y., Hashiramoto A., Yamada R., Inoue K., Kusaka Y., Kubo T., Elenkov I. J,
Chrousos G.P., Kondo M., and Sano H. (2001) Urocortin Expression in Synovium of Patients with Rheumatoid
Arthritis and Osteoarthritis: Relation to Inflammatory Activity. J. Clin. Endocrinol. Metab.86:4344-4352
449.
Makrigiannakis A., Zoumakis E., Kalantaridou S., Coutifaris C., Coukos, G., Rice K., Gravanis, A. and Chrousos G.
P. (2001) Corticotropin-releasing Hormone (CRH) Promotes Blastocyst Implantation and Early Maternal Tolerance.
Nature Immunology 2:1018-24
450.
Abad V., Chrousos G.P., Reynolds J., Nieman L., Hill S., Weinstein R., Leong G.(2001) Glucocorticoid Excess
during Adolescence Leads to a Major, Persistent Deficit in Bone Mass and Increase in Central Body Fat. J. Bone
and Min. Research. 16; 1879-85
451.
Elenkov I. J., Wilder R. L., Bakalov V. K., Link A.A., Dimitrov M., Fisher S., Crane M., Kanik K., Chrousos G. P.
(2001) Interleukin 12, Tumor Necrosis Factor-alpha and Hormonal Changes during Late Pregnancy and Early
Postpartum: Implications for Autoimmune Disease Activity during These Times. J. Clin. Endocrinol. Metab. 86:
4933-8
452.
Kino T., Stauber R.H., Resau J. H., Pavlakis, G., Chrousos G. P. (2001) Pathologic Human Glucocorticoid Receptor
(GR) Mutant Has a Transdominant Negative Effect on the Wild Type GR by Inhibiting Its Translocation into the
Nucleus: Importance of the Ligand-binding Domain for Intracellular GR Trafficking. J. Clin. Endocrinol. Metab. 86:
5600-8
453.
Koch, C.A., Vortmeyer, A.O., Huang, S.C., Moley, J.F., Azumi, N., Chrousos, G.P., Gagel, R.F., Zhuang, S., Pacak,
K. (2001) Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid
38
George P. Chrousos, M.D.
carcinoma. Oncogene 20:7809-11
454.
Maurer M, Trajanoski Z, Hiroi N, Frey G, Galom J, Willenberg HS Gold PW, Chrousos GP, Scherbaum WA,
Bornstein SR (2001) Differential gene expression profile of glucocorticoids, testosterone and
dehydroepiandrosterone in human cells. Hormone Metab. Res. 33:691-695
455.
Galon J., Franchimont D., Hiroi N., Boettner A., Ehrhart-Bornstein M., Chrousos G.P., Bornstein S.(2002) Gene
Profiling Reveals Unknown Enhancing and Suppressive Actions of Glucocorticoids on Immune Cells. FASEB J.16:
61-71
456.
Kino T., Slobodskaya O., Pavlakis, N. and Chrousos G. P. (2002) Nuclear Receptor Coactivator p160 Proteins
Enhance the Human Immunodeficiency Virus (HIV) Type 1 Long Terminal Repeat Promoter by Bridging Promoter
Bound Factors and the Tat/pTEFb Complex. J. Biol. Chem., on-line release 11/01/01 277(4):2396-405.
457.
Hsin L-W., Tian X., Webster E.L., Coop A., Caldwell T. C., Jacobson A.E., Chrousos G.P., Gold P.W., Habib,
K.H., Ayala A., Eckelman W.C., Contoreggi C., Rice. K. (2002) CRHR1 Receptor Binding and Lipophilicity of
Pyrrolopyrimidines, Potential Nonpeptide Corticotropin-releasing Hormone Type 1 Receptor Antagonists. Biorg.
Med. Chem. 10:175-183
458.
Koch CA, Huang SC, Zhuang Z, Stolle C., Azumi N, Chrousos GP, Vortmeyer AO, Pacak K (2002) Somatic VHL
Gene Deletion and Point Mutation in MEN 2A-associated Pheochromocytoma. Oncogene 21:479-482
459.
Franchimont, D., Galon, J., Vacchio, M.S., Fan, S., Visconti, R., Frucht, D.M., Geenen, V., Chrousos, G.P.,
Ashwell, J.D., O’Shea, J.J. (2002) Positive Effects of Glucocorticoids on T Cell Development and Function by
Upregulation of Interleukin-7 Receptor J. Immunol,.168: 2212-2218
460.
Koch C A, Vorrtmeyer A O, Diallo R, Poremba C, Giordano T J, Sanders D, Bornstein S R, Chrousos G P, and
Pacak K. (2002) Survivin: A Novel Neuroendocrine Marker for Pheochromocytoma. Eur. J. Endocrinol 146: 381388
461.
Mendonca B B, Leite M V, deCastro M, Kino T, Elias L L, Bachega T A S, Billerbeck A E Arnhold I A J P,
Chrousos G P, Latronico A C (2002) Female Pseudohermaphrodotism Caused by A Novel Homozygous Missence
Mutation of the Glucocorticoid Receptor Gene. J. Clin. Endocrinol.. Metab. 87:1805-1809
462.
Meduri G. U., Tolley E. A., Chrousos G. P. and Stentz F. (2002) Prolonged Methylprednisolone Treatment
Suppresses Systemic Inflammation in Patients with Unresolving ARDS: Evidence for Inadequate Endogenous
Glucocorticoid Secretion and Inflammation-induced Immune Cell Resistance to Glucocorticoids. Am. J. Resp. Crit.
Care Med. 165:983-991
463.
Sato H., Nagashima Y., Chrousos GP, Ichihashi M., Fusanaka Y. ( 2002) The Expression of Corticotropin-releasing
Hormone in Melanoma. Pigment Cell Res. 15:98-103
464.
Charmandari E, Weise M, Bornstein S R, Eisenhofer G, Keil M F, Chrousos G, Merke D P. (2002) Children with
Classic Congenital Adrenal Hyperplasia Have Elevated Serum Leptin Concentrations and Insulin Resistance.J. Clin.
Endocrinol. Metab. 87: 2139-2143
465.
Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvega S, Trimarchi F, Ehrhart- Bornstein M
(2002) Adenoviral Vectors Can Impair Adrenocortical Steroidogenesis: Clinical Implications for Natural Infections
and Gene Therapy. Proc. Natl Acad. Sci. USA 99:7484-7489
466.
Vottero A., Kino T., Combe H., Lecomte P., and Chrousos G.P. (2002) A Novel, C-terminal Dominant Negative
Mutation of the Glucocorticoid Receptor Causes Familial Glucocorticoid Resistance through Abnormal Interactions
with p160 Steroid Receptor Coactivators. J. Clin. Endocrinol. Metab. 87: 2658-2667
467.
Greiner E., Atkinson A. J., Ayala A., Chrousos G. P., Contoreggi C., Eckelman W. C., Gold P.W., Habib K.,
Jacobson A.E., Webster E.,L., Rice K.C. (2002) Synthesis of Doubly Labelled 13C Antalarmin Isotopomers for
Pharmakokinetic Studies. J. Lab. Cpds and Radiopharmaceuticals 45:637-645
39
George P. Chrousos, M.D.
468.
Charmandari E, Eisenhofer G, Mehlinger S, Carlson A, Wesley R, Keil M, Chrousos GP, New MI, Merke DP.
(2002) Adrenomedullary Function May Predict Phenotype and Genotype in Classic 21-Hydroxylase Deficiency. J
Clin Endocrinol Metab. 87: 3031-3037
469.
Young IR, Chan EC, Smith R, Chrousos GP, Veldhuis JD, Canny BJ (2002) The Effect of Antalarmin, a Novel
Corticotropin Releasing Hormone Antagonist on the Dynamic Function of the Preterm Ovine Fetal Hypothalamicpituitary-adrenal axis. Neuroendocrinology 76:47-54
470.
Webster E L, Barrientos R M, Contoreggi C, Isaac M G, Ligier S, Habib K, Chrousos G P, McCarthy E F, Rice K C,
Gold PW, Sternberg E M. (2002) Corticotropin-releasing Hormone (CRH) Antagonist Attenuattes Adjuvantinduced Arthritis: Evidence Supporting Major Role for CRH in Peripheral Inflammation. J. Rheumatol. 29: 12521261.
471.
Gabry K.E., Chrousos G.P., Rice K.C., Mostafa R.M., Sternberg E., Negrao A.B., Webster E.L., McCann S.M.,
Gold P.W. (2002) Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of
drugs. Molec. Psych. 7:474-483.
472.
Vgontzas A N, Zoumakis M, Papanicolaou D A, Bixler E , Prolo P, Lin H-M, Vela-Bueno A, Kales M d, and
Chrousos GP. (2002) Chronic Insomnia is Associated with a Shift of IL-6 and TNFa Secretion from Nighttme to
Daytime. Metabolism, 29:1252-1261
473.
Koch CA, Mauro D, Walther MM, Linehan,WM, Vortmeyer AO, Jaffe R, Pacak K, Chrousos GP, Zhuang Z,
Lubensky IA (2002) Pheochromocytoma in VHL Disease: Distinct Histopathologic Phenotype Compared to
Pheochromocytoma in Multiple Endocrine Neoplasia Type 2. Endocrine Pathology 13:17-27
474.
Mansky P. J., Liewehr D. J., Steinberg S. M., Chrousos G. P., Avila N. A., Long L., Bernstein D., Mackall C. L.,
Hawkins D. S., and Helman L. J. (2002) Treatment of Metastatic Osteosarcoma with the Somatostatin Analog
OncoLar: Significant Reduction of IGF-1 Serum Levels. J. Ped. Hematol. Oncol. 24:440-446
475.
Pacak K, Tjurmina O, Palkovits M, Goldstein DS, Koch CA, Hoff T., Chrousos GP (2002) Chronic
Hypercortisolemia Inhibits Dopaminergic Activity in the Nucleus Accumbens but not the Prefrontal Cortex: An in
Vivo Microdialysis Study. Neuroendocrinology 76:148-157
476.
Kino T, Gragerov A, Slobodskaya O, Tsopanomihalu-Nglotsou M, Chrousos GP, and Pavlakis G (2002) Human
Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and
Glucocorticoid-responsive Promoters by Binding Directly to p300/CBP Coactivators. J. Virol. 76:9724-9734
477.
Kino T. Tsukamoto M., and Chrousos GP (2002) Transcription Factor TFIIH Components Enhance the GR
Coactivator Activity but Not the Cell Cycle –arresting Activity of the Human Immunodeficiency Virus Type-1
Protein Vpr. Bioch. Biophys. Res. Commun. 298: 17-23
478.
Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos GP, and Kino T (2002) Human Immunodeficiency Type-1 (HIV1) Protein Vpr Suppresses Interleukin-12 Production from Human Monocytes by Enhancing Glucocorticoid Action:
Potential Implications of Vpr Coactivator Activity for the Innate and Cellular Immunity Deficits Observed in HIV-1
Infection. J Immunol 169:6361-6368
479.
Skalkidou A, Petridou E, Papathoma E, Salvanos H, Chrousos GP, Trichopoulos D (2002) Birth Size and Neonatal
Levels of Major Components of the IGF System: Implication for Later Risk of Cancer. J Ped Endocrinol Metab. 15:
1479-1486
480.
Bader T, Zoumakis E, Friedberg M, Hiroi N, Chrousos GP, Hochberg Z (2002) Human Adipose Tissue under in
Vitro Inhibition of 11beta-Hydroxysteroid Dehydrogenase Type 1: Differentiation and Metabolism Changes. Horm
Metab Res 34: 752-757
481.
Wolkersdorfer GW, Bornstein SR, Higginbotham JN, Hiroi N, Vaquero JJ, Green MV, Blaese RM, Aguilera G,
Chrousos GP, Bornstein SR (2002) A Novel Approach Using Transcomplementing Adenoviral Vectors for Gene
40
George P. Chrousos, M.D.
Therapy of Adrenocortical Cancer. Horm Metabol Res 34: 279-287
482.
Kino T and Chrousos GP (2003) Tumor Necrosis Factor–alpha- and Fas-associated FLASH Inhibits Transcriptional
Acivity of the Glucocorticoid Receptor by Binding to and Interfering with its Interaction with p160 Type Nuclear
Receptor Coactivators. J Biol Chem 278: 3023-3029
483.
Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z, Chrousos G, Trichopoulos D (2003)
Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case Control Study in Greece. J Clin
Endocrinol Metab 88: 983-997
484.
Tiosano D, Eisenstadt I, Militianu D, Chrousos GP , Hochberg Z (2003) 11-Beta- Hydroxysteroid Dehydrogenase
Activity in Hypothalamic Obesity. J Clin Endocrinol Metab 88: 379-384
485.
Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z (2003) Modulation of 11-BetaHydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers. J
Clin Endocrinol Metab 88: 385- 393
486.
Marini JC, Hopkins E, Glorieux FH, Chrousos GP, Reynolds JC, Gundberg CM, Reing CM (2003) Positive Linear
Growth and Bone Responses to Growth Hormone Treatment in Children with Types III and IV Osteogenesis
Imperfecta: High Predicitive Value of the Carboxyterminal Propeptide of Type I Procollagen. J Bone Miner Res 18:
237-243
487.
Vottero A, Kimci-Sarfaty C, Kratzsch J, Chrousos GP, Hochberg Z. (2003) Transcriptional and Translational
Regulation of the Splicing Isoforms of the Growth Hormone Receptor by Glucocorticoids. Horm Metab. Res. 35: 712
488.
Vottero A, Kimcy-Sarfaty C, Kratzsch J, Miller G, Lafferty A, Chrousos GP, Hochberg Z. (2003) Relative
Abudance of Growth Hormone Receptor Isoforms in Rhesus Monkey Tissues and Human Transformed
Lymphocytes. Horm. Metab. Res. 35: 1-6
489.
Merke DP, Fields JD, Keil MF, Vaituzis C, Chrousos GP, Giedd JN (2003) Children with Classic Congenital
Adrenal Hyperplasia Have Decreased Amygdala Volume: Potential Prenatal and Postnatal Hormonal Effects. J.
Clin. Endocrinol. Metab 88: 1760-1765
490.
Vgontzas AN, Zoumakis M, Bixler EO, Lin H-M, Prolo P, Vela-Bueno A, Kales A and Chrousos GP (2003)
Impaired Nighttime Sleep Is Associated with Elevated Plasma IL-6 and Cortisol Levels in Healthy Old vs. Young
Adults: Physiologic and Therapeutic Implications. J Clin Endocrinol Metab 88: 2087-2095
491.
Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalou M, Wan Y. and Chrousos GP (2003) Protein 14-3-3
sigma Interacts with and Favors Cytoplasmic Subcellular Localization of the Glucocorticoid Receptor, Acting as a
Negative Regulator of the Glucocorticoid Signaling Pathway. J. Biol. Chem. 252:32-44
492.
Alesci S, De Martino M, Mirani M, Benvega S, Trimarchi F, Kino T, and Chrousos GP (2003) L-Carnitine: A
Nutritional Modulator of Glucocorticoid Receptor Functions. FASEB J. (Electronic release June 17). 17(11):1553-5
493.
Vozarova B, Weyer C, Snitker S, Gautier J-F, Cizza G, Chrousos G, Ravussin E, and Tataranni PA (2003) Effect of
Cortisol on Muscle Sympathetic Nerve Activity in Pima Indians and Caucasians. J Clin Endocrinol. Metab 88:
3218-26
494.
Jagoda, E., Contoreggi, C Lee MJ, Kao CHK , Szajak LP , Listwak, Gold PW, Chrousos GP, Greiner E,. Jacobson
AE, Rice KC and Eckelman W (2003) Autoradiographic Visualization of Corticotropin Releasing Hormone Type 1
Receptors with a Nonpeptide Ligand: Synthesis of [ MJL-1-101-2. J Med Chem. 46:3559-3562
495.
Hiroi N, Kino T, Bassett M, Rainey WE, Phung M, Abu-Asab M, Fojo T, Briata P, Chrousos GP, Bornstein SR.
(2003) Pituitary Homeobox Factor 1, A Novel Transcription Factor in the Adrenal Regulating Steroid 11Beta hydroxylase. Horm Metab Res. 35: 273-8.
41
George P. Chrousos, M.D.
496.
Skalkidou A, Petridou E., Papathoma E, Salvanos H, Kedikoglou S., Chrousos G. and Trichopoulos D (2003)
Determinants and Consequences of Major Insulin-like Growth Factor Components among Full-term Neonates. Canc
Epidemiol Biomark Prev 12:860-865.
497.
Contoreggi C, Herning R.I, Na P, Gold PW, Chrousos GP, Negro PJ, Better W, and. Cadet JL (2003) Stress
Hormone Responses to Corticotropin–Releasing Hormone (CRH) in Substance Abusers without Severe Co-morbid
Psychiatric Disease. Biol Psychiatry 54: 873-878.
498.
De Martino M, Bhattachryya N, Alesci S, Fabbri A, Chrousos GP and Kino T (2004)The Glucocorticoid Receptor
(GR) and the Orphan Nuclear Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUPTFII) Interact with and Mutually Affect Each Other’s Transcriptional Activities: Implications for Intermediary
Metabolism. Molecular Endocrinol. 18:820-833.
499.
Kanaka-Gantenbein C, Kitsiou S, Mavrou A, Stamoyannou L, Kolialexi A, Kekou K, Liakopoulou M, Chrousos G
(2004) Tall Stature, Insulin Resistance, and Disturbed Behavior in a Girl with the Triple X Syndrome Harboring 3
SHOX Genes: Offspring of a Father with Mosaic Klinefelter Syndrome but with Two Maternal X Chromosomes.
Horm Res 61: 205-210.
500.
Weise M, Mehlinger S, Rawson E, Charmandari E, Eisenhoffer G, Yanovski J, Chrousos GP, Merke D. (2004)
Patients with Classic Congenital Adrenal Hyperplasia Have Decreased Epinephrine Reserve and Defective Glucose
Elevation in Response to High Intensity Exercise, J. Clin. Endocrinol. Metab. 89: 591-597.
501.
Mantzoros C, Petridou E, Dessypris N, Chavelas H, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C,
Spanos E, Chrousos G, Trichopoulos D (2004) Adiponectin and Breast Cancer Risk J Clin Endocrinol Metab 89:
1102-7.
502.
Ward AM, Syddall HE, Wood PJ, Chrousos GP, Phillips DI (2004) Fetal Programming of the Hypothalamicpituitary-adrenal (HPA) Axis: Low Birth Weight and Central HPA Regulation. J Clin Endocrinol Metab 89: 122733.
503.
Charmandari E, Kino T, Souvatzoglou E, Vottero A, Bhattacharayya N, and Chrousos GP (2004) Natural
Glucocorticoid Receptor Mutants Causing Glucocorticoid Resistance: Molecular Genotype, Genetic Transmission
and Clinical Phenotype. J. Clin. Endocrinol. Metab.89: 1939-1949.
504.
Charmandari E, Merke D, Negro PJ, Keil M, , Martinez PE, Haim A, Gold PW and Chrousos GP (2004)
Endocrinologic and Psychologic Evaluation of 21-Hydroxylase Deficiency Carriers and Matched Normal Subjects:
Evidence for Physical and/or Psychologic Vulnerability to Stress , J Clin Endocrinol Metab 89:2228-2236.
505.
Vgontzas A, Zoumakis E, Bixler EO, Lin H-M, Follett H, Kales A and Chrousos GP (2004) Adverse Effects of
Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines. J Clin Endocrinol Metab 89:
2119-2126.
506.
Yuhas Y, Weizman A, Chrousos GP, Ovadia H, Ashkenazi S. (2004) Involvement of the Neuropeptide
Corticotropin-releasing Hormone in an Animal Model of Shigella-related Seizures. J Neuroimmunol. 153: 36-39.
507.
Weise M, Drinkard B Mehlinger SL, Eisenhofer G, Chrousos GP and Merke DP (2004) Stress Dose of
Hydrocortisone is not Beneficial in Patients with Classic Congenital Adrenal Hyperplasia Undergoing Short-term
High-intensity Exercise. J. Clin. Endocrinol. Metab. 89: 3679-3684.
508.
Kalantaridou SN, Naka KK, Papanikolaou E, Kazakos N, Kravariti M, Calis KA, Paraskevaidis EA, Sideris DA,
Tsatsoulis A, Chrousos GP, and Michalis LK (2004) Impaired Endothelial Function in Young Women with
Premature Ovarian Failure: Normalization with Hormone Therapy .J Clin Endocrinol Metab 89: 3907-3913.
509.
Schulpis KH, Papassotiriou I, Vounatsou M, Karikas GA, Tsakiris S, Chrousos GP. (2004) Morning Preprandial
Plasma Ghrelin and Catecholamine Concentrations in Patients with Phenylketonuria and Normal Controls: Evidence
for Catecholamine-mediated Ghrelin Regulation. J Clin Endocrinol Metab 89:3983-7.
42
George P. Chrousos, M.D.
510.
Vgontzas AN, Zoumakis E, Lin H-M, Bixler EO, Chrousos GP (2004) Marked Decrease of Sleepiness in Patients
with Sleep Apnea by Etanercept, a TNF alphaAntagonist. J. Clin. Endocrinol. Metab. 89: 4409-13.
511.
Charmandari E, Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T.Related Articles,
Links (2005) The Human Glucocorticoid Receptor (hGR) {beta} Isoform Suppresses the Transcriptional Activity of
hGR{alpha} by Interfering with Formation of Active Coactivator Complexes. Mol Endocrinol. 19: 52-64.
512.
Glass JM, Lyden AK, Petzke F, Stein P, Whalen G, Ambrose K, Chrousos G, Clauw DJ. (2004) The effect of brief
exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals. J Psychosom Res.
57: 391-398.
513.
Ayala AR, Pushkas J, Higley JD, Ronsaville D, Gold PW, Chrousos GP, Pacak K, Calis KA, Gerald M, Lindell S,
Rice KC, Cizza C (2004) Behavioral, Adrenal and Sympathetic Responses to Long Term Administration of an Oral
Corticotropin-releasing Hormone Receptor Antagonist in a Primate Stress Paradigm. J Clin Endocrinol Metab 89:
5729-5737.
514.
Tiulpakov A, Rubtsov P, Dedov I, Peterkova V, Bezlepkina O, Chrousos GP, Hochberg Z J (2005) A Novel Cterminal Growth Hormone Receptor (GHR) Mutation Results in Impaired GHR-Stat5 but Normal Stat3 Signaling. J
Clin Endocrinol Metab 90: 542-547.
515.
Bloch M, Rubinow D, Schmidt PJ, Lotsikas A, Chrousos GP, Cizza G (2005) Cortisol Response to oCRH in a
Model of Pregnancy and Parturition in Euthymic Women with and without a History of Postpartum Depression. J
Clin Endocrinol Metab 90: 695-699.
516.
Mantzoros C, Petridou E, Alexe DE, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Shetty E, Gavrila A,
Kedikoglou S, Chrousos G, Trichopoulos, D (2004) Serum Adiponectin Concentrations in Relation to Maternal and
Perinatal Characteristics in Newborns. Eur J Endocrinol 151:741-746.
517.
Kino T, Ichijo T, Chrousos G (2004) FLASH Interacts with p160 Coactivator Subtypes and Differentially
Suppresses Transcriptional Activity of Steroid Hormone Receptors. J Steroid Biochem and Molec Biol. 92: 357-363.
518.
Kino T, Ichijo T, Charmandari E, De Martino M, Outas T and Chrousos GP (2005) The Human Immunodeficiency
Virus Type-1 (HIV-1) Accessory Protein Vpr Inhibits the Effect of Insulin on the Foxo Subfamily of the Forkhead
Transcription Factors by Interfering with its Binding to 14-3-3 Proteins: Potential Clinical Implications Regarding
the Insulin Resistance of HIV-1-infected Patients. Diabetes 2005 Jan; 54(1): 23-31.
519.
Lycopoulou L, Mamoulakis C, Hantzi E, Demetriadis D, Antypas S, Giannaki M, Bakoula C, Chrousos G,
Papassotiriou I. (2005) Serum Amyloid A Protein Levels as a Possible Aid in the Diagnosis of Acute Appendicitis in
Children. Clin Chem Lab Med. 43(1): 49-53.
520.
Cizza G, Romagni P, Lotsikas A, Lam G, Rosenthal NE, Chrousos GP. (2005) Plasma leptin in men and
with seasonal affective disorder and in healthy matched controls. Horm Metab Res 37(1): 45-48.
521.
Alesci S, Martinez P,Kelkar S, Ilias I, Ronsaville DS, Listwak SJ,.Ayala AR, Licinio J, Gold H, Kling MA,
Chrousos GP, and Gold PW(2005) Major Depression Is Associated with Significant Diurnal elevations In Plasma
IL-6 Levels, A Shift of Its Circadian Rhythm, and loss of physiologic complexity in its secretion: Clinical
Implications. J Clin Endocrinol Metab 90:2522-2530.
522.
Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Cohen-Erwin R, Chrousos GP and
Pavlakis GN (2005) Vpr Protein of Human Immunodeficiency Virus Type 1 Binds to 14-3-3 Proteins and Facilitates
Complex Formation with Cdc25C: Implications for Cell Cycle Arrest. J Virol 79:2780-2787.
523.
Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou
S, Chrousos G, Trichopoulos D (2005). Neonatal leptin levels are strongly associated with female gender, birth
length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf).62(3):366-71.
524.
Merke DP, Giedd JN, Keil MF, Mehlinger SL, Wiggs E, Holzer S, Rawson E, Vaituzis AC, Stratakis
women
CA,
43
George P. Chrousos, M.D.
Chrousos GP. (2005) Children Experience Cognitive Decline Despite Reversal of Brain Atrophy One Year
Following Resolution of Cushing Syndrome. J Clin Endocrinol Metab. 90:2531-2536.
525.
Fruchter O, Kino T, Zoumakis E, Alesci S, De Martino, M, Chrousos G, Hochberg, Z.(2005) The Human
Glucocorticoid Receptor (GR) Isoform  Differentially Suppresses GR-induced Transactivation Stimulated by
Synthetic Glucocorticoids. J Clin Endocrinol Metab 90:3505-3509.
526.
Charnandari E, Raji A, Kino T, Ichijo T, Tiulpakov A, Zachman K, Chrousos GP (2005) A Novel Point Mutation in
the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized
Glucocorticoid Resistance: The Importance of C-terminus of hGR LBD in Conferring Transactivational Activity. J
Clin Endocrinol Metab 90: 3696-3705.
527.
Rubinow DR, Roca CA, Schmidt PJ, Danaceau MA, Putnam K, Cizza G, Chrousos G, Nieman L.
Testosterone Suppression of CRH-Stimulated Cortisol in Men. Neuropsychopharmacology 30:1906-1912.
528.
Margeli A, Skenderi K, Tsironi M, Hantzi E, Matalas AL, Vrettou C, Kanavakis E, Chrousos G, Papassotiriou I.
Dramatic Elevations of Interleukin-6 and Acute Phase Reactants in Athletes Participating in the Ultradistance Foot
Race "Spartathlon": Severe Inflammation and Lipid and Lipoprotein Changes in Protracted Exercise. J Clin
Endocrinol Metab. 90: 3914-3918.
529.
Putnam K, Chrousos GP, Nieman LK, Rubinow DR. (2005) Sex-Related Differences in Stimulated HPA Axis
During Induced Gonadal Suppression. J Clin Endocrinol Metab. 90: 4224-4231.
530.
Gold PW, Wong M-L, Goldstein D, Gold H, Ronsaville D, Esler M, Alesci S, Masood A, Licinio J, Geraciotti TD,
Perini GI, DeBellis MD, Vgontzas AN, Charney DS, Chrousos GP, McCann SM and Kling MA (2005) Cardiac
Implications of Increased Arterial Entry and Reversible 24-h Central and Peripheral Norepinephrine Levels in
Melancholia. Proc Natl Acad of Sci USA.102: 8303-8308.
531.
Deuster PA, Faraday MM, Chrousos GP, Poth MA (2005) Effects of Dehydroepiandrosterone and Alprazolam on
Hypothalamic-Pituitary Responses to Exercise. J Clin Endocrinol Metab. 90:4777-4783.
532.
Manoli I, Hanh Le H, Alesci S, McFann KK, Su Y, Kino T, Chrousos GP, and Blackman MR (2005) Monoamine
Oxidase-A is a Major Target Gene for Glucocorticoids in Human Skeletal Muscle Cells: Induction of Gene and
Oxidative Activity and Relevance to Glucocorticoid- Mediated Myopathy. FASEB J 19: 1359-1361.
533.
Million M, Maillot C, Adelson DA, Nozu T, Gauthier A, Rivier J, Chrousos GP, Bayati A. Mattsson H, Tache Y.
(2005) Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female
rats. Peptides 26(7):1188-1195.
534.
Kravariti M, Naka KK, Kalantaridou SN, Kazakos N, Katsouras CS, Makrigiannakis A, Paraskevaidis EA, Chrousos
GP, Tsatsoulis A, Michalis LK. (2005) Predictors of Endothelial Dysfunction in Young Women with Polycystic
Ovary Syndrome. J Clin Endocrinol Metab. 90:5088-95.
535.
Johnson EO, Kamilaris TC, Calogero AE, Gold PW, Chrousos GP. (2005) Experimentally-induced hyperthyroidism
is associated with activation of the rat hypothalamic-pituitary-adrenal axis. Eur J Endocrinol. 153:177-185.
536.
Nishikawa T, Suematsu S, Saito J, Soyama A, Ito H, Kino T, Chrousos G (2005).Human renal mesangial cells
produce aldosterone in response to low-density lipoprotein (LDL).J Steroid Biochem Mol Biol. 96:309-316.
537.
Chrousos GP, Ghaly L, Shedden, A,. Iezzoni D, and Harris AG (2005) Effects of Mometasone Furoate Dry Powder
Inhaler and Beclomethasone Dipropionate Hydrofluroalkane and Chlorofluorocarbon on the Hypothalamicpituitary-adrenal axis in Asthmatic Subjects. Chest 128:70-77.
538.
Kino T, Ichijo T, Tiulpakov A Chheng L, Kozasa T and. Chrousos GP (2005) The GTP-binding (G) Protein 
Interacts with the Activated Glucocorticoid Receptor and Suppresses Its Transcriptional Activity in the Nucleus. J
Cell Biol 20;169(6):885-96.
(2005)
44
George P. Chrousos, M.D.
539.
Kakourou T, Kanaka-Gantenbein C, Papadopoulou A, Kaloumenou E, Chrousos GP (2005) Increased prevalence of
chronic autoimmune (Hashimoto's) thyroiditis in children and adolescents with vitiligo. J Am Acad Dermatol. 2005
Aug; 53(2):220-3.
540.
Kino T, Kozasa T and Chrousos GP (2005) Statin-induced Blockade of Prenylation Alters Nucleocytoplasmic
Shuttling of GTP-binding Proteins 2 and 2 and Enhances their Suppressive Effect on Glucocorticoid Receptor
Transcriptional Activity. Eur J Clin Invest 35:508-513.
541.
Schulpis KH, Papassotiriou I, Tsakiris S, Vounatsou M, and Chrousos GP (2005) Increased Plasma Adiponectin
Concentrations in Poorly Controlled Patients with Phenyketonuria (PKU) Normalize with a Strict Diet: Evidence for
Catecholamine-mediated Adiponectin Regulation and a Complex Effect of PKU Diet on Atherogenesis Risk
Factors. Metabolism 54:1350-1355.
542.
Siahanidou T, Mandyla H, Vounatsou M, Anagnostakis D, Papassotiriou I, and Chrousos GP (2005) Circulating
Peptide YY Concentrations Are Higher in Preterm than Term Infants and Correlate Negatively with Body Weight
and Positively with Serum Ghrelin Levels. Clin Chemistry. 51(11):2131-7.
543.
Papoutsi Z, Kassi E, Tsiapara A, Fokialakis N, Chrousos GP, Moutsatsou P. (2005) Evaluation of
Estrogenic/Antiestrogenic Activity of Ellagic Acid via the Estrogen Receptor Subtypes ERalpha and ERbeta. J
Agric Food Chem. 53(20):7715-7720.
544.
Papoutsi Z, Kassi E, Mitakou S, Aligiannis N, Chrousos GP, Moutsatsou P. (2006) Acteoside and Martynoside
Exhibit Estrogenic/Antiestrogenic Activity. J Steroid Biochem and Mol Biol 98(1):63-71. Epub 2005 Sep 28.
545.
Ichijo T, Voutetakis A, Cotrim AP, Bhattachryya N, Fujii M, Chrousos GP and Kino T (2005) The SMAD6/histone
Deacetylase 3 Complex Silences the Transcriptional Activity of the Glucocorticoid Receptor: Potential Clinical
Implications. J Biol Chem. 280(51):42067-77.
546.
Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras S, Yannakoulia M, Chrousos G, Sidossis L.
(2005) Aerobic Exercise Training Improves Insulin Sensitivity without Changes in Body Weight, Body Fat,
Adiponectin and Inflammatory Markers in Overweight and Obese Girls. Metabolism 54(11): 1472-1479.
547.
Papandreou O, Soldatou A, Tsitsika A, Cariyannis C, Papandreou T, Papassotiriou, Zachariadi A, and Chrousos GP
(2005) Serum S100b Protein in Children with Acute Recurrent Headache: A Potentially Useful Marker for
Migraine. Headache 45: 1313-1316.
548.
Kino T, Liou S-H, Charmandari E and Chrousos GP (2005) Pathologic Human Glucocorticoid Receptor Mutants
Demonstrate Defective Motility inside the Nucleus of Living Cells: Percent Recovery Time afterPhotobleaching
(FRAP) is an Integrated Measure of Receptor Function. Mol Med. 10(7-12): 80-8.
549.
Bamberger AM, Minas V, Kalantaridou S, Radde J, Sadeghian H, Loening T, Charalambopoulos J, Bruemmer J,
Wagener C, Bamberger CM, Schulte HM, Chrousos GP and Makrigiannakis A (2005) Corticotropin-releasing
Hormone Modulates Human Trophoblast Invasion through CEACAM-1 Regulation. Am J Pathol. 2006 68(1): 14150.
550.
Meduri GU, Muthiah MP, Carratu P, Eltorky M and Chrousos GP (2005) Nuclear factor-B- and Glucocorticoid
Receptor a- mediated Mechanisms in Regulation of Systemic and Pulmonary Inflammation during Sepsis and Acute
Respiratory Distress Syndrome: Evidence for Inflammation–induced Target Tissue Resistance to Glucocorticoids.
Neuroimmunomodulation 12(6): 321-38.
551.
Nicolaidou P, Papadopoulou A, Georgouli H, Matsinos YG, Tsapra H, Fretzayas A, Giannoulia-Karantana A,
Kitsiou S, Douros K, Papassotiriou I, Chrousos GP. (2006) Calcium and Vitamin D Metabolism in Hypocalcemic
Vitamin D-Resistant Rickets Carriers. Horm Res. 65(2): 83-88.
552.
Charmandari E, Kino T, Ichijo T, Zachman K, Alatsatianos A, Chrousos GP (2006) Functional Characterization of
the Natural Human Glucocorticoid Receptor (GR) Mutants hGRalphaR477H and hGRalphaG679S Associated with
Generalized Glucocorticoid Resistance. J Clin Endocrinol 91: 1535-1543.
45
George P. Chrousos, M.D.
553.
Ronsaville DS, Municchi G, Laney C, Cizza G, Meyer SE, Haim A, Radke-Yarrow M, Chrousos, GP, Gold PW,
Martinez PE. (2006) Maternal and Environmental Factors Influence the Hypothalamic-pituitary-adrenal axis
Response to Corticotropin-releasing Hormone Infusion in Offspring of Mothers with or without Mood Disorders.
Develop Psychopathol 18(1): 173-94.
554.
Alesci S, Manoli I, Su Y, Blackman M, Rennert O, Chrousos GP (2006) Development of a New Mitochondriafocused cDNA Microarray (hMitChip): Validation in Skeletal Muscle Cells and Implications for Pharmaco-and
Mitogenomics. The Pharmacogenomics J. 6(5):333-42.
555.
Kino T, Souvatzoglou E, Charmandari E, Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H,
Chrousos GP and Segars JH (2006) Rho Family Guanine Nucleotide Exchange Factor Brx Couples Extracellular
Signals to the Glucocorticoid Signaling System. J Biol Chem. 281: 9118-9126.
556.
Krisnamoorthy S, Bei T, Zoumakis E, Chrousos GP and Iliadis AA (2006) Morphological and Binding Properties of
Interleukin-6 on Thin ZnO Films Grown on (100) Silicon Substrates for Biosensor Applications. Biosens
Bioelectron 22: 707-14.
557.
Giedd JN, Clasen LS, Lenroot R, Greenstein D, Wallace GL, Ordaz S, Molloy EA, Blumenthal JD, Tossell JW,
Stayer C, Samango-Sprouse CA, Shen D, Davatzikos C, Merke D, Chrousos GP (2006). Puberty-related influences
on brain development. Mol Cell Endocrinol. 254-255:154-62.
558.
Vgontzas AN, Trakada G, Bixler EO, Lin H-M, Pejovic S, Zoumakis E, Chrousos, GP, Legro R (2006) Plasma IL-6
and TNF-alpha Levels are Elevated in Polycystic Ovary Syndrome Independently of Obesity and Sleep Apnea.
Metabolism 55: 1076-82.
559.
Priftis K, Papadimitriou A, Anthracopoulos B, Gatsopoulou E, Fretzayas A, Nicolaidou P, Chrousos G (2006)
Adrenal Function Improvement in Asthmatic Children on Inhaled Steroids Studied Longitudinally.
Neuroimmunomodulation 13(1): 56-62.
560.
Vgontzas AN, Pejovic, S, Zoumakis E, Lin H-M, Bixler EO, Basta M, Fang J, Sarrigiannidis A, Chrousos, GP
(2007) Daytime Napping After a Night of Sleep Loss Decreases Sleepiness, Improves Performance, and Causes
Beneficial Changes in Cortisol and Interleukin-6 Secretion. Am J Physiol Endocrinol Metab 292: E253-61.
561.
Fruchter O, Zoumakis E, Alesci S, De Martino M, Chrousos G, Hochberg Z. (2006) Intracrine modulation of gene
expression by intracellular generation of active glucocorticoids. Steroids. 71: 1001-6.
562.
Leong GM, Abad V, Charmandari E, Reynolds JC, Hill S, Chrousos GP and Nieman LK (2007). The effects of childand adolescent-onset endogenous Cushing syndrome on areal and volumetric bone mineral density, body
composition and growth: a 7-year prospective study into young adulthood. J Bone Miner Res 22(1):110-8.
563.
Siahanidou T, Mandyla H, Papassotiriou GP, Papasotiriou I, Chrousos GP (2007) Circulating Levels of Adiponectin
in Preterm Infants. Arch Dis Child Fet Neon 92(4):F286-90.
564.
Nicolaidou P, Papadopoulou A, Matsinos YG, Georgouli H, Fretzayas A, Papadimitriou A, Priftis K, Douros K,
Chrousos GP. (2006) Vitamin D Receptor Polymorphisms in Hypocalcemic Vitamin D-Resistant Rickets Carriers.
Horm Res. 67(4):179-183
565.
Spyridopoulos TN, Petridou ET, Skalkidou A, Dessypris N, Chrousos GP, Mantzoros CN, and the Obesity and
Cancer Oncology Group (2007) Low Adiponectin Levels are Associated with Renal Cell Carcinoma: A Casecontrol Study. Inter J Cancer 120: 1573-8.
566.
Arditi JD, Venihaki M, Karalis KP and Chrousos GP (2007) Anti-proliferative Effect of Adiponectin on MCF7
Breast Cancer Cells: A Potential Hormonal Link between Obesity and Cancer. Horm Metabol Res 39: 9-13.
567.
Alevizaki M, Cimponeriu A, Lekakis J, Papamichael C, Chrousos GP (2007) High Anticipatory Stress Plasma
Cortisol and Increased Sensitivity to Glucocorticoids Predict Severity of Coronary Artery Disease in Subjects
46
George P. Chrousos, M.D.
Undergoing Coronary Angiography. Metabolism 56: 222-6.
568.
Kakourou T, Karachristou K and Chrousos GP (2007) A Case Series of Alopecia Areata in Children: Impact of
Personal and Family History of Stress and Autoimmunity. JADV 21: 356-359.
569.
Bartzeliotou AI, Margeli AP, Tsironi M, Skenderi K, Bacoula C, Chrousos GP, Papassotiriou I. (2007) Circulating
levels of adhesion molecules and markers of endothelial activation in acute inflammation induced by prolonged
brisk exercise. Clin Biochem. 40(11):765-70.
570.
Krekoukia M, Nassis GP, Psarra G, Skenderi K, Chrousos GP, Sidossis LS. (2007) Elevated total and central
adiposity and low physical activity are associated with insulin resistance in children. Metabolism. 56(2):206-13
571.
Bai X, Wu J, Zhang Q, Alesci S, Manoli I, Blackman MR, Chrousos GP, Goldstein AL, Rennert OM, and Su YA.
(2007) The Third-Generation Human Mitochondria-focused cDNA Microarray (hMitChip3) and its Bioinformatics
Tool for Analysis of Gene Expression. BioTechniques 42:365-375
572.
Chrousos GP, O’Dowd L, Uryniak T, Simpson B, Casty M, Goldman M (2007) Basal and Cosyntropin-stimulated
Plasma Cortisol Concentrations, as Measured by High-performance Liquid Chromatography, in Children Aged 5
Months to <6 Years. J Clin Endocrinol Metab. 92(6):2125-9.
573.
Kino T, Rice KC and Chrousos GP (2007) The PPAR  Agonist GW501516 Suppresses Interleukin-6 Action via
STAT3 Inhibition. Eur J Clin Invest 37:425-433.
574.
Xekouki P, Nikolakopoulou NM, Papageorgiou A, Livadas S, Voutetakis A, Magiakou MA, Chrousos GP, Spiliotis
BE, Dacou-Voutetakis C. (2007) Glucose Dysregulation in Obese Children: Predictive, Risk, and Potential
Protective Factors. Obesity (Silver Spring) 15: 860-869.
575.
Kino T, Ichijo T, Amin ND, Kesavapany S, Amin ND, Wang Y, Kim N, Player A, Garabedian MJ, Kawasaki E,
Pant HC and Chrousos GP (2007) Cyclin-dependent Kinase 5 Differentially Regulates the Transcriptional Activity
of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to
Glucocorticoids and Stress. Mol Endocrinol. 21(7):1552-68
576.
Papaevangelou V, Papassotiriou I, Vounatsou M, Chrousos G, Theodoridou M. (2007) Changes in leptin serum
levels in HIV-infected children receiving highly active antiretroviral therapy. Scand J Clin Lab Invest. 67:291-6.
577.
Nicolaidou P, Tsitsika A, Papadimitriou A, Karantana A, Papadopoulou A, Psychou F, Liakopoulou D, Georgouli
H, Kakourou T, Chrousos G. (2007) Hereditary vitamin D-resistant rickets in Greek children: genotype, phenotype,
and long-term response to treatment. J Pediatr Endocrinol Metab. 20:425-30.
578.
Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC and Chrousos GP (2007) 3-O-formyl-20R,21Epoxyresibufogenin Suppresses Interleukin 6-type Cytokine Actions by Targeting the gp130 Subunit : Potential
Clinical Implications. J All Clin Immunol 120:437-444.
579.
Trimis G, Moschovi M, Papassotiriou I, Chrousos G, Tzortzatou-Stathopoulou (2007) Early Indicators of
Dysmetabolic Syndrome in Young Survivors of Acute Lymphoblastic Leukemia in Childhood as a Target for
Preventing Disease. J Pediatr Hematol Oncol. 29:309-314.
580.
Mantzoros CS, Trakatelli M, Gogas H, Dessypris N, Stratigos A, Chrousos GP, Petridou ET. (2007) Circulating
adiponectin levels in relation to melanoma: A case-control study. Eur J Cancer 43:1430-6
581.
Mills JL, Hediger ML, Molloy CA, Chrousos GP, Manning-Courtney P, Yu KF, Brasington M, England LJ (2007)
Elevated Levels of Growth-Related Hormones in Autism and Autism Spectrum Disorder. Clin Endocrinol. 67:230237
582.
Siahanidou T, Mandyla H, Militsi H, Papassotiriou I, Chrousos G. (2007) Peptide YY (3-36) Represents a High
Percentage of Total PYY Immunoreactivity in Preterm and Full-Term Infants and Correlates Independently With
Markers of Adiposity and Serum Ghrelin Concentrations. Pediatr Res 62(2):200-3
47
George P. Chrousos, M.D.
583.
Livadas S, Magiakou MA, Mengreli C, Girginoudis P, Galani C, Smyrnaki P, Kanaka-Gantenbein C, Xekouki P,
Chrousos GP, Dacou-Voutetakis C. (2007) Obesity and Attenuated Adiposity Rebound in Children with Congenital
Hypothyroidism. Normalization of BMI Values in Adolescents. Horm Metab Res. 39:524-528
584.
Pervanidou P, Kolaitis G, Charitaki S, Lazaropoulou Ch, Papassotiriou I, Hindmarsh P, Bakoula Ch, Tsiantis J and
Chrousos GP (2007) The Natural History of Neuroendocrine Changes in Pediatric Post-traumatic Stress Disorder
(PTSD) after Motor Vehicle Accidents: Progressive Divergence of Noradrenaline and Cortisol Concentrations over
Time. Biol Psychiatry 62(10):1095-102
585.
Charmandari E, Kino T, Ichijo T, Jubiz W, Zachman K, Chrousos GP (2007) A Novel Point Mutation in Helix 11 of
the Ligand-binding Domain (LBD) of the Human Glucocorticoid Receptor (GR) Gene Causing Generalized
Glucocorticoid Resistance. J Clin Endocrinol Metab. 92:3986-3990
586.
Minas V, Rolaki A, Kalantaridou SN, Sidiropoulos J, Mitrou S, Petsas G, Jeschke U, Paraskevaidis EA, Fountzilas G,
Chrousos GP, Pavlidis N and Makrigiannakis A (2007) Intratumoral CRH Modulates Immuno-escape of Ovarian
Cancer Cells through FasL Regulation. Br J Cancer 97(5):637-45
587.
Vgontzas AN, S Pejovic S, Zoumakis E, Lin H-M, Bechtel C, EO Bixler EO, A. Sarrigiannidis A, Basta M,
Chrousos GP (2007) Hypothalamic-Pituitary-AdrenalAxis Activity in Obese Men with and without Sleep Apnea:
Effects of Continuous Positive Airway Pressure Therapy. J Clin Endocrinol Metab 92: 4199-4207
588.
Pervanidou P, Kolaitis G, Charitaki S, Margeli A, Ferentinos S, Bakoula C, Lazaropoulou C, Papassotiriou I, Tsiantis
J and Chrousos GP (2007) Elevated Morning Serum Interleukin (IL)-6 or Evening Salivary Cortisol Concentrations
Predict Posttraumatic Stress Disorder in Children and Adolescents Six Months after a Motor Vehicle Accident.
Psychoneuroendocrinology 32(8-10):991-9
589.
Pavlatou MG, Mastorakos G, Lekakis I, Liatis, Vamvakou G, Zoumakis E, Papassotiriou I, Rabavilas AD,
Katsilambros N and Chrousos GP (2008) Chronic Administration of an Angiotensin II Receptor Antagonist Resets
the Hypothalamic-pituitary-adrenal Axis and Improves the Affect of Patients with Diabetes Mellitus Type 2:
Preliminary Results. Stress 11:62-72
590.
Hoffman KE, Derdak J, Bernstein D M, Reynolds JC, Avila NA, Gerber L, Steinberg S, Chrousos G, Mackall CL
and Mansky PJ (2008) Metabolic Syndrome Traits in Long-term Survivors of Pediatric Sarcoma at a Single
Institution. Ped Blood and Cancer 50(2):341-6
591.
Shrivastav S, Kino K, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP and Kopp JB (2007) HIV-1
Vpr suppresses transcriptional activity of PPAR and inhibits adipocyte differentiation: Implications for HIVassociated lipodystrophy. Mol Endo 22:234-247
592.
Gogas H, Trakatelli M, Dessypris N, Terzidis A, Katsambas A, Chrousos GP, Petridou ET (2007) Melanoma risk in
association with serum leptin levels and lifestyle parameters: a case–control study. Ann Oncol 19:384389
593.
Ichijo T, Chrousos GP and KinoT (2007) Activated Glucocorticoid Receptor Interacts with the INHAT Component
Set/TAF-I and Releases it from a Glucocorticoid-responsive Gene Promoter, Relieving Repression: Implications
for the Pathogenesis of Glucocorticoid Resistance in Acute Undifferentiated Leukemia with Set-Can Translocation.
Mol Cell Endocrinol 283:19-31
594.
Karamessinis PM, Malamitsi-Puchner A, Boutsikou T, Makridakis M, Vougas K, Fountoulakis M, Vlahou A,
Chrousos G. (2007) Marked defects in the expression and glycosylation of alpha -2-HS glycoprotein/fetuin-A in
plasma from neonates with intrauterine growth restriction: Proteomic screening and potential clinical implications.
Mol Cell Proteomics 7:591-599
595.
Pervanidou P, Margeli A, Lazaropoulou C, Papassotiriou I and Chrousos GP (2008) The Immediate and Long-term
Impact of Physical or Emotional Stress from Motor Vehicle Accidents on Circulating Stress Hormones and Adipocytokines in Children and Adolescents. Stress 11:438-447
48
George P. Chrousos, M.D.
596.
Vgontzas AN, Lin H-M, Papaliagka M, Calhoun S, Vela-Bueno A, Chrousos GP, O. Bixler EO (2008) Short Sleep
Duration and Obesity: The Role of Emotional Stress and Sleep Disturbances Int J Obes (Lond). 2008
May;32(5):801-809
597.
Skenderi KP, Tsironi M, Lazaropoulou C, Anastasiou CA, Matalas AL, Kanavaki I, Thalmann M, Goussetis E,
Papassotiriou I, Chrousos GP (2008) Changes in free radical generation and antioxidant capacity during
ultramarathon foot race. Eur J Clin Invest. Mar 38 (3):159-165.
598.
Krishnamoorthy S, Iliadis A A, Bei T and Chrousos G (2008) ZnO SAW Biosensor for Interleukin-6 Detection.
Biosensors and Bioelectronics 24(2): 313-8.
599.
Kanaka-Gantenbein C, Margeli A, Pervanidou P, Sakka S, Mastorakos G, Chrousos GP, Papassotiriou I (2008)
Retinol Binding Protein-4 and Lipocalin-2 in Childhood and Adolescent Obesity: When Children are not just Small
Adults. Clin. Chem. 54: 1176-1182
600.
Moschovi M, Trimis G, Vounatsou M, Katsibardi K, Margeli A, Dimitriadi F, Papassotiriou I, Chrousos GP,
Tzortzatou-Stathopoulou F (2008) Serial Plasma Concentrations of PYY and Ghrelin during Chemotherapy in
Children with Acute Lymphoblastic Leukemia. J Ped Hem Oncol 30: 733-737
601.
Vgontzas AN, Zoumakis E, Bixler EO, Lin H-M, Collins B, Basta M, Pejovic S, Chrousos GP (2008) Selective
Effects of CPAP on Sleep Apnea-related Manifestations. Eu J. Clin Invest 38(8): 585-95.
602.
Elenkov1J, Kvetnansky R, Hashiramoto A, Bakalov VK, Link AA, Zachman K, Crane M, Jezova D, Rovensky J,
Dimitrov MA, Gold PW, Bonini S, Fleisher T, Chrousos GP , Wilder RL (2008) Low versus High Baseline
Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-like NeurohormonalImmune Phenotypes in Humans. J Immunol 181:1737-1745
603.
Kaloumenou I, Mastorakos G, Alevizaki M, Duntas LH, Mantzou E, Ladopoulos C, Antoniou A, Chiotis D,
Papassotiriou I, Chrousos GP, Dacou-Voutetakis C (2008) Thyroid autoimmunity in schoolchildren in an area with
long-standing iodine sufficiency: correlation with gender, pubertal stage, and maternal thyroid autoimmunity.
Thyroid 18(7):747-54
604.
Charmandari E, Ichijo T, Jubiz W, Baid S, Zachman K, Chrousos GP, Kino T. (2008) A Novel Point Mutation in the
Amino Terminal Domain of the Human Glucocorticoid Receptor (hGR) Gene Enhancing hGR-mediated Gene
Expression. J Clin Endocrinol Metab. 93: 4963-4968
605.
Nader N, Chrousos GP and Kino T (2009) Circadian Rhythm Transcription Factor CLOCK Regulates the
Transcriptional Activity of the Glucocorticoid Receptor by Acetylating its Hinge Region Lysine Cluster: Potential
Physiologic Implications. FASEB J. 23:1572-83
606.
Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, and
Segars JH (2009) Guanine Nucleotide Exchange Factor Brx Mediates Lymphocyte Adaptive Response to Osmotic
Stress: An Intracellular Signaling Pathway Linking Extracellular Hyperosmosis and Immune Activation. Sci Signal
2(57): ra5
607.
Fishbein D, Sheppard M, Hyde C, Hubal R, Newlin D, Serin R, Chrousos G, Alesci S (2009) Deficits in Behavioral
Inhibition Predict Treatment Engagement in Prison Inmates. Law Hum Behav 33:419-435
608.
Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, Kanaka-Gantenbein C (2009) Euthyroid
Hyperthyrotropinemia in Children Born after In Vitro Fertilisation. J Clin Endocrinol Metab 94: 1338-1341
609.
Bakoula C, Kolaitis G, Veltsista A, Gika A, Chrousos GP. (2009) Parental stress affects the emotions and behaviour
of children up to adolescence: A Greek prospective, longitudinal study. Stress. Feb 10:1. [Epub ahead of print]
49
George P. Chrousos, M.D.
610.
Piaditis GP, Kaltsas GA, Androulakis II, Gouli A, Makras P, Papadogias D, Dimitriou K, Ragkou D, Markou A,
Vamvakidis K, Zografos G, Chrousos G. (2009) High prevalence of autonomous cortisol and aldosterone secretion
from adrenal adenomas. Clin Endocrinol (Oxf) 71:772-778
611.
Kino T, Manoli I, Kelkar S, Wang Y3, Su YA and Chrousos GP (2009) Human Glucocorticoid Receptor (GR)
Isoform  Has Intrinsic, GR-independent Transcriptional Activity. BBRC 381: 671-675
612.
Loizou S, Paraschos S, Mitakou S, Chrousos G, Lekakis I, Moutsatsou P (2009) Chios Mastic Gum Extract and
Isolated Phytosterol Tirucallol Exhibit Anti-inflammatory Activity in Human Aortic Endothelial Cells. Exp Biol
Med (Maywood) 234:553-561
613.
Livadas S, Dracopoulou M, Vasileiadi K, Lazaropoulou C Magiakou MA, P Xekouki P, Voutetakis A,
Kanaka-Gantenbein C, Papassotiriou I, Stefanadis C, Chrousos GP, Dacou-Voutetakis C (2009) Elevated
coagulation and inflammatory markers in adolescents with a history of premature adrenarche. Metabolism
58: 576–581
614.
Spyridopoulos TN, Petridou ET, Dessypris N, Terzidis A, Skalkidou A, Deliveliotis C, Chrousos GP;
Obesity and Cancer Oncology Group. (2009) Inverse association of leptin levels with renal cell
carcinoma: results from a case-control study. Hormones (Athens) 8: 39-46
615.
Bixler EO, Papaliaga MN, Vgontzas AN, Lin HM, Pejovic S, Karataraki M, Vela-Bueno A, Chrousos
GP. (2009) Women sleep objectively better than men and the sleep of young women is more resilient to
external stressors: effects of age and menopause. J Sleep Res 18:221-228
616.
Vgontzas AN, Liao D; Bixler EO, Chrousos GP, Vela-Bueno A (2009) Insomnia with Objective Short
Sleep Duration is Associated with a High Risk for Hypertension. Sleep 32:491-497
617.
Pervanidou P, Margeli A, Akalestos A, Sakka S, Kanaka-Gantenbein C, Papassotiriou I and GP Chrousos
(2009) Associations between Circulating N-type Brain Natriuretic Peptide (NT-proBNP) and Adiponectin
Concentrations Depend on Obesity Level in Female Adolescents: Gender Dimorphic Findings. Horm
Metab Res 41:829-833
618.
Livadas S, Dracopoulou M, Lazaropoulou C, Papassotiriou I, Sertedaki A, Angelopoulos N, Chrousos GP
and Dacou-Voutetakis A (2009) A Favorable Metabolic and Antiatherogenic Profile in Carriers of
CYP21A2 Gene Mutations Supports the Theory of a Survival Advantage in this Population. Horm Res 72:
337-343.
619.
Moschovi M, Trimis G, Vounatsou M, Katsibardi K, Margeli A, Damianos A, Chrousos G, and
Papassotiriou I (2010) Serial Plasma Concentrations of Adiponectin, Leptin, and Resistin During Therapy
in Children with Acute Lymphoblastic Leukemia. J Ped Hematol Oncol 2010 Jan; 32(1):e8-13
620.
Tsaoussoglou M, Bixler EO, Calhoun S, Chrousos GP, Sauder K., Vgontzas AN (2009) Sleep Disordered
Breathing in Obese Children is Associated with Prevalent EDS, Inflammation and Metabolic
Abnormalities. J Clin Endocrinol Metab 95:143-150
621.
Lang L, Y. Ma Y, Kim BM, Jagoda EM, Rice KC, Szajek LP, Contoreggi C, Gold PW, Chrousos GP,
Eckelman WC, and Kiesewetter DO (2009) [76Br]BMK-I-152, a non-peptide analogue for PET imaging
of corticotropin-releasing hormone type 1 receptor (CRHR1). J Lab Compounds & Radiopharm
622.
Magiakou MA, Manousaki D, Papadaki M, Hadjidakis D, Levidou G, Vakaki M, Papaefstathiou A,
Lalioti N, Kanaka-Gantenbein C, Piaditis G, Chrousos GP, Dacou-Voutetakis C. (2009)The Efficacy and
50
George P. Chrousos, M.D.
Safety of Gonadotropin-Releasing Hormone Analog Treatment in Childhood and Adolescence: A Single
Center, Long-Term Follow-Up Study. J Clin Endocrinol Metab. 95:109-117
623.
Kaditis AG, Lianou L, Hatzinikolaou S, Kalampouka E, Gartagani-Panayiotopoulou P, Zintzaras E,
Chrousos G. (2009) Tonsillar size in 2- to 14-year-old children with and without snoring. Pediatr
Pulmonol. 44:1216-1222
624.
Loizou S, Lekakis I, Chrousos GP, Moutsatsou P (2009) beta-Sitosterol exhibits anti-inflammatory
activity in human aortic endothelial cells. Mol Nutr Food Res. 2009 Nov 24 [Epub ahead of print]
625.
Samara A, Vougas K, Papadopoulou A, Anastasiadou E, Baloyanni N, Paronis E, Chrousos GP, Tsangaris
GT. (2009) Proteomics reveal rat hippocampal lateral asymmetry. Hippocampus. 2009 Dec 17 [Epub
ahead of print]
626.
Sakka SD, Loutradis D, Kanaka-Gantenbein C, Margeli A, Papastamataki M, Papassotiriou I, Chrousos GP (2010)
Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in
children born after in vitro fertilization. Fertil Steril. 94(5):1693-9
627.
Kino T, Hurt DE, Ichijo T, Nader N and Chrousos GP (2010) Noncoding RNA Gas5 is a Growth Arrest and
Starvation-associated Repressor for the Glucocorticoid Receptor. Science Signaling Feb 2;3 (107):ra8.
628.
Siahanidou T, Margeli A, Davradou M, Apostolakou F, Papassotiriou I, Roma E, Mandyla H, Chrousos G. (2010)
Circulating adipocyte fatty acid binding protein levels in healthy preterm infants: Positive correlation with weight
gain and total-cholesterol levels. Early Hum Dev. 2010 Mar 13. [Epub ahead of print]
629.
Kino T, Jaffe H, Amin ND, Chakrabarti M, Zheng YL, Chrousos GP, and Pant HC (2010) Cyclin-Dependent Kinase
5 Modulates the Transcriptional Activity of the Mineralocorticoid Receptor (MR) and Regulates Expression of
Brain-Derived Neurotrophic Factor. Mol Endocrinol 24(5):941-52
630.
Gazouli M, Pachoula I, Panayotou I, Mantzaris G, Chrousos G, Anagnou NP, Roma-Giannikou E (2010)
NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J
Gastroenterol. 6(14): 1753-8
631.
Moschovi M, Trimis G, Tsotra M, Chatzi F, Karamolegou K, Santou A, Tourkantoni N, Chrousos G. (2010)
Efficacy and safety of linezolid in immunocompromised children with cancer. Pediatr Int. 2010 Feb 9. [Epub ahead
of print]
632.
Pervanidou P, Akalestos A, Sakka S, Kanaka-Gantenbein C, Papassotiriou I, Chrousos GP (2010) Gender dimorphic
associations between N-terminal pro-brain natriuretic peptide, body mass index and blood pressure in children and
adolescents. Horm Res Paediatr. 73(5): 341-8
633.
Syrengelas D, Siahanidou T, Kourlaba G, Kleisiouni P, Bakoula C, Chrousos GP (2010) Standardization of the
Alberta infant motor scale in full-term Greek infants: Preliminary results. Early Hum Dev. May 7. [Epub ahead of
print]
634.
Pejovic S, Vgontzas AN, Basta M, Tsaoussoglou M, Zoumakis E, Vgontzas A, Bixler EO, Chrousos GP. (2010)
Leptin and hunger levels in young healthy adults after one night of sleep loss. J Sleep Res, 2010 Jun 9. [Epub ahead
of print]
635.
Nader N, Ng SS, Lambrou GI, Pervanidou P, Wang Y, Chrousos GP, Kino T. (2010)
Adenosine 5'-Monophosphate-Activated Protein Kinase Regulates Metabolic Actions of Glucocorticoids by
Phosphorylating the Glucocorticoid Receptor through p38 Mitogen-Activated Protein Kinase.Mol Endocrinol. 24:
1748–1764
51
George P. Chrousos, M.D.
636.
Al-Attas OS, Al-Daghri NM, Alokail M, Alfadda A, Bamkahramah A, Sabico S, Pritlove D, Harte A, Tripathi G,
McTernan P, Kumar S, Chrousos G. (2010) Adiposity and Insulin Resistance Correlate with Telomere Length in
Middle-aged Arabs: The Influence of Circulating Adiponectin. Eur J Endocrinol. 2010 Aug 2. [Epub ahead of print]
637.
Bathrellou E, Yannakoulia M, Papanikolaou K, Pehlivanidis A, Pervanidou P, Kanaka-Gantenbein C, Tokou I,
Tsiantis J, Chrousos GP, Sidossis LS. (2010) Parental involvement does not augment the effectiveness of an intense
behavioral program for the treatment of childhood obesity. Hormones (Athens). 2010 Apr-Jun;9(2):171-5.PMID:
20687401 [PubMed - in process]
2.
638.
Naka KK, Kalantaridou SN, Kravariti M, Bechlioulis A, Kazakos N, Calis KA, Makrigiannakis A, Katsouras CS,
Chrousos GP, Tsatsoulis A, Michalis LK. (2010) Effect of the insulin sensitizers metformin and pioglitazone on
endothelial function in young women with polycystic ovary syndrome: a prospective randomized study. Fertil Steril.
2010 Aug 3. [Epub ahead of print]
639.
Al-Daghri NM, Al-Attas OS, Al-Okail MS, Alkharfy KM, Al-Yousef MA, Nadhrah HM, Sabico SB, Chrousos GP.
(2010) Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults.
Saudi Med J. 2010 Jul;31 (7):775-80.
640.
Al-Disi D, Al-Daghri N, Khanam L, Al-Othman A, Al-Saif M, Sabico S and Chrousos G (2010) Subjective sleep
duration and quality influence diet composition and circulating adipocytokines and ghrelin levels in teen-age girls.
Endo J [Epub ahead of print]
641.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Sabico SL, Chrousos GP (2010) Decreasing Prevalence
of the Full Metabolic Syndrome but a Persistently High Prevalence of Dyslipidemia among Adult Arabs. PLoS One.
2010 Aug 13;5 (8). pii: e12159.
642.
Chouliaras G, Panayiotou J, Dimakou C, Pachoula J, Orfanou I, Chrousos GP, Roma-Giannikou E (2010) Biological
Agents in Paediatric Inflammatory Bowel Disease: A Clinical Observation Study from Greece. Acta Gatroenterol.
Belg 73: 342-348.
643.
Douzinas EE, Betrosian A, Giamarellos-Bourboulis EJ, Tasoulis MK, Prigouris P, Livaditi O, Andrianakis I,
Goutas N, Vlachodimitropoulos D, Pelekanou A, Villiotou V, Legakis I, Chrousos GP (2010) Hypoxemic
resuscitation from hemorrhagic shock prevents lung injury and attenuates oxidative response and IL-8 overexpression. Free Radic Biol Med. 2010 Nov 6. [Epub ahead of print]
644.
Chouliaras G, Panayiotou J, Dimakou C, Pachoula J, Orfanou I, Chrousos GP, Roma-Giannikou E. (2010)
Biological agents in paediatric inflammatory bowel disease: a clinical observation study from Greece. Acta
Gastroenterol Belg. Jul-Sep; 73(3): 342-8.
645.
Markopoulos MC, Rizos D, Valsamakis G, Deligeoroglou E, Grigoriou O, Chrousos GP, Creatsas G, Mastorakos G.
Hyperandrogenism in Women with Polycystic Ovary Syndrome Persists after Menopause.
J Clin Endocrinol Metab. 2010 Dec 22. [Epub ahead of print]
646.
Pavlatou MG, Mastorakos G, Margeli A, Kouskouni E, Tentolouris N, Katsilambros N, Chrousos GP, Papassotiriou
I. Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation. Eur J
Clin Invest. 2010 Dec 22 [Epub ahead of print]
647.
Moutsatsou P, Papoutsi Z, Kassi N, Heldring N , Zhao G, Tsiapara A, Melliou E, Chrousos GP, Chinou I,
Karshikoff A, Nilsson L, Dahlman-Wright K (2010) Fatty Acids Derived from Royal Jelly Are Modulators of
Estrogen Receptor Functions. PLoS ONE 5(12): e15594
648.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Nadhrah HM, Al-Othman A, Al-Saleh Y,
Sabico S, Chrousos GP. (2010) Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Cent
Eur J Med 5(6): 752-757
52
George P. Chrousos, M.D.
649.
Jacobsson JA, Rask-Andersen M, Risérus U, Moschonis G, Koumpitski A, Chrousos GP, Lannfelt L, Marcus C,
Gyllensten U, Schiöth HB, Fredriksson R. Genetic variants near the MGAT1 gene are associated with body weight,
BMI and fatty acid metabolism among adults and children. Int J Obes (Lond). 2011 Feb 8. [Epub ahead of print]
650.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yakout SM, Sabico SB, Gibson GC, Chrousos GP, Kumar
S (2011) Parent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic Traits.
PLoS ONE 6(4): e18182. doi:10.1371/journal.pone.0018182
651.
Vasilopoulos Y, Sarafidou T, Bagiatis V, Skriapa L, Goutzelas Y, Pervanidou P, Lazopoulou N, Chrousos GP,
Mamuris Z. (2011) Association Between Polymorphisms in MTHFR and APOA5 and Metabolic Syndrome in the
Greek Population. Genet Test Mol Biomarkers. 2011 Apr 7. [Epub ahead of print]
652.
Gouli A, Kaltsas G, Tzonou A, Markou A, Androulakis II, Ragkou D, Vamvakidis K, Zografos G, Kontogeorgos G,
Chrousos GP, Piaditis G. High Prevalence of Autonomous Aldosterone Secretion among Patients with Essential
Hypertension. (2011) Eur J Clin Invest. 2011 May 3. doi: 10.1111/j.1365-2362.2011.02531.x. [Epub ahead of print]
653.
Galata Z, Moschonis G, Makridakis M, Dimitraki P, Nicolaides NC, Manios Y, Bartzeliotou A, Chrousos GP and
Charmandari E (2011) Plasma proteomic analysis in obese and overweight prepubertal children. Eur J Clin Invest
[Epub ahead of print]
654.
Leka S, Kousta E, Anyfandakis K, Dolianiti M, Vakaki M, Linos D, Chrousos GP, Papathanasiou A (2011) Primary
pigmented nodular adrenocortical disease: a case report in a 7-year-old girl. J Pediatr Endocrinol Metab. 24(3-4):
197-202.
655.
Al-Daghri NM, Al-Attas OS , Majed S. Alokail MS, Alkharfy KM, Yousef M , Sabico SL, Chrousos GP (2011)
Diabetes Mellitus Type 2 and other Chronic Non-communicable Diseases in the Central Region, Saudi Arabia
(Riyadh Cohort 2): A Decade of an Epidemic. BMC Medicine 9:76
656.
Malakasioti G, Gourgoulianis K, Chrousos G, and Kaditis A (2011) Interactions of Obstructive Sleep-disordered
Breathing with Recurrent Wheezing or Asthma and their Effects on Sleep Quality. Ped Pulmonology [Epub ahead of
print]
657.
Spoulou V, Kanaka-Gantenbein C, Bathrellou I, Mora S, Mostrou G, Sidossis L, Chrousos G, Theodoridou M.
(2011) Monitoring of Lipodystrophic and Metabolic Abnormalities in HIV-1 Infected Children on Antiretroviral
Therapy. Hormones (Athens) Apr;10 (2):149-55.
657.
Michos A, Tzanoudaki M, Villa A, Giliani S, Chrousos G, Kanariou M. (2011) Severe Combined Immunodeficiency
in Greek Children over a 20-Year Period: Rarity of γ(c)-Chain Deficiency (X-Linked) Type. J Clin Immunol. 2011
Jul 6. [Epub ahead of print]
658.
Kolaitis G, Giannakopoulos G, Liakopoulou M, Pervanidou P, Charitaki S, Mihas C, Ferentinos S, Papassotiriou I,
Chrousos GP, Tsiantis J. (2011) Predicting pediatric posttraumatic stress disorder after road traffic accidents: The
role of parental psychopathology. J Trauma Stress. 2011 Aug 2. doi: 10.1002/jts.20667. [Epub ahead of print]
659.
Karamouzis I, Pervanidou P, Berardelli R, Iliadis S, Papassotiriou I , Karamouzis M, Chrousos GP , KanakaGantenbein C (2011) Enhanced Oxidative Stress and Platelet Activation Combined with Reduced Antioxidant
Capacity in Obese Prepubertal and Adolescent Girls with Full or Partial Metabolic Syndrome Horm Metab Res 43:
607–613
660.
Andreou, E.; Alexopoulos, E.C.; Lionis, C.; Varvogli, L.; Gnardellis, C.; Chrousos, G.P.; Darviri, C. (2011)
Perceived Stress Scale: Reliability and Validity Study in Greece. Int. J. Environ. Res. Public Health 8, 3287-3298.
661.
Pogka V, Kossivakis A, Kalliaropoulos A, Moutousi A, Sgouras D, Panagiotopoulos T, Chrousos GP, Theodoridou
M, Syriopoulou VP, Mentis AF. (2011) Respiratory viruses involved in influenza-like illness in a Greek pediatric
population during the winter period of the years 2005-2008. J Med Virol. 2011 Oct; 83(10): 1841-8.
53
George P. Chrousos, M.D.
662.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, El-Kholie E, Yousef M, Al-Othman A, Al-Saleh Y,
Sabico S, Kumar S, Chrousos GP. (2011) Increased Vitamin D Supplementation Recommended during Summer
Season in the Gulf Region: A Counterintuitive Seasonal Effect in Vitamin D Levels in Adult, Overweight and Obese
Middle-eastern Residents. Clin Endocrinol (Oxf). 2011 Sep 12. doi: 10.1111/j.1365-2265.2011.04219.x. [Epub
ahead of print]
663.
Rask-Andersen M, Jacobsson JA, Moschonis G, Chavan RA, Sikder MA, Allzén E, Alsiö J, Chrousos GP, Manios
Y, Fredriksson R, Schiöth HB. Association of TMEM18 variants with BMI and waist circumference in children and
correlation of mRNA expression in the PFC with body weight in rats. Eur J Hum Genet. 2011 Sep 28. doi:
10.1038/ejhg.2011.176. [Epub ahead of print]
664.
Charmandari E, Chrousos GP, Lambrou GI, Pavlaki A, Koide H, Ng SSM and Kino T (2011) Peripheral CLOCK
Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man. PLoS
ONE 6(9): e25612. doi: 10.1371/journal.pone.0025612
665.
Zannas AS, McQuoid DR, Steffens DC, Chrousos GP, Taylor WD. (2011) Stressful life events, perceived stress, and
12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158met
polymorphisms. Stress. 2011 Nov 1. [Epub ahead of print]
666.
Al-Daghri NM, Alkharfy KM, Al-Saleh Y, Al-Attas OS, Alokail MS, Al-Othman A, Moharram O, El-Kholie E,
Sabico S, Kumar S, Chrousos GP. (2011) Modest reversal of metabolic syndrome manifestations with vitamin D
status correction: a 12-month prospective study.Metabolism. 2011 Nov 8. [Epub ahead of print]
667.
Moschonis G, Chrousos GP, Lionis C, Mougios V, Manios Y. Association of total body and visceral fat mass with
iron deficiency in preadolescents: the Healthy Growth Study. Br J Nutr. 2011 Nov 16:1-10. [Epub ahead of print]
668.
Fragiadaki K, Tektonidou MG, Konsta M, Chrousos GP, Sfikakis PP. (2012) Sleep Disturbances and Interleukin 6
Receptor Inhibition in Rheumatoid Arthritis. J Rheumatol. 2011 Dec 1. [Epub ahead of print]
669.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Al-Othman A, Draz HM, Yakout SM, Al-Saleh Y, AlYousef M, Sabico S, Clerici M, Chrousos GP. (2011) Hypovitaminosis D Associations with Adverse Metabolic
Parameters Are Accentuated in Patients with Diabetes Mellitus Type 2: A BMI-Independent Role of Adiponectin? J
Endocrinol Invest. 2011 Dec 15. [Epub ahead of print]
670.
Tigani X, Artemiadis AK, Alexopoulos EC, Chrousos GP, Darviri C (2011) Gender differences in Greek
centenarians. A cross-sectional nationwide study, examining multiple socio-demographic and personality factors and
health locus of control. BMC Geriatr. 2011 Dec 21; 11 (1): 87 [Epub ahead of print]
671.
Vgontzas AN, Fernandez-Mendoza J, Bixler EO, Singareddy R, Shaffer ML, Calhoun SL, Liao D, Basta M,
Chrousos GP (2012) Persistent insomnia: the role of objective short sleep duration and mental health. Sleep. 2012
Jan 1; 35(1): 61-8.
672.
Almén MS, Jacobsson JA, Moschonis G, Benedict C, Chrousos GP, Fredriksson R, Schiöth HB. Genome wide
analysis reveals association of a FTO gene variant with epigenetic changes. Genomics. 2012 Jan 2. [Epub ahead of
print]
673.
Tsartsali L, Papadopoulos M, Lagona E, Papadimitriou A, Kanaka-Gantenbein C, Louizou E, Kastania A, Priftis
KN, Chrousos G (2012) Association of hypothalamic-pituitary-adrenal axis-related polymorphisms with stress in
asthmatic children on inhaled corticosteroids. Neuroimmunomodulation. 2012; 19(2):88-95. Epub 2012 Jan 11.
674.
Lambrou GI, Papadimitriou L, Chrousos GP, Vlahopoulos SA. (2012) Glucocorticoid and proteasome inhibitor
impact on the leukemic lymphoblast: Multiple, diverse signals converging on a few key downstream regulators. Mol
Cell Endocrinol. 2012 Jan 18. [Epub ahead of print]
54
George P. Chrousos, M.D.
675.
Al-Musharaf S, Al-Othman A, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, Al-Saleh Y, Al-Attas
OS, Alokail MS, Moharram O, Yakout S, Sabico S, Chrousos GP (2012) Vitamin D deficiency and calcium intake
in reference to increased body mass index in children and adolescents. Eur J Pediatr. 2012 Feb 7. [Epub ahead of
print]
676.
Tigani X, Artemiadis AK, Alexopoulos EC, Chrousos GP, Darviri C. (2012) Self-rated health in centenarians: A
nation-wide cross-sectional Greek study. Arch Gerontol Geriatr. 2012 Feb 21. [Epub ahead of print]
677.
Nader N, Ng SSM, Wang Y, Abel BS, Chrousos GP, Kino T (2012) Liver X Receptors Regulate the Transcriptional
Activity of the Glucocorticoid Receptor: Implications for the Carbohydrate Metabolism. PLoS ONE 7(3): e26751.
678.
Androutsos O, Grammatikaki E, Moschonis G, Roma-Giannikou E, Chrousos GP, Manios Y, Kanaka-Gantenbein
C. (2012) Neck circumference: a useful screening tool of cardiovascular risk in children. Pediatr Obes. 2012 Apr 13.
doi: 10.1111/j.2047-6310.2012.00052.x. [Epub ahead of print]
679.
Sällman Almén M, Rask-Andersen M, Jacobsson JA, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N,
Hedberg LA, Ignatovica V, Chrousos GP, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth
HB. Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted
sequencing in obese and lean children. Int J Obes (Lond). 2012 Apr 24. doi: 10.1038/ijo.2012.57. [Epub ahead of
print]
680.
Alfadda AA, Sallam RM, Chishti MA, Moustafa AS, Fatma S, Alomaim WS, Al-Naami MY, Bassas AF, Chrousos
GP, Jo H. Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: Adipose
depot specificity and gender dimorphism. Mol Cells. 2012 Apr 27. [Epub ahead of print]
681.
Pervanidou P, Bastaki D, Chouliaras G, Papanikolaou K, Laios E, Kanaka-Gantenbein C, Chrousos GP. Circadian
cortisol profiles, anxiety and depressive symptomatology, and body mass index in a clinical population of obese
children. Stress. 2012 Apr 30. [Epub ahead of print]
682.
Rask-Andersen M, Jacobsson JA, Moschonis G, Ek AE, Chrousos GP, Marcus C, Manios Y, Fredriksson R, Schiöth
HB. The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek
children. BMC Med Genet. 2012 May 17; 13(1):36. [Epub ahead of print]
683.
Al-Attas O, Al-Daghri N, Alokail M, Alkharfy K, Alfadda A, McTernan P, Gibson G, Sabico S, Chrousos G.
Circulating leukocyte telomere length is highly heritable among families of Arab descent. BMC Med Genet. 2012
May 18;13(1):38. [Epub ahead of print]
684.
Charmandari E, Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis
CA, Chrousos GP. (2012) A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and
Early-Onset Autosomal Dominant Hypertension. J Clin Endocrinol Metab. 2012 May 24. [Epub ahead of print]
685.
Tsaoussoglou M, Lianou L, Maragozidis P, Hatzinikolaou S, Mavromati M, Orologas N, PanaghiotopoulouGartagani P, Rassidakis G, Balatsos NA, Chrousos G, Kaditis AG. Cysteinyl leukotriene receptors in tonsillar Band T-lymphocytes from children with obstructive sleep apnea. Sleep Med. 2012 May 28. [Epub ahead of print]
686.
Johnson EO, Calogero AE, Konstandi M, Kamilaris TC, La Vignera S, Chrousos GP (2012) Effects of short- and
long-duration hypothyroidism on hypothalamic-pituitary-adrenal axis function in rats: In vitro and in situ studies.
Endocrine. 2012 Jun 14. [Epub ahead of print]
687.
Siahanidou T, Garatzioti M, Lazaropoulou C, Kourlaba G, Papassotiriou I, Kino T, Imura A, Nabeshima YI,
Chrousos G.Plasma soluble α-Klotho protein levels in premature and term neonates: Correlations with growth and
metabolic parameters. Eur J Endocrinol. 2012 Jun 19. [Epub ahead of print]
688.
Johnson EO, Kamilaris TC, Calogero AE, Konstandi M, Chrousos GP. Effects of Short- and Long-Duration
Hypothyroidism on Function of the Rat Hypothalamic-Pituitary-Adrenal Axis. J Endocrinol Invest. 2012 Jun 18.
[Epub ahead of print]
55
George P. Chrousos, M.D.
689.
Kritikou I, Basta M, Tappouni R, Pejovic S, Fernandez-Mendoza J, Nazir R, Shaffer M, Liao D, Bixler E, Chrousos
G, Vgontzas AN. (2012) Sleep apnoea and visceral adiposity in middle-aged males and females. Eur Respir J. 2012
Jun 27. [Epub ahead of print]
690.
Al-Othman A, Al-Musharaf S, Al-Daghri N, Krishnaswamy S, Yusuf D, Alkharfy K, Al-Saleh Y, Al-Attas O,
Alokail M, Moharram O, Sabico S, Chrousos G. Effect of physical activity and sun exposure on vitamin D status of
Saudi children and adolescents.BMC Pediatr. 2012 Jul 3;12(1):92. [Epub ahead of print]
691.
Al-Daghri NM, Alkharfy KM, Al-Othman A, El-Kholie E, Moharram O, Alokail MS, Al-Saleh Y, Sabico S, Kumar
S, Chrousos G. Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month
prospective interventional study. Cardiovasc Diabetol. 2012 Jul 18;11(1):85. [Epub ahead of print]
692.
Al-Daghri NM, Al-Othman A, Alkharfy KM, Alokail MS, Khan N, Alfawaz HA, Aiswaidan IA, Chrousos GP.
Assessment of selected nutrients intake and adipocytokines profile among Saudi children and adults.Endocr J. 2012
Jul 13. [Epub ahead of print]
693.
Moschonis G, Mavrogianni C, Karatzi K, Iatridi V, Chrousos GP, Lionis C, Manios Y. Increased physical activity
combined with more eating occasions is beneficial against dyslipidemias in children. The Healthy Growth Study.
Eur J Nutr. 2012 Aug 7. [Epub ahead of print]
694.
Al-Attas OS, Al-Daghri NM, Alokail MS, Alkharfy KM, Yakout S, Draz H, Sabico S, Chrousos GP Association of
body mass index, sagittal abdominal diameter and waist-hip ratio with cardiometabolic risk factors and
adipocytokines in arab children and adolescents. BMC Pediatr. 2012 Aug 7; 12(1):119. [Epub ahead of print]
695.
Spyridopoulos TN, Dessypris N, Antoniadis AG, Gialamas S, Antonopoulos CN, Katsifoti
K, Adami HO,
Chrousos GP, Petridou ET, Obesity and Cancer Oncology Group; Insulin resistance and risk of renal cell cancer: a
case-control study. Hormones (Athens). 2012 Jul; 11(3): 308-15.
696.
Al-Othman A, Al-Musharaf S, Al-Daghri NM, Yakout S, Alkharfy KM, Al-Saleh Y, Al-Attas OS, Alokail MS,
Moharram O, Sabico S, Kumar S, Chrousos GP. Tea and coffee consumption in relation to vitamin D and calcium
levels in Saudi adolescents. Nutr J. 2012 Aug 20; 11(1): 56. [Epub ahead of print]
697.
Papaioannou G, Kambas I, Tsaoussoglou M, Panaghiotopoulou-Gartagani P, Chrousos G, Kaditis AG. AgeDependent Changes in the Size of Adenotonsillar Tissue in Childhood: Implications for Sleep-Disordered Breathing.
J Pediatr. 2012 Aug 30. [Epub ahead of print]
698.
Al-Daghri NM, Al-Attas OS, Bindahman LS, Alokail MS, Alkharfy KM, Draz HM, Yakout S, McTernan PG,
Sabico S, Chrousos GP. Soluble CD163 is associated with body mass index and blood pressure in hypertensive
obese Saudi patients.Eur J Clin Invest. 2012 Jul 27. doi: 10.1111/j.1365-2362.2012.02714.x. [Epub ahead of print]
699.
Al-Saleh Y, Al-Daghri NM, Alkharfy KM, Al-Attas OS, Alokail MS, Al-Othman A, Sabico S, Chrousos GP (2012)
Normal Circulating PTH in Saudi Healthy Individuals with Hypovitaminosis D.Horm Metab Res. 2012 Sep 12.
[Epub ahead of print]
700.
Johnson EO, Calogero AE, Konstandi M, Kamilaris TC, Vignera SL, Chrousos GP (2012) Effects of experimentally
induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies.
Pituitary. 2012 Sep 14. [Epub ahead of print]
701.
Androutsellis-Theotokis A, Chrousos GP, McKay RD, Decherney AH, Kino T. (2012) Expression Profiles of the
Nuclear Receptors and Their Transcriptional Coregulators During Differentiation of Neural Stem Cells. Horm
Metab Res. 2012 Sep 18. [Epub ahead of print]
702.
Kouni S, Karakitsos P, Chranioti A, Theodoridou M, Chrousos G, Michos A (2012) Evaluation of viral co-infections
in hospitalized and non-hospitalized children with respiratory infections using microarrays. Clin Microbiol Infect.
2012 Sep 5. doi: 10.1111/1469-0691.12015. [Epub ahead of print]
56
George P. Chrousos, M.D.
703.
Papanastasiou L, Pappa T, Samara C, Apostolopoulou G, Tsiavos V, Markou A, Alexandraki K, Piaditis G,
Chrousos G, Kaltsas G. Nonalcoholic fatty liver disease in subjects with adrenal incidentaloma. Eur J Clin Invest.
2012 Nov;42(11):1165-72. doi: 10.1111/j.1365-2362.2012.02707.x. Epub 2012 Aug 1
704.
Aravidou E, Tsangaris G, Samara A, Dontas I, Botsis D, Aravidis C, Chrousos GP, Malamitsi-Puchner A. Aberrant
Expression of Collapsin Response Mediator Proteins -1, -2 and -5 in the Brain of Intrauterine Growth Restricted
Rats. Int J Dev Neurosci. 2012 Oct 17. pii: S0736-5748(12)00477-7. doi: 10.1016/j.ijdevneu.2012.10.004. [Epub
ahead of print]
705.
Pervanidou P, Akalestos A, Bastaki D, Apostolakou F, Papassotiriou I, Chrousos G. (2012) Increased circulating
High-Sensitivity Troponin T concentrations in children and adolescents with obesity and the metabolic syndrome: A
marker for early cardiac damage? Metabolism. 2012 Oct 29. doi:pii: S0026-0495(12)00358-7.
10.1016/j.metabol.2012.09.012. [Epub ahead of print]
706.
Dinopoulou V, Partsinevelos GA, Mavrogianni D, Anagnostou E, Drakakis P, Makrigiannakis A, Chrousos GP,
Loutradis D. The Effect of CRH and Its Inhibitor, Antalarmin, on in Vitro Growth of Preantral Mouse Follicles,
Early Embryo Development, and Steroidogenesis. Endocrinology 2012 Dec 4. [Epub ahead of print]
707.
Sertedaki A, Dracopoulou M, Voutetakis A, Stefanaki K, Rodogianni D, Magiakou AM, Kanaka-Gantenbein C,
Chrousos G, Dacou-Voutetakis C. Long-term Clinical Data and Molecular Defects in the StAR Gene in Five Greek
Patients. Eur J Endocrinol 2012 Dec 4. [Epub ahead of print
708.
Manios Y, Moschonis G, Chrousos GP, Lionis C, Mougios V, Kantilafti M, Tzotzola V, Skenderi KP, Petridou A,
Tsalis G, Sakellaropoulou A, Skouli G, Katsarou C. The double burden of obesity and iron deficiency on children
and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet. 2012 Dec 30. doi: 10.1111/jhn.12025.
[Epub ahead of print]
709.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Charalampidis P, Livadas S, Kollias A, Sabico SL,
Chrousos GP. Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances.
710.
Manios Y, Birbilis M, Moschonis G, Birbilis G, Mougios V, Lionis C, Chrousos GP; on behalf of the “Healthy
Growth Study” group. Childhood Obesity Risk Evaluation based on perinatal factors and family sociodemographic
characteristics: CORE Index. Eur J Pediatr 2013 Jan 10. [Epub ahead of print]
711.
Sarra A, Karantza M, Papaefthymiou M, Soultanakis H, Papaefstathiou A, Nikolaidou P, Bakoula C, Chrousos G.
Influence of developmental and hormonal factors on bone health in adolescent females: a cross-sectional study and
review of the literature. J Pediatr Endocrinol Metab. 2013 Jan 17:1-8. doi: 10.1515/jpem-2012-0355. [Epub ahead of
print]
712.
Alokail MS, Al-Daghri N, Abdulkareem A, Draz HM, Yakout SM, Alnaami AM, Sabico S, Alenad AM, Chrousos
GP. Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a
systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? BMC Cancer. 2013 Feb 4;
13(1):54. [Epub ahead of print]
713.
Settas N, Dracopoulou-Vabouli M, Dastamani A, Katsikis I, Chrousos G, Panidis D, Dacou-Voutetakis C (2013)
CYP21A2 Mutations in Women with Polycystic Ovary Syndrome (PCOS). Horm Metab Res. 2013 Feb 5. [Epub
ahead of print]
714.
Gika DM, Artemiadis AK, Alexopoulos EC, Darviri C, Chrousos GP, Papanikolaou K. Use of a relaxation
technique by mothers of children with autism: a case-series study. Psychol Rep. 2012 Dec; 111(3):797-804.
715.
Roberts ML, Kino T, Nicolaides NC, Hurt DE, Katsantoni E, Sertedaki A, Komianou F, Kassiou K, Chrousos GP,
Charmandari E. A Novel Point Mutation in the DNA-Binding Domain (DBD) of the Human Glucocorticoid
57
George P. Chrousos, M.D.
Receptor Causes Primary Generalized Glucocorticoid Resistance by Disrupting the Hydrophobic Structure of its
DBD. J Clin Endocrinol Metab. 2013 Feb 20. [Epub ahead of print]
716.
Katsarou AL, Vryonis MM, Protogerou AD, Alexopoulos EC, Achimastos A, Papadogiannis D, Chrousos GP,
Darviri C. Stress management and dietary counseling in hypertensive patients: a pilot study of additional effect.
Prim Health Care Res Dev. 2013 Feb 21:1-8 [Epub ahead of print]
717.
Bougea AM, Spandideas N, Alexopoulos EC, Thomaides T, Chrousos GP, Darviri C. Effect of the emotional
freedom technique on perceived stress, quality of life, and cortisol salivary levels in tension-type headache sufferers:
a randomized controlled trial. Explore (NY). 2013 Mar;9 (2):91-9. doi: 10.1016/j.explore.2012.12.005.
718.
Giannouli G, Tzoumaka-Bakoula C, Kopsidas I, Papadogeorgou P, Chrousos GP, Michos A. Epidemiology and
Risk Factors for Coronary Artery Abnormalities in Children With Complete and Incomplete Kawasaki Disease
During a 10-Year Period. Pediatr Cardiol. 2013 Mar 6. [Epub ahead of print]
719.
Markou A, Pappa T, Kaltsas G, Gouli A, Mitsakis K, Tsounas P, Prevoli A, Tsiavos V, Papanastasiou L, Zografos
G, Chrousos GP, Piaditis GP. Evidence of Primary Aldosteronism in a Predominantly Female Cohort of
Normotensive Individuals: A Very High Odds Ratio for Progression into Arterial Hypertension. J Clin Endocrinol
Metab. 2013 Mar 7. [Epub ahead of print]
720.
Tatsi C, Sertedaki A, Voutetakis A, Valavani E, Magiakou MA, Kanaka-Gantenbein C, Chrousos GP, DacouVoutetakis C. Pituitary Stalk Interruption Syndrome and Isolated Pituitary Hypoplasia May Be Caused by Mutations
in Holoprosencephaly-Related Genes.J Clin Endocrinol Metab. 2013 Mar 8 [Epub ahead of print]
721.
Sakka SD, Margeli A, Loutradis D, Chrousos GP, Papassotiriou I, Kanaka-Gantenbein C. Gender dimorphic
increase in RBP-4 and NGAL in children born after IVF: an epigenetic phenomenon? Eur J Clin Invest. 2013 Feb
20. doi: 10.1111/eci.12066. [Epub ahead of print]
722.
Tatsi C, Kanaka-Gantenbein C, Vazeou-Gerassimidi A, Chrysis D, Delis D, Tentolouris N, Dacou-Voutetakis C,
Chrousos GP, Sertedaki A. The spectrum of HNF1A gene mutations in Greek patients with MODY3: relative
frequency and identification of seven novel germline mutations. Pediatr Diabetes. 2013 Mar 21. doi:
10.1111/pedi.12032. [Epub ahead of print]
723.
Moschonis G, Kalliora AC, Costarelli V, Papandreou C, Koutoukidis D, Lionis C, Chrousos GP, Manios
Y.Identification of lifestyle patterns associated with obesity and fat mass in children: the Healthy Growth Study.
Public Health Nutr. 2013 Mar 26:1-11. [Epub ahead of print]
724.
Kritikou I, Basta M, Vgontzas AN, Pejovic S, Liao D, Tsaoussoglou M, Bixler E, Stefanakis Z, Chrousos G. Sleep
Apnea, Sleepiness, Inflammation and Insulin Resistance in middle-aged Men and Women. Eur Respir J. 2013 Apr
18. [Epub ahead of print]
725.
Manti P, Giannakopoulos G, Giouroukou E, Georgaki-Angelaki H, Stefanidis CJ, Mitsioni A, Stergiou N, Mihas C,
Chrousos GP, Magiakou MA, Kolaitis G. Psychosocial and cognitive function in children with nephrotic syndrome:
association with disease and treatment variables. Biopsychosoc Med. 2013 Apr 23;7 (1):10. [Epub ahead of print]
726.
Christaki E, Kokkinos A, Costarelli V, Alexopoulos EC, Chrousos GP, Darviri C. Stress management can facilitate
weight loss in Greek overweight and obese women: a pilot study.J Hum Nutr Diet. 2013 Apr 30. doi: 10.1111/
jhn.12086. [Epub ahead of print]
727.
Bahijri S, Borai A, Ajabnoor G, Abdul Khaliq A, Alqassas I, Al-Shehri D, Chrousos G. Relative Metabolic
Stability, but Disrupted Circadian Cortisol Secretion during the Fasting Month of Ramadan. PLoS One. 2013 Apr
18;8(4):e60917. doi: 10.1371/journal.pone.0060917. Print 2013.
728.
Moschonis G, Mougios V, Papandreou C, Lionis C, Chrousos GP, Malandraki E, Manios Y. "Leaner and less fit"
children have a better cardiometabolic profile than their "heavier and more fit" peers: The Healthy Growth Study.
Nutr Metab Cardiovasc Dis. 2013 May 13. doi:pii: S0939-4753(12)00280-3. 10.1016/j.numecd.2012.11.010. [Epub
58
George P. Chrousos, M.D.
729.
Kalampouka E, Moudaki A, Malakasioti G, Panaghiotopoulou-Gartagani P, Chrousos G, Kaditis AG. Family
history of adenotonsillectomy as a risk factor for tonsillar hypertrophy and snoring in childhood. Pediatr Pulmonol.
2013 Jun 17. doi: 10.1002/ppul.22830. [Epub ahead of print]
730.
Dimitriadou E, Noutsopoulos D, Markopoulos G, Vlaikou AM, Mantziou S, Traeger-Synodinos J, Kanavakis E,
Chrousos GP, Tzavaras T, Syrrou M. Abnormal DLK1/MEG3 imprinting correlates with decreased HERV-K
methylation after assisted reproduction and preimplantation genetic diagnosis. Stress. 2013 Jun 21. [Epub ahead of
print]
731.
Karatzas T, Vasileiadis I, Kapetanakis S, Karakostas E, Chrousos G, Kouraklis G. Risk factors contributing to the
difference in prognosis for papillary versus micropapillary thyroid carcinoma. Am J Surg. 2013 Jun 19. doi:pii:
S0002-9610(13)00302-4. 10.1016/j.amjsurg.2013.02.008. [Epub ahead of print]
732.
Christaki E, Kokkinos A, Costarelli V, Alexopoulos EC, Chrousos GP, Darviri C Stress management can facilitate
weight loss in Greek overweight and obese women: a pilot study. J Hum Nutr Diet. 2013 Jul;26 Suppl 1:132-9. doi:
10.1111/jhn.12086. Epub 2013 Apr 30.
733.
Miranda J, Romero R, Korzeniewski SJ, Chaemsaithong P, Stampalija T, Yeo L, Dong Z, Hassan SS, Chrousos GP,
Gold P, Chaiworapongsa T. The Anti-aging Factor α-klotho during Human Pregnancy and its Expression in
Pregnancies Complicated by Small for Gestational Age Neonates and/or Preeclampsia. J Matern Fetal Neonatal
Med. 2013 Jul 1. [Epub ahead of print]
734.
Chouliaras G, Panayotou I, Margoni D, Mantzou E, Pervanidou P, Manios Y, Chrousos GP, Roma E
Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn's
disease and ulcerative colitis. Pediatr Res. 2013 Jul 3. doi: 10.1038/pr.2013.114. [Epub ahead of print]
PMID: 23823177
735.
Kalaitzidou I, Venetikou MS, Konstadinidis K, Artemiadis AK, Chrousos G, Darviri C. Stress
management and erectile dysfunction: a pilot comparative study. Andrologia. 2013 Jul 3. doi:
10.1111/and.12129. [Epub ahead of print]
736.
Tzifi F, Kanariou M, Tzanoudaki M, Mihas C, Paschali E, Chrousos G, Kanaka-Gantenbein C. Flow cytometric
analysis of the CD4+ TCR Vbeta repertoire in the peripheral blood of children with type 1 diabetes mellitus,
systemic lupus erythematosus and age-matched healthy controls. BMC Immunol. 2013 Aug 3;14(1):33. [Epub ahead
of print]
737.
Alkharfy K, Al-Daghri N, Sabico S, Al-Othman A, Moharram O, Alokail M, Al-Saleh Y, Kumar S, Chrousos G
Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year
prospective study Cardiovascular Diabetology 2013, 12:113 (7 August 2013)
738.
Papatheodorou DC, Karagiannidis LK, Paltoglou G, Margeli A, Kaparos G, Valsamakis G, Chrousos GP, Creatsas
G, Mastorakos G. Pulsatile interleukin-6 leads CRH secretion and is associated to myometrial contractility during
the active phase of term human labor. J Clin Endocrinol Metab. 2013 Aug 8. [Epub ahead of print]
739.
Krikri A, Alexopoulos V, Zoumakis E, Katsaronis P, Balafas E, Kouraklis G, Karayannacos PE, Chrousos GP,
Skalkeas G. Laparoscopic vs. open abdominal surgery in male pigs: Marked differences in cortisol and
catecholamine response depending on the size of surgical incision. Hormones (Athens). 2012 Apr;12(2):283-91
740.
Pejovic S, Basta M, Vgontzas AN, Kritikou I, Shaffer ML, Tsaoussoglou M, Stiffler D, Stefanakis Z, Bixler EO,
Chrousos GP.The Effects of Recovery Sleep after One Workweek of Mild Sleep Restriction on Interleukin-6 and
Cortisol Secretion and Daytime Sleepiness and Performance. Am J Physiol Endocrinol Metab. 2013 Aug 13. [Epub
ahead of print]
59
George P. Chrousos, M.D.
741.
Rask-Andersen M, Moschonis G, Chrousos GP, Marcus C, Dedoussis GV, Fredriksson R, Schiöth HB. The STK33Linked SNP rs4929949 Is Associated with Obesity and BMI in Two Independent Cohorts of Swedish and Greek
Children.PLoS One. 2013 Aug 15;8(8):e71353. doi: 10.1371/journal.pone.0071353
742.
Xekouki P, Mastroyiannis SA, Avgeropoulos D, de la Luz Sierra M, Trivellin G, Gourgari EA, Lyssikatos C,
Quezado M, Patronas N, Kanaka-Gantenbein C, Chrousos GP, Stratakis CA.Familial pituitary apoplexy as the only
presentation of a novel AIP mutation. Endocr Relat Cancer. 2013 Sep 11;20(5):L11-4. doi: 10.1530/ERC-13-0218.
743.
Gialamas SP, Sergentanis TN, Antonopoulos CN, Dessypris N, Chrousos GP, Petridou ET.Circulating
leptin levels and risk of colorectal cancer and adenoma: a case-control study and meta-analysis. Cancer
Causes Control. 2013 Oct 2. [Epub ahead of print]
744.
Metheniti D, Sakka S, Dracopoulou M, Margeli A, Papassotiriou I, Kanaka-Gantenbein C, Chrousos GP,
Pervanidou P. Decreased circulating 25-(OH) Vitamin D concentrations in obese female children and adolescents:
Positive associations with Retinol Binding Protein-4 and Neutrophil Gelatinase-associated Lipocalin. Hormones
(Athens). 2012 Jul;12(3):397-404.
745.
Papastamataki M, Papassotiriou I, Bartzeliotou A, Vazeou A, Roma E, Chrousos GP, Kanaka-Gantenbein C.
Incretins, Amylin and Other Gut-Brain Axis Hormones in Children with Celiac Disease. Eur J Clin Invest. 2013 Oct
24. doi: 10.1111/eci.12193. [Epub ahead of print]
746.
Alexopoulos EI; Theologi V; Malakasioti G; Maragozidis P; Tsilioni I; Chrousos G; Gourgoulianis K; Kaditis AG.
Obstructive sleep apnea, excessive daytime sleepiness, and morning plasma TNF-α levels in Greek children. SLEEP
2013; 36 (11):1633-1638.
747.
Al-Daghri NM, Alkharfy KM, Rahman S, Amer OE, Vinodson B, Sabico S, Milan P, Harte AL, McTernan PG,
Alokail MS, Chrousos GP. Irisin as a Predictor of Glucose Metabolism in Children: Sexually Dimorphic Effects.
Eur J Clin Invest. 2013 Nov 5. doi: 10.1111/eci.12196. [Epub ahead of print]
B. REVIEWS-CHAPTERS-LETTERS (*PEER REVIEWED)
1.
Moutsopoulos H.M., Chrousos G.P., Papavassiliou J.T. (1976) Autoimmunity and Slow Viruses. Materia Medica
Graeca, 4, (1), 76-84.
2.
Moutsopoulos H.M., Chrousos G.P., Papavassiliou J.T. (1976) Humoral Thymic Products (ThymosinThymopoietin): Reality and Perspective. Materia Medica Graeca, 4, (1), 85-89.
3.
Chrousos G.P. (1976) Bacteriocinogeny in Salmonellae. Doctorate Thesis, Athens University.
4.
Karatzas N.B., Chrousos G.P. (1976) The Adrenergic Neurochemical Transmission and the Drugs that Influence It.
Iatriki, 30: 311-325.
5.
Chrousos G.P., Karatzas N.B. (1977) The Systolic Intervals In Hemodialysis. Changes Related to Starling's Law.
Hellenic Cardiological Review (Athens), 18: 225-231.
6.
Papadoyiannis D.E., Clouvas P., Chrousos G.P., Karatzas N.B. (1977) A Blind Comparative Trial of a Beta-Blocker
(timolol), a Diuretic and a Combination of the Two in the Treatment of Hypertension. Iatriki, 32: 391-395.
7.
Chrousos G.P., Karatzas N.B. (1977) The Problem Oriented System and Its Usefulness. Iatriki, 31: 348352.
8.
Cornblath M.D., Chrousos G.P., Adams A. (1979) Hormone Interactions and Glucose Homeostasis.
Paediatrica Belg. 32: 231-238.
9.
Chrousos G.P., Greydanus D. (1981) Adolescent Medicine: Necessity and Perspectives. Iatriki 40: 252-257.
Acta
60
George P. Chrousos, M.D.
10.
Chrousos G.P., Cutler G.B., Simons S., Pons M., Moriarty R.M., Loriaux D.L. (1982) Development of
Antiglucocorticoids with Potential Clinical Usefulness. In: Progress in Research and Clinical Applications of
Corticosteroids, Eds. H.J. Lee, and T.J. Fitzerald, Heyden and Son Co., Philadelphia, p. 152-156.
11.
Lipsett M.B., Chrousos G.P., Loriaux D.L. (1982) Glucocorticoid Receptor Defects: Studies in Humans and a
Primate Model in "Proceedings of the International Symposium on Hormone Receptors and Receptor Diseases."
Excerpta Medica, Amsterdam, H. Imura and H. Kuzua (Eds.) p. 187-193.
12.
Chrousos G.P., Munabi A., Cutler G.B. Jr., Loriaux D.L. (1982) Diagnosis of Late-Onset 21- Hydroxylase
Deficiency by Plasma 17-Hydroxyprogesterone Response to ACTH. Ann. Int. Med. (Letter to the Editor) 97: 281282.
13.
Chrousos G.P., Loriaux D.L., Brandon D., Merriam G.R., Johnson E.O., Lipsett M.B. (1983) Primary Cortisol
Resistance: A Familial Syndrome and an Animal Model. J. Steroid Biochem. 19: 567-576.
14.
Chrousos G.P., Cutler G.B. Jr., Sauer M., Simons S.S. Jr., Loriaux D.L. (1983) Development of Glucocorticoid
Antagonists: Pharmacol. Ther. 20(2): 263-281.
15.
Chrousos G.P. (1983) Pathophysiology of the Endocrine Glands. In: "Basic Principles of Pathophysiology" Eds.
H.M. Moutsopoulos and D.S. Emmanuel, Litsas Press, Athens. p. 116-168.
16.
Chrousos G.P., Schulte H.M., Loriaux D.L., Cutler G.B. Jr., Gold P.W. (1983) Corticotropin Releasing Factor:
Basic and Clinical Studies. Psychopharmacol. Bull. 19: 416-421.
17.
Becker L., Gold P.W., Chrousos G.P. (1983) Analogies betweeen Cushing's Disease and Depression: A Case
Report. General Hospital Psychiatry. 5: 89-91.
18.
*Schulte H.M., Chrousos G.P., Chatterji D.C., Gold P.W., Oldfield E.H., Loriaux D.L. (1983)
Corticotropin-Releasing Factor. The Lancet Vol. I (o 8335) p. 1222 (Letter to the Editor).
19.
Healy D.L., Hall N.R., Schulte H.M., Chrousos G.P., Goldstein A.L., Loriaux D.L., Hodgen G.H. (1984) Pituitary
Responses to Acute Administration of Thymosin in Prepubertal Primates. In: "Thymic Hormones and
Lymphokines, Ed. Alan Goldstein, Plenum Press, New York, p. 365-374.
20.
*Gold P.W., Chrousos G.P., Kellner C., Post R., Schulte H., Oldfield E.H., Loriaux D.L. (1984) Basic and Clinical
Studies with Corticotropin Releasing Factor: Psychiatric Implications. Am. J. Psychiatry. 141: 619 627.
21.
Chrousos G.P., Tomita M., Brandon D., Loriaux D.L., Lipsett M.B. (1984) Glucocorticoid Insensitivity in Man and
Nonhuman Primates. In: Labrie, F. and Prouix, L. (Eds.) Proceedings of the 7th International Congress of
Endocrinology, Elsevier Science Pub., Amsterdam. p. 853-856.
22.
Crawley J.N., Ninan P.T., Pickar D., Chrousos G.P., Scolnick P., Paul S.M. (1984) Behavioral and A Physiological
Responses to Benzodiazepine Receptor Antagonists. Psychopharmacol. Bull. 20: 403-407.
23.
Schulte H.M., Chrousos G.P., Reinwein D., Loriaux D.L. (1984) Der Kortikotropin-Releasing- Faktorstimulationstest inder Differential diagnose des Cushing-Syndroms. Verhandlungender Deutschen Gesellschaft fur Innere
Medizin. Endokrinologie II. 90: 508-511.
24.
Chrousos G.P., Nieman L., Nisula B., Schulte H.M., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1984)
Corticotropin-releasing Factor Stimulation Test. (Letter to the Editor) N. Engl. J. Med. 311:472-473.
25.
Chrousos G.P., Nieman L., Healy D., Spitz I., Cutler G.B. Jr., Brandon D., Merriam G.R., Hodgen G., Bardin C.W.,
Loriaux D.L. (1984) Antiglucocorticoids: General Aspects and Clinical Implications. In: Glucocorticoids:
Research and Therapy. Eds. H. Fehm, J. Kobberling, and H. Kruskemper Perimed Fachbush, Verlagsgesellschaft,
Erlangen. p. 54-71.
Safety of
61
George P. Chrousos, M.D.
26.
Chrousos G.P., Calabrese J.R., Loriaux D.L., Schuermeyer T., Avgerinos P., Cutler G.B. Jr., Gold P.W. (1985)
Corticotropin Releasing Factor: Basic Studies and Clinical Implications. Prog. in Neuro-Psychopharmacol. and
Biol. Psychiat. 9: 349-359.
27.
Hall N., McGillis J.P., Spangelo B.L., Healy D.L., Chrousos G.P., Schulte H.M., Goldstein A.L.(1985) Thymic
Hormone Effects on the Brain and Neuroendocrine Circuits. In: Neural Modulation of Immunity. Eds. R.
Guillemen, M. Cohen and T. Melnechuk, Raven Press, New York p. 179-193.
28.
Lipsett M.B., Chrousos G.P., Brandon D.D., Tomita M., Loriaux D.L. (1985)
Receptor in Man and Nonhuman Primates. Rec. Prog. Horm. Res. 41: 199-247.
29.
Udelsman R., Gallucci T.W., Gold P.W., Renquist D.L., Loriaux D.L., Chrousos G.P. (1985) Human Corticotropin
Releasing Hormone as a Vasodilator Causing Systemic Hypotension. In: The Adrenal Gland and Hypertension. F.
Mantero, Biglieri E., Funder, J. and Scoggins, B. (Eds) Serono Symposia Series, Vol. 27, Raven Press, New York,
219-224.
30.
*Gold P.W., Chrousos G.P. (1985) Clinical Studies with Corticotropin Releasing Factor: Implications for the
Diagnosis and Pathophysiology of Depression, Cushing's Disease and Adrenal Insufficiency. Psychoneuroendocrinology (awarded the Kurt Richter Prize for Psychoneuro-endocrinology) 10: 401-419.
31.
Chrousos G.P., Evans M., McCluskey J., Fletcher J., Loriaux D.L., Schulman J. (1985) Prenatal Treatment of
Congenital Adrenal Hyperplasia. Annals of the New York Academy of Sciences, New York, NY. 458: 156-164
32.
Nieman L.K., Chrousos G.P., Kellner C., Spitz I., Nisula B.C., Cutler G.B. Jr., Merriam G.R., Bardin C.W., Loriaux
D.L. (1985) Use of the Glucocorticoid Antagonist RU 486 in the Treatment of Cushing's Syndrome. In: The
Antiprogestin Steroid RU 486 and Human Fertility Control. Eds. S.J. Segal and E.E. Baulieu. Plenum Press, New
York. 339-345.
33.
Nieman L.K., Healy D., Spitz I., Merriam R., Bardin C.W., Loriaux D.L., Chrousos G.P. (1985) Use of Single
Doses of the Antiprogesterone Steroid RU 486 for Induction of Menstruation in Normal Women. In: The
Antiprogestin Steroid RU 486 and Human Fertility Control. Eds. S.J. Segal and E.E. Baulieu. Plenum Press, New
York 279-283.
34.
Nottelman E.D., Susman E.J., Blue J.H., Inoff G.E., Dorn L.D., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1985)
Gonadal and Adrenal Hormone Correlates of Adjustment in Early Adolescence. In: Biological-psychosocial
Interactions in Early Adolescence: A Life-span Perspective. Eds. R.M. Lerner and T.T. Foch. Erlbaum, Hillsdale,
N.J. p. 303-323.
35.
Oldfield E.H., Chrousos G.P., Nieman L.K., Schaaf M., Cutler G.B. Jr., Loriaux D.L., Doppman J.L. (1985) Inferior
Petrosal Venous Sampling in Lateralization of ACTH-secreting Pituitary Microadenomas. N. Engl. J. Med. (Letter
to the Editor) 312: 1457-1458.
36.
Udelsman R., Loriaux D.L., Chrousos G.P. (1985) Reevaluation of the Role of Glucocorticoids in Surgical Stress.
Surgical Forum 36: 18-20.
37.
Gold P.W., Kling M., Calabrese J.R., Gallucci W.T. Kellner C.H., Post R.M., Cutler G.B., Avgerinos P.C., Loriaux
D.L., Chrousos G.P. (1985) Clinical Applications of Corticotropin Releasing Factor. In: Nemeroff, C.B., (Ed):
Handbook of Clinical Neuroendocrinology. Raven Press, New York.
38.
*Chrousos G.P., Schuermeyer T., Oldfield E., Doppman J., Schulte H.M. Gold P.W., Loriaux D.L. (1985) The
Clinical Applications of Corticotropin-Releasing Factor. A Conference of the Combined Clinical Staff of the
National Institutes of Health. Ann. Int. Med. 102: 344-358.
39.
Lipsett M.B., Tomita M., Brandon D., Loriaux D.L., Chrousos G.P. (1986) Cortisol Resistance in Man. In:
Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (Eds) Steroid Hormone Resistance: Mechanisms and Clinical
Aspects. Plenum Press, New York, p. 97-110.
The Defective Glucocorticoid
62
George P. Chrousos, M.D.
40.
Winterer J., Chrousos G.P., Loriaux D.L., Cutler G.B. (1986) The Adrenal Suppressive Effect of Hydrocortisone in
Congenital Adrenal Hyperplasia. Annals of the New York Academy of Sciences, New York, NY 458: 182-192.
41.
Lipsett M.B., Chrousos G.P., Loriaux D.L. (1986) The Steroid Binding Proteins in the Syndrome of Glucocorticoid
Resistance and in New World Primates. In: The Role of Receptors in Biology and Medicine. B. O'Malley and A.
Gotto (Eds). Raven Press, New York p. 51-61.
42.
Chrousos G.P., Loriaux D.L., Tomita M., Brandon D., Lipsett M.B. (1986) The New World Primates as Animal
Models of Cortisol Resistance. In: Chrousos G.P., Loriaux D.L., Lipsett M.B., (Eds). Steroid Hormone Resistance:
Mechanisms and Clinical Aspects, Plenum Press, New York, p. 129-144.
43.
Chrousos G.P., Loriaux D.L. (1986) Cushing's Syndrome. In: Conn's Current Therapy. Ed. Robert E. Rakel, W.B.
Saunders Co., Philadelphia p. 499-502.44. Gold P.W., Calabrese J., Kling M., Avgerinos P., Khan I., Gallucci W.T.,
Tomai T., Chrousos G.P. (1986) Abnormal Pituitary-Adrenal Responses to Corticotropin Releasing Factor in
Depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 10: 57-65.
44.
Winterer J., Cutler G.B. Jr., Chrousos G.P., Feuillan P.P., Loriaux D.L. (1986) Management of CongenitalAdrenal
Hyperplasia. J. Pediatrics (Letter to the Editor) 109: 389-90.
45.
Chrousos G.P., Maclusky N. Brandon D., Tomita M., Loriaux D.L., Lipsett M.B. (1986) Progesterone Resistance.
In: Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (Eds). Steroid Hormone Resistance: Mechanisms and Clinical
Aspects, Plenum Press, New York, p. 317-328.
46.
Gold P.W., Kling M., Calabrese J., Kellner C., Roy A., Gwirtsman H., Post R.M., Pickar D., Avgerinos P.C.,
Loriaux D.L., Chrousos G.P. (1987) Corticotropin Releasing Factor in the Pathophysiology of Hypercortisolism in
Depression. In: Hormones and Depression, U. Halbreich (Ed) Raven Press, New York. 77-89.
47.
Chrousos G.P., Loriaux D.L. (1987) Cushing's Syndrome. In: Conn's Current Therapy. Ed. Robert E. Rakel. W.B.
Saunders Co., Philadelphia p. 495-498.
48.
Susman E., Nottelman E., Inoff G., Dorn L., Chrousos G.P. (1987)
Psychological Development. J. Adol. Health Care 8: 492-504.
49.
Chrousos G.P., Luger A., Avgerinos P.C., Kling M., Oldfield E., Nieman L.K., Schuermeyer T., Loriaux D.L., Gold,
P.W. (1987) Corticotropin Releasing Hormone: Relevance to Physiology and Pathophysiology. In: Recent
Advances in Adrenal Regulation and Function, Raven Press, New York, 121-135.
50.
Nieman L.K., Udelsman R., Loriaux D.L. and G.P. Chrousos (1987) Antiglucocorticoids:. In: Recent Advances in
Adrenal Regulation and Function. Raven Press, New York, 235-242.
51.
Udelsman R., Loriaux D.L., Chrousos G.P. (1987) Surgical Stress: The Role of Glucocorticoids and
Catecholamines. In: D'Agata R., and G.P. Chrousos (Eds) Recent Advances in Adrenal Regulation and Function.
Raven Press, New York, 253-263.
52.
Calogero A., Gallucci W., Tomai T., Loriaux D.L., Chrousos, G.P., P.W. Gold (1987) The GABA/Benzodiazepine
System is Involved in the Regulation of Hypothalamic CRH Secretion In Vitro. In: D'Agata R., and Chrousos G.P.
(Eds) Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 279-284.
53.
Gold P.W., Kling M.A., Calabrese J.R., Post R.M., Roy A., Nieman L.K., Cutler G.B. Jr., Loriaux D.L. Chrousos
G.P. (1987) Corticotropin Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease.
(Letter to the Editor) N. Engl. J. Med. 316: 218-219.
54.
Laue L., Chrousos G.P. (1987) Antiinflammatory Steroid Action: Receptor-mediated Effects on Prostanoid
Synthesis. In: D'Agata R. and G.P. Chrousos (Eds). Recent Advances in Adrenal Regulation and Function. Raven
Press, New York, 293-302.
55.
Gold P.W., Gwirtsman H., Brandt H., Jimerson D., Loriaux D.L., Chrousos G.P. (1987) Abnormal Hypothalamic
Hormonal Influences on Aspects of
63
George P. Chrousos, M.D.
Pituitary-Adrenal Function in Anorexia Nervosa. (Letter) N.Engl. J. Med. 316: 219-220.
56.
Gold P.W., Kling M.A., Khan J., Calabrese J.R., Kalogeras K., Post R.M., Avgerinos P., Loriaux D.L. and G.P.
Chrousos (1987) Corticotropin Releasing Hormone: Relevance to Normal Physiology and to the Pathophysiology
and Differential Diagnosis of Hypercortisolism and Adrenal Insufficiency. In: Hypothalamic Dysfunction in
Neuropsychiatric Disorders. Eds. D. Nerozzi, F.K. Goodwin and E. Costa. In the series: Advances in Biochemical
Psychopharmacology, Vol 43, Raven Press, NY pp. 183-200.
57.
Schürmeyer T.H., Schulte H.M., Avgerinos P., Tomai T.P., Loriaux D.L., Gold P.W., Chrousos G.P. (1987)
Pharmacology of Ovine and Human CRH. Horm. Metabol. Res. 16: 24-30.
58.
Avgerinos P., Schuermeyer T., Udelsman R., Nieman L.K., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) Human
Corticotropin Releasing Factor as a Tool for Studying the Pulsatile Function of the Hypothalamic-pituitary-adrenal
Axis. In: W. Crowley and J.F. Hofler (Eds) Episodic Hormone Secretion: Methods of Analysis and Normative
Data. Churchill Livingstone, New York p. 389-401.
59.
Peacock J., Laue L., Chrousos G.P., Gallucci W., Norton N. (1987) Glucocorticoid Receptor Mediates Rat Sarcoma
Growth. Surgical Forum 38: 396-398.
60.
*Gold P.W., Goodwin F., Chrousos, G.P. (1988) Clinical and Biochemical Manifestations of Depression:
Relationship to the Neurobiology of Stress. (Part I) N. Engl. J. Med. 319: 348-353.
61.
Chrousos G.P. (1988) Endocrine Tumors, In: Pizzo P.A. and Poplack D.G. (Eds) Principles and Practice of
Pediatric Oncology. J.B. Lippincott Co., New York. 733-757.
62.
Chrousos G.P., Loriaux D.L. (1988) Cushing's Syndrome. In: Conn's Current Therapy, Ed. R.E. Rakel, W.B.
Saunders Co., New York. 525-529.
63.
Margioris A., Grino M., Gold P.W., Rabin D., Chrousos G.P. (1988) Human Placenta and the Hypothalamicpituitary-adrenal Axis. In: Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv.
Exp. Med. Biol. 245: 389-398.
64.
Chrousos G.P., Loriaux D.L., Gold P.W. (1988) The Concept of Stress and Its Historical Development. In:
Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv. Exp. Med. Biol. 245: 3-7.
65.
Rabin D., Gold P.W., Margioris A., Chrousos G.P. (1988) Stress and Reproduction: Interactions Between the Stress
and Reproductive Axes. In: Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv.
Exp. Med. Biol. 245: 377-387.
66.
Nieman L.K., Loriaux D.L., Chrousos G.P. (1988) Corticotropin Releasing Factors. In: Central Nervous System
Endocrinology. M. Cohen and P. Foa (Eds). Springer-Verlag Co., New York, NY 14-45.
67.
Bernardini R., Luger A., Gold P.W., Chiarenza A., Legakis J., Chrousos G.P. (1988) Cytokines Stimulate Pituitaryadrenal Function via Activation of the CRH Neuron. In: New Trends in Brain and Female Reproductive Function.
F. Petraglia (Ed) CIG Edizioni Internationali, Milan p. 35-39.
68.
Chrousos G.P., Laue L., Kawai S., Nieman L.K., Udelsman R., Loriaux D.L.(1988) Glucocorticoids and
Glucocorticoid Antagonists: Lessons from RU 486. Kidney International Vol. 34, Suppl 26, p. S-18-S-23.
69.
Laue L., Loriaux D.L., Chrousos G.P. (1988) Glucocorticoid Antagonists and the Role of Glucocorticoids at the
Resting and Stress State. In: Chrousos G.P., Loriaux D.L. and Gold P.W. (Eds) Mechanism of Physical and
Emotional Stress. Plenum Press, New York, NY. Adv. Exp. Med. Biol. 245: 225-235.
70.
Gold P.W., Pigott T.A., Kling M.K., Kalogeras K., Chrousos G.P. (1988) Basic and Clinical Studies with
Corticotropin Releasing Hormone: Implications for a Possible Role in Panic Disorder. Psychiatr. Clin. North
America Vol. 11(2) 327-334.
64
George P. Chrousos, M.D.
71.
Calogero A., Bernardini R., Gold P.W., Chrousos G.P. (1988) Regulation of CRH Secretion in Vitro: Potential
Clinical Implications. In: Mechanisms of Physical and Emotional Stress. Plenum Publ., New York. Adv. Exp.
Med. Biol. 245: 167-181.
72.
Udelsman R., Chrousos G.P. (1988) Hormonal Response to Surgical Stress. In: Mechanisms of Physical and
Emotional Stress. Plenum Publ., New York. Adv. Exp. Med. Biol. 245: 267-272.
73.
Luger A., Deuster P.A., Gold P.W., Loriaux D.L., Chrousos G.P. (1988) Hormonal Responses to the Stress of
Exercise. Adv. Med. Biol. 245: 273-283.
74.
Susman E.J., Nottelman E.D., Dorn L.D., Inoff-Germain G., Chrousos G.P. (1988) Physiological and Behavioral
Aspects of Stress in Adolescence. In: Mechanisms of Physical and Emotional Stress. Plenum Press New York.
Adv. Exp. Biol. Med. 245: 341-352.
75.
Gold P.W., Whitfield H.J., Kling M.A., Demitrack M.A., Brandt H.A., Chrousos G.P. (1988) The Relevance of
Corticotropin Releasing Hormone to Normal Physiology and to Pathophysiology of Adrenal Function. In A.F.
Schatzberg and C.B. Nemeroff (eds) The Hypothaamic-Pituitary-Adrenal Axis. Physiology, Pathophysiology and
Psychiatric Implications. Raven Press, New York, p. 101-113.
76.
Gold P.W., Kling M.A., Demitrack M., Whitfield H.J., Kalogeras K., Loriaux D.L., Chrousos G.P. (1988) Clinical
Studies with Corticotropin Releasing Hormone: Implications for Hypothalamic-Pituitary-Adrenal Dysfunction in
Depression and Related Disorders. In: Ganten D., and Pfaff D. (eds) Neuroendocrinology of Mood. Current Topics
in Endocrinology Vol. 8, Springer-Verlag, New York p. 55-77.
77.
Gold P.W., Kling M., Whitfield H., Rabin D., Margioris A., Kalogeras D., Demitrack M., Loriaux D.L., Chrousos
G.P. (1988) The Clinical Implications of Corticotropin Releasing Hormone. In: Mechanisms of Physical and
Emotional Stress. Plenum Publ. New York. Adv. Exp. Biol. Med. 245: 507-519.
78.
Brandon D.D., Markwick A., Chrousos G.P., Loriaux D.L. (1988) Glucocorticoid Resistance in a Family and New
World Primates. Cancer Res. (suppl). 49: 2203S-2213S.
79.
*Gold P.W., Goodwin F.K., Chrousos G.P. (1988) Clinical and Biochemical Manifestations of Depression:
Relationship to the Neurolobiology of Stress. (Part 2). N. Engl. J. Med. 319: 413-420.
80.
Laue L., Kawai S., Udelsman R., Nieman L.K., Brandon D.D., Gallucci W.T., Gold P.W., Loriaux D.L., Chrousos
G.P. (1989) Glucocorticoid Antagonists: Pharmacological Attributes of the Prototype Antiglucocorticoid RU 486.
Chapter 13. In: Lichtenstein L.M., Claman H., Oronsky A. and Schleimer R.P. (Eds) Antiinflammatory Steroid
Action: Basic and Clinical Aspects. Academic Press, NY p. 303-329.
81.
Kamilaris T., Chrousos G.P. (1989) Tests of Adrenal Function. In "Diagnostic Endocrinology" Eds W.T. Moore
and R. Eastman. B.C. Decker Inc. Toronto, CA. 79-109.
82.
Chrousos G.P., Laue L., Nieman L.K., Udelsman R., Kawai S., and Loriaux D.L. (1989) Clinical Applications of
RU 486, A Prototype Glucocorticoid and Progestin Antagonist. In: F. Mantero R. Takeda, B.A. Scoggins, E.G.
Biglieri and J. Funder (Eds) The Adrenal and Hypertension: From Cloning to Clinic. Serono Symposia Series,
Raven Press, NY p. 273-284.
83.
Chrousos G.P., Gold P.W. (1989) Clinical Implications of Corticotropin Releasing Hormone. F. Mantero and J.
Funder (Eds) The Adrenal Cortex: From Cloning to Clinic. Serono Symposia Series, Raven Press, NY p. 259-272.
84.
Smith M.A., Kling M.A., Whitfield H.J., Brandt H.A., Demitrack M.A., Geracioti T.D., Chrousos G.P., Gold P.W.
(1989) Corticotropin Releasing Hormone. From Endocrinology to Psychobiology. Horm. Res. 31: 66-71.
85.
Gold P.W., Altemus M, Goodwin F.K., Chrousos G.P. (1989) Brain-Mind Interactions. N. Engl. J. Med. (Letter to
the Editor) 320: 869-870.
86.
Kling M.A., Whitfield H.J., Brandt H.A., Demitrack M.A., Kalogeras K., Geracioti T.D., Perini G.I., Calabrese J.R.,
65
George P. Chrousos, M.D.
Chrousos G.P. and P.W. Gold (1989) Effects of Glucocorticoid Antagonism with RU 486 on Pituitary-adrenal
Function in Patients with Major Depression: Time-dependent Enhancement of Plasma ACTH Secretion.
Psychopharmacology Bull. 25: 466-472.
87.
Sternberg E.M., Wilder R.L., Chrousos G.P., Gold P.W., Young W.S., Bernardni R., Calogero A.E., Hill J.M.,
Kamilaris T., Listwak S.J. (1988) The Role of the Hypothalamic-pituitary-adrenal Axis in Susceptibility to
Arthritis. IN: Cushing's Syndrome and Other Hypercortisolemic States. Raven Press, New York. p. 183-188.
88.
Bernardini R., Rabin D., Margioris A., Grino M., Gold P.W., Chrousos G.P. (1989) The Hypothalamic-pituitaryadrenal Axis in Aging. In: Psychoneuroendocrinology of Aging. Fidia Research Series Vol. 16 Springer Verlag,
Padova, p. 75-81.
89.
Kling M.A., Perini G.I., Demitrack M.A., Geracioti T., Linnoila M., Chrousos G.P., Gold P.W. (1989) Stressresponsive Neurohormonal Systems and the Symptom Complex of Affective Disorder. Psychopharmacol. Bull. 25:
12-18.
90.
Chrousos G.P., Udelsman R., Margioris A., Gold P.W., Oldfield E.H., Schuermeyer T.H., Schulte H.M., Dopman J.,
Loriaux D.L. (1989) Corticotropin-releasing Factor. Physiological and Clinical Implications. In: E.E. Muller and
R.M. MacLeod (Eds). Neuroendocrine Perspectives. Vol 7, page 49-76 Elsevier Biomedical Press, New York.
91.
Cutler G.B. Jr., Schiebinger R.J., Albertson B.D., Cassorla G.B., Chrousos G.P., Comite F., Booth J.D., Levine J.,
Hobson W.C., Loriaux D.L. (1990) The Adrenarche (Human and Animal). In: "Second International Conference
on the Control of the Onset of Puberty", Eds M. Grumbach, P. Sizonenko, and M. Aubert. Williams and Wilkins,
Baltimore, p. 506-533.
92.
Loughlin T., Chrousos G.P. (1990) Hypoaldosteronism, In: Becker K.L. (Ed) Principles and Practice of
Endocrinology and Metabolism. J.B. Lippincott Co., New York. 643-649.
93.
Cassorla F., Chrousos G.P. (1990) The Adrenogenital Syndrome. In: Becker K.L. (ed.) Principles and Practice of
Endocrinology and Metabolism. J.B. Lippincott Co., New York. 604-613.
94.
Bernardini R., Calogero A.E., Gold P.W., Chrousos G.P. (1990) Mediators of the Immune Response. Relationships
with Hypothalamis Corticotropin Releasing Hormone and Pituitary Adrenal Corticotropin. In: Cushing's syndrome
and Other Hypercortisolemic States. Eds. D. Ludecke, G. Chrousos and G. Tolis. Raven Press, New York p. 15-20.
95.
Luger A., Deuster P., Chrousos G.P. (1990) Hypercortisolism of Exercise: In: Cushing's syndrome and Other
Hypercortisolemic States. Eds: D. Ludecke, G. Chrousos and G. Tolis, Raven Press, New York p. 77-82.
96.
Margioris A.N., Brockmann G., Gomez M.J., Chrousos G.P. (1990) Paracrine Effects of Placental Corticotropin
Releasing Hormone. In: Cushing's Syndrome and Other Hypercortisolemic States. Eds: D. Ludecke, G Chrousos
and G. Tolis, Raven Press, New York p. 189-192.
97.
Meyerhoff J.L., Oleshansky M.A., Kalogeras K.T., Mougey E.H., Chrousos G.P. and Granger L.G. (1990)
Neuroendocrine Responses to Emotional Stress: Possible Interactions Between Circulating Factors and Anterior
Pituitary Hormone Release. In Circulating Regulatory Factors and Neuroendocrine Function: Advances in
Experimental Biology and Medicine, ed. by J.C. Porter and D. Jezova, Plenum Press, 274: 91-111.
98.
Coutifaris C., Ringler G.E., Reed K., Margioris A., Chrousos G.P., Strauss J.F. III (1990) The Placenta and Stress:
Effects of Adenylate Cyclase Activators and of Glucocorticoids on the Endocrine Function of Trophoblastic Cells in
Culture. In: Neuroendocrine Regulation of Reproduction. Eds: S.S.C. Yen and W.W. Vale. Serono Symposia
USA, Norwell, Mass. p. 95-103.
99.
Chrousos G.P. (1990) Glucocorticoid Resistance. Birth Defects Encyclopedia. Alan R. Liss. Inc. New York. 784785.
100.
Margioris A.N., Chrousos G.P. (1990) Cushing's syndrome: Diagnostic Evaluation. In: Endocrine Hypertension.
E. Biglieri (editor), Raven Press, N.W. 99-111.
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George P. Chrousos, M.D.
101.
Sternberg E., Wilder R., Gold P.W., Chrousos G.P. (1990) A Defect in the Central Component of the Immune
System-hypothalamic-pituitary-adrenal Axis Feedback Loop is Associated with Susceptibility to Arthritis and
Inflammatory Disease. Ann. New York Acad. Sci. 594: 289-92.
102.
Susman E., Nottelman E., Dorn L., Gold P.W., Chrousos G.P. (1989) The Physiology of Stress andBehavioral
Development. In: Coping with Uncertainty: Biological, Behavioral and Developmental Perspectives. D.S.
Palermo and J. Kagan (Eds). Lawrence Erlbaum Assoc., Inc., Hillsdale, N.J., 17-38.
103.
Sternberg E.M., Wilder R.L., Chrousos G.P., Gold P.W. (1991) Stress Responses and the Pathogenesis of Arthritis.
In: Stress Neuropeptides, and Systemic Disease. Eds. J. A. McCubbin, P. Kaufman and C. Nemeroff, Academic
Press, 287-300.
104.
Hurley D., Chrousos G.P. (1991) Glucocorticoid Resistance. Current Therapy in Endocrinology and Metabolism.
W. Bardin (Ed.) B.C. Decker, Inc., Philadelphia, 150-151.
105.
Gomez M.T., Chrousos G.P. (1991) Cushing's Syndrome. Current Therapy in Endocrinology and Metabolism. W.
Bardin (Ed.) B.C. Decker, Inc., Philadelphia, 134-137.
106.
Kamilaris T., Chrousos G.P. (1991) Cushing's Syndrome in R-Rakel (Ed.) Conn's Current Therapy W.B. Saunders
Co., Philadelphia, 572-578.
107.
Gomez M.T., Chrousos G.P. (1991) Chronic Adrenal Insufficiency. In: Conn's Current Diagnosis. W.B. Saunders
Co., Philadelphia, 865-868.
108.
Laue L., Gold P.W., Richmond A., Chrousos G.P. (1991) The Hypothalamic-pituitary-adrenal Axis in Anorexia and
Bulimia Nervosa In: L.A. Barness (Ed.), Advances in Pediatrics 287-316.
109.
Flack M., Chrousos G.P. (1993) Neoplasms of the Adrenal Cortex In: Cancer Medicine, R. Holland et al. (Eds.)
Third Edition. Lea and Fibinger Inc., New York Vol 1, 1147-1153.
110.
Liapi C., Chrousos G.P. (1992) "Glucocorticoids". Chapter 41. In: Pediatric Pharmacology, S.J. Yaffe and J.V.
Aranda (Eds). 2nd Edition Saunders Publ Co. New York 466-475.
111.
Karalis K., Gold P.W., Chrousos G.P. (1992) Hypothalamic-pituitary-adrenal Function in Eating Disorders. In:
Psychiatry: A World Perspective Vol. 2 Neurosciences in Psychiatry. C. Stefanis, C. Soldatos, A. Rabavilas.
Excerpta Medica 537-544.
112.
Stratakis C., Karl M., Hurley D., Accili D., Vamvakopoulos N., Rorer E., Constantine K., Taylor S., Chrousos G.P.
(1991) A Point Mutation in the Hormone Binding Domain of the Glucocorticoid Receptor in Familial
Glucocorticoid Resistance. Horizons in Endocrinology. Eds., M. Maggi and V. Geenen, Serono Symposia Series,
Vol. 76:3-8.
113.
Nottelman E., Susman E., Chrousos G.P. (1990) Hormones and Adjustment in Puberty. In: Adolescence and
Puberty, J. Bancroft and J. Reinisch (Eds). Kinsey Institute Symposia Series 88-123.
114.
Rabin D., Chrousos, G.P. (1991) Adrenal Androgens In: Lerner R., Peterson A., and Brooks-Gunn J. Eds,
115.
The Encyclopedia of Adolescence. Garland Publ. New York. Vol. 1:53-55.
116.
Rabin D., Chrousos G.P. Gonadal Androgens. (1991) In: Lerner R., Petersen A and Brooks-Gunn J. Eds, The
Encyclopedia of Adolescence. Garland Publ. New York. Vol 1:56-59.
117.
Gold P.W., Kling M.A., Whitfield H.J., Demitrack M.A., Kalogeras K., Loriaux D.L., Chrousos G.P. (1988) The
Clinical Implications of Corticotropin Releasing Hormone. In: Progress in Endocrinology Imura H., Shizuma K,
Yoshida S. (Eds) Elsevier Science Publishers, Excerpta Medica New York 897-914.
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George P. Chrousos, M.D.
118.
Margioris A., Stratakis C., Chrousos G.P. (1991) Glucocorticoids and Other Adrenal Steroids. Chapter 35. In:
Human Pharmacology: Molecular to Clinical. L. Winegard, T. Brody, J. Larner and A. Schwartz (Eds). Mosby
Yearbook, St. Louis, p 484-493.
119.
Johnson E.O., Kamilaris T.C., Chrousos G.P., Gold P.W. (1992) Mechanisms of Stress: A Dynamic Overview of
Hormonal and Behavioral Homeostasis. J. Neurosc. Biobehav. Rev. 16:115-130.
120.
Perini G.I., Kling M.A., Calogero A.E., Devinski O., Smith M.A., Chrousos G.P., Gold P.W. (1990) Effects of
Carbamazepine on the Hypothalamic-pituitary-adrenal Axis: Potential Relevance of its Mechanisms of Action. In:
Canger R, Sacchetti E., Perini GI, Canevini MP, (Eds.) Carbamazepine: A Bridge between Epilepsy and Psychiatric
Disorders. Origgio: Ciba-Geigy Edizioni, 119-123.
121.
Chrousos G.P. (1993) Endocrine Tumors, In: Pizzo P.A., and Poplack D.G. (Eds). Principles and Practice of
Pediatric Oncology, J.B. Lippincott Co., New York, 2nd Edition 889-912.
122.
*Chrousos G.P., Gold P.W. (1992). The Concepts of Stress and Stress System Disorders: Overview of Physical and
Behavioral Homeostasis. JAMA 267:1244-1252.
123.
Chrousos G.P. (1992) Regulation and Dysregulation of the Hypothalamic-pituitary-adrenal Axis: The Corticotropin
Releasing Hormone Perspective. Endocrinology and Metabolism Clinics of North America 21:833-858.
124.
Chrousos G.P., Dorn L. (1993) Puberty, Adolescence, and the Stress Response. In: Frajese G., Steinberger E. and
Rodriguez R. (Eds) Reproductive Medicine. Serono Symposia Series, Raven Press, New York pp. 53-62.
125.
Karl M., Chrousos G.P. (1993) Familial Glucocorticoid Resistance: An overview. Exp. Clin. Endocrinol. 101:3035.
126.
*Sternberg E.M, Chrousos G.P., Wilder R.L., Gold P.W. (1992) The Stress Response and the Regulation of
Inflammatory Disease: NIH Combined Clinical Staff Conference. Ann. Int. Med. 117:854-866.
127.
Chrousos G.P., Karl M. (1992) The Molecular Mechanisms of Glucocorticoid Resistance. In: Saez J. (Ed) Cellular
and Molecular Biology of the Adrenal Cortex. John Libbey Eurotext Limited. London. Colloques INSERM
222:215-225.
128.
Sharara F.I., Chrousos G.P., Patronas N. (1992) Watchful Waiting and Craniopharyngioma. (Letter to the Editor)
Ann. Int. Med. 117:876-877.
129.
Mastorakos G., Webster E.L., Chrousos G.P. (1993) Corticotropin-releasing Hormone and Its Receptors in the
Ovary: Physiological Implications. Ann. New York Acad. Sci. 687:20-30.
130.
Dorn L.D., Chrousos G.P. (1993) The Endocrinology of Stress and Stress System Disorders in Adolescence. In: R.
Rosenfield (Editor) Adolescent Endocrinology. Endocrinology and Metabolism Clinics of North America 22:685700.
131.
Marini J.C., Bordenick S., Heavner G., Rose S.R., Chrousos G.P. (1993) Evaluation of the Growth Hormone Axis in
Osteogenesis Imperfecta. Am. J. Med. Genet. 45:261-264.
132.
Karl M., Chrousos G.P. (1995) Chapter 27, Molecular Aspects of Familial Glucocorticoid Resistance. In: B.
Weintraub (Editor) Molecular Endocrinology: Basic Concepts and Clinical Correlations. Raven Press, New York,
pp. 445-454.
133.
*Chrousos G.P., Detera-Wadleigh S., Karl M. (1993) NIH Conference of the Combined Clinical Staff: Syndromes
of Glucocorticoid Resistance. Ann. Int. Med., 119:1113-1124.
134.
Chicanza I.C., Chrousos G.P., Panayi G.S. (1992) Abnormal Neurendocrine-Immune Communications in Patients
with Rheumatoid Arthritis. Eur. J. Clin. Invest. 22:635-637.
68
George P. Chrousos, M.D.
135.
Zeiger M.A., Pass H.I., Doppman J.D., Nieman L.K., Chrousos G.P., Cutler G.B., Jensen R.T., Norton J.A. (1992)
Surgical Strategy in the Management of Non-Small Cell Ectopic Adrenocorticotropic Hormone Syndrome. Surgery
112:994-1000.
136.
*Boumpas D.T., Chrousos G.P., Wilder R.L., Cupps T.R., Balow J.E. (1993) NIH Conference of the Combined
Clinical Staff. Glucocorticoid Therapy of Immune-Related Diseases: Basic and Clinical Correlates. Ann. Inter.
Med. 119:1198-1208.
137.
*Vamvakopoulos N.C., Chrousos G.P. (1994) Hormonal Regulation of Human Corticotropin Releasing Hormone
Gene Expression. Implications for the Stress Response and Immune/Inflammatory Reaction. Endocrine Reviews,
15:409-420.
138.
Karl M., Accili A., Chrousos G.P. (1993) Familial Glucocorticoid Resistance and Its Molecular Basis. In: New
Perspectives in Endocrinology, Serono Symposia, A. Debellis and K.B. Marschke eds., Raven Press, New York,
Vol. 99, pp. 83-91.
139.
Karl M., Schulte H.M., Chrousos G.P. (1994) Mutation Analysis of Steroid Hormone Receptors. In Neurobiology
of Steroids, deKloet E.R. and W. Suntanto eds., Vol. of Methods in Neurosciences, Academic Press 22:226-241.
140.
Friedman T.C., Chrousos G.P. (1993) Transsphenoidal Resection in Cushing's Disease: Definition of Success.
(Letter to the Editor) Clinical Endocrinology, 39:701.
141.
*Chrousos G.P. (1995) The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation. New
England Journal of Medicine 332:1351-1362.
142.
Margioris A., Gravanis A., Chrousos G.P. (1994) Glucocorticoids and Mineralocorticoids. Chapter 35. In: Human
Pharmacology: Molecular to Clinical. T. Brody, J. Larner, K. Minneman, H.C. Neu (Eds) Mosby-Yearbook, St.
Louis p. 473-481.
143.
Magiakou M.A., Chrousos G.P. (1994) Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid
Withdrawal. Current Therapy in Endocrinology and Metabolism. Mosby-Year Book Inc., St. Louis p.120-124.
144.
Arai K., Chrousos G.P., (1994) Glucocorticoid Resistance. Chapter 5, Baillere's Clinical Endocrinology and
Metabolism. Vol. 8, No.2. Baillere Tindal London p. 317-331.
145.
Arai K., Chrousos G.P., (1995) Syndromes of Glucocorticoid and Mineralocorticoid Resistance. Steroids 60:173179.
146.
Magiakou M.A., Chrousos G.P., (1996) Glucocorticoid Therapy and Withdrawal. Chapter 6 In: R.C.Bone.
Current Practice of Medicine. Current Medicine, Inc., Philadelphia, IV 6.1-6.6.
147.
Bamberger C.M., Chrousos G.P., (1994) Glucocorticoid Resistance. (Letter to the Editor) Annals of Internal
Medicine 102:1047-1048.
148.
Stratakis C.A., Mastorakos G., Chrousos G.P. (1994) Interleukin-6 Elevation in Critically Ill Infants with Sepsis and
Necrotizing Enterocolitis. (Letter to the Editor) J Pediatrics 125:504.
149.
Tsigos C., Chrousos G.P. (1994) Physiology of the Hypothalamic-Pituitary-Adrenal Axis in Health and
Dysregulation in Psychiatric and Autoimmune Disorders. Endocrin. Metab. Clin. N. Amer. 23:451-466.
150.
Chrousos G.P. (1996) Chapter 1. Organization and Integration of the Endocrine System.
Endocrinology, Sperling M., ed., Saunders Co.: Philadelphia, 1-14.
151.
Magiakou M.A., Chrousos G.P. (1994) Diagnosis and Treatment of Cushing's Disease. In: The Pituitary Gland, H.
Imura (ed), 2nd Edition, Raven Press: New York, p. 491-508.
152.
Mastorakos G., Chrousos G.P (1995) Chapter 79, Adrenal Hyperandrogenism. In: Reproductive
In: Pediatric
69
George P. Chrousos, M.D.
153.
Endocrinology, Surgery, and Technology. Adashi E., Rock J., and Rosenwaks Z. eds. Raven Press, New
1539-1553.
York, p.
154.
Stratakis C.A., Karl M., Schulte H.M., Chrousos G.P. (1994) Glucocorticoid Resistance in Humans. Elucidation of
the Molecular Mechanisms and Implications for Pathophysiology. Ann N.Y. Acad Sci 746:362-376.
155.
Tsigos C., Chrousos G.P. (1995) Stress, Endocrine Manifestations and Diseases. Chapter 3. In: Handbook of Stress
Medicine. Cooper C.L., ed. Boca Raton, FL: CRC Press Inc., 61-65.
156.
Stratakis C.A., Gold P.W., Chrousos G.P. (1995) Neuroendocrinology of Stress: Implications for Growth and
Development. Hormone Research 43:163-167.
157.
Tsigos C., Chrousos G.P. (1995) Clinical Presentation, Diagnosis, and Treatment of Cushing's Syndrome. Current
Opinion in Endocrinology and Diabetes, 2:203-213.
158.
Papanicolaou D., Chrousos G.P. (1995) Interactions of the Endocrine and Immune Systems in Children and Young
Adults. Current Opinion in Pediatrics, 7:440-444.
159.
Karl M., Chrousos G.P. (1996) Experimental and Clinical Models of CRH-Induced Pituitary Tumors. In:
Oncogenesis and Molecular Biology of Pituitary Tumors. S. Melmed (ed) Front. Horm. Res. Vol. 20 Karger, Basel,
54-71.
160.
Tsigos C., Papanicolaou D., Chrousos G.P. (1995) Advances in the Diagnosis and Treatment of Cushing's
Syndrome. Bailliere's Clinical Endocrinology and Metabolism 9:315-336.
161.
Tsigos C., Arai K., Latronico A.C., Webster E., Chrousos G.P. (1995) Receptors for Melanocortin Peptides in the
Hypothalamic-Pituitary-Adrenal Axis and Skin. Ann. NY Acad. Sci. 771:352-363.
162.
Tsigos C., Chrousos G.P. (1995) The Neuroendocrinology of the Stress Response. Chapter 6. In: NIDA Alcohol
Research Monograph: Stress, Gender, and Alcohol Seeking Behavior. W.A. Hunt and S. Zachari, ed., CSR, Inc.,
Washington, D.C., 29:103-124.
163.
Tsigos C., Chrousos G.P. (1996) The Neuroendocrinology of Stress. In: Women, Health and Disability. D.
Krotowski, M. Nosek, M. Turk (eds), Brookes Publishers, Baltimore, 203-221
164.
Flack MR, Chrousos G.P. (1996) Neoplasms of the Adrenal Cortex. Chapter 101. Cancer Medicine, 4th Edition.
R. Holland et al. (eds) Lea and Fibinger, New York, 1563-1570.
165.
Peeke P.M., Chrousos G.P. (1995) Hypercortisolism and Obesity. Ann. NY Acad. Sci. 771:665-676.
166.
Stratakis C.A., Chrousos G.P. (1995) Neuroendocrinology of Stress and the Immune Response. In: Root A., ed.
Proceedings of the 1994 NCGS Investigators Meeting. Gardiner-Caldwell, Califon, NJ, p. 4-7.
167.
Stratakis C.A., Vamvakopoulos NC, Chrousos G.P. (1995) Corticotropin-Releasing Hormone, Stress and
Depression. In: Bailly D., ed. Neuroendocrine Aspects of Mood Disorders. Ardix Médical, Levallois p. 119-152
(in french).
168.
Stratakis C.A., Chrousos, G.P. (1997) Endocrine Tumors. In: Pizzo P.A., Poplack D.G., eds. Principles and
Practice of Pediatric Oncology, 3rd edition. J.B. Lippincott Raven Publishers, Philadelphia, p. 947-976.
169.
Tsigos C., Kamilaris T., Chrousos G.P. (1996) Adrenal Diseases. In: Moore W.T., Eastman R., eds. Diagnostic
Endocrinology, 2nd edition. B.C. Decker Inc., Toronto, p. 123-156.
170.
Tsigos C., Chrousos G.P. (1996) Differential Diagnosis and Management of Cushing's Syndrome. Ann Rev Med
47:443-61
171.
Chrousos, G.P. (1995) Cytokine Therapy in Septic Shock. (Letter to the Editor) N. Engl. J. Med., 333:942-943.
70
George P. Chrousos, M.D.
172.
Bamberger C.M., Chrousos G.P. (1995) The Glucocorticoid Receptor and RU 486 in man. Ann. N.Y. Acad. Sci.
761;296-311.
173.
Bamberger C.M., Bamberger A.M., Chrousos G.P. (1995) Dominant Negative Inhibitors of the Glucocorticoid
Receptor. In: De Bellis A., Schipani E. (eds.) Frontiers in Endocrinology, Vol. 14. Serono Symposia Publication,
Rome, Italy, pp. 129-139.
174.
Stratakis C.A., Chrousos G.P. (1995) Neuroendocrinology and Pathophysiology of the Stress System. Ann. N.Y.
Acad. Sci. 771:1-18.
175.
Cizza G., Gold P.W., Chrousos G.P. (1995) Aging is Associated in the 344/N Fischer Rat with Decreased Stress
Responsivity of Central and Peripheral Catecholaminergic Systems and Impairment of the Hypothalamic-PituitaryAdrenal Axis. Ann. N.Y. Acad. Sci. 771:491-511.
176.
Crofford L.J., Sano H., Karalis K., Webster E.A., Friedman T.C., Chrousos G.P., Wilder R.L. (1995) Local
Expression of Corticotropin-Releasing Hormone in Inflammatory Arthritis. Ann. N.Y. Acad. Sci. 771:459-471.
177.
Mastorakos G., Magiakou M.A., Chrousos G.P. (1995) Effects of the Immune/Inflammatory Reaction on the
Hypothalamic-Pituitary-Adrenal Axis. Ann. N.Y. Acad. Sci. 771:438-448.
178.
Carter C.S., DeVries A.C., Taymans S.E., Roberts R.L., Williams J.R., Chrousos G.P. (1995) Adrenal Corticoid
Hormones and the Development and Expression of Mammalian Monogamy. Ann. N.Y. Acad. Sci. 771:82-91.
179.
Reincke M., Lehmann R., Karl M., Magiakou M.A., Chrousos G.P., Allolio B.
Neuroendocrinology. Ann. N.Y. Acad. Sci. 771:556-569.
180.
*Latronico A.C., Chrousos G.P. (1997) Adrenocortical Tumors (Extensive Personal Experience Article). J. Clin.
Endocrinol. Metab. 82:1317-1324.
181.
Gold P.W., Licinio J., Wong M.L., Chrousos G.P. (1995) Corticotropin Releasing Hormone in the Pathophysiology
of Melancholic and Atypical Depression and in the Mechanism of Action of Antidepressant Drugs. Ann. N.Y.
Acad. Sci. 771:716-729.
182.
Marini J.C., Bordenick S., Chrousos G.P. (1995) Endocrine Aspects of Growth Deficiency in OI. Connective Tissue
Research 31:S55-S57.
183.
Masi A, Chrousos G.P. (1996) The Hypothalamic-Pituitary-Adrenal-Glucocorticoid Axis in Rheumatoid Arthritis.
(Editorial) J. Rheumatol. 23:577-581.
184.
Chrousos G.P., Castro M., Leung D.Y.M., Webster E., Kino T., Bamberger C., Elliot S., Stratakis C., Karl M.
(1996) Molecular Mechanisms of Glucocorticoid Resistance/Hypersensitivity. Am. J. Resp. Crit. Care Med.
154:S39-S44.
185.
*Bamberger C.M., Schulte H.M., Chrousos G.P.. (1996) Molecular Determinants of Glucocorticoid Receptor
Function and Tissue Sensitivity. Endo. Rev. 17:221-244.
186.
Torpy D.J., Chrousos G.P. (1996) The Three-Way Interactions Between the Hypothalamic-Pituitary- Adrenal and
Gonadal Axes and the Immune System. Ballière's Clinical Rheumatology 10:181-198.
187.
Masi A.T., Chrousos G.P. (1997) Dilemmas of Low-Dosage Glucocorticoid Therapy in Rheumatoid Arthritis:
Considerations of Timing. (Leader) Annals of Rheumatic Diseases 56:1-4.
188.
Cizza G., Gold P.W., Chrousos G.P. (1997) High-Dose Transdermal Estrogen, Corticotropin- Releasing Hormone
and Postnatal Depression (Letter to the Editor). J. Clin. Endocrinol. Metab. 82:704.
189.
Cizza G., Chrousos G.P. (1997) Anxiety and Short Stature (Letter to Editor). Pediatrics 99:500.
(1995) Severe Illness.
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George P. Chrousos, M.D.
190.
Gold P.W., Wong M-L, Chrousos G.P., Licinio J. (1996) Stress System Abnormalities in Melancholic and Atypical
Depression: Molecular, Pathophysiological, and Therapeutic Implications (Editorial). Mol. Psychiatry 1:257-264.
191.
Cizza G., Chrousos G.P. (1997) Adrenocorticotropic Hormone-Dependent Cushing's Syndrome: Chapter 2.
Endocrine Neoplasms, Andrew Arnold, Ed. Klawer Academic Publishers, Boston, pp. 25-40.
192.
Latronico A.C., Chrousos G.P. (1997) Neoplasms of the Adrenal Cortex. Chapter 11. In: Endocrine Neoplasms,
Andrew Arnold, Ed., Klawer Academic Publishers, Boston, pp. 217-237.
193.
Torpy D., Papanicolaou D., Chrousos G.P. (1997) Sexual Dimorphism of the Human Stress Response May Be Due
to Estradiol-mediated Stimulation of Hypothalamic Corticotropin-Releasing Hormone Synthesis. (Letter to the
Editor) J. Clin. Endocrinol. Metab. 82:982.
194.
Dorn L., Chrousos G.P. (1997) The Neurobiology of Stress: Understanding Regulation of Affect During Female
Biological Transitions. Seminars in Reproductive Medicine 15:29-45.
195.
Stratakis C.A., Chrousos G.P. (1997) The Familial Lentiginosis Syndromes: Link to Inherited Neoplasias and
Identification of a Genetic locus. Hellenic Medical Journal 1:15-19.
196.
Chrousos G.P. (1997) The Neuroendocrinology of Stress: Its Relation to the Hormonal Milieu, Growth, and
Development. Growth, Genetics & Hormones 13:1-8.
197.
Stratakis C.A., Chrousos G.P. (1997) Chapter 13. Hypothalamic Hormones: GnRH, TRH, GHRH, SRIF, CRH, and
Dopamine. Endocrinology: Basic and Clinical Principles, Conn P.M. and Melmed S. (Eds.), Humana Press,
Totowa, NJ. 185-209.
198.
Magiakou M.A., Chrousos G.P. (1997) Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid
Withdrawal. Current Therapy in Endocrinology and Metabolism, Sixth Edition, Bardin C.W. (Editor), Mosby, St.
Louis, MO 138-142
199.
De Castro M., Chrousos G.P. (1997) Glucocorticoid Resistance. Current Therapy in Endocrinology and
Metabolism, Sixth Edition, Bardin C.W. (Editor), Mosby, St. Louis, MO 188-189.
200.
Torpy D.J., Chrousos G.P. (1997) General Adaptation Syndrome: An Overview.
Disease, Ober K.P. (Editor), Human Press, Totowa, NJ 1-24.
201.
Chrousos G.P. (1997) The Future of Pediatric and Adolescent Endocrinology. Ann. New York Acad. Sci., 816:4-8.
202.
Mastorakos G., Ghizzoni L., Webster E.L., Chrousos G.P. (1997) Autocrine-Paracrine Role of Ovarian
Corticotropin-Releasing Hormone. Ann. New York Acad. Sci., 816:22-26.
203.
Magiakou M.A., Mastorakos G., Webster E., Chrousos G.P. (1997) The Hypothalamic-Pituitary- Adrenal Axis and
the Female Reproductive System. Ann. New York Acad. Sci., 816: 27-41.
204.
Magiakou M.A., Mastorakos G., Chrousos G.P. (1997) Cushing Syndrome: Differential Diagnosis and Treatment.
Wierman M.E. (Editor), Diseases of the Pituitary: Diagnosis and Treatment, Humana Press, Totowa, NJ 179-202.
205.
*Clauw D.J., Chrousos G.P.
(1997) Chronic Pain and Fatigue Syndromes: Overlapping Clinical and
Neuroendocrine Features and Potential Pathogenic Mechanisms. NeuroImmunoModulation 4:134-153.
206.
*Papanicolaou D.A., Wilder R.L., Manolagas S.C., Chrousos G.P.
Interleukin-6 in Humans. Ann. Intern. Med. 128:127-137.
207.
Chrousos G.P. (1997) Adrenal Hyperandrogenism. In: Up-to-date in Endocrinology and Diabetes (CD ROM).
Editor-in-Chief, Burton D. Rose. Endocrine Society, Bethesda, MD.
Endocrinology of Critical
(1998) The Pathophysiologic Roles of
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George P. Chrousos, M.D.
208.
Licinio J., Gold P.W., Chrousos G.P., Sternberg E.M. (1997) Forty Years of Neuroendocrinology (Editorial). Mol.
Psychiatry 2:347-349.
209.
Webster E.L., Elenkov I.J., Chrousos G.P.
(1997) The Role of Corticotropin-Releasing Hormone in
Neuroendocrine-Immune Interactions. Mol. Psychiatry 2:368-372.
210.
Chrousos G.P. (1997) Stress as a Medical and Scientific Idea and Its Implications. Advances in Pharmacology
42:552-556.
211.
Chrousos G.P. (1997) Secondary Adrenal Insufficiency. In: The Diagnosis and Treatment of Pituitary
Insufficiency, S.W.J. Lamberts (Editor), Bioscientifica, Bristol, UK 39-61.
212.
Pillemer S.R., Bradley L.A., Crofford L.J., Moldofsky H., Chrousos G.P.
Endocrinology of Fibromyalgia. Arthritis & Rheumatism 40:1928-1939.
213.
Stratakis C.A., Chrousos G.P. (1997) The Case of Urinary Growth Hormone (Editorial). Endocrine Practice 3:389391.
214.
*Torpy D.J., Chrousos G.P. (1997) Stress and Critical Illness: the Integrated Immune/Hypothalamic- PituitaryAdrenal Axis Response. J. Intensive Care Med. 12:225-238.
215.
*Chrousos G.P. (1998) Ultradian, Circadian and Stress-Related Hypothalamic-Pituitary-Adrenal Axis Activity: A
Dynamic Digital-to-Analog Modulation (Editorial). Endocrinology 139:437-440.
216.
*Chrousos G.P., Torpy D., Gold P.W. (1998) Interactions Between the Hypothalamic-Pituitary- Adrenal Axis and
the Female Reproductive System:Clinical Implications. Ann. Intern. Med. 129:229-240.
217.
Bornstein S.R., Torpy D.J., Chrousos G.P., Licinio J., Engelmann L. (1997) Leptin Levels are Elevated Despite
Low Thyroid Hormone Levels in the “Euthyroid Sick” Syndrome (Letter to the Editor). J. Clin. Endocrinol. Metab.
82:4278-4279.
218.
Chrousos G.P. (1998) Stressors, Stress and Neuroendocrine Integration of the Adaptive Response: 1997 Hans Selye
Memorial Lecture. Ann. NY Acad. Sci. 851:311-335.
219.
Shupnik M.A., Chrousos G.P., Siragy H.M. (1997) Glucocorticoids and Mineralocorticoids. In: Human
Pharmacology: Molecular to Clinical, Third Edition, T.M. Brody, J. Larner, K.P. Minneman (Eds), Mosby-Year
Book, St. Louis, MO 485-497.
220.
Tsigos C., Chrousos G.P. (1998) ACTH Resistance Syndromes. In: G Proteins, Receptors, and Disease. A.M.
Spiegel (Ed), Humana Press, Totowa, NJ 261-269.
221.
Stratakis C.A., Chrousos G.P. (1998) Cushing Syndrome and Cushing Disease. In: Saunders Manual of Pediatric
Practice. L. Finberg (Ed), W.B. Saunders Company, Philadelphia, PA 807-809.
222.
*Chrousos G.P., Gold P.W. (1998) A Healthy Body in a Healthy Mind- and Vice Versa-: The Damaging Power of
“Uncontrollable” Stress (Editorial). J. Clin. Endocrinol. Metab. 83:1842-1845.
223.
Chrousos G.P., Stratakis C.A. (1998) Carney Complex and the Familial Lentiginosis Syndromes: Link to Inherited
Neoplasias and Developmental Disorders, and Genetic Loci. J. Intern. Med. 243:573-579.
224.
Meduri G.V., Chrousos G.P. (1998) Duration of Glucocorticoid Treatment and Outcome in Sepsis: Is the Right
Drug Used the Wrong Way? (Editorial). Chest . 114:355-360.
225.
*Torpy D.J., Bornstein S.R., Cizza G., Chrousos G.P. (1998) The Effects of Glucocorticoids on Leptin Levels in
Humans May Be Restricted to Acute Pharmacologic Dosing. (Letter to the Editor) J. Clin. Endocrinol. Metab.
83:1821-1822.
(1997) The Neuroscience and
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George P. Chrousos, M.D.
226.
Webster E.L., Torpy D.J., Elenkov I.J., Chrousos G.P. (1998) Corticotropin-Releasing Hormone and Inflammation.
Ann. NY Acad. Sci. 840:21-32.
227.
Leung D.Y.M., De Castro M., Szefler S.J., Chrousos G.P. (1998) Mechanisms of Glucocorticoid- Resistant Asthma.
Ann. NY Acad. Sci. 840:735-746.
228.
Reincke M., Arlt M., Heppner C.A., Petzke F., Chrousos G.P., Allolio B. (1998) Neuroendocrine Dysfunction in
African Trypanosomiasis. Ann. NY Acad. Sci. 840:809-821.
229.
*Chrousos G.P., Harris A.G. (1998) Hypothalamic-Pituitary-Adrenal Axis Suppression and Inhaled Corticosteroid
Therapy. Part I. General Principles. Neuroimmunodulation 5:277-287.
230.
*Chrousos G.P., Harris A.G., (1998) Hypothalamic-pituitary-adrenal Axis Suppression and Inhaled Corticosteroid
Therapy. Part II. Review of the Literature. Neuroimmunodulation 5:288-308.
231.
Orban Z., Bornstein S.R., Chrousos G.P. (1998) The Interaction Between Leptin and the Hypothalamic-PituitaryThyroid Axis. Horm. Metab. Res. 30:231-235.
232.
Stratakis C.A., Chrousos G.P. (1998) Adrenal Diseases. In: Principles of Molecular Medicine, L. Jameson (Ed.),
Humana Press. Totowa, NJ., p. 495-503.
233.
Chrousos G.P. (1998) Neuroendocrine Alterations Associated with Altered Sleep, Mood, and Pain Perception. In:
The Neuroscience and Endocrinology of Fibromyalgia, S. R. Pillemer (ed.), The Haworth Press, Inc., Binghampton,
NY, p. 51-55 and. J. Musculoskeletal Pain 6:51-55, 1998.
234.
Diamanti-Kandarakis E., Chrousos G.P. (1998) Cushing’s Syndrome and Androgen Excess. In: Androgen Excess
Disorders in Women. R. Azziz, J.E. Nestler, D. Dewailly (eds). Lippincott-Raven Publishers, Philadelphia, p.569584.
235.
Margioris A., Chrousos G.P. (1998) Adrenal Disorders. In: Handbook of Clinical Neurology. Part II. Systemic
Diseases. Vinten P.J., Bruyn G.W. (Eds.) Elsevier Science 26:205-220
236.
*Gold PW, Chrousos G.P. (1999) The Endocrinology of Melancholic and Atypical Depression:
Neurocircuitry and Somatic Consequences. Proc. Assn. Amer. Phys., 111:22-34
237.
*Bornstein S.R., Chrousos G.P. (1999) Adrenocorticotropin ACTH- and Non-ACTH-Mediated Regulation of the
Adrenal Cortex: Neural and Immune Inputs. J. Clin. Endo. Metab., 84:1729-1736.
238.
Chrousos G.P. (2000)The Role of Stress and the Hypothalamic-Pituitary-Adrenal Axis in the Pathogenesis of the
Metabolic Syndrome: Neuro-Endocrine and Target Tissue-related Causes (Review). Intern. J. Obesity, 24:S50-S55
239.
Tsigos, C., Kyrou I, Papanicolaou D., Chrousos G.P. (1998) Prolonged Suppression of Corticosteroid- binding
Globulin by Recombinant Human Interleukin-6 in Man. [Letter to the Editor]. J. Clin. Endo. Metab 83:3379.
240.
Masi A.T., Chrousos G.P., Bornstein S.R. (1999) Enigmas of Adrenal Androgen and Glucocorticoid Dissociation in
Premenopausal Onset Rheumatoid Arthritis. [Editorial] J. Rheumatology. 26:247-250.
241.
Torpy, D.J., Stratakis, C.A., Chrousos G.P. (1999) Hyper- and Hypoaldosteronism. Vit. Horm. 57:177-216.
242.
Mastorakos G., Bamberger C., Chrousos G.P. (1999) Neuroendocrine Regulation of the Immune Process. In:
Plotnikoff N.P., Faith R.F., Murgo A.J., Good R.A., (Eds) Cytokines, Stress and Immunity. CRC Press Boca Raton,
Fla., p.17-37.
243.
*Bornstein S.R., Stratakis C.A., Chrousos G.P. (1999) Adrenocortical Tumors: Recent Advances in Basic Concepts
and Clinical Management. Ann. Intern. Med. 130:759-771.
244.
*Merke D.P., Bornstein S.R., Braddock D., Chrousos, G.P. (1999) Adrenal Lymphocytic Infiltration and
Relation to
74
George P. Chrousos, M.D.
Adrenocortical Tumors in a Patient with 21-Hydroxylase Deficiency. (Letter to the Editor) N. Engl. J. Med.
340:1121-1122.
245.
Franchimont, D.P., Chrousos, G.P. (1999) Glucocorticoid Resistance and Hypersensitivity. Contemporary
Endocrinology: Hormone Resistance Syndromes. (Ed. L. Jameson) Humana Press, Totowa N.J., p.259-271
246.
Chrousos, G.P. (1999) Reproductive/placental corticotropin-releasing hormone and its clinical implications, Am. J.
Obstetrics Gynecol. p.S249-S250.
247.
Papanicolaou D., Chrousos, G. P. Cushing’s Syndrome (1999) Rakel’s Current Therapy. Editor Robert E. Rakel. W.
B. Saunders Co., Philadelphia p.631-637.
248.
Chrousos, G. P. , Gold, P.W. (1999) The Inhibited Child “Syndrome”. Thoughts on Its Potential Pathogenesis and
Sequelae. In: Extreme Fear, Shyness and Social Phobia: Origins, Biological Mechanisms, and Clinical Outcomes,
(eds.) L. A. Schmidt, J. Schulkin, Oxford Univ. Press, New York p.193-200
249.
Koch, C.A., Bornstein, S.R., Pacak, K, Chrousos, G.P. (1998) How does metyrapone decrease seizures? (Letter to
the Editor) Neurosurg. Rev. 21:302-303.
250.
Chrousos, G. P. (1999) Glucocorticoid Therapy and Withdrawal, Current Practice of Medicine, 1:291- 296
251.
*Elenkov, I.J., Chrousos, G.P. (1999) Stress Hormones, Th1/Th2-patterns, Pro/Anti- Inflammatory Cytokines and
Susceptibility to Disease. Trends Endo Metab., 10:359-368
252.
*Vottero, A., Chrousos, G.P. (1999) Glucocorticoid Receptor Beta: View I. Trends Endo Metab., 10:333-338
253.
Elenkov, I. J., Webster, E. L., Torpy, D. J., Chrousos, G.P. (1999) Stress, Corticotropin-Releasing Hormone,
Glucocorticoids, and the Immune/Inflammatory Response: Acute and Chronic Effects. Annals NY Academy of
Sciences, 876:1-13.
254.
Chrousos, G.P., Elenkov, I. (2001) Interactions of the Endocrine and Immune Systems, in DeGroot L., Jameson L.
(eds.) Endocrinology 4th Edition, W. B. Saunders Co., Philadelphia, Vol 1, p.571-586.
255.
*Bornstein, S. R., Bottner, A., Chrousos, G.P., (1999) Editorial, Knocking Out the Stress Response. Mol Psychiatry
4 (5) :403-407.
256.
Elenkov, I., Wilder, R., Chrousos, G.P., Visi, E. S., (2000) The Sympathetic Nervous System - an Integrative
Interface Between Two “Supersystems”: The Brain and the Immune System, Pharmacol. Rev., 52: 595-638
257.
*Lafferty, A. R., Chrousos, G.P., (1999) Pituitary Tumors in Children and Adolescents, J. Clin. Endocrinol. Metab.,
84:4317-4323.
258.
*Chrousos, G.P., (1999) Editorial, A New “New” Syndrome in the New World: Is Multiple Postreceptor Steroid
Hormone Resistance Due to a Coregulator Defect?, J. Clin. Endocrinol. Metab., 84:4450-4453.
259.
Kalantaridou S.N., Chrousos G.P. (2000) Molecular Defects Causing Ovarian Dysfunction, Ann. N.Y. Acad. of Sci.
Vol. 900, 40-45.
260.
Funasaka, Y., Sato, H., Chakraborty, A. K., Ohashi, A., Chrousos, G.P., Ichihashi, M., (1999) Expression
Proopiomelanocortin, Corticotropin-Releasing Hormone (CRH), and CRH Receptor in Melanoma Cells, Nevus
Cells, and Normal Human Melanocytes, J. Investigative Dermatology 4:105-109
261.
Meyer S.E., Chrousos G. P., Gold P.W. (2001) Major Depression and the Stress System, Development and
Psychopathology 13:565-580
262.
*Koch, C. A., Doppman, J. L., Patronas, N. J., Nieman, L. K., Chrousos, G.P. (2000) Do Glucocorticoids Cause
Spinal Epidural Lipomatosis? – When Endocrinology and Spinal Surgery Meet. Endo. Rev., 11:86- 90.
75
George P. Chrousos, M.D.
263.
Chrousos G.P., (2000) Dehydroepiandrosterone and its Sulfate, Electronic Up-Date in Endocrinology, Endocrine
Society, US.
264.
Negrao, A.B., Deuster, P.A., Gold, P.W., Singh, A., Chrousos, G.P. (2000) Individual Reactivity and Physiology of
the Stress Response. Biomed & Pharmacother 54:122-128.263.
265.
Chrousos G. P., (2000) The Stress Response and Immune Function: Clinical Implications, The 1999 Novera H.
Spector Lecture. Ann. New York Acad. Sci., 917:38-67.
266.
Vottero A., Chrousos G.P., (1999) Glucocorticoid Receptor Isoforms Alpha and Beta: Potential Physiological and
Pathological Importance, The J. of Endocrine Genetics 1: 61-71.
267.
Stratakis C.A., Chrousos G.P., (1999) Adrenal Cancer, Endocrinology and Metabolism Clinics of North America,
29:15-25.
268.
Elenkov, I.J. and Chrousos, G.P. (1999) Stress, cytokine patterns and susceptibility to disease. Stress and Immunity:
the Neuroendocrine Link, Baillière’s Clinical Endocrinology and Metabolism 13(4): 583-595.
269.
Willenberg H.S., Bornstein S.R., Chrousos G.P., (2000) Disease, Stress-Induced, Overview, Encyclopedia of Stress,
Vol. 1, Academic Press, San Diego, 1:709-713.
270.
Willenberg H.S., Bornstein S.R., Chrousos G.P., (2000) Adrenal Insufficiency, Encyclopedia of Stress, Academic
Press, San Diego, 1:58-63.
271.
Bornstein S.R., Stratakis C.A., Chrousos G.P. (2000) Cushing’s Syndrome, Medical Aspects, Encyclopedia of
Stress, Vol. 1, Academic Press San Diego, 1: 615-621.
272.
Koch C.A., Bornstein S.R., Chrousos G.P., Stratakis C.A. (2000) Primare pigmentierte nodulare adrenokortikale
Dysplasie (PPNAD) in Rahmen des Carney-Komplexes als Ursache eines Cushing-Syndroms. Medizinische Klinik,
95:224-230.
273.
Creatsas G., Mastorakos G., Chrousos G. P. (2000) Introduction: Setting Reproductive Health Priorities to Meet the
Needs of the New Millennium. Ann. N.Y. Acad. Sci. 900:viii-xv.
274.
Vgontzas A.N., Papanicolaou D.A., Chrousos G. P. (2000) Chronic Systemic Inflammation in Overweight and
Obese Adults. (Letter to the editor) JAMA 283(17):2235-2236.
275.
Chrousos G.P. and Margioris A.N.. (2000) Adrenocorticosteroids and Adrenocortical Antagonists. Ed. B. Katzung,
Basic and Clinical Pharmacology, Lange, McGraw-Hill, New York, New York. 39:660-678.
276.
Chrousos G.P., Zoumakis E., Gravanis A. (2000) The Gonadal Hormones and Inhibitors. Ed. B. Katzung, Lange,
McGraw-Hill, New York, New York. 40:679-710.
277.
Pacak, K., Chrousos, G.P., Koch, C.A., Lenders, J.W.M., Eisenhofer, G (2001). “Pheochromocytoma: Progress in
Diagnosis, Therapy, and Genetics” in Margioris, A.N. and Chrousos, G.P. (Eds.) Adrenal Disorders, Humana Press:
New Jersey, p. 379-414
278.
*Leung, D.Y.M., Chrousos, G.P. (2000) Is there a role for glucocorticoid receptor-beta in glucocorticoid-dependent
asthmatics? (Editorial) Am J Respir Crit Care Med 162:1-3.
279.
Bornstein, S.R., Chrousos, G.P. (2001) Chapter 229.The Hypothalamic-Pituitary-Adrenal Axis in Stress and Critical
Illness. Principles and Practice of Endocrinology and Metabolism, K. Becker (Ed.) 3 rd Edition, Lippincott Williams
& Wilkins Philadelphia, Pa p. 2087-2094
280.
Kino, T., Vottero, A., Chrousos, G.P. (2001) “Mineralocorticoid and Glucocorticoid Receptors” in Burris, T.P. and
McCabe, E.R.B. (Eds.) Nuclear Receptors and Genetic Disease, Academic Press: San Diego, p. 297-307.
76
George P. Chrousos, M.D.
281.
*Chrousos, G.P. (2001) Adrenal Suppression and Clinical Glucocorticoid Deficiency in the Premature Infant: No
Simple Answers (Clinical Perspective). J Clin Endocrinol Metab.86: 473-474
282.
Miller, W., and Chrousos, G.P.(2001) Chapter 11: The Adrenal Cortex. Endocrinology and Metabolism, Felig P.,
and Frohman L. Eds., 4th Edition, McGraw-Hill, New York, NY. p387-524
283.
Chrousos, G.P. (2001) Chapter 14: Glucocorticoid Therapy. Endocrinology and Metabolism, Felig P. and Frohman
L., Eds. 4th Edition, McGraw-Hill, New York, NY, p 609-632
284.
Chrousos G. P. (2000) Stress, Chronic Inflammation, and Emotional and Physical Well-being: Concurrent Effects
and Chronic Sequelae. J. Allergy Clin. Immunol., 106: S275-S291.
285.
Elenkov, I.J., Chrousos, G.P., Wilder, R.L. (2000) Neuroendocrine Regulation of IL-12 and TNF-(/IL-10 Balance.
Ann. N.Y. Acad. Sciences, 917:94-105.
286.
Koch, C.A., Huang, S.C., Vortmeyer, A.O., Zhuang Z., Chrousos, G.P., Pacak, K. (2000) A patient with MEN 2 and
multiple mutations of RET in the germline (Letter to the editor). Experimental and Clinical Endocrinology and
Diabetes, 108:493.
287.
Torpy, D., Stratakis, C.A., Chrousos, G.P. (2000) Familial Hyperaldosteronism. Braz. J. Med. Biol. Res., 33:11491155.
288.
Chikanza, I.C., Petrou, P., Chrousos, G.P. (2000) Perturbations of Arginine Vasopressin Secretion during
Inflammatory Stress. Ann. New York Acad. Sci., 917:825-834.
289.
*Merke, D.P., Bornstein S. R., Avila N. and Chrousos G.P. (2002) Future Directions in the Study and Management
of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. Ann. Internal Med. 136:320-334
290.
Cizza G., Ayala A., Daley M., Gold P.W., Chrousos G.P. (2001) Depression and Osteoporosis: Association or
Causal Relationship? In: Physical Consequences of Depression, Ed. J. H. Thakore, Wrightson Biomedical
Publishing LTD, Philadelphia, Penn 107-24.
291.
*Kino T., Chrousos G.P. (2001) Glucocorticoid and Mineralocorticoid Resistance/Hypersensitivity Syndromes. J.
Endocrinol. 169:437-445
292.
Chrousos G. P., Kino T. (2002) Corticosteroid (Glucocorticoid) Receptor. Encyclopedia of Molecular Medicine, T.
Creighton, Editor, John Wiley and Son, New York, N.Y. 916-919
293.
Vottero A. and Chrousos G.P. (2004) Glucocorticoid Resistance and States. In Encyclopedia of Endocrine Diseases.
Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 235-241
294.
*Meyer S.E., Chrousos G.P., Gold P.W. (2001) Major Depression and the Stress System: A Lifespan Perspective.
Development and Psychopathology 13: 563-578
295.
*Cizza, G., Ravn, P., Chrousos, G.P., Gold, P.W. (2001) Depression: a major, unrecognized risk factor for
osteoporosis? Trends Endocrinol Metab. 12(5): 198-203.
296.
*Mitsiades, N., Poulaki, V., Mitsiades, C.S., Koutras, D.A., Chrousos, G.P. (2001) Apoptosis induced by FASL and
TRAIL/APO2L in the pathogenesis of thyroid disease. Trends in Endocrinol. Metabolism 12:384-390
297.
Bornstein S. and Chrousos, G.P., (Guest Eds. ). (2001) Adrenals. Reviews in Endocrine and Metabolic Disorders 3;
Issue 3.
298.
Magiakou M.A., and Chrousos G.P. (2002) Cushing Syndrome in Children and Adolescents: Current Diagnostic and
Therapeutic Strategies. J. Endocrinol. Invest. 25: 181-194
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George P. Chrousos, M.D.
299.
McGriff N.,J., Csako G., Kabbani M., Diep L., Chrousos G.P. , Pucino F. (2001) Treatment Options for a Patient
Experiencing Pruritic Rush Associated with Transdermal Testosterone. A Review of the Literature.
Pharmacotherapy 21:1425-35
300.
Joint LWPES/ESPE CAH Working Group. (2002) Consensus Statement on 21-Hydroxylase Deficiency. J. Clin.
Endocrinol. Metab. 87: 4048-4053
301.
Chrousos G. P., Ghizzoni L. and New M.I. (Guest Eds.) (2001) Endocrine Diseases: From Childhood to Adulthood.
Special Issue: J. Endocrinol. Invest. 24 Issue 9
302.
Habib K., Gold P. W., and Chrousos G.P. (2001) Neuroendocrinology of Stress. Endocrinol. Metab. Clin. NA 30:
695-728
303.
*Kino T., and
Chrousos G. P. (2001) Editorial. AIDS-related Insulin Resistance and Lipodystrophy: A
Multifactorial Viral and Iatrogenic Condition. Endocrine Practice. 7: 479-484
304.
*Koch C., and Chrousos G. P. (2001) Editorial. Is the Diminuto/Dwarf1 Gene Involved in Physiologic
Adrenocortical Size Regulation and Tumor Formation? J. Clin. Endocrinol. Metab. 86: 5127-9
305.
Carter C. S., Altemus M., Chrousos G.P. (2001) Neuroendocrine and Emotional Changes in the Post-partum Period.
Progr. Brain Res. 133: 241-249
306.
Chrousos G.P., Lafferty A., (2001) Glucocorticoid Therapy and Cushing Syndrome. eMedicine Journal 2(9)
307.
Chrousos G.P., Lafferty A., (2001) Nelson Syndrome. eMedicine Journal 2(9)
308.
Chrousos G.P., Lafferty A., (2001) Hyperaldosteronism. eMedicine Journal 2(9)
309.
Radebold K., Koch C. A., Chrousos G.P., (2001) Multiple Endocrine Neoplasias. eMedicine Journal 2(9)
310.
Koch CA, Pacak K, Chrousos GP. (2002) Chapter 37. Endocrine Tumors. In: Pizzo PA, Poplack DG (eds):
Principles and Practice of Pediatric Oncology; 4th edition, Lippincott Williams & Wilkins; Philadelphia, PA;p 11151148
311.
Koch CA, Chrousos GP. (2003) Diagnosis and Management of Cushing's Disease. In: Powell M, Lightman SL,
Laws ER (eds.): Management of Pituitary Tumors: The Clinician's Practical Guide. Humana Press, Totowa, NJ; p
51-76
312.
Koch CA, Huang SC, Vortmeyer AO, Chrousos GP, Pacak K, Zhuang Z. (2001) Do somatic RET mutations
represent a phenomenon of tumor progression ? Curr Opin Clin Exp Res 3(3):140-145
313.
*Gold PW, Chrousos GP (2002) Organization of the Stress System and Its Dysregulation in Melancholic and
Atypical Depression: High vs. Low CRH/NE States. Mol. Psychiatry 7: 254-275
314.
*Kino T. and Chousos GP, (2002) Editorial. Tissue-specific Glucocorticoid Resistance/Hypersensitivity Syndromes:
Multifactorial States of Clinical Importance. J. Allergy Clin. Immunol. 109: 609-613
315.
*Koch C. A, Chrousos GP, Chandra R, Evangelista R S, Gilbert JC, Nobuhara K, Zhuang Z, Vortmeyer AO (2002)
Two-hit Model for Tumorigenesis of Nevoid Basal Cell Carcinoma (Gorlin) Syndrome-associated Hepatic
Mesenchymal Tumor. Am. J. Med Genetics 109: 74-76
316.
Vgontzas AN, Vela-Bueno A, Chrousos GP (2002) Chapter 50. Endocrine Disorders and Sleep. In:
Medicine, Lee-Chiong TL, Sateia MJ, Carscadon MA (Eds.) Hanley and Belfus, Inc. Philadelphia p 477-487
317.
Habib K, Gold PW, Chrousos G (2002) Hypothalamic-pituitary-adrenal Axis: Introduction to Physiology and
Pathophysiology. Hormones, Brain and Behavior. 4: 841-866
Sleep
78
George P. Chrousos, M.D.
318.
*Vgontzas A., Chrousos GP (2002) Editorial. Sleep Disordered Breathing, Sleepiness, and Insulin Resistance: Is the
Latter a Consequence, a Pathogenetic Factor or Both? Sleep Medicine 3: 389-391
319.
* Kalantaridou S, Chrousos GP (2002) Clinical Review 148. Monogenic Disorders of Puberty. J. Clin. Endocrinol.
Metab. 87: 2481-2494
320.
Chrousos GP (2002) Chapter 264. Cushing Syndrome and Cushing Disease.In: L. Finberg and R Kleinman, Eds.
Saunders Manual of Pediatric Practice 2nd Edition, WB Saunders Co.Philadelphia p909-911
321.
Chrousos GP and Linder B (2002) Chapter 278. Steroid Withdrawal. In: L. Finberg and R Kleinman, Eds. Saunders
Manual of Pediatric Practice 2nd Edition, WB Saunders Co. Philadelphia p950-952
322.
*Tsigos C and Chrousos GP (2002) Hypothalamic-pituitary-adrenal Axis, Neuroendocrine Factors and Stress.
Psychosomatic Research 53: 865-871
323.
Gold PW, Gabry KE, Yasuda MR, Chrousos GP (2002) Divergent Endocrine Abnormalities in Melancholic and
Atypical Depression: Clinical and Pathophysiologic Implications. Endocrinol. Metab. Clin. North America 31:37-62
324.
Vgontzas AN, Chrousos GP (2002) Sleep, the Hypothalamic-pituitary-adrenal Axis, and Cytokines: Multiple
Interactions and Disturbances in Sleep Disorders. Endocrinol. Metab. Clin. North America 31: 15-36
325.
Koska J, Ksinantova L, Sebokova E, Kvetnansky R, Klimes I, Chrousos G, Pacak K (2002) Endocrine Regulation of
Subcutaneous Fat Metabolism during Cold Exposure in Humans. Ann. NY Acad Sci 967: 500-505
326.
Chrousos G.P. (2002) Chapter 1. Organization and Integration of the Endocrine System.
Endocrinology, Sperling M., ed., Saunders Co.: Philadelphia, 1-14.
327.
Elenkov IJ, Chrousos GP (2002) Stress Hormones, Proinflammatory and Antiinflammatory Cytokines and
Autoimmunity. Ann. N Y Acad Sci 966: 290-303.
328.
*Grammatopoulos D., Chrousos GP (2002) Structural and Signalling Diversity of Corticotropin-releasing Hormone
(CRH) and Related Peptides and Their Receptors: Potential Clinical Applications of CRH Receptor Antagonists.
Trends in Endocrinol. Metab. 13: 436-444
329.
Kino T., Vottero A., Charmandari E., and Chrousos GP (2002) Familial/Sporadic Glucocorticoid Resistance
Syndrome and Hypertension. Ann. NY Acad Sci. 970: 101-111
330.
Alesci S., Chrousos GP, Pacak K. (2002) Genomic Medicine: Exploring the Basis of a New Approach to Endocrine
Hypertension. Ann. NY Acad. Sci 970: 177-192
331.
Working Group, Lawson Wilkins Pediatric Endocrine Society and European Society for Pediatric Endocrinology
(2002) Consensus Statement on Congenital Adrenal Hyperplasia. J. Clin. Endocrinol. Metab. 87: 4042-4047
332.
Vottero A and Chrousos GP (2002) Glucocorticoid Resistance and Hypersensitivity Syndromes. Oxford Textbook
of Endocrinology and Diabetes, Eds. J. Wass and S. Shalet Oxford University Press, Oxford, p. 845-851
333.
Chrousos GP (2002) The Neuroendocrinology of Stress. Clinical Endocrinology (Japan) 51:13-14
334.
*Franchimont D, Kino T, Galon J, Meduri GU, Chrousos GP (2003) Glucocorticoids and Inflammation Revisited.
NIH Clinical Staff Conference. NeuroImmunoModulation 10:247-260
335.
*Koch C, Pacak K, Chrousos GP (2002) The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical
and Adrenomedullary Tumors. J Clin Endocrinol Metab, 87: 5367-5384
336.
Vgontzas A, Chrousos GP (2003) Hypothalamic-pituitary-adrenal Axis and Sleep. Chapter 31. www.Endotext.com
337.
*Charmandari E, Kino T, Souvatzoglou E and Chrousos GP (2003) Pediatric Stress: Hormonal Mediators and
In: Pediatric
79
George P. Chrousos, M.D.
Human Development. Hormone Res., 59: 161-179
338.
*Gerrity TR, Bates J, Bell DS, Chrousos G, Furst G, Hedrick T, Hurwitz B, Kula RW, Levine SM, Moore RC,
Schondorf R (2002) Chronic Fatigue Syndrome: What Role Does the Autonomic System Play in the
Pathophysiology of this Complex Illness? NeuroImmunoModulation 10:134-141
339.
Makrigiannakis A, Zoumakis E, Kalandaridou S, Mitsiadis N, Margioris N, Chrousos G and Gravanis A (2002)
Corticotropin-releasing Hormone (CRH) and Immunotolerance of the Fetus. Bioch. Pharmacol. 7507: 917-921
340.
Chrousos GP (2002) New Editor-in-Chief’s Note. NeuroImmunoModulation 10: 129-131
341.
Kino T. and Chrousos GP (2002) The Hypothalamic-pituitary-adrenal Axis in AIDS. www.endotext.com
342.
*Masi A and Chrousos GP (2003) Editorial: Polycystic Ovarian Syndrome and Rheumatoid Arthritis: Possible Clues
to Hormonal Influences on Chronic Inflammation. Sem Arthritis and Rheumatism 33:67-71
343.
Magiakou MA and Chrousos GP (2002) Glucocorticoid Therapy and Adrenal Suppression. www.endotext.com
344.
Latronico AC and Chrousos GP (2002) Adrenal Cancer. Diagnosis and Treatment. www.endotext.com
345.
Arai K, Shibasaki T, Chrousos GP (2002) Aldosterone Deficiency and Resistance. www.endotext.com
346.
*Kino T, Mirani M, Alesci S, Chrousos GP (2003) AIDS-related Lipodystrophy/Insulin Resistance Syndrome.
Horm. Metab. Res. 35: 129-136
347.
*Wolak M, Chrousos GP and Gold PW (2003) Stress System: Emphasis on Corticotropin-releasing Factor in
Physiologic Stress Responses and the Endocrinopathies of Melancholic and Atypical Depression. Endocrine Rev., in
Press
348.
Vottero A, Chrousos GP (2003) Glucocorticoid Resistance Syndromes and States. Chapter 16. www.Endotext.com
349.
Kino T and Chrousos GP (2003) AIDS-related Insulin Resistance and Lipodystrophy Syndrome. Current Drug
Targets- Immune, Endocrine and Metabolic Disorders 3: 111-117
350.
*Hochberg Z., Pacak K., Chrousos GP (2003) Endocrine Withdrawal Syndromes. Endocrine Rev. 24: 523-548
351.
Koch C, Chrousos GP (2003) Chapter 4. Cushing Disease, In: Management of Pituitary Tumors: The Clinician’s
Practical Guide. Eds M P Powell, SL Lightman and Laws ER Humana Press, Totowa NJ, 51-75
352.
Charmandari E, and Chrousos GP (2003) Adrenal Insufficiency. www.endotext.com
353.
Gourgiotis L and Chrousos GP (2003) Pseudo-Cushing States. www.endotext.com
354.
Charmandari E, Kino T and Chrousos GP (2003) Glucocorticoids. Neonatal and Pediatric Pharmacology. Second
Edition. Ed. S. Yaffe. Lippincott Williams and Wilkins, Philadelphia, Penn. p 713 (14)
355.
Pedrone E, Goldman R, Calis K, Chrousos GP, Cizza G (2003) Glucocorticoid-induced Osteoporosis.
www.endotext.com
356.
Vgontzas A. Bixler EO, Chrousos GP (2003) Metabolic Disturbances in Obesity vs. Sleep Apnea: The
of Visceral Obesity and Insulin Resistance. J Intern Med. 254: 32-4
357.
Arnaldi G, Angeli A, Atkinson A, Bertagna X, Cavagnini F, G. Chrousos, G. Fava A, Findling J, Gaillard RC,
Grossman AB, Kola A, Lacroix A, Mancini T, Mantero F, Newell-Price J,. Nieman LK, Sonino N,. Vance ML,
Giustina A and M. Boscaro (2003) Diagnosis And Complications of Cushing’s Syndrome: A Consensus Statement
Journal of Clinical Endocrinology and Metabolism 88: 5593-602
Importance
80
George P. Chrousos, M.D.
358.
Charmandari E. Kino T. and Chrousos GP (2004) Glucocorticoid Resistance Syndrome. eMedicine.com
359.
Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A (2003) Uterine and Embryonic
Trophoblast CRH Promotes Implantation and Maintenance of Early Pregnancy. Ann NY Acad Sci. 997: 85-92
360.
Kalantaridou SN, Makrigiannakis A, Mastorakos G, Chrousos GP (2003) Roles of Reproductive Corticotropinreleasing Hormone. Ann NY Acad Sci, 997: 129-135
361.
Kalantaridou SN, Makrigiannakis A, Zoumakis E and Chrousos GP (2004) Reproductive Functions of
Corticotropin-releasing Hormone (CRH). Research and Potential Clinical Utility of Antalarmins (CRH Receptor
Type 1 Antagonists) J. Reprod Immunol 51(4): 269-74.
362.
Chrousos G.P. (2004) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Ed. B. Katzung, Basic
and Clinical Pharmacology, Lange, McGraw-Hill, New York, New York. 641-660
363.
Chrousos G.P., (2004) Chapter 40. The Gonadal Hormones and Inhibitors. Ed. B. Katzung, Lange, McGraw-Hill,
New York, New York 661-692
364.
Kino T., Charmandari E. and Chrousos GP (2003) Glucocorticoid Receptor. www.Endotext .com
365.
Kino T., De Martino MU, Charmandari E., Mirani M, and Chrousos GP (2003) Tissue Glucocorticoid Resistance/
Hypersensitivity Syndromes. J Ster Biochem Mol Biol 85:457-467.
366.
Kino T, Charmandari E, and Chrousos GP (2003) Basic and Clinical Implications of Glucocorticoid Actions.
Proceedings of a Conference Dedicated to Professor Yukitaka Miyachi. Horm and Metabol Res.,35: 628-638 pr
367.
Kino T, and Chrousos GP (2004) Chapter 14. Glucocorticoid and Mineralocorticoid Receptors and Associated
Diseases. Essays in Biochemistry, Vol 40 : The Nuclear Receptor Superfamily. 40:137-55.
368.
Baker DG, Geracioti TD, Kasckow JW, Zoumakis E, Chrousos GP (2003) Chapter 14. Cytokines and Post-traumatic
Stress Disorder. In: Cytokines and Mental Health, Ed. Z. Kronfol, Kluwer Academic Publishers, Boston.301-338.
369.
Charmandari E., Kino T., Chrousos G.P. Glucocorticoid Receptor.In Encyclopedia of Endocrine Diseases. Luciano
Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA
370.
Charmandari E., Chrousos G.P. Glucocorticoids, Overview. In Encyclopedia of Endocrine Diseases. Luciano
Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA
371.
Charmandari E., Chrousos G.P. Adrenal Insufficiency. In Encyclopedia of Endocrine Diseases. Luciano Martini
(ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 75-80
372.
Chrousos G.P. Stress and Endocrine Physiology. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed),
Elsevier, Academic Press, 2004, San Diego, CA, USA
373.
Ayala A and Chrousos GP. (2004) Hypercortisolism and Cushing Syndrome. In Encyclopedia of Endocrine
Diseases. Luciano Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA 540-548
374.
Grimaldi L and Chrousos GP Metabolic and Endocrine Disorders. In Nichols D, Yaster M, Lappe DG, Haller JA
and Paidas C (eds.) Golden Hour: The Handbook of Advanced Pediatric Life Support. Mosby Pub. Philadelphia (in
press).
375.
Kanaka-Gantenbein C, Mastorakos G and Chrousos GP (2003) Endocrine –related Causes and Consequences of
Intrauterine Growth Retardation. Ann NY Acad Sci 997: 150-157
376.
Chrousos G, Charmandari E, and Kino T (2004) Editorial. Networks of Glucocorticoid Actions: An Introduction to
Systems Biology. J Clin Endocrinol Metab, 89: 563-564
81
George P. Chrousos, M.D.
377.
Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A (2004) Participation of Maternal and Fetal
CRH in Early Phases of Human Implantation: The Role of Antalarmin. Curr Drug Targets- Imm Endo and Metab
Dis 4:75-78
378.
Charmandari E, Kino T and Chrousos GP (2004) Familial/Sporadic Glucocorticoid Resistance. Orphanet
Encyclopedia www.orpha.net
379.
Charmandari E, Kino T and Chrousos GP (2004) Glucocorticoid Actions. Orphanet Encyclopedia www.orpha.net
380.
Contoreggi C, Rice KC, Chrousos GP (2004) Non-peptide Corticotropin-releasing Hormone Receptor Type 1
Antagonists and their Applications in Psychosomatic Disorders. Neuroendocrinology 80:111-123
381.
Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP (2004) Reproductive Functions of Corticotropinreleasing Hormone. Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists) Am
J Reprod Immunol 51: 269-274
382.
Chrousos G (2004) Editorial. The Glucocorticoid Receptor Gene, Longevity, and the Highly Prevalent Complex
Disorders of Western Societies. Am J Medicine 117: 204-207
383.
Chrousos GP (2004) Editorial. Is 11-beta- Hydroxysteroid Dehydrogenase Type 1 a Good Therapeutic Target for
Blockade of Glucocorticoid Actions? Proc Ntl Acad Sci USA, 101: 6329-30
384.
Magiakou MA, Chrousos G.P. Adrenal Suppression. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed),
Elsevier, Academic Press, 2004, San Diego, CA, USA 81-89
385.
Koch C, Chrousos G.P. Adrenal Tumors: Molecular Pathogenesis. In: Encyclopedia of Endocrine Diseases. Luciano
Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 90-98
386.
Charmandari E, Kino T, Chrousos G.P. Glucocorticoid Receptor. In Encyclopedia of Endocrine Diseases. Luciano
Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 229-234
387.
Charmandari E, Chrousos G.P. Glucocorticoids, Overview. In Encyclopedia of Endocrine Diseases. Luciano Martini
(ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 253-259
388.
Alesci S, Su YA, Chrousos GP (2004) hMiDas and hMitChip (2004) New Opportunities in Mitochondrial
Bioinformatics and Genomic Medicine. Eds. Long R., Antani S., Lee DJ, Nutter B, Zhang M. Proc 17 IEEE
Computer-based Medical Systems, Los Alamitos, Ca p329-334
389.
Tsigos C, Kyrou I and Chrousos GP (2004) Stress, Endocrine Physiology and Pathophysiology. www.Endotext.com
390.
Chrousos GP (2004) Book Review. Male Hypogonadism, by Winters SG, Ed Totowa, NJ: Humana Press. Annals of
Intern Medicine 140: 1064
391.
Chrousos GP (2004) Book Review. Microcompetition with Foreign DNA and the Origin of Chronic Disease, by
Polansky H, Ed. Center for Biology of Chronic Disease, Rochester. Neuroimmunomodulation 11: 278
392.
Charmandari E, Kino T., Chrousos G. (2004) Glucocorticoids and their actions: an introduction. Ann N Y Acad
Sci. 1024:1-8.
393.
Charmandari E, Kino T., Chrousos G. (2004) Familial/sporadic glucocorticoid resistance: clinical phenotype and
molecular mechanisms. Ann N Y Acad Sci. 1024:168-81.
394.
Kino T, Chrousos G. (2004) Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the
AIDS-related insulin resistance/lipodystrophy syndrome? Ann N Y Acad Sci. 1024:153-67.
395.
DeMartino MU, Alesci S, Chrousos GP (2004) Interaction of the glucocorticoid receptor and the chicken ovalbumin
upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose,
82
George P. Chrousos, M.D.
lipoprotein, and xenobiotic metabolism. Ann N Y Acad Sci. 1024:72-85.
396.
Kino T and Chrousos GP (2004) Glucocorticoid and mineralocorticoid receptors and associated diseases. Essays
Biochem. 40:137-155.
397.
*Vgontzas AN, Bixler EO, Lin H-M, Prolo P, Trakada G, Chrousos G (2005) Interleukin-6 and Its Circadian
Secretion in Humans. Neuroimmunomodulation 2005;12(3):131-140
398.
Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2004) Stress and the female reproductive system.
J Reprod Immunol. 62:61-8.
399.
Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G. (2004) Endometrial and placental CRH as
regulators of human embryo implantation. J Reprod Immunol. 62:53-9.
400.
*Kanaka-Gantenbein C, Fryssira H, Chrousos G, Mastorakos G (2004) Growth hormone deficiency in a case of
cerebrofaciothoracic syndrome in one of two affected siblings. Am J Med Genet;129A:330.
401.
Costello RB and Chrousos GP (2005) Other Bioactive Food Components and Dietary Supplements. Report to the
Institute of Medicine, Natl Acad Sci US, pp 462.
402.
Charmandari E, Kino T, Chrousos GP (2004) Chapter 49. Glucocorticoids,.In: Neonatal and Pediatric
Pharmacology: Therapeutic Principles in Practice. Eds. Yaffe S and Aranda J. Lippincott, Williams and Wilkins
Co,Philadelphia Pa 713-726
403.
Weiss LM, Bertagna X, Chrousos GP et al. (2004) Adrenal Cortical Carcinoma, In: Tumors of Endocrine Origin,
Pathology and Genetics, WHO Organization and Classification of Tumors, Eds. DeLellis, Lloyd RV and Heitz PU
and Eng C IARC Press, Lyon 139-142
404.
Sasano H, Young WF, Jr,, Chrousos GP et al. (2004) Adrenal Cortical Adenoma , In: Tumors of Endocrine Origin,
Pathology and Genetics, WHO Organization and Classification of Tumors, Eds. DeLellis, Lloyd RV and Heitz PU
and Eng C IARC Press, Lyon 143-146
405.
*Linos D, Kiriakopoulos AC, Tsakayannis DE, Theodoridou M, Chrousos G .(2004) Laparoscopic excision of
bilateral primary adrenal leiomyosarcomas in a 14-year-old girl with acquired immunodeficiency syndrome (AIDS),
Surgery 136(5):1098-100.
406.
Tsigos C., Kyrou I, Chrousos G.P. (2005) Stress, Endocrine Manifestations and Diseases. Chapter 6. In: Handbook
of Stress Medicine and Health. Second Edition, Cooper C.L., ed. Boca Raton, FL: CRC Press Inc., 109-129.
407.
Vgontzas AN, Bixler EO and Chrousos GP (2005) Sleep Apnea Is A Manifestation of the Metabolic Syndrome.
Sleep Medicine Reviews. 9(3):211-24.
408.
*Charmandari E, Chrousos GP, Merke D (2005) Adrenocorticotropin Hypersecretion and Pituitary Microadenoma
Following Bilateral Adrenalectomy in a Patient with Classic 21-Hydroxylase Deficiency. J Pediatr. Endocrinol.
18(1):97-101.
409.
*Charmandari E, Tsigos C, Chrousos GP (2005) Neuroendocrinology of Stress. Ann Rev Physiol. Vol. 67: 259284
410.
*Chrousos G, Kino T (2005) Ikaros Trancription Factors: Flying between Stress and Inflammation. J Clin Invest.
115:844-848
411.
*Alesci S, De Martino MU, Ilias I, Gold PW, Chrousos GP. (2005) Glucocorticoid-induced osteoporosis: from basic
mechanisms to clinical aspects. Neuroimmunomodulation 12(1):1-19.
412.
Ayala A, Chrousos G (2005) Cushing’s Syndrome. In: Adrenal Glands: Diagnostic Aspects and Surgical Therapy.
Eds. D. Linos and J. van Heerden. Springer-Verlag, Berlin, New York p57-66
83
George P. Chrousos, M.D.
413.
Charmandari E, Chrousos G and Merke D(2005) Classic Congenital Adrenal Hyperplasia. In: Adrenal Glands:
Diagnostic Aspects and Surgical Therapy. Eds. D. Linos and J. van Heerden. Springer-Verlag, Berlin, New York
p101-114
414.
Chrousos GP and Makrigiannakis A (2005) Guest Editors. 39 th Annual Meeting of the European Society of Clinical
Investigation. Eur J Clin Invest 35 (Suppl 2): 1-94
415.
Kino T and Chrousos G (2005) Glucocorticoid Effects on Gene Expression. In: Handbook on Stress and the Brain.
Vol 15. Eds. Stechler T, Kalin NH and Reul JMHM. p 295- 311
416.
Vgontzas AN, Pejovic S and Chrousos GP (2005) Endocrine and Metabolic Disorders and Sleep. Encyclopedia of
Sleep Medicine, Ed. Teofilo Lee-Chiong. John Wiley&Sons, Inc.
417.
Siragy HM, Chrousos GP and Shupnik MA (2005) Chapter 33. Glucocorticoids and Mineralocorticoids.In: Brody’s
Clinical Pharmacology. Molecular to Clinical. 4th Edition. Eds: KP Minneman, L Wecker. Elsevier-Mosby p 409421
418.
*Chrousos GP and Kino T (2005) Interactive Functional Specificity of the Stress and Immune Responses: The Ying,
the Yang and the Defense Against Two Major Classes of Bacteria. J Infectious Dis. 192: 551-555
419.
Vgontzas AN, Bixler EO, Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev.
2005 Jun; 9(3):211-24.
420.
Magiakou MA, and Chrousos GP (2005) Chapter 4.Biological Basis of Stress-related Diseases. In: Research
Companion to Organizational Health Psychology. Eds. AS Antoniou and CL Cooper. EE Publishing, Cheltenham
UK p70-86
421.
*Papadimitriou A, and Chrousos GP (2005) Reconsidering the Sex Diffrences in the Incidence of Pubertal
Disorders. Horm Metab Res 37:708-710
422.
Chrousos GP and Kino T (2005) Glucocorticoid Action Networks and Systemic Complex Diseases. In: Hormones,
Age and Cancer. Berstein L (ed) Nauka Publ Co. St. Petersburg p.226-236
423.
Stratakis C and Chrousos GP (2005) Hypothalamic Hormones, In: Endocrinology: Basic and Clinical Principles,
Second Edition, Eds. S Melmed and PM Conn. Humana Press, Totowa NJ , p.173-195
424.
*Meduri GU and Chrousos GP (2006) Effectiveness of Prolonged Glucocorticoid Treatment in ARDS: The Right
Drug the Right Way? Crit Care Med. 34(1):236-238
425.
*Chrousos GP and Kino T (2005) Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns
Stochastic. Perspective, Science: Signal Transduction Knowledge Environment (STKE). 304: pe48
426.
*Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP (2005) Cytokine Dysregulation, Inflammation and Wellbeing. Neuroimmunomodulation 12:255-269
427.
*Chrousos G P, Kaltsas G (2005) How Accurate Are Currently Used Methods of Determining Glycemia in
Critically Ill Patients and Do They Affect Their Clinical Course? Crit Care Med. 33:2849-51
428.
*Chrousos GP, Kaltsas G. (2005) Post-SARS Sickness Syndrome Manifestations and Endocrinopathy: how, why,
and so what? Clin Endocrinol (Oxf). 63(4):363-5.
429.
*Macrigiannakis A, Kalantaridou S, Minas V, Nikas G, Chrousos GP (2006) Hormonal and Cytokine Regulation of
Early Implantation. Trends Endocrinol Metab. 17(3):101-9
430.
*Kalantaridou SN, Naka KK, Bechlioulis A, Makrigiannakis A, Michalis L and Chrousos GP (2006) Premature
Ovarian Failure, Endothelial Dysfunction and Estrogen/Progestogen Replacement. Trends Endocrinol Metab.
84
George P. Chrousos, M.D.
17(5):178-85.
431.
*Kalantaridou SN, Makrigiannakis A, Zoumakis E and Chrousos GP (2007) Peripheral Corticotropin-releasing
Hormone Is Produced in the Immune and Reproductive Systems: Actions, Potential Roles and Clinical Implications.
Front Bioscience 12:572-80
432.
*Pervanidou P, Kanaka-Gantenbein C and Chrousos GP (2006) Assessment of Metabolic Profile in a Clinical
Setting. Curr Opinion in Clinical Nutrition and Metabolic Care 9(5):589-595
433.
Zoumakis E, Grammatopoulos D and Chrousos G (2006) Corticotropin-releasing Hormone Antagonists. Eur J
Endocrinol 155 (Suppl1) S85-S90
434.
Chrousos GP and Kaltsas GA (2006) Chapter 16. The Stress System and the Hypothalamic-pituitary-adrenal Axis in
Rheumatoid Arthritis. In: Rheumatoid Arthritis, 2 nd edition, Firestein GS, Panayi GS, and Wollstein FA. Oxford
University Press p221-228
435.
Magiakou MA, Smyrnaki P, Chrousos GP. (2006) Hypertension in Cushing's syndrome. Best Pract Res Clin
Endocrinol Metab. 20:467-82
436.
Kino T, Chrousos GP (2005) Steroid Hormone Receptor Defects, Molecular Basis.Encyclopedic Reference of
Genomics and Proteomics. Springer-Verlag p 1802-1807 On line www.springerlink.com
437.
*Giannoulia-Karantana A, Vlachou A, Polychronopoulou S, Papassotiriou I, Chrousos GP. (2006) Melatonin and
Immunomodulation: Connections and Potential Clinical Applications: Neuroimmunomodulation. Nov 21; 13(3):6374
438.
Charmandari E and Chrousos GP (2006) Metabolic Syndrome Manifestations in Classic Congenital Adrenal
Hyperplasia: Do they Predispose to Cardiovascular Atherosclerotic Disease and Secondary Polycystic Ovary
Syndrome? Ann NYAcad Sci 1083: 37-53
439.
*Kalantaridou S, Makrigiannakis A, Zoumakis E, Chrousos GP. (2007) Peripheral Corticotropin-releasing Hormone
Is Produced in the Immune and Reproductive Systems: Actions, Potential roles and Clinical Implications. Front
Biosci. 12:572-80.
440.
*Kanaka-Gantenbein C, Fryssira H, Kakavakis K, Bouzas E, Thomaidis L, Chrousos G, Mastorakos G. (2006) Two
years of growth hormone treatment in the first growth hormone deficient patient with cerebrofaciothoracic dysplasia.
J Pediatr Endocrinol Metab. 19:1179-83.
441.
*Chrousos GP (2007) Commentary: Is laparoscopic adrenalectomy good for all adrenal masses? Nature Clinical
Practice: Endocrinology and Metabolism 3: 210-211
442.
Vgontzas AN, Bixler EO, Chrousos GP. (2006) Obesity-related sleepiness and fatigue: the role of the stress system
and cytokines. Ann N Y Acad Sci. 1083:329-44.
443.
Zoumakis E, Rice KC, Gold PW, Chrousos GP. (2006) Potential uses of corticotropin-releasing hormone
antagonists. Ann N Y Acad Sci.1083: 239-51.
444.
Kyrou I, Chrousos GP, Tsigos C. (2006) Stress, visceral obesity, and metabolic complications. Ann N Y Acad
Sci.1083: 77-110.
445.
*Kino T and Chrousos GP (2007) Virus-mediated Modulation of the Host Endocrine Signaling Systems: Clinical
Implications. Trends Endocrinol Metab. 18: 159-166
446.
Creatsas G, Mastorakos, Chrousos GP (2006) Foreword: Women's Health: The World's Safeguard. Ann NY Acad
Sci 1092: xiii–xv.
447.
Elenkov IJ, Chrousos GP. (2006) Stress system - organization, physiology and immunoregulation.
85
George P. Chrousos, M.D.
Neuroimmunomodulation. 2006; 13 (5-6):257-67. Epub 2007
448.
Kaltsas G and Chrousos GP (2007) The Neuroendocrinology of Stress. In: Handbook of Psychophysiology Eds.
Cacioppo J, Tassinary, and Berntson GG, Cambridge University Press, Cambridge p 303-318
449.
*Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM and Chrousos GP (2007) Mitochondria as Critical
Components of the Stress Response. Trends Endocrinol. Metab. 18(5):190-8
450.
*Kanaka-Gantenbein C, Papandreou E, Stefanaki K, Fryssira H, Kolialexi A, Sophocleous C, Mavrou A, KitsiouTzeli S, Chrousos GP. (2007) Spontaneous Ovulation in a True Hermaphrodite with Normal Male Phenotype and a
Rare 46,XX/47,XXY Klinefelter's Mosaic Karyotype. Horm Res 26; 68 (3):139-144
451.
Willenberg HS, S. R. Bornstein and Chrousos G. P. (2007) Adrenal Insufficiency, In: Encyclopedia of Stress, 2nd
Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 47-52
452.
Pervanidou P and Chrousos G. P. (2007) Brain Natriuretic Peptide (BNP), In: Encyclopedia of Stress, 2nd Edition,
Elsevier, Academic Press, Oxford, UK, and San Diego, Vol 1, p 357-360
453.
Chrousos GP and Kaltsas G. (2007) Cardiovascular Disease, Stress In: Encyclopedia of Stress, 2nd Edition, Elsevier,
Academic Press, Oxford, UK, and San Diego, Vol. 1, p 410-416
454.
Bornstein SR, M. Gruber,H. S. Willenberg, C. A. Stratakis and Chrousos G. P. (2007) Cushing’s Syndrome,
Medical Aspects, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego,
Vol. 1, p 682-688
455.
Willenberg HS, S. R. Bornstein and Chrousos G. P. (2007) Disease, Stress Induced, In: Encyclopedia of Stress, 2nd
Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 824-828
456.
Makrigiannakis A, G. Petsas and Chrousos G. P. (2007) Eclampsia and Pre-Eclampsia, In: Encyclopedia of Stress,
2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 880-884
457.
Kalantaridou SN, T. Vrekoussis, A. Makrigiannakis and Chrousos G. P. (2007) Endometriosis, In: Encyclopedia of
Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego,Vol. 1, p 927-931
458.
Eleftheriades M, P. Pervanidou and Chrousos G. P. (2007) Fetal Stress, In: Encyclopedia of Stress, 2nd Edition,
Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 46-51
459.
Alevizaki M and Chrousos G. P. (2007) Heart Failure, Stress Effects, In: Encyclopedia of Stress, 2nd Edition,
Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 272-274
460.
Manoli I, S. Alesci and Chrousos G. P. (2007) Mitochondria, In: Encyclopedia of Stress, 2nd Edition, Elsevier,
Academic Press, Oxford, UK, and San Diego, Vol. 2, p 754-761
461.
*Makras P, Alexandraki KI, Chrousos GP, Grossman AB, Kaltsas GA (2007) Endocrine Manifestations in
Langerhans’ Cell Histiocytosis (LCH). Trends Endocrinol Metab 18(6):252-7.
462.
*Chrousos GP, Kino T (2007) Glucocorticoid action networks and complex psychiatric and/or somatic disorders.
Stress 10:213-219
463.
Kalantaridou SN, Zoumakis E, Makrigiannakis A, Godoy H, Chrousos GP. (2007) Role of Corticotropin-releasing
Hormone in Blastocyst Implantation and Early Fetal Immunotolerance. Horm Metab Res. 39:474-477.
464.
Pervanidou P, Chrousos GP. (2007) Post-traumatic Stress Disorder in Children and Adolescents: From Sigmund
Freud's "Trauma" to Psychopathology and the (Dys) metabolic Syndrome. Horm Metab Res. 39:413- 419
465.
*Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen, Bokhari F, Zaloga G, Annane D (2008)
Steroid Treatment in ARDS: a Critical Appraisal of the ARDS Network Trial and the Recent Literature. Crit Care
86
George P. Chrousos, M.D.
Med. 34:61-69
466.
*Diamanti-Kandarakis E, Papavassiliou AG, Kandarakis SA, Chrousos GP. (2007) Pathophysiology and types of
dyslipidemia in PCOS. Trends Endocrinol Metab. 2007 Aug 8; 18(7):280-5
467.
Chrousos GP (2007) Organization and Integration of the Endocrine System. The Sleep and Wakefulness
Perspective. Sleep Medicine Clinics 2: 125-145
468.
Trakada G, Chrousos GP, Pejovic S, Vgontzas AN (2007) Sleep Apnea and its Association with the Stress System,
Inflammation, Insulin Resistance and Visceral Obesity. Sleep Med Clin 2: 251–261
469.
Basta M, Chrousos G, Vela-Bueno A, Vgontzas AN (2007) Chronic Insomnia and the Stress System. Sleep Med
Clin 2: 279–291
470.
*Zoumakis E, Kalantaridou SN, Chrousos GP (2007) The “Brain-Skin Connection”: Nerve Growth Factordependent Pathways for Stress-Induced Skin Disorders J Mol Med 85(12):1347-9
471
Cutolo M, Straub R, Chrousos GP, Eds. (2006) Issue on Stress and Autoimmunity. Neuroimmunomodulation 13:
253-382
472.
*Priftis KN, Papadimitriou A, Nicolaidou P, Chrousos GP (2007) The Hypothalamic-pituitary-adrenal axis in
asthmatic children. Trends Endocrinol Metab 19:32-38
473.
Stefanaki C, Chrousos GP, Katsambas A (2007) Glucocorticoid and sex hormone receptors: clinical implications
and therapeutic relevance. Dermatol Clin. 25(4): 503-13.
473.
Kalantaridou SN, Zoumakis E, Weil S, Lavasidis LG, Chrousos GP, Makrigiannakis A. (2007) Reproductive
corticotropin releasing hormone, implantation, and fetal immunotolerance. Crit Rev Clin Lab Sci. 44: 461-81.
474.
*Marik PE, Pastores SM, Annane D, Meduri GU, Arlt W, Sprung CL, Keh D, Briegel J, Beishuizen A, Dimopoulou
I, Tsagarakis T, Singer M, MD; Chrousos GP, Zaloga G, Bokhari F, Vogeser M (2007) Clinical practice guidelines
for the diagnosis and management of corticosteroid insufficiency in critical illness: Recommendations of an
international task forc. Critical Care Medicine 36:1937-1949
475.
*Charmandari E, Kino T, Ichijo T, Chrousos GP (2008) Generalized Glucocorticoid Resistance: Clinical Aspects,
Molecular Mechanisms and Implications of a Rare Genetic Disorder. J. Clin Endocrinol. Metab. 93(5):1563-
1572
475.
Charmandari E, Kino T, Chrousos GP (2008) Generalized Glucocorticoid Insensitivity: Clinical Phenotype and
Molecular Mechanisms. Chapter 5. In: Overcoming Steroid Insensitivity in Respiratory Disease. Eds. Adcock AM
and Chung KF. J. Wiley Publ. Chichester, England p73-85
476.
Franchimont DP, Chrousos GP (2008) Glucocorticoid Resistance in Inflammatory Diseases. In Neuroimmune
Biology Vol 7. The Hypothalamus-Pituitary-Adrenal Axis. Eds. del Rey A, Chrousos G and Besedovsky, Elsevier
Co Oxford UK p349- 358`
477.
Zapanti E, Terzidis K, Chrousos G. (2008) Dysfunction of the Hypothalamic-Pituitary-Adrenal axis in HIV infection
and disease. Hormones (Athens) 3:205-216
478.
*Priftis C, Papadimitriou A, Nicolaidou P, Chrousos GP (2008) Testing for hypothalamic-pituitaryadrenal axis suppression in asthmatic children. Pediatr Allergy Immunol 19:466-7; author reply 468-70.
479.
Vgontzas AN, Bixler EO, Chrousos GP, Pejovic S (2008). Obesity and sleep disturbances: Meaningful
sub-typing of obesity. Arch Physiol Biochem. 114(4): 224-36
87
George P. Chrousos, M.D.
480.
*Priftis K N, Papadimitriou A, Nicolaidou P, GP Chrousos (2009) Dysregulation of the Stress Response
in Asthatic Children. Allergy 64: 18-31
481.
Chrousos GP, Kino T, Charmandari E (2008) Generalised Glucocorticoid Resistance. European
Endocrinology 4: 93-99
482.
*Chrousos GP (2009) Stress and Disorders of the Stress System. Nature Endocrinology Reviews 5(7):
374-81.
483.
*Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus
Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries
L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke
DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM. (2009)
Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009
Apr; 123(4): e752-62.
484.
Magiakou MA, Sarafoglou K, Stratakis C, and Chrousos GP (2008) Chapter 28. Cushing Syndrome in
Children and Adolescents. In Sarafoglou k, Hoffmann GF and Roth KS. (Eds) Pediatric Endocrinology
and Inborn Errors of Metabolism. McGraw Hill Co, New York p 411-418
485.
Gantenbein-Kanaka C and Chrousos GP (2008) Sudden Death in Adrenal Disease. Highlights 16: 9-12
486.
Priftis KN, Chrousos GP. (2009) Neuroimmunomodulation in asthma: focus on the hypothalamicpituitary-adrenal axis. Introduction. Neuroimmunomodulation 16(5):263-4.
487.
Priftis KN, Papadimitriou A, Anthracopoulos MB, Fretzayas A, Chrousos GP. (2009) Endocrine-immune
interactions in adrenal function of asthmatic children on inhaled corticosteroids.
Neuroimmunomodulation. 16(5): 333-9.
488.
Chrousos GP, Kino T, Charmandari E. (2009) Evaluation of the hypothalamic-pituitary-adrenal axis
function in childhood and adolescence. Neuroimmunomodulation 16(5):272-83.
489.
Pervanidou P, Kolaitis G and Chrousos GP ( 2009) Bio-Behavioral Consequences of Traumatic Stress in
Childhood and Adolescence: The Effects of War on Children’s Mental Health, Growth and Development.
In: War and Suicide, Sher L and Vilens A. (Eds) Nova Science Publ. Inc, in press
490.
*Kino T, Su YA, Chrousos GP (2009) Human glucocorticoid receptor isoform beta: recent understanding
of its potential implications in physiology and pathophysiology. Cell Mol Life Sci 66:3435-3448
491.
Chrousos GP and Kino T (2009) Glucocorticoid Signaling in the Cell: Expanding Clinical Implications to
Complex Human Behavioral and Somatic Disorders. In: Glucocorticoids and Mood: Clinical
Manifestations, Risk Factors, and Molecular Mechanisms. Proc. NY Acad Sci 1179: 153-166
492.
Chrousos G.P. (2009) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Eds. B.
Katzung, SB Masters, and AJ Trevor, Basic and Clinical Pharmacology, 11th Edition, Lange, McGrawHill, New York, New York. 681-697
493.
Chrousos G.P. (2009) Chapter 40. The Gonadal Hormones and Inhibitors. Eds. B. Katzung, SB Masters
and AJ Trevor, Basic and Clinical Pharmacology, 11th Edition, Lange, McGraw-Hill, New York, New
York 699-726
88
George P. Chrousos, M.D.
494.
Charmandari E, Chrousos GP, Kino T. (2009) Identification of Natural Human Glucocorticoid Receptor
(hGR) Mutations or Polymorphisms and Their Functional Consequences at the Hormone-Receptor
Interaction Level. Methods Mol Biol 590: 33-60
495.
*Meduri GU, Annane D, Chrousos GP, Marik PE, Sinclair SE. (2009) Activation and Regulation of
Systemic Inflammation in ARDS: Rationale for Prolonged Glucocorticoid Therapy. Chest 136: 16311643
496.
*Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E (2010) The Human Glucocorticoid
Receptor: Molecular Basis of Biologic Function. Steroids 75(1):1-12.
497.
Zoumakis E, Chrousos GP. (2010) Corticotropin-Releasing Hormone Receptor Antagonists: An Update.
Endocr Dev. 17: 36-43
498.
*Chrousos G (2009) Health and Climate Change. International Conference: Climate Change and
Challenges for the Future Generations. June 2-3, 2009, Athens, Greece. Livanis Publications, Athens,
Greece p 102-111.
499.
Kino T and Chrousos GP (2009) Tumor-associated, Estrogen Receptor-related Antigen EBAG9 as a
Potential Link between Intracellular Vesicle Trafficking, Immune Homeostasis and Malignancy. Mol
Interv 9: 294-298
500.
*Nader N, Chrousos GP and Kino T (2010) Interactions of the Circadian CLOCK System and the HPA
Axis. Trends Endocrinol Metab 21(5): 277-86
501.
*Kino T, James H. Segars JH and Chrousos GP (2010) The Guanine Nucleotide Exchange Factor Brx: A
Link between Osmotic Stress, Inflammation and Organ Physiology and Pathophysiology. Exp Rev
Endocrinol Metab 5: 603-614
.
502.
Tsara V, Amfilochiou A, Papagrigorakis JM, Georgopoulos D, Liolios E, Kadiths A, Koudoumnakis E,
Aulonitou E, Emporiadou M, Tsakanikos M, Chatzis A, Choulakis M, Chrousos G. (2010) Guidelines for
Diagnosing and Treating Sleep related Breathing Disorders in Adults and Children (Part 3: Obstructive
Sleep Apnea in Children, Diagnosis and Treatment). Hippokratia. 2010 Jan; 14(1): 57-62.
503.
Kaltsas G, Vgontzas A and Chrousos GP (2010) Fatigue, Endocrinopathies and Metabolic Disorders. PM
R 2:393-398
504.
Kanaka-Gantenbein C, Sakka S, Chrousos GP (2010) Assisted Reproduction and Its Neuroendocrine
Impact on the Offspring. Prog Brain Res. 182C:161-174
505.
Pervanidou P, Chrousos GP (2010) Neuroendocrinology of Post-Traumatic Stress Disorder. Prog Brain
Res. 182C: 149-160.
506.
*Papadimitriou A, Nicolaidou P, Fretzayas A, Chrousos GP (2010) Constitutional Advancement of
Growth, a.k.a. Early Growth Acceleration, Predicts Early Puberty and Childhood Obesity. J Clin
Endocrinol Metab. 2010 Jul 7. [Epub ahead of print]
507.
*Chrousos GP (2010) Perspective: Stress and Sex vs. Immunity and Inflammation. Science Signaling 3,
pe36
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George P. Chrousos, M.D.
508.
Vrekoussis T, Kalantaridou SN, Mastorakos G, Zoumakis E, Makrigiannakis A, Syrrou M, Lavasidis LG,
Relakis K, Chrousos GP (2010) The role of stress in female reproduction and pregnancy: an update. Ann
N Y Acad Sci. 2010 Sep; 1205(1):69-75. doi: 10.1111/j.1749-6632.2010.05686.x
509.
*Bacopoulou F, Greydanus DE, Chrousos GP (2010) Reproductive and contraceptive issues in
chronically ill adolescents. Eur J Contracept Reprod Health Care 15(6): 389-404.
510.
*Kino T, Chrousos GP. Acetylation-mediated Epigenetic Regulation of Glucocorticoid Receptor Activity:
Circadian Rhythm-associated Alterations of Glucocorticoid Actions in Target Tissues. Mol Cell
Endocrinol. 2010 Dec 9. [Epub ahead of print]
511.
*Kino T, Chrousos GP (2011) Circadian CLOCK-Mediated Regulation of Target-Tissue Sensitivity to
Glucocorticoids: Implications for Cardiometabolic Diseases. Endocr Dev. 2011; 20:116-26. Epub 2010
Dec 16
512.
Chrousos G (2011) Q&A: Primary Generalized Glucocorticoid Resistance. BMC Med 9:27
513.
*Kassi E, Pervanidou P, Kaltsas G, Chrousos G (2011) Metabolic Syndrome: Definitions and
Controversies. BMC Med. 2011 May 5; 9(1): 48. [Epub ahead of print]
514.
Pervanidou P, Chrousos GP (2011) Stress and Behavior: The Role of Nutrients with Emphasis on Omega3 Fatty Acids. Simopoulos AP (ed): Healthy Agriculture, Healthy Nutrition, Healthy People. World Rev
Nutr Diet. Basel, Karger, 2011, vol 102, pp 44–52
515.
*Malakasioti G, Gourgoulianis K, Chrousos G, Kaditis A. (2011) Interactions of obstructive sleepdisordered breathing with recurrent wheezing or asthma and their effects on sleep quality. Pediatr
Pulmonol. 2011 Aug 1. doi: 10.1002/ppul.21497. [Epub ahead of print]
516.
*Pervanidou P, Chrousos GP. (2011) Stress and obesity/metabolic syndrome in childhood and
adolescence. Int J Pediatr Obes. 2011 Sep; 6 Suppl 1:21-8.
517.
Pervanidou P and Chrousos GP (2011) Emotional/ Behavioral Disorders and Obesity in Childhood: A
Clinician’s Perspective. The European Health Psychologist 13: 48-51
518.
Kino T, Charmandari E, Chrousos GP Glucocorticoid receptor: implications for rheumatic diseases. Clin
Exp Rheumatol 2011; 29 (Suppl. 68): S32-S41.
519.
*Pervanidou P, Chrousos GP. Metabolic consequences of stress during childhood and adolescence.
Metabolism. 2011 Dec 5. [Epub ahead of print]
520.
Kino T, Charmandari E, and Chrousos GP. Disorders of the Hypothalamic-Pituitary-Adrenocortical
System. In: Fink G, Pfaff DW, Levine JE, eds. Handbook of Neuroendocrinology. London, Waltham,
San Diego: Academic press, Elsevier; 2012:639-658. ISBN: 9780123750976
521.
Tsitsami E, Dermentzoglou V, Moschovi M, and Chrousos GP (2011) Chronic Recurrent Multifocal
Osteomyelitis with Concomitant Features of Juvenile Idiopathic Arthritis. Case Rep Rheum (in press)
522.
* Chrousos GP, Kalantaridou SN, Margioris AN, Gravanis A (2012) The “Self-plagiarism” Oxymoron:
Can One Steal from Oneself? Eur J Clin Invest 2012 Jan 5 doi: 10.1111/j.1365-2362.2012.02645.x.
[Epub ahead of print]
90
George P. Chrousos, M.D.
523.
Halberg F, Cornélissen G, Czaplicki J, Schwartzkopff O, Sanchez de la Pena, S Finley J, Thomas F, Kino
T, and Chrousos G (2011) Coexisting wrestling lunisolar periods in a selenosensitive circulation rather
than circadian free-running? Leibniz Online 09/2011 Zeitschrift der Leibniz-Sozietät e. V. ISSN 18633285 http://www.leibniz-sozietaet.de/journal/archive/09_10/Halberg_et_al.pdf
524.
Chrousos G.P. (2012) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Eds. B.
Katzung, SB Masters, and AJ Trevor, Basic and Clinical Pharmacology, 12th Edition, Lange, McGrawHill, New York, New York. 697-713
525.
Chrousos G.P. (2012) Chapter 40. The Gonadal Hormones and Inhibitors. Eds. B. Katzung, SB Masters
and AJ Trevor, Basic and Clinical Pharmacology, 12th Edition, Lange, McGraw-Hill, New York, New
York 715-741
526.
Chrousos GP. (2012) Stress in Early Life: A Developmental and Evolutionary Perspective. In: Z. Hochberg
Evo-Devo of Child Growth. Wiley-Blackwell Co, Hoboken, NJ p29-40
527.
Kaltsas G, Zannas AS , and Chrousos GP (2012) Chapter 5. Hypothalamic–Pituitary–Adrenal Axis and
Cardiovascular Disease in P. Hjemdahl et al. (eds.), Stress and Cardiovascular Disease, DOI 10.1007/9781-84882-419-5_5, © Springer-Verlag London Limited 2012 p 71-87
528.
Kino T, Charmandari E, Chrousos GP (2012) Chapter 29. Disorders of the Hypothalamic-PituitaryAdrenocortical System. In: Fink G, Pfaff DW, Levine JE, eds. Handbook of Neuroendocrinology.
London, Waltham, San Diego: Academic Press, Elsevier; 2012:639-658. ISBN: 9780123750976, p 640654
529.
*Chrousos GP, Kalantaridou SN, Margioris AN, Gravanis A (2012) The “Self-plagiarism” Oxymoron:
Can One Steal from Oneself? Authors Reply. Eur J Clin Invest 2012 Mar 3. doi: 10.1111/j.13652362.2012.02664.x. [Epub ahead of print]
530.
Mischak H, Ioannidis JP, Argiles A, Attwood TK, Bongcam-Rudloff E, Broenstrup M, Charonis A,
Chrousos GP, Delles C, Dominiczak A, Dylag T, Ehrich J, Egido J, Findeisen P, Jankowski J, Johnson
RW, Julien BA, Lankisch T, Leung HY, Maahs D, Magni F, Manns MP, Manolis E, Mayer G, Navis G,
Novak J, Ortiz A, Persson F, Peter K, Riese HH, Rossing P, Sattar N, Spasovski G, Thongboonkerd V,
Vanholder R, Schanstra JP, Vlahou A. Implementation of proteomic biomarkers: making it work. Eur J
Clin Invest. 2012 Mar 27. doi: 10.1111/j.1365-2362.2012.02674.x. [Epub ahead of print]
531.
*Kaltsas G, Chrisoulidou A, Piaditis G, Kassi E, Chrousos G (2012) Current status and controversies in
adrenal incidentalomas. Trends Endocrinol Metab. 2012 Oct 4. pii: S1043-2760(12)00150-6. doi:
10.1016/j.tem.2012.09.001. [Epub ahead of print]
532.
Pervanidou P, Chrousos GP. (2012) Posttraumatic Stress Disorder in Children and Adolescents:
Neuroendocrine Perspectives. Sci Signal. 2012 Oct 9; 5(245): pt6.
533.
Charmandari E, Achermann JC, Carel JC, Soder O, Chrousos GP. (2012) Stress response and child
health. Sci Signal. 2012 Oct 30;5 (248):mr1
534.
Charmandari E, Kino T, Chrousos GP. Primary generalized familial and sporadic glucocorticoid
resistance (Chrousos syndrome) and hypersensitivity. Endocr Dev. 2013; 24:67-85. doi:
10.1159/000342505. Epub 2013 Feb 1.
535.
Contoreggi C, Lee MR, Chrousos G. Addiction and corticotropin-releasing hormone type 1 receptor antagonist
medications. Ann N Y Acad Sci. 2013 Feb 11. doi: 10.1111/nyas.12007. [Epub ahead of print]
91
George P. Chrousos, M.D.
536.
Tsiouli E, Alexopoulos EC, Stefanaki C, Darviri C, Chrousos GP. Effects of diabetes-related family stress on
glycemic control in young patients with type 1 diabetes: Systematic review. Can Fam Physician. 2013
Feb;59(2):143-9.
537.
Hatziavramidis DT, Karatzas TM, Chrousos GP. Pancreatic Islet Cell Transplantation: An Update. Ann Biomed
Eng. 2013 Mar; 41(3):469-476. Epub 2012 Oct 16.
538.
*Gold PW, Chrousos GP. Melancholic and atypical subtypes of depression represent distinct pathophysiological
entities: CRH, neural circuits, and the diathesis for anxiety and depression. Mol Psychiatry. 2013 Jun;18(6):632-4.
doi: 10.1038/mp.2013.5.
539.
Kassi EN, Chrousos GP. The central CLOCK system and the stress axis in health and disease. Hormones (Athens).
2012 Apr;12(2):172-91.
540.
Bacopoulou F and Chrousos GP 2013 Health Risk Behaviors and Resilience in Adolescence. In Education, Family
and Adolescent Health, Eds. AS Antoniou and BD Kirkaldy p141-154
541.
Kassi EN, Kaltsas G, Chrousos GP 2013 Stress, Trauma and the Impact on the Pituitary. The Hormone Factor in
Mental Health: Bridging the Mind-Body Gap. Ed. L. Rio, Jessica Kingsley publ, London p: 79-103
C.
BOOKS
1.
Chrousos G.P., Loriaux D.L., Lipsett M.B. (Eds) (1986) Steroid Hormone Resistance: Mechanisms and
Clinical Aspects. In the Series: Advances in Experimental Medicine and Biology, Vol. 196, Plenum
Press, New York, (439 pages, ISBN 0-306-42229-8).
2.
D'Agata R., Chrousos G.P. (Eds) (1987) Recent Advances in Adrenal Regulation and Function. Serono
Symposia Series, Vol. 40, Raven Press, New York, (311 pages, ISBN-0-8816-178-9).
3.
Chrousos G.P., Loriaux D.L., Gold P.W. (Eds) (1988) Mechanisms of Physical and Emotional Stress. In
the Series: Advances in Experimental Medicine and Biology, Vol. 245, Plenum Press, New York. (542
pages, ISBN-0-306-430-177).
4.
Ludecke D., Chrousos G.P., Tolis G. (Eds) (1990) Cushing's Syndrome and Other Hypercortisolemic
States. In the Series: Progress in Endocrine Research and Therapy, Vol. 5, Raven Press, New York (318
pages, ISBN-0-88167-718-3).
5.
Tolis G., Bringer J., Chrousos G.P. (Eds.) (1993) Intraovarian Regulators and the Polycystic-Ovary
Syndrome. Ann. New York Acad. Sci., Vol. 687, New York (320 pages, ISBN-089 766-779-4 and 0-89
766-780-8).
6.
Chrousos G.P., McCarty R., Cizza G., Pacak K., Sternberg E., Gold P.W., Kvetnanski R. (Eds.) (1995)
Stress: Mechanisms and Clinical Implications. Ann. New York Acad. Sci., Vol. 771, New York. (755
pages, ISBN 0-89766-943-6, cloth; 0-89766-944-4, paper).
7.
Creatsas G., Mastorakos G., Chrousos G.P. (Eds.) (1997) Adolescent Gynecology and Endocrinology:
Basic and Clinical Aspects. Ann. New York Acad. Sci., Vol. 816, New York. (470 pages, ISBN 157331-038-7, cloth; 1-57331-039-5, paper).
8.
McCann S., Sternberg E.M., Lipton J., Chrousos G.P., Gold P.W., Smith C. (Eds.) (1998)
92
George P. Chrousos, M.D.
Neuroimmunomodulation: Molecular Aspects, Integrative Systems and Clinical Advances. Ann.N.Y.
Acad. Sci. Vol. 840, New York (866 pages, ISBN 1-57331-072-7, cloth; 1-57331-073-5, paper).
9.
Creatsas G., Mastorakos G., Chrousos G. P., Eds. (2000) “The Young Woman at the Rise of the 21st
Century: Gynecological and Reproductive Issues in Health and Disease,” Ann. N.Y. Acad. Sci. 900: (445
pages, ISBN 1-57331-227-4).
10.
Margioris, A.N. and Chrousos, G.P. (Eds.) (2001) Adrenal Disorders. Humana Press: Totowa, New
Jersey, (424 pages, ISBN 0-89603-411-1).
11.
Chrousos G.P. Olefsky J.M. and Samols E. (Eds.) (2002) Hormone Resistance and Hypersensitivity
States. In Modern Endocrinology Series. Lippincott, Williams and Wilkins Publ. Co. Philadelphia Pa.
(542 pages, ISBN 0-7817-1497-4).
12.
Chrousos G.P. (Editor-in-chief)
www.eMedicine.com
13.
Chrousos G.P. (Associate Editor) (2003-) Adrenal Diseases. On-line Textbook, Endocrinology and
Metabolism, www.Endotext .com
14.
Chrousos G.P. (Associate Editor) (2004) Adrenal Physiology and Disorders. Encyclopedia of
Endocrinology and Endocrine Disorders, Elsevier, Academic Press, Oxford, UK, and San Diego, CA.
ISBN 0-12-475570-4 (set of 4 volumes)
15.
Creatsas G., Mastorakos G., Chrousos G. P., Eds. (2003) “Challenges on Women’s Health and Disease.
Ann. N.Y. Acad. Sci. Vol. 997 (390 pages, ISBN 1-57331-458-7).
16.
Geenen V. and Chrousos GP Eds. (2004) Immunoendocrinology in Health and Disease. Marcel Dekker
Inc. New York (ISBN: 0-8247-5060-8).
17.
Chrousos GP, Associate Editor (2007) Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press,
Oxford, UK, and San Diego, CA. (set of 3 volumes, ISBN: 978-0-12-088503-9).
18.
Kino T, Charmandari E, Chrousos G. Eds. (2004) Glucocorticoid Action: Basic and Clinical
Implications Ann N Y Acad Sci. Vol 1024 (221 pages, ISBN: 1-57331-557-5).
19.
Alesci S, Manoli I, Costello R, Oates P, Gold PW. Chrousos GP and Blackman M (Eds.) (2004)
Carnitine: The Science behind a Conditionally Essential Nutrient. Ann NY Acad Sci. Vol 1033 (199
pages, ISBN: 1-57331-555 -9)
20.
Chrousos GP; Tsigos C (Eds.) (2006) Stress, Obesity, and Metabolic Syndrome. Ann NY Acad Sci. Vol
1083 (345 pages, ISBN: 1-57331-625-3)
21.
Chrousos GP, Kaltsas GA, Mastorakos G (2006) Neuroendocrine and Immune Crosstalk. Ann NY Acad
Sci. Vol 1088, published Nov 2006 (412 pages, ISBN: 1-57331-623-7)
22.
Creatsas G, Mastorakos, Chrousos GP (2006) Women's Health and Disease: Gynecologic, Endocrine,
and Reproductive Issues. Ann NY Acad Sci. Vol 1092 (482 pages, ISBN: 0077-8923)
23.
Pandi-Perumal SR, Cardinali DP, Chrousos GP (2007) Neuroimmunology of Sleep. Springer Corp. (361
pages, ISBN: 0-387-69144-8)
(2002-)
Pediatric
Endocrinology
Electronic
Textbook,
93
George P. Chrousos, M.D.
24.
del Rey A, Chrousos G and Besedovsky H (2008) Neuroimmune Biology Vol 7. The HypothalamusPituitary-Adrenal Axis. Elsevier Co, Oxford UK (394 pages, ISBN 978-0-444-53040-0).
25.
Antoniou ASG, Cooper CL, Chrousos GP, Spielberger CD, Eysenck MW (2009) Handbook of Managerial
Behavior and Occupational Health. Edward Elgar Cheltenham Publishing Co, UK, Northhampton MA,
USA (452 pages, ISBN 978 1 848440951)
26.
Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff D (2010) Progress in Brain Research, Volume 181:
Neuroendocrinology, The Normal Neuroendocrine System, 1st Edition, Elsevier Science (ISBN:
9780444536174)
27.
Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff D (2010) Progress in Brain Research, Volume 182:
Neuroendocrinology, Pathological Situations and Diseases, 1st Edition, Elsevier Science (ISBN:
9780444537393)
28.
Ghizzoni L, Cappa M, Chrousos G, Loche S and Magghnie M, Eds (2011) Pediatric Adrenal Diseases. In
the Series: Endocrine Development Vol 20, S Karger AG. Basel (216 pages, ISBN 978-3-8055-9643-5)
29.
Koch, Christian A; Chrousos, George P, Eds. (2013) Endocrine Hypertension: Underlying Mechanisms
and Therapy Series: Contemporary Endocrinology 2013, XIII, 317 p. Humana Press Hardcover, Springer
(317 pages, 33 illus., 26 in color, ISBN 978-1-60761-547-7)