MEDICAL GRAND ROUNDS 2013-2014 Medical Grand Rounds take place on Mondays at 12:30 PM in the Block Amphitheatre at the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal: September 16 25th ANNUAL BERTHA & NACHUM MIZNE MEMORIAL LECTURE “A DAUNTING CHALLENGE.....WHEN LESS IS MORE” THE HARSH CLINICAL REALITY OF EATING DISORDERS Patricia McMillan, MD Assistant Professor of Anesthesia McGill University Attending Staff, Departments of Adult Critical Care and Anesthesia Jewish General Hospital Educational Objectives: 1. To heighten sensitivity and awareness to eating disorders and their potential progression to severe malnutrition 2. To describe medical presentations and complications of eating disorders 3. To recognize severe malnutrition as a medical emergency. To understand starvation physiology and the refeeding syndrome 4. To highlight the mandatory need for a coordinated multidisciplinary approach to such patients including triage; levels of care and a continuum of care September 23 MCGILL UNIVERSITY GLOBAL HEALTH INITIATIVE: EXPERIENCES AND FUTURE PROJECTS IN HAITI Yen-I Chen MD PGY-4 Gastroenterology, McGill University Kevin Chan MD PGY-4 Medical Oncology, McGill University Supervisors: Michelle Elizov MD, MHPE Assistant Professor of Medicine, McGill University Division of Internal Medicine, Jewish General Hospital Jeffrey Wiseman MD, MA (Ed) Assistant Professor of Medicine, McGill University Division of Internal Medicine, McGill University Health Center Educational Objectives: 1. Describe the current health care status in Haiti 2. Overview of McGill's initiative in creating a rural rotation in internal medicine in Haiti 3. Describe current projects in capacity building focusing on education September 30 MYCOSIS FUNGOIDES AND SEZARY SYNDROME: WHAT EVERY INTERNIST SHOULD KNOW ABOUT DIAGNOSIS AND THERAPY Alain H. Rook, MD Professor of Dermatology Director, Cutaneous Lymphoma Program Perelman School of Medicine University of Pennsylvania Philadelphia, PA Educational Objectives: 1. Learn how to recognize clinically cutaneous T-cell lymphoma 2. Learn how to diagnose cutaneous T-cell lymphoma 3. Learn how to treat cutaneous T-cell lymphoma October 7 IMPLEMENTING PERSONALIZED MEDICINE AT THE JGH-SEGAL: THE NEW MOLECULAR PATHOLOGY CENTER Alan Spatz, MD Professor of Pathology and Oncology, McGill University Director, Department of Pathology, Jewish General Hospital Canada Research Chair in Molecular Pathology Educational Objectives: At the end of the presentation the participants will understand: 1. What is the role of Molecular pathology in Personalized Medicine 2. What are the structure, organization and activities of the JGH Molecular Pathology Center 3. What will be the patient trajectory until the point of therapeutic decision October 14 No Rounds - Thanksgiving October 21 THE NOT-SO-USELESS LEFT ATRIAL APPENDAGE- POSSIBLE ROLE IN MYOCARDIAL REGENERATION Ronen Beeri, MD, FACC Associate Professor of Medicine (Cardiology), Hebrew University School of Medicine Director, Cardiovascular Research Center Heart Institute, Hadassah- Hebrew University Medical Center Jerusalem, Israel Educational Objectives: 1. Breaking the paradigm that myocardial remodeling involves purely hypertrophic response 2. Understand the untapped potential of the atrial appendages as progenitor cell reservoirs 3. Present the potential of the left atrial appendage to create a "complete regeneration package” October 28 ASSOCIATION BETWEEN GAIT DISORDERS, COGNITIVE DECLINE AND VITAMIN D DEFICIENCY: WHAT HAVE WE LEARNED? WHAT ARE THE MAIN IMPLICATIONS FOR OUR CLINICAL PRACTICE? Pr. Olivier Beauchet, MD, PhD Department of Neuroscience Geriatrics Division and Memory Clinic Angers University Hospital and School of Medicine, France Educational Objectives: 1. To examine the interactions between gait disorders, cognitive decline and vitamin D deficiency 2. To explain the mechanism of higher-levels gait control disorders related to cognitive decline and vitamin D deficiency 3. To underscore the main clinical implications for diagnosis and treatment of higher-levels gait control disorders November 4 CANADIAN PATIENT SAFETY WEEK THE ROLE OF PHYSICIANS IN PREVENTING HEALTHCARE-ASSOCIATED INFECTIONS Yves Longtin, MD Associate Professor of Medicine, McGill University Division of Infectious Diseases, Jewish General Hospital Educational Objectives: 1. Review the institutional burden of healthcare-associated infections 2. Described various strategies to prevent healthcare-associated infections 3. Review the current literature on the efficacy of Chlorhexidine gluconate to prevent healthcare-associated infections November 11 SLEEP-DISORDERED BREATHING AND CARDIOMETABOLIC INTERACTIONS: CURRENT EVIDENCE R. John Kimoff, MD, FRCPC Associate Professor of Medicine, McGill University Director, Sleep Laboratory Respiratory Division McGill University Health Centre (Royal Victoria Hospital) Educational Objectives: 1. Discuss recent evidence on the prevalence and management of sleep-disordered breathing 2. Describe mechanisms underlying cardiometabolic consequences of sleep-disordered breathing 3. Summarize current data linking sleep-disordered breathing to cardiometabolic complications in the general adult population, during pregnancy and in chronic congestive heart failure November 18 BIOLOGICS AND DERMATOLOGY IN 2013 Marc Bourcier, MD, FRCPC Assistant Professor in Clinical Teaching Division of Dermatology, Faculty of Medicine and Health Sciences Sherbrooke University Educational Objectives: 1. To better understand the systemic implications of moderate to severe psoriasis. 2. Review the current use of biological agents for psoriasis, and other dermatological conditions 3. An overview of the future in the management of moderate to severe psoriasis November 25 A LOCAL REGISTRY FOR HEREDITARY GI CANCER SYNDROMES Polymnia Galiatsatos, MD Assistant Professor of Medicine, McGill University Division of Gastroenterology, Department of Medicine Jewish General Hospital Educational Objectives: 1. To recognize the features of the major hereditary GI cancer syndromes 2. To understand the screening / follow-up required for the various conditions 3. To become familiar with a new local registry that is being developed, and how it could impact patient care and research December 2 DRUGS FOR TYPE 2 DIABETES - ASSESSING CARDIOVASCULAR SAFETY Agnieszka Majdan, MD Assistant Professor of Medicine, McGill University Division of Endocrinology, McGill University Educational Objectives: 1. Appreciate the importance of CV risk reduction in diabetes 2. Review the available data on CV safety of diabetes drugs December 9 PATIENT SAFETY: LATEST BUZZWORD OR GENUINE RESEARCH DOMAIN? Blair Schwartz, MDCM, MHS, FRCPC Assistant Professor of Medicine, McGill University Division of General Internal Medicine, Department of Adult Critical Care, Jewish General Hospital Educational Objectives: 1. To define patient safety as it applies to the care of the hospitalized patient 2. To review methodological challenges in the current patient safety literature 3. To explore past and current patient safety research at McGill University December 16 HIGHLIGHTS OF SEGAL CANCER CENTER RESEARCH PRESENTED AT THE 2013 EUROPEAN CANCER CONGRESS ANNUAL MEETING Tamim Niazi, MD Assistant Professor, Department of Oncology, McGill University Staff, Division of Radiation Oncology, Segal Cancer Center, Jewish General Hospital Te Vuong, MD Associate Professor, Department of Oncology McGill University Staff, Division of Radiation Oncology, Segal Cancer Center, Jewish General Hospital &Young Soo Rho, MD Research Associate, Department of Oncology and Medicine, Segal Cancer Center, Jewish General Hospital Educational Objectives: 1. Review facts/history on treatments of Colon, rectal and prostate Cancer 2. Understand the rationale, background, results of the studies presented at the European Cancer Congress 2013 (ECCO-ESMO-ESTRO) Annual meeting 3. Discuss its implication into clinical practice January 6 THE SHAKING PALSY: 200 YEARS OF PARKINSON'S' DISEASE Michael Sidel, MD, CM, FRCP(C) Assistant Professor, Neurology and Neurosurgery, McGill University Department of Neurosciences, Jewish General Hospital Educational Objectives: 1. To review the clinical and pathological features of Parkinson's disease 2. Update on current treatments and treatment algorithms 3. Review new and emerging treatment modalities for Parkinson's disease January 13 VITAMINS: WHO NEEDS THEM? CURRENT KNOWLEDGE AND RECENT JGH RESEARCH L. John Hoffer, MD PhD Professor of Medicine, McGill University Divisions of Internal Medicine and Endocrinology and Metabolism, Jewish General Hospital Educational Objectives: 1. To update knowledge regarding vitamin and mineral nutrition in adults 2. To provide rational guidelines for appropriate use of vitamin supplements Contact Person: Rubin Becker, MD, Chief, Division of Internal Medicine, Tel. 514-340-7596. January 20 CARBAMEPENASE PRODUCING K. pneumoniae (KPC) GOES GLOBAL: EPIDEMIOLOGY, MANAGEMENT AND PREVENTION Deborah Ben-David, MD Jewish General Hospital - Visiting Scientist in Infection Prevention and Control Medical Director, Infection Control Service and Infectious Diseases Consultant, Sheba Medical Center Hospital Epidemiologist, National Center for Infection Control, Tel Aviv, Israel Educational Objectives: 1. To review recent findings in the epidemiology of this organism 2. Update in the management of infections with this organism 3. Discuss infection control interventions in endemic and epidemic settings January 27 CONTRAST ULTRASOUND: DIAGNOSTIC AND THERAPEUTIC APPLICATIONS FOR 2014 AND BEYOND Howard Leong-Poi, MD Associate Professor of Medicine, University of Toronto Chief, Division of Cardiology Scientist, Kenan Research Centre in the Li Ka Shing Knowledge Institute St. Michael’s Hospital Educational Objectives: 1. To review the present applications for contrast ultrasound in medical practice 2. To discuss contrast ultrasound for perfusion and molecular imaging 3. To review potential therapeutic applications for ultrasound and carrier microbubbles February 3 EIGHTEENTH ANNUAL HUMANIZATION OF CARE AWARENESS PROGRAM WAITER THERE'S A FLY IN MY SOUP....UNDERSTANDING AND LEARNING FROM COMPLAINTS Rosemary Steinberg, BA, BSW, MSW Local service quality and complaints commissioner Jewish General Hospital & Paul Warshawsky, MD Assistant Professor of Medicine, McGill University Chief, Department of Adult Critical Care Division of Pulmonary, Department of Medicine Jewish General Hospital Educational Objective: Understanding the complaint process and learning to prevent complaints February 10 THE HEMOPHAGOCYTIC SYNDROME: A SINISTER EMERGENCY Paraish Misra, MD, CM Internal Medicine Second Year Resident McGill University & Jewish General Hospital Educational Objectives: 1. To appreciate the aggressiveness of Hemophagocytic Lymphohistiocytosis through case review 2. To understand the systemic manifestations and key diagnostic features 3. To review current treatment options & II. A CURIOUS CASE OF ARDS Abdulrahman Al-Fares, MD, MRCP (UK) Internal Medicine Second Year Resident McGill University & Jewish General Hospital Educational Objectives: 1. To explore an atypical cause of ARDS 2. To establish the natural history, pathophysiology and clinical manifestation of such a cause 3. To explore management strategies that could be implemented February 17 57 YEAR OLD WOMAN ADMITTED WITH PYODERMA GANGRENOSUM Luc Trudeau, MD Assistant Professor of Medicine, McGill University Division of Internal Medicine, Jewish General Hospital Educational Objectives: 1. To recognize systemic diseases associated with pyoderma gangrenosum 2. To know potential complications associated with the treatment of rheumatoid arthritis 3. To review causes of bilateral lung infiltrates February 24 BETA BLOCKERS AND ANGIOTENSIN RECEPTOR BLOCKERS IN BICUSPID AORTIC VALVE DISEASE AORTOPATHY Judith Therrien, MD Associate Professor of Medicine, McGill University Division of Cardiology, Jewish General Hospital Educational Objectives: 1. To understand that BAV is associated with ascending aortopathy 2. To understand the pathogenesis of ascending aortopathy 3. To understand how BB or ARB may work to delay aortopathy progression March 3 ADVANCES IN THE TREATMENT OF GOUT Sabrina Fallavollita, MD Assistant Professor of Medicine, McGill University Division of Rheumatology, Jewish General Hospital Educational Objectives: 1. To review the pathogenesis in gout 2. To discuss new and emerging treatments in gout March 10 CURRENT MANAGEMENT OF LIPID DISORDERS Morris Schweitzer PhD, M.D., FRCP(C) Associate Professor, Faculty of Medicine McGill University, Montreal, Quebec Canada Director, Lipid Research and Management Clinic Co-Director, Centre for Vascular Prevention Staff, Division of Endocrinology Jewish General Hospital Educational Objectives: 1. To understand how cholesterol metabolism influences the formation of atherosclerotic disease 2. To understand the mechanism of action of lipid lowering drugs and how cholesterol reduction reduces cardiovascular disease March 17 DICER1 AND CANCER: MUTATIONS, miRNAS AND MECHANISMS William D. Foulkes, MD, PhD James McGill Professor, Departments of Medicine, Human Genetics & Oncology McGill Program in Cancer Genetics, McGill University Department of Medical Genetics, Jewish General Hospital Educational Objectives: 1. To gain appreciation of the diverse presentations associated with germ-line DICER1 mutations 2. To compare and contrast DICER1 with traditional tumor suppressor genes and oncogenes 3. To be aware of the complex world of miRNAs and their regulation March 24 THE NEW ANTICOAGULANTS - QUESTIONS - AND SOME ANSWERS Sam Schulman, MD, PhD Professor of Medicine, McMaster University Thrombosis Service, McMaster Clinic, Hamilton Health Sciences - General Hospital Educational Objectives: 1. To discuss selection of patients for the new oral anticoagulants 2. To review perioperative management related to new oral anticoagulants 3. To discuss approaches to bleeding management in patients on new oral anticoagulants 4. To highlight issues related to adherence to new oral anticoagulants March 31 EVIDENCE BASED MEDICINE Chantal Cassis, MD Assistant Professor of Medicine, Division of Hematology & Department of Oncology, McGill University Division of Hematology, Jewish General Hospital Educational Objectives: 1. Awareness of the GRADE working group system to rate quality of evidence 2. Understanding of the limitations of evidence 3. Appreciation of shared decision making April 7 ONCOLOGY AND AGING PROGRAM AT MCGILL: CLINICAL, RESEARCH AND TEACHING PERSPECTIVES Doreen Wan-Chow-Wah, MD, FRCPC Assistant Professor of Medicine, McGill University Staff, Division of Geriatric Medicine, McGill University Health Centre and Jewish General Hospital Medical Director, Geriatric Oncology Clinic, Segal Cancer Centre & Associate Member, Department of Oncology, McGill University Educational Objectives: 1. Learn about the Geriatric Oncology clinic of the Segal Cancer Centre, JGH 2. Understand the various research projects conducted by our group on cancer in older adults 3. Learn about the teaching activities and opportunities in Geriatric Oncology at McGill April 14 NO ROUNDS - 1ST DAY PASSOVER ON APRIL 15 April 21 NO ROUNDS - EASTER MONDAY April 28 COPD AND PULMONARY REHABILITATION: MORE THAN A TRAINING PROGRAM Nathalie Saad, MD, MBA Assistant Professor of Medicine, McGill University Division of Pulmonary Medicine, Jewish General Hospital Educational Objectives: 1. To explain the role of pulmonary rehabilitation in the management of COPD patients 2. To understand which and how patients benefit from pulmonary rehabilitation (the evidence behind pulmonary rehabilitation). 3. To explain patients' transition from acute care to pulmonary rehabilitation May 5 I. VITAMIN B12 DEFICIENCY IN INFLAMMATORY BOWEL DISEASE: THE PREVALENCE, RISK FACTORS, EVALUATION AND MANAGEMENT Robert Battat, MD Second Year Internal Medicine Resident, McGill University & Jewish General Hospital Educational Objectives: 1. Understanding the prevalence of and the risk factors for Vitamin B12 Deficiency in Inflammatory Bowel Disease (IBD) 2. Diagnostic and therapeutic approach for Vitamin B12 Deficiency in IBD (including screening, approach to low serum B12 in IBD, treatment and prophylactic regimens in IBD Patients) 3. Overview of current reviews and studies analyzing this topic II. SAFETY OF DIGESTIVE ENDOSCOPY IN THE SETTING OF RECENT ACUTE CORONARY SYNDROME Alastair Dorreen, MD Second Year Internal Medicine Resident, McGill University & Jewish General Hospital Educational Objectives: 1. Understand the indications for and complications of endoscopy following ACS 2. Appreciate the role for gastroprotective agents following ACS May 12 CLINICAL ETHICS ROUNDS "BUT THEY SAID THEY WANT US TO DO EVERYTHING!": IS THERE STILL ROOM FOR CLINICAL JUDGEMENT IN LEVEL OF INTERVENTION CONVERSATIONS? Lucie Wade, MSc (Bioethics) Clinical Ethicist Ethics Program Office Jewish General Hospital Educational Objectives: 1. To use clinical ethics case review to identify and discuss the ethical challenges many clinicians experience when trying to appropriately apply the Level of Intervention (LOI) policy 2. To review ethical principles, norms, and standards central to goals of care conversations 3. To clarify the role and limits of both clinical judgment and patient preferences in LOI conversations May 26 BIOCHEMISTRY DETECTIVES: WHAT GOES ON BEHIND THE LABORATORY DOORS? Elizabeth MacNamara, MD Associate Professor of Medicine McGill University Chief, Division of Medical Biochemistry & Department of Diagnostic Medicine Jewish General Hospital Educational Objectives: 1. To learn what happens when you let us know you think there is a problem in our laboratory 2. Using real examples of your complaints to show how we use different methods to discover what happened and learn interesting facts 3. To understand the limitations of using near patient testing and errors that occur 4. To understand the differences between laboratories and why you should be wary of using numbers and cut off values from the literature June 2 LIVALYSIS: FROM FAILURE TO SUCCESS TO FAILURE Gershon Frisch, MD Assistant Professor of Medicine, McGill University Division of Nephrology, Jewish General Hospital Educational Objectives: 1. To review the historical evolution of the miraculous therapy called Dialysis 2. To understand the pitfalls of Dialysis 3. To highlight the need for drastic improvements in transplantation rates June 9 VIRAL HEPATITIS IN IMMIGRANTS: RECOGNIZING AND DECREASING THE BURDEN Christina Greenaway, MD Associate Professor of Medicine, McGill University Division of Infectious Diseases, Jewish GeneralHospital Educational Objectives: 1. Review recent epidemiology of viral hepatitis in immigrants 2. Provide a brief update on new screening recommendations for viral hepatitis 3. Discuss rational screening and vaccination strategies for viral hepatitis in immigrants June 16 APPROACH TO DRUG HYPERSENSITIVITY Fanny Silviu-Dan, MD Assistant Professor of Medicine, McGillUniversity Division of Allergy and Immunology, Jewish General Hospital Educational Objectives: 1. Classification of reactions 2. Diagnosis approach 3. Management - Multiple Case studies will be employed .