CV
Annalisa Masi
P
E R S O N A L
I
N F O R M A T I O N
NAME: ANNALISA MASI
PLACE OF BIRTH: Rome
DATE OF BIRTH: 17.12.1972
CIVIL STATUS: married
NATIONALITY: italian
HOME ADDRESS: Via Rosario Livatino, 00065 - Fiano Romano (RM)
TELEPHONES: +39-0765-389109 +39-349-4480721
E-MAIL: annalisa.masi@gmail.com
E D U C A T I O N A N D T R A I N I N G
2006
Ph.D. in Pharmaceutical Sciences, Pharmacy department of "La Sapienza" University of
Rome.
Doctoral thesis: “Design and Synthesis of bioactive peptide: Analogs of the chemotactic agent
for-Met-Leu-Phe-OMe” developed at CNR Biomolecular Chemistry Institute
laboratories, Pharmacy department of "La Sapienza" University of Rome . Tutor:
Prof. Mario Paglialunga Paradisi.
2001
Achieved license to practise chemistry.
2000
Chemistry degree within Organic course at "La Sapienza" University of Rome.
Final score: 102/110.
Experimental thesis on "Study for the diastereoselective synthesis of the 13-Stemarene"
developed at the Chemistry department of "La Sapienza" University of Rome. Supervisor:
Prof. Rinaldo Marini Bettolo, Co-supervisor: Prof. Mario Brufani.
1991
Land surveyor certificate at Agricultural Technical School “De Cillis” of Rome. Score: 60/60.
W OR K
E X P E RI E N CE
E S P E R I E N Z E P R O F E S S I O N A L I
Nov 2011-Present Research ISOF-CNR Bologna
2009 – 2010
Research activity collaboration grant, conferred by Monterotondo (Rome) Section of CNR
Crystallographic Institute to perform research activity under the direction of Dr. Luciano Cellai
on "Study on the delivery of new therapeutic nucleic acids ".
2008 –2009
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Research activity collaboration grant, conferred by Monterotondo (Rome) Section of CNR
Crystallographic Institute to perform research activity under the direction of Dr. Luciano Cellai,
in the research program " Studies on the mechanism of action of Ribavirin ".
2007 – 2008
Research activity collaboration grant, conferred by Monterotondo (Rome) Section of CNR
Crystallographic Institute to perform research activity under the direction of Dr. Luciano Cellai,
in the research program "Synthesis of new Rifamycins derivatives".
2003 – 2006
Ph.D. in bioactive peptides design and synthesis: α-Peptide/β-Sulfonamidopeptide hybrids:
analogs of the chemotactic agent for-Met-Leu-Phe-OMe. Experimental work carried out at
CNR Biomolecular Chemistry Institute laboratories, Pharmaceutical Studies Department of
“La Sapienza” University of Rome, under the supervision of Prof. Mario Paglialunga Paradisi
and Dr. Cesare Giordano.
2005 – 2006
Research activity at the Biochemist Sciences Department "A. Rossi Fanelli" and
Pharmaceutical Studies Department of "La Sapienza" University to perform research
activity under the direction of Prof. Valerio Consalvi, in the research program "Spectroscopic
and Thermodynamic studies of single chain antibodies (scFv)" ambit.
2004 – 2005
Professional cooperation at the Pharmaceutical Studies Department of "La Sapienza"
University to perform research activity under the direction of Dr. Cesare Giordano, in the
research program " Synthesis of amide substrates of arylpropionic acids for stereospecific
enzymatic hydrolysis ".
2003 – 2004
Research activity collaboration grant, conferred by Monterotondo (Rome) Section of CNR
Crystallographic Institute to perform researches under the direction of Dr. Luciano Cellai, in
the research program "Studies on the mechanism of action of Ribavirin".
2000 – 2002
Consultant at Biosint S.p.A. in Sermoneta (LT), a Sigma Tau group company, assigned to the
R&D Laboratory, synthesis sector. Such role provides for the autonomous execution of
projects agreed with the manager, researches execution, reports editing on obtained results,
use of routine instrumentations and frequent contacts with research consultants or analytic
and production sector personnel.
2000
Co-operation with Prof. R. Marini Bettolo at Natural Substances Center (C.N.R., Rome) in
studies on cycloaddiction stereochemistry (Diels-Alder).
P U B L I C A T I O N S
1. “ -Peptide/-sulfonamidopeptide hybrids: Analogs of the chemotactic agent for-MetLeu-Phe-OMe”. C. Giordano, G. Lucente, A. Masi, M. Paglialunga Paradisi, A. Sansone,
S.Spisani; Bioorganic & Medicinal Chemistry, 14, 2642-2652, (2006) ;
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2. “Synthesis, conformation and biological acticity of centrally modified pseudopeptidic
analogues of for-Met-Leu-Phe-OMe”. C. Giordano, G. Lucente, A. Masi, M. Paglialunga
Paradisi, A. Sansone, S. Spisani. Amino Acids 33 (3), 477, (2007);
3. “Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 amyloid sequence”. C. Giordano, A. Masi, A. Pizzini, A. Sansone, V. Consalvi, R. Chiaraluce
and G. Lucente. European Journal of Medicinal Chemistry 44, 179-189 (2009);
4. “Indium-doped gallophosphate NH4[NiGa1.84In0.16(PO4)3(H2O)2]: synthesis, X-ray crystal
structure and IR spectroscopy”. F. Capitelli, A. Masi, Brahim El Bali, R. Esserli. Z. Kristallogr.
225 (2010) 359-365;
5. "Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline
surrogates in position 2" C. Giordano, A. Sansone, A. Masi, G. Lucente, P. Punzi, A. Mollica,
F. Pinnen, F. Feliciani, I. Cacciatore, P. Davis, J. Lai, S.W. Ma, F. Porreca, V. Hruby.
European Journal of Medicinal Chemistry 45, 4594-4600 (2010);
6. “Affinity of the anthracycline antitumoral drugs Doxorubicin and Sabarubicin for human
telomeric G-quadruplex structures”. I. Manet, F. Manoli, B. Zambelli, G. Andreano, A. Masi, L.
Cellai and S. Monti. Physical Chemistry Chemical Physics 13, 540 – 551 (2011);
7. “A cationic ZnII porphyrazine induces a stable parallel G-quadruplex
conformation in human telomeric DNA” Manet I, Manoli F, Donzello MP, Viola E,
Andreano G, Annalisa Masi, Cellai L, Monti S Org Biomol Chem 9, 684 – 688
(2011);
8. “Complexes of the antitumoral drugs Doxorubicin and Sabarubicin with telomeric Gquadruplex in basket conformation: ground andexcited state properties”. Ilse Manet, Francesco
Manoli, Barbara Zambelli, Giuseppina Andreano, Annalisa Masi, Luciano Cellai, Stefano
Ottani, Giancarlo Marconi and Sandra Monti. Photochem.Photobiol. Sci. 10, 1236-37 (2011);
9. “Tetra-2,3-pyrazinoporphyrazines with Externally Appended Pyridine Rings. 10. A
Water Soluble Bimetallic (ZnII/PtII) Porphyrazine Hexacation as Potential Plurimodal Agent
for Cancer Therapy: Exploring the Behaviour as Ligand of Telomeric DNA G Quadruplex
Structures” Ilse Manet, Francesco Manoli, Maria Pia Donzello, Claudio Ercolani, Daniela
Vittori, Luciano Cellai, Annalisa Masi, and Sandra Monti. Inorganic Chemistry 50, 7403-11
(2011);
10. “Inhibition of amyloid peptide fragment Aß25-35 fibrillogenesis and toxicity by Nterminal β-amino acid-containing esapeptides: is taurine moiety essential for in vivo
effects?“ Cesare Giordano, Anna Sansone, Annalisa Masi, Alessandra Masci, Luciana
Mosca, Roberta Chiaraluce, Alessandra Pasquo and Valerio Consalvi. Chemical Biology &
Drug Design 79, 30-37 (2012).
R
E P O R T S
1. "La Sapienza” University of Rome, Conference on the Scientific Research, Pharmacy
Faculty, -Peptido Sulfonamides. Analogues of bioactive peptides containing taurine and
chiral -amino-ethanesulfonic acid residues (2004).
2.
-Peptido Sulfonamides. Analogues of bioactive peptides containing taurine and chiral
-amino-ethanesulfonic acid residues , Annalisa Masi. European School of Medicinal
Chemistry-Urbino (XXVI Advanced Course of Medicinal Chemistry and “E. Duranti”
National Seminar for PhD Students), Urbino, 2-7 Luglio 2006, pag. 71.
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3.
(5’R)- and (5’S)-5’,8-Cyclo-2’-deoxyguanosine Lesions: Synthetic Strategies and
Biomimetic Studies, Michael. A. Terzidis, Annalisa Masi, Giuseppina Andreano, Luciano Cellai,
Jean-Luc Ravanat, and Chrysosstomos Chatgilialoglu.COST CM0603 Chembioradical
Zagreb, June 14th - 17th, 2011, pag. 37
S K I L L S A N D C O M P E T E N C E S

Study of the structure -function relationships in proteins and nucleic
acids, in their complexes between them and with small molecules ,
methodological developments for facilitating structural studies on bio macromolecules, by the synthesis of modified models. Study of action
mechanism of the
antiviral drugs, Ribavirin. Synthesis of new Rifamycins
derivatives, used in the treatment of ch olestasis. Study on the molecular basis of
DNA damage by radical species and of the interaction of anticancer
compounds with telomeric DNA, as a contribution to their anticancer activity.
Development of bifunctional RNA aptamers able to cross the blood -brain
barrier as novel therapeutic tools for amyotrophic lateral sclerosis (ALS) .

Use of synthesis procedures and organic compounds separation in accordance with
standards required in chemical laboratories. Use of spectroscopic techniques for synthesis
products identification: ultraviolet and infrared spectroscopy, mass and nuclear magnetic
resonance spectroscopy.

Solid state automatic synthesis, purification and characterization of oligonucleotides;
use
of
chemical
and
biochemical
techniques
as:
HPLC cromatography (RP and SAX); TLC; column cromatography; gel electrophoresis
(PAGE); enzymatic digestion.

Research projects planning and management; bibliographic researches execution;
experimental results and analytic data organization; reports editing and electronic format
presentation.

Use of analytic equipment: HPLC HP 1100 Series LC/MSD System with management
software HP ChemStation; spectrometer NMR Bruker 400 MHz with management software
Xwin-nmr; Nucleic Acid Synthesis System EXPEDITE 8900
F
O R E I G N
L A N G U A G E S
Fair experience in written and spoken english language; fair knowledge of scientific english
language.
I T
S
K I L L S
Good experience in main software packages for MS Windows (MS Office suite) and in
bibliographic research software (SciFinder).
I hereby authorize the use of my personal details solely for circulation within the company.
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