Doctor of Philosophy Program
Doctor of Philosophy Program in Medical Sciences
(International Program)
(2011)
1. Name of Program
Doctor of Philosophy Program in Medical Sciences
2. Degree Title
Doctor of Philosophy
Ph.D.
3. Field of Study appearing on Transcript
FIELD OF STUDY Medical Sciences
4. Type of Program
Managerial Aspect
 Regular Program
 International Program
 English Program
Financial Aspect
 Regular Program
 Special Program
: Anatomy or
: Anatomical Pathology or
: Biochemistry or
: Forensic Sciences or
: Cell Biology and Human Molecular Genetics or
: Neuroscience or
: Parasitology or
: Pathology or
: Pharmacology or
: Physiology or
: Stem Cell and Regenerative Medicine
2
5. Responsible Departments
Department of Anatomy
Department of Biochemistry
Department of Physiology
Department of Parasitology
Department Of Pharmacology
Department of Pathology
Faculty of Medicine, Chulalongkorn University
6. Cooperation with other sections
6.1 This program cooperates with other sections within Chulalongkorn University including:
All departments of the Faculty of Medicine:
- Getting involve in teaching coursework
- Sharing laboratory
- Being a member of thesis committee
6.2 This Program cooperates with other sections outside Chulalongkorn University including:
1) Thai Red Cross Society:
Providing practical laboratory supports.
2) Foreign Organizations including Jichi Medical University, Yale University, NIH, and
Pennsylvania State University
Coordinating between Professors who have the same field of research interest from and
allowing students to conduct research at the other university.
7. Rationale
At the present time, all branches of Medical Sciences are rapidly developed. The integration of all
branches of medical sciences and the potential of professors in both basic and clinical medical sciences will
enable translational research, which will provide many advantages for diagnosis, treatment as well as the study of
pathology of diseases.
3
Doctor of Philosophy Program in Medical Sciences, Faculty of Medicine, Chulalongkorn
University, has been available since the second semester, academic year 2009. The program consists of nine
concentrations: Anatomy, Anatomical Pathology, Biochemistry, Molecular Biology and Genetics, Neuroscience
or Parasitology, Pathology, Pharmacology, Physiology. There are 4 structures for this program: Scheme 1.1,
Scheme 1.2, Scheme 2.1, and Scheme 2.2.
In order to fulfill the faculty’s vision to become the world class medical school and to become a major
choice for international students, Faculty of Medicine, Chulalongkorn University, decided to establish Master of
Science Program in Medical Science (International Program), a research based program, structure Scheme 1.1
and Scheme 1.2.
8. Program’s Philosophy, Program’s Objectives, Pleasant Characteristics of Graduates, and Graduates’ needs
8.1 Program’s Philosophy
This program is an integration of medical sciences, which proposes to produce academicians and
researchers for our society and to be widely accepted nationally and internationally.
8.2 Program’s Objective
1) To produce competent graduates who are proficient in modern sciences, have experiences in medical
research as well as have medical ethics.
2) To produce innovative research works in different branches of medical sciences including Anatomy,
Biohemistry, Parasitology, Physiology, Molecular Genetics, Neurology, Pathology , Anatomical
Pathology , and Pharmacology.
8.3 Outcome Characteristics of Graduates
8.3.1 Academic Excellence
8.3.2 Enthusiasm, Creativity, and Good Vision
8.3.3 Ability to synthesize and analyze problems
8.3.4 In Discipline
8.3.5 Morality and Ethic
8.3.6 Excellent Professional Skill, Good Communication Skills, Pleasant Personality
8.3.7 Self and Social Responsibility
9. This new program similar to other existing programs in Chulalongkorn University:
4
None
10. This kind of program is available in other universities aboard:
None
11. This program needs cooperation from foreign universities?
 No
 Yes Types of Cooperation  Collaborative Degree Program  Double Degree Program
12. Foreign university programs that are used in developing this program:
None
13. Implementation Date
First Semester, Academic Year 2010
14. Entry Requirement
14.1 For applicants who graduated Master Degree (Scheme 1.1)
14.1.1 Graduated Master of Science or equivalence
14.1.2 Other qualification in each year of graduate division’s announcement or program committee or
program committee approves the admission
14.2 For applicants who graduated Bachelor Degree (Scheme 1.2)
14.2.1 Graduated Bachelor of Science or equivalence
14.2.2 Other qualification in each year of graduate division’s announcement or program committee or
program committee approves the admission
15. Selection of Candidates
Refer to application manual of Graduate School, Chulalongkorn University, which will be announced every year.
16. Education System
5
The bi-semester academic year is divided into two semesters: First Semester (15 Weeks) and Second
Semester (Weeks). There may also be an additional summer session (6-8 Weeks) after the conclusion of the
second semester.
17. Duration
Not more than 6 years
18. Registration
 Maximum 15 credits for each semester
 For summer session, maximum 6 credits
19. Evaluation and Graduation
19.1 Evaluation
Evaluation of non-credit course will be assessed by the following letter:
“S” (Satisfactory)
“U” (Unsatisfactory)
Evaluation of Thesis will be assessed by the following criteria:
1. Very Good
2. Good
3. Pass
4. Fail
19.2 Thesis
The thesis or a part of thesis must be published or accepted for publication in two academic journals (one
of them must be an international journal.)
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20. Full-time staff of the Program
No
1
Name
Assoc. Prof. Dr. Vilai Chentanez, M.D.
2
Assoc. Prof. Dr. Padet Siriyasatien, M.D.
3
Assoc.Prof. Dr.Poonlarp Cheepsunthorn
4
Assoc Prof. Dr. Wilai Anomasiri
5
Assist. Prof. Dr. Nipan Israsena, M.D.
Degree
B.Sc. Honours (Chulalongkorn University)
M.D. Honours (Chulalongkorn University)
Ph.D. (Anatomy) (Mahidol Univeristy)
B.Sc. (Kasetsart University)
M.D. (Chulalongkorn University)
D.T.M. & H (Mahidol University)
Ph.D. (Molecular Entomology) Liverpool U.
B.Sc. (Zoology) (Kasetsart University)
M.Sc. (Medical Sciences) (Chulalongkorn
University)
Ph.D (Neuroscience) (Penn State, U.)
B.Sc.(Chulalongkorn University)
M.Sc. (Biochemistry) (Mahidol Univeristy)
Ph.D. (Biochemmistry) (U. of Alberta)
M.D. (Chulalongkorn University)
Ph.D.(Neuropharmacology) (Albert Einstein
College of Medicine New York)
21.1 Curriculum
21.1 Total Credits
21.1.1 For students who graduated Master Degree
Scheme 1.1
48 credits
7
21.1.2 For students who graduated Bachelor Degree
Scheme 1.2
72 credits
21.2 Structure of Program of Study
Scheme 1.1
Total Credits
Coursework Credits
Thesis Credits
Scheme 1.2
48
72
-
-
48
72
Note: All students must register to the course 3000894 (Doctor Dissertation Seminar) for every semester
with no credit and assessed by “S/U”
21.3 Course
3000828
Dissertation (Scheme1.1)
48
Credits
3000830
Dissertation (Scheme 1.2)
72
Credits
21.4 Study Plan
Scheme 1.1: For students who graduated Master Degree
First Year, First Semester
3000894
3000828
Doctoral Dissertation Seminar
Dissertation
Total
First Year, Second Semester
Credits
8
8
8
Credits
3000894
3000828
Doctoral Dissertation Seminar
Dissertation
Total
8
8
Second Year, First Semester
3000894
3000828
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Second Year, Second Semester
3000894
3000828
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Third Year, First Semester
3000894
3000828
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Third Year, Second Semester
3000894
3000828
Doctoral Dissertation Seminar
Dissertation
Total
Scheme 1.2: For students who graduated Bachelor Degree
Credits
8
8
9
First Year, First Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
First Year, Second Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Second Year, First Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Second Year, Second Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
Third Year, First Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Third Year, Second Semester
Credits
8
8
10
3000894
3000830
Credits
Doctoral Dissertation Seminar
Dissertation
Total
8
8
Fourth Year, First Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Fourth Year, Second Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
8
8
Fifth Year, First Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
4
4
Fifth Year, Second Semester
3000894
3000830
Doctoral Dissertation Seminar
Dissertation
Total
Credits
4
4
11
21.5 COURSE DESCRIPTION
3000828
DISSERTATION
3000830
DISSERTATION
3000894
DOCTORAL DISSERTATION SEMINAR
DOC DISSERT SEM
Appendix
48
72
-
12
Assoc. Prof. Dr. Vilai Chentanez, M.D.
Degree:
B.Sc. Honours (Chulalongkorn University)
M.D. Honours (Chulalongkorn University)
Ph.D. (Anatomy) (Mahidol Univeristy)
Publication:
1.
Chentanez V, Thanomsridejchai N, Duangmardphon N, Agthong S, Kaewema A, Huanmanop T, Maneesri
S. Ganglionside GM1 (porcine) ameliorates paclitaxel-induced neuropathy in rats. J Med Assoc Thai. 2009
Jan;92 : 50-7.
2.
Doklamyai P, Agthong S, Chentanz V, Huamanop T, Amarase C, Surunchupakorn P, Yotnuengnit P.
Anatomy of the lateral femoral cutaneous nerve related to inguinal ligament, adjacent bony landmarks, and
femoral artery. Clin Anat. 2008 Nov;21 (8):769-74.
13
3.
Agthong S. Chentanez V, Koonam J, Kaewsema A. Comparable morphometric date of pathological
nerve obtained using the three-window sampling method and total fiber quantification. Microsc Res Tech.
2008 Aug;71(8):585-7.
4.
Agthong S, Huanmanop T, Sasivongsbhakdi T, Ruenkhwan K, Piyawacharapun A, Chentanez V. Anatomy
of the superficial peroneal nerve related to the harvesting for nerve graft.
Surg Radiol Anat. 2008 Mar;30(2):145-8. Epub 2008 Jan 9.
5.
Huanmanop T, Agthong S, Luengchawapong K, Sasiwongpakdee T, Burapasomboon P, Chentanez V.
Anatomic characteristics and surgical implications of the superficial radial nerve.
J Med Assoc Thai. 2007 Jul;90(7):1423-9.
6.
Huanmanop T. Agthong S, Chentanez V, Surgical anatomy of fissures and foramina in the orbits of Thai
adults. J Med Assoc Thai. 2007 Nov;90(11):2383-91.
7.
Agthong S, Kaewsema A, Tanomsridejchai N, Chentanez V. Activation of MAPK ERK in peripheral
nerve after injury. BMC Neurosci. 2006 Jun 8;7:45.
8.
Chentanez V, Cha-Oumphol P, Kaewsema A, Agthong S, Huanmanop T. Morphometric data of normal
sural nerve in Thai adults. J Med Assoc Thai. 2006 May; 89(5): 670-4.
9.
Chentanez V, Cha-Oumphol P, Kaewsma A, Agthong S, Huanmanop T. Accuracy of the three-window
sampling method in morphometric analysis of human sural nerve. J Neurosci Methods. 2006
Oct;57(1):154-7
10. Aghtong S, Huanmanop T, Chentanez V. Anatomical variations of the supraorbital , infraorbital and
mental foraminal related to gender and side. J Oral Maxillofac Surg. 2005 Jun; 63(6): 800-4.
11. Chentanez V, Sanguanrungsinigul S, panyasawad N. Effects of Ganglioside on Paclitaxel (Taxol) Induced
Neuropathy in Rats. J Med Assoc Thai 2003 May; 86(5);449-456
14
Assoc. Prof. Dr. Padet Siriyasatien, M.D.
Degree:
B.Sc. (Kasetsart University)
M.D. (Chulalongkorn University)
D.T.M. & H (Mahidol University)
Ph.D. (Molecular Entomology) Liverpool U.
Publication:
1.
Thavara U, Tawatsin A, Bhakdeenuan P, Wongsinkongman P, Boonruad T, Bansiddhi J, Chavalittumrong
P, Komalamisra N, Siriyasatien P, Mulla M S. Repellent activity of essential oils against cockroaches
(Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand. Southeast Asian Journal of Tropical
Medicine and Public Health 2007;38 (4), pp. 663-673.
2.
Tawatsin A, Thavara U, Bhakdeenuan P, Chompoosri J, Siriyasatien P, Asavadachanukorn P, Mulla M S.
Field evaluation of novaluron, a chitin synthesis inhibitor larvicide, against mosquito larvae in polluted
15
water in urban areas
2007; 38(3):434-441.
3.
of
Bangkok, Thailand. Southeast Asian J Trop Med Public Health
Jariyapan N, Choochote W, Jitpakdi A, Harnnoi T, Siriyasatein P, Wilkinson MC, Junkum A, Bates PA.
Salivary gland proteins of the human malaria vector, Anopheles dirus B (Diptera: Culicidae). Rev Inst
Med Trop Sao Paulo. 2007 Jan-Feb;49(1):5-10.
1. Jariyapan N., Choochote W., Jitpakdi A., Harnnoi A., Siriyastien P., Wilkinson M.C. and Bates
P.A. A glycine- and glutamate-rich protein is female salivary gland-specific and abundant in the
malaria vector Anopheles dirus B (Diptera: Culicidae). J Med Entomol. 2006 Sep;43(5):867-74.
5.
Thavara U, Siriyasatien P, Tawatsin A, Asavadachanukorn P, Anantapreecha S, Wongwanich R, Mulla M
S. Double infection of heteroserotype of dengue viruses in field populations of Aedes aegypti and Aedes
albopictus (Diptera: Culicidae) and serological features of dengue viruses found in patients in Southern
Thailand. Southeast Asian J Trop Med Public Health 2006; 37(3):468-476.
6.
Kraivichian K, Nuchprayoon S, Siriyasatien P, Saksirisampant W, Nuchprayoon I. Resolution of
Eosinophilia after Treatment of Cutaneous Gnathostomiasis. J Med Assoc Thai 2005;88(Suppl 4): S163S166
7.
Siriyasatien P., Tangthongchaiwiriya K.., Kraivichian K., Nuchprayoon S., Tawatsin A., and Thavara U.
Decrease of mosquito salivary gland proteins after a blood meal: An implication for pathogenesis of
mosquito bite allergy. J Med Assoc Thai 2005;88(Suppl 4): S255-S259
8.
Siriyasatien P., Tangthongchaiwiriya K., Jariyapan K., Kaewsaitiam S., Poovorawan Y and Thavara U.
Analysis of salivary gland protein of the mosquito Armigeres subalbatus. Southeast Asian J Trop Med
Public Health 2005; 36(1):64-67
16
9.
Taksinvarajarn
R,
Tanayapong
P, Pongratanaman S, Hansasuta P, Bhattarakosol P,
Siriyasatien P. Prevalence of dengue virus in Aedes mosquitoes during dry season by semi-nested reverse
transcriptase-polymerase chain reaction (Semi-nested RT-PCR). J Med Assoc Thai 2004; 87 (Suppl.2):
S129-134
Assoc.Prof. Dr.Poonlarp Cheepsunthorn
Degree:
B.Sc. (Zoology) (Kasetsart University)
M.Sc. (Medical Sciences) (Chulalongkorn University)
Ph.D (Neuroscience) (Penn State, U.)
Publication:
1.
Kaomongkolgit R, Cheepsunthorn P, Pavasant P, Sanchavanakit N. (2008) Iron increases MMP-9
expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous
carcinoma cells. Oral Oncol. 44(6):587-94.
2.
Sangsanoh P, Waleetorncheepsawat S, Suwantong O, Wutticharoenmongkol P,
Weeranantanapan O, Chuenjitbuntaworn B, Cheepsunthorn P, Pavasant P, Supaphol P. (2007)
In vitro biocompatibility of schwann cells on surfaces of biocompatible polymeric electrospun fibrous and
solution-cast film scaffolds. Biomacromolecules. 8(5):1587-94.
17
3.
Suwantong O, Waleetorncheepsawat S, Sanchavanakit N, Pavasant P, Cheepsunthorn P, Bunaprasert T,
Supaphol P. (2007) In vitro biocompatibility of electrospun poly(3-hydroxybutyrate) andpoly(3hydroxybutyrate-co-3-hydroxyvalerate) fiber mats.Int J Biol Macromol. 40(3): 217-23.
4.
Cheepsunthorn P, Mairaue N, Nasee K. (2006) Estrogen enhances the inhibitory effect of iron on
microglial nitric oxide production.J Med Assoc Thai. 89(6):840-5.
5.
Cheepsunthorn P, Radov L, Menzies S, Reid J, Connor JR. (2001) Characterization of a novel brainderived microglial cell line isolated from neonatal rat brain. Glia. 35(1):53-62.
6.
Cheepsunthorn P, Palmer C, Menzies S, Roberts RL, Connor JR. (2001) Hypoxic/ ischemic insult alters
ferritin expression and myelination in neonatal rat brains. J Comp Neurol. 431(4):382-96.
7.
Chentanez V, Chittmittrapap S, Cheepsoonthorn P, Agthong S. (2000) New classification of
histochemical staining patterns of acetylcholinesterase activity in rectal suction biopsy in
Hirschsprung's disease. J Med Assoc Thai. 83(10):1196-201.
18
Assoc Prof. Dr. Wilai Anomasiri
Degree:
B.Sc.(Chulalongkorn University)
M.Sc. (Biochemistry) (Mahidol Univeristy)
Ph.D. (Biochemistry) (U. of Alberta)
Publication:
1.
Anomasiri W. and Tongtawee B. “Effects of Cardiac Rehabilitation on Fibrinolysis in Patients with
Coronary Artery Disease“. J Med Assoc Thai 2005; 88 (suppl 4):S242-8.
2.
Anomasiri W, Sanguanrungsirikul S, and Saichandee P. “Low dose creatine supplementation enhances
sprint phase of 400 meters swimming performance”. J Med Assoc Thai 2004; 87 (Suppl 2): S228 – S232.
19
3.
Anomasiri W, Sanguanrungsirikul S, Srikiatkachon A, and Chuntavan P. “Changes of
immune system in military recruits after the training program”. J Med Assoc Thai 2002; 85 (suppl 1): S327
–S335.
Assist. Prof. Dr. Nipan Israsena, M.D.
Degree:
M.D. (Chulalongkorn University)
Ph.D.(Neuropharmacology) (Albert Einstein College of Medicine New York)
Publication:
1.
Laothamatas J, Wacharapluesadee S, Lumlertdacha B, Ampawong S, Tepsumethanon V, Shuangshoti S
, Phumesin P, Asavaphatiboon S , Worapruekjaru L , Avihingsanon Y, Israsena N, Lafon M , Wilde H,
Hemachudha T.(2008) Furious and paralytic rabies of canine origin: Neuroimaging with virological and
cytokine studies. J Neurovirol; 14(2):119-129
2.
Israsena N, Kessler JA (2002) Msx2 and p21(CIP1/WAF1) mediate the proapoptotic effects of bone
morphogenetic protein-4 on ventricular zone progenitor cells. J Neurosci Res;69(6):803-9.
20
3.
Kan L, Israsena N, Zhang Z, Hu M, Zhao LR, Jalali A, Sahni V, Kessler JA (2004) Sox1 acts through
multiple independent pathways to promote neurogenesis. Dev Biol. 2004 ;269(2):580-94
4.
Israsena N, Hu M, Fu W, Kan L, Kessler JA (2004) The presence of FGF2 signaling determines whether
beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells Dev
Biol;268(1):220-31.