Sources of Variation – Mutation and Migration
I. Outline
a. Variation from Mutation
b. Variation from Recombination
c. Variation from Migration
II. Variation from Mutation
a. Role of Mutations in Variation
b. Mutation Rates
c. Change in allele frequencies due to mutation
d. Mutation/Selection Balance
III. Variation from Recombination
a. Impact of recombination on variation
b. Linkage equilibrium
c. Linkage disequilibrium
IV. Variation from Migration
a. Migration Rates
b. Changes in Allele Frequencies
V. TAP:
Chapter 17- #6, 8, 11c, 19
In a donor population, the allele frequencies for the normal (HA) and
sickle cell alleles (HS) are 0.9 and 0.1, respectively. A group of 550
individuals migrates to a new population containing 10,000 individuals;
in the recipient population, the allele frequencies are HA=0.99 and
HS=0.01.
A. Calculate the allele frequencies in the conglomerate population
(following migration).
B. Assuming that the donor and recipient populations are each in
Hardy-Weinberg Equilibrium, calculate the genotype
frequencies in the conglomerate population prior to further
mating between the donor and recipient populations.
C. What will be the genotype frequencies of the conglomerate
population in the next generation, assuming that it achieves
Hardy-Weinberg Equilibrium in one generation?