THYROID 2011
helen.christian@dpag.ox.ac.uk
Central and Pituitary regulation of the thyroid and feedback by T3 and T4
Boelen et al (2008) Fasting induced changes in HPT axis. Thyroid, 18(2): 123-129
Thorough review of the evidence for resetting of HPT axis regulation in caloric deprivation
Chiamolera & Wondisford (2009) Minireview: TRH and the thyroid hormone feedback mechanism.
Endocrinology 150:1091-1096
Fekete (2007) Negative feedback regulation of TRH neurons, role of neuronal afferents and Type 2
Deiodinase. Frontiers Neuroendocrinology 28:97-114
A thorough review of regulation of the TRH neuron – more than you need but an invaluable source of
information.
Mihaly et al (2000) J Clin Endocrinol Metab 85:2596-2603 TRH neurons innervated by NPY, AGRP
Human brain study showing innervation of TRH neurons by neurons involved in feeding
Postiglione et al (2002) TSH receptor role in thyroid gland development. PNAS 99:15462-15467
Thyroid hormone control of thermogenesis
Silva, JE (2006) Thermogenic mechanisms and their hormonal regulation. Physiol Rev 435-464
Very good review of thyroid and other hormonal control of thermogenesis, good starting point
Transgenic mouse studies that explore role of thyroid axis in control of BMR/thermogenesis
Abel et al (1999) J Clin Invest 103:271-279. Knockout of TR in pituitary
Shibusawa et al (2003) Thyroid hormone action in the absence of DNA binding. J Clin Invest 112:588.
Dupre S et al (2004) Endocrinology 145:2337-2345 Both thyroid hormone receptor isoforms reg TRH
Rescue of specific TRbeta isoforms in TRbeta KO mice shows both regulate TRH
Nikrodhanond et al (2006) Dominant role of TRH in the HPT axis. J Biol Chem 281:5000-5007
Compares TRH KO, TRbeta KO and double TR KO
Galton VA et al (2007) Thyroid hormone homeostasis in Deiodinase 2 KO. Endocrinology 148: 3080-8
Trajkovic et al (2007) Abnormal thyroid metabolism in MCR8 KO mice. J Clin Invest. 117:627-35;
Trajkovic-Arsic et al (2010) Endocrinology 151:5053-5062
Brown et al (2000) J Clin Invest 106:73-79 RXR deficiency gives thyroid hormone resistance
Golozoubova et al (2004) Depressed thermogenesis in mice devoid of all hormone-binding TH receptors.
Mol Endocrinol 18:384-401
Marrif H et al (2005) Temperature homeostasis in transgenic mice lacking TRalpha gene. Endocrinology
146:2872-2884
Gong et al (2000) Lack of obesity and normal response to fasting and thyroid hormone in mice lacking
uncoupling protein 3. J Biol Chem 275:16251-16257
De Jesus LQ et al (2001) The type 2 deiodinase is essential for adaptive thermogenesis in brown adipose
tissue. J Clin Invest 108:1379-1385
Non-genomic, rapid actions of thyroid hormones
Incerpi (2005) Thyroid hormones: rapid reply by surface delivery only. Endocrinology 146:2861-2863
(Commentary on article Bergh et al Endocrinology 146:2864)
Membrane transporter proteins: Thyroid hormone transport by MCT8
** Friesema et al (2006) Mutations in MCT8 thyroid transporter and disease. Nature Clin Practice 2:512523 or slightly more recent Visser WE et al (2007)Thyroid hormone transport in and out of cells. Trends
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Endocrin Metabolism 19:50-56
This group have written many reviews of their discovery of MCT8 and thyroid hormone transport, any are
good reads
Circadian rhythms
Ono et al (2008) Involvement of thyrotropin (TSH) in photoperiodic signal transduction in mice. PNAS
105:18238-18242
Appetite/obesity
Kong et al (2004) Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus
independent of changes in energy expenditure endocrinology 145: 5252-5258
Reinehr (2010) Obesity and thyroid function. Mol Cell Endocrinol 316: 165-71
Reproduction
Trokoudes et al (2006) Infertility and thyroid disorders. Current Opin Obstetrics and Gynecology 18:446
Thyroid receptors
Zhang et al (2000) Annu Rev Physiol 62:439-466 Mechanism of action of thyroid hormones. Review
Liu & Brent (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation.
Trends Endocrinol Metab 21:166-7
Fliers & Boelen (2010) Type 2 deiodinase and brown fat: the heat is on-or off. Endocrinology 15:4087-89
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