1
April 28, 2010
CURRICULUM VITAE
David D. Gutterman, M.D.
Northwestern Mutual Professor of Cardiology
Senior Associate Dean for Research
HOME ADDRESS:
8025 N. Beach Dr.
Milwaukee, WI 53217
OFFICE ADDRESS:
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, Wisconsin 53226
Phone: (414) 456-8495
Fax:
(414) 456-6565
E-mail: dgutt@mcw.edu
PLACE OF BIRTH:
Bellefonte, PA
CITIZENSHIP:
U.S.A.
EDUCATION
1972 –1976
1976 –1980
B.A., Mathematics and Chemistry, University of North Carolina, Chapel Hill
M.D., University of North Carolina, Chapel Hill
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS
1980 –1982 Resident, Internal Medicine, University of Iowa Hospitals and Clinics, Iowa
City
1982 –1983 Fellow, Cardiovascular Diseases, Department of Internal Medicine, University
of Iowa Hospitals and Clinics, Iowa City
1983 –1984 Chief Resident, Internal Medicine, University of Iowa Hospitals and Clinics,
Iowa City
1984 –1986 Fellow-Associate, Cardiovascular Diseases, Department of Internal Medicine,
University of Iowa Hospitals and Clinics, Iowa City
FACULTY APPOINTMENTS (INCLUDING SECONDARY AND ADJUNCT APPOINTMENTS)
1986 –1987 Associate, Department of Internal Medicine, University of Iowa College of
Medicine, Iowa City, Iowa
1987 –1992 Assistant Professor, Department of Internal Medicine, University of Iowa
College of Medicine, Iowa City, Iowa
1992 –1998 Associate Professor, Department of Internal Medicine, University of Iowa
College of Medicine, Iowa City, Iowa
07/1998
Professor, Department of Internal Medicine, University of Iowa College of
Medicine, Iowa City, Iowa
2
08/1998
01/01/2000
07/01/2003
02/20/2004
Professor, Departments of Medicine and Physiology, Medical College of
Wisconsin, Milwaukee, WI
Northwestern Mutual Professor of Medicine, Departments of Internal
Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI
Professor, Department of Pharmacology
Professor, Epidemiology, Health Policy Institute
ADMINISTRATIVE APPOINTMENTS/
HOSPITAL AND CLINIC ADMINISTRATIVE APPOINTMENTS/
HOSPITAL STAFF PRIVILEGES
1988 – 1998 Staff Physician, VA Medical Center, Iowa City, Iowa
1997 – 1998 Chief of Cardiology, VAMC, VA Medical Center, Iowa City, Iowa
1998 –
Physician, Froedtert Memorial Lutheran Hospital, Milwaukee, WI
1998 –
Staff Cardiologist, VAMC, Milwaukee, WI
1998 – 2005 Associate Director, Cardiovascular Research Center, Medical College of
Wisconsin, Milwaukee, WI
1999 – 2005 Vice-Chair of Medicine for Research, Medical College of Wisconsin,
Milwaukee, WI
2005 –
Senior Associate Dean for Research, Medical College of Wisconsin,
Milwaukee, WI
SPECIALTY BOARDS AND CERTIFICATION
Board Certified
American Board of Internal Medicine
ABIM, Subspecialty Boards of Cardiovascular Diseases
Issue Date
06/1985
11/1987
Expiration
none
none
Licensure
Wisconsin State
Iowa State
North Carolina State
Issue Date
09/1998
04/1982
05/1980
Expiration
10/2007
09/2002
09/2006
Number
40328
22880
10261
AWARDS AND HONORS
1973
Gamma Alpha Lambda Sorority for Academic Honors, University of North
Carolina
1974
Phi Beta Kappa
1982
Individual Research Fellowship
1984 - 1986 National Research Service Award
1986
NHLBI Clinical Investigator Award
1992
American Board of Internal Medicine, Invited Preparer of Questions for
Recertification in Cardiovascular Diseases
2003
Boron Lectureship, UCLA School of Medicine, Cardiology Division
2008
Award for Most Significant Original Paper for 2008 in the category of
Clinical Science published in Hypertension [ref: Phillips SA et al 2008]
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES
1983 American Heart Association, Member
1986 American Physiological Society, Member
3
1986 1987 - 2002
1988 1988 - 2002
1989 1990 1991
1992 1994 1994 1996
2001
2004
American Federation for Clinical Research, Member
Council on Basic Sciences (AHA), Member
American College of Cardiology, Fellow (FACC)
Council on Circulation (AHA), Fellow
Laennec Society (AHA), Member
Council on Clinical Cardiology (AHA), Fellow
Central Society for Clinical Research, Member
American College of Chest Physicians, Fellow (FCCP)
American Physiological Society, Fellow
American Heart Association, Council on High Blood Pressure, Fellow
Microcirculatory Society, Member
Fellow, American Heart Association, Council on Basic Cardiovascular
Sciences
Association of University Cardiologists, Elected Member
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS
Editorships
1999 Associate Editor, American Journal of Physiology – Heart and Circulatory
Physiology
Editorial Boards
1993 - 1998 American Journal of Physiology - Heart and Circulatory Physiology
1995 - 1997 Circulation Research
2002 Circulation Research
2002 Basic Research in Cardiology
2002 Clinical Medicine & Research
2003
Atherosclerosis, Thrombosis, and Vascular Biology
2005 Journal of the CardioMetabolic Syndrome
International Advisory Board
2008 Circulation Journal
Journal Reviews
American Heart Journal
American Journal of Cardiology
Journal of the American College of Cardiology
American Journal of Physiology
Atherosclerosis, Thrombosis and Vascular Biology
Chest
Clinical and Experimental Pharmacology and Physiology
Circulation
Current Medicinal Chemistry
Developmental Neuroscience
FASEB Journal
Free Radical Biology & Medicine
Hypertension
Journal of Applied Physiology
Journal of Molecular and Cellular Cardiology
Journal of Neurochemistry
Journal of Pharmacology and Experimental Therapeutics
Journal of Vascular Research
Molecular and Cellular Biochemistry
New England Journal of Medicine
Nitric Oxide
4
Proceedings of the Society for Experimental Biology and Medicine
COLLEGIATE, UNIVERSITY, UNIVERSITY HOSPITALS, AND NATIONAL
COMMITTEES
Collegiate
1980 - 1984
1983 - 1984
1988 - 1992
1988 - 1998
1989 - 1992
1992 - 1993
1992 - 1997
1992 - 1997
1993 - 1996
1995 - 1998
1995 - 1998
1995 - 1998
1995 - 1998
1995 - 1998
1996 - 2000
1997 - 1998
1997 - 1998
199819982000
2001
2003
2003 - 2005
Resident Selection Committee
Hospital Information System Committee
VA Animal Care Committee
Fellowship Selection Committee, Cardiology Division
VA Animal Care Committee, Chairman
Promotions Committee, Department of Internal Medicine
Director of Educational Programming (Cardiology)
Clinical Research Center Protocol Review Committee, Member
VA Research and Development Committee, Member
Cardiology Division Retreat Organizer
Resource Facilities and Space Committee of Internal Medicine, Member
Faculty Advisory Committee, Member
Cardiology Fellowship Research Training Committee, Chair
Cardiology Fellowship Program, Associate Director
DERC Investigator
Chief of Cardiology at VA Medical Center, Iowa City
Cardiology Clinical Operations Group, Iowa City – member
Cardiovascular Center Executive Committee
Associate Director, Cardiovascular Center, MCW
MCW Strategic Planning Committee – member
Chair, Nephrology Chief Search Committee, MCW
Chair, Endocrinology Chief Search Committee, MCW
Co-director, Translational Research Initiative, MCW
National: National Institutes of Health
1996
NIH Study Section: Biomedical & Behavioral Research Facilities, member
1997
NHLBI Mentored Clinical Scientist Development Award Session Review
Panel, member
1998 - 1999
NIH, NHLBI Cardiovascular and Renal Study Section, special member
2000
NIH, NHLBI Cardiovascular and Renal Study Section, special member
2000
NIH, NHLBI Program Project Grant in Sickle Cell Disease Review Panel,
member
2000 - 2003
NIH NHLBI Cardiovascular and Renal Study Section, regular member
2002
Invited Member, NIH Workshop on Particulate Matter and Cardiovascular
Disease.
2002
NIH NHLBI Special Emphasis Panel for review of RFA on “Role of Infectious
Agents in Vascular Disease”, member
2003
NIH NHLBI Special Emphasis Panel, April
2003
NIH NHLBI Special Emphasis Panel, June.
2004 - 2005
NIH NHLBI CICS Study Section, Chairman
2006
NIH NHLBI Special Emphasis Panel, Chairman
2007
NIH NHLBI Conference Grant Review Panel, Member
2007
NIH NHLBI SEP (Hypertension and Microcirculation)
2007 - 2008
NIH NHLBI MIM Study Section, ad hoc Member
5
National: American College of Chest Physicians
1993 - 1996
American College of Chest Physicians, Government Liaison Committee,
Member
1997
Member, ACCP Task Force for Defining Guidelines for Treatment of
Hypertension in the Pulmonary Patient
1997 - 2000
Continuing Education Committee, American College of Chest Physicians –
member
2000- 2009
Health Science Policy Committee, American College of Chest Physicians –
member
2002
Organizing Member, American College of Chest Physicians Evidence Based
Writing Group: Pulmonary Hypertension.
2003
Abstract Reviewer: American College of Chest Physicians Annual Scientific
Meeting (CHEST).
2003
ACCP Liaison to the National Heart Attack Alert Program (NHAAP).
2003
Chair, symposium at CHEST meeting “Toy and the Heart”
2003
Member, ACCP Antithrombotic Evidence Based Guideline Committee
2003
Presenter, Annual CHEST conference:”Atrial Fibrillation Evidence Based
Guidelines: Pharmacological Therapy”
2003 - 2005
Vice-Chair, Health & Sciences Policy Committee
2004 - 2006
Chairman, Cardiovascular Disease and Hypertension Network Steering
Committee
2004 - 2007
HSP Liaison, Member of the Executive Committee, Antithrombotics Guideline
Panel
2005 - 2007
Ad hoc Member, Board of Regents
2005 - 2007
Chairman, Health & Sciences Policy Committee
2005 - 2008
Member, Scientific Programming Committee
2008 - 2011
Member, Board of Regents
2009 - 2011
Vice Chair, Ad Hoc International Education Committee
2010 - 2011
President-Elect
National: American Heart Association
1987 - 1992
AHA Research Committee (Iowa Affiliate)
1988 - 1998
AHA (Iowa) Board of Directors, Member
1988 - 91; -94 Abstract Reviewer for AHA National Scientific Meeting
1989 Co-Chair, Abstract Session, AHA National Scientific Sessions
1989 - 1990
AHA-I Research Committee, Vice Chairman
1990 - 1992
AHA-I Research Committee, Chairman
1990 Principal Organizer - Postgraduate Seminar "Advances in the Understanding of
Neural Control of the Coronary Circulation," AHA National Meeting
1991 - 1998
AHA I Executive Committee, Member
1991 - 1998
Nominating Committee (AHA-I), Member
1992
Melvin L. Marcus Young Investigator Award Selection Committee, Member
1992 - 1994
Chairman, Program Committee, AHA-Iowa Affiliate
1992 - 1994
President Elect, AHA-Iowa Affiliate
1993
Moderator, Cardiovascular Conference "Diabetes and Heart Disease", AHA
National Scientific Sessions, November 7, 1993
1994 - 1996
President, AHA - Iowa Affiliate
1995
Delegate to National Delegate Assembly - American Heart Association
1996
Organizer, AHA Scientific Sessions Cardiovascular Seminars, “New Advances
in Coronary Microvascular Control - Focus on the Human Coronary
Circulation”
1996 - 2000
Delegate to National Delegate Assembly for Council on Circulation American Heart Association
6
1997
1997
1998 - 2000
2001 - 2004
2001 - 2004
20022006 - 2007
2006 - 2009
2007 - 2009
2009 – 2012
AHA Scientific Sessions: Program Committee member for Circulation and
ATVB Councils
Team Leader - Intercouncil Categories for AHA 70th Scientific Session
Abstract Grading and Assignments
Council on Circulation – Program Committee, member
Co-Chair Programming Committee for Scientific Sessions, Council on Basic
Cardiovascular Sciences
Invited Chair, Oral abstract presentation session, Annual Scientific Sessions
Abstract Reviewer: American Heart Association, Annual Scientific Sessions
Vice-Chair, Basic and Cardiovascular Science Council
Member, Scientific Publishing Committee
Chair, Scientific Publications Committee
Member, Scientific Sessions Program Committee
AHA Study Sections
1991 - 1994
AHA Western Consortium Peer Review Committee (Member)
1996 - 1999
Midwest AHA Affiliate Grant Study Section, member
1996 - 1999
National AHA Clinical and CV Physiology Section, member
1997 - 1999
Chair, American Heart Association Midwest Peer Review Consortium (study
section on Integrative Pathophysiology, Anesthesia, Radiology, Clinical
Cardiology and Development).
1998National American Heart Association Peer-Review Group,Cell Physiology
section, member
2003
Donald W. Reynolds Foundation Cardiovascular Clinical Research Center Peer
Review Committee, Member
National: American Physiological Society
1990 Chair, Abstract Session, FASEB Meeting (Invited)
1996 - 1998
Public Affairs Committee, American Physiological Society, Member
1998
APS representative to FASEB consensus conference on NIH funding (12/98)
1999 Chair of Industry Liaison Committee, American Physiological Society –
Cardiovascular Section
1999 Member, Executive Committee, American Physiological Society –
Cardiovascular Section
2001
Chair, Symposium on “Potassium Channels that Regulate Vascular Tone:
Which are the Major Players?”, FASEB,
2004 - 2006
American Physiological Society, Public Affairs Committee member
2004 - 2007
Chairman, Cardiovascular Section, APS
2008 - 2010
Member, Publications Committee
2009 - 2012
APS representative on the FASEB Publications and Communications
Committee
Other
1991 - 1998
1991 1993
1994
1995 - 1998
1995 - 1998
1997 - 1998
1997 - 1998
Senator Tom Harkin's Health and Human Services Appropriations Committee,
Advisory Committee Member
American College of Cardiology Key Contact Program - Government
Relations Committee, Member
External Reviewer for SUNY-Buffalo Internal Medicine Promotions Committee
External Reviewer: Lady Davis Fellowship Award, Ministry of Health, Israel
Iowa Physiological Society, Treasurer
State Health Care Liaison for Iowa, American College of Chest Physicians
Chair, Government Relations Committee, American College of Cardiology,
Iowa Chapter
Chair, Iowa Physiological Society Networking Committee
7
1998
2000
2004 2007
Grant reviewer, National Heart Foundation of New Zealand
Abstract Reviewer, International Society of Hypertension 18th Scientific
Sessions.
Abstract Reviewer: American College of Cardiology
VAMC – Career Development Program Reviewer
CLINICAL ACTIVITIES
Inpatient:
Cardiology Inpatient Wards – VA Medical Center, Milwaukee
Coronary Care Unit – VA Medical Center, Milwaukee
Cardiology Consult Service – VA Medical Center, Milwaukee
Cardiology Outpatient Clinics – VA Medical Center, Milwaukee
Cardiology Outpatient Clinics – Froedtert Memorial Lutheran Hospital
Other:
Electrocardiography Station – FMLH
Consultant Service – FMLH
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS
Active
Peer Review
Title:
Flow-Mediated Dilation of Human Coronary Arterioles
Source:
NIH/NHLBI (R01 HL080704)
Role:
Principal Investigator
Dates:
1/1/2006 – 12/31/2010
Funds:
$1,250,000
Title:
Source:
Role:
Dates:
Funds:
Clinical Research Curriculum Award
NIH K30 (HL04112-01)
Program Faculty (PI: Dunn)
1/1/2006 – 12/31/2011
$1,750,000
Title:
Source:
Role:
Dates:
Funds:
Role of IKCa Channels in Vascular Remodeling
NIH/NHLBI (R01 HL080173-01)
Co-Investigator, 10% (PI: Miura)
7/1/2007 – 6/30/2012
$1,125,000
Title:
Source:
Role:
Dates:
Funds:
Mechanisms of exertional hypertension and vascular dysfunction
1K23 HL085614
Mentor (PI: Phillips)
7/1/2007 – 6/30/2012
$110,000
Title
Source:
Role:
Dates:
Funds:
Vascular dysfunction and oxidative stress in primary amyloidosis
AHA Greater Midwest GIA (0855683G)
Co-Investigator, 3% (PI: Migrino)
7/1/2008 – 6/30/2010
$143,000
Title:
Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the
Human Coronary Microcirculation
NIH/NHLBI (R01 HL094971-01)
Source:
8
Role:
Dates:
Funds:
Principal Investigator
1/1/2009 – 12/31/2012
$1,250,000
Title:
Importance of Mitochondria in the Endothelial Dysfunction of Type 2
Diabetes
1K23 HL089326
Mentor (PI: Widlansky)
7/1/2009 – 6/30/2014
$120,000
Source:
Role:
Dates:
Funds:
Prior
Source:
Role:
Dates:
American Heart Association Grant-in-Aid
Associate Investigator (Iowa Heart)
07/1982 – 07/1983
Source:
Dates:
Funds:
IRF – Fellowship (University of Iowa)
1983
$15,000
Source:
Dates:
Funds:
NIH: NRSA
1984 – 1985
$35,000
Source:
Dates:
Funds:
Small Instruments Grant
1987
$8,120
Title:
Dates:
Funds:
AHA Iowa Affiliate Grant-in-Aid
1987 – 1989
$30,000
Source:
Dates:
Funds:
AHA Iowa Affiliate Grant-in-Aid
1989 – 1990
$16,500
Source:
Dates:
Funds:
NHLBI: Clinical Investigator Award
1986 – 1991
$320,000
Title:
Source:
Role:
Dates:
Funds:
Neural Control of the Coronary Circulation in Diabetes
VA Merit Review
Principal Investigator
1988 – 1991
$160,000
Source:
Role:
Dates:
Funds:
AHA Grant-in-Aid
Principal Investigator
1990 – 1993
$105,000
Title:
Mechanisms of Cardiac Pain
9
Source:
Role:
Dates:
Funds:
NIH SCOR
Co-Investigator (Co-I: Gebhart)
1990 – 1994
$500,000
Source:
Role:
Dates:
Funds:
NIH SCOR
Co-Investigator; assumed PI role 12/90 upon death of former PI, M.J. Brody
1990 – 1994
$600,000
Source:
Dates:
Funds:
AHA Iowa Affiliate Fellowship Grant (A. Goodson)
1991 – 1992
$13,200
Title:
Source:
Role:
Dates:
Funds:
Mechanisms of Coronary Vasoregulation in Diabetes Mellitus
VA Merit Review
Principal Investigator
1992 – 1997
$600,000
Source:
Dates:
Funds:
AHA Iowa Affiliate Fellowship (K. Sundaram)
1993 – 1995
$40,000
Source:
Dates:
Funds:
AHA Iowa Affiliate Fellowship (T. Abe)
1993 – 1995
$40,000
Source:
Role:
Dates:
Funds:
AHA Grant-in-Aid
Principal Investigator
1993 – 1996
$119,000
Title:
Source:
Role:
Dates:
Funds:
Mechanisms of Coronary Blood Flow Regulation in Diabetes
NIH: R01 HL51308-01A1
Co-Investigator (PI: Kevin Dellsperger)
1994 – 1998
$731,120
Source:
Dates:
Funds:
AHA Established Investigator Award
1994 – 1999
$265,000
Title:
Dates:
Funds:
AHA Iowa Affiliate Fellowship (H. Mirua)
1995 – 1997
$40,000
Source:
Role:
Dates:
Funds:
Astra-Merck Unrestricted Educational Grant For Development of ECG
Computerized Education
Co-Investigator
1996 – 1997
$23,000
Title:
Myogenic Control of the Human Coronary Microcirculation
10
Source:
Role:
Dates:
Funds:
NIH R01
Principal Investigator
1996 – 1999
$475,000
Source:
Role:
Dates:
Funds:
AHA National Grant-in-Aid
Principal Investigator
1/1/1997 – 12/31/1999
$150,000
Title:
Source:
Role:
Dates:
Funds:
Mechanism of Altered Coronary Microvascular Reactivity in Humans with
Diabetes
VA-JDF Diabetes Research Center
Principal Investigator (Project 2)
1/1/1997 – 12/31/2001
$260,000
Source:
Role:
Dates:
Funds:
AHA-W Affiliate Fellowship
Supervisor for Ken Terata
7/1/1998 – 6/30/2000
$40,000
Title:
Source:
Role:
Dates:
Funds:
Reduced NO-mediated Vasodilation in Human Coronary Arterioles
NIH R01
Principal Investigator
1998 – 2002
$923,000
Title:
Source:
Role:
Dates:
Funds:
Mechanism of Flow-Mediated Vasodilation in the Human Coronary Circulation
VA Merit Review
Principal Investigator
1998 – 2003
$300,000
Source:
Role:
Dates:
Funds:
AHA-National Scientist Development Grant
Supervisor of Yanping Liu, MD PhD
1/1/2000 – 12/31/2004
$240,000
Source:
Role:
Dates:
Funds:
AHA-W Affiliate Fellowship
Supervisor for Atsushi Sato
7/1/2000 – 6/30/2003 (one year competitive renewal)
$50,000
Title:
Source:
Dates:
Funds:
Oxidant Stress and Human Coronary Microvascular Function
NIH R01 (relinquished for SCOR grant described below)
2000 – 2004
$1,120,000
Title:
Source:
Role:
Dates:
Funds:
Ischemic Heart Disease in African Americans
NIH SCOR
Principal Investigator; Project Leader Project #2
2000 – 2005
$6,000,000 ($1,200,000 - project 2)
11
Title:
Source:
Role:
Dates:
Funds
Vascular Signaling by Free Radicals PI
NIH PPG
Project Leader, Project #2 (PI: Harder)
4/1/2002 – 3/31/2007 (in one year extension)
$1,000,000 (project #2)
Source:
Role:
Dates:
Funds:
AHA-W Affiliate Fellowship
Supervisor for Hong-Wei Li
7/1/2002 – 6/30/2003
$50,000
Source:
Role:
Dates:
Funds:
AHA Affiliate Grant-in-Aid
Supervisor of Hiroto Miura, MD, PhD, PI
1/1/2003 – 12/31/2005
$150,000
Title:
Source:
Role:
Dates:
Funds:
Effect of Hyperglycemia on Potassium Channel function
NIH R01
Principal Investigator
4/1/2003 – 3/31/2007
$1,000,000 (in one year extension)
Title:
Source:
Role:
Dates:
Funds:
Redox Mechanisms in the Vascular Dysfunction of Inflammatory Bowel
Disease
AHA Fellowship Award – Wisconsin Affiliate
Supervisor of Ossama Abu-Hatoum, MD: PI
7/1/2003 – 6/30/2005
$60,000
Title:
Source:
Role:
Dates:
Funds
Role of Reactive Oxygen Species in Flow-Mediated Vasodilation
NIH R01
Principal Investigator
2003 – 2008
$1,000,000 (declined due to receipt of PPG - percentile score of 2.0%)
Title:
Source:
Role:
Dates:
Funds:
Role of Epoxyeicosotrienoic Acid as EDHF in Human Coronary Arterioles
VA Merit Review
Principal Investigator
1/1/2004 – 1/15/2009
$650,000
Source:
Role:
Dates:
Funds:
AHA Fellowship Award – Wisconsin Affiliate
Supervisor of Brandon Larsen, MSTP student
7/1/2005 – 6/30/2007
$65,000
Source:
Role:
Dates:
Funds:
Soy Health Research Program for the United Soybean Board “Seed grant”
Principal Investigator (Co-I: Phillips)
12/1/2006 – 11/30/2007
$10,000
MEDICAL COLLEGE TEACHING ACTIVITIES
Type of Activity: Cardiovascular Seminar, Co-director
12
Year:
1986 – 1998
Weeks per Year: 50; Hours per Week: 2
Type of Activity: Director, Cardiology Grand Rounds
Year:
1988
Weeks per Year: 15; Hours per Week: 2
Type of Activity: Coronary Physiology Journal Club
Year:
1986
Weeks per Year: 50; Hours per Week: 1.5
Type of Activity: MCW Cardiology Grand Rounds
Year:
1998
Type of Activity: MCW Internal Medicine Grand Rounds
Year:
1999
EXTRAMURAL TEACHING
Course Title: Introduction to Clinical Medicine (Lecture on Heart Sounds and Cardiac
Auscultation to M2s) (4 Hour Lecture)
Year:
1989 – 1991; 1993 - 1999
Course Title: Course in Vascular Biology (36 hour comprehensive course in vascular biology
for graduate students and post-doctoral fellows focusing on the coronary
circulation) – Technion Institute of Technology, Haifa, Israel
Year
2005- present
CLINICAL TEACHING (IN WARD, CLINIC, OR OPERATING ROOM)
Where Occurred: Introduction to Clinical Medicine (M2 Physical Exam Teaching)
Year:
1985, 1987, 1990, 1991, 1993, 1996
Weeks per Year: 6; Hours per Week: 8
Where Occurred: General Medicine Ward
Year:
1986 - present
Weeks per Year: 4; Hours per Week: 30
Where Occurred: VA Cardiology Clinic
Year:
1986 - present
Weeks per Year: 48; Hours per Week: 5
TEACHING COMMITTEES
Name: Chairman, Cardiology Subcommittee on Fellowship Training Assessment and
Continuing Education
Year:
1989 – 1998
Name:
Year:
Chairman, Cardiology Fellowship Research Training Committee
1995 – 1998
STUDENT COUNSELING/
SUPERVISION OF RESEARCH
Program Name: MSTP (MD/PhD) Program
Brandon Larsen (2004 – )
13
Program Name: Graduate Student Thesis Supervision
Student/Years: Paul Rogers (2005 – 07)
Yuttana Chawengsub (2006 – 08)
Lauren Olsen (2007 – )
Jason E. Maas (2009 – )
Program Name: Medical College of Wisconsin Honors Program
Student/Years: Jackie Kulinski (2005 – 08)
Program Name: University of Iowa Honors Program
Students/Years: Jennifer Bocker (1992 – 95)
Corey Ingram (1993)
Neelay Kothari (1995 – 96)
Program Name: Undergraduate Scholarship Assistance Program
Students/Years: Peter Pardubsky (1987 – 90)
Michael Pettersen (1989 – 90)
Melanie Danehy (1989 – 91)
Michael Breu (1994 – 96)
Rohit Sahai (1995 – 97)
Program Name: AHA Medical Student Fellowship
Students/Years: Francis Miller (1988 – 89)
Dan McDermott (1990 – 91)
Angie Cave (1991 – 92)
Eduardo Rodriguez (1994 – 95)
Jennifer Bocker (1995 – 96)
Sheree Murphy (1996 – 97)
Brian Rupert (1997)
Program Name: Summer Research Experience Program
Students/Years: Amy Sung (1996)
Joseph Williams (1996)
Sarvenaz Jabbari (1997)
Program Name: Postdoctoral
Students/Years: Peter Pardubsky (Predoctoral Fellow; 1986 – 90)
Angie Goodson (Predoctoral Fellow; 1987 – 91)
John Stuhlmuller, MD (1988 – 89)
Francis Miller, MD (1988-89; 1992 – 96)
Robert Paul, MD (1988 – 90)
Stephan DeBoel, MD (1988 – 91)
James Quillen, MD (1990 – 91)
Robyn Foy, PhD (1993 – 94)
Toyohiko Abe, MD, PhD (1993 – 95)
Kalyana Sundarum, MD (1993 – 97)
Hiroto Miura, MD, PhD (1995 – 98)
Ken Terata, MD, PhD (1997 – 2000)
Atsushi Sato, MD, PhD (2000)
Jason Clyne, MS (Master’s Degree Marquette U; 2001 – 2003)
Ossama Abu-Hatoum, MD (2001 – 2004)
Nauman Siddiqi, MD (Master’s Candidate; 2002 – 2003)
Francisco Soto, MD (Master’s Candidate; 2003)
Cevher Ozcan, MD (Medicine Resident; 2003 – 2004)
14
Shane Phillips, PhD (2004 – 2005)
Anna Knight (2004 – 2006)
Program Name: Medical Student Research Summer Program
Students/Years: Tim LaMaster (1989)
Ian Law (1990)
Rafael Lupercio (1990)
Yasemin Murad (1990)
Peter Pardubsky (1990)
Angie Goodson (1992)
Stacey George (1997)
Eric Scott (1997)
Megan Staten (1999)
Alissa Garman (1999, 2000)
Susan Pitt (2001-2002)
Tamara McArthur (2003)
Pui Lai (2008)
Program Name: Others Supervised
Students/Years: Angie Cave (1988 – 90)
Corrine Barber (1988 – 90)
Michelle Weinrieich (1991)
Mark Richardson (1991 – 92)
Jim Cook (1992 – 93)
Eric Scott (1993 – 97)
Kristen Beasley (1996 – 97)
Sean Johnson (1996 – 98)
Lisa Evoy (1996 – 98)
Jill Prader (1996 – 98)
Sam Kang (1997 – 98)
Luann Eberhart (1999 – 2000)
John Bosnjak (2000 – 04)
Elana Rudman (2003)
EDUCATIONAL GRANTS
Title/Source:
Educational Grants: Cardiology Grand Rounds
Dates:
1990 - 2002
Funds:
$260,000
Title/Source:
Dates:
Funds:
Grants for Fellowship Training
1991 - 2001
$41,300
Title/Source:
Dates:
Funds:
Grants for Internal Medicine Research Day
2001 $29,000
BIBLIOGRAPHY
REFEREED JOURNAL PUBLICATIONS/ORIGINAL PAPERS
1. Gutterman DD, Rusch NJ, Hermsmeyer K, Dole WP: Differential Reactivity to 5Hydroxytryptamine in Canine Coronary Arteries. Blood Vessels. 23:165-172, 1986.
15
2. Gutterman DD, Chilian WM, Eastham CL, Inou T, White CW, Marcus ML: Failure of
Pyruvate to Salvage Myocardium after Prolonged Ischemia. Am J Physiol. (Heart Circ. Physiol.)
19(1):H114-H120, 1986.
3.
Bonham AC, Gutterman DD, Arthur JA, Marcus ML, Gebhart GF, Brody MJ. Electrical
Stimulation in Pericortical Lateral Hypothalamus Decreases Coronary Blood Flow in Cat. Am J
Physiol. 252:H474-H484, 1987.
4.
Bonham AC, Gutterman DD, Arthur JM, Marcus ML, Gebhart GF, Brody MJ. Neurogenic
Regulation of Coronary Blood Flow: Evidence for a Central Nervous System Pathway. Circ
Res. 61(Suppl. II):II-42-II-46, 1987.
5. Gutterman DD, Bonham AC, Arthur JM, Gebhart GF, Marcus ML, Brody MJ.
Characterization of a coronary vasoconstrictor site in medullary reticular formation. Am J
Physiol 1989 Apr;256(4 Pt 2):H1218-27.
6. Gutterman DD, Bonham AC, Gebhart GF, Marcus ML, Brody MJ. Connections between
Hypothalamus and Medullary Reticular Formation Mediate Coronary Vasoconstriction. Am J
Physiol. 259:H917-H924, 1990.
7. Arthur JM, Bonham AC, Gutterman DD, Gebhart GF, Marcus ML, Brody MJ. Coronary
Vasoconstriction During Stimulation in the Hypothalamic Defense Region. Am J Physiol.
260:R335-R345, 1991.
8. Gutterman DD, Pardubsky PD, Clothier JL, Marcus ML, Brody MJ. Coronary
Vasoconstriction in Response to Epicardial Hypothermia. Coronary Artery Disease. 2:75-86,
1991.
9. Gutterman DD, Gebhart GF, Pardubsky PD, Clothier J, Arthur SA, Marcus ML, Brody MJ.
Role of Medullary Lateral Reticular Formation in Baroreflex Coronary Vasoconstriction. Brain
Res. 557:202-209, 1991.
10. Miller FM, Brody MJ, Marcus ML, Gutterman DD. Activation in the region of Parabrachial
Nucleus Elicits Neurogenically Mediated Coronary Vasoconstriction. Am J Physiol.
261:H1585-1596, 1991.
11. Jones LF, Gutterman DD, Brody MD. Patterns of Hemodynamic Responses Associated with
Central Activation of Coronary Vasoconstriction. Am J Physiol. 262:R276-R283, 1992.
12. Gutterman DD, Morgan DA, Miller FM. Effect of Brief Myocardial Ischemia on Sympathetic
Coronary Vasoconstriction. Circ Res 71:960-969, 1992.
13. Ben-Haim SA, Becker B, Gutterman DD, Kaplinsky E, Palti Y. Prediction of Immediate
Ventricular Arrhythmias Following Coronary Artery Ligation. J Am Coll Cardiol. 20(5):12701276, 1992.
16
14. DeBoel SL, Gutterman DD. Coronary Vascular Response to Cerebral Ischemia Reflex.
Hypertension. 21:216-221, 1993.
15. Goodson AR, LaMaster TS, Gutterman DD. Coronary Vasoconstrictor Pathway from Anterior
Hypothalamus Includes Neurons in Rostroventrolateral Medulla. Am J Physiol. 265:R1311R1317, 1993.
16. Goodson AR, Leibold JM, Gutterman DD. Inhibition of Nitric Oxide Synthesis Augments
Centrally-Induced Sympathetic Coronary Vasoconstriction in Cats. Am. J. Physiol. 267:H12721278, 1994.
17. Pettersen MD, Abe T, Morgan DA, Gutterman DD. Role of Adenosine in Postischemic
Dysfunction of Coronary Innervation. Circ Res. 76:95-101, 1995.
18. Scott I, Gutterman DD. Pheochromocytoma with Reversible Focal Cardiac Dysfunction. Am
Heart J. 130(4):909-911, 1995.
19. Gutterman DD, Morgan DA. Transmural Regulation of Myocardial Perfusion by Neuropeptide
Y. Basic Res. Cardiol. 90:348-355, 1995.
20. McDermott DA, Meller ST, Gebhart GF, Gutterman DD. Use of an Indwelling Catheter for
Examining Cardiovascular Reponses to Pericardial Administration of Bradykinin in Rat.
Cardiovascular Research. 30(1):39-46, July, 1995.
21. Gutterman DD, Goodson AR. The Role of Parabrachial Nucleus in Baroreflex Mediated
Coronary Vasoconstriction. Am J Physiol. 271:H1079-H1086, 1996.
22. Abe T, Morgan DA, Gutterman DD. Role of Adenosine Receptor Subtypes in Neural Stunning
of the Sympathetic Coronary Innervation. Am J Physiol. 272:H25-H34, 1997.
23. Abe T, Morgan DA, Gutterman DD. Protective Role of Nerve Growth Factor Against
Postischemic Dysfunction of Sympathetic Coronary Innervation. Circulation. 95:213-220, 1997.
24. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD. Myogenic Constriction of Human
Coronary Arterioles. Am J Physiol. 273: H257-H264, 1997.
25. Miura H, Morgan DA, Gutterman DD. Oxygen-Derived Free Radicals Contribute to Neural
Stunning in the Canine Heart. Am J Physiol. 273:H1569-H1575, 1997.
26. Oltman C, Gutterman DD, Scott EC, Bocker JM, Dellsperger KC. Effects of glycosylated
hemoglobin on vascular responses in vitro. Cardiovasc Res 1997 Apr;34(1): 179-84.
27. Gutterman DD, Pardubsky PD, Pettersen M, Marcus ML, Gebhart GF. Thoracic spinal neuron
response to repeated myocardial ischemia and epicardial bradykinin. Brain Res 1998 Apr
20;790(1-2):293-303.
17
28. Miller FJ Jr, Dellsperger KC, Gutterman DD. Pharmacologic activation of the human coronary
microcirculation in vitro: endothelium-dependent dilation and differential responses to
acetylcholine. Cardiovasc Res 1998 Jun;38(3):744-50.
29. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in
vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis.
Circ Res. 1998 Jun 29;82(12):1298-305.
30. Abe T, Morgan D, Sengupta JN, Gebhart GF, Gutterman DD. Attenuation of ischemia-induced
activation of cardiac sympathetic afferents following brief myocardial ischemia in cats. J Auton
Nerv Syst. 1998 Jun 30;71(1):28-36.
31. Miura H, Gutterman DD. Human coronary arteriolar dilation to arachidonic acid depends on
cytochrome P-450 monooxygenase and Ca2+-activated K+ channels. Circ Res 1998 Sep
7;83(5):501-7.
32. Miura H, Liu Y, Gutterman DD. Human coronary arteriolar dilation to bradykinin depends on
membrane hyperpolarization: contribution of nitric oxide and Ca2+-activated K+ channels.
Circulation 1999 June 22;99(24):3132-8.
33. Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA. Acetylcholineinduced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve
dysfunction. Br J Pharmacol 1999 Oct;128(3):837-43. PMCID: PMC1571695
34. Oltman CL, Kane NL, Gutterman DD, Bar RS, Dellsperger KC. Mechanism of coronary
vasodilation to insulin and insulin-like growth factor I is dependent on vessel size. Am J Physiol
Endocrinol Metab 2000 Jul; 279(1):E176-81.
35. Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC. Free radicals mediate endothelial
dysfunction of coronary arterioles in diabetes. Cardiovasc Res 2000 Aug 18;47(3):595-601.
36. Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC. Impaired dilation of coronary
arterioles during increases in myocardial O2 consumption with hyperglycemia. Am J Physiol
Endocrinol Metab 2000 Oct;279(4):E868-74.
37. Terata K, Miura H, Liu Y, Loberiza F, Gutterman DD. Human coronary arteriolar dilation to
adrenomedullin: role of nitric oxide and K(+) channels. Am J Physiol Heart Circ Physiol 2000
Dec;279(6):H2620-6.
38. Miura H, Wachtel RE, Liu Y, Loberiza FR Jr, Saito T, Miura M, Gutterman DD. Flow-induced
dilation of human coronary arterioles: important role of Ca(2+)-activated K(+)-channels.
Circulation 2001 Apr 17;103(15):1992-8.
39. Nair BA, Murad YZ, Brody MJ, Gutterman DD. Ouabain-induced coronary vasoconstriction in
cats is not neurally mediated. Clin Exp Pharmacol Physiol 2001 Jul;28(7):510-7.
18
40. Bocker JM, Miller FJ, Oltman CL, Chappell DA, Gutterman DD. Calcium-activated potassium
channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta.
Japanese Heart J 2001 May;42(3):317-26.
41. Liu YP, Terata K, Rusch NJ, Gutterman DD. High glucose impairs voltage-gated K(+) channel
current in rat small coronary arteries. Circ Res 2001 Jul 20;89(2):146-52.
42. Sato A, Miura H, Liu Y, Somberg LB, Otterson MF, Demeure MJ, Schulte WJ, Eberhardt LM,
Loberiza FR, Sakuma I, Gutterman DD. Effect of gender on endothelium-dependent dilation to
bradykinin in human adipose microvessels. Am J Physiol Heart Circ Physiol 2002
Sep;283(3):H845-52.
43. Liu Y, Terata K, Chai Q, Li H, Kleinman LH, Gutterman DD. Peroxynitrite inhibits Ca2+activated K+ channel activity in smooth muscle of human coronary arterioles. Circ Res 2002 Nov
29;91(11):1070-6.
44. Dart RA, Gregoire JR, Gutterman DD, Woolf SH. The association of hypertension and
secondary cardiovascular disease with sleep-disordered breathing. Chest 2003 Jan;123(1):24460.
45. Miura H, Wachtel RE, Loberiza, FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD.
Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity
of ATP-sensitive potassium channels. Circ Res 2003 Feb 7;92(2):151-8.
46. Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD. Role for hydrogen peroxide
in flow-induced dilation of human coronary arterioles. Circ Res 2003 Feb 7;92(2):e31-40.
47. Hoch AZ, Dempsey RL, Carrera GF, Wilson CR, Chen EH, Barnabei VM, Sandford PR, Ryan
TA, Gutterman DD. Is there an association between athletic amenorrhea and endothelial cell
dysfunction? Med Sci Sports Exerc, 2003 Mar;35(3):377-83.
48. Bosnjak JJ, Terata K, Miura H, Sato A, Nicolosi AC, McDonald M, Manthei SA, Saito T,
Hatoum OA, Gutterman DD. Mechanism of thrombin-induced vasodilation in human coronary
arterioles. Am J Physiol Heart Circ Physiol 2003 Apr;284(4): H1080-6.
49. Ou J, Ou Z, Jones DW, Holtzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman
DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr. L-4F, an apolipoprotein A-1 mimetic,
dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. Circulation
2003 May;107(18):2337-41.
50. Hatoum OA, Binion DG, Otterson MF, Gutterman DD. Acquired microvascular dysfunction in
inflammatory bowel disease: loss of nitric oxide-mediated vasodilation. Gastroenterology 2003
Jul;125(1):58-69.
19
51. Peles S, Petersen J, Aviv R, Policker S, Abu-Hatoum O, Ben-Haim SA, Gutterman DD,
Sengupta JN. Enhancement of antral contractions and vagal afferent signaling with synchronized
electrical stimulation. Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G577-85.
52. Li H, Chai Q, Gutterman DD, Liu Y. Elevated glucose impairs cAMP-mediated dilation by
reducing Kv channel activity in rat small coronary smooth muscle cells. Am J Physiol Heart
Circ Physiol 2003 Sep;258(3):H1213-9.
53. Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD. Mitochondrial sources of
H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries.
Circ Res 2003 Sep 19;93(6):573-80.
54. Oltman CL, Clark CB, Kane NL, ZhangY, Gutterman DD, Dellsperger KC, Kerber RE.
Coronary vascular dysfunction associated with direct current shock injury. Basic Res Cardiol
2003 Nov;98(6):406-15.
55. Sato A, Sakuma I, Gutterman DD. Mechanism of dilation to reactive oxygen species in human
coronary arterioles. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2345-54.
56. McGoon M, Gutterman DD, Steen V, Barst RJ, McCrory DC, Fortin TA, Loyd JE. Screening,
early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical
practice guidelines. Chest 2004 Jul;126(1 Suppl):14S-34S
57. Stein PD, Schünemann HJ, Dalen JE, Gutterman DD. Antithrombotic therapy in patients with
saphenous vein and internal mammary artery bypass grafts: the Seventh ACCP Conference on
Antithrombotic and Thrombolytic Therapy. Chest 2004 Sep;126(3 Suppl):600S-608S.
58. Li H, Gutterman DD, Rusch NJ, Bubolz A, Liu Y. Nitration and functional loss of voltagegated K+ channels in rat coronary microvessels exposed to high glucose. Diabetes 2004
Sep;53(9):2436-42
59. Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, Gutterman DD. Role of hydrogen
peroxide in ACh-induced dilation of human submucosal intestinal microvessels. Am J Physiol
Heart Circ Physiol 2005 Jan; 288(1): H48-54.
60. Slyper A, Jurva J, Pleuss J, Hoffmann R, Gutterman DD. Influence of glycemic load on HDL
cholesterol in youth. Am J Clin Nutr 2005 Feb;81(2):376-9.
61. Sato A, Terata K, Miura H, Toyama K, Loberiza FR Jr, Hatoum OA, SaitoT, Sakuma I,
Gutterman DD. Mechanism of vasodilation to adenosine in coronary arterioles from patients
with heart disease. Am J Physiol Heart Circ Physiol 2005 Apr;288(4):H1633-40.
62. Slyper A, Le A, Jurva J, Gutterman DD. The influence of lipoproteins on whole-blood
viscosity at multiple shear rates. 2005 Jun;54(6):764-8.
20
63. Hogue CW Jr, Creswell LL, Gutterman DD, Fleisher LA. Epidemiology, mechanisms, and
risks: ACCP guidelines for the prevention and management of post-operative atrial fibrillation
after cardiac surgery. Chest. 2005 Aug;128(2 Suppl):9S-16S.
64. Epstein AE, Alexander JC, Gutterman DD, Maisel W, Wharton JM. Anticoagulation: ACCP
guidelines for the prevention and management of postoperative atrial fibrillation after cardiac
surgery. Chest 2005 Aug;128(2 Suppl):24S-27S.
65. Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB,
Gutterman DD. Novel mechanism of vasodilation in inflammatory bowel disease. ATVB 2005
Nov;25(11):2355-61.
66. Hatoum OA, Binion DG, Phillips SA, O’Loughlin C, Komorowski RA, Gutterman DD,
Otterson MF. Radiation induced small bowel “web” formation is associated with acquired
microvascular dysfunction. Gut 2005 Dec;54(12):1797-800. PMCID: PMC1774807
67. Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD. Peroxynitrite reduces
the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in
PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R57-65.
68. Guyatt G, Gutterman DD, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G,
Lewis SZ, Schünemann H. Grading strength of recommendations and quality of evidence in
clinical guidelines: report from an American College of Chest Physicians task force. Chest.
2006 Jan;129(1): 174-81.
69. Guyatt G, Baumann M, Pauker S, Halperin J, Maurer J, Owens DK, Tosteson AN, Carlin B,
Gutterman DD, Prins M, Lewis SZ, Schünemann H. Addressing resource allocation issues in
recommendations from clinical practice guideline panels: suggestions from an American
College of Chest Physicians task force. Chest. 2006 Jan;129(1):182-7.
70. Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR,
Gutterman DD. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary
arterioles via BKCa channels: implications for soluble epoxide hydrolase inhibition. Am J
Physiol Heart Circ Physiol 2006 Feb;290(2): H491-9. PMCID: PMC1456013
71. Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder
JE, Gutterman DD. Radiation induces endothelial dysfunction in murine intestinal arterioles via
enhanced production of reactive oxygen species. ATVB 2006 Feb;26(2):287-94.
72. Dedkov EI, Perloff JK, Tomanek RJ, Fishbein MC, Gutterman DD. The coronary
microcirculation in cyanotic congenital heart disease. Circulation 2006 Jul 18;114(3):196-200.
73. Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD. The effect of
exertional hypertension evoked by weight lifting on vascular endothelial function. JACC 2006
Aug 1;48(3):588-9.
21
74. Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M.
Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary
and coronary vasculature. Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31.
75. Phillips SA, Hatoum OA, Gutterman DD. The mechanism of flow-induced dilation in human
adipose arterioles involves hydrogen peroxide during CAD. Am J Physiol Heart Circ Physiol
2007 Jan;292(1):H93-100.
76. Baumann MH, Lewis SZ, Gutterman DD. ACCP evidence-based guideline development: a
successful and transparent approach addressing conflict of interest, funding, and patient-centered
recommendations. Chest 2007 Sep;132(3): 1015-24.
77. Bubolz AH, Wu Q, Larsen BT, Gutterman DD, Liu Y. Ebselen reduces nitration and restores
voltage-gated potassium channel function in small coronary arteries of diabetic rats. Am J
Physiol Heart Circ Physiol 2007 Oct;293(4): H2231-7.
78. Hoch AZ, Jurva JW, Staton MA, Thielke R, Hoffmann RG, Pajewski N, Gutterman DD.
Athletic amenorrhea and endothelial dysfunction. WMJ 2007 Sep;106(6):301-6.
79. Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, Hoffmann RG, Gutterman
DD. Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension
2008 Feb;51(2):376-82. PMCID: PMC2702133. Winner of the Award for Most Significant
Original Paper for 2008 in the category of Clinical Science.
80. Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck
JR, Miura H. Hydrogen peroxide inhibits cytochrome P450 epoxygenases: interaction between
two endothelium-derived hyperpolarizing factors. Circ Res 2008 Jan 4;102(1): 59-67. PMCID:
PMC2364729
81. Mio Y, Bienengraeber MW, Marinovic J, Gutterman DD, Rakic M, Bosnjak ZJ, Stadnicka A.
Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for
mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel
activity. Anesthesiology 2008 Apr;108(4):612-20. PMCID: PMC2697447
82. Liu Y, Li H, Bubolz AH, Zhang DX, Gutterman DD. Endothelial cytoskeletal elements are
critical for flow-mediated dilation in human coronary arterioles. Med Biol Eng Comput 2008
May;46(5):469-78. PMCID: PMC2702135
83. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S,
Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. The intermediateconductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice
and humans. J Clin Invest 2008 Sep;118(9):3025-37. PMCID: PMC2496961
84. Farrell RM, Syed A, Syed A, Gutterman DD. Effects of limb electrode placement on the 12and 16-lead electrocardiogram. J Electrocardiol 2008 Nov-Dec;41(6):536-45.
22
85. Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M,
Gutterman DD. Transient receptor potential vanilloid type 4-deficient mice exhibit impaired
endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension
2009 Mar;53(3):532-8. PMCID: PMC2694062
86. Hoch AZ, Pajewski NM, Hoffman RG, Schimke JE, Gutterman DD. Possible relationship of
folic acid supplementation and improved flow-mediated dilation in premenopausal,
eumenorrhiec athletic women. J Sports Science & Medicine 2009 Mar;8(1):123-9.
87. Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD. Bradykinin-induced
dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species.
ATVB 2009 May;29(5):739-45. PMCID: PMC2727937
88. Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC,
Falck JR, Gutterman DD, Jacobs ER, Medhora MM. Protective actions of epoxyeicosatrienoic
acid: Dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol. 2009
Jun;46(6):978-88. PMCID: PMC2796716
89. Migrino RQ, Hari P, Gutterman DD, Bright M, Truran S, Schlundt B, Phillips SA. Systemic
and microvascular oxidative stress induced by light chain amyloidosis. Int J Cardiol 2009 May
14. In press.
90. Hoch AZ, Pajewski NM, Moraski L, Carrera GF, Wilson CR, Hoffmann RG, Schimke JE,
Gutterman DD. Prevalence of the female athlete triad in high school athletes and sedentary
students. Clin J Sport Med. 2009 Sep;19(5):421-8. PMCID: In Process
91. Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX.
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J
Physiol Heart Circ Physiol. 2010 Feb;298(2):H466-76. PMCID: In Process
92. Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD. Folic acid supplementation
improves vascular function in amenorrheic runners. Clin J Sport Med. In Press.
EDITORIALS, LETTERS TO EDITOR, OTHER
1. Gutterman DD. Characterization of the acute left ventricular thrombus: hermit or nomad? J
Am Coll Cardiol 1989 Mar 1;13(3):565-6.
2. Gutterman DD, Ayres RW. Use of echocardiography in detecting cardiac sources of embolus.
Echocardiography 1993 Mar;10(3):311-20.
3. Lindower PD, Gutterman DD. Detection of cardioembolic sources with echocardiography.
Compr Ther 1994;20(3):174-80.
23
4. Gutterman DD. Adventitia-dependent influences on vascular function. Am J Physiol 1999
Oct;277(4 Pt 2):H1265-72.
5. Chilian WM, Gutterman DD. Prologue: new insights into the regulation of the coronary
microcirculation. Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2585-6.
6. Gutterman DD, Hume J. Potassium channels that regulate vascular tone: Which are the
important players? Clin Exp Pharm Phys 2002; 29:304.
7. Liu Y, Gutterman DD. Oxidative stress and potassium channel function. Clin Exp Pharmacol
Physiol 2002 Apr;29(4):305-11.
8. Gutterman DD. Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ
Res 2002 Jan 11;90(1):5-7.
9. Liu Y, Gutterman DD. The coronary circulation in diabetes: influence of reactive oxygen
species on K+ channel-mediated vasodilation. Vascul Pharmacol 2002 Jan;38(1): 43-9.
10. Konidala S, Gutterman DD. Coronary vasospasm and the regulation of coronary blood flow.
Prog Cardiovasc Dis 2004 Jan-Feb;46(4):349-73.
11. Wilcox CS, Gutterman DD. Focus on oxidative stress in the cardiovascular and renal systems.
Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H3-6.
12. Gutterman DD, Miura H, Liu Y. Redox modulation of vascular tone: focus of potassium
channel mechanisms of dilation.” Arterioscler Thromb Vasc Biol 2005 Apr;25(4):671-8.
13. Epstein AE, Alexander JC, Gutterman DD, Maisel W, Wharton JM. Anticoagulation: American
College of Chest Physicians guidelines for the prevention and management of postoperative
atrial fibrillation after cardiac surgery. Chest 2005 Aug;128(2 Suppl):24S-27S.
14. Gutterman DD. Mitochondria and reactive oxygen species: an evolution in function. Circ Res
2005 Aug 19;97(4):302-4.
15. Hatoum OA, Binion DG, Gutterman DD. Paradox of simultaneous intestinal ischaemia and
hyperaemia in inflammatory bowel disease. Eur J Clin Invest 2005 Oct;35(10):599-609.
16. Baumann MH, Gutterman DD. American College of Chest Physicians evidence based
guidelines--the next generation: considering resource use and evolution to a single grading
system. Chest 2006 Jan;129(1):10-2.
17. Irwin RS, Gutterman DD. American College of Chest Physicians cough guidelines. Lancet
2006 Mar 25;367(9515):981.
18. Larsen BT, Gutterman DD, Hatoum OA. Emerging role of epoxyeicosatrienoic acids in
coronary vascular function. Eur J Clin Invest. 2006 May;36(5): 293-300.
24
19. Larsen BT, Gutterman DD. Hypoxia, coronary dilation, and the pentose phosphate pathway.
Am J Physiol Heart Circ Physiol 2006 Jun;290(6): H2169-71.
20. Mayr M, Zhang J, Greene AS, Gutterman DD, Perloff J, Ping P. Proteomics-based development
of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights. Mol Cell
Proteomics 2006 Oct;5(10):1853-64.
21. Gutterman DD, Cowley AW Jr. Relating cardiac performance with oxygen consumption:
historical observations continue to spawn scientific discovery. Am J Physiol Heart Circ Physiol
2006 Dec;291(6):H2555-6.
22. Larsen BT, Campbell WB, Gutterman DD. Beyond vasodilatation: non-vasomotor roles of
epoxyeicosatrienoic acids in the cardiovascular system. Trends Pharmacol Sci 2007
Jan;28(1):32-8.
23. Zhang DX, Gutterman DD. Mitochondrial reactive oxygen species-mediated signaling in
endothelial cells. Am J Physiol Heart Circ Physiol 2007 May;292(5): H2023-31.
24. Hoch AZ, Lal S, Jurva JW, Gutterman DD. The female athlete triad and cardiovascular
dysfunction. Phys Med Rehabil Clin N Am 2007 Aug;18(3):385-400, vii-viii.
25. Gutterman DD. Combating nitrate tolerance – A novel endogenous mechanism. Arterioscler
Thromb Vasc Biol. 2007 Aug; 27(8):1673-6.
26. Pagano PJ, Gutterman DD. The adventitia: the outs and ins of vascular disease. Cardiovasc Res
2007 Sep 1;75(4):636-9. PMCID: In Process
27. Larsen BT, Zhang DX, Gutterman DD. Epoxyeicosatrienoic acids, TRP channels, and
intracellular Ca2+ in the vasculature: an endothelium-derived endothelium hyperpolarizing
factor? Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2496-8.
28. Liu Y, Gutterman DD. Vascular control in humans: focus on the coronary microcirculation.
Basic Res Cardiol 2009 Feb 3;104:211-27.
29. Gutterman DD. Silent Myocardial Ischemia. Circ J 2009 Apr 24;73(5):785-97.
30. Larsen BT, Gutterman DD. C-reactive protein: A multipronged assailant on endotheliumdependent vasodilation. J Mol Cell Cardiol 2009 Aug;47(2):177-9.
BOOKS, CHAPTERS, AND REVIEWS
1. Gutterman DD, Bonham AC, Arthur JA, Gebhart GF, Marcus ML, Brody MJ: Central Neural
Regulation of Coronary Blood Flow. In: Brain Peptides and Catecholamines in Cardiovascular
Regulation in Normal and Disease States, J.P. Buckley and C.M. Ferrario (Eds.), Raven Press,
New York, 1987.
25
2. Gutterman DD, Marcus ML: Advances in Understanding the Function of the Coronary
Circulation in Physiological and Pathological States. In: Advances In Cardiovascular Surgery,
Wechsler, A.S. (ed).
3. Gutterman DD, Bonham AC, Stuhlmuller JE, Arthur JM, Gebhart GF, Marcus ML, Brody MJ:
Central Neural Aspects of Coronary Flow Regulation. In: Analysis and Simulation of the
Cardiac System - Ischemia, Chapter 19, S. Sideman and R. Beyar (eds), CRC Press, Boca Raton,
FL, pp. 249-264, 1989.
4. Gutterman DD, Brody MJ, Marcus ML: Neural Regulation of Coronary Blood Flow. In:
Reflex Control of the Circulation, I.H. Zucker and J. Gilmore (eds), Chapter 19, CRC Press,
Boca Raton, FL, pp. 695-736, 1991.
5. Gutterman DD: Central Integration of Autonomic Control of the Heart Including the Coronary
Circulation. In: Volume IX: The Nervous Control of the Heart. J.T. Shepherd and S.F. Vatner
(eds.), Geoffrey Burnstock (Series Ed.), Harwood Acad. Publishers, Amsterdam, pp. 253-294,
1996.
6. Gutterman DD, Schnoll D: Neural Control of the Coronary Circulation. In: Volume VIII:
Nervous Control of Blood Vessels. T. Bennett and S. M. Gardiner (eds), Geoffrey Burnstock
(Series Ed.), Harwood Acad. Publishers, Amsterdam, pp. 265-304, 1996.
7. Gutterman DD, Liu Y, Frisbee JC: Reactive Oxygen Species and K+ Channel Function in
Diabetes and Insulin Resistance. In: Trends in Diabetes Research, Ford, A.(ed), Chapter 4,
Nova Science Publishers, Inc., New York, pp. 71-106, 2006.
8. Harrington, RA, Becker RC, Cannon CP, Gutterman DD, Lincoff AM, Popma JJ, Steg G,
Guyatt GH, Goodman SG, American College of Chest Physicians. Antithrombotic therapy for
non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians
Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008 Jun;133(6 Suppl):670S707S.
ABSTRACTS
1. Gutterman DD, Chilian WM, Eastham CL, Inou T, Bohling BA, Marcus ML, White CW:
Failure of Intracoronary Pyruvate to Salvage Myocardium after Three Hours of Myocardial
Ischemia. Fed Proc, 42:1093, 1983.
2. Gutterman DD, Rusch NJ, Hermsmeyer RK, Dole WP: Differential Reactivity of Large and
Small Coronary Arteries to 5-Hydroxytryptamine. Fed Proc, 43:3597, 1984.
3. Gutterman DD, Bonham AC, Arthur JM, Gebhart GF, Marcus ML, Brody MJ: Coronary
Vasoconstriction to Stimulation in Brainstem Regions Receiving Nociceptive Afferent Input
Fed Proc, 44(3):622, 1985.
26
4. Bonham AC, Arthur GF, Marcus JM, Gebhart ML, Brody MJ. Lateral hypothalamus (LH)-A
central site for neurally mediated coronary vasoconstriction.
5. Arthur JM, Bonham AC, Gebhart GF, Marcus ML, Brody MJ. Stimulation in the anteromedial
hypothalamus in the area of the paraventricular nucleaus produces coronary vasoconstriction.
6. Bonham AC, Wilkin LD, Arthur JM, Gutterman DD, Gebhart GF, Marcus ML, Brody MJ:
Brainstem Efferents from a Lateral Hypothalamic Site Which Produces a Decrease in Coronary
Blood Flow. The Physiologist, 28(4):275, 1985.
7. Gutterman DD, Gebhart GF, Arthur JM, Bonham AC, Marcus ML, Brody MJ: FrequencyDependent Selective Activation of Coronary Vasoconstriction by Electrical Stimulation in
Brainstem. Clin Res, 33(4):806A, 1985.
8. Gutterman DD, Bonham AC, Gebhart GF, Marcus ML, Brody MJ: Coronary Constrictor
Pathway from Lateral Hypothalamus (LH) Projects Through Ventrolateral Medulla (VLM). Fed
Proc, 45(3):397, 1986.
9. Gutterman DD, Clothier J, Brody MJ: Coronary Vasoconstriction Produced by Epicardial
Hypothermic Solutions. Circulation, 74(4):II-243, 1986.
10. Gutterman DD, Clothier J, Marcus ML, Brody MJ: Coronary Vascular Response to Epicardial
Hypothermic Solutions. Clin Res, 34(4):894A, 1986.
11. Gutterman DD, Marcus ML, Brody MJ, Miller FJ: Parabrachial Nuclear Region: An Important
Neuronal Site Mediating Coronary Vasoconstriction. Circulation, 79:II-316, 1988.
12. Gutterman DD, Miller FJ, Morgan DA: Does Myocardial Stunning Alter Neurally-Mediated
Coronary Vasoconstriction? Circulation, 78:II-555, 1988.
13. Stuhlmuller JE, Gutterman DD, Marcus ML, Gebhart GF, Brody MJ: Electrical Stimulation in
Rostral Ventrolateral Medulla of the Cat Produces Coronary Vasoconstrictor and Vasodilator
Responses. FASEB J, 2:A495, 1988.
14. Paul RK, Gutterman DD, Marcus ML, Brody MJ: Medullary Sites Projecting to Spinal
Preganglionic Neurons Mediate Coronary Constriction in Cat. Circulation, 80:II-311, 1989.
15. Gutterman DD, Pardubsky PD, Gebhart GF: Attenuation of Afferent Spinal Neuronal
Responses to Successive Coronary Occlusions May Contribute to Silent Ischemia. Circulation,
80:II-553, 1989.
16. Gutterman DD, Marcus ML, Brody MJ: Participation of Parabrachial Nuclear Region in
Baroreflex Coronary Vasoconstriction. FASEB J., 3:A975, 1989.
17. De Boel SL, Gutterman DD: Is Coronary Vasoconstriction a Component of the Cerebral
Ischemic Response? Circulation, 80:II-552, 1989.
27
18. LaMaster TS, Paul RK, Gutterman DD: Coronary Constrictor Pathway From Anterior
Hypothalamus Projects Through Rostroventrolateral Medulla. Clin Res, 37:882A, 1989.
19. Gutterman DD, Ben-Haim S, Morgan DA: Brief Myocardial Ischemia Alters the Coronary
Vascular Response to Vagal Stimulation. FASEB J, 4:A402, 1990.
20. Paul RK, Gutterman DD, Brody MJ. Induction of Neurogenic coronary vasoconstriction from
spinal cord is asymmetrical. Circ 82: III-636, 1990.
21. Gutterman DD, Barber CE, Morgan DA. Effect of Neuropeptide Y on transmural distribution
of myocardial blood flow. Circ 82 (Suppl. III): III-336, 1990.
22. Law HI, Jones LF, Brody MJ, Gutterman DD. Differential regional vascular responses to
electrical and chemical activation in rostral ventrolateral medulla.
23. Cave A, Gutterman DD: Role of Cell Bodies in the Region of Parabrachial Nucleus in
Baroreflex Coronary Vasoconstriction. FASEB, 1991.
24. Nair BA, Paul RK, Murad Y, Gutterman DD, Brody MJ: Does the Area Postrema Mediate
Ouabain-Induced Coronary Vasoconstriction? FASEB J, 5:A1113, 1991.
25. McDermott DA, Mellen ST, Gebhart GF, Gutterman DD: Pericardial Administration of
Bradykinin (BK) to Rats Produces a Receptor-Mediated Reflex Change in Mean Arterial
Pressure. FASEB, 1991.
26. Cave AR, LaMaster TS, Gutterman DD: Coronary Constrictor Pathway from Anterior
Hypothalamus Includes Neurons in Rostroventrolateral Medulla. American Heart Association,
64th Scientific Sessions, 1991.
27. Gutterman DD, Morgan DA, Dellsperger KC: Differential Coronary Response to
Norepinephrine and Sympathetic Stimulation in Diabetic Dogs. American Heart Association,
64th Scientific Sessions. Circulation, 84:II-558, 1991.
28. Goodson AR, Liebold JM, Gutterman DD. Sustained coronary vasoconstriction during
electrical activation in anterior hypothalamus in rats.
29. Dellsperger KC, Brooks LA, Eastham CL, Gutterman DD: Coronary Microvascular
Vasodilator Responses in Diabetic Dogs. American Heart Association, 64th Scientific Sessions,
Circulation, 84:II-557, 1991.
30. McDermott DA, Meller ST, Gebhart GF, Gutterman DD: Characterization of the Reflex
Hemodynamic Response to Intrapericardial Bradykinin. FASEB J., 6:A1293, 1992.
31. Ben-Haim S, Kienzle M, Gutterman DD. Beat by beat ECG variability for detection of patients
with positive electrophysiologic study.
28
32. Ben-Haim SA, Becker B, Kaplinsky E, Gutterman DD, Palti Y. Prediction of immediate
ventricular fibrillation following by QRS variability coronary artery ligation in dogs. J Am Coll
Cardiol 20: 1270-1276, 1992.
33. Goodson AR, Leibold JM, Gutterman DD: Glibenclamide Produces Coronary Constriction in
Cat. FASEB J, 6:A1753, 1992.
34. Dellsperger KC, Brooks LA, Gutterman DD: Hyperglycemia Attenuates Coronary
Microvascular Dilation to Acetylcholine. FASEB J, 6(4):A1580, 1992.
35. Goodson AR, Leibold JM, Gutterman DD: Inhibition of Nitric Oxide Synthesis Augments
Centrally-Induced Sympathetic Coronary Vasoconstriction in Cats. Circulation 86(4):I-509,
1992.
36. Dellsperger KD, Brooks LA, Gutterman DD: Enhanced Coronary Microvascular Vasodilation
to an ATP-Sensitive Potassium Channel Opener in Diabetes. Circulation, 86(4):I-486, 1992.
37. Gutterman DD, Leibold JM, Morgan DA: Do Oxygen-Derived Free Radicals Contribute to
Neural Stunning in the Heart? Circulation, 86(4):I-689, 1992.
38. Dellsperger KC, Brooks LA, Gutterman DD. Enhanced coronary microvascular vasodilation to
an ATP-sensitive potassium channel opener in diabetes.
39. Dellsperger KC, Brooks LA, Morgan DA, Gutterman DD. Adenosine responses are not
impaired in the coronary circulation of diabetic dogs.
40. Pettersen MD, Morgan DA, Leibold JM, Ben-Haim S, Gutterman DD: Sustained Reduction in
Coronary Constriction to Sympathetic Stimulation Following Intracoronary Adenosine. FASEB
J., 7:A212, 1993.
41. Miller FJ, Dellsperger KC, Gutterman DD: Hyperglycemia Alters Endothelium Dependent
Relaxation of Coronary Microvessels but not Conduit Vessels In Vitro. FASEB J., 7:A423,
1993.
42. Dellsperger KC, Brooks LA, Gutterman DD: Hyperglycemia Results in Enhanced Coronary
Microvascular Responses to RP 52891. FASEB J., 7:A423, 1993.
43. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD. Acetylcholine constricts isolated
human coronary resistance vessels.
44. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD. Isolated human coronary arterioles
exhibit myogenic tone.
45. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD: Differential Effect of Acetylcholine on
Atrial and Ventricular Resistance Vessels Isolated from Human Hearts. JACC, 2/94:427A.
29
46. Oltman CL, Gutterman DD, Dellsperger KC. Glycoslated hemoglobin impairs coronary
microvascular responses to acetylcholine in vitro.
47. Ammar Jr RF, Gutterman DD, Dellsperger KC. Coronary microvascular responses to
metabolic stimulation in diabetes.
48. Miller FJ, Dellsperger KC, Oltman CL, Gutterman DD.: Alloxan-Induced Diabetes Mellitus
Impairs Endothelium Dependent Vasodilation of Canine Coronary Arterioles. Circulation, 90:I430, 1994.
49. Abe T, Morgan DA, Gutterman DD: Specific Role of Adenosine Receptors in Mediating PostIschemic Dysfunction of Coronary Sympathetic Innervation. Circulation 90:I-269, 1994.
50. Ammar Jr RF, Gutterman DD, Dellsperger KC: Topically Applied Superoxide Dismutase and
Catalase Normalize Coronary Arteriolar Responses to Acetylcholine in Diabetes Mellitus In
Vivo. Circulation, 90:I-574, 1994.
51. Ammar RF, Gutterman DD, Dellsperger KC: Effect of Superoxide Dismutase (SOD) on
Microvascular Acetylcholine (ACh) Responses in Diabetes. FASEB J., 8:A292, 1994.
52. Sundaram K, Liebold JM, Gutterman DD: Inhibition of NO Synthase Augments Sympathetic
Coronary Vasoconstriction to Stellate Stimulation in Cats. FASEB J., 8:A847, 1994.
53. Abe T, Morgan DA, Gutterman DD: Post-Ischemic Dysfunction of Sympathetic Coronary
Innervation Involves Adenosine Receptor Activation. FASEB J., 8:A848, 1994.
54. Rodriguez-Iglesias E, Miller FJ, Dellsperger KC, Gutterman DD: Role of Prostaglandins and
Nitric Oxide in the Human Atrial Coronary Arteriolar Response to Acetylcholine. FASEB J.,
10(4):A912, 1995.
55. Abe T, Morgan DA, Gutterman DD: Effects of Activating Selective Adenosine Receptors on
Sympathetic Coronary Innervation. FASEB J., 9(4):A840, 1995.
56. Paul RK, Breu M, Gutterman DD. Laterality of neurogenic coronary vasoconstriction in male
and female cats.
57. Abe T, Sengupta JN, Gebhart GF, Gutterman DD: Reduced Cardiac Sympathetic Afferent
Activity Following Brief Ischemia. Circ, 92:I-60, 1995.
58. Abe T, Morgan DA, Gutterman DD: Protection by Nerve Growth Factor Against Postischemic
Dysfunction of Sympathetic Coronary Innervation. Circ., 92:I-60, 1995.
59. Miller FJ, Dellsperger KC, Gutterman DD: Mechanism of Human Coronary Arteriolar
Relaxation to Adenosine Diphosphate. Circ., 92:I-131, 1995.
30
60. Miller FJ, Dellsperger KC, Gutterman DD: Basal Tone of Isolated Human Coronary Arterioles
Depends on Protein Kinase C Activation. Circ., 92:I-430, 1995.
61. Ammar Jr RF, Gutterman DD, Dellsperger KC. Mechanisms of impaired dilation of coronary
arterioles during increases in myocardial oxygen consumption in diabetes mellitus.
62. Miura H, Chappell DA, Gutterman DD: Preserved Dilation in Carotid Arteries of
Apolipoprotein (APO)E and APOE + LOL Receptor Deficient Mice. FASEB J., 10:A604, 1996
63. Scott E, Breu M, Gutterman DD: Coronary Arteriolar Response to Norepinephrine in Humans.
FASEB J, 10:A47, 1996.
64. Bocker J, Chappell DC, Gutterman DD: Selective Impairment of Endothelium Dependent
Vasodilation Following Responses to Oxidized Low Density Lipoprotein. FASEB J, 10:A604,
1996.
65. Oltman CL, Gutterman DD, Dellsperger KC. Role of superoxide in impaired endotheliumdependent vasodilation of coronary arterioles from diabetic dogs.
66. Miura H, McCoy DM, Gutterman DD: Human Coronary Arteriolar Relaxation to Arachidonic
Acid Depends upon Cytochrome P450 Monooxygenase. Circ., 94:I-63, 1996.
67. Miura H, Miller FJ, McCoy DM, Gutterman DD: Mechanism of Human Coronary Arteriolar
Relaxation to Bradykinin. Circ., 94:I-241, 1996.
68. Miller FJ, Gutterman DD, Davidson BL: Adenovirus Mediated Gene Transfer to Isolated
Canine and Human Coronary Conduit and Resistance Vessels. Circ., 94:I-243, 1996.
69. Miura H, Chappell DA, Gutterman DD: Mechanisms of Impaired Endothelium-Dependent
Vasodilation in Carotid Arteries of Apolipoprotein E and LDL Receptor-Deficient Mice. Circ.,
94:I-425, 1996.
70. Miller FJ, Dellsperger KC, Gutterman DD: Protein Kinase C Dependent Myogenic
Constriction of Isolated Human Coronary Arterioles. Circ., 94:I-489, 1996.
71. Oltman CL, Gutterman DD, Quinn KA, Bar RS, Dellsperger KC. Insulin and IGF-1 induced
vasodilation in canine coronary microvessels.
72. Miura H, Gutterman DD: Role of Ca2+-Activated Potassium Channels in Human Coronary
Arteriolar Relaxation to Bradykinin. FASEB J, 11:A44, 1997.
73. Murphy SL, Beasley K, Gutterman DD: Circulating Factor in Diabetic Serum Contributes to
Impaired Endothelial Dependent Dilation. FASEB J, 11:A157, 1997.
31
74. Miller Jr FJ, Gutterman DD, Heistad DD, Davidson BL. Gene transfer of superoxide dismutase
reduces superoxide anion but does not improve endothelial dependent relaxation in
atherosclerosis.
75. Miller Jr FJ, Mozena JD, Gutterman DD, Davidson BL. In Situ visualization of reactive
oxygen species in atherosclerosis.
76. Miura H, Breu M, Gutterman DD. Hypoxia induces human coronary arteriolar dilation via
ATP-sensitive potassium channel activation. Circ 96:I-74, 1997.
77. Miura H, Gutterman DD. Human coronary arteriolar dilation to bradykinin depends upon
hyperpolarization via Ca2+-activated potassium channel activation. Circ 96:I-16, 1997
78. Miura H, Breu M, Gutterman DD. Diabetes mellitus impairs ATP-sensitive potassium channel
function of human coronary arterioles. Circ 96:I-17, 1997.
79. Gutterman DD, Breu M. Flow-mediated vasodilation of human coronary arterioles does not
require nitric oxide synthase. Circ 96: I-310, 1997.
80. Manthei SA, Rupert BE, Gutterman DD. Thrombin induced vasodilation does not require
activation of pertussis toxin-sensitive g-proteins. Faseb J. 12:A670, 1998.
81. Miura H, Gutterman DD. Membrane hyperpolization and vasodilation of human coronary
arterioles to arachidonic acid (AA) via cytochrome P450 monooxygenase (P450). FASEB J.
82. Terata K, Miura H, Gutterman DD. Potent Vasodilation to Adrenomedullin in Isolated Human
Coronary Arterioles. Faseb J. 12: A405, 1998.
83. Miura H, Manthei SA, Gutterman DD. Flow-induced dilation depends upon membrane
hyperpolarization via Ca2+-activated K+ (KCa) channels in human coronary arterioles. Circ 98:I138, 1998.
84. Miller FJ, Mozena JE, Foresman EL, Davidson BL, Gutterman DD. Smooth muscle cell
production of superoxide is increased in atherosclerosis. Circ 98:I-311, 1998.
85. Terata K, Yorek MA, Gutterman DD. Acetylcholine-induced arteriolar dilation mediated by Kchannel is reduced in STZ-induced diabetic rats with motor nerve dysfunction. Circ 98:I-400,
1998.
86. Miller FJ, Mozena J, Foresman EL, Gutterman DD, Davidson BL. Superoxide production is
increased throughout the vascular wall of atherosclerotic mice aorta and mediated by a
membrane bound NADPH oxidase. Circ 98:I-733, 1998.
87. Terata K, Miller FJ, Gutterman DD. Effect of superoxide on K-channel mediated responses in
human coronary arterioles. Circ 98:I-825, 1998.
32
88. Oltman CL, Kern TS, Brooks LA, Kane NL, Gutterman DD, Dellsperger KC. Vascular
reactivity of coronary arterioles from 5 year diabetic dogs. Faseb J 13:A88, 1999.
89. Terata K, Liu Y, Gutterman DD. Minimal contribution of superoxide to myogenic constriction
of rat small coronary arteries. Circulation 100:I417-I418, 1999.
90. Liu Y, Terata K, Gutterman DD. Elevated glucose generates superoxide and reduces voltagedependent K=channel current in rat coronary artery vascular smooth muscle cells. Faseb J
14:A163, 2000.
91. Liu Y, Terata K, Nicolosi A, Gutterman DD. Peroxynitrite inhibits human coronary arteriolar
dilation to activation of Ca2+-activated K+ channels. Circulation 102:II-113, 2000.
92. Liu Y, Terata K, Gutterman DD. High glucose reduces voltage-dependent K+ current by
NADPH oxidase-generated superoxide. Circulation 102:II-255, 2000.
93. Terata K, Mirua H, Sato A, Liu Y, Gutterman DD. Minimal contribution of nitric oxide (NO)
and Katp channels to adenosine-induced dilation of coronary arterioles in patients with coronary
artery disease. Circulation 102:II-255, 2000.
94. Chai Q, Gutterman DD, Liu Y. Elevated Glucose Impairs cAMP Mediated Dilation by
Reducing Voltage-dependent K+ (Kv) Channel Activity in Coronary Vascular Smooth Muscle
Cells (VSMCs). FASEB Journal, V15, No. 5: A764, 2001.
95. Miura H, Sato A, Gutterman DD. K+-Induced Dilation Involves Both Na+/K+ ATPase and
Inwardly Rectifying K+ Channels (KIR) in Human Coronary Arterioles. FASEB Journal, V15,
No. 5: A765, 2001.
96. Sato A, Miura H, LiuY, Chai Q, Somberg LB, Eberhardt LM, Gutterman DD. Gender based
differences in endothelium dependent vasodilation of human arterioles. FASEB Journal, V15,
No. 5: A1122, 2001.
97. Liu Y, Chai Q, Gutterman DD. Peroxynitrite Inhibits Ca2+-Activated K+ Channel Activity in
Smooth Muscle of Human Coronary Arterioles. Circulation, V104, No. 17: II-31, 2001.
98. Miura H, Sato A, Saito T, Miura M, Gutterman DD. Evidence for Multiple EndotheliumDerived Hyperpolarizing Factors in Human Coronary Arterioles. Circulation, V104, No. 17: II39, 2001.
99. Miura H, Saito T, Miura M, Gutterman DD. Diazoxide Protects against Hypoxia/IschemiaInduced Injury in Human Coronary Arterioles in Vitro. Circulation, V104, No. 17: II-114, 2001.
100. Miura H, Qiang C, Liu Y, Saito T, Miura M, Gutterman DD. Flow-Mediated Dilation of
Human Coronary Arterioles Involves Production of Hydrogen Peroxide. Circulation, V104, No.
17: II-285-6, 2001.
33
101. Sato A, Miura H, Liu Y, Gutterman DD. Differential Regulation of the Human Coronary
Arterioles by Adenosine Receptor Subtypes. Circulation, V104, No. 17: II-287, 2001.
102. Sato A, Miura H, Liu Y, Nicolosi AC, Sakuma I, Gutterman DD. Involvement of Intermediate
Conductance Ca2+-Activated K+ Channels in Adenosine-Induced Human Coronary Arteriolar
Dilation. FASEB Journal, V16, No. 5: A860, 2002.
103. Li H, Gutterman DD, Liu Y. Elevated Glucose Impairs cAMP-mediated Voltage-dependent
K+ (Kv) Channel Activity in Coronary Vascular Smooth Muscle Cells (VSMCs). FASEB
Journal, V16, No. 5: A860, 2002.
104. Miura H, Sato A, Saito T, Miura M, Gutterman DD. Oxidative Stress Impairs ATP-Sensitive
Potassium Channel (KATP)-Mediated Dilation of Human Coronary Arterioles (HCA) in
Diabetes Mellitus (DM). FASEB J, V16, No. 5: A860, 2002.
105. Liu YP, Li H, Stadnicka A, Suzuki A, Kwok W, Bosnjak Z, Gutterman DD. Differential
Response of KATP Channels to Superoxide in Coronary and Cardiac Myocytes. Circulation,
V106, No. 19: II-35, 2002.
106. Sato A, Miura H, Liu Y, Nicolosi A, Gutterman DD. Reactive Oxygen Species Mediate
Vasodilation of Human Coronary Arterioles. Circulation, V106, No. 19: II-111, 2002.
107. Liu Y, Zhao H, Kalyanaraman B, Johnson D, Gutterman DD. Mitochondria, a Source for
Generating H2O2 Plays a Key Role in Flow-Mediated Dilation in Human Coronary Arterioles.
Circulation, V106, No. 19: II-171, 2002.
108. Sato A, Miura H, Liu Y, Downey FX, Gutterman DD. Oxidative Stress Enhances Human
Coronary Arteriolar Dilation to Adenosine. Circulation, V106, No. 19: II-277, 2002.
109. Liu Y, Li H, Stadnicka A, Suzuki A, Kwok W, Bosnjak Z, Gutterman DD. Differential
Response of KATP Channels to Superoxide in Coronary and Cardiac Myocytes. Circulation,
V106, No. 19: II-35, 2002.
110. Sato A, Miura H, Liu Y, Nicolosi A, Gutterman DD. Reactive Oxygen Species Mediate
Vasodilation of Human Coronary Arterioles. Circulation, V106, No. 19: II-111, 2002.
111. Liu Y, Zhao H, Li H, Kalyanaraman B, Johnson D, Gutterman DD. Mitochondria, a Source for
Generating H2O2, Plays a Key Role in Flow-Mediated Dilation in Human Coronary Arterioles.
Circulation, V106, No. 19: II-171, 2002.
112. Sato A, Miura H, Liu Y, Downey FX, Gutterman DD. Oxidative Stress Enhances Human
Coronary Arteriolar Dilation to Adenosine. Circulation, V106, No. 19: II-277, 2002.
113. Hatoum OA, Binion DG, Otterson MF, Gutterman DD. Microvascular dysfunction in
inflammatory bowel disease- IBD. FASEB Journal, V17, No. 4: A69, 2003.
34
114. Ou H, Ou Z, Jones DW, Ackerman AW, Hillery CA, Gutterman DD, Guice KS, Oldham KT,
Pritchard KA. 4F, An Apo A-I mimetic preserves acetylcholine-induced vasodilation of carotid
arterioles in sickle cell disease mice. FASEB J, V17, No. 4: A371, 2003.
115. Li H, Liu Y, Gutterman DD. High glucose causes tyrosine nitration of Kv1.2 and Kv1.5 in rat
coronary arterial vascular smooth muscles cells (VSMCs). FASEB J, V17, No. 4: A505, 2003.
116. Liu Y, Li H, Gutterman DD. Complex I and III of electron transport chains play a key role in
flow-mediated dilation in human coronary arterioles. FASEB J, V17, No. 4: A506, 2003.
117. Sato A, Miura H, Liu Y, Reuben C, Gutterman DD. Adenosine-induced vasodilation in
coronary arterioles from subjects with diabetes: Effect of reactive oxygen species. FASEB J,
V17, No. 4: A508, 2003.
118. Miura H, Saito T, Gutterman DD. Shear stress induces endothelial generation and release of
hydrogen peroxide (H2O2) in human coronary arterioles (HCA). FASEB J, V17, No. 4: A509,
2003.
119. Ou J, Ou Z, Jones DW, Weihrauch D, Ackerman AW, Gutterman DD, Guice AS, Oldham KT,
Pritchard KA. An Apo A-I mimetic peptide preserves vasodilation in hypercholesterolemic
mice. FASEB J, V17, No. 4: A513, 2003
120. Miura H, Sato A, Saito T, Abu-Hatoum O, Gutterman DD. Adenosine Acts as an EndotheliumDerived Hyperpolarizing Factor in Human Coronary Arteriolar Dilation to Adenosine 5’Diphosphate. Circulation, V108, No. 17: IV-99, 2003
121. Miura H, Saito T, Fujiwara Y, Sato A, Abu-Hatoum O, Gutterman DD. Upregulation of
Intermediate Conductance Calcium-Activated Potassium Channels is Associated with Altered
Human Coronary Arteriolar Reactivity. Circulation, V108, No. 17: IV-102, 2003
122. Sato A, Miura H, Abu-Hatoum O, Bosnjac JJ, Gutterman DD. Different Mechanisms of
Dilation to Extracellularly and Intracellularly Produced Hydrogen Peroxide in Human Coronary
Arterioles. Circulation, V108, No. 17: IV-102, 2003
123. Liu Y, Li H, Gutterman DD. Cytoskeletal Elements are Critical in Flow-Mediated Dilation in
Human Coronary Arterioles. Circulation, V108, No. 17: IV-227, 2003
124. Chen Y, Gao Y, Cook C, Raza A, Biller J, Gutterman DD, Medhora M, Jacobs ER. Activation
of eNOS in bovine pulmonary artery endothelial cells by VEGF and 20-HETE. FASEB J, V18,
No. 5: A1238, 2004.
125. Miura H, Gutterman DD. Interaction of Two Distinct Endothelium-Derived Hyperpolarizing
Factors in the Human Coronary Microcirculation. Circulation, V110, No. 17: III-181, 2004.
35
126. Hatoum OA, Binion DG, Miura H, Bosnjak JJ, Otterson MF, Telford G, Gutterman DD. Role
for hydrogen peroxide in Ach-induced dilation of human intestinal microvessels. FASEB J, Vol.
18, No. 4: A624, 2004.
127. Liu Y, Mass M, Newman DK, Newman PK, Gutterman DD. Nitric oxide plays a more
predominant role in flow-mediated dilation in coronary arteries of PECAM-1-knockout mice.
FASEB J, Vol. 18, No. 4: A269-270, 2004.
128. Liu Y, Gutterman DD. Cellular Origin of EDHF (H2O2) Released from Human Coronary
Arterioles in Response to Shear Stress. Circ, V110, No. 17: III-76, 2004.
129. Miura H, Toyama K, Hatoum OA, Gutterman DD. Adenosine Mediates Human Coronary
Arteriolar Dilation to Adenosine 5’-triphosphate (ATP). FASEB J, Vol. 19, No. 4: A688, 2005.
130. Larsen BT, Miura HM, Campbell WB, Falck JR, Gutterman DD. Epoxyeicosatrienoic acids
induce vasodilation of human coronary arterioles via an iberiotoxin-sensitive mechanism.
FASEB J, Vol. 19, No. 4: A727, 2005.
131. Liu Y, Bubolz AB, Newman PJ, Newman DK, Gutterman DD. Ebselen restores the
endothelium derived hyperpolarizing factor (EDHF) component of coronary flow-mediated
dilation in PECAM-1-knockout mice. FASEB J, Vol. 19, No. 5: A1259, 2005.
132. Hatoum OA, Binion DG, Miura H, Phillips S, Gutterman DD. Nitric oxide (NO) assessment in
control and chronically inflamed inflammatory bowel disease (IBD) submucosal intestinal
microvessels. FASEB J, Vol. 19, No. 5: A1265, 2005.
133. Phillips SA, Somberg LB, Otterson MF, Telford GL, Nicolosi AC, Gutterman DD. Effect of
Coronary Artery Disease (CAD) on Flow Induced Dilation in Human Visceral Adipose
Resistance Vessels. FASEB J, Vol. 19, No. 5: A1265, 2005.
134. Liu Y, Gutterman DD. Evidence for H2O2 as the EDHF Mediating Flow-Induced Dilation in
Human Coronary Arterioles. Circulation, Vol. 112, No. 17: II-216, 2005.
135. Liu Y, Bienengraeber M, Bubolz A, Gutterman DD. High Glucose Reduces Kv1.5 Channel
Activity by Disrupting Protein Translocation in Coronary Smooth Muscle Cells. Circulation,
Vol. 112, No. 17: II-216, 2005.
136. Larsen BT, Otterson MF, Miura H, Phillips SA, Selle RM, Gutterman DD, Hatoum OA.
Radiation impairs endothelium-dependent dilation of murine intestinal arterioles via reduction of
nitric oxide by reactive oxygen species. FASEB J, V20, No. 5: A1162, 2006.
137. Bubolz AH, Wu Q, Gutterman DD, Liu Y. Ebselen Reduces Kv1 Channel Nitration and
Restores Kv1 Channel Function in Diabetic Rat Coronary Arteries. FASEB J, V20, No. 4:
A284, 2006.
36
138. Hatoum OA, Binion DG, Miura H, Larsen BT, Selle RM, Kopelman D, Gutterman DD. The
complex role of hydrogen peroxide (H202) in acetylcholine-induced dilation of human mucosal
intestinal microvessels. FASEB J, V20, No. 4: A282-283, 2006.
139. Miura H, Toyama K, Hatoum OA, Saito T, Gutterman DD. Down-regulation of Intermediate
Conductance Calcium-activated Potassium Channel (IKCa) Inhibits Human Coronary Smooth
Muscle Cell (HSMC) Proliferation. FASEB J, V20, No. 5: A1176, 2006.
140. Phillips SA, Jacquelyn KP, Syed AQ, Syed AA, Pleuss JP, Jurva JW, Gutterman DD. Do low
fat and low carbohydrate diets show similar improvement in endothelial function? FASEB J,
V20, No. 5: A1392, 2006.
141. Larsen BT, Miura H, Campbell WB, Gutterman DD. NADPH Oxidase-Derived Reactive
Oxygen Species Reduce Cytochrome P450 Mediated Dilation of Human Coronary Arterioles.
Circulation, Vol. 114, No. 18: II-246, 2006.
142. Zhang D, Bubolz AH, Gutterman DD. Activation of TRPV4 Channels Dilates Human
Coronary Arterioles: Role of Ca2+ Influx and Mitochondrial Redox Signaling. Circulation, Vol.
114, No. 18: II-247, 2006.
143. Bubolz AH, Zhang X, Liu Y, Gutterman DD. Nitric Oxide Inhibits Flow-mediated Dilation in
Human Coronary Arterioles by Regulating Mitochondrial Production of Reactive Oxygen
Species. Circulation, Vol. 114, No. 18: II-20, 2006.
144. Toyama K, Hatoum OA, Gutterman DD, Miura H. Role of CD73, Ecto-5’ Nucleotidases, in
Human Coronary Arteriolar Dilation to Adenine Nucleotides. Circulation, Vol. 114, No. 18: II20, 2006.
145. Phillips SA, Somberg LB, Hatoum OA, Gutterman DD. Mechanisms of hydrogen peroxide
induced vasoconstriction in human adipose resistance arteries. FASEB J, V21, No. 5: A491,
2007.
146. Toyama K, Saito T, Fujiwara Y, Hatoum OA, Gutterman DD, Miura H. Intermediate
Conductance Calcium-activated Potassium Channel, KCa3.1, Plays an Important Role in
Macrophage (MO) Migration in Atherosclerosis. FASEB J, V21, No. 6: A854, 2007.
147. Zhang D, Bubolz AH, Gauthier KM, Campbell WB, Gutterman DD. TRPV4 channel-mediated
Ca2+ entry and vasodilatation in small bovine coronary arteries. FASEB J, V21, No. 6: A859,
2007.
148. Bubolz AH, Zhang DX, Larsen BT, Gutterman DD. TRPV4 mediates flow-induced dilation in
human coronary arterioles. FASEB J, V21, No. 6: A1234, 2007.
149. Phillips SA, Syed AQ, Syed AY, Das EK, Jurva JW, Gutterman DD. Resistance and aerobic
exercise protects against endothelial dysfunction induced by acute exertion. FASEB J, V21, No.
6: A935, 2007.
37
150. Larsen BT, Phillips SA, Bubolz AH, Zielonka J, Kalyanaraman B, Gutterman DD. HPLC
separation of hydroethidine products: a specific and sensitive method for quantifying
microvascular superoxide. FASEB J, 2007 21:5;577.2.
151. Wittenburg AL, Phillips SA, Gutterman DD. The role of catalase and endothelium in hydrogen
peroxide induced vasodilatation of human adipose arterioles. FASEB J, Late-Breaking, LB99:
2007.
152. Miura H, Toyama K, Fujiwara Y, Saito T, Hatoum OA, Gutterman DD. Intermediateconductance Calcium-activated Potassium Channel, KCa3.1, Plays an Important role in
Macrophage Migration in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology
Annual Conference, Chicago, IL, 2007.
153. Larsen BT, Bubolz AH, Pritchard Jr KA, Gutterman DD. Endothelial NADPH oxidase
mediates bradykinin-induced dilation of human coronary arterioles. 8th World Conference for
Microcirculation, Milwaukee, WI, 2007
154. Zhang D, Bubolz A, Mendoza S, Gutterman DD. TRPV4 channel mediates flow-induced
dilation in mouse small mesenteric arteries. FASEB J 2008 22:964.9
155. Wittenburg AL, Phillips S, Gutterman DD. Catalase inhibition effect on exogenous hydrogen
peroxide induced vasoconstriction in diseased human arterioles. FASEB J 2008 22:1148.15
156. Mendoza SA, Gutterman DD, Bubolz A, Suzuki M, Zhang DX. Role of TRPV4 channels in
agonist-induced endothelial Ca2+ entry and vasodilation: Evidence from TRPV4-deficient mice.
FASEB J. 2008 22:1181.4
157. Larsen BT, Campbell WB, Gutterman DD. 12- and 15-hydroxyeicosatetraenoic acids may
function as endothelium-derived hyperpolarizing factors in the human coronary microcirculation.
FASEB J. 2008 22:914.8
158. Das EK, Gutterman DD, Phillips SA. Exercise Protects Against Endothelial Dysfunction
During Oral Glucose and High Fat Load. FASEB J. 2008 22:1235.14
159. Migrino RQ, Bright M, Pajewski N, Truran S, Gutterman DD, Hari P. Abstract 2400: Late
Gadolinium Enhancement on MRI is a Prognostic Marker of Poor Survival in Light Chain
Amyloidosis: Results from Long-Term Follow Up. Circulation, Oct 2008; 118: S_718.
160. Migrino RQ, Hari P, Bright M, Phillips S, Truran S, Wittenburg A, Wang J, Gutterman DD.
Abstract 2401: Endothelial Dysfunction and Oxidative Stress in Human Coronary
Microvasculature Following Acute Exposure to AL Amyloid Light Chains: New Mechanism of
Amyloid Injury. Circulation, Oct 2008; 118: S_718 - S_719.
38
161. Wang J, Gutterman DD, Widlansky ME. Abstract 410: Mitochondrial Uncoupling with CCCP
Reverses Acute Hyperglycemia Induced Endothelial Dysfunction in Human Arterioles
Circulation, Oct 2008; 118: S_299.
162. Gutterman DD. 2008 George E. Brown Memorial Lecture—Flow-Induced Vasodilation in the
Human Heart: Unique Endothelial Mechanisms and Clinical Insights Circulation, Oct 2008; 118:
A_11.
163. Wittenburg AL, Mendoza SA, Zhang DX, Gutterman DD. Unmasking a role for nitric oxide in
acetylcholine-induced vasodilation in diseased human coronary arterioles. FASEB J. Apr 2009
23:LB73
164. Zinkevich NS, Wittenburg AL, Gutterman DD. Role of mitochondria in flow-induced dilation
of human adipose arterioles from subjects with and without coronary artery disease. FASEB J.
Apr 2009 23:1006.3
165. Larsen BT, Miura H, Campbell WB, Gutterman DD. 12- and 15-Hydroxyeicosatetraenoic
Acids (HETEs) Function as Endothelium-Derived Hyperpolarizing Factors (EDHFs) in Human
Coronary Arterioles. FASEB J. Apr 2009 23:952.17
166. Gutterman DD. Endothelial function and cardiovascular risk. Clinical Cardiology. Oct 2009
32:15
167. Larsen BT, Mendoza SA, Campbell WB, Gutterman DD. Lipoxygenases mediate endotheliumdependent vasodilation in the human coronary microcirculation. Experimental Biology,
Anaheim CA. Apr 2010
INVITED LECTURES/WORKSHOPS/PRESENTATIONS (must be invited to participate)
• Visiting Lecturer: Henry Ford Hospital, Cardiology Division. November, 1986
• Visiting Lecturer: Cardiology Division, SUNY, Buffalo, New York. February, 1987
• Central Regulation and Integration of Coronary Vasomotion. Henry Goldberg Symposium (IV).
Haifa, Israel. May, 1987
• Central Neural Control of Coronary Circulation. Symposium on Neural Control of the
Circulation, American College of Cardiology. March, 1990
• AHA Winter Conference. Snow Bird, Utah. January 29 - February 2, 1991
• Department of Physiology, Texas A&M University. October 31 - November 2, 1991
• Michael J. Brody Symposium. Iowa City, IA. December, 1991
• Use of Echocardiography in Evaluating Patients for Cardiac Source of Embolus. International
Conference on Cardiac Instrumentation. Nice, France. June, 1992
• Wyeth-Ayerst Research Awards Symposium. Princeton, NJ. June, 1992
• National AHA Symposium Public Affairs Issues and the AHA. August, 1992
39
• Medical Research and the AHA. Iowa City Optimist Club, Iowa City, IA. December, 1992
• Silent Myocardial Ischemia. 1993 Family Practice Refresher Course. Iowa City, IA. March,
1993
• Effect of Brief Ischemia on Neural Coronary Control. Bioengineering Seminar, Technion
Institute of Technology, Haifa, Israel. September, 1993
• Central Control of the Coronary Circulation. Melvin C. Marcus Symposium. Iowa City, IA.
October, 1993
• Diagnosis and Treatment of Silent Myocardial Ischemia. Akita University Lecture Series, Akita,
Japan. February, 1994
• Central Neural Control of the Coronary Circulation. 1st Department of Physiology, Kurume
Medical Center, Kurume, Japan. February, 1994
• Central Neural Control of the Coronary Circulation. University of Occupational &
Environmental Health, Kitakyushu, Japan. March, 1994
• Neural Control of Coronary Blood Flow. Tel Hashomer Department of Cardiovascular Diseases,
Sheba Medical Center, Israel. August, 1994
• Visiting Scientist: SUNY Buffalo Cardiology Division, Center for Cardiopulmonary Biology
Seminar Mechanisms of Neural Cardiac Stunning. February, 1996
• Physiological Control of Human Coronary Arterioles. AHA Scientific Sessions. November,
1996
• Control of Tone in Human Microvessels. Coronary Physiology and Cardiac Metabolism
Workshop, International Union of Physiological Sciences (IUPS) XXXIII Congress.
St. Petersburg, Russia. June-July, 1997
• Visiting Professor and Physiology Seminar Speaker. Department of Physiology, Medical
College of Wisconsin. January 21, 1998
• Keynote speaker: 3rd Tohoku Cardiac and Renal Conference. Sendai, Japan. June, 1998
• Ion Channels and Cardiovascular Regulation. Sapporo International Symposium. Hokkaido
University Faculty House, Sapporo, Japan. June 15, 1998
• Integrated Control of Pressure and Blood Flow in Coronary Microcirculation. International
Workshop Co-Chair: Pisa, Italy. June 2000
• Neural Cardiac Stunning – Basic Science and Clinical Implications. Anesthesiology Grand
Rounds, University of Chicago, Chicago, IL. August 30, 2000
• University of Alabama at Birmingham's 11th Annual Vascular Biology and Hypertension
Symposium. October 12-15, 2000
• Microvascular Function: EDHF vs. NO which is in Control? Symposium Chair and Presenter:
AHA Scientific Sessions. 2000
• Dudley Johnson Symposium. Medical College of Wisconsin. November 20, 2000
• Physiology Department Seminar. New York Medical College, Valhalla, NY. December 11,
2000
40
• Cardiology Grand Rounds. University of Louisville, Louisville, KY. February, 2001
• 5th Scientific Meeting for Pharmacotherapy of Cardiovascular Diseases. Tokyo, Japan. June,
2001
• Symposium on Cardiovascular Function. Akita, Japan, October 2, 2001
• Symposium on Cardiovascular Function. Beijing Friendship Hospital, Beijing, China. May,
2002
• Duke University Cardiology Grand Rounds. February, 2003
• University of North Carolina Cardiology Grand Rounds. March, 2003
• Keynote Speaker: 2nd International Symposium on EDHF. Tokyo, Japan. January, 2003
• UAB Vascular Biology and Hypertension Seminar. March, 2003
• 11th William Ganz Symposium Program – Vascular Biology Update. Akita, Japan. April, 2003
• University of Iowa Cardiovascular Distinguished Alumni Award Lecture. Iowa City, IA. June,
2003
• 25th Annual Meeting of the International Society for Heart Research (ISHR). Mystic, CT. June,
2003
• Boron Lecturer, UCLA Cardiology Division. October, 2003
• Medical College of Georgia, Department of Physiology. January, 2004
• Louisiana State University, Department of Physiology, Shreveport, LA. February, 2004
• Cardio-Kidney Investigators’ Meeting, Amelia Island, FL. May 2004.
• British Pharmacology Society Annual Meeting, Bath, England. July, 2004
• Understanding Blood Vessels. Symposium Chair: XVIII World Congress, International Society
for Heart Research, Brisbane, Australia. August, 2004
• Cardio-Kidney Investigators Meeting, Amelia Island, FL. May, 2005
• EDHF and Nitric Oxide interactions in the circulation. Cardiovascular Seminar: AHA Scientific
Meeting, Dallas TX. 2005
• Novel mechanisms regulating the Coronary Circulation. Cardiovascular Seminar: AHA
Scientific Meeting, Dallas TX. 2005
• How are Evidence-Based Guidelines Developed? The ACCP Health and Science Policy
Committee Step-by-Step Process. Plenary Session, CHEST, Montreal, Quebec, Canada. 2005
• Novel mechanism of flow-induced vasodilation in the human coronary microcirculation.
University of Wisconsin Cardiovascular Center, Madison, WI. March, 2006.
• Mechanisms of flow-induced dilation in the human coronary vasculature. AHA BCVS Summer
Conference, Keystone, CO. July, 2006
• EDHF in the coronary circulation. Medical Physics Meeting, Amsterdam. February, 2007
• Canadian Thoracic Society Conference on COPD Guideline Development. April, 2007
41
• Clinical Guidelines – an important tool for Quality Assurance in Modern Day Medicine.
Transpacific Asia Medical Summit, Beijing, China. May, 2007
• Role of ROS in mediating flow-induced dilation. XIX World Congress of the ISHR, Bologna,
Italy. June, 2007
• Endothelial Function and Cardiovascular Health. American Council of Life Insurers. June, 2007
• Participation of ROS in flow-induced vasodilation. World Microcirculation Conference,
Milwaukee, WI. August, 2007
• Flow-mediated vasodilation in the human heart: Novel role of ROS. Department of Integrative
Physiology Colloquium, University of Nebraska. October, 2007
• Hydrogen peroxide as an endothelium derived hyperpolarizing factor. American Society of
Nephrology Advances in Research Conference. November, 2007
• Silent Myocardial Ischemia: Flow-induced vasodilation in the human heart. Japanese Society
for Circulatory Medicine, Sendai, Japan. February, 2008
• Endothelial function and cardiovascular health. Regina Estenes Memorial Lecture in Medical
Physiology, UMDNH-Robert Wood Johnson Medical School, Piscataway, NJ. March, 2008
• Flow-induced vasodilation in the human heart. Leonard Leight Distinguished Lectureship,
University of Louisville, Louisville, KY. April, 2008
• UCLA Distinguished Cardiovascular Lectureship, Los Angeles, CA. April, 2008
• Flow-induced vasodilation in the human heart. Endothelial function and dysfunction: insights
into cardiovascular risk. University of Toronto, Ontario. May 26-27, 2008
• Flow-induced vasodilation in the human heart. Endothelial function and dysfunction: insights
into cardiovascular risk. University of Pennsylvania Scientist Seminar, Philadelphia, PA. May
29-30, 2008
• Flow-induced vasodilation in the human heart: unique endothelial mechanisms and clinical
insights. George E Brown Memorial Lecture, AHA Scientific Sessions, New Orleans, LA. Nov
8-12, 2008
• Use of evidence-based guidelines as a means of improving cardiovascular health care. Plenary
Session, RCMI International Symposium on Health Disparities, University of Hawaii, Honolulu,
HI. Dec 1-4, 2008
• Human Microvascular Function in Disease: Mechanistic Insights. Keystone Symposium
Vancouver, BC (Canada). Feb 26 - Mar 1, 2009
• Regulation of the Human Coronary Microvasculature: Focus on Shear Stress-Induced Dilation.
University of Chicago, Chicago, IL. April, 2009
• Function and dysfunction of ion channels in the human coronary circulation. Experimental
Biology, New Orleans, LA. April, 2009
• Diagnosing Cardiovascular disease and complex OSA. European Respiratory Society, Vienna,
Austria. September, 2009
• Cardiomyopathy and cardiac arrhythmias. European Respiratory Society, Vienna, Austria.
September, 2009
42
• Endothelial Dysfunction. Great Wall International Congress of Cardiology, Beijing, China.
October, 2009
• Silent Ischemia. Great Wall International Congress of Cardiology, Beijing, China. October,
2009
• Cardiovascular Diseases and Complex Obstructive Sleep. ACCP CHEST, San Diego, CA.
November 2009
• Mechanisms of microvascular control. Translating Coronary Physiology and Biophysics to
Clinical Applications. Symposium on the occasion of the retirement of Professor Jos A.E. Spaan.
Amsterdam. February 2010
wes testing
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