Clinical pharmacology and pharmacotherapy
4th year, winter term 2009/10
Time schedule:
Lecture – every Wednesday 8.25 – 10.10 hrs, Kalinčiakova, 4th floor, No 407
Seminar - every Thursday 13.00 – 14.45 hrs, Kalinčiakova, 4th floor, No 407
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1st week (16.-18.9.09)
Lecture: Introduction to the study of Clinical Pharmacology
and Pharmacotherapy. Clinical Pharmacy.
Seminar: Organization of seminars. Basic pharmacological
knowledge for understanding of clinical
pharmacology and pharmacotherapy.
Doc. Račanská
2nd week (21.-25.9.)
Lecture: Preclinical evaluation of drugs. The preclinical stages.
Toxicological studies in preclinical evaluation of drugs.
Doc. Račanská
Seminar: Methodology of preclinical evaluation of drugs.
Preclinical disease models. Alternative models in
drug discovery and development.
Doc. Račanská
3
rd
week (28.9.-2.10.)
Lecture: Clinical evaluation of drugs. Clinical development.
Monitoring of new drugs in clinical practice.
Placebo – its importance and clinical use.
Prof. Švec
Seminar: Basic pharmacokinetic parameters in
clinical practice.
Dr. Holub
4ht week (5.-9.10.)
Lecture: European drug policy, EMEA, orphan drugs
Doc. Kuželová
Seminar: Summary Product Characteristic (SPC) and
Patient Information Leaflet (PIL).
Doc. Kuželová
5
th
week (12.-16.10.)
Lecture: Harmful effects of drugs (hepatotoxicity, nephrotoxicity,
carcinogenity, unexpected side effects…).
Unwanted effects of drugs.
Prof. Švec
Seminar: Racional pharmacotherapy – pharmacotherapeutical
risk. Pharmacotherapeutical failure.
Doc. Kuželová
6
th
week (19.-23.10.)
Lecture: Chronopharmacology and its importance in
pharmacotherapy.
Doc. Kuželová
Seminar: Pathophysiological status influencing drug response.
Influence of disease on the effects of drugs.
Dr. Ondriašová
7th week (26.-30.10)
Lecture:
Drug interactions. Types of interactions, their
characteristic, isoenzymes CYP and their clinical
importance.
Doc. Račanská
Seminar: Practical examples of some typical interactions
in therapeutical practice.
Dr. Račanská
8th week (2.-6.11.)
Lecture: Gene therapy. Technical and therapeutic aspects.
Importance of pharmacogenetics for the racional
pharmacotherapy.
Doc. Kyselovič
Seminar: Basis of the medical examination.
Basic physical examination -, palpitation, percussion,
auscultation.
Prof. Švec
9th week (9.-13.11)
Lecture:
Individual variability in pharmacotherapy I.
Specificity of pharmacotherapy in pregnancy.
Doc. Kuželová
Seminar: Over the counter drugs.
Their advantages and disadvantages.
Dr. Patráš
Doc. Račanská
10th week (16.-20.11.)
Lecture:
Individual variability in pharmacotherapy II.
Specificity of pharmacotherapy in neonatal and
pediatric patients.
Doc. Kuželová
Seminar: Abdominal pain – basic evaluation and first aid.
Chest pain and back pain – diagnosis and first aid.
Dr. Foltánová
11th week (23.-27.11.)
Lecture:
Pharmacovigilance
Basic terms for drug risk evaluation. Monitoring
of unwanted effects in clinical practice.
Dr. Patráš
Doc. Račanská
Seminar:. Generic substitution
Dr. Adameová
12th week (30.11-4.12.)
Lecture:
Humans rights and medicine.
Ethic problems and non-proved therapeutical
approaches
Prof. Švec
Seminar: FINAL TEST for getting credits.
Doc. Račanská
13th week (7.-11.12)
Tests and course evaluation, getting credits.
Doc. Račanská
14th week (14.-18.12.)
Reserve.
Credits requirements:
 Minimum 80% presence rate!
 To prepare one seminar presentation.
 To pass final test for minimum 60% rate.