Positron Emission Tomography (PET) Research Core
For those interested in imaging or image analysis, the SBM is also initiating three new cores:
 The Center for Understanding Biology using Imaging Technology (CUBIT) - aids in acquisition and
analysis of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) studies,
from assisting in grant applications to image quantification.
 PET Ex vivo Radiometabolite Lab (PERL) - Fully equipped facility for the ex vivo analysis of
radiopharmaceuticals and their metabolites in both blood and tissue samples
 Facility for Experimental Radiopharmaceutical Manufacturing (FERM) - Full cGMP manufacturing of
clinical grade radiopharmaceutical in compliance with FDA and USP guidelines. Assistance in obtaining
local (RDRC) or federal (IND) approval. Supports both preclinical and clinical PET imaging studies.
Biomedical Assay Core
The BMAC provides assay support to investigators for a variety of measurements and assays using GC-mass
spectrometers, HPLC, analox glucose analyzer, and plate readers. These include:
Hormones, metabolites, cytokines
Kinetic studies with stable isotopes
Custom assays, and RNA or DNA isolation
Collection and shipping of samples
Services available in the medical campus BSC T5-191, and at the satellite facility for outpatient studies at 33
Research Way.
Contact: Margaret.McNurland@stonybrookmedicine.edu
Clinical Research Core
Provides support, facilities and resources for the conduct of research involving human subjects to all Stony
Brook Medicine faculty through a discounted recharge mechanism.
The CRC provides the environment, support staff and nursing staff to perform research protocols.
The staff of the CRC promotes excellence in interdepartmental communication and cooperation in:
Assisting investigators in recruiting, screening and interviewing subjects
Providing education and support to new investigators, their team members and coordinators
Assisting investigators in carrying out their approved research protocols
Provide clinical care/assistance for investigator initiated research protocols
The facility is located at 33 Research Way Suite 11, Phone: 631-444-6900.
Core Director is Margaret McNurland: Margaret.McNurland@stonybrookmedicine.edu
Digestive Diseases Research and BioBank Tissue Procurement Facility
The Digestive Diseases Research Tissue Procurement Facility represents an interdepartmental effort between
Medicine, Pediatrics, Surgery, and Pathology to support systematic collection of coded patient biological
fluids (blood, stool, saliva), ex-vivo and in-vivo tissue biopsies, and detailed longitudinal clinical information
related to Digestive Disorders. The Digestive Diseases Research Tissue Procurement Facility is located in
the Division of Gastroenterology on HSC-T17. It functions under the umbrella of the Pathology BioBank
Core. Since it’s inception, samples from over 500 adult and pediatric digestive disease subjects have been
archived after stripping PHI, along with rigorously curated clinical data, and linked downstream data
(genotype, mRNA, etc…).
The BioBank Cancer Center Core banks any material obtained under informed consent. Services include:
Full archival service including vitrification/cryopreservation, RNA/DNA isolation, and cell culture
Full retrieval service including de-identified searchable online database of tissues, RNA/DNA, and cultures.
Prospective patient recruitment, and access to archived samples and clinical data
Selection of samples archived in Research Histology and Biobank
Access to samples archived with collaborating institutions: Washington University-St. Louis and SUNY
Downstate Medical Center
Access to support for IRB submission, and bioinformatics and statistical support.
Contact for Digestive Diseases: Ellen Li, M.D.-Ph.D., Director Ellen.li@stonybrook.edu
x4-2119
Contact for BioBank: Dr. Angelique Corthals, Director; Angelique.Corthals@stonybrookmedicine.edu x4-3140
Institute of Chemical Biology and Drug Discovery
The Discovery Chemistry Laboratory, located on the 7th floor of the Chemistry Building, provides parallel or
combinatorial chemical library synthesis service to the Institute Members and their collaborators. Focused
custom libraries can be created based on the expertise in library design, SAR and lead-optimization. The
Laboratory also provides custom synthesis service of natural and unnatural compounds that are not
commercially available. The laboratory is equipped with standard equipment for synthetic organic and
combinatorial chemistry.
The Analytical Instrumentation Laboratory is located on the 5th and 6th floors of the Chemistry Building.
The mission of the Laboratory is to provide expertise, equipment, and instrumentation in support of the
collaborative studies of the biomedical research of the ICB&DD members and University communities.
MicroMRI Laboratory
The MicroMRI Laboratory was located at Brookhaven National Lab,
but is decommissioned and will be moved to SBU by the end of
2015. It is equipped with a Magnex Scientific 9.4 Tesla small
animal MRI machine. Also, specific cradles and coils have been
developed by Stony Brook Investigators allowing simultaneous
ECG, EEG, and PET scanning over time or with treatments in
living rodents. Additional specific capabilities are listed below:
Metabolomics – 1HMRS: using proton magnetic resonance
spectroscopy, changes in specific metabolites visible by this
technique can be measured in vivo over time or with treatments in
specific structures.
Diffusion Tensor Imaging & Morphometry: using T2, T1 and DTI
imaging, measurements of areas (and changes in area), and water
mobility within specific regions can be made.
Cancer Imaging: using T1-weighted MRI images allows measurement
of cancer growth and metastases in the live rodent.
Contrast-Enhanced MRI: the upper panel shows the time-weighted
glymphatic transport in rat brain using Gd-DTPA as contrast agent.
PET-MRI: the lower panel shows the simultaneous acquisition of
18
FDG-PET and MRI images using a custom built RF coil for the
PET camera. This allows determination of activity in specific
regions in the live rodent.
MRI
18
FDG-PET
18
FDG-PET & MRI
Data is courtesy of SBU faculty, Drs.
Benveniste and Vaska.
NAno-RAMAN Molecular Imaging Laboratory (NARMIL).
The NAno-RAMAN Molecular Imaging Laboratory (NARMIL) hosted by the School of Marine and Atmospheric
Sciences (SoMAS) was established in January 2014 through the NSF Major Research Instrumentation
(MRI) program. The facility supports research in marine, atmospheric, environmental, biological, chemical,
geological, materials sciences, and biomedical engineering, but is open to other applications as well. The
lab provides state-of-the-art instrumentation and expertise for analyses of single cells, aerosols, natural
and engineered surfaces, minerals, biofilms, thin films, and novel synthetic materials. The lab’s vision is to
offer unique analytical solutions to chronic limitations experienced in many research areas, to enable
transformative discoveries, and to educate the next generation of scientists.
NARMIL is home to a Renishaw inVia Confocal Raman Microspectrometer and a Bruker Innova Atomic Force
Microscope. These instruments can be operated independently or coupled for co-localization and Tipenhanced Raman Scattering (TERS) and offer high performance, reliability, modular design, and userfriendly operating systems.
Research Histology Core
The Stony Brook Research Histology Core Lab (RHCL) provides clinical
and basic science investigators with access to a wide range of
histological procedures, including: gross processing of research
tissue and cellular specimens, including fixation, paraffin embedding,
sectioning and staining. Both routine hematoxylin and eosin (H&E)
and advanced immunohistochemical (IHC) staining methods are
offered. The Core staff and scientific director are available to assist in
the development of research protocols that depend on the processing
of tissue or other cellular specimens.
Stem Cell Center
• Human iPS line distribution
• Education and Training in Stem Cell propagation
• Storage and Cryopreservation
• Low Oxygen Cell Incubators
• Retrovirus
• Lentivirus
• Adenovirus
• AAV (Adeno-associated)
• Scanning/Transmission Electron Microscopy (SEM/TEM)
• Confocal Microscopy (Leica Filter-Free Spectral)
• High Content Imaging System
• Karyotyping (Call for pricing)
H. Ruttenberg, Administrator; Phone: 631-216-7424
Neural Stem Cells (magenta) cradle
multiciliated ependymal cell
descendents (glial cells, green)
Courtesy of F. McClenahan and H.
Colognato
Thermomechanical & Imaging Nanoscale Characterization
Provides multiscale characterization and imaging, with facilities for sample preparation, imaging and thermomechanical characterization in nanoscience. Instrumentation includes: TEM (JEOL JEM 1400); Upright
confocal microscope (Leica TCS SP8 X); Scanning probe microscope (Bruker Dimension ICON); AMG
EVOS fluorescence microscope; Thermal gravimetric analysis; Differential scanning calorimetry; Dynamic
mechanical analysis; Thermal conductivity meter; Spectroscopic ellipsometry (Horiba UVISEL FUV); EM
sample preparation (Leica EM UC& with cryo);
Trace Element Analytical Facility
Inductively Coupled Plasma High Resolution
Magnetic Sector Mass Spectrometer
allows an analytical capability for most
elements to sub PPB (nanogram/liter)
levels.
Rapid (30-50 samples/hour), Precise
(Analytical Precision +/- 1-2%), Stable
(long term consistency within +/-2%),
Extremely Large Usable Analytical
Concentration Range, Very Low
Instrument Blank.
Applicable with standard techniques for Nitric
Acid Digested Blood, Urine, Feces, Plant
and Animal Tissues at Environmental
(ambient) and Experimental (doped)
Concentrations.
Assistance with Sample Dissolution/ Preparation Protocol is Available.
david.hirschberg@stonybrook.edu; 631-632-8744
Trace Organic Chemical Mass Spectrometry Laboratory
Offering project-specific HPLC-MS and GC-MS analysis of sediment, soil, aqueous, and tissue samples.
The Trace Organic Chemical Mass Spectrometry Laboratory was established at the Marines Sciences
Research Center at Stony Brook University under the direction of Prof. Bruce. J. Brownawell in 2001.
The laboratory now offers mass spectrometry and related services to outside investigators on a fee for service
basis providing research level and project-specific sample extractions, purifications and GC, HPLC-MS and
GC-MS and HPLC analysis of sediment, soil, aqueous, and tissue samples.
Services available include analysis of neutral alkylphenol ethoxylate metabolites, such as nonylphenol; steroid
estrogen hormones; modern use pesticides such as organophosphates, pyrethroids, and methoprene; high
volume pharmaceuticals; polycyclic aromatic hydrocarbons; polychlorinated biphenyls; and fluorescent
whitening agents.