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Feng-Shiun Shie, Ph.D.
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Assistant Investigator
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Division of Mental Health And Substance Abuse Research
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E-mail: fshie@nhri.org.tw
Education
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Ph.D., University of Washington, Seattle, WA, U.S.A.,2000
M.S., Florida International University, Miami, FL, U.S.A.,1995
B.S., Fu-Jen University, Taipei, Taiwan,1988
Professional Experiences
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2000-2005 Senior Fellow/Acting Instructor, Division of Neuropathology,
Department of Pathology, University of Washington School of Medicine,
Seattle, Washington.
2005-present Assistant Investigator, Division of Mental Health and Substance
Abuse Research, National Health Research Institutes, Zhunan, Taiwan.
Research Interests
The research of Dr. Shie is focused on brain diseases with dementia especially in
neurodegenerative diseases including Alzheimer's disease, Parkinson’s disease, and
Niemann Pick type C disease. Dr. Shie’s research interests include the functions of
microglial innate immunity and glia-neuron interactions in pathogenesis of the brain
diseases. Revealing therapeutic targets and approaches for the diseases is the
ultimate goal of his research.
Research Activities & Accomplishment
Dr. Shie was trained at Alzheimer’s Disease Research Center at University of
Washington for researches in neurodegenerative diseases and return to home country
in the end of 2005. He has established a research record on neurodegenerative
diseases with 16 peer-viewed publication and filed 2 US patents in the recent 5
years. The major focus of Dr. Shie’s research in NHRI is to understand the
regulatory mechanisms of the glia-neuron interactions in the pathogenesis of
Alzheimer’s diseases and to gain insights into the roles of microglial activation in
the functions of neuro-inflammation.
Honors & Awards
1
ADRD Travel Fellowship, 2004, The 9th international conference on Alzheimer's
disease and related disorders. Philadelphia, PA, USA.
Poster Contest, 2004, Department of Pathology, University of Washington.
ADRC Pilot Study Award, 2002-2003, Principle investigator, Alzheimer’s Disease
Research Center at University of Washington, Seattle, WA, USA.
Research Assistantship, 1995-2000, Interdisciplinary program in Nutritional
Sciences, University of Washington School of Public Health and Community
Medicine, Seattle, WA, USA.
Publications/ including books , chapters, journal articles
Manuscripts (*corresponding):
1. Feng-Shiun Shie* and Randall L. Woltjer. Manipulating microglial activation as
a therapeutic strategy for Alzheimer's disease. Current Medicinal Chemistry.
2007;14(27):2865-2871. IF:5.2
2. Feng-Shiun Shie and Zaodung Ling. Therapeutic strategy at the crossroad of
neuroinflammation and oxidative stress in age-related neurodegenerative
diseases. Expert Opin Ther Pat. 2007;17(4):419-428. IF:1.5
3. Jinghua Jin, Feng-Shiun Shie, Jun Liu, Yan Wang, Jeanne Davis, Aimee M
Schantz, Kathleen S Montine, Thomas J Montine and Jing Zhang.
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and
associated
neurotoxicity
induced
by
aggregated
alpha-synuclein.
J
Neuroinflammation. 2007;4:2:1-10. IF:4.4
4. Randall L. Woltjer, Wendy McMahan, Dejan Milatovic, John D. Kjerulf,
Feng-Shiun Shie, Lisa Rung, Kathleen S. Montine, and Thomas J. Montine
Effects of chemical chaperones on oxidative stress and detergent-insoluble
species formation following conditional expression of amyloid precursor protein
carboxy-terminal fragment. Neurobiol Dis. 2007;25(2):427-437. IF:4.1
5. Ye Xiong, Feng-Shiun Shie, Jing Zhang, Chuan Pu Lee, and Ye-Shih Ho.
Prevention of mitochondrial dysfunction in post-trauma mouse brain by
superoxide dismutase. J Neurochem. 2005;95(3):732-744. IF:4.3
6. Feng-Shiun Shie, Kathleen S. Montine, and Thomas J. Montine. Microglial
functions in LPS-induced neuronal cytotoxicity: the role of microglial
prostaglandin E2 receptors in oxidative stress. Glia. 2005;52(1):70-77. IF:5.0
7. Feng-Shiun Shie, Kathleen S. Montine, Richard M. Breyer, and Thomas J.
Montine. Microglial EP2 as a new target to increase A-beta phagocytosis and
decrease A-beta-induced damage to neurons. Brain Pathol. 2005;15 (2):134-138.
IF:5.3
8. Feng-Shiun Shie*, Richard M. Breyer, Thomas J. Montine. Microglia lacking
2
EP2 have enhanced A-beta phagocytosis yet lack A-beta activated neurotoxicity.
Am J Pathol. 2005;166(4):1163-1172. IF:5.9
9. Jinghua Jin, Gloria E. Meredith, Leo Chen, Young Zhou, Jin Xu, Feng-Shiun
Shie, Paul Lockhart, and Jing Zhang. Quantitative proteomic analysis of
mitochondrial proteins: relevance to Lewy body formation and Parkinson’s
disease. Brain Res Mol Brain Res. 2004;24;134(1):119-138.
10. Dejan Milatovic, Snjezana Zaja-Milatovic, Kathleen S. Montine, Feng-Shiun
Shie, and Thomas J. Montine. Neuronal oxidative damage and dendritic
degeneration following activation of CD14-dependent innate immune response
in vivo. J Neuroinflammation. 2004; 21;1(1):20. IF:4.4
11. Yong Zhou, Feng-Shiun Shie, Pedro Piccardo, Thomas J. Montine, Jing Zhang.
Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate:
relevance to Parkinson’s disease. Neuroscience. 2004;128:281-291. IF:3.4
12. Ye Xiong, Feng-Shiun Shie, Jing Zhang, Chuan-Pu Lee, Ye-Shih Ho. The
protective role of cellular glutathione peroxidase against trauma-induced
mitochondrial dysfunction in mouse brain. J Stroke Cerebr Dis.
2004;13:129-137.
13. Feng-Shiun Shie, M. Diana Neely, Izumi Maezawa, Hope Wu, Sandy J. Olson,
Günther Jürgens, Kathleen S. Montine and Thomas J. Montine. Oxidized
Low-Density Lipoprotein Is Present in Astrocytes Surrounding Cerebral Infarcts
and
Stimulates
Astrocyte
Interleukin-6
Secretion.
Am
J
Pathol.
2004;164:1173-1181. IF:5.9.
14. Lee-Way Jin, Feng-Shiun Shie (co-first author), Izumi Maezawa, Inez Vincent
and Thomas Bird. Intracellular accumulation of amyloidogenic fragments of
amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is
associated with endosomal abnormalities. Am J Pathol. 2004;164:975-985
(2004;165:1447). IF:5.9
15. Feng-Shiun Shie, Renee C. LeBoeuf, Lee-Way Jin. Early Intraneuronal
beta-amyloid deposition in the hippocampus of APP transgenic mice.
NeuroReport. 2003;14:123-129. IF:2.3
16. Jochen Brich, Feng-Shiun Shie, Brian W. Howell Renhua Li, Katalin Tus,
Edward K. Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim
Herz, Jonathan A. Cooper. Genetic modulation of tau phosphorylation in the
mouse. J Neurosci. 2003;23:187-192. IF:7.5
17. Lee-Way Jin, Duy H. Hua, Feng-Shiun Shie, Izumi Maezawa, Bryce Sopher,
George M Martin. Novel tricyclic pyrone compounds prevent intracellular
APP C99-induced cell death. J Mol Neurosci. 2002;19:57-61. IF3.0
18. Feng-Shiun Shie, Lee-Way Jin, David G. Cook, James B Leverenz, Renee C
3
LeBoeuf.
Diet-Induced hypercholesterolemia enhance brain beta-amyloid
accumulation in transgenic mice. NeuroReport. 2002;13:455-459. IF:2.3
19. Zsica R. Dixon, Feng-Shiun Shie, Beverly A. Warden, Betty J. Burri, and Terry
R. Neidlinger.
The effect of a low carotenoid diet on
malondialdehyde-thiobartiburic
acid
concentrations
in
women:
a
placebo-controlled double-blind study.
Book Chapter:
J Am Coll Nutr. 1998;17:54-58. IF:2.5
Lee-Way Jin, Duy H. Hua, Feng-Shiun Shie, Izumi Maezawa, Bryce Sopher,
George M. Martin. Drug discovery and development for Alzheimer’s disease
2000: Noveltricyclic pyrone compounds prevent intracellular APP C99-induced
cell death. Edited by Howard M. Fillit and Alan W. O’Connel. Springer
Publishing company, Inc. pp89-97.
International Conference Presentations:
1. Poster: P-C Hsu and Feng-Shiun Shie. Modulation of microglial activation by
15d-PGJ2. Society for Neuroscience 2007.
2. Oral presentation: Feng-Shiun Shie, Thomas J. Montine. Microglia lacking
EP2 have enhanced A-beta phagocytosis yet lack A-beta activated neurotoxicity.
Society for Neuroscience 2004.
3. Poster: Feng-Shiun Shie, Dejan Milatovic, Snjezana Milatovic, Kathy Montine,
Thomas J. Montine. Microglial EP2 signaling is critical to neurotoxicity from
activated cerebral innate immunity. The 9th International Conference on
Alzheimer's Disease and Related Disorders 2004.
4. Poster: Lee-Way Jin, Feng-Shiun Shie, Inez Vincent, E Alvord. Cerebral
A-beta accumulation in Niemann-Pick type C disease. J Neuropath Exp Neurol
2002:61:459.
5. Poster: Feng-Shiun Shie, Inez Vincent, Lee-Way Jin. Accumulation of
beta-amyloid in neurons with Niemann-Pick type C defects. Society for
Neuroscience 2002.
6. Poster: Feng-Shiun Shie, Lee-Way Jin, James B Leverenz, Renee C LeBoeuf.
Early beta-amyloid deposition in hippocampal neurons in beta-amyloid
precursor protein 695 (APP695) transgenic mice. Neurobiology of aging.
2000(21):S225.
7.
Poster: Feng-Shiun Shie, Lee-Way Jin, James B Leverenz, Renee C LeBoeuf.
Effects of cholesterol feeding on histopathologic hallmarks of Alzheimer’s
disease in beta-myloid precursor protein (APP) Transgenic Mice. Society for
Neuroscience 1999.
Patents
4
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Title: Methods and Compositions for Treatment of Neurological Diseases and
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Disorders. US-2007-0232556-A1.
Title: Novel Neuro-protective Compounds for Neurodegenerative Diseases.
(US 61/049,052, May19, 2008)
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