CACODYLIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
CH7525000
Arsine oxide, dimethylhydroxy75-60-5
1736965
4-04-00-03681 (Beilstein Handbook Reference)
199812
59
C2-H7-As-O2
138.01
Q-AS-O&1&1
Agricultural Chemical
Tumorigen
Drug
Organometallic
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acide cacodylique
* Acide dimethylarsinique
* Ansar 138
* Arsan
* Arsinic acid, dimethyl* Chexmate
* Cotton aide HC
* Dimethylarsenic acid
* Dimethylarsinic acid
* Hydroxydimethylarsine oxide
* Kyselina kakodylova
* Phytar 138
* Phytar 600
* RCRA waste number U136
* Silvisar 510
* Sylvicor
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2600 mg/m3/2H
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,165,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REFERENCE :
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rat
2600 mg/m3/2H
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,165,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2600 mg/m3/2H
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,165,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2600 mg/m3/2H
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,165,1976
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 644 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 7,299,1986
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >2600 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,165,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 45,449,1997
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD295-864
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 185 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,393,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2260 mg/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
66,53,1993
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 464 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 4,49,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 4,49,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 4,49,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 42,651,1990
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE
: 4 gm/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 4,49,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1600 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
5,3,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3 gm/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - physical
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
4,403,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1600 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
5,3,1985
(Alan R. Liss,
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 2 pph
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 5 pph
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB268-647
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 720 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,47,1996
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 700 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
357,123,1996
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 7900 mg/kg/24H
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1413,33,1998
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1080 mg/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 23,39,1980
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: As,-,1977
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.5 mg(As)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,16,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993
OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993
OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84735
No. of Facilities: 88 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 309 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84735
No. of Facilities: 55 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 354 (estimated)
No. of Female Employees: 304 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP
reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA
without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Arsenic, organo-, 5022
CACODYLIC ACID SODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CH7700000
Arsine oxide, dimethylhydroxy-, sodium salt
124-65-2
199801
29
C2-H6-As-O2.Na
159.99
Q-AS-O&1&1 &-NAAgricultural Chemical
Drug
Organometallic
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Alkarsodyl
* Ansar 160
* Ansar 560
* Arsecodile
* Arsicodile
* Arsinic acid, dimethyl-, sodium salt
* Arsycodile
* Bolls-eye
* Cacodylate de sodium
* Cacodylic acid sodium salt
* Chemaid
* Dimethylarsinat sodny
* ((Dimethylarsino)oxy)sodium-As-oxide
* Dutch-treat
* Hydroxydimethylarsine oxide, sodium salt
* Kakodylan dodny
* Phytar 560
* Rad-E-Cate
* Rad-E-Cate 16
*
*
*
*
*
Rad-E-Cate 25
Rad-E-Cate 35
Sodium dimethylarsinate
Sodium, ((dimethylarsino)oxy)-, As-oxide
Sodium salt of cacodylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,70,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept.
of
National Health and Welfare, Food and Drug Divisions, 35 John St.,
Ottawa,
Ont., Canada)
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 900 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 29,679,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 900 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 29,679,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 9 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
386,279,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.5 mg(As)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,16,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993
OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993
OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84721
No. of Facilities: 34 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 136 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84721
No. of Facilities: 46 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 185 (estimated)
No. of Female Employees: 168 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CADMIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EU9800000
Cadmium
7440-43-9
199907
115
Cd
112.40
.CD
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Cadmium
* Cadmium dust fume
* Cadmium powder
* C.I. 77180
* Colloidal cadmium
* Kadmium
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 88 ug/m3/8.6Y
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
28,147,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 39 mg/m3/20M
TOXIC EFFECTS :
Cardiac - other changes
Vascular - thrombosis distant from injection site
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
31,180,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/m3/30M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 16,212,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 22(5),6,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
890 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor
Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
Inst., 1978 Volume(issue)/page/year: -,14,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,403,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 890 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 22(5),6,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 34,127,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PROTA* "Problemes de Toxicologie Alimentaire," Truhaut, R., Paris,
France,
L'evolution Pharmaceutique, 1955(?) Volume(issue)/page/year: -,-,1955
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Intravenous
: Rodent - rabbit
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOBSAK Journal of Obstetrics and Gynaecology of the British Empire.
(London,
UK) V.1-27, 1902-15; V.28-67, 1921-60. For publisher information, see
BJOGAS. Volume(issue)/page/year: 35,693,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 546 mg/kg/26W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 2,52,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1512 mg/kg/48W-C
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
5,105,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - pig
DOSE/DURATION
: 21880 mg/kg/78W-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 13,162,1993
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 129 ug/m3/20Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
10,153,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3372 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 55,40,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 1(1),51,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
Tumorigenic - tumors at site of application
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 31,224,1985
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
18,124,1964
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 63 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Tumorigenic - tumors at site of application
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 193,592,1962
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
155 mg/kg
male 13 week(s) pre-mating
female 13 week(s) pre-mating - 3 week(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 20,96,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 220 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.111,233,1982
1977-
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 21500 ug/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Newborn - germ cell effects (in offspring)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 22,466,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 23 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 158,614,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1124 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,194,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 ug/kg
SEX/DURATION
: female 19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A122,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 ug/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,264,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,264,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8 mg/kg
SEX/DURATION
: female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,264,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 448 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
23,102,1971
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
1700 mg/kg
female 8-12 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
6,361,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1686 ug/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,39A,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 31,52A,1985
** MUTATION DATA **
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 6 umol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
4,57,1990
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 umol/L
REFERENCE :
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth
Ave., New York, NY 10003) V.121973- Volume(issue)/page/year:
26,251,1980
*** REVIEWS ***
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.01 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 2,74,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 11,39,1976
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Human Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,139,1987
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX)
V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975
TOXICOLOGY REVIEW
JDSCAE Journal of Dairy Science. (American Dairy Science Assoc., 309 W.
Clark St., Champaign, IL 61820) V.11917- Volume(issue)/page/year:
58,1767,1975
TOXICOLOGY REVIEW
JFDSAZ Journal of Food Science. (Institute of Food Technologists, Suite
2120, 221 N. La Salle St., Chicago, IL 60601) V.261961Volume(issue)/page/year: 39,321,1974
TOXICOLOGY REVIEW
AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc.,
Maxwell House, Fairview Park, Elmsford, NY 10523) V.11972Volume(issue)/page/year: 3,55,1974
TOXICOLOGY REVIEW
QURBAW Quarterly Reviews of Biophysics. (Cambridge Univ. Press, The
Edinburgh Bldg., Shaftesbury Rd., Cambridge CB2 2RU, UK) V.11968Volume(issue)/page/year: 7,75,1974
TOXICOLOGY REVIEW
AEMBAP Advances in Experimental Medicine and Biology.
Corp.,
233 Spring St., New York, NY 10013) V.11967Volume(issue)/page/year:
40,239,1973
(Plenum Pub.
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB221-198
TOXICOLOGY REVIEW
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control.
(Kogai
Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka,
Minato-ku,
Tokyo 107, Japan) V.11965- Volume(issue)/page/year: 11,1300,1975
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
STEVA8 Science of the Total Environment.
(Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands)
Volume(issue)/page/year:
2,341,1974
V.1-
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology.
1972-
(London, UK)
V.1-19, 1963-81.
For
publisher information, see FCTOD7.
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
Volume(issue)/page/year: 9,105,1971
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 4,71,1971
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,63,1970
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
PDTNBH Paediatrician. (S. Karger AG, Postfach CH-4009 Basel,
Switzerland)
V.11972- Volume(issue)/page/year: 6,204,1977
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605
Third
Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
Volume(issue)/page/year: 3,209,1977
TOXICOLOGY REVIEW
GSAMAQ Memoir--Geological Society of America. (POB 9140, Boulder, CO
80302)
No.11934- Volume(issue)/page/year: 123,109,1971
TOXICOLOGY REVIEW
49DXAV "Health Evaluation of Heavy Metals in Infant Formula and Junior
Food,
Proceedings of the Symposium, 1981," Schmidt, E.H.F., and A.G.
Hildebrandt,
eds., Berlin, Springer-Verlag, 1983
Volume(issue)/page/year: -,57,1983
TOXICOLOGY REVIEW
43QNAO "Cadmium in the Environment," Nriagu, J.O., ed., 2 vols., New
York,
John Wiley & Sons, Inc., 1980-81 Volume(issue)/page/year: 2,743,1981
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,35,1971
OSHA PEL (Gen Indu):see CFR 29,1910.1027
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):see CFR 29,1926.1127
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):see CFR 29,1915.1027
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 mg(Cd)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.05 mg/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg/m3, JAN1999
OEL-FRANCE: VME 0.05 mg/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) dust 0.04 mg/m3, MAC(STEL) dust 0.2 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.02 mg/m3;STEL 0.1 mg/m3 JAN 1993
OEL-SWEDEN: TWA 0.01 mg/m3 (resp. dust), JAN1999
OEL-THE PHILIPPINES:TWA 0.2 mg/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg/m3;STEL 0.05 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg/m3;STEL 0.5 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0608
No. of Facilities: 48 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 96 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15570
No. of Facilities: 1256 (estimated)
No. of Industries: 41
No. of Occupations: 50
No. of Employees: 14717 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0608
No. of Facilities: 25 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 335 (estimated)
No. of Female Employees: 22 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2776
No. of Facilities: 248 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 3893 (estimated)
No. of Female Employees: 1887 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5979
No. of Facilities: 95 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 486 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 15570
No. of Facilities: 4811 (estimated)
No. of Industries: 77
No. of Occupations: 64
No. of Employees: 88968 (estimated)
No. of Female Employees: 14541 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/194476
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human
lymphocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 42, 1984
NIOSH Analytical Method, 1994: Cadmium and compounds, as Cd, 7048
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #ID-125G
CADMIUM ACETATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EU9810000
Cadmium(II) acetate
543-90-8
24558-49-4
29398-76-3
199712
34
C4-H6-O4.Cd
230.50
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acetic acid, cadmium salt
* Bis(acetoxy)cadmium
* Cadmium acetate
* Cadmium diacetate
* Cadmium ethanoate
* C.I. 77185
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 74900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK.
Pergamon Press Ltd., 1978
Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
49,41,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 328 mg/kg/23W-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
7,189,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 48889 ug/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 12,19,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15374 ug/kg/6W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 40,301,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 369 mg/kg/30D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
23,199,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 112 mg/kg/78W-C
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Vascular - BP elevation not characterized in autonomic section
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
69,149,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21532 ug/kg/21D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - alteration of classical conditioning
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
23,159,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16400 ug/kg/12W-I
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
Liver - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
18,245,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36913 ug/kg/45D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
27,59,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24608 ug/kg/30D-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
25,139,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49200 ug/kg/60D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - other changes
Nutritional and Gross Metabolic - conditioned vitamin deficiency
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 9,119,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1073 mg/kg/3W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.114,420,1969
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6205 ug/kg/5D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 16,190,1976
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2371 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 20,206,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2371 ug/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 20,206,1978
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
1 mg/kg
female 14 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 23,25,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 23,25,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2325 ng/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 17,559,1968
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
85,236,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,193,1979
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81747
No. of Facilities: 35 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 425 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81747
No. of Facilities: 134 (estimated)
No.
No.
No.
No.
of
of
of
of
Industries: 2
Occupations: 2
Employees: 329 (estimated)
Female Employees: 151 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell
transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CADMIUM ACETATE DIHYDRATE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
AF7505000
Acetic acid, cadmium salt, dihydrate
5743-04-4
199907
33
C4-H6-O4.Cd.2H2-O
266.54
OV1 2 &-CD- &QH 2
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Cadmium acetate dihydrate
* Cadmium diacetate dihydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
22,168,1979
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 128 mg/m3/2H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539392
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 109 ug/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
22,168,1979
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of
TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.81974Volume(issue)/page/year: 12(3),46,1978
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-POLAND: MAC(TWA) dust 0.04 mg(Cd)/m3, MAC(STEL) dust 0.2 mg(Cd)/m3,
JAN1999
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
CADMIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EV0175000
Cadmium chloride
10108-64-2
199907
254
Cd-Cl2
183.30
CD G2
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Caddy
* Cadmium dichloride
* Dichlorocadmium
* Kadmiumchlorid
* VI-Cad
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - acute pulmonary edema
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
292,1559,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 88 mg/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the
United States. (Denver, CO) V.3-38, 1939-74. Volume(issue)/page/year:
15,122,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 28,89,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15166 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,667,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5463 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,667,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
48,108,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9300 ug/kg
TOXIC EFFECTS :
Blood - hemorrhage
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 32,472,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3200 ug/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
48,108,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,510,1980
TYPE OF TEST
: LC90 - Lethal Concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 420 mg/m3/30M
TOXIC EFFECTS :
Cardiac - pulse rate
Lungs, Thorax, or Respiration - acute pulmonary edema
Gastrointestinal - nausea or vomiting
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,302,1947
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.511916- Volume(issue)/page/year: 97,269,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 233 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
11,201,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 233 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
11,201,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41PDA9 "Kadmium-Symposium, Jena, Ger. Dem. Rep., 1977," Bolck F., ed.,
Jena,
Ger. Dem. Rep., Abteilung Wissenschaftliche Pub., 1979
Volume(issue)/page/year: -,160,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - gerbil
DOSE/DURATION
: 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRMSAS Journal of the Royal Microscopical Society. (London, UK)
V.47-88,
1927-68. For publisher information, see JMICAR.
Volume(issue)/page/year:
85,297,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 85,249,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40040 mg/kg/65W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 14,205,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42770 ug/kg/6W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 40,273,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7162 mg/kg/47W-C
TOXIC EFFECTS :
Liver - other changes
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
15,95,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2808 mg/kg/83W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in calcium
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
54,223,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
412 mg/kg/4W-C
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
28,435,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1505 mg/kg/43W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
116,155,1992
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 33 ug/m3/24H/20W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Musculoskeletal - osteoporosis
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(5),85,1987
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 216 mg/kg/14W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - other changes
Nutritional and Gross Metabolic - changes in iron
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 2,929,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 270 mg/kg/26W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,521,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27397 ug/kg/40W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Biochemical - Metabolism (Intermediary) - effect on mitochondrial
function
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
24,215,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 mg/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
12,27,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49 mg/kg/7W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - other changes
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
12,131,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 mg/kg/16D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 63,342,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 63700 ug/kg/26D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
98,39,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg/10W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 22,255,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 293 mg/kg/30D-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 6,121,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
7338 ug/kg/9W-I
Liver - other changes
Liver - changes in liver weight
Blood - other changes
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
8,323,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 127 mg/kg/28W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney, Ureter, Bladder - proteinuria
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
77,414,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9780 ug/kg/8W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
18,268,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 73385 ug/kg/15W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Autonomic Nervous System - sympathomimetic
Behavioral - aggression
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
7,457,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 327 ug/m3/24H/66D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094)
V.1-
1966-
Volume(issue)/page/year: 17,585,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 81 mg/m3/4H/15D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.11989Volume(issue)/page/year: 3,419,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 65 mg/kg/13W-I
TOXIC EFFECTS :
Musculoskeletal - changes in teeth and supporting structures
Nutritional and Gross Metabolic - changes in iron
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 24,451,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2235 ug/kg/85D-C
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 9,29,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 185 mg/kg/22W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - fluid intake
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 55,193,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 275 mg/kg/10W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
30,598,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6825 mg/kg/65W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
70,85P,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 566 mg/kg/14D-C
TOXIC EFFECTS :
Blood - changes in spleen
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
86,39,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 mg/kg/14D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in spleen
Immunological Including Allergic - increase in cellular immune response
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
86,39,1996
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Subcutaneous
: Rodent - mouse
DOSE/DURATION
: 35 mg/kg/7W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in other cell count (unspecified)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 24,192,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8154 ug/kg/5D-I
TOXIC EFFECTS :
Blood - changes in spleen
Blood - changes in other cell count (unspecified)
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
19,29,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1369 mg/kg/24W-I
TOXIC EFFECTS :
Endocrine - evidence of thyroid hypofunction
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
34,85,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5547 mg/kg/54W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
31,4,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1522 mg/kg/43W-C
TOXIC EFFECTS :
Cardiac - cardiac output
Cardiac - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 8,322,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 686 mg/kg/40W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in platelet count
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
34,611,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 28750 ug/kg/23W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
12,360,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 156 mg/kg/32W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
6,225,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 63600 ug/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
61,105,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2250 ug/kg/3W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
KOAOAE Klinika Oczna. Eye Clinic. (Ars Polona, POB 100, 100-068 Warsaw,
Poland) V.11923- Volume(issue)/page/year: 93,1,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 1375 mg/kg/3W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
41PDA9 "Kadmium-Symposium, Jena, Ger. Dem. Rep., 1977," Bolck F., ed.,
Jena,
Ger. Dem. Rep., Abteilung Wissenschaftliche Pub., 1979
Volume(issue)/page/year: -,160,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 3179 mg/kg/26W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
41PDA9 "Kadmium-Symposium, Jena, Ger. Dem. Rep., 1977," Bolck F., ed.,
Jena,
Ger. Dem. Rep., Abteilung Wissenschaftliche Pub., 1979
Volume(issue)/page/year: -,160,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: 1803 mg/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 4,551,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: 630 mg/kg/42D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in adrenal weight
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 13,765,1984
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 ug/m3/23H/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,367,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3666 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,84,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4500 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - facilitates action of known carcinogen
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 83,493,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - facilitates action of known carcinogen
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 83,493,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6163 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology.
(Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)
1979- Volume(issue)/page/year: 114,273,1988
V.93-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5499 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
31,745,1963
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4500 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 83,493,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TC - Toxic concentration (other than lowest)
Inhalation
Rodent - rat
41 ug/m3/23H/78W-C
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,367,1983
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 82 ug/m3/23H/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,367,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7332 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,84,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5499 ug/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
Tumorigenic - tumors at site of application
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 115,653,1964
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3666 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106)
43,4575,1983
V.1-
1941-
Volume(issue)/page/year:
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7332 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,4575,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40770 ng/kg/2D-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
48,4656,1988
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,4282,1989
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 652 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK)
Volume(issue)/page/year: 2,255,1982
V.1-
1981-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 326 mg/kg
SEX/DURATION
: female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(4),86,1989
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
48 mg/kg
female 90 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-771017
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 14677 ug/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,222,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
17 mg/kg
male 6 week(s) pre-mating
female 6 week(s) pre-mating - 20 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
4,51,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
210 mg/kg
female 1-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
AHRTAN Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial
Hygiene and Toxicology. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade,
Yugoslavia) V.71956- Volume(issue)/page/year: 47,245,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 280 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 239,231,1972
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 ug/m3/24H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Maternal Effects - other effects
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 10,297,1978
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
REFERENCE :
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
600 ug/m3/24H
female 1-21 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 10,297,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 130 ug/m3
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(8),25,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 55 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.91987Volume(issue)/page/year:
19,213,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2933 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 7,237,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
2933 ug/kg
female 10 day(s) after conception
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 7,237,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,443,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,443,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,74A,1987
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4892 ug/kg
SEX/DURATION
: female 19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 18,103,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 32 mg/kg
SEX/DURATION
: female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 23,75,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
5,153,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
70,84P,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4500 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 44,259,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,443,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,443,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.11963Volume(issue)/page/year: 15,594,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6197 ug/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
33,36,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 248 gm/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 109,1640,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6 mg/kg
SEX/DURATION
: female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 1(3),187,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 33 mg/kg
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
CIZAAZ Chiba Igaku Zasshi. Chiba Medical Journal. (Chiba Daigaku
Igakkai,
1-8-1 Inohana, Chiba 280, Japan) V.501974Volume(issue)/page/year:
61,335,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 mg/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103) V.61958Volume(issue)/page/year: 30,2141,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 21,79,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1833 ug/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-771017
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1Volume(issue)/page/year: 187,641,1973
(Williams
1909/10-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 mg/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ZMAFA2 Zeitschrift fuer Mikroskopisch-Anatomische Forschung.
(Buchexport,
Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.11924Volume(issue)/page/year: 100,419,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 16,127,1977
V.1-
1968-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5700 ug/kg
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
EXPADD Experimental Pathology (1981). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.191981Volume(issue)/page/year:
36,75,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3666 ug/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 10,243,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2500 ug/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
11,127,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - mouse
73 mg/kg
male 1 day(s) pre-mating
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 4,164,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 20530 ug/kg
SEX/DURATION
: female 5-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
76,195,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Mammal - dog
DOSE
: 7330 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 14,613,1976
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Primate - monkey
DOSE
: 12 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73,
90141 Palermo, Italy) V.11969- Volume(issue)/page/year: 7,339,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 990 mg/kg
SEX/DURATION
: female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)
Volume(issue)/page/year: 70,323,1984
V.1-
1960-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 815 ug/kg
SEX/DURATION
: female 29 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,211,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1 mg/kg
SEX/DURATION
: female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 1,16,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 4583 ng/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 14,348,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2500 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)
V.11970- Volume(issue)/page/year: 26,181,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 5 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)
V.11970- Volume(issue)/page/year: 26,181,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 204 ug/kg
SEX/DURATION
: female 29 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,211,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1520 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.511916- Volume(issue)/page/year: 99,907,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 2500 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 3,50,1965
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 3666 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.11978Volume(issue)/page/year:
15,91,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 5 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - other measures of fertility
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
29,249,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 8 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
19,886,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,50A,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25,101,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
BMMBES Biochemical Medicine and Metabolic Biology. (Academic Press,
Inc.,
Journal Customer Service, POB 6250, Duluth, MN 55802-0250) V.351986Volume(issue)/page/year: 48,159,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - gerbil
DOSE
: 5600 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
JRMSAS Journal of the Royal Microscopical Society. (London, UK)
V.47-88,
1927-68. For publisher information, see JMICAR.
Volume(issue)/page/year:
85,297,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - squirrel
7332 mg/kg
male 1 day(s) pre-mating
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73,
90141 Palermo, Italy) V.11969- Volume(issue)/page/year: 7,257,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 7332 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 12,200,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 2400 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 18,1398,1980
1963-
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 500 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73,
90141 Palermo, Italy) V.11969- Volume(issue)/page/year: 7,75,1976
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
138,9,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 mg/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
13,737,1977
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 40 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 350 umol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
198,513,1977
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 20 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
259,147,1991
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 umol/L
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103) V.61958Volume(issue)/page/year: 33,1571,1985
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sex chromosome loss and nondisjunction
: Yeast - Saccharomyces cerevisiae
: 4 umol/L
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
1,21,1986
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 630 ug/L/4W (Continuous)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 36,199,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
193,237,1988
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 15 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 13,2389,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 50 umol/L/24H
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 10,67,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 1 umol/L
REFERENCE :
TKIZAM Tokyo Igaku Zasshi. Tokyo Journal of Medical Sciences. (Tokyo,
Japan) V.59-76, 1951-68. Volume(issue)/page/year: 82,232,1974
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
30,521,1992
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Sex chromosome loss and nondisjunction
: Human Lymphocyte
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,57,1993
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 300 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
198,115,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
61,450,1988
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 mg/kg/5D (Continuous)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,145,1976
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 12 mg/kg/3D (Intermittent)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
74,337,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 12 mg/kg/3D (Intermittent)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
74,337,1984
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 6 mg/kg/3D (Continuous)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,145,1976
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 nmol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
74,337,1984
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 3500 nmol/L
REFERENCE :
DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of
Sciences
of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11933Volume(issue)/page/year: 224,1189,1975
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1824 ug/kg
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11939Volume(issue)/page/year: 24,453,1962
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
306,85,1994
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 4900 ug/m3/1H (Continuous)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
80,215,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 4 mg/kg
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 40,13,1986
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA inhibition
: Rodent - mouse Cells - not otherwise specified
: 10 umol/L
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
84,379,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 32,472,1977
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,563,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 420 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,285,1988
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 840 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,285,1988
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 10 umol/kg
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 29,412,1982
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.130,365,1975
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 15 mg/kg
REFERENCE :
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag,
Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.61952Volume(issue)/page/year: 34,399,1980
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 140 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,85,1988
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 6 mg/kg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
13,737,1977
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 mg/kg
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 187,641,1973
V.1-
1909/10-
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20250 ug/kg
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.11920- Volume(issue)/page/year:
40,503,1959
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 mg/kg
REFERENCE :
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.11965-
(V/O
Volume(issue)/page/year: 16,1397,1980
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 500 ug/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 36,342,1986
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 625 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,71,1993
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 2 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,193,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2 umol/L
REFERENCE :
BIOJAU Biophysical Journal. (Rockefeller Univ. Press, 1230 York Ave.,
New
York, NY 10021) V.11960- Volume(issue)/page/year: 25,229a,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
111,69,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
131,173,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
137,103,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 500 ug/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 36,342,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1100 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,47,1993
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 250 ug/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 36,342,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
85,288,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 600 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,47,1993
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
111,69,1983
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Sperm Morphology
Subcutaneous
Rodent - hamster
40 umol/kg
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 1,294,1960
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - guinea pig
DOSE/DURATION
: 40 umol/kg
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 1,294,1960
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bird - chicken Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 12,173,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 350 umol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
198,513,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Mammal - species unspecified Kidney
DOSE/DURATION
: 2 umol/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 34,189,1985
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 40 umol/kg
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 1,294,1960
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 1000 ppm
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India)
V.1-
1958-
Volume(issue)/page/year: 28,176,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 2,74,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 11,39,1976
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology.
(London, UK)
V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 9,105,1971
TOXICOLOGY REVIEW
43QNAO "Cadmium in the Environment," Nriagu, J.O., ed., 2 vols., New
York,
John Wiley & Sons, Inc., 1980-81 Volume(issue)/page/year: 2,743,1981
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-SWITZERLAND;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84478
No. of Facilities: 68 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 447 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84478
No. of Facilities: 753 (estimated)
No. of Industries: 12
No. of Occupations: 13
No. of Employees: 4750 (estimated)
No. of Female Employees: 397 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell
transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss;
B
subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-rat; Sperm
morphology-rabbit
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human
lymphocyte
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated
assay
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
CADMIUM CHLORIDE HYDRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EV0178000
Cadmium chloride, hydrate (2:5)
7790-78-5
34330-64-8
199907
40
Cd-Cl2.5/2H2-O
228.35
Tumorigen
Mutagen
Reproductive Effector
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 665 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
103,28,1990
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
194 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 22,35,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4567 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,461,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 34320 ug/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
FMCRAW Folia Medica Cracoviensia. (Ars Polona, POB 1001, 00-068 Warsaw,
Poland) V.11959- Volume(issue)/page/year: 34,211,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1365 mg/kg/13W-C
TOXIC EFFECTS :
Cardiac - other changes
Vascular - structural changes in vessels
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
FMCRAW Folia Medica Cracoviensia. (Ars Polona, POB 1001, 00-068 Warsaw,
Poland) V.11959- Volume(issue)/page/year: 34,205,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 13650 ug/kg/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
KOAOAE Klinika Oczna. Eye Clinic. (Ars Polona, POB 100, 100-068 Warsaw,
Poland) V.11923- Volume(issue)/page/year: 95,377,1993
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 457 mg/kg/5W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
142,40,1997
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6237 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11953Volume(issue)/page/year: 29,P-46,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11939Volume(issue)/page/year: 34,329,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)
V.11970- Volume(issue)/page/year: 27,521,1983
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 28 umol/L
REFERENCE :
IAAAAM International Archives of Allergy and Applied Immunology.
Karger
Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.11950Volume(issue)/page/year: 79,83,1986
(S.
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 2290 ug/kg
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 17,436,1975
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 26 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,381,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
CADMIUM IODIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
EV1290000
Cadmium iodide
7790-80-9
199907
36
Cd-I2
366.20
Tumorigen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Cadmium diiodide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 81 mg/kg
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - urine volume increased
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
28,46,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 222 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - mouse
DOSE/DURATION
: 166 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor
Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
Inst., 1978 Volume(issue)/page/year: -,14,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg/29W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
9,142,1966
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 62 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(8),11,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 62 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
Volume(issue)/page/year: 50(8),11,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81748
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 238 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81748
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 7 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CADMIUM NITRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EV1750000
Cadmium nitrate
10325-94-7
14177-24-3
199907
42
N2-O6.Cd
236.42
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cadmium dinitrate
* Cadmium(II) nitrate
* Nitric acid, cadmium salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 22,455,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(3),57,1985
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor
Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
Inst., 1978
Volume(issue)/page/year: -,14,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(8),11,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(8),11,1985
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 300 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,143,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,143,1994
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 300 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,143,1994
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81749
No. of Facilities: 19 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 489 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81749
No. of Facilities: 169 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1878 (estimated)
No. of Female Employees: 378 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
CADMIUM NITRATE TETRAHYDRATE
RTECS NUMBER
: EV1850000
CHEMICAL NAME
: Cadmium(II) nitrate, tetrahydrate (1:2:4)
CAS REGISTRY NUMBER
: 10022-68-1
LAST UPDATED
: 199907
DATA ITEMS CITED
: 34
MOLECULAR FORMULA
: N2-O6.Cd.4H2-O
MOLECULAR WEIGHT
: 308.50
WISWESSER LINE NOTATION : CD N-O3*2
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Dusicnan kademnaty
* Cadmium dinitrate tetrahydrate
* Cadmium nitrate tetrahydrate
* C.I. 77192
* Nitric acid, cadmium salt, tetrahydrate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,12,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,12,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,12,1972
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6 umol/L
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 36,379,1985
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 493 nmol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.11984Volume(issue)/page/year: 5,15,1989
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5774
No. of Facilities: 90 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 179 (estimated)
No. of Female Employees: 179 (estimated)
CADMIUM OXIDE BROWN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EV1925000
Cadmium oxide
1306-19-0
199907
70
Cd-O
128.40
CD O
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Cadmium monoxide
* Cadmium oxide
* Kadmu tlenek
* NCI-C02551
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 8630 ug/m3/5H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 22,455,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 500 ug/m3/5Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - change in sensation of
smell
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
QJMEA7 Quarterly Journal of Medicine. (Oxford Univ. Press, Walton St.,
Oxford OX2 6DP, UK) V.11932- Volume(issue)/page/year: 38,425,1969
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 40 ug/m3
TOXIC EFFECTS :
Cardiac - change in rate
Vascular - BP elevation not characterized in autonomic section
Kidney, Ureter, Bladder - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
(V/O
Volume(issue)/page/year: 45(10),22,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 22,455,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZDKAA8 Zdravookhranenie Kazakhstana. Public Health of Kazakhstan.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11941Volume(issue)/page/year: 38(9),18,1978
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor
Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
Inst., 1978 Volume(issue)/page/year: -,14,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4 gm/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1500 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2500 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3500 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85PDAD "Evaluation of the Impact of Cadmium on the Health of Man",
Oxford,
UK. Pergamon Press Ltd., 1978 Volume(issue)/page/year: -,67,1978
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(7-9),187,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 156 ug/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Blood - other changes
Musculoskeletal - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(6),70,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23 ug/m3/24H/20W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Musculoskeletal - osteoporosis
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(5),85,1987
(V/O
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 57 ug/m3/90D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Blood - pigmented or nucleated red blood cells
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,231,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
300 ug/m3/6H/2W-I
Cardiac - changes in heart weight
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3388
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 ug/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3388
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 ug/m3/6H/13W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3388
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
20,190,1966
** REPRODUCTIVE DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
Reproductive - Effects
e.g., stunted fetus)
Reproductive - Effects
TDLo - Lowest published toxic dose
Oral
Rodent - rat
21640 ug/kg
female 1-19 day(s) after conception
on Embryo or Fetus - maternal-fetal exchange
on Embryo or Fetus - fetotoxicity (except death,
on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(8),11,1985
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 21640 ug/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(8),11,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
183 ug/m3/5H
female 21 week(s) pre-mating
female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
22,53,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
23 ug/m3/5H
female 21 week(s) pre-mating
female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
22,53,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - rat
DOSE
: 91 ug/m3
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(8),25,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/m3/6H
SEX/DURATION
: female 4-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3388
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 16 ug/m3/24H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(10),13,1981
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 mg/m3/6H
SEX/DURATION
: female 4-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3388
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 ug/m3/6H
SEX/DURATION
: female 4-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3388
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 2,74,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 11,39,1976
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 11,39,1976
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology.
(London, UK)
V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 9,105,1971
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France)
1946Volume(issue)/page/year: 34,127,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg/m3;Carcinogen (fume) JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-BELGIUM:STEL 0.05 mg/m3;Carcinogen (fume) JAN 1993
OEL-BELGIUM:TWA 0.05 mg/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.01 mg/m3;Carcinogen (fume) JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.05 mg/m3;Carcinogen JAN 1993
V.7-
OEL-SWEDEN: Carcinogen, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg/m3 (fume) JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg/m3 (fume) JAN 1993
OEL-THAILAND:TWA 0.1 mg/m3;STEL 0.3 mg/m3 (fume) JAN 1993
OEL-TURKEY:TWA 0.1 mg/m3 (fume) JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg/m3;STEL 0.5 mg/m3 (fume) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1554
No. of Facilities: 1127 (estimated)
No. of Industries: 37
No. of Occupations: 28
No. of Employees: 10110 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1554
No. of Facilities: 556 (estimated)
No. of Industries: 27
No. of Occupations: 31
No. of Employees: 15727 (estimated)
No. of Female Employees: 4850 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Cadmium and compounds, as Cd, 7048
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
NTP Toxicity studies, RPT# TOX-39, May 1999
CADMIUM SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
EV2700000
Cadmium sulfate (1:1)
10124-36-4
62642-07-3
31119-53-6
199907
69
O4-S.Cd
208.46
CD S-O4
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cadmium sulphate
* Sulphuric acid, cadmium salt (1:1)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor
Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
Inst., 1978 Volume(issue)/page/year: -,14,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 88 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
41HTAH "Aktual'nye Problemy Gigieny Truda. Current Problems of Labor
Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
Inst., 1978 Volume(issue)/page/year: -,14,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
6879 ug/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1317,1935
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35230 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
Volume(issue)/page/year: 50(8),11,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35230 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(8),11,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5150 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,407,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5150 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29,427,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 27,54A,1983
V.1-
1968-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1030 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29,427,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2570 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29,427,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 28 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
IGSBAL Igaku to Seibutsugaku. Medicine and Biology. (c/o Ogato Igaku
Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103,
Japan)
V.11942- Volume(issue)/page/year: 92,65,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2800 ug/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(2),30A,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 22,175,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 22,175,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 25,56,1969
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 6,95,1973
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 50 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
405,29,1998
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,299,1994
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,357,1983
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Micronucleus test
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 4300 ug/kg
REFERENCE :
GWZHEW Gongye Weisheng Yu Zhiyebing. Industrial Health and Occupational
Diseases. (China International Book Trading Corp., POB 2820, Beijing,
Peop.
Rep. China) V.11973- Volume(issue)/page/year: 12,77,1986
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 150 ug/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 9,367,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
265,45,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
265,45,1992
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 2,74,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 11,39,1976
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology.
(London, UK)
V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 9,105,1971
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
43QNAO "Cadmium in the Environment," Nriagu, J.O., ed., 2 vols., New
York,
John Wiley & Sons, Inc., 1980-81 Volume(issue)/page/year: 2,743,1981
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80247
No. of Facilities: 1041 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 15328 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80247
No. of Facilities: 79 (estimated)
No. of Industries: 5
No. of Occupations: 4
No. of Employees: 1313 (estimated)
No. of Female Employees: 172 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; B subtilis
rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
CADMIUM SULFATE HYDRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
EV2850000
Cadmium sulfate (1:1) hydrate (3:8)
7790-84-3
199907
36
O4-S.Cd.8/3H2-O
256.51
CD S-O2-Q2 *3 QH8
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cadmium sulfate octahydrate
* Sulfuric acid, cadmium salt, hydrate
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Tumorigenic - facilitates action of known carcinogen
REFERENCE :
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
16,111,1973
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
16,111,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 21,181,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 2 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 21,181,1980
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 3 umol/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
133,75,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 30 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,23,1994
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
40,125,1976
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
40,125,1976
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Cd)/m3, inhalable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg(Cd)/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 2,74,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,119,1993
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.2 mg(Cd)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,34,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-DENMARK: TWA 0.01 mg(Cd)/m3, JAN1999
OEL-FRANCE: VME 0.05 mg(Cd)/m3, JAN1999
OEL-FINLAND:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.05 mg(Cd)/m3, Group 1 Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-INDIA:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 mg(Cd)/m3;STEL 0.1 mg(Cd)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-RUSSIA:TWA 0.01 mg(Cd)/m3;STEL 0.05 mg(Cd)/m3 JAN 1993
OEL-SWEDEN:TWA 0.02 mg(Cd)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.05 mg(Cd)/m3 JAN 1993
OEL-THAILAND:TWA 0.2 mg(Cd)/m3;STEL 0.5 mg(Cd)/m3 JAN 1993
OEL-TURKEY:TWA 0.2 mg(Cd)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.01 mg(Cd)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CADMIUM, dust and fume-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
CAFFEINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
EV6475000
Caffeine
58-08-2
0017705
5-26-13-00558 (Beilstein Handbook Reference)
199812
189
C8-H10-N4-O2
194.22
T56 BN DN FNVNVJ B1 F1 H1
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Anhydrous caffeine
* Caffein
* Caffeina
* Coffein
* Coffeine
* Coffeinum
* 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
* Eldiatric C
* Guaranine
* Kofein
* Koffein
* Methyltheobromide
*
*
*
*
*
*
*
*
*
*
*
NCI-C02733
NO-Doz
Organex
1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethylThein
Theine
Theobromine, 1-methylTheophylline, 7-methyl
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethylxanthine
Xanthine, 1,3,7-trimethyl
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Skin and Appendages - sweating
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary
and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.191977- Volume(issue)/page/year:
39,228,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 140 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Cardiac - pulse rate increase, without fall in BP
Blood - hemorrhage
REFERENCE :
PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston
St.,
Baltimore, MD 21202) V.11985- Volume(issue)/page/year: 10,349,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 51 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Musculoskeletal - tumors
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 18,94,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 96 mg/kg/1D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.11932- Volume(issue)/page/year:
105,493,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Behavioral - toxic psychosis
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.781921Volume(issue)/page/year: 143,1320,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 192 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JNDRAK Journal of New Drugs. (Albany, NY) V.1-6, 1961-66. For
publisher
information, see JCPCBR. Volume(issue)/page/year: 5,252,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For
pub
lisher information, see FSINDR. Volume(issue)/page/year: 3,275,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
BIATDR Bulletin of the International Association of Forensic
Toxicologists.
Volume(issue)/page/year: -,6,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human
DOSE/DURATION
: 7 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
15,331,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 14700 ug/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
CLBIAS Clinical Biochemistry (Ottawa). (Laureen Dodge, Bus. Off.,
Ottawa,
Ont., Canada) V.11967- Volume(issue)/page/year: 10,148,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 68 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn
St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.1001960Volume(issue)/page/year: 134,495,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 57 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
15,331,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intramuscular
Human - infant
36 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn
St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.1001960Volume(issue)/page/year: 134,495,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 192 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - withdrawal
Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
JNDRAK Journal of New Drugs. (Albany, NY) V.1-6, 1961-66. For
publisher
information, see JCPCBR. Volume(issue)/page/year: 5,252,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZERNAL Zeitschrift fuer Ernaehrungswissenschaft. (Dr. Dietrich
Steinkopff
Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.) V.1- 1960Volume(issue)/page/year: 15,64,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCPHB8 Journal of Clinical Pharmacology and Journal of New Drugs.
(Albany,
NY) V.7-10, 1967-70. For publisher information, see JCPCBR.
Volume(issue)/page/year: 7,131,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 105 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Kidney, Ureter, Bladder - structural or functional changes in ureter
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1-
1909/10-
Volume(issue)/page/year: 82,89,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCPHB8 Journal of Clinical Pharmacology and Journal of New Drugs.
(Albany,
NY) V.7-10, 1967-70. For publisher information, see JCPCBR.
Volume(issue)/page/year: 7,131,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 127 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
44,1,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 168 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - aggression
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103) V.61958Volume(issue)/page/year: 22,1459,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 242 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 6,601,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 62 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
29,25,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 251 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
53,2S,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,174,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,174,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 224 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
44,1,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.)
Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 1,572,1910
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 58 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,791,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 1,572,1910
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 230 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
2,23,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.)
Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1335,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 230 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
44,1,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 1,572,1910
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
15,331,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - stiffness
Cardiac - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 12,355,1983
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 33210 mg/kg/90D-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 5,97,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 380 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in pituitary weight
Blood - changes in other cell count (unspecified)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 22,298,1984
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 39900 mg/kg/19W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(3),687,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE/DURATION
: 16800 mg/kg/8W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Endocrine - changes in thymus weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
22,365,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 157 gm/kg/75W-C
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(3),687,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1050 mg/kg/21D-I
TOXIC EFFECTS :
Behavioral - withdrawal
REFERENCE :
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press,
Great Clarendon St., Oxford OX2 6DP, UK) V.11987Volume(issue)/page/year: 11,219,1997
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30800 mg/kg/44W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - increased incidence of tumors in susceptible strains
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
48,2078,1988
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Human - woman
6750 mg/kg
SEX/DURATION
: female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,1415,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 3276 mg/kg
SEX/DURATION
: female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
POMDAS Postgraduate Medicine. (McGraw-Hill, Inc., 1221 Ave. of the
Americas, New York, NY 10020) V.11947- Volume(issue)/page/year:
62,64,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 1092 mg/kg
SEX/DURATION
: female 1-91 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
POMDAS Postgraduate Medicine. (McGraw-Hill, Inc., 1221 Ave. of the
Americas, New York, NY 10020) V.11947- Volume(issue)/page/year:
62,64,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 627 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 36,1105,1980
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
Reproductive - Effects
REFERENCE :
NTOTDY Neurobehavioral
TDLo - Lowest published toxic dose
Oral
Rodent - rat
85 mg/kg
female 3-19 day(s) after conception
on Newborn - behavioral
on Newborn - physical
Toxicology and Teratology.
(Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,29,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 13-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 26(3),8A,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1750 mg/kg
SEX/DURATION
: female 15-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,449,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 660 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
44,1,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
114 mg/kg
female 1-19 day(s) after conception
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FCHNA9 Food Chemical News. (1101 Pennsylvania Ave., SE, Washington, DC
20003) V.11959- Volume(issue)/page/year: 22(26),35,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 120 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 4,240,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 420 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 34,495,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 75 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25,95,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
200 mg/kg
male 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research.
Inc.,
41 E. 11th St., New York, NY 10003) V.11975Volume(issue)/page/year:
36,49,1980
(Alan R. Liss,
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 37500 ug/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 25(2),54A,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 25 mg/kg
SEX/DURATION
: female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,
Jena DDR-6900, Ger. Dem. Rep.) V.11886- Volume(issue)/page/year:
168,109,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 113 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 3,65,1983
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
1 gm/kg
female 8-12 day(s) after conception
on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 10,541,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 350 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
5,3,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1650 mg/kg
SEX/DURATION
: female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 23,57,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1650 mg/kg
SEX/DURATION
: female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 23,57,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
2691 mg/kg
female 5-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 23,57,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 250 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o
Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.11928Volume(issue)/page/year: 36,521,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 mg/kg
SEX/DURATION
: female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,427,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 19,134,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intraperitoneal
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 19,134,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 19,134,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 150 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 12,79,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 150 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 12,79,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw
Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.11929Volume(issue)/page/year: 29,316,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 26,751,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Multiple routes
Rodent - mouse
408 mg/kg
female 9 week(s) pre-mating
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 6,171,1966
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - hamster
8160 mg/kg
SEX/DURATION
: male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - sex ratio
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 43,141,1975
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6000 ppm/48H
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.11867- Volume(issue)/page/year:
85,119,1951
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1500 mg/L
REFERENCE :
MILEDM Microbios Letters. (Faculty Press, 88 Regent St., Cambridge, UK)
V.11976- Volume(issue)/page/year: 26,7,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1000 ppm/3M
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 118,373,1972
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland)
40,141,1982
V.1-
1969-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 2500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
117,55,1983
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
16,165,1972
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation in microorganisms
: Bacteria - Klebsiella pneumoniae
: 2 gm/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 25,85,1969
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2000 ppm
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 36,134,1950
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 400 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
43,37,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2500 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 150,301,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980-
Volume(issue)/page/year: 3,151,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 pph
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.11963Volume(issue)/page/year: 13,387,1975
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 30 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,151,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,151,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 5000 ppm
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 13,387,1975
1963-
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 3000 ppm
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
24,835,1986
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5000 ppm
REFERENCE :
GENEA3 Genetica (The Hague). (Kluwer Academic Pub. Group, Distribution
Centre, POB 322, 3300 AH Dordrecht, Netherlands) V.11919Volume(issue)/page/year: 44,146,1973
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.11867- Volume(issue)/page/year:
93,135,1959
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 750 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
167,35,1986
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 10 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 250 mg/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 31,97,1979
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 1000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
26,83,1974
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 100 ppm/8D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
125,275,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 750 umol/L
REFERENCE :
ASMACK Abstracts of the Annual Meeting of the American Society for
Microbiology. (American Soc. for Microbiology, 1913 I Street, NW,
Washington, DC 20006) Volume(issue)/page/year: 75,107,1975
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
BIOJAU Biophysical Journal. (Rockefeller Univ. Press, 1230 York Ave.,
New
York, NY 10021) V.11960- Volume(issue)/page/year: 35,665,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 mmol/L
REFERENCE :
RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St.,
Duluth,
MN 55802) V.11954- Volume(issue)/page/year: 37,334,1969
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 4 mmol/L
REFERENCE :
BIOJAU Biophysical Journal. (Rockefeller Univ. Press, 1230 York Ave.,
New
York, NY 10021) V.11960- Volume(issue)/page/year: 35,665,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
15,197,1972
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
3,249,1966
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 2600 umol/L/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,297,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 ug/L/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,205,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Embryo
DOSE/DURATION
: 50 ppm/24H
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi.
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1Volume(issue)/page/year: 46,337,1971
(Genetics Soc. of
1921-
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 500 mg/L
REFERENCE :
RBPMB2 Revista Brasileira de Pesquisas Medicas e Biologicas. Brazilian
Review of Medical and Biological Research. (Sao Paulo, Brazil) V.1-13,
1968-80. For publisher information, see BJMRDK.
Volume(issue)/page/year:
10,60,1977
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 91,135,1979
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - rat Kidney
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
189,299,1987
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 320 ug/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 200 umol/L
REFERENCE :
REXMAS Research in Experimental Medicine. (Springer-Verlag, Heidelberger
Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1571972Volume(issue)/page/year: 192,115,1992
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 7 mmol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980-
(Alan R. Liss,
Volume(issue)/page/year:
5,123,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,53,1986
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 35 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,120,1979
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 5,355,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 12,1781,1991
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 20,433,1982
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 208 mg/kg/7D (Continuous)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 22,608,1984
1963-
1963-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
26,73,1974
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
26,73,1974
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.11963Volume(issue)/page/year: 20,433,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 14 mg/kg/7D (Continuous)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 17,113,1994
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
60,329,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 7700 umol/L
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
32,178,1977
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Cytogenetic analysis
: Rodent - mouse Lymphocyte
: 100 mg/L
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,383,1983
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
60,329,1979
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg/5D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
122,347,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,213,1985
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2520 mg/kg/W (Continuous)
REFERENCE :
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.)
V.1-104, 1875-1979. Volume(issue)/page/year: 92,2315,1967
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,383,1983
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 150 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
243,109,1990
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Micronucleus test
Oral
Rodent - hamster
300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,53,1986
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 125 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
13,105,1976
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2444,1973
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2 mmol/L
REFERENCE :
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth
Ave., New York, NY 10003) V.121973- Volume(issue)/page/year:
41,202,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 mmol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 69,35,1971
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 25 mmol/L/2H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
12,463,1971
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 gm/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(96),55,1978
TYPE OF TEST
TEST SYSTEM
: Sister chromatid exchange
: Rodent - hamster Lung
DOSE/DURATION
: 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,21,1986
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,53,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Bird - chicken Fibroblast
DOSE/DURATION
: 25 mmol/L
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11913- Volume(issue)/page/year:
59,277,1972
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 100 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 48,686,1962
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,151,1982
*** REVIEWS ***
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 51,291,1991
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 51,291,1991
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 51,291,1991
TOXICOLOGY REVIEW
JIMRBV Journal of International Medical Research.
(Cambridge Medical
Pub.
Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)
1972Volume(issue)/page/year: 2,359,1974
V.1-
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
3,345,1975
TOXICOLOGY REVIEW
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO
63132) V.31969- Volume(issue)/page/year: 12,27,1974
TOXICOLOGY REVIEW
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).
(C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146)
Volume(issue)/page/year: 5,480,1964
V.1-
1960-
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For
pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,747,1989
TOXICOLOGY REVIEW
EPIRD7 Epidemiologic Reviews. (Johns Hopkins University, School of
Hygiene
and Public Health, Baltimore, MD 21205) V.11979Volume(issue)/page/year: 14,83,1992
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1132
No. of Facilities: 893 (estimated)
No. of Industries: 6
No. of Occupations: 7
No. of Employees: 5715 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1132
No. of Facilities: 1707 (estimated)
No. of Industries: 19
No. of Occupations: 23
No. of Employees: 19593 (estimated)
No. of Female Employees: 11199 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9210
No. of Facilities: 38 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 373 (estimated)
No. of Female Employees: 92 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; In vitro
cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-nondisjunction; N
crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; In vitro
SCE-human
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S
cerevisiae-aneuploidy
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro
cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Rodent dominant
lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In
vitro
SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Mouse specific locus; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: UDS in mouse germ cells; V79 cell
culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-nonhuman
bone
marrow
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent heritable translocation;
Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: Mouse spot test; B subtilis rec
assay
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-human lymphocytes;
In
vivo SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CALCIUM ACETATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Brown acetate
* Calcium acetate
* Calcium diacetate
* Gray acetate
* Lime acetate
* Lime pyrolignite
* Sorbo-calcion
* Teltozan
* Vinegar salts
:
:
:
:
:
:
:
:
:
AF7525000
Acetic acid, calcium salt
62-54-4
199701
8
C4-H6-O4.Ca
158.18
QV1 &-CAMutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 147 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 71,1,1941
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
6,447,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 203 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 29,809,1944
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 11,229,1988
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1290 umol/kg/5D (Intermittent)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1819,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81751
No. of Facilities: 1286 (estimated)
No. of Industries: 29
No. of Occupations: 27
No. of Employees: 10494 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81751
No. of Facilities: 5005 (estimated)
No. of Industries: 53
No. of Occupations: 43
No. of Employees: 65011 (estimated)
No. of Female Employees: 8166 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CALCIUM ACETATE MONOHYDRATE
RTECS NUMBER
: AF7875000
CHEMICAL NAME
: Acetic acid, calcium salt, monohydrate
CAS REGISTRY NUMBER
: 5743-26-0
LAST UPDATED
: 199504
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C4-H6-O4.Ca.H2-O
MOLECULAR WEIGHT
: 176.20
WISWESSER LINE NOTATION : OV1 2 &-CA- &QH
SYNONYMS/TRADE NAMES :
* Calcium acetate hydrate
* Calcium acetate monohydrate
* Calcium diacetate monohydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 4280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5427
No. of Facilities: 41 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 537 (estimated)
No. of Female Employees: 196 (estimated)
CALCIUM BISDIHYDROGENPHOSPHATE
RTECS NUMBER
: TB8527000
CHEMICAL NAME
: Phosphoric acid, calcium salt, hydrate (2:1:1)
CAS REGISTRY NUMBER
: 7758-23-8
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: Ca.2H3-O4-P
MOLECULAR WEIGHT
: 236.08
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Calcium phosphate, monobasic
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(12),87,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
(V/O
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(12),87,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84097
No. of Facilities: 661 (estimated)
No. of Industries: 11
No. of Occupations: 35
No. of Employees: 14370 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84097
No. of Facilities: 990 (estimated)
No. of Industries: 9
No. of Occupations: 14
No. of Employees: 18990 (estimated)
No. of Female Employees: 5892 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CALCIUM BROMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Calcium dibromide
:
:
:
:
:
:
:
:
:
EV9328000
Calcium bromide
7789-41-5
199712
8
Br2-Ca
199.90
.CA..E2
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
(V/O
Lungs, Thorax, or Respiration - respiratory depression
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539228
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 437 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 16,229,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 740 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 16,229,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 20,693,1980
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Ascites tumor
DOSE/DURATION
: 2300 mg/kg
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research.
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
54,155,1963
(Tokyo, Japan)
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1726
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 51 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CALCIUM CARBONATE
RTECS NUMBER
: FF9335000
CHEMICAL NAME
: Carbonic acid, calcium salt (1:1)
CAS REGISTRY NUMBER
: 471-34-1
LAST UPDATED
: 199710
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C-O3.Ca
MOLECULAR WEIGHT
: 100.09
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Aeromatt
* Akadama
* Albacar
* Albacar 5970
* Albafil
* Albaglos
* Albaglos SF
* Allied whiting
* Atomit
* Atomite
* AX 363
* BF 200
* Brilliant 15
* Brilliant 1500
* Britomya M
* Britomya S
* Calcene CO
* Calcene NC
* Calcene TM
* Calcicoll
* Calcidar 40
* Calcilit 8
* Calcilit 100
* Calcium carbonate (1:1)
* Calcium monocarbonate
* Calibrite
* Cal-Light SA
* Calmos
* Calmote
* Calofil A 4
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Calofil B 1
Calofil E 2
Calofort S
Calofort U
Calofor U 50
Calopake F
Calopake FS
Calopake H
Calopake high opacity
Calopake PC
Calseeds
Caltec
Camel-carb
Camel-tex
Camel-wite
Carbital 90
Carbium
Carbium MM
Carborex 2
Carusis P
CCC G-white
CCC No.AA oolitic
CCR
CCW
Chemcarb
Clefnon
C.I. Pigment White 18
Crystic prefil S
Dacote
DOMAR
Duramite
Durcal 10
Durcal 40
Durcal C 640305
Durcal 2NH
EGRI M 5
Eskalon 100
Eskalon 200
Eskalon 400
Eskalon 800
Eskalon 1500
Filtex White Base
Finncarb 6002
Garolite SA
Gilder's whiting
Hakuenka CC
Hakuenka CCR
Hakuenka DD
Hakuenka O
Hakuenka PX
Hakuenka PZ
Hakuenka R 06
Hakuenka T-DD
Homocal D
Hydrocarb 60
Hydrocarb 65
K 250
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Kotamite
Kredafil 150 Extra
Kredafil RM 5
KS 500
KS 1300
KS 1500
KS 1800
KS 2100
KULU 40
Levigated chalk
Marblewhite 325
Marfil
MC-T
Microcarb
Micromic CR 16
Micromya
Microwhite 25
Monocalcium carbonate
MSK-C
MSK-G
MSK-K
MSK-P
MSK-PO
MSK-V
Multiflex MM
Multiflex SC
N 34
N 43
NCC 45
NCC-P
Neoanticid
Neolite F
Neolite SP
Neolite TPS
Non-Fer-Al
NS
NS (carbonate)
NS 100
NS 100 (carbonate)
NS 200
NS 200 (filler)
NS 400
NS 2500
NZ
OA-A 1102
OMYA
Omya BLH
Omya BLP 2
Omya BLP 3
Omya BLR 3
Omya BLRZ
Omya bBSH
Omyacarb F
Omya D 40
Omya EXH 1
Omyalene G 200
Omyalite 90
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Omyalite BL
OS-Cal
Pigment White 18
P-Lite 500
P-Lite 700
Polcarb
Prepared chalk
PS 100
PS 100 (carbonate)
Purecal
Purecalo
Purecal SC
Purecal T
Purecal U
PZ
PZ (carbonate)
Queensgate whiting
Red ball
R Jutan
Royal White Light
RX 2557
RX 2558
RX 2559
Shipron A
Silver W
SL 700
Smithko kalkarb whiting
Snowcal
Snowcal 70
Snowcal 6ML
Snowcal 7ML
Snowflake White
Snow top
Socal
Socal D
Socal E 2
Socal N 2
Socal N 2S1
Socal P 2
Socal U 1
Socal U 3
Socal U 1S2
Softon 1000
Softon 1200
Softon 1500
Softon 1800
Softon 2200
Softon H
SS 30
SS 30 (carbonate)
SS 50
SS 50 (carbonate)
SSB 100
Stanwhite 500
Sturcal D
Sturcal H
Sturcal L
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Sturcal LS
Sturcal M
Sturcal X
Sunlight 700
Sunlight 800
Super 1500
Super 1700
Super 2000
Supercoat
Supermite
Super multifex
Super-pflex
Super 3S
Super 5S
Super SSS
Surfex MM
Surfil S
Suspenso
Sylacauga 88B
T 130-2500
Tama pearl TP 121
Tama pearl TP 262
Tancal 100
Tancal 200
Tancal PC
TM 1
TM 1 (filler)
Tonaso
Toyofine TF-X
TP 121
TP 121 (filler)
TP 222
TP 121 H
TP 222HS
Ultra-pflex
Unibur 70
Vevetone
Vicron
Vicron 31-6
Vicron 41-8
Vicron 15-15
Vicron 25-11
Vienna White
Vigot 15
Whica BA
Whitcarb W
White-powder
Whiting
Whiton 450
Whiton 1500
Whiton B
Whiton H
Whiton P 10
Whiton P 30
Whiton P 50
Whiton S
Whiton SB
*
*
*
*
*
*
*
*
*
*
*
Whiton SO
Whiton SS
Whiton SSB
Winnofil S
Witcarb
Witcarb P
Witcarb R
Witcarb RC
Witcarb regular
York White
ZG 301
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,267,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 750 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,267,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,267,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0841
No.
No.
No.
No.
of
of
of
of
Facilities: 1433 (estimated)
Industries: 17
Occupations: 12
Employees: 18263 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15705
No. of Facilities: 80902 (estimated)
No. of Industries: 338
No. of Occupations: 189
No. of Employees: 1002651 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6785
No. of Facilities: 1255 (estimated)
No. of Industries: 7
No. of Occupations: 16
No. of Employees: 20008 (estimated)
No. of Female Employees: 656 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9060
No. of Facilities: 292 (estimated)
No. of Industries: 4
No. of Occupations: 4
No. of Employees: 6239 (estimated)
No. of Female Employees: 2955 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 15705
No. of Facilities: 131230 (estimated)
No. of Industries: 392
No. of Occupations: 237
No. of Employees: 2341639 (estimated)
No. of Female Employees: 392183 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Calcium and compounds, 7020
CALCIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
:
:
:
:
:
EV9800000
Calcium chloride
10043-52-4
199710
33
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
: Ca-Cl2
: 110.98
: CA G2
: Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Calplus
* Caltac
* Dowflake
* Liquidow
* Peladow
* Snomelt
* Superflake anhydrous
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 20 mg/kg/1H-C
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.821960- Volume(issue)/page/year: 124,922,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNJMAQ Canadian Journal of Comparative Medicine and Veterinary Science.
(Gardenvale, Quebec, Canada) V.4-32, 1940-68. For publisher information,
see CJVRE9. Volume(issue)/page/year: 12,216,1948
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 264 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 14,963,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2630 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 14,963,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 161 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 15,35,1929
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29,
1943-71.
Suspended. Volume(issue)/page/year: 4,223,1946
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 14,963,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 210 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 34(5),51,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 823 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 14,963,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,150,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 274 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 274 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 249 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 249 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.)
Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1384 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 472 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 274 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraarterial
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 666 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1316,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2016 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Cardiac - pulse rate
Blood - changes in leukocyte (WBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 34(5),51,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 43 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - change in clotting factors
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 34(5),51,1990
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 112 gm/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40.
For
publisher information, see CNREA8. Volume(issue)/page/year: 23,550,1935
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 200 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
1,21,1986
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 2500 umol/kg
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11939Volume(issue)/page/year: 65,45,1975
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Ascites tumor
DOSE/DURATION
: 3500 mg/kg
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research.
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
54,155,1963
(Tokyo, Japan)
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15720
No. of Facilities: 7996 (estimated)
No. of Industries: 87
No. of Occupations: 79
No. of Employees: 110691 (estimated)
NOES - National Occupational
NOES Hazard Code - 15720
No. of Facilities: 15168
No. of Industries: 116
No. of Occupations: 113
No. of Employees: 354620
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
117433 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CALCIUM CHLORIDE DIHYDRATE
RTECS NUMBER
: EV9810000
CHEMICAL NAME
: Calcium chloride, dihydrate
CAS REGISTRY NUMBER
: 10035-04-8
LAST UPDATED
: 199504
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: Ca-Cl2.2H2-O
MOLECULAR WEIGHT
: 147.02
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Calcium dichloride dihydrate
* CAL plus
* Replenisher (calcium)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese
Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.11980- Volume(issue)/page/year:
4,110,1983
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 500 ug/kg
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 80,424,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3586
No. of Facilities: 1290 (estimated)
No. of Industries: 12
No. of Occupations: 23
No. of Employees: 19024 (estimated)
No. of Female Employees: 10290 (estimated)
CALCIUM FLUORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
EW1760000
Calcium fluoride
7789-75-5
199907
37
Ca-F2
78.08
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acid-spar
* Calcium difluoride
* Fluorspar
* Irtran 3
* Liparite
* Met-spar
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (2),28,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research
and
Development Reports. (Rochester, NY)
UR-154,1951
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2638 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 34,484,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983.
For publisher information, see 85KYAH. Volume(issue)/page/year:
11,253,1989
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine
and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow,
Russia)
No.11993- Volume(issue)/page/year: (7),32,1994
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44 gm/kg/31D-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Musculoskeletal - changes in teeth and supporting structures
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine
and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow,
Russia)
No.11993- Volume(issue)/page/year: (7),32,1994
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3200 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 34,124,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 67200 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 34,484,1979
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Ascites tumor
DOSE/DURATION
: 1 gm/kg
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research.
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
54,155,1963
(Tokyo, Japan)
*** REVIEWS ***
ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,116,1971
OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993
OEL-AUSTRIA: MAK 2.5 mg(F)/m3, JAN1999
OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 1 mg(HF)/m3, MAC(STEL) 3 mg(HF)/m3, JAN1999
OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993
OEL-RUSSIA:STEL 0.5 ppm (2.5 mg/m3) JAN 1993
OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993
OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0579
No. of Facilities: 840 (estimated)
No. of Industries: 17
No. of Occupations: 22
No. of Employees: 17561 (estimated)
NOES - National Occupational
NOES Hazard Code - M0579
No. of Facilities: 25299
No. of Industries: 187
No. of Occupations: 76
No. of Employees: 344071
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
3195 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CALCIUM FORMATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
LQ5600000
Formic acid, calcium salt
544-17-2
199709
7
C2-H2-O4.Ca
130.12
VHO 2 &-CAPrimary Irritant
*
*
*
*
Calcium diformate
Calcium formate
Calcoform
Mravencan vapenaty
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZERNAL Zeitschrift fuer Ernaehrungswissenschaft. (Dr. Dietrich
Steinkopff
Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.) V.1- 1960Volume(issue)/page/year: 9,332,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 154 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZERNAL Zeitschrift fuer Ernaehrungswissenschaft. (Dr. Dietrich
Steinkopff
Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.) V.1- 1960Volume(issue)/page/year: 9,332,1969
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82118
No. of Facilities: 28 (estimated)
No. of Industries: 2
No. of Occupations: 14
No. of Employees: 1554 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82118
No. of Facilities: 1045 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 14875 (estimated)
No. of Female Employees: 96 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CALCIUM GLUCONATE (D-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
EW2100000
Calcium gluconate
299-28-5
18016-24-5
199701
13
C12-H22-O14.Ca
430.42
QVYQYQYQYQ1Q 2 &-CADrug
Human
SYNONYMS/TRADE NAMES :
* Calcicol
* Calciofon
* Calcipur
* Calcium D-gluconate
* Calcium hexagluconate
* Calglucol
* Calglucon
* Dragocal
* Ebucin
* Glucal
* Glucobiogen
* Gluconate de calcium
* Gluconato di calcio
* D-Gluconic acid, calcium salt (2:1)
* Kalpren
* Novocal
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 143 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
129,347,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Brain and Coverings - meningeal changes
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
129,347,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia,
Italy)
V.8-43
1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 26,144,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,226,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Rodent - mouse
10 gm/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia,
Italy)
V.8-43
1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 26,144,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JDGRAX Journal of Drug Research. (National Organization for Drug
Research
and Control, POB 29, Cairo, Egypt) V.21969Volume(issue)/page/year:
15(1-2),121,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2890 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,47,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,492,1962
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1987 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 47,183,1933
TYPE OF TEST
ROUTE OF EXPOSURE
V.1-
: LDLo - Lowest published lethal dose
: Intravenous
1909/10-
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1810 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.41898- Volume(issue)/page/year: 191,44,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80373
No. of Facilities: 267 (estimated)
No. of Industries: 3
No. of Occupations: 11
No. of Employees: 14905 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80373
No. of Facilities: 565 (estimated)
No. of Industries: 3
No. of Occupations: 16
No. of Employees: 29060 (estimated)
No. of Female Employees: 23111 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CALCIUM HYDROXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Bell mine
* Biocalc
* Calcium dihydroxide
* Calcium hydrate
* Calcium hydroxide
:
:
:
:
:
:
:
:
:
EW2800000
Calcium hydroxide
1305-62-0
199907
28
Ca-H2-O2
74.10
CA Q2
Agricultural Chemical
Mutagen
Primary Irritant
*
*
*
*
*
*
*
*
*
*
Calvit
Carboxide
Hydrated lime
Kalkhydrate
Kemikal
Limbux
Lime milk
Lime water
Milk of lime
Slaked lime
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg
REACTION SEVERITY
: Severe
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
55,501,1980
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 32,1477,1981
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
GANNA2 Gann.
V.1-75,
: Cytogenetic analysis
: Rodent - rat Ascites tumor
: 1200 mg/kg
Japanese Journal of Cancer Research.
(Tokyo, Japan)
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
54,155,1963
*** REVIEWS ***
ACGIH TLV-TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 5 mg/m3, JAN1999
OEL-BELGIUM:TWA 5 mg/m3 JAN 1993
OEL-DENMARK: TWA 5 mg/m3, JAN1999
OEL-FINLAND:TWA 5 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 2 mg/m3, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CALCIUM HYDROXIDE-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15743
No. of Facilities: 15315 (estimated)
No. of Industries: 187
No. of Occupations: 115
No. of Employees: 226292 (estimated)
NOES - National Occupational
NOES Hazard Code - 15743
No. of Facilities: 20988
No. of Industries: 167
No. of Occupations: 131
No. of Employees: 360007
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
39330 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Calcium and compounds, 7020
CALCIUM HYPOCHLORITE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
NH3485000
Hypochlorous acid, calcium salt
7778-54-3
199710
12
C12-O2.Ca
216.20
CA G-Q*2
Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* B-K powder
* Bleaching powder
* Calcium chlorohydrochlorite
* Calcium hypochlorite
* Calcium oxychloride
* Caporit
* Chemichlor G
* Chloride of lime
* Chlorinated lime
* Chlorolime chemical
* HTH
* HTH (bleaching agent)
* HY-Chlor
* Lime chloride
* LO-Bax
* Losantin
* Perchloron
* Pittchlor
* Pittcide
* Pittclor
* Sentry
* Solvox KS
* T-Eusol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400
Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.11972Volume(issue)/page/year: 9,21,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Administration onto the skin
Rodent - rabbit
2 gm/kg
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570606
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/plate
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
22,623,1984
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 4 gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
22,623,1984
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 52,159,1991
IARC Cancer Review:Human No Available Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 52,159,1991
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 52,159,1991
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.154,7740,1989
1936-
Volume(issue)/page/year:
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15746
No. of Facilities: 3262 (estimated)
No. of Industries: 30
No. of Occupations: 37
No. of Employees: 39878 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 15746
No. of Facilities: 3884 (estimated)
No. of Industries: 48
No. of Occupations: 57
No. of Employees: 82721 (estimated)
No. of Female Employees: 23486 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CALCIUM NITRATE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
SYNONYMS/TRADE NAMES :
* Calcium dinitrate
* Calcium saltpeter
* Nitric acid, calcium
* Norge saltpeter
* Norway saltpeter
* Norwegian saltpeter
* Synfat 1006
EW2985000
Calcium(II) nitrate (1:2)
10124-37-5
199701
4
N2-O6.Ca
164.10
.CA..NO3*2
salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 302 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(12),66,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81753
No. of Facilities: 252 (estimated)
No. of Industries: 12
No. of Occupations: 12
No. of Employees: 2102 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81753
No. of Facilities: 350 (estimated)
No. of Industries: 13
No. of Occupations: 21
No. of Employees: 19867 (estimated)
No. of Female Employees: 10730 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CALCIUM NITRATE TETRAHYDRATE
RTECS NUMBER
: EW3000000
CHEMICAL NAME
: Calcium(II) nitrate, tetrahydrate (1:2:4)
CAS REGISTRY NUMBER
: 13477-34-4
LAST UPDATED
: 199809
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: N2-O6.Ca.4H2-O
MOLECULAR WEIGHT
: 236.18
WISWESSER LINE NOTATION : CA N-O3*2 &QH 4
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Calcium dinitrate tetrahydrate
* Calcium nitrate tetrahydrate
* Dusicnan vapenaty
* Nitric acid, calcium salt, tetrahydrate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: Standard Draize test
: Administration onto the skin
(V/O
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,9,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9989
No. of Facilities: 44 (estimated)
No. of Industries: 4
No. of Occupations: 11
No. of Employees: 3655 (estimated)
No. of Female Employees: 1593 (estimated)
CALCIUM OXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
:
:
:
:
:
:
EW3100000
Calcium oxide
1305-78-8
199907
32
Ca-O
MOLECULAR WEIGHT
: 56.08
WISWESSER LINE NOTATION : CA O
SYNONYMS/TRADE NAMES :
* Airlock
* BELL cml(E)
* Burnt lime
* Calcia
* Calcium oxide
* Caloxol CP2
* Caloxol W3
* CALX
* Calxyl
* CML 21
* CML 31
* Desical P
* Lime
* Lime, burned
* Oxyde de calcium
* Quicklime
* Rhenosorb C
* Rhenosorb F
* Wapniowy tlenek
*** REVIEWS ***
ACGIH TLV-TWA 2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 3 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,36,1971
OSHA PEL (Gen Indu):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5 mg/m3
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 2 mg/m3, JAN1999
OEL-AUSTRIA:TWA 5 mg/m3 JAN 1993
OEL-BELGIUM:TWA 2 mg/m3 JAN 1993
OEL-DENMARK: TWA 2 mg/m3, JAN1999
OEL-FINLAND:TWA 2 mg/m3 JAN 1993
OEL-GERMANY:TWA 5 mg/m3 JAN 1993
OEL-INDIA:TWA 2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2 ppm (5 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 2 mg/m3, MAC(STEL) 6 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993
OEL-SWEDEN:TWA 2 mg/m3;STEL 5 mg/m3 JAN 1993
OEL-TURKEY:TWA 5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CALCIUM OXIDE-air:10H TWA 2 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15755
No. of Facilities: 16328 (estimated)
No. of Industries: 158
No. of Occupations: 114
No. of Employees: 284781 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9892
No. of Facilities: 9 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 104 (estimated)
NOES - National Occupational
NOES Hazard Code - 15755
No. of Facilities: 38096
No. of Industries: 251
No. of Occupations: 153
No. of Employees: 726694
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
71548 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Calcium and compounds, 7020
OSHA ANALYTICAL METHOD #ID-125G
CALCIUM SULFATE DIHYDRATE
RTECS NUMBER
: EW4150000
CHEMICAL NAME
: Calcium(II) sulfate, dihydrate (1:1:2)
CAS REGISTRY NUMBER
: 10101-41-4
LAST UPDATED
: 199907
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: O4-S.Ca.2H2-O
MOLECULAR WEIGHT
: 172.18
WISWESSER LINE NOTATION : CA S-O4 &QH 2
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* Annaline
* C.I. 77231
* Compactrol
* Light spar
* Magnesia White
* Mineral White
* Native calcium sulfate
* Precipitated calcium sulfate
*
*
*
*
Satinite
Satin spar
Sulfuric acid, calcium(2+) salt, dihydrate
Terra alba
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:NUISANCE PARTICULATES
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,20,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993
OEL-FRANCE: VME 10 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2676
No. of Facilities: 3076 (estimated)
No. of Industries: 18
No. of Occupations: 32
No. of Employees: 37518 (estimated)
No. of Female Employees: 5940 (estimated)
CALCIUM SULFATE HEMIHYDRATE
RTECS NUMBER
: WS6920000
CHEMICAL NAME
: Sulfuric acid, calcium salt (1:1)
CAS REGISTRY NUMBER
: 7778-18-9
OTHER CAS REGISTRY NOS. : 23296-15-3
LAST UPDATED
: 199907
DATA ITEMS CITED
: 21
MOLECULAR FORMULA
: Ca.O4-S
MOLECULAR WEIGHT
: 136.14
SYNONYMS/TRADE NAMES :
* Anhydrous calcium sulfate
* Calcium sulfate
* Crysalba
* Drierite
* GIBS
* Thiolite
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3, Inhalable particulate
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 6 mg/m3, dust, JAN1999
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CALCIUM SULFATE, respirable fraction-air:TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CALCIUM SULFATE, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80244
No. of Facilities: 20643 (estimated)
No. of Industries: 155
No. of Occupations: 105
No. of Employees: 243889 (estimated)
NOES - National Occupational
NOES Hazard Code - 80244
No. of Facilities: 10251
No. of Industries: 76
No. of Occupations: 92
No. of Employees: 209809
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
25489 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAMPHOR
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
:
:
:
:
:
EX1260000
Camphor, (1R,4R)-(+)464-49-3
199701
9
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
C10-H16-O
152.26
L55 A CVTJ A1 A1 B1
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Alcanfor
* Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R)* (+)-2-Bornanone
* d-2-Bornanone
* d-2-Camphanone
* Camphor, (+)* (+)-Camphor
* d-Camphor
* D-(+)-Camphor
* Camphor USP
* Japanese camphor
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
TYPE OF TEST
: LD90 - Lethal Dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 525 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,665,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB92-170034
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CAMPHOR
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
EX1225000
Camphor
76-22-2
3196099
4-07-00-00213 (Beilstein Handbook Reference)
199907
51
C10-H16-O
152.26
L55 A CVTJ A1 A1 B1
Agricultural Chemical
Tumorigen
Drug
Mutagen
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl* Bornane, 2-oxo* 2-Bornanone
* 2-Camphanone
* Camphor, synthetic
* Camphor, natural
* Formosa camphor
* Gum camphor
* Huile de camphre
* Japan camphor
* 2-Kamfanon
* Kampfer
* 2-Keto-1,7,7-trimethylnorcamphane
* Laurel camphor
* Matricaria camphor
* Norcamphor, 1,7,7-trimethyl* 1,7,7-Trimethylbicyclo(2.2.1)-2-heptanone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 30,857,1954
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 51 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders,
Philadelphia,
PA) V.11983- Volume(issue)/page/year: 7,41,1989
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,1499,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 65,275,1939
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
V.1-
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - rat
70 mg/kg
1909/10-
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CDGU** "Ueber die Pharmakologische Wirkung eines dem
Pentamethylentetrazol
(Cardiazol) nahestehenden stickstoffhaltigen Kampherab-Kommlings,
Dissertation," Czygan, H.H., Hessischen Ludwigs- Universitat zu Giessen,
Fed. Rep. Ger., 1934 Volume(issue)/page/year: -,-,1934
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SHGKA3 Shika Gakuho. Journal of Dentistry. (Tokyo Shika Daigaku Gakkai,
1-2-2 Masago, Chiba 260, Japan) V.11895- Volume(issue)/page/year:
75,934,1975
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/m3/3H
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 22(11),83,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - rigidity (including catalepsy)
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 30,857,1954
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
REFERENCE :
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen,
G.,
Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933
Volume(issue)/page/year: -,-,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - rigidity (including catalepsy)
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 30,857,1954
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 50,199,1903
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
210 mg/m3/3H/7W-I
Lungs, Thorax, or Respiration - emphysema
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 22(11),83,1957
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 33 mg/m3/3H/7W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Cardiac - other changes
Lungs, Thorax, or Respiration - emphysema
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 22(11),83,1957
(V/O
(V/O
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,157,1989
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 19 mg/m3 (3 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 12 mg/m3 (2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO
63132) V.31969- Volume(issue)/page/year: 12,27,1974
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB293-503
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 2 ppm (12 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,37,1971
OSHA PEL (Gen Indu):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 2 ppm (13 mg/m3), JAN1999
OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993
OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993
OEL-DENMARK: TWA 2 ppm (12 mg/m3), JAN1999
OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993
OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 12 mg/m3, MAC(STEL) 18 mg/m3, JAN1999
OEL-RUSSIA:STEL 3 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 15800
No. of Facilities: 8356 (estimated)
No. of Industries: 68
No. of Occupations: 63
No. of Employees: 95578 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1190
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 427 (estimated)
No. of Female Employees: 176 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 15800
No. of Facilities: 9166 (estimated)
No. of Industries: 101
No. of Occupations: 87
No. of Employees: 153554 (estimated)
No. of Female Employees: 53187 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ketones II, 1301
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
CAMPHOR (-)RTECS NUMBER
: EX1250000
CHEMICAL NAME
: Camphor, (1S,4S)-(-)CAS REGISTRY NUMBER
: 464-48-2
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C10-H16-O
MOLECULAR WEIGHT
: 152.26
WISWESSER LINE NOTATION : L55 A CVTJ A1 A1 B1
SYNONYMS/TRADE NAMES :
* (-)-Alcanfor
* Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1S)* l-Camphor
* l-(-)-Camphor
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 1,445,1909
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02534
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CAMPHORSULFONIC ACID (BETA,10-)
RTECS NUMBER
: ED1550000
CHEMICAL NAME
: 10-Bornanesulfonic acid, 2-oxo-, (1S,4R)-(+)CAS REGISTRY NUMBER
: 3144-16-9
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C10-H16-O4-S
MOLECULAR WEIGHT
: 232.32
SYNONYMS/TRADE NAMES :
* Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-,
(1S)* Camphersulfosaeure
* Camphorsulfonic acid
* (+)-Camphorsulfonic acid
* (+)-beta-Camphorsulfonic acid
* d-Camphorsulfonic acid
* d-10-Camphorsulfonic acid
* Reychler's acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2502 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
1,150,1946
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CAPRIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
:
:
HD9100000
Decanoic acid
334-48-5
1754556
4-02-00-01041 (Beilstein Handbook Reference)
199710
8
C10-H20-O2
172.30
QV9
Mutagen
Primary Irritant
*
*
*
*
*
*
*
*
*
*
*
Capric acid
n-Capric acid
Caprinic acid
Caprynic acid
n-Decanoic acid
n-Decoic acid
Decylic acid
n-Decylic acid
Hexacid 1095
Neo-fat 10
1-Nonanecarboxylic acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,735,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
37,251,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 129 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
18,141,1961
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sex chromosome loss and nondisjunction
: Yeast - Saccharomyces cerevisiae
: 14500 ppb
ANYAA9 Annals of the New York Academy of Sciences.
Sciences, 2 E. 63rd St., New York, NY 10021) V.1Volume(issue)/page/year: 407,186,1983
(New York Academy of
1877-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84495
No. of Facilities: 270 (estimated)
No. of Industries: 8
No. of Occupations: 9
No. of Employees: 2910 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84495
No. of Facilities: 703 (estimated)
No. of Industries: 9
No. of Occupations: 15
No. of Employees: 7879 (estimated)
No. of Female Employees: 945 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPROIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MO5250000
Hexanoic acid
142-62-1
0773837
4-02-00-00917 (Beilstein Handbook Reference)
199710
20
C6-H12-O2
116.18
QV5
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Butylacetic acid
* n-Caproic acid
* Capronic acid
* Hexacid 698
* n-Hexanoic acid
* n-Hexoic acid
* Kyselina kapronova
* Pentanecarboxylic acid
* Pentiformic acid
* Pentylformic acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 465 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/2/1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 750 ug
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2050 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/2/1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982
Volume(issue)/page/year: -,32,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4100 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,32,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 21,85,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 21,85,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1725 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
18,141,1961
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
630 uL/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25200 mg/kg/3W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,379,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Non-mammalian species Cells - not otherwise
specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
40,1,1973
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Non-mammalian species Cells - not otherwise
specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
40,1,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84192
No. of Facilities: 60 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 1526 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84192
No. of Facilities: 735 (estimated)
No. of Industries: 8
No. of Occupations: 14
No. of Employees: 10060 (estimated)
No. of Female Employees: 3562 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPROIC ACID ETHYL ESTER
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Ethyl caproate
* Ethyl hexanoate
:
:
:
:
:
:
:
:
:
:
:
MO7735000
Hexanoic acid, ethyl ester
123-66-0
1701293
4-02-00-00921 (Beilstein Handbook Reference)
199710
4
C8-H16-O2
144.24
5VO2
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,761,1976
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1824
No. of Facilities: 45 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 678 (estimated)
No. of Female Employees: 380 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPROIC ACID METHYL ESTER
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Methyl caproate
* Methyl capronate
* Methyl hexanoate
* Methyl n-hexanoate
* Methyl hexoate
* Methyl hexylate
MO8401400
Hexanoic acid, methyl ester
106-70-7
1744683
4-02-00-00921 (Beilstein Handbook Reference)
199710
10
C7-H14-O2
130.21
Natural Product
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,745,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,82,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RESJAS Journal of the Reticuloendothelial Society. (1964) (Res: Journal
of
the Reticuloendothelial Society, New York) V.1(1)-14(6), 1964-73.
Volume(issue)/page/year: 3,250,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,745,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 11500 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0807
No. of Facilities: 28 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 476 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0807
No. of Facilities: 42 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 255 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPROLACTAM (EPSILON-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
CM3675000
2H-Azepin-2-one, hexahydro105-60-2
0106934
5-21-06-00444 (Beilstein Handbook Reference)
199907
89
C6-H11-N-O
113.18
T7MVTJ
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* A1030
* 6-Aminocaproic acid lactam
* Aminocaproic lactam
* 6-Aminohexanoic acid cyclic lactam
* 1-Aza-2-cycloheptanone
* 2-Azacycloheptanone
* 2H-Azepin-7-one, hexahydro* Caprolactam
* epsilon-Caprolactam
* omega-Caprolactam
* epsilon-Caprolactam
* 6-Caprolactam
* Caprolactam monomer
* Caprolattame
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Capron PK4
Cyclohexanone iso-oxime
Epsilon-caprolactam
Epsylon kaprolaktam
Extrom 6N
Hexahydro-2-azepinone
Hexahydro-2H-azepin-2-one
Hexamethylenimine, 2-oxo6-Hexanelactam
Hexanoic acid, 6-amino-, cyclic lactam
Hexanoic acid, 6-amino-, lactam
Hexanolactam
Hexanone isoxime
Hexanonisoxim
1,6-Hexolactam
e-Kaprolaktam
Kapromine
2-Ketohexamethyleneimine
2-Ketohexamethylenimine
NCI-C50646
2-Oxohexamethyleneimine
2-Oxohexamethylenimine
2-Perhydroazepinone
Stilon
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,883,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,883,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,384,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1210 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - chromodacryorrhea
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-214,1982
(Research
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,32,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
11,1,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 580 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(10),33,1990
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 930 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 10(10),54,1966
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 450 mg/m3
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 10(10),54,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 650 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
Behavioral - analgesia
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 60,1058,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,247,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Rodent - mouse
480 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,247,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 930 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(10),33,1990
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1410 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
11,1,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(10),33,1990
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8,
20122
Milan, Italy) V.161925- Volume(issue)/page/year: 43,124,1952
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 50,199,1903
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/8W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,9,1959
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 243 mg/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TOSCF2 Toxicological Sciences. (Academic Press, 6277 Sea Harbor Dr.,
Orlando, FL 32887) V.411998- Volume(issue)/page/year: 44,197,1998
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
5960 mg/kg/82D-C
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(1),22,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9100 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in other cell count (unspecified)
Related to Chronic Data - death
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 18,357,1967
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 7,317,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537802
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
125 mg/m3/24H
male 76 day(s) pre-mating
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(10),40,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 473 mg/m3/4H
SEX/DURATION
: female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 34(7),25,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 139 mg/m3/4H
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 34(7),25,1969
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 473 mg/m3/4H
SEX/DURATION
: female 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(10),22,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rabbit
3450 mg/kg
female 6-28 day(s) after conception
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 7,317,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537802
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1950 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,313,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,339,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
5,271,1985
V.1-
1981-
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 400 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,271,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 100 ppm
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,17,1989
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 mmol/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland)
V.41957- Volume(issue)/page/year: 33,699,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 270 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,457,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 25 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,333,1989
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 580 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,379,1989
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Ovary
DOSE/DURATION
: 76 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
143,263,1985
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 125 mg/m3/10W
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(10),40,1975
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,369,1989
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 2500 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,639,1985
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 580 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,379,1989
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 100 mg/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
2,103,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 8 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,427,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 125 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,333,1989
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 23 mg/m3 (5 ppm) (vapor)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 46 mg/m3 (10 ppm) (vapor)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 3 mg/m3 (dust)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1 mg/m3 (dust)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal NO EVIDENCE
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,247,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,247,1986
IARC Cancer Review:Group 4
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 mg/m3;STEL 3 mg/m3 (dust) JAN 1993
OEL-AUSTRIA: MAK 5 mg/m3 (dust), JAN1999
OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);STEL 10 ppm (vapor) JAN 1993
OEL-AUSTRIA:TWA 25 mg/m3 (dust) JAN 1993
OEL-DENMARK: TWA 1 mg/m3 (dust), JAN1999
OEL-BELGIUM:TWA 1 mg/m3;STEL 3 mg/m3 (dust) JAN 1993
OEL-BELGIUM:TWA 4.3 ppm (20 mg/m3);STEL 8.6 ppm (40 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 10 mg/m3 (dust) JAN1999
OEL-SWEDEN: TWA 5 mg/m3, STEL 10 mg/m3, JAN1999
OEL-FINLAND:TWA 1 mg/m3;STEL 3 mg/m3 (dust) JAN 1993
OEL-FINLAND:TWA 5 ppm (20 mg/m3);STEL 10 ppm (46 mg/m3) (vapor) JAN 1993
OEL-GERMANY:TWA 25 mg/m3 (dust) JAN 1993
OEL-GERMANY:TWA 25 mg/m3 JAN93(vapor)
OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 (dust) JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg/m3 (vapor) JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3) (dust) JAN 1993
OEL-RUSSIA:STEL 10 mg/m3 (dust) JAN 1993
OEL-SWITZERLAND:TWA 4 ppm (20 mg/m3) (vapor) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 3 mg/m3 (dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);STEL 10 ppm (vapor) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CAPROLACTAM, dust-air:10H TWA 1 mg/m3;STEL 3 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CAPROLACTAM, vapor-air:10H TWA 0.22 ppm;STEL 0.66 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83732
No. of Facilities: 955 (estimated)
No. of Industries: 14
No. of Occupations: 14
No. of Employees: 6208 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83732
No. of Facilities: 812 (estimated)
No. of Industries: 12
No. of Occupations: 19
No. of Employees: 25091 (estimated)
No. of Female Employees: 8291 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-214,1982
(Research
CAPROLACTONE (EPSILON-)
RTECS NUMBER
: MO8400000
CHEMICAL NAME
: Hexanoic acid, epsilon-lactone
CAS REGISTRY NUMBER
: 502-44-3
BEILSTEIN REFERENCE NO. : 0106919
REFERENCE
: 5-17-09-00034 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C6-H10-O2
MOLECULAR WEIGHT
: 114.16
WISWESSER LINE NOTATION : T7OVTJ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Caprolactone
* epsilon-Caprolactone
* 6-Hexanolactone
* 1,6-Hexanolide
* 6-Hydroxyhexanoic acid lactone
* epsilon-Kaprolakton
* 2-Oxepanone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,911,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5990 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: L5178Y cells in vitro-TK test; E coli
polA without S9
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPRONALDEHYDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MN7175000
Hexanal
66-25-1
0506198
4-01-00-03296 (Beilstein Handbook Reference)
199712
18
C6-H12-O
100.18
VH5
Mutagen
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aldehyde C-6
* Caproaldehyde
* Caproic aldehyde
* Capronaldehyde
* n-Caproylaldehyde
* 1-Hexanal
* Hexanaldehyde
* Hexylaldehyde
* Kapronaldehyd
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/24H
Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,272,1986
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 14178 ug/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,95,1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,272,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4890 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8292 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YKGKAM Yukagaku. Oil Chemistry. (Nippon Yukagaku Kyokai, c/o Yushi
Kogyo
Kaikan, 3-13-11 Nihonbashi, Chuo-ku, Tokyo 103 Japan) V.51956Volume(issue)/page/year: 26,169,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25200 mg/kg/3W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,379,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 33600 ug/kg/28D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 41,515,1988
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 30 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
323,121,1994
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 3 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,277,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
CAPRYLIC ACID ETHYL ESTER
RTECS NUMBER
: RH0680000
CHEMICAL NAME
: Octanoic acid, ethyl ester
CAS REGISTRY NUMBER
: 106-32-1
BEILSTEIN REFERENCE NO. : 1754470
REFERENCE
: 4-02-00-00987 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C10-H20-O2
MOLECULAR WEIGHT
: 172.30
WISWESSER LINE NOTATION : 7VO2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Caprylic acid ethyl ester
* Ethyl caprylate
* Ethyl octanoate
* Ethyl n-octanoate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,763,1976
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,763,1976
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4667
No. of Facilities: 24 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 402 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPRYLIC ACID METHYL ESTER
RTECS NUMBER
: RH0778000
CHEMICAL NAME
: Octanoic acid, methyl ester
CAS REGISTRY NUMBER
: 111-11-5
BEILSTEIN REFERENCE NO. : 1752270
REFERENCE
: 4-02-00-00986 (Beilstein Handbook Reference)
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
SYNONYMS/TRADE NAMES :
* Caprylic acid methyl
* Methyl caprylate
* Methyl octanoate
* Uniphat A20
199710
4
C9-H18-O2
158.27
ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RESJAS Journal of the Reticuloendothelial Society. (1964) (Res: Journal
of
the Reticuloendothelial Society, New York) V.1(1)-14(6), 1964-73.
Volume(issue)/page/year: 3,250,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3714
No. of Facilities: 42 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 382 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CAPTOPRIL
RTECS NUMBER
CHEMICAL NAME
: UY0550000
: 1-Pyrrolidinecarboxylic acid,
1-(D-3-mercapto-2-methyl-1-propionyl)-, L-(S,S)CAS REGISTRY NUMBER
: 62571-86-2
LAST UPDATED
: 199609
DATA ITEMS CITED
: 33
MOLECULAR FORMULA
: C9-H15-N-O3-S
MOLECULAR WEIGHT
: 217.31
WISWESSER LINE NOTATION : T5NTJ AVY1&1SH BVQ
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Capoten
* Captopril
* (-)-Captopril
* L-Captopril
* Captopryl
* 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
* 1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)
* D-3-Mercapto-2-methylpropanoyl-L-proline
* D-3-Mercapto-2-methylpropionylproline
* 1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline
* (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
* D-2-Methyl-3-mercaptopropanoyl-L-proline
* L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (S)* SA 333
* SQ 14,225
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 20,1125,1991
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
28,379,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 4 mg/kg/8D-I
TOXIC EFFECTS :
Behavioral - toxic psychosis
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.781921-
Volume(issue)/page/year: 142,270,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 239 mg/kg/6W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Taste) - change in function
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - normocytic anemia
REFERENCE :
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.11946- Volume(issue)/page/year: 71,493,1981
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2500 ug/kg/3D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased
Kidney, Ureter, Bladder - other changes
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,
POB
88, Oxford, UK) V.11925- Volume(issue)/page/year: 60,561,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2679 ug/kg/5D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,
Israel) V.11965- Volume(issue)/page/year: 21,892,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 7143 ug/kg/2D-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
294,91,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Human - man
12500 ug/kg/25D-I
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
REFERENCE :
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc.,
POB
8650, Ottawa, ON K1G 0G8, Canada) V.11911Volume(issue)/page/year:
129,525,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 14 mg/kg/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
104,126,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1500 ug/kg/7W
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
94,58,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 10 mg/kg/10D-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
294,91,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Human - man
87 mg/kg/18W-I
Kidney, Ureter, Bladder - changes primarily in glomeruli
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - hematuria
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
112,550,1990
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2680 ug/kg/5D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.11908- Volume(issue)/page/year:
86,1269,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 14,297,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 24,2439,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 554 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 14,297,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 22,212,1988
No.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 24,2439,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 663 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 14,297,1983
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >600 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
44XQA7 "Captopril and Hypertension, Collection of Papers presented at a
Symposium, Princeton, N.J., 1979?," Case, David B., et al. eds., New
York,
Plenum Publishing, 1980 Volume(issue)/page/year: -,137,1980
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: >1500 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
44XQA7 "Captopril and Hypertension, Collection of Papers presented at a
Symposium, Princeton, N.J., 1979?," Case, David B., et al. eds., New
York,
Plenum Publishing, 1980
Volume(issue)/page/year: -,137,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 45,15,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg/30D-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Blood - changes in other cell count (unspecified)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 6(Suppl
2),189,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36500 mg/kg/1Y-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 6(Suppl
2),215,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 9100 mg/kg/91D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 6(Suppl
2),247,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 6300 mg/kg/28D-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
44XQA7 "Captopril and Hypertension, Collection of Papers presented at a
Symposium, Princeton, N.J., 1979?," Case, David B., et al. eds., New
York,
Plenum Publishing, 1980 Volume(issue)/page/year: -,137,1980
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE
: 228 mg/kg
SEX/DURATION
: male 43 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - breast development
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
296,1262,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 48 gm/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 13,7041,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 73,221,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 73,221,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 40 mg/kg
SEX/DURATION
: female 15-30 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 170,378,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 8250 ug/kg
SEX/DURATION
: female 24-28 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,1256,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4863
No. of Facilities: 27 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 642 (estimated)
No. of Female Employees: 346 (estimated)
CARBANILIDE
RTECS NUMBER
: FD9800000
CHEMICAL NAME
: Carbanilide
CAS REGISTRY NUMBER
: 102-07-8
BEILSTEIN REFERENCE NO. : 0782650
REFERENCE
: 4-12-00-00741 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C13-H12-N2-O
MOLECULAR WEIGHT
: 212.27
WISWESSER LINE NOTATION : RMVMR
SYNONYMS/TRADE NAMES :
* Acardite
* N,N'-Difenylmocovina
* 1,3-Diphenylcarbamide
* N,N'-Diphenylurea
* s-Diphenylurea
* sym-Diphenylurea
* 1,3-Diphenylurea
* Karbanilid
* Urea, N,N'-diphenyl* Urea, 1,3-diphenyl* USAF EK-534
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 90,260,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBAZOLE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
FE3150000
Carbazole
86-74-8
199710
12
C12-H9-N
167.22
T B656 HMJ
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 9-Azafluorene
* 9H-Carbazole
* Dibenzopyrrole
* Dibenzo(b,d)pyrrole
* Diphenyleneimine
* Diphenylenimide
* Diphenylenimine
* USAF EK-600
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 90,260,1947
V.1-
1909/10-
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)
Volume(issue)/page/year: 46,1859,1993
V.2-5, 1948-52;
V.21- 1968-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25200 mg/kg/12W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 4,291,1979
** MUTATION DATA **
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 504 mg/kg/6W
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 9,387,1988
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,239,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,239,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4468
No. of Facilities: 26 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 78 (estimated)
No. of Female Employees: 52 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CARBENICILLIN DISODIUM
RTECS NUMBER
CHEMICAL NAME
: ON9105000
: Malonamic acid,
N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3
.2.0)hept-6-yl)-2- phenyl-, disodium salt
CAS REGISTRY NUMBER
: 4800-94-6
LAST UPDATED
: 199904
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C17-H16-N2-O6-S.2Na
MOLECULAR WEIGHT
: 422.39
WISWESSER LINE NOTATION : T45 ANV ESTJ CMVYR&VO F1 F1 GVO &-NA- 2
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Anabactyl
* BRL-2064
* Carbecin
* Carbenicillin disodium salt
* Carboxybenzylpenicillin sodium
* CP-15-639-2
* Disodium carbenicillin
* Disodium alpha-carboxybenzylpenicillin
* Fugacillin
* Geopen
* Gripenin
* Hyoper
* Microcillin
*
*
*
*
*
NSC-111071
Piopen
Pyopen
Pyopene
Sodium carbenicillin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,187,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,187,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,187,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,187,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8
Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.11953- Volume(issue)/page/year:
23,572,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,187,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,187,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8
Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.11953- Volume(issue)/page/year:
23,572,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 95500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8
Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.11953- Volume(issue)/page/year:
17,1111,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 9800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 34,405,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3871
No. of Facilities: 385 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 13162 (estimated)
No. of Female Employees: 8667 (estimated)
CARBIDOPA
RTECS NUMBER
CHEMICAL NAME
: MW5298000
: Hydrocinnamic acid,
alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, LCAS REGISTRY NUMBER
: 28860-95-9
LAST UPDATED
: 199504
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C10-H14-N2-O4
MOLECULAR WEIGHT
: 226.26
WISWESSER LINE NOTATION : ZMX1&VQ1R CQ DQ
COMPOUND DESCRIPTOR
: Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* N-Aminomethyldopa
* Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-,
(S)* Carbidopa
* Hydrazino-alpha-methyldopa
* alpha-Methyldopahydrazine
* L-alpha-Methyldopahydrazine
* MK 486
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2804 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan)
V.1-
1950-
Volume(issue)/page/year: 31,1127,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 468 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,1127,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23400 mg/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
66,201,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2100 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,251,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2880 mg/kg
SEX/DURATION
: female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
66,201,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/plate
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 49,415,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4821
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 303 (estimated)
No. of Female Employees: 166 (estimated)
CARBOBENZYLOXYGLYCINE
RTECS NUMBER
: MB9129000
CHEMICAL NAME
: Glycine, N-carboxy-, N-benzyl ester
CAS REGISTRY NUMBER
: 1138-80-3
BEILSTEIN REFERENCE NO. : 0526877
REFERENCE
: 4-06-00-02286 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C10-H11-N-O4
MOLECULAR WEIGHT
: 209.22
WISWESSER LINE NOTATION : QVN1R&1VQ
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzyloxycarbonylglycine
* N-Benzyloxycarbonylglycine
* Carbobenzoxyglycine
* N-Carbobenzoxyglycine
* Carbobenzoxyl glycine
* Carbobenzyloxyglycine
* N-Carbobenzyloxyglycine
* (Cbz)gly
* Glycine, N-((phenylmethoxy)carbonyl)* N-((Phenylmethoxy)carbonyl)glycine
* Z-Gly
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intravaginal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 68,696,1979
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 280 mg/kg
SEX/DURATION
: female 28 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 70,60,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 280 mg/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 70,60,1981
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBOETHOXYPHTHALIMIDE (N-)
RTECS NUMBER
: NR3459500
CHEMICAL NAME
: 2-Isoindolinecarboxylic acid, 1,3-dioxo-, ethyl
ester
CAS REGISTRY NUMBER
: 22509-74-6
BEILSTEIN REFERENCE NO. : 0196340
REFERENCE
: 5-21-10-00428 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C11-H9-N-O4
MOLECULAR WEIGHT
: 219.21
WISWESSER LINE NOTATION : T56 BVNVJ CVO2
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* N-Carbethoxyphthalimide
* N-Carboethoxyphthalimide
* N-(Ethoxycarbonyl)phthalimide
* Ethyl N-phthaloylcarbamate
* 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, ethyl ester
* N-Karbetoksi-ftalimid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb,
Yugoslavia) V.1-41, 1951-91. For publisher information, see ACPHEE
Volume(issue)/page/year: 6,27,1956
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBOHYDRAZIDE
RTECS NUMBER
: FF2625000
CHEMICAL NAME
: Carbohydrazide
CAS REGISTRY NUMBER
: 497-18-7
BEILSTEIN REFERENCE NO. : 1747069
REFERENCE
: 4-03-00-00240 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C-H6-N4-O
MOLECULAR WEIGHT
: 90.11
WISWESSER LINE NOTATION : ZMVMZ
SYNONYMS/TRADE NAMES :
* Carbazic acid, hydrazide
* Carbodihydrazide
* Carbonic acid, dihydrazide
* Carbonic dihydrazide
* Carbonohydrazide
* 1,3-Diaminomocovina
*
*
*
*
*
1,3-Diaminourea
Hydrazine, carbonyldiKarbazid
Semicarbazide, 4-aminoUrea, 1,3-diamino*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 167 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - monoamine oxidase
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington,
DC)
V.1-5, 1959-62. For publisher information, see JMCMAR.
Volume(issue)/page/year: 4,259,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
21,635,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 122,110,1958
V.1-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82784
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 42 (estimated)
1909/10-
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82784
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1822 (estimated)
No. of Female Employees: 272 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBON DIOXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
FF6400000
Carbon dioxide
124-38-9
199907
49
C-O2
44.01
C
O2
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Anhydride carbonique
* Carbon dioxide
* Carbonic acid anhydride
* Carbonic acid gas
* Carbonic anhydride
* Carbon oxide
* Dry ice
* Khladon 744
* Kohlendioxyd
* Kohlensaure
* R 744
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 9 pph/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
ROUTE OF EXPOSURE
: LCLo - Lowest published lethal concentration
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 90000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10000 ppm/24H/30D-C
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 78,11,1943
V.1-
1909/10-
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 27000 ppm/24H/30D-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 78,11,1943
V.1-
1909/10-
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6 pph/24H
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
CIRUAL Circulation Research. (American Heart Assoc., 7320 Greenville
Ave.,
Dallas, TX 75231) V.11953- Volume(issue)/page/year: 8,1218,1960
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
6 pph/24H
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
CIRUAL Circulation Research. (American Heart Assoc., 7320 Greenville
Ave.,
Dallas, TX 75231) V.11953- Volume(issue)/page/year: 8,1218,1960
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 55 pph/2H
SEX/DURATION
: male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 13,165,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 55 pph/4H
SEX/DURATION
: male 6 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 13,165,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 pph/8H
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 30,187,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 13 pph/4H
SEX/DURATION
: female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ZMOAAN Zeitschrift fuer Morphologie und Anthropologie. (E.
Schweizerbart'sche Verlagsbuchhandlung, Johannesstr. 3A, D-7000 Stuttgart
1,
Fed. Rep. Ger.) V.11899- Volume(issue)/page/year: 56,165,1965
*** REVIEWS ***
ACGIH TLV-STEL 54000 mg/m3 (30000 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 9000 mg/m3 (5000 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,163,1975
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 5000 ppm (9000 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,39,1971
OSHA PEL (Gen Indu):8H TWA 5000 ppm (9000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5000 ppm (9000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5000 ppm (9000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5000 ppm (9000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5000 ppm (9000 mg/m3);STEL 30000 ppm JAN 1993
OEL-AUSTRIA: MAK 5000 ppm (9000 mg/m3), JAN1999
OEL-BELGIUM:TWA 5000 ppm (9000 mg/m3);STEL 30000 ppm JAN 1993
OEL-DENMARK: TWA 5000 ppm (9000 mg/m3), JAN1999
OEL-FINLAND:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-GERMANY:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-JAPAN: OEL 5000 ppm (9000 mg/m3), JAN1999
OEL-HUNGARY:STEL 9000 mg/m3 JAN 1993
OEL-JAPAN:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 9000 mg/m3, MAC(STEL) 27000 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-SWEDEN: NGV 5000 ppm (9000 mg/m3), KTV 10000 ppm (18000 mg/m3),
JAN1999
OEL-RUSSIA:TWA 5000 ppm JAN 1993
OEL-SWEDEN:TWA 5000 ppm (9000 mg/m3);STEL 10000 ppm JAN 1993
OEL-SWITZERLAND:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-THAILAND:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-TURKEY:TWA 5000 ppm (9000 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 5000 ppm (9000 mg/m3);STEL 15000 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CARBON DIOXIDE-air:10H TWA 5000 ppm;STEL 30000 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 17367
No. of Facilities: 35989 (estimated)
No. of Industries: 239
No. of Occupations: 150
No. of Employees: 447416 (estimated)
NOES - National Occupational
NOES Hazard Code - X8532
No. of Facilities: 12913
No. of Industries: 110
No. of Occupations: 95
No. of Employees: 192401
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
17538 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 17367
No. of Facilities: 70119 (estimated)
No. of Industries: 310
No. of Occupations: 186
No. of Employees: 1121046 (estimated)
No. of Female Employees: 222613 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Carbon dioxide, 6603
OSHA ANALYTICAL METHOD #ID-172
CARBON DISULFIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
FF6650000
Carbon disulfide
75-15-0
1098293
4-03-00-00395 (Beilstein Handbook Reference)
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
199907
84
C-S2
76.13
C
S2
Agricultural Chemical
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Carbon bisulfide
* Carbon bisulphide
* Carbon disulfide
* Carbon disulphide
* Carbone (sufure de)
* Carbonio (solfuro di)
* Dithiocarbonic anhydride
* Kohlendisulfid (schwefelkohlenstoff)
* Koolstofdisulfide (zwavelkoolstof)
* NCI-C04591
* RCRA waste number P022
* Schwefelkohlenstoff
* Solfuro di carbonio
* Sulphocarbonic anhydride
* Weeviltox
* Wegla dwusiarczek
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 4000 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH,
Chemical Rubber Co., 1968 Volume(issue)/page/year: -,118,1968
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 186 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >505 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233,
Berlin DDR-1086, Ger. Dem. Rep.) V.421983Volume(issue)/page/year:
49,121,1990
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,32,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(1),13,1966
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,32,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rabbit
(V/O
DOSE/DURATION
: 2550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(1),13,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(1),13,1966
(V/O
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Liver - fatty liver degeneration
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
35,21,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5055 mg/kg/4W-I
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Cardiac - pulse rate
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233,
Berlin DDR-1086, Ger. Dem. Rep.) V.421983Volume(issue)/page/year:
49,121,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/m3/5H/13W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Endocrine - other changes
Biochemical - Neurotransmitters or modulators (putative) - dopamine at
other
sites
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
25,339,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2000 ppm/4H/2W-I
TOXIC EFFECTS :
Behavioral - changes in psychophysiological tests
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
25,369,1964
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 114 mg/m3/8H/20W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - changes in spleen
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 18,733,1936
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 ppm/6H/12W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
94,356,1988
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/m3/5H/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,139,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/m3/5H/1Y-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,139,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/m3/17W-I
TOXIC EFFECTS :
Cardiac - changes in coronary arteries
Vascular - structural changes in vessels
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 15,3,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/24H/25W-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from afferent nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
34,175,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 ppm/6H/15W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
66,334,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg/3D-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 8,245,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5512 mg/kg/5D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 47,479,1996
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 114 mg/m3/8H/20W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 18,733,1936
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1250 mg/m3/8H/11W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,415,1941
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1200 mg/m3/6H/20W-I
TOXIC EFFECTS :
Endocrine - hyperglycemia
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 29,151,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 160 ppm/6H/36D
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 3,63,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 25298 mg/kg/26W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Endocrine - hyperglycemia
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(1),13,1966
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE
: 40 mg/m3
SEX/DURATION
: male 91 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8,
20122
Milan, Italy) V.161925- Volume(issue)/page/year: 60,566,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 4,86,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/m3/24H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
21,257,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 mg/m3/8H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,252,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/m3/8H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
2,129,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
100 mg/m3/8H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 14,374,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 ug/m3/8H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,252,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 600 ppm/6H
SEX/DURATION
: male 50 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
73,275,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2000 mg/m3/2H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 68,1158,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 350 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 4,86,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2100 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 4,86,1984
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 uL/plate
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: 5AUG1977
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 8 mg/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
10,21,1990
(Alan R. Liss,
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10200 ug/L
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 14,115,1981
*** REVIEWS ***
ACGIH TLV-TWA 31 mg/m3 (10 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AHJOA2 American Heart Journal.
Industrial
Dr., St. Louis, MO 63146) V.183,100,1972
(C.V. Mosby Co., 11830 Westline
1925-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
2,365,1973
TOXICOLOGY REVIEW
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
35,55,1974
TOXICOLOGY REVIEW
KHZDAN Khigiena i Zdraveopazvane.
Russki 6, Sofia, Bulgaria) V.916,208,1973
Hygiene and Sanitation. (Hemus, Blvd.
1966- Volume(issue)/page/year:
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 20 ppm (60 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,39,1971
OSHA PEL (Gen Indu):8H TWA 20 ppm;CL 30 ppm;Pk 100 ppm/30M/8H
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 20 ppm (60 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 20 ppm (60 mg/m3) (skin)
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 20 ppm (60 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 10 ppm (30 mg/m3);Skin JAN 1993
OEL-AUSTRALIA:TWA 10 ppm (30 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 10 ppm (31 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 5 ppm (15 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3);Skin JAN 1993
OEL-JAPAN: OEL 10 ppm (31 mg/m3), Skin, JAN1999
OEL-GERMANY:TWA 10 ppm (30 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 18 mg/m3, MAC(STEL) 30 mg/m3, JAN1999
OEL-INDIA:TWA 10 ppm (30 mg/m3);Skin JAN 1993
OEL-JAPAN:TWA 10 ppm (31 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 20 ppm (60 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 20 ppm (60 mg/m3);Skin JAN 1993
OEL-RUSSIA:TWA 10 ppm;STEL 1 mg/m3 JAN 1993
OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 8 ppm (25 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm;Skin JAN 1993
OEL-THAILAND:TWA 20 ppm (60 mg/m3);STEL 30 ppm (90 mg/m3) JAN 1993
OEL-TURKEY:TWA 10 ppm (65 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CARBON DISULFIDE-air:10H TWA 1 ppm (Sk);STEL 10 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 17370
No. of Facilities: 1074 (estimated)
No. of Industries: 24
No. of Occupations: 27
No. of Employees: 24200 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 17370
No. of Facilities: 751 (estimated)
No. of Industries: 20
No. of Occupations: 44
No. of Employees: 45760 (estimated)
No. of Female Employees: 5834 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0393-8888
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Carbon disulfide, 1600
CARBON LAMPBLACK
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Acetylene Black
* Aroflow
* Arogen
:
:
:
:
:
:
FF5800000
Carbon Black
1333-86-4
199907
37
Tumorigen
Mutagen
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Arotone
Arovel
Arrow
Atlantic
Black pearls
Cancarb
Carbodis
Carbolac
Carbolac 1
Carbomet
Carbon Black
Carbon black, acetylene
Carbon Black BV and V
Carbon black, channel
Carbon black, furnace
Carbon black, lamp
Carbon black, thermal
Channel Black
C.I. 77266
C.I. Pigment Black 6
C.I. Pigment Black 7
CK3
Collocarb
Columbia carbon
Conductex 900
Continex
Corax A
Corax P
Croflex
Crolac
Degussa
Delussa Black FW
Durex O
Eagle Germantown
ELF 78
Elftex
Essex
Excelsior
Explosion Black
Explosion Acetylene Black
Farbruss
Fecto
Flamruss
Furnal
Furnex
Furnex N 765
Gas-furnace black
Gastex
Huber
Humenegro
Impingement Black
Ketjenblack EC
Kosmink
Kosmobil
Kosmolak
Kosmos
Kosmotherm
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Kosmovar
Magecol
Metanex
Micronex
Miike 20
Modulex
Mogul
Mogul L
Molacco
Monarch 1300
Neo Spectra Beads AG
Neo-Spectra Mark II
Neotex
Oil-furnace Black
P 33 (carbon black)
P68
P1250
Peach black
Pelletex
Philblack
Philblack N 550
Philblack N 765
Philblack O
Pigment Black 7
Printex
Printex 60
Raven
Raven 30
Raven 420
Raven 500
Raven 8000
Rebonex
Regal
Regal 99
Regal 300
Regal 330
Regal 600
Regal 400R
Regal SRF
Regent
Royal spectra
Sevacarb
Seval
Shawinigan Acetylene Black
Shell carbon
Special Black 1V & V
Special schwarz
Spheron
Spheron 6
Statex
Statex N 550
Sterling MT
Sterling N 765
Sterling NS
Sterling SO 1
Superba
Super-carbovar
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Super-spectra
Texas
Therma-atomic Black
Thermal Acetylene Black
Thermatomic
Thermax
Thermblack
Tinolite
TM 30
Toka Black 4500
Toka Black 5500
Toka Black 8500
Torch Brand
Ucet
Ukarb
United
Velvetex
Vulcan
Witco
Witcoblak No. 100
Wyex
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >15400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 15(Suppl 1),S28,1996
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 15(Suppl 1),S28,1996
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - rat
DOSE/DURATION
: 50 mg/m3/6H/90D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 15,46,1995
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11600 ug/m3/18H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.11989Volume(issue)/page/year: 7,533,1995
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/plate
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring
St.,
New York, NY 10013) V.11972- Volume(issue)/page/year: 27,297,1983
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 6200 ug/m3/16H/12W (Intermittent)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
16,64,1990
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 3.5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 65,149,1996
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 33,35,1984
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 33,35,1984
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 65,149,1996
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 65,149,1996
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 3.5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,38,1971
OSHA PEL (Gen Indu):8H TWA 3.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 3.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 3.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 3.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 3 mg/m3 JAN 1993
OEL-BELGIUM:TWA 3.5 mg/m3 JAN 1993
OEL-DENMARK: TWA 3.5 mg/m3, JAN1999
OEL-FINLAND:TWA 3.5 mg/m3;STEL 7 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 3.5 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 3.5 mg/m3 JAN 1993
OEL-RUSSIA:STEL 4 mg/m3 JAN 1993
OEL-SWEDEN:TWA 3 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 3.5 mg/m3;STEL 7 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CARBON BLACK-air:10H CA TWA 3.5 mg/m3 in pres. of PAHs
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0647
No. of Facilities: 19312 (estimated)
No. of Industries: 159
No. of Occupations: 88
No. of Employees: 172738 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0647
No. of Facilities: 108610 (estimated)
No. of Industries: 376
No. of Occupations: 206
No. of Employees: 1728518 (estimated)
No. of Female Employees: 369253 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7126
No. of Facilities: 22 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 129 (estimated)
No. of Female Employees: 65 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Carbon black, 5000
CARBON MONOXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
FG3500000
Carbon monoxide
630-08-0
199907
79
C-O
28.01
C
O
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Carbone (oxyde de)
* Carbonic oxide
* Carbonio (ossido di)
* Carbon monoxide
* Carbon oxide (CO)
* Exhaust gas
* Flue gas
* Kohlenmonoxid
* Kohlenoxyd
* Koolmonoxyde
* Oxyde de carbone
* Wegla tlenek
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 600 mg/m3/10M
TOXIC EFFECTS :
Behavioral - headache
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(4),34,1987
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 4000 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH,
Chemical Rubber Co., 1968 Volume(issue)/page/year: -,207,1968
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 650 ppm/45M
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
Behavioral - changes in psychophysiological tests
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,212,1973
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 5000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1807 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,752,1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - mouse
2444 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,752,1970
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4000 ppm/46M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1360,1935
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1360,1935
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5718 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,752,1970
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 5000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 1334 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 12,355,1983
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1800 ppm/1H/14D-I
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 15,366,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 mg/m3/8H/10W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 26(3),3,1961
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 96 ppm/24H/90D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,46,1971
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ppm/5H/20D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in other cell count (unspecified)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094)
V.1-
1966-
Volume(issue)/page/year: 13,537,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5983 mg/kg/18W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
1,275,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 200 ppm/24H/90D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,46,1971
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/m3/3H/13W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Cardiac - other changes
Blood - hemorrhage
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 24(6),22,1959
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ppm/24H/8W-C
TOXIC EFFECTS :
Blood - changes in platelet count
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 4(1),351,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/m3/5H/4W-I
TOXIC EFFECTS :
Endocrine - hyperglycemia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
Volume(issue)/page/year: 30(5),30,1965
V.1-
1936-
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/m3/5H/30W-I
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Cardiac - EKG changes not diagnostic of specified effects
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(3),102,1966
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 ppm/24H/90D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,46,1971
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 ppm/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
56,370,1980
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
weight
gain)
Reproductive - Effects
REFERENCE :
NETOD7 Neurobehavioral
For
publisher information,
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
150 ppm/24H
female 1-22 day(s) after conception
on Newborn - growth statistics (e.g.%, reduced
on Newborn - behavioral
Toxicology.
(Fayetteville, NY)
V.1-2, 1979-80.
see NTOTDY.
Volume(issue)/page/year: 2,7,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/m3/24H
SEX/DURATION
: female 72 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Maternal Effects - parturition
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
35(4-6),277,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 ppm/24H
SEX/DURATION
: female 0-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
59,1553,1996
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 75 ppm/24H
SEX/DURATION
: female 0-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 73,274,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 65 ppm/24H
SEX/DURATION
: female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(2),8B,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 250 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,385,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 125 ppm/24H
SEX/DURATION
: female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 30,253,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 8 pph/1H
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
FPNJAG Folia Psychiatrica et Neurologica Japonica. (Folia Pub. Soc.,
Todai
YMCA Bldg., 1-20-6 Mukogaoka, Bunkyo-Ku, Tokyo 113, Japan) V.11933Volume(issue)/page/year: 11,301,1958
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 8 pph/1H
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
FPNJAG Folia Psychiatrica et Neurologica Japonica. (Folia Pub. Soc.,
Todai
YMCA Bldg., 1-20-6 Mukogaoka, Bunkyo-Ku, Tokyo 113, Japan) V.11933Volume(issue)/page/year: 11,301,1958
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 180 ppm/24H
SEX/DURATION
: female 1-30 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK)
Volume(issue)/page/year: 2,1220,1972
V.1-
1823-
** MUTATION DATA **
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1500 ppm/10M
REFERENCE :
YOMJA9 Yonsei Medical Journal. (Yonsei Univ. College of Medicine, P.O.
Box
71, Seoul, S. Korea) V.11960- Volume(issue)/page/year: 27,205,1986
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2500 ppm/10M
REFERENCE :
YOMJA9 Yonsei Medical Journal. (Yonsei Univ. College of Medicine, P.O.
Box
71, Seoul, S. Korea) V.11960- Volume(issue)/page/year: 27,205,1986
*** REVIEWS ***
ACGIH TLV-TWA 29 mg/m3 (25 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 10,236,1975
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,163,1975
TOXICOLOGY REVIEW
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
17,143,1974
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.11955Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
1946-
Volume(issue)/page/year: 38,409,1965
(Lausanne, Switzerland)
V.1-11, 1972-78. For
pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
17,159,1974
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-691001
TOXICOLOGY REVIEW
BPAAAG Beitraege zur Pathologischen Anatomie und Allgemeinen Pathologie.
(Stuttgart, Fed. Rep. Ger.) V.3-140, 1888-1970. For publisher
information,
see PARPDS. Volume(issue)/page/year: 135,350,1967
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 50 ppm (55 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,41,1971
OSHA PEL (Gen Indu):8H TWA 50 ppm (55 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 50 ppm (55 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 50 ppm (55 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 50 ppm (55 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 50 ppm (55 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 30 ppm (33 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 50 ppm (55 mg/m3);STEL 400 ppm (440 mg/m3) JAN 1993
OEL-BELGIUM:TWA 50 ppm (57 mg/m3);STEL 400 ppm (458 mg/m3) JAN 1993
OEL-DENMARK: TWA 35 ppm (40 mg/m3), JAN1999
OEL-FINLAND:TWA 30 ppm (34 mg/m3);STEL 75 ppm (86 mg/m3) JAN 1993
OEL-JAPAN: OEL 50 ppm (57 mg/m3), JAN1999
OEL-GERMANY:TWA 30 ppm (33 mg/m3) JAN 1993
OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 30 mg/m3, MAC(STEL) 180 mg/m3, JAN1999
OEL-INDIA:TWA 50 ppm (55 mg/m3);STEL 400 ppm (440 mg/m3) JAN 1993
OEL-JAPAN:TWA 50 ppm (57 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 25 ppm (29 mg/m3);STEL 120 ppm JAN 1993
OEL-THE PHILIPPINES:TWA 50 ppm (55 mg/m3) JAN 1993
OEL-RUSSIA:TWA 50 ppm;STEL 20 mg/m3 JAN 1993
OEL-SWEDEN:TWA 35 ppm (40 mg/m3);STEL 100 ppm (120 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 30 ppm (35 mg/m3);STEL 60 ppm (66 mg/m3) JAN 1993
OEL-THAILAND:TWA 50 ppm (55 mg/m3) JAN 1993
OEL-TURKEY:TWA 50 ppm (55 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (55 mg/m3);STEL 300 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CARBON MONOXIDE-air:8H TWA 35 ppm;CL 200 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 17460
No. of Facilities: 2593 (estimated)
No. of Industries: 43
No. of Occupations: 68
No. of Employees: 32958 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 17460
No. of Facilities: 1950 (estimated)
No. of Industries: 24
No. of Occupations: 52
No. of Employees: 68434 (estimated)
No. of Female Employees: 7860 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1996: Carbon monoxide, 6604
CARBON TETRABROMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
:
FG4725000
Carbon tetrabromide
558-13-4
1732799
4-01-00-00085 (Beilstein Handbook Reference)
199907
18
C-Br4
331.65
EXEEE
*
*
*
*
*
*
Bromid uhlicity
Carbon bromide
Carbon tetrabromide
Methane, tetrabromide
Methane, tetrabromoTetrabromomethane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 298 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,354,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#01612
*** REVIEWS ***
ACGIH TLV-STEL 4.1 mg/m3 (0.3 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1.4 mg/m3 (0.1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 ppm (1.4 mg/m3);STEL 0.3 ppm (4 mg/m3) JAN 1993
OEL-BELGIUM:TWA 0.1 ppm (1.4 mg/m3);STEL 0.3 ppm (4.1 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.1 ppm (1.4 mg/m3), JAN1999
OEL-FINLAND:TWA 0.1 ppm (1.4 mg/m3);STEL 0.4 ppm;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (1.4 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (1.4 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 ppm (1.4 mg/m3);STEL 0.3 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CARBON TETRABROMIDE-air:10H TWA 0.1 ppm;STEL 0.3 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4014
No. of Facilities: 34 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 2703 (estimated)
No. of Female Employees: 459 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CARBON TETRACHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
FG4900000
Carbon tetrachloride
56-23-5
199907
166
C-Cl4
153.81
GXGGG
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzinoform
* Carbona
* Carbon chloride (CCl4)
* Carbon TET
* Carbon tetrachloride
* Chlorid uhlicity
* Czterochlorek wegla
* ENT 4,705
* ENT 27164
* Flukoids
* Halon 1040
* Methane tetrachloride
* Methane, tetrachloro* Necatorina
* Perchloromethane
* R 10
* RCRA waste number U211
* R 10 (Refrigerant)
* Tetrachloorkoolstof
* Tetrachloormetaan
* Tetrachlorkohlenstoff, tetra
* Tetrachlormethan
* Tetrachlorocarbon
* Tetrachloromethane
* Tetrachlorure de carbone
* Tetraclorometano
* Tetracloruro di carbonio
* Tetrafinol
* Tetraform
* Tetrasol
* Univerm
* Vermoestricid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4 mg
REACTION SEVERITY
: Mild
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research
and
Development Reports. (Rochester, NY) Volume(issue)/page/year: MDDC-1715
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/24H
Mild
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,91,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2200 ug/30S
REACTION SEVERITY
: Mild
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research
and
Development Reports. (Rochester, NY) Volume(issue)/page/year: MDDC-1715
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,91,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 20 ppm
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
85CYAB "Chemistry of Industrial Toxicology," 2nd ed., Elkins, H.B., New
York, John Wiley & Sons, Inc., 1959 Volume(issue)/page/year: 2,136,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - coma
Behavioral - antipsychotic
REFERENCE :
TXMDAX Texas Medicine. (Texas Medical Assoc., 1801 N. Lamar Blvd.,
Austin,
TX 78701) V.601964- Volume(issue)/page/year: 69,86,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - other changes
REFERENCE :
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,
Secy., P.O. Box 643, Cape Town, S. Africa) V.61932Volume(issue)/page/year: 49,635,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 429 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate
Lungs, Thorax, or Respiration - cyanosis
Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 19,781,1973
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,198,1966
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 45 ppm/3D
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - anorexia (human)
Gastrointestinal - nausea or vomiting
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,360,1960
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 317 ppm/30M
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
103,962,1934
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LCLo - Lowest published lethal concentration
Inhalation
Human
5 pph/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
54,275,1983
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,16,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,16,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 1500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research
and
Development Reports. (Rochester, NY) Volume(issue)/page/year: MDDC-1715
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520615
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8263 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 3,169,1951
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9526 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,382,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 572 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental
Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.11959Volume(issue)/page/year: 10,172,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
31 gm/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 123,224,1958
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 14620 ppm/8H
TOXIC EFFECTS :
Behavioral - general anesthetic
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
Volume(issue)/page/year: 191,1,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,119,1967
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 38110 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1405,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - fatty liver degeneration
Blood - hemorrhage
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 63,153,1938
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(1),32,1968
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,712,1992
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 477 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GASTAB Gastroenterology.
(Academic Press, Inc., 1 E. First St., Duluth,
MN
55802)
V.1-
1943-
Volume(issue)/page/year: 71,118,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5840 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZAPPAN Zentralblatt fuer Allgemeine Pathologie und Pathologische
Anatomie.
(VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)
V.11890- Volume(issue)/page/year: 118,305,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(1),32,1968
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 20000 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.11967- Volume(issue)/page/year: 1,197,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - guinea pig
>9400 uL/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,559,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 4497 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
Gastrointestinal - other changes
REFERENCE :
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue,
Eastbourne BN21 3UN, UK) V.1051949- Volume(issue)/page/year:
127,304,1971
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 58 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 97,86,1923
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 34500 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 24(3),17,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/kg/12W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 15,558,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4197 ug/kg/28D-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 3,169,1951
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg/10D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 17,186,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 41 mg/m3/4H/8D-I
TOXIC EFFECTS :
Endocrine - evidence of thyroid hypofunction
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 12,5,1971
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 61 mg/m3/90D-C
TOXIC EFFECTS :
Liver - fatty liver degeneration
Liver - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppm/1H/46D-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,50,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ppm/7H/27W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,50,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 ppm/3H/8W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
11,48,1973
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppm/8H/46W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 18,277,1936
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 31200 uL/kg/12W-I
TOXIC EFFECTS :
Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 85,275,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8750 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 7,454,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1080 mg/kg/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 7,454,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 636 gm/kg/16D-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Blood - change in clotting factors
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 22,215,1923
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
V.1-
1909/10-
: TCLo - Lowest published toxic concentration
: Inhalation
: Mammal - dog
DOSE/DURATION
: 515 mg/m3/8H/6W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 515 mg/m3/8H/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis (interstitial)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 61 mg/m3/90D-C
TOXIC EFFECTS :
Liver - other changes
Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 200 ppm/8H/46W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 18,277,1936
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 515 mg/m3/8H/6W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 61 mg/m3/90D-C
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ppm/7H/30W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,50,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/m3/3H/35W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Kidney, Ureter, Bladder - other changes in urine composition
Immunological Including Allergic - decreased immune response
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(5),47,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 515 mg/m3/8H/6W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 61 mg/m3/90D-C
TOXIC EFFECTS :
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.110,270,1967
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 ppm/7H/33W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,50,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 25 ppm/8H/46W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
Endocrine - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 18,277,1936
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15600 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
38,891,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4400 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
20,431,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 305 gm/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 89,845,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 9250 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
26,855,1961
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 gm/kg/88D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
4,385,1944
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 gm/kg/25W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
KRMJAC Kurume Medical Journal. (Kurume Univ. School of Medicine, Dept.
of
Physiology, 67, Asahi- machi, Kurume 830, Japan) V.11954Volume(issue)/page/year: 12,37,1965
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 31 gm/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
45,1237,1970
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 182 gm/kg/70W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
44,419,1970
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8580 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
4,385,1944
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 57600 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
2,197,1941
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: female 7-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis,
H.,
Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 gm/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 82,1262,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 56,252,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 750 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 40,30,1997
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,452,1974
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
250 ppm/8H
female 10-15 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.301969- Volume(issue)/page/year: 32,2021,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 71500 mg/kg
SEX/DURATION
: male 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 22,395,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 gm/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 10,39,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2384 mg/kg
SEX/DURATION
: female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 76,1467,1973
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 20 uL/L
REFERENCE :
EJMBA2 Egyptian Journal of Microbiology. (National Information and
Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)
V.71972- Volume(issue)/page/year: 18,213,1983
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 12500 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 300 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 200 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 2 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
397,271,1998
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 5000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,288,1985
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 5000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,288,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 5000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,288,1985
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 367 umol/kg
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 11,419,1973
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 31 gm/kg/12W (Intermittent)
REFERENCE :
FHCYAI Folia Histochemica et Cytochemica. (Cracow, Poland)
1963-83. Volume(issue)/page/year: 13,207,1975
V.1-21,
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 mmol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Mutation test systems - not otherwise specified
Intraperitoneal
Rodent - rat
100 mg/kg
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
35,191,1987
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
35,191,1987
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,189,1994
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
344,109,1995
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 31 gm/kg/12W (Intermittent)
REFERENCE :
FHCYAI Folia Histochemica et Cytochemica. (Cracow, Poland)
1963-83. Volume(issue)/page/year: 13,207,1975
V.1-21,
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 367 umol/kg
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 11,419,1973
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 10 umol
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,81,1983
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 335 umol/kg
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 175,237,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 6550 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,155,1988
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,474,1984
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 500 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,291,1983
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1600 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,135,1987
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.111,243,1982
1977-
Volume(issue)/page/year:
*** REVIEWS ***
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 63 mg/m3 (10 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 31 mg/m3 (5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,371,1979
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,53,1972
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,53,1972
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,371,1979
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,143,1987
TOXICOLOGY REVIEW
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 24,173,1974
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
TOXICOLOGY REVIEW
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.11949- Volume(issue)/page/year: 4,1,1952
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,250,1970
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
7,177,1980
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 6,1133,1980
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB256-732
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 10 ppm (65 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,43,1971
OSHA PEL (Gen Indu):8H TWA 10 ppm;CL 25 ppm;Pk 200 ppm/5M/4H
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 10 ppm (65 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 10 ppm (65 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 10 ppm (65 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 5 ppm (30 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 10 ppm (65 mg/m3), Skin, Suspected Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 5 ppm (30 mg/m3);Skin;Carcinogen JAN 1993
OEL-BELGIUM:TWA 5 ppm (31 mg/m3);Skin;Carcinogen JAN 1993
OEL-DENMARK: TWA 2 ppm (13 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 5 ppm (31 mg/m3);STEL 10 ppm (63 mg/m3);Skin;Carcinogen
JAN
1993
OEL-JAPAN: OEL 5 ppm (31 mg/m3), Skin, 2B Carcinogen, JAN1999
OEL-GERMANY:TWA 10 ppm (65 mg/m3);Skin;Carcinogen JAN 1993
OEL-HUNGARY:STEL 10 mg/m3;Skin;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 20 mg/m3, MAC(STEL) 100 mg/m3, JAN1999
OEL-INDIA:TWA 5 ppm (30 mg/m3);Skin;Carcinogen JAN 1993
OEL-JAPAN:TWA 10 ppm (63 mg/m3);Skin;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 2 ppm (12.6 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (65 mg/m3);Skin JAN 1993
OEL-RUSSIA:TWA 10 ppm;STEL 20 mg/m3 JAN 1993
OEL-SWEDEN:TWA 2 ppm (13 mg/m3);STEL 3 ppm (19 mg/m3);Skin;Carcinogen JAN
1993
OEL-SWITZERLAND:TWA 5 ppm (30 mg/m3);STEL 10 ppm (60 mg/m3);Skin JAN 1993
OEL-THAILAND:TWA 10 ppm;STEL 25 ppm JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (65 mg/m3);STEL 20 ppm;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CARBON TETRACHLORIDE-air:CA STEL 2 ppm/60M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 17490
No. of Facilities: 5152 (estimated)
No. of Industries: 73
No. of Occupations: 56
No. of Employees: 64009 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 17490
No. of Facilities: 6629 (estimated)
No. of Industries: 77
No. of Occupations: 72
No. of Employees: 104174 (estimated)
No. of Female Employees: 20699 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/168196/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; S
cerevisiae
gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis; S
cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm
morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
CARBONYL IRON
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
NO4565500
Iron
7439-89-6
199812
18
Fe
55.85
Tumorigen
Human
SYNONYMS/TRADE NAMES :
* Ancor en 80/150
* Armco iron
* Carbonyl iron
* EFV 250/400
* EO 5A
* Ferrovac E
* GS 6
* LOHA
* NC 100
* PZh2M
* PZhO
* Remko
* SUY-B 2
* 3ZhP
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 77 mg/kg
TOXIC EFFECTS :
Behavioral - irritability
Gastrointestinal - nausea or vomiting
Blood - normocytic anemia
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology.
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
25,251,1987
(Marcel Dekker, 270
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 gm/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78.
For
publisher information, see IJSIDW. Volume(issue)/page/year: 13,240,1951
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB158-508
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 20 gm/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78.
For
publisher information, see IJSIDW. Volume(issue)/page/year: 13,240,1951
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 63 gm/kg/6W-C
TOXIC EFFECTS :
Liver - other changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 124,73,1997
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/m3/6H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
145,10,1997
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 450 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 16,380,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 91095
No. of Facilities: 13096 (estimated)
No. of Industries: 160
No. of Occupations: 115
No. of Employees: 207672 (estimated)
NOES - National Occupational
NOES Hazard Code - T0176
No. of Facilities: 13865
No. of Industries: 130
No. of Occupations: 72
No. of Employees: 204603
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
16574 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3724
No. of Facilities: 122 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1670 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5910
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 400 (estimated)
No. of Female Employees: 400 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5996
No. of Facilities: 45 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 179 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 91095
No. of Facilities: 103949 (estimated)
No. of Industries: 364
No. of Occupations: 174
No. of Employees: 1312446 (estimated)
No. of Female Employees: 116899 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Metals in urine, 8310
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
CARBOPOL
RTECS NUMBER
: AT4680000
CHEMICAL NAME
: Acrylic acid, polymers
CAS REGISTRY NUMBER
: 9003-01-4
OTHER CAS REGISTRY NOS. : 51142-25-7
LAST UPDATED
: 199710
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: (C3-H4-O2)x
MOLECULAR WEIGHT
: 168.06
WISWESSER LINE NOTATION : /*1Y*VQ/
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Acrylic acid homopolymer
* Acrylic acid resin
* Acrylic polymer
* Acrylic resin
* Acrysol A 1
* Acrysol A 3
* Acrysol A 5
* Acrysol AC 5
* Acrysol ase-75
* Acrysol WS-24
* Antiprex A
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Antiprex 461
Arasorb 750
Arasorb S 100F
Arolon
Aron
Aron A 10H
Atactic poly(acrylic acid)
Carbopol 960
Carbopol 961
Carboset 515
Carboset Resin No. 515
Carboxypolymethylene
Carboxy vinyl polymer
Carpolene
Colloids 119/50
Dispex C40
G-Cure
Good-rite K 37
Good-rite K-700
Good-rite K 702
Good-rite K727
Good-rite WS 801
Haloflex 202
Haloflex 208
Junlon 110
Jurimer AC 10H
Jurimer AC 10P
Nalfloc 636
Neocryl A-1038
OLD 01
PAA-25
PA 11M
P 11H
Polyacrylate elastomers
Poly(acrylic acid)
Polymer, carboxy vinyl
Polytex 973
2-Propenoic acid homopolymer
R968
Racryl
Revacryl A 191
Sokalan PAS
Solidokoll N
Synthemul 90-588
TB 1131
Tecpol
Texcryl
Versicol E 7
Versicol E9
Versicol E15
Versicol S 25
Viscalex HV 30
Viscon 103
WS 24
WS 801
XPA
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub.,
Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.11962Volume(issue)/page/year: 14,94,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia,
Italy)
V.8-43
1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 25,721,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 21,652,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZMEIAV Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii. Journal of
Microbiology, Epidemiology, and Immunology. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.141935- Volume(issue)/page/year:
(9),14,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 114,258,1958
V.4-
*** REVIEWS ***
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 19,47,1979
IARC Cancer Review:Animal No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 19,47,1979
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82129
No. of Facilities: 2084 (estimated)
No. of Industries: 44
No. of Occupations: 55
No. of Employees: 34007 (estimated)
NOES - National Occupational
NOES Hazard Code - X7610
No. of Facilities: 31268
No. of Industries: 198
No. of Occupations: 162
No. of Employees: 571954
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
232712 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CARBORUNDUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Annanox CK
* Betarundum
* Betarundum ST-S
* Betarundum UF
* Betarundum ultrafine
* Carbofrax M
* Carbolon
* Carbon silicide
* Carborundeum
* Carborundum
* Crystar
* Crystolon 37
* Crystolon 39
* Densic C 500
* DU-A 1
* DU-A 2
* DU-A 3
* DU-A 4
* DU-A 3C
* GC 10000
* Green densic
* Green densic GC 800
* Hitaceram SC 101
* KZ 3M
* KZ 5M
* KZ 7M
* SC 9
* SC 9 (Carbide)
* SC 201
* SCW 1
* SD-GP 6000
* SD-GP 8000
* Silicon carbide
* Silicon monocarbide
* Silundum
VW0450000
Silicon carbide
409-21-2
12504-67-5
66039-27-8
199907
30
C-Si
40.10
.SI..C
Tumorigen
*
*
*
*
*
*
*
Tokawhisker
UA 1
UA 2
UA 3
UA 4
UF 15
YE 5626
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/m3/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16,128,1991
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology.
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.11979Volume(issue)/page/year: 11(2),13,1989
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,965,1981
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 10 mg/m3, total dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:NUISANCE PARTICULATES
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,28,1973
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 4 mg/m3, JAN1999
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-GERMANY:TWA 4 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 4 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO SILICON CARBIDE, resp. fraction-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO SILICON CARBIDE, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 17525
No. of Facilities: 25235 (estimated)
No. of Industries: 184
No. of Occupations: 97
No. of Employees: 268082 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4228
No. of Facilities: 158 (estimated)
No. of Industries: 4
No. of Occupations: 12
No. of Employees: 8693 (estimated)
No. of Female Employees: 84 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6494
No. of Facilities: 1250 (estimated)
No. of Industries: 25
No. of Occupations: 22
No. of Employees: 17481 (estimated)
No. of Female Employees: 1482 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 17525
No. of Facilities: 13729 (estimated)
No. of Industries: 129
No. of Occupations: 97
No. of Employees: 250945 (estimated)
No. of Female Employees: 19568 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CARBOXYBENZALDEHYDE (2-)
RTECS NUMBER
: TH7015000
CHEMICAL NAME
: Phthalaldehydic acid
CAS REGISTRY NUMBER
: 119-67-5
BEILSTEIN REFERENCE NO. : 0742381
REFERENCE
: 4-10-00-02748 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C8-H6-O3
MOLECULAR WEIGHT
: 150.14
SYNONYMS/TRADE NAMES :
* Benzoic acid, 2-formyl* o-Carboxybenzaldehyde
* 2-Carboxybenzaldehyde
* o-Formylbenzoic acid
* 2-Formylbenzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 27,665,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 27,665,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 27,665,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 27,665,1974
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBOXYBENZALDEHYDE (4-)
RTECS NUMBER
: WZ0440000
CHEMICAL NAME
: Terephthalaldehydic acid
CAS REGISTRY NUMBER
: 619-66-9
BEILSTEIN REFERENCE NO. : 0471734
REFERENCE
: 4-10-00-02752 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H6-O3
MOLECULAR WEIGHT
: 150.14
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzoic acid, 4-formyl* p-Carboxybenzaldehyde
* 4-Carboxybenzaldehyde
* p-Formylbenzoic acid
* 4-Formylbenzoic acid
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBOXYBENZENESULFONAMIDE (4-)
RTECS NUMBER
: DH6820000
CHEMICAL NAME
: Benzoic acid, p-sulfamoylCAS REGISTRY NUMBER
: 138-41-0
BEILSTEIN REFERENCE NO. : 1875393
REFERENCE
: 4-11-00-00690 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H7-N-O4-S
MOLECULAR WEIGHT
: 201.21
WISWESSER LINE NOTATION : ZSWR DVQ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 4-(Aminosulfonyl)benzoic acid
* Benzoic acid, 4-(aminosulfonyl)* Benzoic acid p-sulfamide
* p-Carboxybenzenesulfonamide
* 4-Carboxybenzenesulfonamide
* Carzenid
* Carzenide
* Dirnate
* p-Sulfamoylbenzoic acid
* 4-Sulfamoylbenzoic acid
* p-Sulfamylbenzoic acid
* p-Sulfonamidobenzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
38,102,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
>1 gm/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 8,548,1965
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBOXYMETHANEPHOSPHONIC ACID
RTECS NUMBER
: AJ3278000
CHEMICAL NAME
: Acetic acid, phosphonoCAS REGISTRY NUMBER
: 4408-78-0
BEILSTEIN REFERENCE NO. : 1764355
REFERENCE
: 4-04-00-03612 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C2-H5-O5-P
MOLECULAR WEIGHT
: 140.04
SYNONYMS/TRADE NAMES :
* Carboxymethanephosphonic acid
* Fosfonet
* Phosphonacetic acid
* Phosphonoacetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 16,132,1974
CARBOXYMETHOXYLAMINE HEMIHYDROCHLORIDE
RTECS NUMBER
: AF3150000
CHEMICAL NAME
: Acetic acid, 2-aminooxy-, hydrochloride (2:1)
CAS REGISTRY NUMBER
: 2921-14-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C4-H10-N2-O6.Cl-H
MOLECULAR WEIGHT
: 218.62
WISWESSER LINE NOTATION : ZO1VQ 2 &GH
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Aminooxyacetic acid hemichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington,
DC)
V.1-5, 1959-62. For publisher information, see JMCMAR.
Volume(issue)/page/year: 5,464,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 91 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall,
Oxford OX3 OBW, UK) V.91970- Volume(issue)/page/year: 21,803,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARBOXYMETHYL CELLULOSE SODIUM
RTECS NUMBER
: FJ5950000
CHEMICAL NAME
: Cellulose, carboxymethyl ether, sodium salt
CAS REGISTRY NUMBER
: 9004-32-4
LAST UPDATED
: 199710
DATA ITEMS CITED
: 15
COMPOUND DESCRIPTOR
: Tumorigen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* AC-Di-sol. NF
* Aku-W 515
* Aquaplast
* B 10
* B 10 (Polysaccharide)
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Blanose BS 190
Blanose BWM
Carbose 1M
Carboxymethylcellulose, sodium salt
Carmethose
Cellofas
Cellofas B
Cellofas B5
Cellofas B6
Cellofas B50
Cellofas C
Cellogel C
Cellogen 3H
Cellogen PR
Cellogen WS-C
Cellpro
Cellufix FF 100
Cellugel
Cellulose glycolic acid, sodium salt
Cellulose sodium glycolate
CMC 2
CMC 41A
CM-Cellulose sodium salt
CMC 7H
CMC 4H1
CMC 7H3SF
CMC 7L1
CMC 7M
CMC 4M6
CMC 7MT
CMC 3M5T
CMC sodium salt
Collowel
Copagel PB 25
Courlose A 590
Courlose A 610
Courlose A 650
Courlose F 4
Courlose F 8
Courlose F 20
Courlose F 370
Courlose F 1000G
Daicel 1150
Daicel 1180
Edifas B
Ethoxose
Fine Gum HES
Glikocel TA
7H3SF
KMTs 212
KMTs 300
KMTs 500
KMTs 600
Lovosa
Lovosa 20alk.
Lovosa TN
Lucel (polysaccharide)
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Majol PLX
Modocoll 1200
NaCm-cellulose salt
Nymcel S
Nymcel slc-T
Nymcel ZSB 10
Nymcel ZSB 16
Polyfibron 120
Sanlose SN 20A
Sarcell tel
S 75M
Sodium carboxmethylcellulose
Sodium carboxymethyl cellulose
Sodium cellulose glycolate
Sodium CMC
Sodium CM-cellulose
Sodium glycolate cellulose
Sodium salt of carboxymethylcellulose
Tylose 666
Tylose C
Tylose C 30
Tylose C 300
Tylose C 600
Tylose CB 200
Tylose CBR 400
Tylose CBR series
Tylose CBS 30
Tylose CBS 70
Tylose CB series
Tylose C 1000P
Tylose CR
Tylose CR 50
Tylose DKL
Unisol RH
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27000 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5800 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1(Suppl),243,1992
1977-
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >27 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,
Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:
17,351,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >27 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,
Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:
17,351,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
(Suppl),243,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 16000 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 227 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
33,909,1995
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1900 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
13BYAH "Morphological Precursors of Cancer, Proceedings of an
International
Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of
Perugia, 1962 Volume(issue)/page/year: -,83,1962
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8600 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
13BYAH "Morphological Precursors of Cancer, Proceedings of an
International
Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of
Perugia, 1962 Volume(issue)/page/year: -,83,1962
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 33 gm/kg/22W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 18,225,1977
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 140 mg/kg
SEX/DURATION
: male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 14,623,1977
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1474
No. of Facilities: 13501 (estimated)
No. of Industries: 93
No. of Occupations: 102
No. of Employees: 318345 (estimated)
No. of Female Employees: 184422 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8786
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CARBOXYPHENYLBORONIC ACID (3-)
RTECS NUMBER
: CY8750000
CHEMICAL NAME
: Benzeneboronic acid, m-carboxyCAS REGISTRY NUMBER
: 25487-66-5
BEILSTEIN REFERENCE NO. : 2967400
REFERENCE
: 3-16-00-01283 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H7-B-O4
MOLECULAR WEIGHT
: 165.95
WISWESSER LINE NOTATION : VHOR CBQQ
SYNONYMS/TRADE NAMES :
* Benzoic acid, m-borono* Benzoic acid, 3-borono* m-Carboxybenzeneboronic acid
* m-Carboxyphenylboronic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa,
Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 12,173,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
CARBOXYPHENYLBORONIC ACID (4-)
RTECS NUMBER
: CY8925000
CHEMICAL NAME
: Benzeneboronic acid, p-carboxyCAS REGISTRY NUMBER
: 14047-29-1
BEILSTEIN REFERENCE NO. : 3031088
REFERENCE
: 4-16-00-01683 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H7-B-O4
MOLECULAR WEIGHT
: 165.95
WISWESSER LINE NOTATION : VHOR DBQQ
SYNONYMS/TRADE NAMES :
* Benzoic acid, p-borono* Benzoic acid, 4-borono* p-Boronobenzoic acid
* p-Carboxybenzeneboronic acid
* p-Carboxyphenylboronic acid
* 4-Carboxyphenylboronic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa,
Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 12,173,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1740 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
CARMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* B Rose liquid
:
:
:
:
:
:
FH8891000
Carmine
1390-65-4
199504
2
Mutagen
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2882
No. of Facilities: 96 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 1771 (estimated)
No. of Female Employees: 1637 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
CARNITINE (L-)
RTECS NUMBER
CHEMICAL NAME
: BP2980000
: Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-,
hydroxide, inner salt, LCAS REGISTRY NUMBER
: 541-15-1
OTHER CAS REGISTRY NOS. : 7634-98-2
LAST UPDATED
: 199107
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H15-N-O3
MOLECULAR WEIGHT
: 161.23
WISWESSER LINE NOTATION : OV1YQ1K1&1&1
COMPOUND DESCRIPTOR
: Drug
Natural Product
SYNONYMS/TRADE NAMES :
* (3-Carboxy-2-hydroxypropyl)trimethyl-ammonium hydroxide, inner salt
* 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner
salt
* Carnitine
* (-)-Carnitine
* l-Carnitine
* (R)-Carnitine
* Karnitin
* 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner
salt, (R)* gamma-Trimethyl-ammonium-beta-hydroxybutirate
* gamma-Trimethyl-beta-hydroxybutyrobetaine
* Vitamin BT
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
35,645,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87.
For
publisher information, see JNCIEQ. Volume(issue)/page/year: 63,558,1979
CARNITINE HYDROCHLORIDE (DL-)
RTECS NUMBER
: BP2979140
CHEMICAL NAME
: Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-,
chloride, (+-)CAS REGISTRY NUMBER
: 461-05-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H16-N-O3.Cl
MOLECULAR WEIGHT
: 197.69
SYNONYMS/TRADE NAMES :
* Bicarnesine
* (+-)-(3-Carboxy-2-hydroxypropyl)trimethylammonium chloride
* (+-)-Carnitine chloride
* DL-Carnitine chloride
* (+-)-Carnitine hydrochloride
* d,l-Carnitine hydrochloride
* DL-Carnitine hydrochloride
* 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (+-)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
3,28,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - fluid intake
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
3,28,1959
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CAROTENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* beta-Carotene
* C.I. 75130
* Karotin
* KPMK
:
:
:
:
:
:
:
:
FI0329500
beta-Carotene, all-trans7235-40-7
199701
4
C40-H56
536.96
Mutagen
* Natural Yellow 26
* Serlabo
* Zlut prirodni 26
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83866
No. of Facilities: 1542 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 9334 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83866
No. of Facilities: 404 (estimated)
No. of Industries: 5
No. of Occupations: 13
No. of Employees: 13339 (estimated)
No. of Female Employees: 4881 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARRAGEENAN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* lambda-Carrageenin
:
:
:
:
:
:
FI0704000
lambda-Carrageenan
9064-57-7
199512
2
Natural Product
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Vascular - thrombosis distant from injection site
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - other changes
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK)
57,455,1976
V.1-
1920-
Volume(issue)/page/year:
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 mg/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 17,647,1965
CARVONE (R-)
RTECS NUMBER
: OS8650000
CHEMICAL NAME
: p-Mentha-6,8-dien-2-one, (R)-(-)CAS REGISTRY NUMBER
: 6485-40-1
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C10-H14-O
MOLECULAR WEIGHT
: 150.24
WISWESSER LINE NOTATION : L6V BUTJ B1 EY1&U1
SYNONYMS/TRADE NAMES :
* (-)-Carvone
* l-Carvone
* L(-)-Carvone
* (R)-Carvone
* 2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (R)* p-Mentha-6,8-dien-2-one, (-)* l-6,8(9)-p-Menthadien-2-one
* l-1-Methyl-4-isopropenyl-6-cyclohexen-2-one
* (R)-2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-one
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1057,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intravenous
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02834
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 766 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1057,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X8585
No. of Facilities: 459 (estimated)
No. of Industries: 8
No. of Occupations: 39
No. of Employees: 19245 (estimated)
No. of Female Employees: 10383 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CARVONE (S,+-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Carvone, (+)* (+)-Carvone
* d-Carvone
* D(+)-Carvone
:
:
:
:
:
:
:
:
OS8670000
p-Mentha-6,8-dien-2-one, (S)-(+)2244-16-8
199904
9
C10-H14-O
150.24
Tumorigen
Mutagen
Primary Irritant
*
*
*
*
*
*
*
(S)-Carvone
(S)-(+)-Carvone
2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-, (S)d-p-Mentha-6,8,(9)-dien-2-one
(S)-d-p-Mentha-6,8,(9)-dien-2-one
(S)-(+)-p-Mentha-6,8-dien-2-one
d-1-Methyl-4-isopropenyl-6-cyclohexen-2-one
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,673,1978
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3710 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,673,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4 mL/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,673,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 19080 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
(Research
NTP-TR-381,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48750 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-381,1990
(Research
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 12500 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-381,1990
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 167 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-381,1990
(Research
(Research
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (gavage);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-381,1990
CASEIN SODIUM
RTECS NUMBER
: FI3540000
CHEMICAL NAME
: Casein, sodium complex
CAS REGISTRY NUMBER
: 9005-46-3
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Casein-sodium
* Caseins, sodium complexes
* Nutrose
* Sodium caseinate
(Research
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 45 gm/kg/15D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
57,1367,1976
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83823
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 207 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83823
No. of Facilities: 1278 (estimated)
No. of Industries: 13
No. of Occupations: 22
No. of Employees: 22173 (estimated)
No. of Female Employees: 7710 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CASTOR OIL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
FI4100000
Castor oil
8001-79-4
8021-37-2
199907
11
Tumorigen
Primary Irritant
*
*
*
*
*
*
*
*
*
*
*
*
Aromatic castor oil
Castor oil aromatic
Cosmetol
Crystal O
Gold bond
NCI-C55163
Neoloid
Oil of Palma christi
Phorbyol
Ricinus oil
Ricirus oil
Tangantangan oil
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 50 mg/48H
REACTION SEVERITY
: Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1030
No. of Facilities: 34810 (estimated)
No. of Industries: 259
No. of Occupations: 134
No. of Employees: 487959 (estimated)
NOES - National Occupational
NOES Hazard Code - M1030
No. of Facilities: 32342
No. of Industries: 195
No. of Occupations: 136
No. of Employees: 444011
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
172359 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Toxicity studies, RPT# TOX-12, May 1999
CATALASE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Caperase
* E.C. 1.11.1.6
* Equilase
* Optidase
:
:
:
:
:
:
FI4378000
Catalase
9001-05-2
199701
3
Mutagen
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 5 pph
REFERENCE :
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy
of
Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State
Univ., Weatherford, OK 73096) V.11910/1920Volume(issue)/page/year:
34,114,1953
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9705
No. of Facilities: 122 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 2806 (estimated)
No. of Female Employees: 2026 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CATECHOL CRYSTALLINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
UX1050000
Pyrocatechol
120-80-9
0471401
4-06-00-05557 (Beilstein Handbook Reference)
199907
76
C6-H6-O2
110.12
QR BQ
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzene, o-dihydroxy* o-Benzenediol
* 1,2-Benzenediol
* Catechin (phenol)
* Catechol
* Catechol (phenol)
* C.I. 76500
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
C.I. Oxidation Base 26
o-Dihydroxybenzene
1,2-Dihydroxybenzene
o-Dioxybenzene
o-Diphenol
Durafur developer C
Fouramine PCH
Fourrine 68
o-Hydroquinone
o-Hydroxyphenol
2-Hydroxyphenol
Katechol
NCI-C55856
Oxyphenic acid
Pelagol Grey C
o-Phenylenediol
Phthalhydroquinone
Pyrocatechin
Pyrocatechine
Pyrokatechin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AFREAW Advances in Food Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1-32, 1948-88. Volume(issue)/page/year: 3,197,1951
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 176,193,1968
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AFREAW Advances in Food Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1-32, 1948-88. Volume(issue)/page/year: 3,197,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 64,247,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 247 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
5,143,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,62,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Blood - leukopenia
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2A,2585,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
37,596,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 17,497,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AFREAW Advances in Food Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1-32, 1948-88. Volume(issue)/page/year: 3,197,1951
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Intraperitoneal
Rodent - guinea pig
150 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,62,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,62,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,62,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 15,136,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 98 gm/kg/4W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 29,568,1970
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 437 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 81,207,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 645 gm/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 81,207,1990
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60640 mg/kg/24W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 77,854,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TD - Toxic dose (other than lowest)
: Oral
: Rodent - rat
DOSE/DURATION
: 349 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
33,93,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 171 gm/kg/51W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 85,17,1994
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 41,43,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
57,466,1955
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 15 umol/plate
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 20,117,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 4 ug/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB
5050,
Tokyo International, Tokyo 100-31, Japan) V.251961Volume(issue)/page/year: 45,327,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 500 mg/L
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11953Volume(issue)/page/year: 32,171,1986
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 300 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,109,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,235,1996
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,235,1987
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
26,305,1995
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
92,427,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 40 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1189,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 40 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1189,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 mmol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
63,47,1992
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 74,1283,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
208,61,1988
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Micronucleus test
Intraperitoneal
Rodent - mouse
10 mg/kg
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,29,1994
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,155,1988
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 250 umol/L
REFERENCE :
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston
St.,
Baltimore, MD 21202) V.11965- Volume(issue)/page/year: 28,560,1985
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2500 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,523,1988
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 25 umol/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 82,81,1989
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Cytogenetic analysis
: Rodent - hamster Embryo
: 3 umol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 50 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
14,251,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 12500 nmol/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 82,81,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rabbit Bone marrow
DOSE/DURATION
: 2 mmol/L
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
7,485,1985
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 23 mg/m3 (5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,155,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,155,1977
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
47,75,1978
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 5 ppm (20 mg/m3), JAN1999
OEL-BELGIUM:TWA 5 ppm (23 mg/m3) JAN 1993
OEL-DENMARK: TWA 5 ppm (20 mg/m3), JAN1999
OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (45 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (23 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3) JAN 1993
OEL-SWEDEN: NGV 5 ppm (20 mg/m3), KTV 10 ppm (40 mg/m3), Skin, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CATECHOL-air:10H TWA 5 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1763
No. of Facilities: 147 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 642 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1763
No. of Facilities: 700 (estimated)
No. of Industries: 8
No. of Occupations: 15
No. of Employees: 13516 (estimated)
No. of Female Employees: 5799 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CBZ PROLINE
RTECS NUMBER
: UY0745000
CHEMICAL NAME
: 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester,
LCAS REGISTRY NUMBER
: 1148-11-4
LAST UPDATED
: 199406
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C13-H15-N-O4
MOLECULAR WEIGHT
: 249.29
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzyloxycarbonylproline
* Benzyloxycarbonyl-L-proline
*
*
*
*
*
*
*
*
N-Benzyloxycarbonylproline
1-(Benzyloxycarbonyl)proline
Carbobenzoxy-L-proline
Carbobenzoxy-S-proline
N-Carbobenzoxy-L-proline
Carbobenzyloxy-L-proline
L-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester
1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 68,696,1979
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 280 mg/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 68,696,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 280 ug/kg
SEX/DURATION
: female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 68,696,1979
CEDAR WOOD OIL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
:
:
:
:
:
:
FJ1520050
Cedarwood oil
8000-27-9
199706
7
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Oil cedar
* Oil of cedar wood
* Oils, cedarwood
* Red cedarwood oil
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,845,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,845,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,845,1974
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1821
No. of Facilities: 236 (estimated)
No. of Industries: 5
No. of Occupations: 30
No. of Employees: 10360 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1821
No. of Facilities: 7990 (estimated)
No. of Industries: 67
No. of Occupations: 67
No. of Employees: 117858 (estimated)
No. of Female Employees: 55030 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CELITE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
VV7311000
Silica, amorphous - diatomaceous earth
61790-53-2
12750-99-1
29847-98-1
37337-67-0
54511-18-1
56748-40-4
67016-73-3
: 199907
: 24
: Tumorigen
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Celite
* Diatomaceous earth, natural
* Kieselguhr
* Silica, amorphous, diatomaceous earth, containing >1 % crystalline
silica
* Silica, amorphous - diatomaceous earth (uncalcined)
*** REVIEWS ***
ACGIH TLV-TWA 3 mg/m3, total dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 10 mg/m3, total dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 42,39,1987
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 42,39,1987
IARC Cancer Review:Animal Inadeauate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 68,41,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 68,41,1997
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 68,41,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-dust in air:TWA 20 mccpf
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,33,1973
OSHA PEL (Gen Indu):8H TWA 80 mg/m3/%SiO2
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 80 mg/m3/%SiO2
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 20 mppcf/(%SiO2+5)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 20 mppcf/(%SiO2+5)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY:TWA 4 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 4 mg/m3, JAN1999
OEL-THAILAND:TWA 80 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 3 mg/m3 (resp. dust) JAN 1993
OEL-UNITED KINGDOM:TWA 6 mg/m3 (total dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO SILICA, amorphous,diatomaceous earth-air:TWA 6 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3017
No. of Facilities: 11151 (estimated)
No. of Industries: 109
No. of Occupations: 97
No. of Employees: 169362 (estimated)
No. of Female Employees: 24496 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Silica, amorphous, 7501
CELLULOSE
RTECS NUMBER
: FJ5700000
CHEMICAL NAME
: Cellulose, carboxymethyl ether
CAS REGISTRY NUMBER
: 9000-11-7
LAST UPDATED
: 199701
DATA ITEMS CITED
: 8
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Almelose
* Apergel
* Apeyel
* Carbose
* Carboxymethylated cellulose pulp
* Carboxymethylcellulose
* Carboxymethyl cellulose ether
* Cellulose carboxymethylate
* Celluloseglycolic acid
* Cellulose GUM 7H
* CMC
* CM-Cellulose
* CMC-4LF
* Colloresine
* Glycocel TA
* Glycolic acid cellulose ether
* 7H
* 7H (carbohydrate)
* KMTs
* Thylose
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 9,175,1944
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intravenous
: Rodent - mouse
DOSE/DURATION
: 47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry.
(New
York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
2,274,1970
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 9,175,1944
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 9,175,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 13340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(5),14,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80349
No. of Facilities: 13908 (estimated)
No. of Industries: 115
No. of Occupations: 92
No. of Employees: 237435 (estimated)
NOES - National Occupational
NOES Hazard Code - 80349
No. of Facilities: 11923
No. of Industries: 108
No. of Occupations: 114
No. of Employees: 285427
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
45766 (estimated)
(V/O
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CELLULOSE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
FJ5691460
Cellulose
9004-34-6
9006-02-4
39394-43-9
58968-67-5
61991-21-7
61991-22-8
84503-75-3
99331-82-5
: 199712
: 25
LAST UPDATED
DATA ITEMS CITED
SYNONYMS/TRADE NAMES :
* Abicel
* beta-Amylose
* Arbocel
* Arbocel BC 200
* Arbocell B 600/30
* Avicel
* Avicel 101
* Avicel 102
* Avicel CL 611
* Avicel PH 101
* Avicel PH 105
* Cellex MX
* Cellulose
* alpha-Cellulose
* Cellulose 248
* Cellulose crystalline
* Celufi
* CEPO
* Cepo CFM
* CEPO S 20
* CEPO S 40
* Chromedia CC 31
* Chromedia CF 11
* Cupricellulose
* Elcema F 150
* Elcema G 250
* Elcema P 050
* Elcema P 100
* Fresenius D 6
* Heweten 10
* Hydroxycellulose
* Kingcot
* LA 01
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Microcrystalline cellulose
MN-Cellulose
Onozuka P 500
Pyrocellulose
Rayophane
Rayweb Q
Rexcel
Sigmacell
Solka-fil
Solka-floc
Solka-floc BW
Solka-floc BW 20
Solka-floc BW 100
Solka-floc BW 200
Solka-floc BW 2030
Spartose OM-22
Sulfite cellulose
Tomofan
Tunicin
Whatman CC-31
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
(Suppl),243,1992
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5800 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
(Suppl),243,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >31600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 50A,83,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
(Suppl),243,1992
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3, total dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-RUSSIA:TWA 2 mg/m3;STEL 4 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 (total dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CELLULOSE, respirable fraction-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CELLULOSE, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CEPHALOTHIN SODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: XI0388300
: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
acid, 3-(hydroxymethyl)-8-oxo-7-(2-(2thienyl)acetamido)-, acetate, monosodium salt
: 58-71-9
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
199609
27
C16-H15-N2-O6-S2.Na
418.44
T46 ANV ES GUTJ G1OV1 HVO CMV1- BT5SJ &-NADrug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Averon-1
* Cefalothine sodium
* Cefalothin sodium
* Cefalotina sodica
* Cephalothin sodium
* Ceporacin
* Cepovenin
* Chephalotin
* Coaxin
* Keflin
* Lilly 38253
* Lospoven
* Microtin
* Sodium cephalothin
* Synclotin
* 7-(Thiophene-2-acetamido)cephalosporanic acid sodium salt
* Toricelocin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
77,401,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 89 mg/kg/19D-I
TOXIC EFFECTS :
Blood - agranulocytosis
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,272,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 955 mg/kg/22D-I
TOXIC EFFECTS :
Blood - agranulocytosis
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70).
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,272,1963
(Ann Arbor, MI)
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 27,746,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85,
1940-78. Volume(issue)/page/year: 70,1123,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5600 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,231,1975
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,81,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5670 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - hair
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 27,746,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11975- Volume(issue)/page/year:
6(Suppl A),79,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - hair
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 27,746,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intramuscular
Rodent - mouse
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.11972Volume(issue)/page/year: 1,67,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - nausea or vomiting
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,205,1975
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals
Div., POB 37005, Chicago, IL 60637) V.11904Volume(issue)/page/year:
137,S51,1978
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals
Div., POB 37005, Chicago, IL 60637) V.11904Volume(issue)/page/year:
137,S51,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85,
1940-78. Volume(issue)/page/year: 70,1123,1963
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85,
1940-78. Volume(issue)/page/year: 70,1123,1963
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 96 gm/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 27,746,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 78 gm/kg/26W-I
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,195,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 63 gm/kg/21D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8
Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.11953- Volume(issue)/page/year:
26(Suppl 1),185,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
72900 mg/kg/31D-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,231,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 48 gm/kg/30D-I
TOXIC EFFECTS :
Endocrine - changes in thyroid weight
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 27,746,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 52 gm/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,205,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 15 gm/kg/10D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - nausea or vomiting
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,205,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83944
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1650 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83944
No. of Facilities: 620 (estimated)
No. of Industries: 1
No. of Occupations: 11
No. of Employees: 22644 (estimated)
No. of Female Employees: 18457 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
CERIUM CHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Cerium(III) chloride
* Cerium trichloride
* Cerous chloride
FK5075000
Cerium chloride
7790-86-5
199701
12
Ce-Cl3
246.47
CE G3
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2111 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 100,230,1923
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6262 ug/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa,
Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 32,205,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5277 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 97849 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 188,465,1938
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 104 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - anorexia (human)
Behavioral - muscle weakness
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
15,9,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 211 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
*** REVIEWS ***
TOXICOLOGY REVIEW
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 54,663,1965
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CERIUM(III) NITRATE HEXAHYDRATE
RTECS NUMBER
: FK6300000
CHEMICAL NAME
: Cerium(III) nitrate, hexahydrate (1:3:6)
CAS REGISTRY NUMBER
: 10294-41-4
LAST UPDATED
: 199406
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: N3-O9.Ce.6H2-O
MOLECULAR WEIGHT
: 434.27
WISWESSER LINE NOTATION : CE N-O3*3 &QH 6
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Cerium nitrate, hexahydrate
* Cerium trinitrate hexahydrate
* Cerous nitrate hexahydrate
* Nitric acid, cerium(3+) salt, hexahydrate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 12,615,1993
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 12,615,1993
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,750,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,750,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,750,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
5,750,1963
*** REVIEWS ***
TOXICOLOGY REVIEW
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 54,663,1965
CESIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Cesium-133
:
:
:
:
:
:
:
:
FK9225000
Cesium
7440-46-2
199710
4
Cs
132.91
.CS
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,704,1948
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4471
No. of Facilities: 1342 (estimated)
No. of Industries: 14
No. of Occupations: 20
No. of Employees: 8114 (estimated)
No. of Female Employees: 1276 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CESIUM BROMIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
SYNONYMS/TRADE NAMES :
* Tricesium tribromide
FK9275000
Cesium bromide
7787-69-1
199701
4
Br-Cs
212.82
CS E
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHOAX Archives of Industrial Hygiene and Occupational Medicine.
(Chicago,
IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
Volume(issue)/page/year: 1,637,1950
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1079
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 21 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1079
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1452 (estimated)
No. of Female Employees: 230 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM CARBONATE
RTECS NUMBER
: FK9400000
CHEMICAL NAME
: Cesium carbonate
CAS REGISTRY NUMBER
: 534-17-8
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C-O3.2Cs
MOLECULAR WEIGHT
: 325.83
WISWESSER LINE NOTATION : .CS2.C-O3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Carbonic acid, dicesium salt
* Cesium carbonate (Cs2CO3)
* Dicesium carbonate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
FK9625000
Cesium chloride
7647-17-8
199701
15
Cl-Cs
168.36
CS G
Mutagen
Reproductive Effector
* Cesium monochloride
* Dicesium dichloride
* Tricesium trichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHOAX Archives of Industrial Hygiene and Occupational Medicine.
(Chicago,
IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
Volume(issue)/page/year: 1,637,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2306 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 910 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
56(4),118S,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
56(4),118S,1960
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
706 mg/kg
female 1-21 day(s) pre-mating
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.61975- Volume(issue)/page/year:
25,395,1994
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
262 gm/kg
female 1-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
PHBHA4 Physiology and Behavior. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11966Volume(issue)/page/year:
46,89,1989
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
1,21,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
244,295,1990
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
244,295,1990
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3874
No. of Facilities: 189 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 3353 (estimated)
No. of Female Employees: 1792 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM FLUORIDE
RTECS NUMBER
: FK9650000
CHEMICAL NAME
: Cesium fluoride
CAS REGISTRY NUMBER
: 13400-13-0
LAST UPDATED
: 199907
DATA ITEMS CITED
: 25
MOLECULAR FORMULA
: Cs-F
MOLECULAR WEIGHT
: 151.91
WISWESSER LINE NOTATION : .CS..F
SYNONYMS/TRADE NAMES :
* Cesium monofluoride
* Dicesium difluoride
* Tricesium trifluoride
*** REVIEWS ***
ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,116,1971
OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993
OEL-AUSTRIA: MAK 2.5 mg(F)/m3, JAN1999
OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 1 mg(HF)/m3, MAC(STEL) 3 mg(HF)/m3, JAN1999
OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993
OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993
OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM HYDROXIDE
RTECS NUMBER
: FK9800000
CHEMICAL NAME
: Cesium hydroxide
CAS REGISTRY NUMBER
: 21351-79-1
LAST UPDATED
: 199907
DATA ITEMS CITED
: 19
MOLECULAR FORMULA
: Cs-H-O
MOLECULAR WEIGHT
: 149.92
WISWESSER LINE NOTATION : CS Q
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Cesium hydrate
* Cesium hydroxide
* Cesium hydroxide dimer
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,239,1975
TYPE OF TEST
: Rinsed with water
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/5M
REACTION SEVERITY
: Severe
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,239,1975
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 570 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(1),29,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHOAX Archives of Industrial Hygiene and Occupational Medicine.
(Chicago,
IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
Volume(issue)/page/year: 1,637,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - tetany
REFERENCE :
20PKA3 "Novye Dannye Po Toksikologii Redkikh Metalov Ikh Soedinenii," New
Data on the Toxicology of Rare Metals and Their Compounds, Izrael'son,
Z.I.,
ed., Moscow, Izdatel'stvo "Meditsina," 1967 Volume(issue)/page/year:
-,-,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10110 ug/m3/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(1),29,1977
*** REVIEWS ***
ACGIH TLV-TWA 2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 mg/m3 JAN 1993
OEL-BELGIUM:TWA 2 mg/m3 JAN 1993
OEL-DENMARK: TWS 2 mg/m3, JAN1999
OEL-FINLAND:TWA 2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2 mg/m3 JAN 1993
OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 2 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CESIUM HYDROXIDE-air:10H TWA 2.0 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM IODIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
SYNONYMS/TRADE NAMES :
* Cesium monoiodide
* Dicesium diiodide
* Tricesium triiodide
FL0350000
Cesium iodide
7789-17-5
199701
4
Cs-I
259.81
CS I
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 2386 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: TR-74,1,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHOAX Archives of Industrial Hygiene and Occupational Medicine.
(Chicago,
IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
Volume(issue)/page/year: 1,637,1950
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4474
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1452 (estimated)
No. of Female Employees: 230 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM NITRATE
RTECS NUMBER
: FL0700000
CHEMICAL NAME
: Cesium(I) nitrate (1:1)
CAS REGISTRY NUMBER
: 7789-18-6
LAST UPDATED
: 199701
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: N-O3.Cs
MOLECULAR WEIGHT
: 194.92
WISWESSER LINE NOTATION : CS N-O3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Nitric acid, cesium salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHOAX Archives of Industrial Hygiene and Occupational Medicine.
(Chicago,
IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
Volume(issue)/page/year: 1,637,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4166
No. of Facilities: 10 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 1572 (estimated)
No. of Female Employees: 297 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CESIUM SULFATE
RTECS NUMBER
: FL0800000
CHEMICAL NAME
: Cesium sulfate
CAS REGISTRY NUMBER
: 10294-54-9
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: O4-S.2Cs
MOLECULAR WEIGHT
: 361.88
WISWESSER LINE NOTATION : .CS2.S-O4
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Dicesium sulfate
* Sulfuric acid, dicesium salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (8),10,1978
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CETYLPYRIDINIUM BROMIDE (1-)
RTECS NUMBER
: UU4848000
CHEMICAL NAME
: Pyridinium, 1-hexadecyl-, bromide
CAS REGISTRY NUMBER
: 140-72-7
LAST UPDATED
: 199812
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C21-H38-N.Br
MOLECULAR WEIGHT
: 384.51
WISWESSER LINE NOTATION : T6KJ A16 &E
COMPOUND DESCRIPTOR
: Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Acetoquat CPB
* Bromocet
* Cetapharm
* Cetasol
* Cetazol
* Cetylpyridinium bromide
* N-Cetylpyridinium bromide
* 1-Cetylpyridinium bromide
* Fixanol C
* Hexadecylpyridine bromide
* Hexadecylpyridinium bromide
* N-Hexadecylpyridinium bromide
* 1-Hexadecylpyridinium bromide
* Morpan CBP
* Nitrogenol
* Seprisan
* Sterogenol
* TsPB
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
475 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
22,148,1979
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >7200 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
22,148,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 21,121,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
40,273,1985
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8400 mg/kg/21D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Skin and Appendages - dermatitis, other (after systemic exposure)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.91966- Volume(issue)/page/year:
22,148,1979
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 28,504,1982
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CETYLPYRIDINIUM CHLORIDE
RTECS NUMBER
: UU5075000
CHEMICAL NAME
: Pyridinium, 1-hexadecyl-, chloride, monohydrate
CAS REGISTRY NUMBER
: 6004-24-6
LAST UPDATED
: 199603
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C21-H38-N.Cl.H2-O
MOLECULAR WEIGHT
: 358.07
WISWESSER LINE NOTATION : T6KJ A16 &G &QH
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Cepacol
* Cetylpyridinium chloride monohydrate
* 1-Hexadecylpyridinium chloride monohydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 74,401,1942
V.1-
CHALCONE (TRANS-)
RTECS NUMBER
: UD5576750
CHEMICAL NAME
: 2-Propen-1-one, 1,3-diphenyl-, (E)CAS REGISTRY NUMBER
: 614-47-1
LAST UPDATED
: 199812
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C15-H12-O
MOLECULAR WEIGHT
: 208.27
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* trans-Benzalacetophenone
* (E)-Benzylideneacetophenone
* trans-Benzylideneacetophenone
* Chalcone, (E)* (E)-Chalcone
* trans-Chalcone
* (E)-1,3-Diphenyl-2-propen-1-one
* Phenyl (E)-2-phenylethenyl ketone
* Phenyl trans-styryl ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1048 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 46,1163,1998
CHARCOAL ACTIVATED
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Acticarbone
* Activated carbon
* AG 3 (Adsorbent)
* AG 5
* AG 5 (Adsorbent)
* AK (Adsorbent)
* Amoco PX 21
* Anthrasorb
* AR 3
* ART 2
* AU 3
* BAU
* BG 6080
* Colgon BPL
* Colgon PCB-D
* Colgon PCB 12X30
* Canesorb
* Carbon-12
* Carbopol Extra
* Carbopol M
* Carbopol Z 4
* Carbopol Z Extra
* Carbosieve
* Carbosorbit R
* Cecarbon
* CF 8
* CF 8 (Carbon)
* CLF II
:
:
:
:
:
:
:
:
:
:
FF5250100
Carbon
7440-44-0
82600-58-6
199907
26
C
12.01
C
Reproductive Effector
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
CMB 50
CMB 200
Coke powder
Columbia LCK
CUZ 3
CWN 2
Darco
Filtrasorb
Filtrasorb 200
Filtrasorb 400
Grosafe
Hydrodarco
Irgalite 1104
Jado
K 257
MA 100 (Carbon)
Norit
Nuchar
OU-B
Pelikan C 11/1431a
SKG
SKT
SKT (adsorbent)
SU 2000
Suchar 681
Supersorbon IV
Supersorbon S 1
U 02
Watercarb
Witcarb 940
XE 340
XF 4175L
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,497,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 167 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,327,1971
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD:NUISANCE PARTICULATES
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,122,1971
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY:TWA 6 mg/m3 (resp. dust) JAN 1993
OEL-AUSTRIA: MAK 6 mg/m3 (resp. dust), JAN1999
OEL-SWITZERLAND:TWA 2.5 mg/m3 (resp. dust) JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 (inhalable dust) JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 (inhalable dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
OEL-SWEDEN: TWA 3 mg/m3 (dust), JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80243
No. of Facilities: 89481 (estimated)
No. of Industries: 397
No. of Occupations: 184
No. of Employees: 762484 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3261
No. of Facilities: 363 (estimated)
No. of Industries: 5
No. of Occupations: 11
No. of Employees: 3210 (estimated)
No. of Female Employees: 772 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9503
No. of Facilities: 29 (estimated)
No. of Industries: 3
No. of Occupations: 8
No. of Employees: 1427 (estimated)
No. of Female Employees: 1011 (estimated)
NOES - National Occupational
NOES Hazard Code - 80243
No. of Facilities: 36693
No. of Industries: 261
No. of Occupations: 131
No. of Employees: 467337
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
21198 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHENODEOXYCHOLIC ACID
RTECS NUMBER
:
CHEMICAL NAME
:
3-alpha,7-alpha-dihydroxyCAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
FZ1980000
5-beta-Cholan-24-oic acid,
474-25-9
199806
30
C24-H40-O4
392.64
L E5 B666TJ A1 E1 FY1&2VQ KQ OQ
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Anthropodeoxycholic acid
* Anthropodesoxycholic acid
* Anthropododesoxycholic acid
* CDC
* Chendol
* Chenic acid
* Chenodeoxycholic acid
* Chenodesoxycholic acid
* Chenodesoxycholsaeure
* Chenodiol
* Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)* 3-alpha,7-alpha-Dihydroxycholanic acid
* 3-alpha,7-alpha-Dihydroxy-5-beta-cholan-24-oic acid
* 3-alpha,7-alpha-Dihydroxycholansaeure
* Gallodesoxycholic acid
* 7-alpha-Hydroxylithocholic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 15,915,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 105 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
Skin and Appendages - hair
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 15,915,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Blood - changes in spleen
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 11,2499,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 106 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 15,915,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,397,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,464,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 86 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 15,915,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 11,2499,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 20,323,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 24,1157,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,397,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,464,1995
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3750 mg/kg/30D-C
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Related to Chronic Data - changes in prostate weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 15,961,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45500 mg/kg/26W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year:
15,1005,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18200 mg/kg/52W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 15,975,1978
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 24 gm/kg/5Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CLONEA Clinics in Oncology. (W.B. Saunders Co., W. Washington Sq.,
Philadelphia, PA 19105) V.11982- Volume(issue)/page/year:
7,245,1981
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB81-127581
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1785 mg/kg
SEX/DURATION
: female 4-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 246,149,1980
V.4-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 550 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Effects on Newborn - physical
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 16,51,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1375 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
1967-
Volume(issue)/page/year: 16,51,1978
TDLo - Lowest published toxic dose
Oral
Rodent - rat
3480 mg/kg
female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB81-127581
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Primate - monkey
14820 mg/kg
female 31 week(s) pre-mating
female 1-24 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
ANSUA5 Annals of Surgery. (Lippincott/Harper, Journal Fulfillment Dept.,
2350 Virginia Ave., Hagerstown, MD 21740) V.11885Volume(issue)/page/year: 184,490,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 1500 mg/kg
SEX/DURATION
: female 21-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 2,1021,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 1500 mg/kg
SEX/DURATION
: female 21-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 2,239,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 260 mg/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 16,33,1978
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
158,45,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1100 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
60,192,1987
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1100 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
60,192,1987
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,447,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK)
Volume(issue)/page/year: 15,1911,1994
CHITIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* beta-Chitin
* Chitina
:
:
:
:
:
:
:
:
V.1-
1980-
FM6125000
Chitin
1398-61-4
199701
2
C30-H50-N4-O19
770.84
/T6OTJ B& CMV1 DQ EO& F1Q/
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa
Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927Volume(issue)/page/year: 44,1685,1968
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHITINASE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Chitobiase
* Chitodextrinase
* E.C. 3.2.1.14
* Glucanase
* Laminarase
:
:
:
:
:
:
FM6205000
Chitinase
9001-06-3
199701
2
Drug
Natural Product
* Poly-beta-glucosaminidase
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),305,1980
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHITOSAN
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
SYNONYMS/TRADE NAMES :
* Chicol
* Chitopearl 3510
* Chitopearl BC 3000
* Chitopearl BCW 2500
* Chitopearl BCW 3000
* Chitopearl BCW 3500
* Chitopearl BCW 3505
* Chitopearl BCW 3507
* CTA 4
* Dac 70
* Deacetylchitin
* Flonac C
* Flonac N
* Kimitsu Chitosan F
* Kimitsu Chitosan F 2
* Kimitsu Chitosan H
* Kimitsu Chitosan L
* Kimitsu Chitosan M
* Kytex H
* Kytex M
* Poliglusam
* Sea Cure F
* Sea Cure Plus
FM6300000
Chitosan
9012-76-4
199701
2
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 957 gm/kg/58D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 15,555,1976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLORAL HYDRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
FM8750000
Chloral hydrate
302-17-0
1698497
4-01-00-03143 (Beilstein Handbook Reference)
199907
84
C2-H3-Cl3-O2
165.40
QYQXGGG
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aquachloral
* Bi 3411
* Chloraldurat
* Dormal
* 1,1-Ethanediol, 2,2,2-trichloro* Felsules
* Hydral
* Hydrate de chloral
* Kessodrate
* Lorinal
* Noctec
* Nycoton
* Nycton
* Phaldrone
*
*
*
*
*
*
*
*
*
*
*
*
*
Rectules
SK-Chloral hydrate
Somni SED
Somnos
Sontec
Tosyl
Trawotox
Trichloracetaldehyd-hydrat
Trichloroacetaldehyde hydrate
Trichloroacetaldehyde monohydrate
1,1,1-Trichloro-2,2-dihydroxyethane
1,1,1-Trichloro-2,2-ethanediol
2,2,2-Trichloro-1,1-ethanediol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - convulsions or effect on seizure threshold
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.11932- Volume(issue)/page/year:
131,787,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - coma
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
34,97,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 219 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
34,101,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 960 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptions
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
34,101,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 465 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - coma
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
223,269,1988
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Gastrointestinal - nausea or vomiting
REFERENCE :
PHBTH* "Pharmacology: Basis of Therapy," 3rd ed., Goodman, L.S., ed.,
New
York, Macmillan Pub. Co., 1967 Volume(issue)/page/year: 3,132,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - arrhythmias (including changes in conduction)
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
2,994,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Human - child
39 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
34,101,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 88 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
34,101,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 48 mg/kg/6H-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.361957Volume(issue)/page/year: 65,691,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 103 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 160 mg/kg/3D-I
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.361957Volume(issue)/page/year: 65,691,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 97 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.361957Volume(issue)/page/year: 65,691,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 479 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3030 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86
Volume(issue)/page/year:
A065,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 472 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 41,100,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,784,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 725 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),14,1970
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1114,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 106,444,1952
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 580 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 10,665,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - excitement
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 38,65,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 850 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),14,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(V/O
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 78,340,1943
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen
Institut
der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
Volume(issue)/page/year: -,-,1936
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Mammal - cat
400 mg/kg
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 78,340,1943
1909/10-
&
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 132,214,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 18,61,1916
(Berlin,
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 63,453,1938
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),14,1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Rectal
Rodent - rabbit
1 gm/kg
(V/O
TOXIC EFFECTS :
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 132,214,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 940 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),14,1970
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraarterial
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Oral
: Amphibian - frog
DOSE/DURATION
: 938 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 8,77,1901
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cattle
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cattle
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Mammal - cattle
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15120 mg/kg/90D-C
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 15,217,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 210 mg/kg/30W-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(3),14,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1413 mg/kg/90D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
6,137,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2016 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 44,137,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1440 mg/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 44,137,1982
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CDPRD4 Cancer Detection and Prevention. (Alan R. Liss, Inc., 41 E. 11th
St., New York, NY 10003) V.11976- Volume(issue)/page/year:
9,279,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 960 mg/kg/1W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
9,177,1955
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 13 gm/kg
SEX/DURATION
: female 3 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
6,137,1984
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 1 mg/plate
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2 mg/plate
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
30,9,1980
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
322,111,1994
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 15 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
141,19,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 5 mg/plate
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
30,9,1980
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
155,105,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 200 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
292,83,1993
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Non-mammalian species Cells - not otherwise
specified
DOSE/DURATION
: 100 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
45,215,1974
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Non-mammalian species Cells - not otherwise
specified
DOSE/DURATION
: 100 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
45,215,1974
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 18,1687,1997
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
334,1,1995
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 54 mg/L
REFERENCE :
AGTQAH Annales de Genetique. (Expansion Scientifique Francaise, 15 rue
Saint-Benoit, F-75278, Paris Cedex 06, France) V.11958Volume(issue)/page/year: 24,105,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,57,1993
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 41 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
323,81,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1250 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,265,1998
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 82700 ug/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,695,1984
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,265,1998
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
141,19,1984
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 80 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,71,1993
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,7,1995
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 165 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,47,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,47,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,29,1993
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,245,1995
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,245,1995
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,245,1995
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84490
No. of Facilities: 1191 (estimated)
No. of Industries: 3
No. of Occupations: 10
No. of Employees: 10916 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84490
No. of Facilities: 264 (estimated)
No. of Industries: 4
No. of Occupations: 11
No. of Employees: 11278 (estimated)
No. of Female Employees: 8131 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-aneuploidy; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-recombination; N
crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat;
Mammalian
micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
NTP Carcinogenesis studies; on test (two year studies), May 1999
CHLORAMPHENICOL
RTECS NUMBER
CHEMICAL NAME
: AB6825000
: Acetamide,
2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-pnitrophenethyl)-, D-(-)-threoCAS REGISTRY NUMBER
: 56-75-7
BEILSTEIN REFERENCE NO. : 2225532
REFERENCE
: 4-13-00-02742 (Beilstein Handbook Reference)
LAST UPDATED
: 199707
DATA ITEMS CITED
: 96
MOLECULAR FORMULA
: C11-H12-Cl2-N2-O5
MOLECULAR WEIGHT
: 323.15
WISWESSER LINE NOTATION : WNR DYQY1QMVYGG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Acetamide,
2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)* Acetamide,
2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-,
(R-(R*,R*))* Alficetyn
* Ambofen
* Amphenicol
* Amphicol
* Amseclor
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Anacetin
Aquamycetin
Austracol
Biocetin
Biophenicol
CAF (pharmaceutical)
CAM
CAP
Catilan
Chemicetin
Chemicetina
Chlomin
Chlomycol
Chloramex
Chloramfenikol
Chloramphenicol
D-Chloramphenicol
D-threo-Chloramphenicol
D-(-)-threo-Chloramphenicol
Chloramsaar
Chlorasol
Chlora-tabs
Chloricol
Chlornitromycin
Chloroamphenicol
Chlorocaps
Chlorocid
Chlorocide
Chlorocidin C
Chlorocidin C tetran
Chlorocid S
Chlorocol
Chloroject L
Chloromax
Chloromycetin
Chloromycetny
Chloronitrin
Chloroptic
Chloro-25 vetag
Chlorovules
Cidocetine
Ciplamycetin
Cloramficin
Cloramicol
Cloramidina
Cloroamfenicolo
Clorocyn
Cloromisan
Clorosintex
Comycetin
CPh
Cylphenicol
Desphen
Detreomycine
D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol
D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
D-(-)-threo-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl))-p-nitrop
henethylacetamide
*
D-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylet
hyl)acetamide
* D-threo-N-(1,1'-Dihydroxy-1-p-nitrophenylisopropyl)dichloroacetamide
* Doctamicina
* Econochlor
* Embacetin
* Emetren
* Enicol
* Enteromycetin
* Erbaplast
* Ertilen
* Farmicetina
* Fenicol
* Globenicol
* Glorous
* Halomycetin
* Hortfenicol
* I 337A
* Intramycetin
* Isicetin
* Ismicetina
* Isophenicol
* Isopto fenicol
* Juvamycetin
* Kamaver
* Kemicetina
* Kemicetine
* Klorita
* Klorocid S
* Leukomyan
* Leukomycin
* Levomicetina
* Levomycetin
* Loromisin
* Mastiphen
* Mediamycetine
* Micloretin
* Microcetina
* Mychel
* Mycinol
* NCI-C55709
* D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol
* D-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol
* Normimycin V
* Novochlorocap
* Novomycetin
* Novophenicol
* NSC 3069
* Oftalent
* Oleomycetin
* Opclor
* Ophthochlor
* Otachron
* Otophen
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Pantovernil
Paraxin
Pentamycetin
Quemicetina
Rivomycin
Romphenil
Septicol
Sificetina
Sintomicetina
Sintomicetine R
Stanomycetin
Synthomycetin
Synthomycetine
Tevcocin
Tifomycin
Tifomycine
Treomicetina
U-6062
Unimycetin
Veticol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 440 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
234,149,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Vascular - shock
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
234,149,1975
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE/DURATION
:
TOXIC EFFECTS :
Liver - other changes
TDLo - Lowest published toxic dose
Unreported
Human - child
250 mg/kg/10D
Blood - hemorrhage
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11962Volume(issue)/page/year: 14,499,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 30 mg/kg/3D-I
TOXIC EFFECTS :
Cardiac - cardiac output
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.11932- Volume(issue)/page/year:
103,487,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 250 mg/kg/2D
TOXIC EFFECTS :
Vascular - change in plasma or blood volume
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
262,787,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 200 mg/kg/4D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Blood - eosinophilia
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,555,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 10,3,1955
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1811 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
9,445,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 171 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 5,1,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65.
For publisher information, see PJPPAA. Volume(issue)/page/year:
14,21,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et
al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,493,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
55,425,1948
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >101 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 10,3,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 9,21,1954
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg/60D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(4),45,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17416 mg/kg/4W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 33600 mg/kg/14D-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
86,47,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 960 mg/kg/4D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and
Medical
Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.30-V.32,
1985-1987 Volume(issue)/page/year: 30,449,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2800 mg/kg/2W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - other changes
Related to Chronic Data - death
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 6400 mg/kg/3W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - guinea pig
2100 mg/kg/2W-C
Nutritional and Gross Metabolic - other changes
Related to Chronic Data - death
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
28,943,1949
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 300 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - changes in bone marrow (not otherwise specified)
Blood - leukemia
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
277,1003,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg/5W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
41,3478,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1680 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - aplastic anemia
Blood - leukemia
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
277,1003,1967
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 434 mg/kg/W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - aplastic anemia
Blood - leukemia
REFERENCE :
ACHAAH Acta Haematologica. (S. Karger Pub., Inc., 79 Fifth Ave., New
York,
NY 10003) V.11948- Volume(issue)/page/year: 66,267,1981
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 23 gm/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 12,291,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2500 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy,
Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR)
V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 60(5),25,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2500 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy,
Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR)
V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 60(5),25,1971
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2 gm/kg
female 8 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,667,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 35,1649,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2400 mg/kg
SEX/DURATION
: female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
VHAGAS Verhandlungen der Anatomischen Gesellschaft. (VEB Gustav Fischer
Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.) V.11887Volume(issue)/page/year: 71,623,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3500 mg/kg
SEX/DURATION
: female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City
Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher
information, see OIGZDE. Volume(issue)/page/year: 14,107,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
3500 mg/kg
female 6-10 day(s) after conception
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City
Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher
information, see OIGZDE. Volume(issue)/page/year: 14,107,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: female 10-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.11967Volume(issue)/page/year:
27,291,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5500 mg/kg
SEX/DURATION
: female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,667,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7 gm/kg
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,667,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
6 gm/kg
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,667,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 175 mg/kg
SEX/DURATION
: female 15-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall,
Oxford OX3 OBW, UK) V.91970- Volume(issue)/page/year: 13,233,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 gm/kg
SEX/DURATION
: female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
VHAGAS Verhandlungen der Anatomischen Gesellschaft. (VEB Gustav Fischer
Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.) V.11887Volume(issue)/page/year: 67,551,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 4 gm/kg
SEX/DURATION
: female 8-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,667,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 4 gm/kg
SEX/DURATION
: female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,667,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2700 mg/kg
SEX/DURATION
: female 11-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,353,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2700 mg/kg
SEX/DURATION
: female 2-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,353,1970
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 mmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 78,151,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 271,385,1978
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: DNA repair
: Bacteria - Escherichia coli
: 6 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 2 mmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 78,151,1977
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 8 mg/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
77,10,1959
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 2 gm/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
115,786,1973
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 gm/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH,
Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.11960Volume(issue)/page/year: 12,583,1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 189,73,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
74,113,1980
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Microorganism - not otherwise specified
: 1200 mg/L
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.)
1930-73. For publisher information, see AMICCW.
Volume(issue)/page/year:
81,1,1972
V.1-94,
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Protozoa - Euglena gracilis
DOSE/DURATION
: 3300 umol/L
REFERENCE :
CYTZAM Cytobiologie. (Stuttgart, Fed. Rep. Ger.) V.1-18, 1969-79. For
publisher information, see EJCBDN. Volume(issue)/page/year: 9,280,1974
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 5 mg
REFERENCE :
PISCAD Proceedings of the Indian Science Congress. (Indian Science
Congress
Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India) 1st- 1914Volume(issue)/page/year: 54,408,1967
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,65,1991
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Bone marrow
DOSE/DURATION
: 1500 umo/L
REFERENCE :
46GFA5 "Safety Problems Related to Chloramphenicol and Thiamphenicol
Therapy," Najean, Y., et al., eds., New York, Raven Press, 1981
Volume(issue)/page/year: -,17,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,207,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,1829,1973
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Cytogenetic analysis
: Human Lymphocyte
: 500 mg/L
REFERENCE :
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 7,305,1969
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1600 umol/L
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese
Journal
of Pharmacology. (China International Book Trading Corp., POB 2820,
Beijing, Peop. Rep. China) V.11980- Volume(issue)/page/year:
10,543,1989
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Lung
DOSE/DURATION
: 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,65,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,65,1991
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,65,1991
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat HeLa cell
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
4,874,1967
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval
Rd.,
London NW1 7DX, UK) V.11955- Volume(issue)/page/year: 21,60,1975
TYPE OF TEST
ROUTE OF EXPOSURE
: Cytogenetic analysis
: Parenteral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St.,
London
WC1A 1LU, UK) V.11966- Volume(issue)/page/year: 4,277,1973
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 30 mg/L
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.381949Volume(issue)/page/year: 74,1385,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Mammal - domestic Leukocyte
DOSE/DURATION
: 500 ug/L
REFERENCE :
RVMVAH Revue de Medecine Veterinaire (Toulouse). (Ecole Nationale
Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France)
V.89(2)1937- Volume(issue)/page/year: 126,1611,1975
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Mammal - pig Leukocyte
DOSE/DURATION
: 50 ug/L
REFERENCE :
RVMVAH Revue de Medecine Veterinaire (Toulouse). (Ecole Nationale
Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France)
V.89(2)1937- Volume(issue)/page/year: 126,1611,1975
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Mammal - cattle Fibroblast
DOSE/DURATION
: 5 mg/L
REFERENCE :
RVTSA9 Research in Veterinary Science. (British Veterinary Assoc., 7
Mansfield St., London W1M OAT, UK) V.11960Volume(issue)/page/year:
52,256,1992
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Mammal - cattle Lymphocyte
DOSE/DURATION
: 5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,11,1993
*** REVIEWS ***
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 10,85,1976
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 50,169,1990
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 10,85,1976
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 50,169,1990
IARC Cancer Review:Group 2A
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 50,169,1990
TOXICOLOGY REVIEW
PLMJAP Pahlavi Medical Journal. (Shiraz, Iran)
Volume(issue)/page/year: 6,160,1975
V.1-9, 1970-78.
TOXICOLOGY REVIEW
CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103)
Volume(issue)/page/year: 10(Pt 1),283,1973
V.1-11, 1963-76.
TOXICOLOGY REVIEW
PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W.
Washington Sq., Philadelphia, PA 19105) V.11954Volume(issue)/page/year: 8,413,1961
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84396
No. of Facilities: 165 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 11365 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84396
No.
No.
No.
No.
No.
of
of
of
of
of
Facilities: 2358 (estimated)
Industries: 3
Occupations: 19
Employees: 35571 (estimated)
Female Employees: 23544 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; E coli polA
without S9
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; B
subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLORANIL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DK6825000
p-Benzoquinone, 2,3,5,6-tetrachloro118-75-2
199710
14
C6-Cl4-O2
245.86
L6V DVJ BG CG EG FG
Agricultural Chemical
Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 1,4-Benzoquinone, 2,3,5,6-tetrachloro* Chloranil
* Dow Seed Disinfectant No. 5
* ENT 3,797
* G-25804
* G-444E
* Geigy-444E
* Reranil
* Spergon
* Spergon I
* Spergon technical
* Tetrachlorobenzoquinone
* Tetrachloro-p-benzoquinone
*
*
*
*
*
*
*
Tetrachloro-1,4-benzoquinone
2,3,5,6-Tetrachloro-p-benzoquinone
2,3,5,6-Tetrachloro-1,4-benzoquinone
2,3,5,6-Tetrachloro-2,5-cyclohexadiene-1,4-dione
Tetrachloroquinone
Tetrachloro-p-quinone
Vulklor
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,218,1966
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2485 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0530657-1
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For
publisher information, see CPBTAL. Volume(issue)/page/year: 3,337,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
Volume(issue)/page/year: 37(5),15,1972
V.1-
1936-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 gm/kg/8D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - change in clotting factors
Blood - changes in leukocyte (WBC) count
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,98,1943
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 66956 mg/kg/22W-C
TOXIC EFFECTS :
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,98,1943
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49915 mg/kg/67D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,98,1943
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 71 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1100 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
347,37,1995
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84201
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 41 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84201
No. of Facilities: 125 (estimated)
No. of Industries: 3
No. of Occupations: 8
No. of Employees: 2098 (estimated)
No. of Female Employees: 761 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLORDANE
RTECS NUMBER
CHEMICAL NAME
: PB9800000
: 4,7-Methanoindan,
1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydroCAS REGISTRY NUMBER
: 57-74-9
OTHER CAS REGISTRY NOS. : 39400-80-1
53637-13-1
BEILSTEIN REFERENCE NO. : 1915474
LAST UPDATED
: 199907
DATA ITEMS CITED
: 88
MOLECULAR FORMULA
: C10-H6-Cl8
MOLECULAR WEIGHT
: 409.76
WISWESSER LINE NOTATION : L C555 A IUTJ AG AG BG DG EG HG IG JG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aspon-chlordane
* BELT
* CD 68
* Chloordaan
* Chlordan
* Chlordane
* Chlorindan
* Chlor KIL
* Chlorodane
* Chlortox
* Clordan
* Clordano
* Cortilan-neu
* Dichlorochlordene
* Dowchlor
* ENT 9,932
* ENT 25,552-X
* HCS 3260
* Kilex lindane
* Kypchlor
* Latka 1068
* M 140
* 4,7-Methano-1H-indene,
1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro* NCI-C00099
* Octachlor
* Octachlorodihydrodicyclopentadiene
* 1,2,4,5,6,7,8,8-Octahydro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindan
* 1,2,4,5,6,7,8,8-Octachlor-2,3,3a,4,7,7a-hexahydro-4,7-methanoindane
* 1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
*
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
* 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-hexahydro-4,7-methylene indane
* Octachloro-4,7-methanohydroindane
* Octachloro-4,7-methanotetrahydroindane
* 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane
* 1,2,4,5,6,7,8,8-Octachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indaan
* 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
* 1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-methyleneindane
* 1,2,4,5,6,7,8,8-Octachlor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indan
* Octa-klor
* Oktaterr
* OMS 1437
* Ortho-klor
* 1,2,4,5,6,7,8,8-Ottochloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indano
* RCRA waste number U036
* SD 5532
* Shell SD-5532
* Starchlor
* Synklor
* TAT chlor 4
* Termi-ded
* Topichlor 20
* Topiclor
* Topiclor 20
* Toxichlor
* Unexan-koeder
* Velsicol 1068
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 3071 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
20,291,1983
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Liver - fatty liver degeneration
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 120 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Gastrointestinal - gastritis
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 428 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,648,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 17,614,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 690 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)
V.481915- Volume(issue)/page/year: 157,1835,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 343 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,443,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,19,1966
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04876
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 100 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 8(4),30,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,226,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und
Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHOAX Archives of Industrial Hygiene and Occupational Medicine.
(Chicago,
IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
Volume(issue)/page/year: 1,13,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 1720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,159,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,226,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept.,
Midland, MI 48640) V.11945- Volume(issue)/page/year: 35,25,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - domestic
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan)
V.1-
1950-
Volume(issue)/page/year: 32,471,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,226,1966
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: >20 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
9,139,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE/DURATION
:
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
AMPLAO AMA Archives of
For
publisher information,
TDLo - Lowest published toxic dose
Oral
Rodent - rat
410 mg/kg/39W-C
Pathology.
see APLMAS.
(Chicago, IL)
V.50(4)-69, 1950-60.
Volume(issue)/page/year: 64,614,1957
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28200 ug/m3/8H/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 28,327,1989
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
660 mg/kg/15D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 7,197,1953
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6512 mg/kg/58W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 7,197,1953
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5475 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,357,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/m3/8H/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 28,327,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 504 mg/kg/12W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A99,1980
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2020 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-8,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3780 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-8,1977
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3360 ug/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(2),357,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 152 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,402,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7 mg/kg
SEX/DURATION
: female 15-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd.,
Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.341968Volume(issue)/page/year:
49,311,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3040 ug/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 35,204,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 168 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A18,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 168 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,23A,1979
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 3050 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1182,193,1987
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 54 pmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
118,61,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,161,1977
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
52,221,1983
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1260 mg/kg/6W
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 9,387,1988
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 35 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
301,33,1993
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
19,369,1977
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,45,1979
IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,146,1987
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,115,1991
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,45,1979
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,115,1991
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,115,1991
TOXICOLOGY REVIEW
CNDQA8 Cahiers de Nutrition et de Dietetique.
(Editions Meteore, 42, rue
du
Louvre, 75001 Paris, France)
10(3),43,1975
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
V.1-
1966-
Volume(issue)/page/year:
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,44,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin JAN 1993
OEL-AUSTRIA: MAK 0.5 mg/m3, Skin, Suspected Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin;Carcinogen JAN 1993
OEL-AUSTRIA:TWA 0.5 mg/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.5 mg/m3, Skin, JAN1999
OEL-BELGIUM:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-GERMANY:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993
OEL-INDIA:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 0.01 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.5 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLORDANE-air:10H CA TWA 0.5 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/168709/AS
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Chlordane, 5510
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-8,1977
NCI Carcinogenesis Bioassay (feed);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-8,1977
CHLORINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
FO2100000
Chlorine
7782-50-5
199907
65
Cl2
70.90
G2
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Bertholite
* Chloor
* Chlor
* Chlore
* Chlorine
* Chlorine mol.
* Cloro
* Molecular chlorine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2530 mg/m3/30M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - emphysema
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
28ZOAH "Chemicals in War," Prentiss, A.M., New York, McGraw Hill Book
Co.,
1937 Volume(issue)/page/year: -,150,1937
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 500 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 293 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 137 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 800 ppm/30M
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 14,65,1919
V.1-
1909/10-
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3200 ppm/3H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AHYGAJ Archiv fuer Hygiene. (Munich, Fed. Rep. Ger.) V.1-100,
1883-1928.
For publisher information, see ZHPMAT. Volume(issue)/page/year:
7,231,1887
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 500 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3312 mg/kg/92D-C
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,401,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 109 gm/kg/2Y-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in other cell count (unspecified)
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982-
Volume(issue)/page/year:
21,427,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 ppm/6H/6W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
49,77,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7568 mg/kg/28D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
21,423,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/2W-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 2,1161,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9100 ppb/6H/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
71,225,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 153 gm/kg/73W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - changes in ovarian weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
21,435,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9100 ppb/6H/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
71,225,1983
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5096 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-392,1992
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 2300 ppb/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571476
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
565 mg/kg
male 8 week(s) pre-mating
female 2 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,43A,1987
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1800 ug/L
REFERENCE :
OZSEDS Ozone: Science & Engineering. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.11979Volume(issue)/page/year:
8,217,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 20 ppm
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
6,375,1973
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg/5D (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,201,1985
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 2.9 mg/m3 (1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1.5 mg/m3 (0.5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 1 ppm (3 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,46,1971
OSHA PEL (Gen Indu):CL 1 ppm (3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 1 ppm (3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 1 ppm (3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 1 ppm (3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 1 ppm (3 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.5 ppm (1.5 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 1 ppm (3 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 0.5 ppm (1.5 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.5 ppm (1.5 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.5 ppm (1.5 mg/m3);STEL 1 ppm (3 mg/m3) JAN 1993
OEL-JAPAN: OEL 1 ppm (2.9 mg/m3), JAN1999
OEL-FINLAND:TWA 0.5 ppm (1.5 mg/m3);STEL 1 ppm (3 mg/m3) JAN 1993
OEL-GERMANY:TWA 0.5 ppm (1.5 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 1.5 mg/m3, MAC(STEL) 9 mg/m3, JAN1999
OEL-HUNGARY:STEL 1 mg/m3 JAN 1993
OEL-INDIA:TWA 1 ppm (3 mg/m3);STEL 3 ppm (9 mg/m3) JAN 1993
OEL-JAPAN:TWA 1 ppm (2.9 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (3 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (3 mg/m3) JAN 1993
OEL-RUSSIA:TWA 1 ppm;STEL 1 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.5 ppm (1.5 mg/m3);STEL 1 ppm (3 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.5 ppm (1.5 mg/m3);STEL 1 ppm (3 mg/m3) JAN 1993
OEL-THAILAND:TWA 1 ppm (3 mg/m3) JAN 1993
OEL-TURKEY:TWA 1 ppm (3 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (3 mg/m3);STEL 3 ppm (9 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLORINE-air:10H TWA 0.5 ppm;STEL 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 18040
No. of Facilities: 21429 (estimated)
No. of Industries: 169
No. of Occupations: 86
No. of Employees: 220544 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9656
No. of Facilities: 338 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 4768 (estimated)
No. of Female Employees: 1862 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 18040
No. of Facilities: 5343 (estimated)
No. of Industries: 70
No. of Occupations: 75
No. of Employees: 178105 (estimated)
No. of Female Employees: 20221 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Bromine and chlorine, 6011
NTP Carcinogenesis Studies (drinking);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-392,1992
NTP Carcinogenesis Studies (drinking);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-392,1992
(Research
OSHA ANALYTICAL METHOD #ID-101
CHLOROACETAMIDE (2-)
RTECS NUMBER
: AB5075000
CHEMICAL NAME
: Acetamide, 2-chloroCAS REGISTRY NUMBER
: 79-07-2
BEILSTEIN REFERENCE NO. : 0878191
REFERENCE
: 4-02-00-00490 (Beilstein Handbook Reference)
LAST UPDATED
: 199809
DATA ITEMS CITED
: 15
MOLECULAR FORMULA
: C2-H4-Cl-N-O
MOLECULAR WEIGHT
: 93.52
WISWESSER LINE NOTATION : ZV1G
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Chloracetamid
* Chloracetamide
* Chloroacetamide
* alpha-Chloroacetamide
* 2-Chloroacetamide
* 2-Chloroethanamide
* Mergal AF
* Microcide
* USAF DO-29
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 138 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 19,1073,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 155 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China
International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11915Suspended 1967-72. Volume(issue)/page/year: 58,462,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
100 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#03764
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 31 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China
International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11915Suspended 1967-72. Volume(issue)/page/year: 58,462,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 122 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China
International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11915Suspended 1967-72. Volume(issue)/page/year: 58,462,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1138 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - thyroid weight (goiter)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536952
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 960 mg/kg/30D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Cardiac - EKG changes not diagnostic of specified effects
Related to Chronic Data - death
REFERENCE :
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China
International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11915Suspended 1967-72. Volume(issue)/page/year: 58,462,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6 gm/kg/30D-I
TOXIC EFFECTS :
Blood - changes in spleen
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536947
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
210,255,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1156
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 90 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROACETIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
AF8575000
Acetic acid, chloro79-11-8
0605438
4-02-00-00474 (Beilstein Handbook Reference)
199907
27
C2-H3-Cl-O2
94.50
QV1G
Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acide chloracetique
* Acide monochloracetique
* Acidomonocloroacetico
* Chloracetic acid
* Chloroacetic acid
* alpha-Chloroacetic acid
* Chloroethanoic acid
* Kyselina chloroctova
* MCA
* Monochloorazijnzuur
* Monochloracetic acid
* Monochloressigsaeure
* Monochloroacetic acid
* Monochloroethanoic acid
* NCI-C60231
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(9),32,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - rat
180 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(9),32,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 41,113,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,303,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 116,154,1958
V.4-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9750 mg/kg/13W-I
TOXIC EFFECTS :
Cardiac - other changes
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-396,1992
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20800 ug/m3/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Blood - pigmented or nucleated red blood cells
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(9),32,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13 gm/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-396,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3840 mg/kg/16D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - ataxia
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-396,1992
(Research
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 20800 ug/m3/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Blood - pigmented or nucleated red blood cells
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(9),32,1974
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
53,695,1974
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 548 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
97,49,1982
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 400 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,143,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 160 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** REVIEWS ***
TOXICOLOGY REVIEW
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
11,13,1955
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.3 ppm;STEL 1 ppm;Skin JAN 1993
OEL-POLAND: MAC(TWA) 2 mg/m3, MAC(STEL) 4 mg/m3, JAN1999
OEL-SWEDEN: TWA 1 ppm (4 mg/m3), STEL 2 ppm (8 mg/m3), Skin, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 18070
No. of Facilities: 1196 (estimated)
No. of Industries: 9
No. of Occupations: 14
No. of Employees: 4726 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 18070
No. of Facilities: 265 (estimated)
No. of Industries: 12
No. of Occupations: 20
No. of Employees: 10912 (estimated)
No. of Female Employees: 1723 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Chloroacetic acid, 2008
NTP Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-396,1992
CHLOROACETIC ACID SODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
:
:
:
:
:
:
AG1400000
Acetic acid, chloro-, sodium salt
3926-62-3
199710
12
C2-H2-Cl-O2.Na
(Research
MOLECULAR WEIGHT
: 116.48
WISWESSER LINE NOTATION : QV1G &-NACOMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* Chloroacetic acid sodium salt
* Chloroctan sodny
* Dow defoliant
* Monoxone
* SMA
* SMCA
* Sodium monochloracetate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 95 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,78,1941
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 86,336,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 156 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,1047,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 99 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,78,1941
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(12),53,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,1047,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NVTMAF Nordisk Veterinaermedicin Danske Udgave. (Copenhagen, Denmark)
Volume(issue)/page/year: 13,271,1961
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - domestic
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Gastrointestinal - other changes
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
18,179,1961
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5400 mg/kg/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in leukocyte (WBC) count
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 67,171,1991
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROACETONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
UC0700000
2-Propanone, 1-chloro78-95-5
0605369
4-01-00-03215 (Beilstein Handbook Reference)
199712
17
C3-H5-Cl-O
92.53
G1V1
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Acetone, chloro* Acetonyl chloride
* A-Stoff
* Chloracetone
* Chloroacetone
* Chloroacetone
* 1-Chloro-2-ketopropane
* 1-Chloro-2-oxopropane
* Chloropropanone
* 1-Chloro-2-propanone
* Monochloracetone
* Monochloroacetone
* Tonite
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 605 ppm/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Skin and Appendages - hair
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
47,375,1986
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 262 ppm/1H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Skin and Appendages - hair
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
47,375,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 33,695,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 127 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Skin and Appendages - hair
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
47,375,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 92 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 33,695,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 141 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Skin and Appendages - hair
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
47,375,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 650 mg/kg/17D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - gastritis
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570898
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 6 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,1,1994
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 pph/6M
REFERENCE :
PREBA3 Proceedings of the Royal Society of Edinburgh, Section B.
(Edinburgh,
Scotland, UK) V.61-74, 1943-74. Volume(issue)/page/year:
62,284,1946/1947
*** REVIEWS ***
ACGIH TLV-CL 3.8 mg/m3 (1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5194
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 4354 (estimated)
No. of Female Employees: 729 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROACETONITRILE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
AL8225000
Acetonitrile, chloro107-14-2
0506028
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
4-02-00-00492 (Beilstein Handbook Reference)
199710
19
C2-H2-Cl-N
75.50
NC1G
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Chloracetonitrile
* alpha-Chloroacetonitrile
* 2-Chloroacetonitrile
* Chloromethyl cyanide
* Monochloroacetonitrile
* Monochloromethyl cyanide
* USAF KF-5
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 14 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,907,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,907,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 139 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
55,47,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 71 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4800 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,1065,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 30 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,289,1995
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 1250 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,289,1995
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 15 umol/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-246230
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 115 mg/kg
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 13,220,1993
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 79100 nmol/L
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,1065,1985
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 52,269,1991
IARC Cancer Review:Human No Available Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 52,269,1991
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 52,269,1991
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROACETOPHENONE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
AM6300000
Acetophenone, 2-chloro532-27-4
0507950
4-07-00-00641 (Beilstein Handbook Reference)
199907
55
C8-H7-Cl-O
154.60
G1VR
Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Chemical mace
* alpha-Chloroacetophenone
* omega-Chloroacetophenone
* 2-Chloroacetophenone
* alpha-Chloroacetophenone
* Chloromethyl phenyl ketone
* 2-Chloro-1-phenylethanone
* CN
* Ethanone, 2-chloro-1-phenyl* Mace (lacrimator)
* NCI-C55107
* Phenacyl chloride
* Phenylchloromethylketone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12%/6H
REACTION SEVERITY
: Moderate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,295,1970
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 12%/6H
REACTION SEVERITY
: Moderate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 mg
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,295,1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3 mg
REACTION SEVERITY
: Severe
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,295,1970
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 12%/6H
REACTION SEVERITY
: Moderate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 159 mg/m3/20M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,163,1969
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 93 mg/m3/3M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,199,1962
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 20 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
29,298,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
50 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,295,1970
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 417 mg/m3/15M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Kidney, Ureter, Bladder - other changes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 139 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD837-111
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 59 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 58(10),4,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD837-111
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 81 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Kidney, Ureter, Bladder - other changes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 118 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LCLo - Lowest published lethal concentration
Inhalation
Rodent - rabbit
465 mg/m3/20M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Kidney, Ureter, Bladder - other changes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 158 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 490 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - guinea pig
DOSE/DURATION
: 17 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
40,75,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 19 mg/m3/6H/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-379,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/m3/6H/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-379,1990
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 mg/m3/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
Skin and Appendages - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-379,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg/27W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
7,482,1953
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,59,1996
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 3 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-379,1990
(Research
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.32 mg/m3 (0.05 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 ppm (0.3 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,48,1971
OSHA PEL (Gen Indu):8H TWA 0.05 ppm (0.3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.05 ppm (0.3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.05 ppm (0.3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.05 ppm (0.3 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 ppm (0.3 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.05 ppm (0.3 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.05 ppm (0.32 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.05 ppm (0.3 mg/m3), JAN1999
OEL-FINLAND:STEL 0.05 ppm (0.3 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.05 ppm (0.3 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 ppm (0.3 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.05 ppm (0.3 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 ppm (0.3 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO alpha-CHLOROACETOPHENONE-air:10H TWA 0.05 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4754
No. of Facilities: 35 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 2294 (estimated)
No. of Female Employees: 1412 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (inhalation);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-379,1990
NTP Carcinogenesis Studies (inhalation);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-379,1990
(Research
CHLOROACETOPHENONE (4-)
RTECS NUMBER
: KM5600000
CHEMICAL NAME
: Ethanone, 1-(4-chlorophenyl)CAS REGISTRY NUMBER
: 99-91-2
BEILSTEIN REFERENCE NO. : 0386014
REFERENCE
: 4-07-00-00639 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C8-H7-Cl-O
MOLECULAR WEIGHT
: 154.60
WISWESSER LINE NOTATION : GR DV1
COMPOUND DESCRIPTOR
: Human
SYNONYMS/TRADE NAMES :
* Acetophenone, 4'-chloro* p-Acetylchlorobenzene
* 4-Acetylchlorobenzene
* 4'-Chloroacetophenone
* 1-(4-Chlorophenyl)ethanone
* p-Chlorophenyl methyl ketone
* 4-Chlorophenyl methyl ketone
* Methyl p-chlorophenyl ketone
* Methyl 4-chlorophenyl ketone
* USAF DO-1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Human
1 mg/m3/1M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
27ZZA9 "Manual of Pharmacology and Its Applications to Therapeutics and
Toxicology," 8th ed., Sollman, T., Philadelphia, W.B. Saunders Co., 1957
Volume(issue)/page/year: 8,192,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1207 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
31,317,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1752 mg/m3/15M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 14,411,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 87600 ug/m3/15M/10D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Endocrine - hyperglycemia
Endocrine - changes in spleen weight
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 14,411,1994
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7067
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLOROACETYL CHLORIDE
RTECS NUMBER
: AO6475000
CHEMICAL NAME
: Acetyl chloride, chloroCAS REGISTRY NUMBER
: 79-04-9
BEILSTEIN REFERENCE NO. : 0605439
REFERENCE
: 4-02-00-00488 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 27
MOLECULAR FORMULA
: C2-H2-Cl2-O
MOLECULAR WEIGHT
: 112.94
WISWESSER LINE NOTATION : GV1G
SYNONYMS/TRADE NAMES :
* Chloracetyl chloride
* Chlorid kyseliny chloroctove
* Chloroacetic acid chloride
* Chloroacetic chloride
* Chloroacetyl chloride
* Chlorure de chloracetyle
* Monochloroacetyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 208 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year:
5,123(89),1986
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,607,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 662 mg/kg
TOXIC EFFECTS :
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(2),90,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(2),90,1989
(V/O
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year:
5,123(89),1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04538
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year:
5,123(89),1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 ppm/6H/4W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536493
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 ppm/6H/4W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536493
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 5 ppm/6H/4W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536493
*** REVIEWS ***
ACGIH TLV-STEL 0.69 mg/m3 (0.15 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.23 mg/m3 (0.05 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 ppm (0.2 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.05 ppm (0.2 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.05 ppm (0.23 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.05 ppm (0.2 mg/m3), JAN1999
OEL-THE NETHERLANDS:TWA 0.05 ppm (0.2 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.05 ppm (0.24 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 ppm (0.2 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLOROACETYL CHLORIDE-air:10H TWA 0.05 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1131
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 66 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1131
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 4354 (estimated)
No. of Female Employees: 729 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROAMINOTOLUENE (2,4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
XU5111000
p-Toluidine, 3-chloro95-74-9
0636511
4-12-00-01985 (Beilstein Handbook Reference)
199904
15
C7-H8-Cl-N
141.61
ZR CG D1
Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 1-Amino-3-chloro-4-methylbenzene
* 4-Amino-2-chlorotoluene
* Benzenamine, 3-chloro-4-methyl* 2-Chloro-4-aminotoluene
* 3-Chloro-4-methylaniline
* 3-Chloro-p-toluidine
* DRC 1347
* NCI-C02040
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 325 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,517,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,517,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
Volume(issue)/page/year: NCI-E-C-72-3252,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944)
V.1-
1973-
Volume(issue)/page/year: 12,355,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 2400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 375 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,189,1994
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-145,1978
CHLOROANILINE (3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
BX0350000
Aniline, m-chloro108-42-9
199907
26
C6-H6-Cl-N
127.58
ZR CG
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* m-Aminochlorobenzene
* 1-Amino-3-chlorobenzene
* Benzenamine, 3-chloro* 3-Chlooranilinen
* m-Chloraniline
* m-Chloroaniline
* 3-Chloroaniline
* 3-Chlorobenzenamine
* m-Chlorophenylamine
* 3-Chlorophenylamine
* 3-Cloroaniline
* Fast Orange GC Base
* Orange GC Base
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 256 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(12),6,1966
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555316
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,34,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 334 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(5),29,1969
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 550 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,34,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
200 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 244,387,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 223 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(5),29,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For publisher information, see ZHPMAT.
Volume(issue)/page/year: 110,12,1933
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(12),6,1966
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - guinea pig
100 mg/kg
(V/O
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg/13W-I
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
Blood - changes in erythrocyte (RBC) count
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(7),13,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6125 mg/kg/35W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(12),6,1966
(V/O
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14560 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - pigmented or nucleated red blood cells
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 14,394,1994
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 200 mg/L
REFERENCE :
CJMIAZ Canadian Journal of Microbiology. (National Research Council of
Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada)
V.11954- Volume(issue)/page/year: 16,369,1970
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 300 ug/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 39,359,1986
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-POLAND: TWA 3 mg/m3, STEL 10 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4029
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 851 (estimated)
No. of Female Employees: 187 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0193-8687
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Toxicity studies, RPT# TOX-43, May 1999
CHLOROANILINE (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
BX0700000
Aniline, p-chloro106-47-8
199907
47
C6-H6-Cl-N
127.58
ZR DG
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1-Amino-4-chlorobenzene
* 4-Aminochlorobenzene
* 4-Amino-1-chlorobenzene
* Aniline, 4-chloro* Benzeneamine, 4-chloro
* 4-Chloranilin
* p-Chloraniline
* p-Chloroaniline
* 4-Chloroaniline
* 4-Chlorobenzenamine
* p-Chlorophenylamine
* 4-Chlorophenylamine
* NCI-C02039
* RCRA waste number P024
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,610,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,610,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(7),13,1967
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
(V/O
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2340 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546450
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 15,447,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 15,447,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
Volume(issue)/page/year: NCI-E-C-72-3252,1973
TYPE OF TEST
: LC12 - Lethal Concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,34,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 244,387,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 239 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(5),29,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
Blood - other hemolysis with or without anemia
REFERENCE :
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For publisher information, see ZHPMAT.
Volume(issue)/page/year: 110,12,1933
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 360 mg/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,34,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 12,355,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3367 mg/kg/13W-I
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
Blood - changes in erythrocyte (RBC) count
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(7),13,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
30 ug/m3/24H/80D-C
(V/O
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(4),44,1970
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/4H/17W-I
TOXIC EFFECTS :
Behavioral - aggression
Blood - methemoglobinemia-carboxyhemoglobin
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(5),29,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg/10D-I
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 35,108,1972
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9270 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
29,119,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5150 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
29,119,1991
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Vascular - tumors
Blood - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-189,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Blood - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
25,619,1987
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 328 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Vascular - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-189,1979
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST
TEST SYSTEM
: DNA repair
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 200 mg/L
REFERENCE :
CJMIAZ Canadian Journal of Microbiology. (National Research Council of
Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada)
V.11954- Volume(issue)/page/year: 16,369,1970
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 14500 ng/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
97,359,1982
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 15600 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 800 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,21,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1520 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
3,193,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 ug/L
REFERENCE :
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.11959Volume(issue)/page/year: 58,243,1981
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,305,1993
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,305,1993
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,305,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: Skin, Carcinogen, JAN1999
OEL-POLAND: TWA 3 mg/m3, STEL 10 mg/m3, JAN1999
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; E coli polA without
S9
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-189,1979
CHLOROBENZALDEHYDE (4-)
RTECS NUMBER
: CU5076000
CHEMICAL NAME
: Benzaldehyde, p-chloroCAS REGISTRY NUMBER
: 104-88-1
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C7-H5-Cl-O
MOLECULAR WEIGHT
: 140.57
SYNONYMS/TRADE NAMES :
* Benzaldehyde, 4-chloro* p-Chlorobenzaldehyde
* 4-Chlorobenzaldehyde
* p-Chlorobenzenecarboxaldehyde
* 4-Chlorobenzenaldehyde
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1575 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),50,1987
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >473 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),50,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),50,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4033
No. of Facilities: 50 (estimated)
No. of Industries: 3
No. of Occupations: 21
No. of Employees: 6571 (estimated)
No. of Female Employees: 916 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBENZAMIDE (4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Benzamide, p-chloro* p-Chlorobenzamide
* 4-Chlorobenzamide
* p-Chlorobenzoic acid
CV2443811
Benzamide, 4-chloro619-56-7
0774622
4-09-00-00985 (Beilstein Handbook Reference)
199709
1
C7-H6-Cl-N-O
155.59
Drug
amide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 28,335,1994
CHLOROBENZENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CZ0175000
Benzene, chloro108-90-7
199907
71
C6-H5-Cl
112.56
GR
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzene chloride
* Chloorbenzeen
* Chlorbenzene
* Chlorbenzol
* Chlorobenzen
* Chlorobenzene
* Chlorobenzenu
* Clorobenzene
* MCB
* Monochloorbenzeen
* Monochlorbenzene
* Monochlorbenzol
* Monochlorobenzene
* Monoclorobenzene
* NCI-C54886
* Phenyl chloride
* Tetrosin SP
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
1110 mg/kg
No.1-
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University,
Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.11949Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2965 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521601
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1655 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,105,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,34,1982
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 20(8),19,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 515 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental
Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.11959Volume(issue)/page/year: 10,172,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2B,3603,1981
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A180-198
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,34,1982
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986
Volume(issue)/page/year: 6,271,1991
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4100 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
REFERENCE :
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La
Suisse
Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.11881Volume(issue)/page/year: 16,449,1896
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 10 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
14 gm/kg/14D-I
(V/O
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,745,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - peptidases
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,745,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27300 ug/kg/39W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - eosinophilia
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(10),15,1968
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/60D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 30(3),8,1965
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ppm/7H/24W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555046
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16250 mg/kg/13W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney, Ureter, Bladder - other changes in urine composition
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,745,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 17712 mg/kg/93D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,393,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 441 mg/kg/63W-I
TOXIC EFFECTS :
Gastrointestinal - gastritis
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 20(7),7,1955
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ppm/7H/24W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555046
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 441 mg/kg/63W-I
TOXIC EFFECTS :
Gastrointestinal - gastritis
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 20(7),7,1955
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 61800 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Blood - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-261,1985
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 75 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
76,365,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
210 ppm/6H
female 6-15 day(s) after conception
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
76,365,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 590 ppm/6H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
76,365,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 10 ppm/6H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
76,365,1984
** MUTATION DATA **
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1000 ppm
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 225 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EMMUEG Environmental
: Mutation in microorganisms
: Rodent - mouse Lymphocyte
: 70 mg/L
and Molecular Mutagenesis.
(Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003)
12,85,1988
V.10-
1987-
Volume(issue)/page/year:
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
25,302,1995
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,85,1988
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 300 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 46 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 75 ppm (350 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,49,1971
OSHA PEL (Gen Indu):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 1 ppm JAN 1993
OEL-AUSTRIA: MAK 50 ppm (230 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 50 ppm (230 mg/m3) JAN 1993
OEL-DENMARK: TWA 10 ppm (46 mg/m3), JAN1999
OEL-BELGIUM:TWA 75 ppm (345 mg/m3) JAN 1993
OEL-FRANCE: VME 10 ppm, JAN1999
OEL-JAPAN: OEL 10 ppm (46 mg/m3), JAN1999
OEL-FINLAND:TWA 50 ppm (230 mg/m3);STEL 75 ppm (345 mg/m3) JAN 1993
OEL-GERMANY:TWA 50 ppm (230 mg/m3) JAN 1993
OEL-POLAND: TWA 50 mg/m3, STEL 150 mg/m3, JAN1999
OEL-INDIA:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (230 mg/m3);STEL 100 ppm (460 mg/m3) JAN 1993
OEL-TURKEY:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (230 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 18190
No. of Facilities: 1965 (estimated)
No. of Industries: 36
No. of Occupations: 46
No. of Employees: 46734 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 18190
No. of Facilities: 912 (estimated)
No. of Industries: 24
No. of Occupations: 35
No. of Employees: 18050 (estimated)
No. of Female Employees: 3881 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NTP Carcinogenesis Studies (gavage);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-261,1985
NTP Carcinogenesis Studies (gavage);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-261,1985
CHLOROBENZENESULFONAMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
(4-)
: DB1400000
: Benzenesulfonamide, p-chloro: 98-64-6
(Research
(Research
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
1308891
4-11-00-00115 (Beilstein Handbook Reference)
199709
5
C6-H6-Cl-N-O2-S
191.64
ZSWR DG
Agricultural Chemical
Drug
SYNONYMS/TRADE NAMES :
* ADD 55051
* Benzenesulfonamide, 4-chloro* p-Chlorobenzenesulfamide
* p-Chlorobenzenesulfonamide
* 4-Chlorobenzenesulfonamide
* p-Chlorophenylsulfonamide
* 4-Chlorophenylsulfonamide
* USAF MA-3
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,20,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
21,193,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBENZENESULFONYL CHLORIDE (4-)
RTECS NUMBER
: DB8925000
CHEMICAL NAME
: Benzenesulfonyl chloride, p-chloroCAS REGISTRY NUMBER
: 98-60-2
BEILSTEIN REFERENCE NO. : 0511583
REFERENCE
: 4-11-00-00114 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C6-H4-Cl2-O2-S
MOLECULAR WEIGHT
: 211.06
WISWESSER LINE NOTATION : WSGR DG
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzenesulfonyl chloride, 4-chloro* p-Chlorbenzensulfochlorid
* Chlorid kyseliny p-chlorbensulfonove
* p-Chlorobenzenesulfonyl chloride
* 4-Chlorobenzenesulfonyl chloride
* p-Chlorophenylsulfonyl chloride
* 4-Chlorophenylsulfonyl chloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1071,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1071,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1071,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 7,774,1955
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLOROBENZOIC ACID (2-)
RTECS NUMBER
: DG4976000
CHEMICAL NAME
: Benzoic acid, o-chloroCAS REGISTRY NUMBER
: 118-91-2
BEILSTEIN REFERENCE NO. : 0907340
REFERENCE
: 4-27-00-07875 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C7-H5-Cl-O2
MOLECULAR WEIGHT
: 156.57
WISWESSER LINE NOTATION : QVR BG
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzoic acid, 2-chloro* 2-Cba
* o-Chlorobenzoic acid
* 2-Chlorobenzoic acid
* Kyselina o-chlorbenzoova
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,576,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,576,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,18,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83210
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 249 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBENZOIC ACID (3-)
RTECS NUMBER
: DG4975990
CHEMICAL NAME
: Benzoic acid, m-chloroCAS REGISTRY NUMBER
: 535-80-8
BEILSTEIN REFERENCE NO. : 0907218
REFERENCE
: 4-27-00-07875 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H5-Cl-O2
MOLECULAR WEIGHT
: 156.57
WISWESSER LINE NOTATION : QVR CG
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acido m-clorobenzoico
* Benzoic acid, 3-chloro* m-Chlorobenzoic acid
* 3-Chlorobenzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBENZOIC ACID (4-)
RTECS NUMBER
: DG4976010
CHEMICAL NAME
: Benzoic acid, p-chloroCAS REGISTRY NUMBER
: 74-11-3
BEILSTEIN REFERENCE NO. : 0907196
REFERENCE
: 4-09-00-00973 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C7-H5-Cl-O2
MOLECULAR WEIGHT
: 156.57
WISWESSER LINE NOTATION : QVR DG
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acido p-clorobenzoico
* Benzoic acid, 4-chloro* p-Carboxychlorobenzene
* p-Chlorbenzoic acid
* p-Chlorobenzoic acid
* 4-Chlorobenzoic acid
* Chlorodracylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 21,794,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 23,724,1975
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLOROBENZOPHENONE (2-)
RTECS NUMBER
: PC4945633
CHEMICAL NAME
: Methanone, (2-chlorophenyl)phenylCAS REGISTRY NUMBER
: 5162-03-8
LAST UPDATED
: 199903
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C13-H9-Cl-O
MOLECULAR WEIGHT
: 216.67
SYNONYMS/TRADE NAMES :
* Benzophenone, 2-chloro* o-Chlorobenzophenone
* 2-Chlorobenzophenone
* 2-Chlorobenyl phenyl ketone
* (2-Chlorophenyl)phenylmethanone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0544006
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBENZYL CHLORIDE (2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
CZ0195000
Benzene, 1-chloro-2-(chloromethyl)611-19-8
0471700
REFERENCE
: 4-05-00-00816 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C7-H6-Cl2
MOLECULAR WEIGHT
: 161.03
SYNONYMS/TRADE NAMES :
* 2-Chlorobenzyl chloride
* o-Chlorobenzyl chloride
* 1-Chloro-2-(chloromethyl)benzene
* alpha,o-Dichlorotoluene
* alpha,2-Dichlorotoluene
* o,alpha-Dichlorotoluene
* Toluene, alpha,o-dichloro*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1140 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0990-1020
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0990-1020
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84023
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 20 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84023
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 4354 (estimated)
No. of Female Employees: 729 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBIPHENYL (4-)
RTECS NUMBER
: DV2080000
CHEMICAL NAME
: Biphenyl, 4-chloroCAS REGISTRY NUMBER
: 2051-62-9
LAST UPDATED
: 199710
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C12-H9-Cl
MOLECULAR WEIGHT
: 188.66
WISWESSER LINE NOTATION : GR DR
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 4-Chlorobiphenyl
* 4-Chloro-1,1'-biphenyl
* p-Chlorodiphenyl
* 4-Chlorodiphenyl
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35.
For
publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Biochemical - Enzyme
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
150 mg/kg/3D-I
inhibition, induction, or change in blood or tissue
levels - other esterases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
33,94,1975
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 15,563,1976
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROBUTANE (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
EJ6300000
Butane, 1-chloro109-69-3
1730909
4-01-00-00246 (Beilstein Handbook Reference)
199904
21
C4-H9-Cl
92.58
G4
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Butyl chloride
* n-Butyl chloride
* 1-Chlorobutane
* Chlorure de butyle
* NCI-C06155
* n-Propylcarbinyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) No.11918- Volume(issue)/page/year:
(7),105,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(3),11,1979
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,745,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Unreported
Rodent - guinea pig
8 gm/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) No.11918- Volume(issue)/page/year:
(7),105,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 364 mg/kg/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(3),11,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10500 mg/kg/14D-I
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-312,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-312,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 21 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
(Research
(Research
(Research
NTP-TR-312,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 65 gm/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-312,1986
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 13927 mg/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(3),11,1979
(V/O
** MUTATION DATA **
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-312,1986
(Research
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3168
No. of Facilities: 33 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 3202 (estimated)
No. of Female Employees: 880 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-312,1986
(Research
CHLOROBUTANE (2-)
RTECS NUMBER
: EJ6475000
CHEMICAL NAME
: Butane, 2-chloroCAS REGISTRY NUMBER
: 78-86-4
BEILSTEIN REFERENCE NO. : 1718770
REFERENCE
: 3-01-00-00277 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C4-H9-Cl
MOLECULAR WEIGHT
: 92.58
WISWESSER LINE NOTATION : GY2&1
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* sec-Butyl chloride
* 2-Chlorobutane
* 1-Methylpropyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311)
30,470,1969
V.19-
1958-
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3240 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
35,1411,1975
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
CHLOROCINNAMALDEHYDE (ALPHA-)
RTECS NUMBER
: GD6489990
CHEMICAL NAME
: Cinnamaldehyde, alpha-chloroCAS REGISTRY NUMBER
: 18365-42-9
BEILSTEIN REFERENCE NO. : 2205649
REFERENCE
: 2-07-00-00281 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H7-Cl-O
MOLECULAR WEIGHT
: 166.61
WISWESSER LINE NOTATION : VHYGU1R
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* alpha-Chlorocinnamaldehyde
* 2-Chloro-3-phenyl-2-propenal
* 2-Propenal, 2-chloro-3-phenyl*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 30 nmol
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
110,1,1983
CHLOROCINNAMIC ACID (4-)
RTECS NUMBER
: GD8490000
CHEMICAL NAME
: Cinnamic acid, p-chloroCAS REGISTRY NUMBER
: 1615-02-7
LAST UPDATED
: 199206
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C9-H7-Cl-O2
MOLECULAR WEIGHT
: 182.61
WISWESSER LINE NOTATION : QV1U1R DG
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* p-Chlorocinnamic acid
* 4-Chlorocinnamic acid
* 3-(p-Chlorophenyl)acrylic acid
* 3-(4-Chlorophenyl)-2-propenoic acid
* 2-Propenoic acid, 3-(4-chlorophenyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1622 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
23,714,1968
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >350 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
REFERENCE :
IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz
(East), Bombay 400 029, India)
Volume(issue)/page/year:
49,77,1987
V.40(2)-
1978-
CHLOROCYCLOHEXANE
RTECS NUMBER
: GU8685000
CHEMICAL NAME
: Cyclohexane, chloroCAS REGISTRY NUMBER
: 542-18-7
BEILSTEIN REFERENCE NO. : 1900796
REFERENCE
: 4-05-00-00048 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C6-H11-Cl
MOLECULAR WEIGHT
: 118.62
SYNONYMS/TRADE NAMES :
* Chlorocyclohexane
* Cyclohexyl chloride
* Monochlorocyclohexane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 gm/m3/2H
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 10(1),49,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 27(6),24,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - mouse
31 gm/m3/2H
(V/O
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,36,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4500 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 27(6),24,1962
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/m3/5H/26W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Blood - changes in leukocyte (WBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 10(1),49,1966
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 50 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5189
No. of Facilities: 26 (estimated)
No. of Industries: 2
No. of Occupations: 20
No. of Employees: 5771 (estimated)
No. of Female Employees: 729 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLORODICHLOROPHENOXY PHENOL (5:2:2,4-)
RTECS NUMBER
: KO1100000
CHEMICAL NAME
: Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl
CAS REGISTRY NUMBER
: 3380-34-5
BEILSTEIN REFERENCE NO. : 2057142
LAST UPDATED
: 199701
DATA ITEMS CITED
: 19
MOLECULAR FORMULA
: C12-H7-Cl3-O2
MOLECULAR WEIGHT
: 289.54
WISWESSER LINE NOTATION : QR CG FOR BG DG
COMPOUND DESCRIPTOR
: Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* CH 3565
* Irgasan
* Irgasan DP300
* Phenol, 5-chloro-2-(2,4-dichlorophenoxy)* Phenyl ether, 2'-hydroxy-2,4,4'-trichloro* 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
* Triclosan
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 750 ug/3D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10%
REACTION SEVERITY
: Mild
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,985,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth
&
Seventh Inter-American Conferences on Toxicology and Occupational
Medicine,
Miami, FL," Miami, FL, J.L. Halos, 1968-70 Volume(issue)/page/year:
6,245,1968/1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,985,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,985,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
38,64,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth
&
Seventh Inter-American Conferences on Toxicology and Occupational
Medicine,
Miami, FL," Miami, FL, J.L. Halos, 1968-70 Volume(issue)/page/year:
6,245,1968/1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 84 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,985,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,985,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 9300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
38,64,1969
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4400 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(105),28,1987
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mg/disc
REFERENCE :
JOSCDQ Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon
Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104,
Japan) V.101976- Volume(issue)/page/year: 15,243,1981
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1355
No. of Facilities: 1242 (estimated)
No. of Industries: 18
No. of Occupations: 55
No. of Employees: 73886 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1355
No. of Facilities: 4403 (estimated)
No. of Industries: 33
No. of Occupations: 52
No. of Employees: 188670 (estimated)
No. of Female Employees: 121892 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Mouse spot test; S cerevisiae gene
conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLORODIETHYLACETAMIDE (2:N,N-)
RTECS NUMBER
: AB5425000
CHEMICAL NAME
: Acetamide, 2-chloro-N,N-diethylCAS REGISTRY NUMBER
: 2315-36-8
BEILSTEIN REFERENCE NO. : 0605866
REFERENCE
: 4-04-00-00350 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C6-H12-Cl-N-O
MOLECULAR WEIGHT
: 149.64
WISWESSER LINE NOTATION : G1VN2&2
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* CDEA
* N-Chloroacetyldiethylamine
* Diethylamid kyseliny chloroctove
* N,N-Diethylchloroacetamide
* TL 83
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094) V.11962- Volume(issue)/page/year:
10,97,1965
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 315 mg/m3/4H
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(6),36,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 980 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 33(2),51,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 226 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(6),36,1991
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 270 mg/m3/2H
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(6),36,1991
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 175 mg/m3/4H
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(6),36,1991
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLORODINITROBENZENE (1,2-)
RTECS NUMBER
: CZ0525000
CHEMICAL NAME
: Benzene, 1-chloro-2,4-dinitroCAS REGISTRY NUMBER
: 97-00-7
LAST UPDATED
: 199710
DATA ITEMS CITED
: 19
MOLECULAR FORMULA
: C6-H3-Cl-N2-O4
MOLECULAR WEIGHT
: 202.56
WISWESSER LINE NOTATION : WNR BG ENW
COMPOUND DESCRIPTOR
: Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* CDNB
* 1-Chloor-2,4-dinitrobenzeen
* 1-Chlor-2,4-dinitrobenzene
* 1-Chloro-2,4-dinitrobenzene
* 4-Chloro-1,3-dinitrobenzene
*
*
*
*
*
*
*
*
6-Chloro-1,3-dinitrobenzene
1-Chloro-2,4-dinitrobenzol
1-Cloro-2,4-dinitrobenzene
1,3-Dinitro-4-chlorobenzene
2,4-Dinitrochlorobenzene
2,4-Dinitro-1-chlorobenzene
Dinitrochlorobenzol
DNCB
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 30 ug
REFERENCE :
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis.
(Munksgaard International Pub., c/o Publications Expediting Inc., 200
Meacham Ave., Elmont, NY 11003) V.11975- Volume(issue)/page/year:
2,247,1976
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ug/24H
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,600,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,600,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(2),48,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - peritonitis
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 17,217,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2340 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Liver - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(2),48,1988
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ug/m3/4H/17W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 29(8),59,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3 ug/plate
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.821960- Volume(issue)/page/year: 121,348,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
ADREDL Archives of Dermatological Research. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.2531975Volume(issue)/page/year: 266,315,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
131,215,1984
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
116,239,1983
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 10 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,307,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83616
No. of Facilities: 174 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1221 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83616
No. of Facilities: 82 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 170 (estimated)
No. of Female Employees: 14 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLORODINITROBENZOIC ACID (2:3,5-)
RTECS NUMBER
: DG4996500
CHEMICAL NAME
: Benzoic acid, 2-chloro-3,5-dinitroCAS REGISTRY NUMBER
: 2497-91-8
BEILSTEIN REFERENCE NO. : 2146480
REFERENCE
: 4-09-00-01359 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H3-Cl-N2-O6
MOLECULAR WEIGHT
: 246.57
WISWESSER LINE NOTATION : WNR BG CVQ ENW
SYNONYMS/TRADE NAMES :
* 2-Chloro-3,5-dinitrobenzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02903
CHLORODINITROBENZONITRILE (4:3,5-)
RTECS NUMBER
: DI2990000
CHEMICAL NAME
: Benzonitrile, 4-chloro-3,5-dinitroCAS REGISTRY NUMBER
: 1930-72-9
BEILSTEIN REFERENCE NO. : 1990451
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H2-Cl-N3-O4
MOLECULAR WEIGHT
: 227.57
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 4-Chloro-3,5-dinitrobenzonitrile
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 41,41,1986
CHLORODINITROPYRIDINE (2:3,5-)
RTECS NUMBER
: US6504750
CHEMICAL NAME
: Pyridine, 2-chloro-3,5-dinitroCAS REGISTRY NUMBER
: 2578-45-2
LAST UPDATED
: 199812
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C5-H2-Cl-N3-O4
MOLECULAR WEIGHT
: 203.55
SYNONYMS/TRADE NAMES :
* 2-Chloro-3,5-dinitropyridine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546346
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546346
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546346
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546346
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546346
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
CHLOROETHANOL (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KK0875000
Ethanol, 2-chloro107-07-3
0878139
4-01-00-01372 (Beilstein Handbook Reference)
199907
88
C2-H5-Cl-O
80.52
Q2G
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aethylenechlorhydrin
* 2-Chloorethanol
* 2-Chloraethanol
* 2-Chlorethanol
* delta-Chloroethanol
* 2-Chloroethanol
* beta-Chloroethyl alcohol
* 2-Chloroethyl alcohol
* Chloroethylowy alkohol
* 2-Cloroetanolo
* Ethyleen-chloorhydrine
* Ethylene chlorhydrin
* Ethylene chlorohydrin
* Ethylene glycol, chlorohydrin
* Glicol monocloridrina
* Glycol chlorohydrin
* Glycolmonochloorhydrine
* Glycomonochlorhydrin
* Glycol monochlorohydrin
* Monochlorhydrine du glycol
* 2-Monochloroethanol
* NCI-C50135
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/2H
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
16,382,1970
TYPE OF TEST
ROUTE OF EXPOSURE
: Standard Draize test
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 33 mg
REACTION SEVERITY
: Moderate
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
16,382,1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 9 mg/6H
REACTION SEVERITY
: Moderate
REFERENCE :
BUYRAI Bulletin of Parenteral Drug Association. (Philadelphia, PA)
V.1-31,
1946-77. Volume(issue)/page/year: 31,25,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 305 ppm/2H
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,277,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
36(4-6),376,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
: Rodent - rat
DOSE/DURATION
: 290 mg/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
36(4-6),376,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 293 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-275,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 84 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
36(4-6),376,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(8),13,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 60,568,1971
TYPE OF TEST
ROUTE OF EXPOSURE
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
(V/O
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 385 mg/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
36(4-6),376,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,66,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 97 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,19,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),54,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 91 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(8),13,1978
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,19,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,19,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),54,1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
1,207,1944
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - general
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
110 mg/kg
anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 870 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),54,1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 27,93,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,19,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 15(2),54,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Subcutaneous
: Amphibian - frog
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
1,207,1944
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5670 mg/kg/12W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in pituitary weight
Related to Chronic Data - death
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,313,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3400 mg/m3/15M/11D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Blood - hemorrhage
Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
1,207,1944
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),37,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
91 mg/kg/26W-I
Gastrointestinal - changes in structure or function of endocrine pancreas
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(7),102,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6188 mg/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-275,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-275,1985
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 384 mg/kg/30D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 60,1163,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1152 mg/kg/12W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 60,1163,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Unreported
: Rodent - rat
DOSE/DURATION
: 910 mg/kg/26W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(8),13,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1411 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-275,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1154 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-275,1985
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1932 mg/kg/15W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,313,1975
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1100 mg/kg
SEX/DURATION
: female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides,
Food
Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.B111976- Volume(issue)/page/year:
17,381,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 20 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
26,367,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3333 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 2914 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19,98,1992
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
26,367,1974
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation in microorganisms
: Bacteria - Klebsiella pneumoniae
: 15 mmol/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 25,85,1969
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 40 gm/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
30,9,1980
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 74500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
138,33,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 20 mg/L
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 1(3),37,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 12 gm/L
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 1(3),37,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 mg/m3
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(11),9,1971
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 mg/m3
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(11),9,1971
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 ug/kg
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(8),13,1978
TYPE OF TEST
TEST SYSTEM
: Mutation in microorganisms
: Rodent - mouse Lymphocyte
(V/O
(V/O
DOSE/DURATION
: 80 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,85,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 980 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
14,165,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1200 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-CL 3.3 mg/m3 (1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 5 ppm (16 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,108,1971
OSHA PEL (Gen Indu):8H TWA 5 ppm (16 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 ppm (16 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5 ppm (16 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5 ppm (16 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (3 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 1 ppm (3 mg/m3), Skin, JAN1999
OEL-AUSTRIA:TWA 1 ppm (3 mg/m3);Skin JAN 1993
OEL-BELGIUM:STEL 1 ppm (3.3 mg/m3);Skin JAN 1993
OEL-FINLAND:STEL 1 ppm (3 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 1 ppm (3 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (3 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 5 ppm (16 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 1 mg/m3, MAC(STEL) 3 mg/m3, JAN1999
OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993
OEL-SWEDEN:STEL 1 ppm (3.5 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (3 mg/m3);STEL 5 ppm (15 mg/m3);Skin JAN 1993
OEL-TURKEY:TWA 5 ppm (16 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (3 mg/m3);STEL 1 ppm (3 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHYLENE CHLOROHYDRIN-air:CL 1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4018
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 476 (estimated)
No. of Female Employees: 68 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae
gene conversion
EPA GENETOX PROGRAM 1988, Negative: S pombe-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ethylene chlorohydrin, 2513
NTP Carcinogenesis Studies (dermal);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-275,1985
CHLOROETHOXYETHANOL (2,2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
(Research
KK1350000
Ethanol, 2-(2-chloroethoxy)628-89-7
0506015
3-01-00-02078 (Beilstein Handbook Reference)
199701
5
C4-H9-Cl-O2
124.58
QZO2G
Primary Irritant
* 2-(2-Chloroethoxy)ethanol
* 2-(2'-Chloroethoxy)ethanol
* Diglycol chlorhydrin
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLOROETHYL CHLOROFORMATE (2-)
RTECS NUMBER
: LQ5950000
CHEMICAL NAME
: Formic acid, chloro-, 2-chloroethyl ester
CAS REGISTRY NUMBER
: 627-11-2
BEILSTEIN REFERENCE NO. : 0506639
REFERENCE
: 4-03-00-00024 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C3-H4-Cl2-O2
MOLECULAR WEIGHT
: 142.97
WISWESSER LINE NOTATION : GVO2G
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 2-Chloroethyl chloroformate
* 2-Chlorethylester kyseliny chlormravenci
* Chloroformic acid 2-chloroethyl ester
* TL 207
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year:
NDCrc-132,JUN1942
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
CHLOROETHYL ETHER (BIS,2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
KN0875000
Ether, bis(2-chloroethyl)
111-44-4
0605317
4-01-00-01375 (Beilstein Handbook Reference)
199907
58
C4-H8-Cl2-O
143.02
G2O2G
Agricultural Chemical
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(beta-chloroethyl) ether
* Bis(2-chloroethyl) ether
* Chlorex
* 1-Chloro-2-(beta-chloroethoxy)ethane
* Chloroethyl ether
* Clorex
* DCEE
* 2,2'-Dichloorethylether
* 2,2'-Dichlor-diaethylaether
* 2,2'-Dichlorethyl ether
* beta,beta-Dichlorodiethyl ether
* Dichloroether
* Dichloroethyl ether
* Di(beta-chloroethyl)ether
* Di(2-chloroethyl) ether
* beta,beta'-Dichloroethyl ether
* sym-Dichloroethyl ether
* 2,2'-Dichloroethyl ether
* Dichloroethyl ether
* Dichloroethyl oxide
* 2,2'-Dicloroetiletere
* Dwuchlorodwuetylowy eter
* ENT 4,504
* Ethane, 1,1'-oxybis(2-chloro* Ether dichlore
* 1,1'-Oxybis(2-chloro)ethane
* Oxyde de chlorethyle
* RCRA waste number U025
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation tes