Appendix A: Confounders associated with perioperative spinal infection with an odds ratio of 1.2 – 2.5 Cerebrovascular Disease [430-438] Cerebrovascular disease Hypo or Hyper Calcium [275.42] Hypercalcemia [275.41] Hypocalcemia Peripheral Vascular Disease [443.9] Peripheral vascular disease, includes intermittent claudication [441-441.9] Aortic aneurysm [785.4] Gangrene Fracture [800-804] Fracture of skull [805-809] Fracture of neck and trunk [810-819] Fracture of upper limb [820-829] Fracture of lower limb Hypo or Hyper Thyroidism [252.0] Hyperparathyroidism [252.1] Hypoparathyroidism Confounders associated with perioperative spinal infection with an odds ratio of 2.5 – 3.5 Congestive Heart Failure [428-428.9] Heart Failure Dementia [290-290.9] Senile and pre-senile dementia Mild liver disease [571.2] Alcoholic cirrhosis [571.5] Cirrhosis without mention of alcohol [571.6] Biliary cirrhosis [571.4-571.49] Chronic hepatitis Rheumatologic Disease [710.0] Systemic lupus erythematosis [710.1] Systemic sclerosis [710.4] Polymyositis [714.0-714.2] Adult rheumatoid arthritis [714.81] Rheumatoid lung [725] Polymyalgia rheumatica Any malignancy, including leukemia and lymphyoma [140-172.9] Malignant neoplasms [174-195.8] Malignant neoplasms [200-208.9] Leukemia and lymphoma Renal Disease [582-582.9] Chronic glomerulonephritis 1 [583-583.7] Nephritis and nephropathy [585] Chronic renal failure [586] Renal failure, unspecified [588-588.9] Disorders resulting from impaired renal function Moderate or severe liver disease [572.2-572.8] Hepatic coma, portal hypertension, other sequelae of chronic liver disease [456.0-456.21] Esophageal varices Alcoholism [303.00 -303.93] Peptic Ulcer disease [531-534.9] Gastric duodenal and gastrojejunal ulcers Scar [709.2] Scar conditions and fibrosis of skin [701.4] Keloid scar Burns [940 – 949] Burns Diabetes with chronic complications [250.4-250.6] Diabetes with renal, ophthalmic, or neurological manifestations Confounders associated with perioperative spinal infection with an odds ratio of 3.5 – 4.5 Venous embolism and thrombosis of unspecified deep vessels of lower extremity [453.40] Metastatic solid tumor [196-199.1] Secondary malignant neoplasm of lymph nodes and other organs Dehydration [276.51] Confounders associated with perioperative spinal infection with an odds ratio of 4.5 - 5.5 Hemiplegia or paraplegia [344.1] Paraplegia [342-342.9] Hemiplegia Confounders associated with perioperative spinal infection with an odds ratio of 5.5 – 6.5 Thrombophlebitis [451.2] Phlebitis and thrombophlebitis of lower extremities, unspecified [451.8] phlebitis and thrombophlebitis of other sites [997.2] peripheral vascular complications, other [451.19] phlebitis and thrombophlebitis of other [451.11] phlebitis and thrombophlebitis of femoral vein deep or superficial. Confounders associated with perioperative spinal infection with an odds ratio of 6.5 – 7.5 Malnutrition [263.0] Malnutrition of moderate degree [263.1] Malnutrition of mild degree 2